4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
4IKSA 4IU6A 3TB5A 4ZNGA 4U73A 2BWYA 3MR1A 4IF7A 2V3YA 2EVOA 1W2MA 1CHMA 1C23A 3FM3A 4PNCA 2GA2A 2B3LA 1C27A 5E5BA 4IPAA 4IKRA 3BITA 3PKBA 1B59A 4FUKA 2DFIA 4JUQA 4A6VA 4S2TP 3FMRA 2BHDA 5D6FA 1QXWA 4IDYA 5CDLA 4U6EA 5CE6A 2BWSA 3L7GA 3D27A 2GZ5A 2GG0A 4RZZA 4RZYA 1MATA 1A16A 5CNXA 4ZWPA 1YW9A 2BWTA 4U6JA 2GTXA 1R58A 2GU4A 1R5GA 3CB5A 2BN7A 3CTZA 3PKCA 2ADUA 3RORA 5FCHA 2V3ZA 4FO7A 4MATA 1WL6A 4PV4A 3CB6A 2P9AA 4A6WA 3BIPA 4ZWUA 4FLJA 4IKTA 5JHUA 2OKNA 2BWWA 2GG5A 2NQ6A 1B6AA 1C21A 2OAZA 4U6ZA 2B3KA 2GG7A 4U6CA 4FO8A 3MX6A 2Q96A 2HOWA 1WL9A 2EVMA 1N51A 2Q93A 1JAWA 2Q95A 1BOAA 4IKUA 2G6PA 4B28A 5CIKA 5D6EA 2BH3A 1C22A 5CDEA 2BHBA 1QXZA 1KP0A 4IECA 1QZYA 5JI6A 1XGMA 2ZSGA 4S2RP 3FMQA 2P98A 1YW8A 2MATA 1YVMA 1O0XA 3PKEA 4KM3A 2V6CA 3IU9A 1WKMA 5JFRA 4U6WA 2GG8A 2GU7A 2EA4A 4U69A 3TAVA 2B3HA 3Q6DA 1WY2A 3MATA 1BN5A 4U75A 2BHCA 4FKCA 4HXXA 2BWXA 4S00A 4FLLA 2GGCA 2IW2A 4Z7MA 1YW7A 2EA2A 3S6BA 4QR8A 1WBQA 1W7VA 4R60A 1XGNA 3IG4A 2GG9A 1WLRA 1XNZA 2GGBA 2GU6A 2GG3A 2Q94A 2V3XA 4EGEA 3BIQA 1QXYA 3IU7A 2GG2A 2BB7A 1C24A 3PKDA 1R5HA 2BWVA 4S01A 4U70A 2NQ7A 3PKAA 3IU8A 1PV9A 4U76A 4U71A 4ZWOA 3RVAA 5CLSA 1KQ9A 2Q92A 1XGSA 4FLKA 1XGOA 1KQ0A 5FCFA 3L24A 1YJ3A 2P99A 1WN1A 5CDVA 1M35A 2EVCA 2Q8KA 2BHAA 4RGZ1 4FLIA 4U1BA 2BWUA 2GU5A 4OOKA 1Y1NA
chains in the Genus database with same CATH superfamily
4IKSA 4IU6A 3TB5A 4ZNGA 4U73A 2BWYA 3MR1A 4IF7A 2V3YA 2EVOA 1W2MA 1CHMA 1C23A 3FM3A 4PNCA 2GA2A 2B3LA 1C27A 5E5BA 4IPAA 4IKRA 3BITA 3PKBA 1B59A 4FUKA 2DFIA 4JUQA 4A6VA 4S2TP 3FMRA 2BHDA 5D6FA 1QXWA 4IDYA 5CDLA 4U6EA 5CE6A 2BWSA 3L7GA 3D27A 2GZ5A 2GG0A 4RZZA 4RZYA 1MATA 1A16A 5CNXA 4ZWPA 1YW9A 2BWTA 4U6JA 2GTXA 1R58A 2GU4A 1R5GA 3CB5A 2BN7A 3CTZA 3PKCA 2ADUA 3RORA 5FCHA 2V3ZA 4FO7A 4MATA 1WL6A 4PV4A 3CB6A 2P9AA 4A6WA 3BIPA 4ZWUA 4FLJA 4IKTA 5JHUA 2OKNA 2BWWA 2GG5A 2NQ6A 1B6AA 1C21A 2OAZA 4U6ZA 2B3KA 2GG7A 4U6CA 4FO8A 3MX6A 2Q96A 2HOWA 1WL9A 2EVMA 1N51A 2Q93A 1JAWA 2Q95A 1BOAA 4IKUA 2G6PA 4B28A 5CIKA 5D6EA 2BH3A 1C22A 5CDEA 2BHBA 1QXZA 1KP0A 4IECA 1QZYA 5JI6A 1XGMA 2ZSGA 4S2RP 3FMQA 2P98A 1YW8A 2MATA 1YVMA 1O0XA 3PKEA 4KM3A 2V6CA 3IU9A 1WKMA 5JFRA 4U6WA 2GG8A 2GU7A 2EA4A 4U69A 3TAVA 2B3HA 3Q6DA 1WY2A 3MATA 1BN5A 4U75A 2BHCA 4FKCA 4HXXA 2BWXA 4S00A 4FLLA 2GGCA 2IW2A 4Z7MA 1YW7A 2EA2A 3S6BA 4QR8A 1WBQA 1W7VA 4R60A 1XGNA 3IG4A 2GG9A 1WLRA 1XNZA 2GGBA 2GU6A 2GG3A 2Q94A 2V3XA 4EGEA 3BIQA 1QXYA 3IU7A 2GG2A 2BB7A 1C24A 3PKDA 1R5HA 2BWVA 4S01A 4U70A 2NQ7A 3PKAA 3IU8A 1PV9A 4U76A 4U71A 4ZWOA 3RVAA 5CLSA 1KQ9A 2Q92A 1XGSA 4FLKA 1XGOA 1KQ0A 5FCFA 3L24A 1YJ3A 2P99A 1WN1A 5CDVA 1M35A 2EVCA 2Q8KA 2BHAA 4RGZ1 4FLIA 4U1BA 2BWUA 2GU5A 4OOKA 1Y1NA
chains in the Genus database with same CATH topology
4IKSA 4IU6A 3TB5A 4ZNGA 4U73A 2BWYA 3MR1A 4IF7A 2V3YA 2EVOA 1W2MA 1CHMA 1C23A 3FM3A 4PNCA 2GA2A 2B3LA 1C27A 5E5BA 4IPAA 4IKRA 3BITA 3PKBA 1B59A 4FUKA 2DFIA 4JUQA 4A6VA 4S2TP 3FMRA 2BHDA 5D6FA 1QXWA 4IDYA 5CDLA 4U6EA 5CE6A 2BWSA 3L7GA 3D27A 2GZ5A 2GG0A 4RZZA 4RZYA 1MATA 1A16A 5CNXA 4ZWPA 1YW9A 2BWTA 4U6JA 2GTXA 1R58A 2GU4A 1R5GA 3CB5A 2BN7A 3CTZA 3PKCA 2ADUA 3RORA 5FCHA 2V3ZA 4FO7A 4MATA 1WL6A 4PV4A 3CB6A 2P9AA 4A6WA 3BIPA 4ZWUA 4FLJA 4IKTA 5JHUA 2OKNA 2BWWA 2GG5A 2NQ6A 1B6AA 1C21A 2OAZA 4U6ZA 2B3KA 2GG7A 4U6CA 4FO8A 3MX6A 2Q96A 2HOWA 1WL9A 2EVMA 1N51A 2Q93A 1JAWA 2Q95A 1BOAA 4IKUA 2G6PA 4B28A 5CIKA 5D6EA 2BH3A 1C22A 5CDEA 2BHBA 1QXZA 1KP0A 4IECA 1QZYA 5JI6A 1XGMA 2ZSGA 4S2RP 3FMQA 2P98A 1YW8A 2MATA 1YVMA 1O0XA 3PKEA 4KM3A 2V6CA 3IU9A 1WKMA 5JFRA 4U6WA 2GG8A 2GU7A 2EA4A 4U69A 3TAVA 2B3HA 3Q6DA 1WY2A 3MATA 1BN5A 4U75A 2BHCA 4FKCA 4HXXA 2BWXA 4S00A 4FLLA 2GGCA 2IW2A 4Z7MA 1YW7A 2EA2A 3S6BA 4QR8A 1WBQA 1W7VA 4R60A 1XGNA 3IG4A 2GG9A 1WLRA 1XNZA 2GGBA 2GU6A 2GG3A 2Q94A 2V3XA 4EGEA 3BIQA 1QXYA 3IU7A 2GG2A 2BB7A 1C24A 3PKDA 1R5HA 2BWVA 4S01A 4U70A 2NQ7A 3PKAA 3IU8A 1PV9A 4U76A 4U71A 4ZWOA 3RVAA 5CLSA 1KQ9A 2Q92A 1XGSA 4FLKA 1XGOA 1KQ0A 5FCFA 3L24A 1YJ3A 2P99A 1WN1A 5CDVA 1M35A 2EVCA 2Q8KA 2BHAA 4RGZ1 4FLIA 4U1BA 2BWUA 2GU5A 4OOKA 1Y1NA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4IKS A;  4IU6 A;  3TB5 A;  4ZNG A;  4U73 A;  2BWY A;  3MR1 A;  4IF7 A;  2V3Y A;  2EVO A;  1W2M A;  1CHM A;  1C23 A;  3FM3 A;  4PNC A;  2GA2 A;  2B3L A;  1C27 A;  5E5B A;  4IPA A;  4IKR A;  3BIT A;  3PKB A;  1B59 A;  4FUK A;  2DFI A;  4JUQ A;  4A6V A;  4S2T P;  3FMR A;  2BHD A;  5D6F A;  1QXW A;  4IDY A;  5CDL A;  4U6E A;  5CE6 A;  2BWS A;  3L7G A;  3D27 A;  2GZ5 A;  2GG0 A;  4RZZ A;  4RZY A;  1MAT A;  1A16 A;  5CNX A;  4ZWP A;  1YW9 A;  2BWT A;  4U6J A;  2GTX A;  1R58 A;  2GU4 A;  1R5G A;  3CB5 A;  2BN7 A;  3CTZ A;  3PKC A;  2ADU A;  3ROR A;  5FCH A;  2V3Z A;  4FO7 A;  4MAT A;  1WL6 A;  4PV4 A;  3CB6 A;  2P9A A;  4A6W A;  3BIP A;  4ZWU A;  4FLJ A;  4IKT A;  5JHU A;  2OKN A;  2BWW A;  2GG5 A;  2NQ6 A;  1B6A A;  1C21 A;  2OAZ A;  4U6Z A;  2B3K A;  2GG7 A;  4U6C A;  4FO8 A;  3MX6 A;  2Q96 A;  2HOW A;  1WL9 A;  2EVM A;  1N51 A;  2Q93 A;  1JAW A;  2Q95 A;  1BOA A;  4IKU A;  2G6P A;  4B28 A;  5CIK A;  5D6E A;  2BH3 A;  1C22 A;  5CDE A;  2BHB A;  1QXZ A;  1KP0 A;  4IEC A;  1QZY A;  5JI6 A;  1XGM A;  2ZSG A;  4S2R P;  3FMQ A;  2P98 A;  1YW8 A;  2MAT A;  1YVM A;  1O0X A;  3PKE A;  4KM3 A;  2V6C A;  3IU9 A;  1WKM A;  5JFR A;  4U6W A;  2GG8 A;  2GU7 A;  2EA4 A;  4U69 A;  3TAV A;  2B3H A;  3Q6D A;  1WY2 A;  3MAT A;  1BN5 A;  4U75 A;  2BHC A;  4FKC A;  4HXX A;  2BWX A;  4S00 A;  4FLL A;  2GGC A;  2IW2 A;  4Z7M A;  1YW7 A;  2EA2 A;  3S6B A;  4QR8 A;  1WBQ A;  1W7V A;  4R60 A;  1XGN A;  3IG4 A;  2GG9 A;  1WLR A;  1XNZ A;  2GGB A;  2GU6 A;  2GG3 A;  2Q94 A;  2V3X A;  4EGE A;  3BIQ A;  1QXY A;  3IU7 A;  2GG2 A;  2BB7 A;  1C24 A;  3PKD A;  1R5H A;  2BWV A;  4S01 A;  4U70 A;  2NQ7 A;  3PKA A;  3IU8 A;  1PV9 A;  4U76 A;  4U71 A;  4ZWO A;  3RVA A;  5CLS A;  1KQ9 A;  2Q92 A;  1XGS A;  4FLK A;  1XGO A;  1KQ0 A;  5FCF A;  3L24 A;  1YJ3 A;  2P99 A;  1WN1 A;  5CDV A;  1M35 A;  2EVC A;  2Q8K A;  2BHA A;  4RGZ 1;  4FLI A;  4U1B A;  2BWU A;  2GU5 A;  4OOK A;  1Y1N A; 
#chains in the Genus database with same CATH topology
 4IKS A;  4IU6 A;  3TB5 A;  4ZNG A;  4U73 A;  2BWY A;  3MR1 A;  4IF7 A;  2V3Y A;  2EVO A;  1W2M A;  1CHM A;  1C23 A;  3FM3 A;  4PNC A;  2GA2 A;  2B3L A;  1C27 A;  5E5B A;  4IPA A;  4IKR A;  3BIT A;  3PKB A;  1B59 A;  4FUK A;  2DFI A;  4JUQ A;  4A6V A;  4S2T P;  3FMR A;  2BHD A;  5D6F A;  1QXW A;  4IDY A;  5CDL A;  4U6E A;  5CE6 A;  2BWS A;  3L7G A;  3D27 A;  2GZ5 A;  2GG0 A;  4RZZ A;  4RZY A;  1MAT A;  1A16 A;  5CNX A;  4ZWP A;  1YW9 A;  2BWT A;  4U6J A;  2GTX A;  1R58 A;  2GU4 A;  1R5G A;  3CB5 A;  2BN7 A;  3CTZ A;  3PKC A;  2ADU A;  3ROR A;  5FCH A;  2V3Z A;  4FO7 A;  4MAT A;  1WL6 A;  4PV4 A;  3CB6 A;  2P9A A;  4A6W A;  3BIP A;  4ZWU A;  4FLJ A;  4IKT A;  5JHU A;  2OKN A;  2BWW A;  2GG5 A;  2NQ6 A;  1B6A A;  1C21 A;  2OAZ A;  4U6Z A;  2B3K A;  2GG7 A;  4U6C A;  4FO8 A;  3MX6 A;  2Q96 A;  2HOW A;  1WL9 A;  2EVM A;  1N51 A;  2Q93 A;  1JAW A;  2Q95 A;  1BOA A;  4IKU A;  2G6P A;  4B28 A;  5CIK A;  5D6E A;  2BH3 A;  1C22 A;  5CDE A;  2BHB A;  1QXZ A;  1KP0 A;  4IEC A;  1QZY A;  5JI6 A;  1XGM A;  2ZSG A;  4S2R P;  3FMQ A;  2P98 A;  1YW8 A;  2MAT A;  1YVM A;  1O0X A;  3PKE A;  4KM3 A;  2V6C A;  3IU9 A;  1WKM A;  5JFR A;  4U6W A;  2GG8 A;  2GU7 A;  2EA4 A;  4U69 A;  3TAV A;  2B3H A;  3Q6D A;  1WY2 A;  3MAT A;  1BN5 A;  4U75 A;  2BHC A;  4FKC A;  4HXX A;  2BWX A;  4S00 A;  4FLL A;  2GGC A;  2IW2 A;  4Z7M A;  1YW7 A;  2EA2 A;  3S6B A;  4QR8 A;  1WBQ A;  1W7V A;  4R60 A;  1XGN A;  3IG4 A;  2GG9 A;  1WLR A;  1XNZ A;  2GGB A;  2GU6 A;  2GG3 A;  2Q94 A;  2V3X A;  4EGE A;  3BIQ A;  1QXY A;  3IU7 A;  2GG2 A;  2BB7 A;  1C24 A;  3PKD A;  1R5H A;  2BWV A;  4S01 A;  4U70 A;  2NQ7 A;  3PKA A;  3IU8 A;  1PV9 A;  4U76 A;  4U71 A;  4ZWO A;  3RVA A;  5CLS A;  1KQ9 A;  2Q92 A;  1XGS A;  4FLK A;  1XGO A;  1KQ0 A;  5FCF A;  3L24 A;  1YJ3 A;  2P99 A;  1WN1 A;  5CDV A;  1M35 A;  2EVC A;  2Q8K A;  2BHA A;  4RGZ 1;  4FLI A;  4U1B A;  2BWU A;  2GU5 A;  4OOK A;  1Y1N A; 
#chains in the Genus database with same CATH homology
 4IKS A;  4IU6 A;  3TB5 A;  4ZNG A;  4U73 A;  2BWY A;  3MR1 A;  4IF7 A;  2V3Y A;  2EVO A;  1W2M A;  1CHM A;  1C23 A;  3FM3 A;  4PNC A;  2GA2 A;  2B3L A;  1C27 A;  5E5B A;  4IPA A;  4IKR A;  3BIT A;  3PKB A;  1B59 A;  4FUK A;  2DFI A;  4JUQ A;  4A6V A;  4S2T P;  3FMR A;  2BHD A;  5D6F A;  1QXW A;  4IDY A;  5CDL A;  4U6E A;  5CE6 A;  2BWS A;  3L7G A;  3D27 A;  2GZ5 A;  2GG0 A;  4RZZ A;  4RZY A;  1MAT A;  1A16 A;  5CNX A;  4ZWP A;  1YW9 A;  2BWT A;  4U6J A;  2GTX A;  1R58 A;  2GU4 A;  1R5G A;  3CB5 A;  2BN7 A;  3CTZ A;  3PKC A;  2ADU A;  3ROR A;  5FCH A;  2V3Z A;  4FO7 A;  4MAT A;  1WL6 A;  4PV4 A;  3CB6 A;  2P9A A;  4A6W A;  3BIP A;  4ZWU A;  4FLJ A;  4IKT A;  5JHU A;  2OKN A;  2BWW A;  2GG5 A;  2NQ6 A;  1B6A A;  1C21 A;  2OAZ A;  4U6Z A;  2B3K A;  2GG7 A;  4U6C A;  4FO8 A;  3MX6 A;  2Q96 A;  2HOW A;  1WL9 A;  2EVM A;  1N51 A;  2Q93 A;  1JAW A;  2Q95 A;  1BOA A;  4IKU A;  2G6P A;  4B28 A;  5CIK A;  5D6E A;  2BH3 A;  1C22 A;  5CDE A;  2BHB A;  1QXZ A;  1KP0 A;  4IEC A;  1QZY A;  5JI6 A;  1XGM A;  2ZSG A;  4S2R P;  3FMQ A;  2P98 A;  1YW8 A;  2MAT A;  1YVM A;  1O0X A;  3PKE A;  4KM3 A;  2V6C A;  3IU9 A;  1WKM A;  5JFR A;  4U6W A;  2GG8 A;  2GU7 A;  2EA4 A;  4U69 A;  3TAV A;  2B3H A;  3Q6D A;  1WY2 A;  3MAT A;  1BN5 A;  4U75 A;  2BHC A;  4FKC A;  4HXX A;  2BWX A;  4S00 A;  4FLL A;  2GGC A;  2IW2 A;  4Z7M A;  1YW7 A;  2EA2 A;  3S6B A;  4QR8 A;  1WBQ A;  1W7V A;  4R60 A;  1XGN A;  3IG4 A;  2GG9 A;  1WLR A;  1XNZ A;  2GGB A;  2GU6 A;  2GG3 A;  2Q94 A;  2V3X A;  4EGE A;  3BIQ A;  1QXY A;  3IU7 A;  2GG2 A;  2BB7 A;  1C24 A;  3PKD A;  1R5H A;  2BWV A;  4S01 A;  4U70 A;  2NQ7 A;  3PKA A;  3IU8 A;  1PV9 A;  4U76 A;  4U71 A;  4ZWO A;  3RVA A;  5CLS A;  1KQ9 A;  2Q92 A;  1XGS A;  4FLK A;  1XGO A;  1KQ0 A;  5FCF A;  3L24 A;  1YJ3 A;  2P99 A;  1WN1 A;  5CDV A;  1M35 A;  2EVC A;  2Q8K A;  2BHA A;  4RGZ 1;  4FLI A;  4U1B A;  2BWU A;  2GU5 A;  4OOK A;  1Y1N A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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