4U6JA

Hsmetap in complex with methionine
Total Genus 102
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
4U76A 3MX6A 3PKAA 1XGNA 2BWVA 4R60A 1XGMA 4A6VA 3IG4A 2NQ7A 4S00A 1WN1A 4KM3A 5JHUA 4U71A 1WL6A 4S01A 1CHMA 4FKCA 2ADUA 5CDVA 1KQ9A 3FMRA 2EVMA 4A6WA 2Q8KA 5CE6A 2BWUA 1YJ3A 1C21A 4FO8A 2OAZA 5E5BA 2BB7A 1O0XA 3CB6A 2P9AA 2NQ6A 4ZWOA 4U6JA 2BWTA 1R5GA 4S2RP 3IU7A 2Q96A 3RORA 4IKSA 2V3YA 4EGEA 1KP0A 2GG9A 5JFRA 2GTXA 4RGZ1 2GU4A 4ZNGA 5FCHA 1XGOA 1YW8A 2IW2A 4RZYA 1QXYA 3FM3A 1BOAA 1C22A 1XNZA 4ZWPA 2P98A 3S6BA 2MATA 3TB5A 4S2TP 1MATA 1JAWA 2EA4A 2B3HA 3FMQA 2OKNA 4U1BA 2GZ5A 1WBQA 1N51A 4FO7A 4U6EA 2BHDA 2Q95A 4PNCA 3PKCA 1R5HA 4FLKA 4Z7MA 1KQ0A 1QZYA 2EVOA 4HXXA 4JUQA 4IU6A 4MATA 1A16A 3BIQA 4FLLA 1PV9A 3PKDA 3L24A 2BWXA 3Q6DA 4U6CA 2P99A 2V3ZA 1M35A 5CIKA 2V6CA 2GG2A 5CLSA 5D6EA 2Q92A 3MR1A 3L7GA 4FUKA 2BH3A 1C23A 2BWSA 1W7VA 2GU7A 5FCFA 2V3XA 3PKEA 1XGSA 2GG8A 4IECA 1WKMA 2GG7A 2EVCA 1WY2A 4IDYA 4IKTA 4ZWUA 2GGBA 3BIPA 2Q93A 4PV4A 1Y1NA 4IF7A 2BHBA 5JI6A 3IU9A 2HOWA 5CNXA 3BITA 2BWYA 3D27A 3IU8A 5CDLA 2BN7A 3PKBA 2BWWA 4IKRA 1R58A 2DFIA 2GG3A 4U73A 2GGCA 2G6PA 2BHCA 1WLRA 1YW9A 2GG0A 4U75A 4IPAA 2Q94A 1WL9A 2GA2A 3RVAA 4B28A 4FLIA 4QR8A 3CTZA 4U69A 2BHAA 4OOKA 1QXZA 1W2MA 4U6ZA 1B6AA 1YW7A 2GU6A 5CDEA 3TAVA 2GU5A 2GG5A 5D6FA 1BN5A 4U6WA 4RZZA 1C24A 2B3LA 2B3KA 3CB5A 1YVMA 3MATA 1QXWA 1C27A 1B59A 4U70A 2ZSGA 4IKUA 4FLJA 2EA2A
chains in the Genus database with same CATH superfamily
4U76A 3MX6A 3PKAA 1XGNA 2BWVA 4R60A 1XGMA 4A6VA 3IG4A 2NQ7A 4S00A 1WN1A 4KM3A 5JHUA 4U71A 1WL6A 4S01A 1CHMA 4FKCA 2ADUA 5CDVA 1KQ9A 3FMRA 2EVMA 4A6WA 2Q8KA 5CE6A 2BWUA 1YJ3A 1C21A 4FO8A 2OAZA 5E5BA 2BB7A 1O0XA 3CB6A 2P9AA 2NQ6A 4ZWOA 4U6JA 2BWTA 1R5GA 4S2RP 3IU7A 2Q96A 3RORA 4IKSA 2V3YA 4EGEA 1KP0A 2GG9A 5JFRA 2GTXA 4RGZ1 2GU4A 4ZNGA 5FCHA 1XGOA 1YW8A 2IW2A 4RZYA 1QXYA 3FM3A 1BOAA 1C22A 1XNZA 4ZWPA 2P98A 3S6BA 2MATA 3TB5A 4S2TP 1MATA 1JAWA 2EA4A 2B3HA 3FMQA 2OKNA 4U1BA 2GZ5A 1WBQA 1N51A 4FO7A 4U6EA 2BHDA 2Q95A 4PNCA 3PKCA 1R5HA 4FLKA 4Z7MA 1KQ0A 1QZYA 2EVOA 4HXXA 4JUQA 4IU6A 4MATA 1A16A 3BIQA 4FLLA 1PV9A 3PKDA 3L24A 2BWXA 3Q6DA 4U6CA 2P99A 2V3ZA 1M35A 5CIKA 2V6CA 2GG2A 5CLSA 5D6EA 2Q92A 3MR1A 3L7GA 4FUKA 2BH3A 1C23A 2BWSA 1W7VA 2GU7A 5FCFA 2V3XA 3PKEA 1XGSA 2GG8A 4IECA 1WKMA 2GG7A 2EVCA 1WY2A 4IDYA 4IKTA 4ZWUA 2GGBA 3BIPA 2Q93A 4PV4A 1Y1NA 4IF7A 2BHBA 5JI6A 3IU9A 2HOWA 5CNXA 3BITA 2BWYA 3D27A 3IU8A 5CDLA 2BN7A 3PKBA 2BWWA 4IKRA 1R58A 2DFIA 2GG3A 4U73A 2GGCA 2G6PA 2BHCA 1WLRA 1YW9A 2GG0A 4U75A 4IPAA 2Q94A 1WL9A 2GA2A 3RVAA 4B28A 4FLIA 4QR8A 3CTZA 4U69A 2BHAA 4OOKA 1QXZA 1W2MA 4U6ZA 1B6AA 1YW7A 2GU6A 5CDEA 3TAVA 2GU5A 2GG5A 5D6FA 1BN5A 4U6WA 4RZZA 1C24A 2B3LA 2B3KA 3CB5A 1YVMA 3MATA 1QXWA 1C27A 1B59A 4U70A 2ZSGA 4IKUA 4FLJA 2EA2A
chains in the Genus database with same CATH topology
4U76A 3MX6A 3PKAA 1XGNA 2BWVA 4R60A 1XGMA 4A6VA 3IG4A 2NQ7A 4S00A 1WN1A 4KM3A 5JHUA 4U71A 1WL6A 4S01A 1CHMA 4FKCA 2ADUA 5CDVA 1KQ9A 3FMRA 2EVMA 4A6WA 2Q8KA 5CE6A 2BWUA 1YJ3A 1C21A 4FO8A 2OAZA 5E5BA 2BB7A 1O0XA 3CB6A 2P9AA 2NQ6A 4ZWOA 4U6JA 2BWTA 1R5GA 4S2RP 3IU7A 2Q96A 3RORA 4IKSA 2V3YA 4EGEA 1KP0A 2GG9A 5JFRA 2GTXA 4RGZ1 2GU4A 4ZNGA 5FCHA 1XGOA 1YW8A 2IW2A 4RZYA 1QXYA 3FM3A 1BOAA 1C22A 1XNZA 4ZWPA 2P98A 3S6BA 2MATA 3TB5A 4S2TP 1MATA 1JAWA 2EA4A 2B3HA 3FMQA 2OKNA 4U1BA 2GZ5A 1WBQA 1N51A 4FO7A 4U6EA 2BHDA 2Q95A 4PNCA 3PKCA 1R5HA 4FLKA 4Z7MA 1KQ0A 1QZYA 2EVOA 4HXXA 4JUQA 4IU6A 4MATA 1A16A 3BIQA 4FLLA 1PV9A 3PKDA 3L24A 2BWXA 3Q6DA 4U6CA 2P99A 2V3ZA 1M35A 5CIKA 2V6CA 2GG2A 5CLSA 5D6EA 2Q92A 3MR1A 3L7GA 4FUKA 2BH3A 1C23A 2BWSA 1W7VA 2GU7A 5FCFA 2V3XA 3PKEA 1XGSA 2GG8A 4IECA 1WKMA 2GG7A 2EVCA 1WY2A 4IDYA 4IKTA 4ZWUA 2GGBA 3BIPA 2Q93A 4PV4A 1Y1NA 4IF7A 2BHBA 5JI6A 3IU9A 2HOWA 5CNXA 3BITA 2BWYA 3D27A 3IU8A 5CDLA 2BN7A 3PKBA 2BWWA 4IKRA 1R58A 2DFIA 2GG3A 4U73A 2GGCA 2G6PA 2BHCA 1WLRA 1YW9A 2GG0A 4U75A 4IPAA 2Q94A 1WL9A 2GA2A 3RVAA 4B28A 4FLIA 4QR8A 3CTZA 4U69A 2BHAA 4OOKA 1QXZA 1W2MA 4U6ZA 1B6AA 1YW7A 2GU6A 5CDEA 3TAVA 2GU5A 2GG5A 5D6FA 1BN5A 4U6WA 4RZZA 1C24A 2B3LA 2B3KA 3CB5A 1YVMA 3MATA 1QXWA 1C27A 1B59A 4U70A 2ZSGA 4IKUA 4FLJA 2EA2A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4U76 A;  3MX6 A;  3PKA A;  1XGN A;  2BWV A;  4R60 A;  1XGM A;  4A6V A;  3IG4 A;  2NQ7 A;  4S00 A;  1WN1 A;  4KM3 A;  5JHU A;  4U71 A;  1WL6 A;  4S01 A;  1CHM A;  4FKC A;  2ADU A;  5CDV A;  1KQ9 A;  3FMR A;  2EVM A;  4A6W A;  2Q8K A;  5CE6 A;  2BWU A;  1YJ3 A;  1C21 A;  4FO8 A;  2OAZ A;  5E5B A;  2BB7 A;  1O0X A;  3CB6 A;  2P9A A;  2NQ6 A;  4ZWO A;  4U6J A;  2BWT A;  1R5G A;  4S2R P;  3IU7 A;  2Q96 A;  3ROR A;  4IKS A;  2V3Y A;  4EGE A;  1KP0 A;  2GG9 A;  5JFR A;  2GTX A;  4RGZ 1;  2GU4 A;  4ZNG A;  5FCH A;  1XGO A;  1YW8 A;  2IW2 A;  4RZY A;  1QXY A;  3FM3 A;  1BOA A;  1C22 A;  1XNZ A;  4ZWP A;  2P98 A;  3S6B A;  2MAT A;  3TB5 A;  4S2T P;  1MAT A;  1JAW A;  2EA4 A;  2B3H A;  3FMQ A;  2OKN A;  4U1B A;  2GZ5 A;  1WBQ A;  1N51 A;  4FO7 A;  4U6E A;  2BHD A;  2Q95 A;  4PNC A;  3PKC A;  1R5H A;  4FLK A;  4Z7M A;  1KQ0 A;  1QZY A;  2EVO A;  4HXX A;  4JUQ A;  4IU6 A;  4MAT A;  1A16 A;  3BIQ A;  4FLL A;  1PV9 A;  3PKD A;  3L24 A;  2BWX A;  3Q6D A;  4U6C A;  2P99 A;  2V3Z A;  1M35 A;  5CIK A;  2V6C A;  2GG2 A;  5CLS A;  5D6E A;  2Q92 A;  3MR1 A;  3L7G A;  4FUK A;  2BH3 A;  1C23 A;  2BWS A;  1W7V A;  2GU7 A;  5FCF A;  2V3X A;  3PKE A;  1XGS A;  2GG8 A;  4IEC A;  1WKM A;  2GG7 A;  2EVC A;  1WY2 A;  4IDY A;  4IKT A;  4ZWU A;  2GGB A;  3BIP A;  2Q93 A;  4PV4 A;  1Y1N A;  4IF7 A;  2BHB A;  5JI6 A;  3IU9 A;  2HOW A;  5CNX A;  3BIT A;  2BWY A;  3D27 A;  3IU8 A;  5CDL A;  2BN7 A;  3PKB A;  2BWW A;  4IKR A;  1R58 A;  2DFI A;  2GG3 A;  4U73 A;  2GGC A;  2G6P A;  2BHC A;  1WLR A;  1YW9 A;  2GG0 A;  4U75 A;  4IPA A;  2Q94 A;  1WL9 A;  2GA2 A;  3RVA A;  4B28 A;  4FLI A;  4QR8 A;  3CTZ A;  4U69 A;  2BHA A;  4OOK A;  1QXZ A;  1W2M A;  4U6Z A;  1B6A A;  1YW7 A;  2GU6 A;  5CDE A;  3TAV A;  2GU5 A;  2GG5 A;  5D6F A;  1BN5 A;  4U6W A;  4RZZ A;  1C24 A;  2B3L A;  2B3K A;  3CB5 A;  1YVM A;  3MAT A;  1QXW A;  1C27 A;  1B59 A;  4U70 A;  2ZSG A;  4IKU A;  4FLJ A;  2EA2 A; 
#chains in the Genus database with same CATH topology
 4U76 A;  3MX6 A;  3PKA A;  1XGN A;  2BWV A;  4R60 A;  1XGM A;  4A6V A;  3IG4 A;  2NQ7 A;  4S00 A;  1WN1 A;  4KM3 A;  5JHU A;  4U71 A;  1WL6 A;  4S01 A;  1CHM A;  4FKC A;  2ADU A;  5CDV A;  1KQ9 A;  3FMR A;  2EVM A;  4A6W A;  2Q8K A;  5CE6 A;  2BWU A;  1YJ3 A;  1C21 A;  4FO8 A;  2OAZ A;  5E5B A;  2BB7 A;  1O0X A;  3CB6 A;  2P9A A;  2NQ6 A;  4ZWO A;  4U6J A;  2BWT A;  1R5G A;  4S2R P;  3IU7 A;  2Q96 A;  3ROR A;  4IKS A;  2V3Y A;  4EGE A;  1KP0 A;  2GG9 A;  5JFR A;  2GTX A;  4RGZ 1;  2GU4 A;  4ZNG A;  5FCH A;  1XGO A;  1YW8 A;  2IW2 A;  4RZY A;  1QXY A;  3FM3 A;  1BOA A;  1C22 A;  1XNZ A;  4ZWP A;  2P98 A;  3S6B A;  2MAT A;  3TB5 A;  4S2T P;  1MAT A;  1JAW A;  2EA4 A;  2B3H A;  3FMQ A;  2OKN A;  4U1B A;  2GZ5 A;  1WBQ A;  1N51 A;  4FO7 A;  4U6E A;  2BHD A;  2Q95 A;  4PNC A;  3PKC A;  1R5H A;  4FLK A;  4Z7M A;  1KQ0 A;  1QZY A;  2EVO A;  4HXX A;  4JUQ A;  4IU6 A;  4MAT A;  1A16 A;  3BIQ A;  4FLL A;  1PV9 A;  3PKD A;  3L24 A;  2BWX A;  3Q6D A;  4U6C A;  2P99 A;  2V3Z A;  1M35 A;  5CIK A;  2V6C A;  2GG2 A;  5CLS A;  5D6E A;  2Q92 A;  3MR1 A;  3L7G A;  4FUK A;  2BH3 A;  1C23 A;  2BWS A;  1W7V A;  2GU7 A;  5FCF A;  2V3X A;  3PKE A;  1XGS A;  2GG8 A;  4IEC A;  1WKM A;  2GG7 A;  2EVC A;  1WY2 A;  4IDY A;  4IKT A;  4ZWU A;  2GGB A;  3BIP A;  2Q93 A;  4PV4 A;  1Y1N A;  4IF7 A;  2BHB A;  5JI6 A;  3IU9 A;  2HOW A;  5CNX A;  3BIT A;  2BWY A;  3D27 A;  3IU8 A;  5CDL A;  2BN7 A;  3PKB A;  2BWW A;  4IKR A;  1R58 A;  2DFI A;  2GG3 A;  4U73 A;  2GGC A;  2G6P A;  2BHC A;  1WLR A;  1YW9 A;  2GG0 A;  4U75 A;  4IPA A;  2Q94 A;  1WL9 A;  2GA2 A;  3RVA A;  4B28 A;  4FLI A;  4QR8 A;  3CTZ A;  4U69 A;  2BHA A;  4OOK A;  1QXZ A;  1W2M A;  4U6Z A;  1B6A A;  1YW7 A;  2GU6 A;  5CDE A;  3TAV A;  2GU5 A;  2GG5 A;  5D6F A;  1BN5 A;  4U6W A;  4RZZ A;  1C24 A;  2B3L A;  2B3K A;  3CB5 A;  1YVM A;  3MAT A;  1QXW A;  1C27 A;  1B59 A;  4U70 A;  2ZSG A;  4IKU A;  4FLJ A;  2EA2 A; 
#chains in the Genus database with same CATH homology
 4U76 A;  3MX6 A;  3PKA A;  1XGN A;  2BWV A;  4R60 A;  1XGM A;  4A6V A;  3IG4 A;  2NQ7 A;  4S00 A;  1WN1 A;  4KM3 A;  5JHU A;  4U71 A;  1WL6 A;  4S01 A;  1CHM A;  4FKC A;  2ADU A;  5CDV A;  1KQ9 A;  3FMR A;  2EVM A;  4A6W A;  2Q8K A;  5CE6 A;  2BWU A;  1YJ3 A;  1C21 A;  4FO8 A;  2OAZ A;  5E5B A;  2BB7 A;  1O0X A;  3CB6 A;  2P9A A;  2NQ6 A;  4ZWO A;  4U6J A;  2BWT A;  1R5G A;  4S2R P;  3IU7 A;  2Q96 A;  3ROR A;  4IKS A;  2V3Y A;  4EGE A;  1KP0 A;  2GG9 A;  5JFR A;  2GTX A;  4RGZ 1;  2GU4 A;  4ZNG A;  5FCH A;  1XGO A;  1YW8 A;  2IW2 A;  4RZY A;  1QXY A;  3FM3 A;  1BOA A;  1C22 A;  1XNZ A;  4ZWP A;  2P98 A;  3S6B A;  2MAT A;  3TB5 A;  4S2T P;  1MAT A;  1JAW A;  2EA4 A;  2B3H A;  3FMQ A;  2OKN A;  4U1B A;  2GZ5 A;  1WBQ A;  1N51 A;  4FO7 A;  4U6E A;  2BHD A;  2Q95 A;  4PNC A;  3PKC A;  1R5H A;  4FLK A;  4Z7M A;  1KQ0 A;  1QZY A;  2EVO A;  4HXX A;  4JUQ A;  4IU6 A;  4MAT A;  1A16 A;  3BIQ A;  4FLL A;  1PV9 A;  3PKD A;  3L24 A;  2BWX A;  3Q6D A;  4U6C A;  2P99 A;  2V3Z A;  1M35 A;  5CIK A;  2V6C A;  2GG2 A;  5CLS A;  5D6E A;  2Q92 A;  3MR1 A;  3L7G A;  4FUK A;  2BH3 A;  1C23 A;  2BWS A;  1W7V A;  2GU7 A;  5FCF A;  2V3X A;  3PKE A;  1XGS A;  2GG8 A;  4IEC A;  1WKM A;  2GG7 A;  2EVC A;  1WY2 A;  4IDY A;  4IKT A;  4ZWU A;  2GGB A;  3BIP A;  2Q93 A;  4PV4 A;  1Y1N A;  4IF7 A;  2BHB A;  5JI6 A;  3IU9 A;  2HOW A;  5CNX A;  3BIT A;  2BWY A;  3D27 A;  3IU8 A;  5CDL A;  2BN7 A;  3PKB A;  2BWW A;  4IKR A;  1R58 A;  2DFI A;  2GG3 A;  4U73 A;  2GGC A;  2G6P A;  2BHC A;  1WLR A;  1YW9 A;  2GG0 A;  4U75 A;  4IPA A;  2Q94 A;  1WL9 A;  2GA2 A;  3RVA A;  4B28 A;  4FLI A;  4QR8 A;  3CTZ A;  4U69 A;  2BHA A;  4OOK A;  1QXZ A;  1W2M A;  4U6Z A;  1B6A A;  1YW7 A;  2GU6 A;  5CDE A;  3TAV A;  2GU5 A;  2GG5 A;  5D6F A;  1BN5 A;  4U6W A;  4RZZ A;  1C24 A;  2B3L A;  2B3K A;  3CB5 A;  1YVM A;  3MAT A;  1QXW A;  1C27 A;  1B59 A;  4U70 A;  2ZSG A;  4IKU A;  4FLJ A;  2EA2 A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite