4U6E | Genus

Total Genus 101

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	101
sequence length	304
structure length	304
Chain Sequence	YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase/hydrolase inhibitor
source organism	Homo sapiens
publication title	Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases pubmed doi rcsb
molecule keywords	Methionine aminopeptidase 1
total genus	101
structure length	304
sequence length	304
ec nomenclature	ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date	2014-07-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00557	Peptidase_M24	Metallopeptidase family M24

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.230.10	Alpha Beta	Alpha-Beta Complex	Creatine Amidinohydrolase	Creatinase/methionine aminopeptidase superfamily	4u6eA00

1R5HA 3PKBA 2BWSA 4ZNGA 4U6EA 2BWTA 2P98A 4ZWPA 4FLLA 4RZZA 4S2RP 2P9AA 2GU5A 2GU4A 4IKRA 1R5GA 3IU9A 4IU6A 4MATA 4FLJA 4KM3A 1B59A 5FCHA 4FLIA 2OAZA 3BIPA 1C21A 3BITA 4S01A 5D6FA 2GG0A 3RORA 2BWXA 1QXYA 1KQ9A 3PKCA 5CDEA 1YJ3A 2V3XA 1QXWA 1YW9A 3FMQA 1WLRA 3Q6DA 1XGOA 1B6AA 2BWVA 4RZYA 2GG8A 3CB5A 2BWWA 4IF7A 1JAWA 3BIQA 3CB6A 1YW7A 4U70A 2BHDA 4FLKA 2GTXA 2Q96A 3IU8A 4U75A 1XNZA 3FMRA 4HXXA 1A16A 4U73A 4IKUA 1XGNA 3CTZA 3S6BA 4EGEA 4U6WA 1C24A 4Z7MA 1QZYA 4JUQA 3L24A 4U6ZA 3IU7A 5JHUA 4PV4A 1YW8A 2B3HA 4PNCA 1PV9A 4U69A 1W2MA 2BWUA 4FUKA 2GZ5A 4OOKA 2EVCA 4S2TP 2BH3A 1WKMA 1CHMA 2BB7A 1C23A 1C27A 2B3LA 2V3YA 3D27A 4IECA 3TB5A 5CLSA 2ZSGA 2V3ZA 5CDVA 2BN7A 4IKTA 4IDYA 5FCFA 2V6CA 2NQ7A 1BOAA 1KQ0A 2GU6A 4ZWUA 4U6JA 2Q95A 2Q94A 2IW2A 4A6WA 4QR8A 1XGSA 2BWYA 2EVOA 3IG4A 4FKCA 5JFRA 2NQ6A 5CE6A 1WL6A 3PKAA 5E5BA 2BHCA 1MATA 3TAVA 2GG2A 3L7GA 4U6CA 2Q93A 3PKDA 2EA4A 4U1BA 4IPAA 1WY2A 4ZWOA 1R58A 2GG7A 3RVAA 4FO7A 2EA2A 2BHAA 2P99A 3MX6A 2DFIA 1BN5A 1WN1A 2GG3A 4U71A 4RGZ1 4U76A 2G6PA 2BHBA 4A6VA 1WL9A 5JI6A 1W7VA 2GGCA 2GGBA 2HOWA 2GG5A 5D6EA 3MATA 1M35A 2GG9A 4R60A 2B3KA 3PKEA 5CNXA 1Y1NA 1YVMA 2Q8KA 1QXZA 2OKNA 2GU7A 3MR1A 1KP0A 1C22A 1O0XA 1WBQA 4B28A 5CDLA 1N51A 2EVMA 2Q92A 4IKSA 5CIKA 4S00A 2MATA 3FM3A 1XGMA 2ADUA 2GA2A 4FO8A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1R5H A;  3PKB A;  2BWS A;  4ZNG A;  4U6E A;  2BWT A;  2P98 A;  4ZWP A;  4FLL A;  4RZZ A;  4S2R P;  2P9A A;  2GU5 A;  2GU4 A;  4IKR A;  1R5G A;  3IU9 A;  4IU6 A;  4MAT A;  4FLJ A;  4KM3 A;  1B59 A;  5FCH A;  4FLI A;  2OAZ A;  3BIP A;  1C21 A;  3BIT A;  4S01 A;  5D6F A;  2GG0 A;  3ROR A;  2BWX A;  1QXY A;  1KQ9 A;  3PKC A;  5CDE A;  1YJ3 A;  2V3X A;  1QXW A;  1YW9 A;  3FMQ A;  1WLR A;  3Q6D A;  1XGO A;  1B6A A;  2BWV A;  4RZY A;  2GG8 A;  3CB5 A;  2BWW A;  4IF7 A;  1JAW A;  3BIQ A;  3CB6 A;  1YW7 A;  4U70 A;  2BHD A;  4FLK A;  2GTX A;  2Q96 A;  3IU8 A;  4U75 A;  1XNZ A;  3FMR A;  4HXX A;  1A16 A;  4U73 A;  4IKU A;  1XGN A;  3CTZ A;  3S6B A;  4EGE A;  4U6W A;  1C24 A;  4Z7M A;  1QZY A;  4JUQ A;  3L24 A;  4U6Z A;  3IU7 A;  5JHU A;  4PV4 A;  1YW8 A;  2B3H A;  4PNC A;  1PV9 A;  4U69 A;  1W2M A;  2BWU A;  4FUK A;  2GZ5 A;  4OOK A;  2EVC A;  4S2T P;  2BH3 A;  1WKM A;  1CHM A;  2BB7 A;  1C23 A;  1C27 A;  2B3L A;  2V3Y A;  3D27 A;  4IEC A;  3TB5 A;  5CLS A;  2ZSG A;  2V3Z A;  5CDV A;  2BN7 A;  4IKT A;  4IDY A;  5FCF A;  2V6C A;  2NQ7 A;  1BOA A;  1KQ0 A;  2GU6 A;  4ZWU A;  4U6J A;  2Q95 A;  2Q94 A;  2IW2 A;  4A6W A;  4QR8 A;  1XGS A;  2BWY A;  2EVO A;  3IG4 A;  4FKC A;  5JFR A;  2NQ6 A;  5CE6 A;  1WL6 A;  3PKA A;  5E5B A;  2BHC A;  1MAT A;  3TAV A;  2GG2 A;  3L7G A;  4U6C A;  2Q93 A;  3PKD A;  2EA4 A;  4U1B A;  4IPA A;  1WY2 A;  4ZWO A;  1R58 A;  2GG7 A;  3RVA A;  4FO7 A;  2EA2 A;  2BHA A;  2P99 A;  3MX6 A;  2DFI A;  1BN5 A;  1WN1 A;  2GG3 A;  4U71 A;  4RGZ 1;  4U76 A;  2G6P A;  2BHB A;  4A6V A;  1WL9 A;  5JI6 A;  1W7V A;  2GGC A;  2GGB A;  2HOW A;  2GG5 A;  5D6E A;  3MAT A;  1M35 A;  2GG9 A;  4R60 A;  2B3K A;  3PKE A;  5CNX A;  1Y1N A;  1YVM A;  2Q8K A;  1QXZ A;  2OKN A;  2GU7 A;  3MR1 A;  1KP0 A;  1C22 A;  1O0X A;  1WBQ A;  4B28 A;  5CDL A;  1N51 A;  2EVM A;  2Q92 A;  4IKS A;  5CIK A;  4S00 A;  2MAT A;  3FM3 A;  1XGM A;  2ADU A;  2GA2 A;  4FO8 A; 
#chains in the Genus database with same CATH topology
 1R5H A;  3PKB A;  2BWS A;  4ZNG A;  4U6E A;  2BWT A;  2P98 A;  4ZWP A;  4FLL A;  4RZZ A;  4S2R P;  2P9A A;  2GU5 A;  2GU4 A;  4IKR A;  1R5G A;  3IU9 A;  4IU6 A;  4MAT A;  4FLJ A;  4KM3 A;  1B59 A;  5FCH A;  4FLI A;  2OAZ A;  3BIP A;  1C21 A;  3BIT A;  4S01 A;  5D6F A;  2GG0 A;  3ROR A;  2BWX A;  1QXY A;  1KQ9 A;  3PKC A;  5CDE A;  1YJ3 A;  2V3X A;  1QXW A;  1YW9 A;  3FMQ A;  1WLR A;  3Q6D A;  1XGO A;  1B6A A;  2BWV A;  4RZY A;  2GG8 A;  3CB5 A;  2BWW A;  4IF7 A;  1JAW A;  3BIQ A;  3CB6 A;  1YW7 A;  4U70 A;  2BHD A;  4FLK A;  2GTX A;  2Q96 A;  3IU8 A;  4U75 A;  1XNZ A;  3FMR A;  4HXX A;  1A16 A;  4U73 A;  4IKU A;  1XGN A;  3CTZ A;  3S6B A;  4EGE A;  4U6W A;  1C24 A;  4Z7M A;  1QZY A;  4JUQ A;  3L24 A;  4U6Z A;  3IU7 A;  5JHU A;  4PV4 A;  1YW8 A;  2B3H A;  4PNC A;  1PV9 A;  4U69 A;  1W2M A;  2BWU A;  4FUK A;  2GZ5 A;  4OOK A;  2EVC A;  4S2T P;  2BH3 A;  1WKM A;  1CHM A;  2BB7 A;  1C23 A;  1C27 A;  2B3L A;  2V3Y A;  3D27 A;  4IEC A;  3TB5 A;  5CLS A;  2ZSG A;  2V3Z A;  5CDV A;  2BN7 A;  4IKT A;  4IDY A;  5FCF A;  2V6C A;  2NQ7 A;  1BOA A;  1KQ0 A;  2GU6 A;  4ZWU A;  4U6J A;  2Q95 A;  2Q94 A;  2IW2 A;  4A6W A;  4QR8 A;  1XGS A;  2BWY A;  2EVO A;  3IG4 A;  4FKC A;  5JFR A;  2NQ6 A;  5CE6 A;  1WL6 A;  3PKA A;  5E5B A;  2BHC A;  1MAT A;  3TAV A;  2GG2 A;  3L7G A;  4U6C A;  2Q93 A;  3PKD A;  2EA4 A;  4U1B A;  4IPA A;  1WY2 A;  4ZWO A;  1R58 A;  2GG7 A;  3RVA A;  4FO7 A;  2EA2 A;  2BHA A;  2P99 A;  3MX6 A;  2DFI A;  1BN5 A;  1WN1 A;  2GG3 A;  4U71 A;  4RGZ 1;  4U76 A;  2G6P A;  2BHB A;  4A6V A;  1WL9 A;  5JI6 A;  1W7V A;  2GGC A;  2GGB A;  2HOW A;  2GG5 A;  5D6E A;  3MAT A;  1M35 A;  2GG9 A;  4R60 A;  2B3K A;  3PKE A;  5CNX A;  1Y1N A;  1YVM A;  2Q8K A;  1QXZ A;  2OKN A;  2GU7 A;  3MR1 A;  1KP0 A;  1C22 A;  1O0X A;  1WBQ A;  4B28 A;  5CDL A;  1N51 A;  2EVM A;  2Q92 A;  4IKS A;  5CIK A;  4S00 A;  2MAT A;  3FM3 A;  1XGM A;  2ADU A;  2GA2 A;  4FO8 A; 
#chains in the Genus database with same CATH homology
 1R5H A;  3PKB A;  2BWS A;  4ZNG A;  4U6E A;  2BWT A;  2P98 A;  4ZWP A;  4FLL A;  4RZZ A;  4S2R P;  2P9A A;  2GU5 A;  2GU4 A;  4IKR A;  1R5G A;  3IU9 A;  4IU6 A;  4MAT A;  4FLJ A;  4KM3 A;  1B59 A;  5FCH A;  4FLI A;  2OAZ A;  3BIP A;  1C21 A;  3BIT A;  4S01 A;  5D6F A;  2GG0 A;  3ROR A;  2BWX A;  1QXY A;  1KQ9 A;  3PKC A;  5CDE A;  1YJ3 A;  2V3X A;  1QXW A;  1YW9 A;  3FMQ A;  1WLR A;  3Q6D A;  1XGO A;  1B6A A;  2BWV A;  4RZY A;  2GG8 A;  3CB5 A;  2BWW A;  4IF7 A;  1JAW A;  3BIQ A;  3CB6 A;  1YW7 A;  4U70 A;  2BHD A;  4FLK A;  2GTX A;  2Q96 A;  3IU8 A;  4U75 A;  1XNZ A;  3FMR A;  4HXX A;  1A16 A;  4U73 A;  4IKU A;  1XGN A;  3CTZ A;  3S6B A;  4EGE A;  4U6W A;  1C24 A;  4Z7M A;  1QZY A;  4JUQ A;  3L24 A;  4U6Z A;  3IU7 A;  5JHU A;  4PV4 A;  1YW8 A;  2B3H A;  4PNC A;  1PV9 A;  4U69 A;  1W2M A;  2BWU A;  4FUK A;  2GZ5 A;  4OOK A;  2EVC A;  4S2T P;  2BH3 A;  1WKM A;  1CHM A;  2BB7 A;  1C23 A;  1C27 A;  2B3L A;  2V3Y A;  3D27 A;  4IEC A;  3TB5 A;  5CLS A;  2ZSG A;  2V3Z A;  5CDV A;  2BN7 A;  4IKT A;  4IDY A;  5FCF A;  2V6C A;  2NQ7 A;  1BOA A;  1KQ0 A;  2GU6 A;  4ZWU A;  4U6J A;  2Q95 A;  2Q94 A;  2IW2 A;  4A6W A;  4QR8 A;  1XGS A;  2BWY A;  2EVO A;  3IG4 A;  4FKC A;  5JFR A;  2NQ6 A;  5CE6 A;  1WL6 A;  3PKA A;  5E5B A;  2BHC A;  1MAT A;  3TAV A;  2GG2 A;  3L7G A;  4U6C A;  2Q93 A;  3PKD A;  2EA4 A;  4U1B A;  4IPA A;  1WY2 A;  4ZWO A;  1R58 A;  2GG7 A;  3RVA A;  4FO7 A;  2EA2 A;  2BHA A;  2P99 A;  3MX6 A;  2DFI A;  1BN5 A;  1WN1 A;  2GG3 A;  4U71 A;  4RGZ 1;  4U76 A;  2G6P A;  2BHB A;  4A6V A;  1WL9 A;  5JI6 A;  1W7V A;  2GGC A;  2GGB A;  2HOW A;  2GG5 A;  5D6E A;  3MAT A;  1M35 A;  2GG9 A;  4R60 A;  2B3K A;  3PKE A;  5CNX A;  1Y1N A;  1YVM A;  2Q8K A;  1QXZ A;  2OKN A;  2GU7 A;  3MR1 A;  1KP0 A;  1C22 A;  1O0X A;  1WBQ A;  4B28 A;  5CDL A;  1N51 A;  2EVM A;  2Q92 A;  4IKS A;  5CIK A;  4S00 A;  2MAT A;  3FM3 A;  1XGM A;  2ADU A;  2GA2 A;  4FO8 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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4U6EA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations