4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
2Q94A 2EA4A 5D6EA 2Q93A 1YW9A 4U6ZA 5CDVA 4Z7MA 1YW8A 3BIQA 4U1BA 2GG7A 2GGCA 2GU6A 5JFRA 2BWWA 2GU4A 2GG8A 1WLRA 4IF7A 1YW7A 1BOAA 4IECA 2ZSGA 1XGMA 1MATA 1C21A 4B28A 1YVMA 2BHDA 4IDYA 4IKUA 4FLJA 1C27A 2IW2A 1QXYA 1Y1NA 4FO8A 3IU9A 1QZYA 3BIPA 1KQ0A 1R5HA 2BWSA 1BN5A 5CDLA 2B3KA 3PKCA 1B6AA 4U6CA 4U71A 3TB5A 2EVCA 1WY2A 4QR8A 3FMRA 2BN7A 5CLSA 1B59A 5FCHA 4EGEA 2GGBA 1WL6A 2BWTA 1XNZA 3PKAA 5JHUA 1WL9A 2NQ6A 4S00A 4S2TP 1C24A 1WN1A 5CDEA 2MATA 2BHAA 4IU6A 1YJ3A 1KQ9A 1W7VA 2OAZA 3FMQA 1XGNA 3PKDA 5D6FA 2Q8KA 4PNCA 4ZWOA 2GU7A 5E5BA 4A6VA 1XGOA 2GG9A 4FUKA 2G6PA 2BH3A 4IKSA 2GA2A 2EA2A 1WKMA 2BWVA 3Q6DA 4S2RP 4U75A 4JUQA 4PV4A 4U6WA 2HOWA 3PKEA 3IU7A 1QXWA 3IG4A 5JI6A 2EVOA 2BB7A 2B3LA 2P98A 3TAVA 4IPAA 2BWYA 4FO7A 2GZ5A 4U73A 2DFIA 1KP0A 4IKRA 4U69A 2P99A 1R5GA 4FLIA 4FLKA 4S01A 5CE6A 3BITA 3CTZA 1N51A 2V3YA 4MATA 2Q96A 1XGSA 2EVMA 4RZZA 1W2MA 1PV9A 4OOKA 2BWXA 3RVAA 2GG5A 2ADUA 1CHMA 1O0XA 1C23A 3L24A 2BWUA 3S6BA 1C22A 1A16A 2GG0A 5CNXA 3IU8A 2GG3A 4U6EA 2Q92A 4KM3A 3PKBA 5FCFA 3FM3A 3RORA 4RZYA 4U70A 1QXZA 3MATA 3MR1A 4IKTA 4U6JA 1M35A 4FKCA 4ZNGA 5CIKA 2OKNA 1R58A 3L7GA 2BHCA 4ZWPA 2V6CA 2GG2A 4U76A 2GU5A 2NQ7A 2V3ZA 4ZWUA 1WBQA 3CB6A 3CB5A 2V3XA 4A6WA 2BHBA 2GTXA 2B3HA 3D27A 4RGZ1 4R60A 4HXXA 1JAWA 2P9AA 3MX6A 2Q95A 4FLLA
chains in the Genus database with same CATH superfamily
2Q94A 2EA4A 5D6EA 2Q93A 1YW9A 4U6ZA 5CDVA 4Z7MA 1YW8A 3BIQA 4U1BA 2GG7A 2GGCA 2GU6A 5JFRA 2BWWA 2GU4A 2GG8A 1WLRA 4IF7A 1YW7A 1BOAA 4IECA 2ZSGA 1XGMA 1MATA 1C21A 4B28A 1YVMA 2BHDA 4IDYA 4IKUA 4FLJA 1C27A 2IW2A 1QXYA 1Y1NA 4FO8A 3IU9A 1QZYA 3BIPA 1KQ0A 1R5HA 2BWSA 1BN5A 5CDLA 2B3KA 3PKCA 1B6AA 4U6CA 4U71A 3TB5A 2EVCA 1WY2A 4QR8A 3FMRA 2BN7A 5CLSA 1B59A 5FCHA 4EGEA 2GGBA 1WL6A 2BWTA 1XNZA 3PKAA 5JHUA 1WL9A 2NQ6A 4S00A 4S2TP 1C24A 1WN1A 5CDEA 2MATA 2BHAA 4IU6A 1YJ3A 1KQ9A 1W7VA 2OAZA 3FMQA 1XGNA 3PKDA 5D6FA 2Q8KA 4PNCA 4ZWOA 2GU7A 5E5BA 4A6VA 1XGOA 2GG9A 4FUKA 2G6PA 2BH3A 4IKSA 2GA2A 2EA2A 1WKMA 2BWVA 3Q6DA 4S2RP 4U75A 4JUQA 4PV4A 4U6WA 2HOWA 3PKEA 3IU7A 1QXWA 3IG4A 5JI6A 2EVOA 2BB7A 2B3LA 2P98A 3TAVA 4IPAA 2BWYA 4FO7A 2GZ5A 4U73A 2DFIA 1KP0A 4IKRA 4U69A 2P99A 1R5GA 4FLIA 4FLKA 4S01A 5CE6A 3BITA 3CTZA 1N51A 2V3YA 4MATA 2Q96A 1XGSA 2EVMA 4RZZA 1W2MA 1PV9A 4OOKA 2BWXA 3RVAA 2GG5A 2ADUA 1CHMA 1O0XA 1C23A 3L24A 2BWUA 3S6BA 1C22A 1A16A 2GG0A 5CNXA 3IU8A 2GG3A 4U6EA 2Q92A 4KM3A 3PKBA 5FCFA 3FM3A 3RORA 4RZYA 4U70A 1QXZA 3MATA 3MR1A 4IKTA 4U6JA 1M35A 4FKCA 4ZNGA 5CIKA 2OKNA 1R58A 3L7GA 2BHCA 4ZWPA 2V6CA 2GG2A 4U76A 2GU5A 2NQ7A 2V3ZA 4ZWUA 1WBQA 3CB6A 3CB5A 2V3XA 4A6WA 2BHBA 2GTXA 2B3HA 3D27A 4RGZ1 4R60A 4HXXA 1JAWA 2P9AA 3MX6A 2Q95A 4FLLA
chains in the Genus database with same CATH topology
2Q94A 2EA4A 5D6EA 2Q93A 1YW9A 4U6ZA 5CDVA 4Z7MA 1YW8A 3BIQA 4U1BA 2GG7A 2GGCA 2GU6A 5JFRA 2BWWA 2GU4A 2GG8A 1WLRA 4IF7A 1YW7A 1BOAA 4IECA 2ZSGA 1XGMA 1MATA 1C21A 4B28A 1YVMA 2BHDA 4IDYA 4IKUA 4FLJA 1C27A 2IW2A 1QXYA 1Y1NA 4FO8A 3IU9A 1QZYA 3BIPA 1KQ0A 1R5HA 2BWSA 1BN5A 5CDLA 2B3KA 3PKCA 1B6AA 4U6CA 4U71A 3TB5A 2EVCA 1WY2A 4QR8A 3FMRA 2BN7A 5CLSA 1B59A 5FCHA 4EGEA 2GGBA 1WL6A 2BWTA 1XNZA 3PKAA 5JHUA 1WL9A 2NQ6A 4S00A 4S2TP 1C24A 1WN1A 5CDEA 2MATA 2BHAA 4IU6A 1YJ3A 1KQ9A 1W7VA 2OAZA 3FMQA 1XGNA 3PKDA 5D6FA 2Q8KA 4PNCA 4ZWOA 2GU7A 5E5BA 4A6VA 1XGOA 2GG9A 4FUKA 2G6PA 2BH3A 4IKSA 2GA2A 2EA2A 1WKMA 2BWVA 3Q6DA 4S2RP 4U75A 4JUQA 4PV4A 4U6WA 2HOWA 3PKEA 3IU7A 1QXWA 3IG4A 5JI6A 2EVOA 2BB7A 2B3LA 2P98A 3TAVA 4IPAA 2BWYA 4FO7A 2GZ5A 4U73A 2DFIA 1KP0A 4IKRA 4U69A 2P99A 1R5GA 4FLIA 4FLKA 4S01A 5CE6A 3BITA 3CTZA 1N51A 2V3YA 4MATA 2Q96A 1XGSA 2EVMA 4RZZA 1W2MA 1PV9A 4OOKA 2BWXA 3RVAA 2GG5A 2ADUA 1CHMA 1O0XA 1C23A 3L24A 2BWUA 3S6BA 1C22A 1A16A 2GG0A 5CNXA 3IU8A 2GG3A 4U6EA 2Q92A 4KM3A 3PKBA 5FCFA 3FM3A 3RORA 4RZYA 4U70A 1QXZA 3MATA 3MR1A 4IKTA 4U6JA 1M35A 4FKCA 4ZNGA 5CIKA 2OKNA 1R58A 3L7GA 2BHCA 4ZWPA 2V6CA 2GG2A 4U76A 2GU5A 2NQ7A 2V3ZA 4ZWUA 1WBQA 3CB6A 3CB5A 2V3XA 4A6WA 2BHBA 2GTXA 2B3HA 3D27A 4RGZ1 4R60A 4HXXA 1JAWA 2P9AA 3MX6A 2Q95A 4FLLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q94 A;  2EA4 A;  5D6E A;  2Q93 A;  1YW9 A;  4U6Z A;  5CDV A;  4Z7M A;  1YW8 A;  3BIQ A;  4U1B A;  2GG7 A;  2GGC A;  2GU6 A;  5JFR A;  2BWW A;  2GU4 A;  2GG8 A;  1WLR A;  4IF7 A;  1YW7 A;  1BOA A;  4IEC A;  2ZSG A;  1XGM A;  1MAT A;  1C21 A;  4B28 A;  1YVM A;  2BHD A;  4IDY A;  4IKU A;  4FLJ A;  1C27 A;  2IW2 A;  1QXY A;  1Y1N A;  4FO8 A;  3IU9 A;  1QZY A;  3BIP A;  1KQ0 A;  1R5H A;  2BWS A;  1BN5 A;  5CDL A;  2B3K A;  3PKC A;  1B6A A;  4U6C A;  4U71 A;  3TB5 A;  2EVC A;  1WY2 A;  4QR8 A;  3FMR A;  2BN7 A;  5CLS A;  1B59 A;  5FCH A;  4EGE A;  2GGB A;  1WL6 A;  2BWT A;  1XNZ A;  3PKA A;  5JHU A;  1WL9 A;  2NQ6 A;  4S00 A;  4S2T P;  1C24 A;  1WN1 A;  5CDE A;  2MAT A;  2BHA A;  4IU6 A;  1YJ3 A;  1KQ9 A;  1W7V A;  2OAZ A;  3FMQ A;  1XGN A;  3PKD A;  5D6F A;  2Q8K A;  4PNC A;  4ZWO A;  2GU7 A;  5E5B A;  4A6V A;  1XGO A;  2GG9 A;  4FUK A;  2G6P A;  2BH3 A;  4IKS A;  2GA2 A;  2EA2 A;  1WKM A;  2BWV A;  3Q6D A;  4S2R P;  4U75 A;  4JUQ A;  4PV4 A;  4U6W A;  2HOW A;  3PKE A;  3IU7 A;  1QXW A;  3IG4 A;  5JI6 A;  2EVO A;  2BB7 A;  2B3L A;  2P98 A;  3TAV A;  4IPA A;  2BWY A;  4FO7 A;  2GZ5 A;  4U73 A;  2DFI A;  1KP0 A;  4IKR A;  4U69 A;  2P99 A;  1R5G A;  4FLI A;  4FLK A;  4S01 A;  5CE6 A;  3BIT A;  3CTZ A;  1N51 A;  2V3Y A;  4MAT A;  2Q96 A;  1XGS A;  2EVM A;  4RZZ A;  1W2M A;  1PV9 A;  4OOK A;  2BWX A;  3RVA A;  2GG5 A;  2ADU A;  1CHM A;  1O0X A;  1C23 A;  3L24 A;  2BWU A;  3S6B A;  1C22 A;  1A16 A;  2GG0 A;  5CNX A;  3IU8 A;  2GG3 A;  4U6E A;  2Q92 A;  4KM3 A;  3PKB A;  5FCF A;  3FM3 A;  3ROR A;  4RZY A;  4U70 A;  1QXZ A;  3MAT A;  3MR1 A;  4IKT A;  4U6J A;  1M35 A;  4FKC A;  4ZNG A;  5CIK A;  2OKN A;  1R58 A;  3L7G A;  2BHC A;  4ZWP A;  2V6C A;  2GG2 A;  4U76 A;  2GU5 A;  2NQ7 A;  2V3Z A;  4ZWU A;  1WBQ A;  3CB6 A;  3CB5 A;  2V3X A;  4A6W A;  2BHB A;  2GTX A;  2B3H A;  3D27 A;  4RGZ 1;  4R60 A;  4HXX A;  1JAW A;  2P9A A;  3MX6 A;  2Q95 A;  4FLL A; 
#chains in the Genus database with same CATH topology
 2Q94 A;  2EA4 A;  5D6E A;  2Q93 A;  1YW9 A;  4U6Z A;  5CDV A;  4Z7M A;  1YW8 A;  3BIQ A;  4U1B A;  2GG7 A;  2GGC A;  2GU6 A;  5JFR A;  2BWW A;  2GU4 A;  2GG8 A;  1WLR A;  4IF7 A;  1YW7 A;  1BOA A;  4IEC A;  2ZSG A;  1XGM A;  1MAT A;  1C21 A;  4B28 A;  1YVM A;  2BHD A;  4IDY A;  4IKU A;  4FLJ A;  1C27 A;  2IW2 A;  1QXY A;  1Y1N A;  4FO8 A;  3IU9 A;  1QZY A;  3BIP A;  1KQ0 A;  1R5H A;  2BWS A;  1BN5 A;  5CDL A;  2B3K A;  3PKC A;  1B6A A;  4U6C A;  4U71 A;  3TB5 A;  2EVC A;  1WY2 A;  4QR8 A;  3FMR A;  2BN7 A;  5CLS A;  1B59 A;  5FCH A;  4EGE A;  2GGB A;  1WL6 A;  2BWT A;  1XNZ A;  3PKA A;  5JHU A;  1WL9 A;  2NQ6 A;  4S00 A;  4S2T P;  1C24 A;  1WN1 A;  5CDE A;  2MAT A;  2BHA A;  4IU6 A;  1YJ3 A;  1KQ9 A;  1W7V A;  2OAZ A;  3FMQ A;  1XGN A;  3PKD A;  5D6F A;  2Q8K A;  4PNC A;  4ZWO A;  2GU7 A;  5E5B A;  4A6V A;  1XGO A;  2GG9 A;  4FUK A;  2G6P A;  2BH3 A;  4IKS A;  2GA2 A;  2EA2 A;  1WKM A;  2BWV A;  3Q6D A;  4S2R P;  4U75 A;  4JUQ A;  4PV4 A;  4U6W A;  2HOW A;  3PKE A;  3IU7 A;  1QXW A;  3IG4 A;  5JI6 A;  2EVO A;  2BB7 A;  2B3L A;  2P98 A;  3TAV A;  4IPA A;  2BWY A;  4FO7 A;  2GZ5 A;  4U73 A;  2DFI A;  1KP0 A;  4IKR A;  4U69 A;  2P99 A;  1R5G A;  4FLI A;  4FLK A;  4S01 A;  5CE6 A;  3BIT A;  3CTZ A;  1N51 A;  2V3Y A;  4MAT A;  2Q96 A;  1XGS A;  2EVM A;  4RZZ A;  1W2M A;  1PV9 A;  4OOK A;  2BWX A;  3RVA A;  2GG5 A;  2ADU A;  1CHM A;  1O0X A;  1C23 A;  3L24 A;  2BWU A;  3S6B A;  1C22 A;  1A16 A;  2GG0 A;  5CNX A;  3IU8 A;  2GG3 A;  4U6E A;  2Q92 A;  4KM3 A;  3PKB A;  5FCF A;  3FM3 A;  3ROR A;  4RZY A;  4U70 A;  1QXZ A;  3MAT A;  3MR1 A;  4IKT A;  4U6J A;  1M35 A;  4FKC A;  4ZNG A;  5CIK A;  2OKN A;  1R58 A;  3L7G A;  2BHC A;  4ZWP A;  2V6C A;  2GG2 A;  4U76 A;  2GU5 A;  2NQ7 A;  2V3Z A;  4ZWU A;  1WBQ A;  3CB6 A;  3CB5 A;  2V3X A;  4A6W A;  2BHB A;  2GTX A;  2B3H A;  3D27 A;  4RGZ 1;  4R60 A;  4HXX A;  1JAW A;  2P9A A;  3MX6 A;  2Q95 A;  4FLL A; 
#chains in the Genus database with same CATH homology
 2Q94 A;  2EA4 A;  5D6E A;  2Q93 A;  1YW9 A;  4U6Z A;  5CDV A;  4Z7M A;  1YW8 A;  3BIQ A;  4U1B A;  2GG7 A;  2GGC A;  2GU6 A;  5JFR A;  2BWW A;  2GU4 A;  2GG8 A;  1WLR A;  4IF7 A;  1YW7 A;  1BOA A;  4IEC A;  2ZSG A;  1XGM A;  1MAT A;  1C21 A;  4B28 A;  1YVM A;  2BHD A;  4IDY A;  4IKU A;  4FLJ A;  1C27 A;  2IW2 A;  1QXY A;  1Y1N A;  4FO8 A;  3IU9 A;  1QZY A;  3BIP A;  1KQ0 A;  1R5H A;  2BWS A;  1BN5 A;  5CDL A;  2B3K A;  3PKC A;  1B6A A;  4U6C A;  4U71 A;  3TB5 A;  2EVC A;  1WY2 A;  4QR8 A;  3FMR A;  2BN7 A;  5CLS A;  1B59 A;  5FCH A;  4EGE A;  2GGB A;  1WL6 A;  2BWT A;  1XNZ A;  3PKA A;  5JHU A;  1WL9 A;  2NQ6 A;  4S00 A;  4S2T P;  1C24 A;  1WN1 A;  5CDE A;  2MAT A;  2BHA A;  4IU6 A;  1YJ3 A;  1KQ9 A;  1W7V A;  2OAZ A;  3FMQ A;  1XGN A;  3PKD A;  5D6F A;  2Q8K A;  4PNC A;  4ZWO A;  2GU7 A;  5E5B A;  4A6V A;  1XGO A;  2GG9 A;  4FUK A;  2G6P A;  2BH3 A;  4IKS A;  2GA2 A;  2EA2 A;  1WKM A;  2BWV A;  3Q6D A;  4S2R P;  4U75 A;  4JUQ A;  4PV4 A;  4U6W A;  2HOW A;  3PKE A;  3IU7 A;  1QXW A;  3IG4 A;  5JI6 A;  2EVO A;  2BB7 A;  2B3L A;  2P98 A;  3TAV A;  4IPA A;  2BWY A;  4FO7 A;  2GZ5 A;  4U73 A;  2DFI A;  1KP0 A;  4IKR A;  4U69 A;  2P99 A;  1R5G A;  4FLI A;  4FLK A;  4S01 A;  5CE6 A;  3BIT A;  3CTZ A;  1N51 A;  2V3Y A;  4MAT A;  2Q96 A;  1XGS A;  2EVM A;  4RZZ A;  1W2M A;  1PV9 A;  4OOK A;  2BWX A;  3RVA A;  2GG5 A;  2ADU A;  1CHM A;  1O0X A;  1C23 A;  3L24 A;  2BWU A;  3S6B A;  1C22 A;  1A16 A;  2GG0 A;  5CNX A;  3IU8 A;  2GG3 A;  4U6E A;  2Q92 A;  4KM3 A;  3PKB A;  5FCF A;  3FM3 A;  3ROR A;  4RZY A;  4U70 A;  1QXZ A;  3MAT A;  3MR1 A;  4IKT A;  4U6J A;  1M35 A;  4FKC A;  4ZNG A;  5CIK A;  2OKN A;  1R58 A;  3L7G A;  2BHC A;  4ZWP A;  2V6C A;  2GG2 A;  4U76 A;  2GU5 A;  2NQ7 A;  2V3Z A;  4ZWU A;  1WBQ A;  3CB6 A;  3CB5 A;  2V3X A;  4A6W A;  2BHB A;  2GTX A;  2B3H A;  3D27 A;  4RGZ 1;  4R60 A;  4HXX A;  1JAW A;  2P9A A;  3MX6 A;  2Q95 A;  4FLL A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...