4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
4A6VA 5CIKA 4ZNGA 1XGMA 2GU5A 2NQ7A 1XGNA 2GA2A 2GG8A 3FM3A 1W7VA 3BIPA 3IU8A 2Q8KA 5CE6A 2EA4A 2GG3A 3IU9A 5JHUA 4PV4A 3MATA 4U75A 2IW2A 3FMRA 2Q94A 5CDLA 1YVMA 3PKBA 3CB5A 2B3HA 3RVAA 3FMQA 2EVMA 1WN1A 2V3ZA 4S2RP 4U6EA 1R5GA 4FO8A 1KQ0A 2EVCA 4IDYA 4U71A 4IKTA 2B3KA 4U70A 4HXXA 1XGOA 2EA2A 1WL9A 5E5BA 4IF7A 4FLIA 3PKAA 3PKEA 4ZWPA 3MR1A 1XGSA 3MX6A 4FLLA 4U1BA 4U6ZA 2P98A 3PKDA 1QZYA 1WKMA 4IPAA 4U73A 4IU6A 1A16A 1XNZA 4U6WA 5JI6A 4U76A 3PKCA 2G6PA 2BHAA 3TB5A 1KQ9A 1YW7A 2NQ6A 2B3LA 4FO7A 2GU4A 2GGBA 4RZYA 3TAVA 1BN5A 1B59A 1W2MA 4S01A 4FKCA 2BWWA 2ZSGA 2BHCA 5CLSA 1O0XA 4KM3A 1JAWA 3Q6DA 1C23A 2ADUA 2OKNA 4FUKA 1C21A 1YW8A 4IECA 1C24A 1YW9A 4JUQA 4R60A 3BITA 4ZWUA 1WLRA 3S6BA 2V6CA 2V3YA 1KP0A 3CB6A 4ZWOA 2Q93A 3IU7A 1C27A 1C22A 2DFIA 3L24A 1MATA 1QXYA 1YJ3A 2BWVA 4U6CA 2BHDA 3RORA 4U69A 2GGCA 1CHMA 3CTZA 5FCFA 2GG0A 4S00A 4S2TP 4EGEA 2GG9A 5CDEA 4PNCA 1WL6A 2GG5A 1BOAA 2HOWA 4Z7MA 5JFRA 2BWYA 2GZ5A 2GG7A 2Q96A 2BWUA 2OAZA 1QXZA 2BWTA 1WY2A 1R5HA 2MATA 4OOKA 3L7GA 2P9AA 4U6JA 4A6WA 4QR8A 1B6AA 4IKUA 1WBQA 1M35A 5D6FA 5FCHA 2BHBA 4FLJA 4FLKA 1PV9A 2GTXA 2GG2A 2GU6A 3BIQA 2V3XA 3IG4A 5CNXA 2BB7A 1QXWA 4B28A 2EVOA 4RGZ1 4IKRA 3D27A 4MATA 4RZZA 2P99A 1Y1NA 2GU7A 2Q95A 2Q92A 2BN7A 1N51A 4IKSA 5CDVA 2BWXA 1R58A 5D6EA 2BH3A 2BWSA
chains in the Genus database with same CATH superfamily
4A6VA 5CIKA 4ZNGA 1XGMA 2GU5A 2NQ7A 1XGNA 2GA2A 2GG8A 3FM3A 1W7VA 3BIPA 3IU8A 2Q8KA 5CE6A 2EA4A 2GG3A 3IU9A 5JHUA 4PV4A 3MATA 4U75A 2IW2A 3FMRA 2Q94A 5CDLA 1YVMA 3PKBA 3CB5A 2B3HA 3RVAA 3FMQA 2EVMA 1WN1A 2V3ZA 4S2RP 4U6EA 1R5GA 4FO8A 1KQ0A 2EVCA 4IDYA 4U71A 4IKTA 2B3KA 4U70A 4HXXA 1XGOA 2EA2A 1WL9A 5E5BA 4IF7A 4FLIA 3PKAA 3PKEA 4ZWPA 3MR1A 1XGSA 3MX6A 4FLLA 4U1BA 4U6ZA 2P98A 3PKDA 1QZYA 1WKMA 4IPAA 4U73A 4IU6A 1A16A 1XNZA 4U6WA 5JI6A 4U76A 3PKCA 2G6PA 2BHAA 3TB5A 1KQ9A 1YW7A 2NQ6A 2B3LA 4FO7A 2GU4A 2GGBA 4RZYA 3TAVA 1BN5A 1B59A 1W2MA 4S01A 4FKCA 2BWWA 2ZSGA 2BHCA 5CLSA 1O0XA 4KM3A 1JAWA 3Q6DA 1C23A 2ADUA 2OKNA 4FUKA 1C21A 1YW8A 4IECA 1C24A 1YW9A 4JUQA 4R60A 3BITA 4ZWUA 1WLRA 3S6BA 2V6CA 2V3YA 1KP0A 3CB6A 4ZWOA 2Q93A 3IU7A 1C27A 1C22A 2DFIA 3L24A 1MATA 1QXYA 1YJ3A 2BWVA 4U6CA 2BHDA 3RORA 4U69A 2GGCA 1CHMA 3CTZA 5FCFA 2GG0A 4S00A 4S2TP 4EGEA 2GG9A 5CDEA 4PNCA 1WL6A 2GG5A 1BOAA 2HOWA 4Z7MA 5JFRA 2BWYA 2GZ5A 2GG7A 2Q96A 2BWUA 2OAZA 1QXZA 2BWTA 1WY2A 1R5HA 2MATA 4OOKA 3L7GA 2P9AA 4U6JA 4A6WA 4QR8A 1B6AA 4IKUA 1WBQA 1M35A 5D6FA 5FCHA 2BHBA 4FLJA 4FLKA 1PV9A 2GTXA 2GG2A 2GU6A 3BIQA 2V3XA 3IG4A 5CNXA 2BB7A 1QXWA 4B28A 2EVOA 4RGZ1 4IKRA 3D27A 4MATA 4RZZA 2P99A 1Y1NA 2GU7A 2Q95A 2Q92A 2BN7A 1N51A 4IKSA 5CDVA 2BWXA 1R58A 5D6EA 2BH3A 2BWSA
chains in the Genus database with same CATH topology
4A6VA 5CIKA 4ZNGA 1XGMA 2GU5A 2NQ7A 1XGNA 2GA2A 2GG8A 3FM3A 1W7VA 3BIPA 3IU8A 2Q8KA 5CE6A 2EA4A 2GG3A 3IU9A 5JHUA 4PV4A 3MATA 4U75A 2IW2A 3FMRA 2Q94A 5CDLA 1YVMA 3PKBA 3CB5A 2B3HA 3RVAA 3FMQA 2EVMA 1WN1A 2V3ZA 4S2RP 4U6EA 1R5GA 4FO8A 1KQ0A 2EVCA 4IDYA 4U71A 4IKTA 2B3KA 4U70A 4HXXA 1XGOA 2EA2A 1WL9A 5E5BA 4IF7A 4FLIA 3PKAA 3PKEA 4ZWPA 3MR1A 1XGSA 3MX6A 4FLLA 4U1BA 4U6ZA 2P98A 3PKDA 1QZYA 1WKMA 4IPAA 4U73A 4IU6A 1A16A 1XNZA 4U6WA 5JI6A 4U76A 3PKCA 2G6PA 2BHAA 3TB5A 1KQ9A 1YW7A 2NQ6A 2B3LA 4FO7A 2GU4A 2GGBA 4RZYA 3TAVA 1BN5A 1B59A 1W2MA 4S01A 4FKCA 2BWWA 2ZSGA 2BHCA 5CLSA 1O0XA 4KM3A 1JAWA 3Q6DA 1C23A 2ADUA 2OKNA 4FUKA 1C21A 1YW8A 4IECA 1C24A 1YW9A 4JUQA 4R60A 3BITA 4ZWUA 1WLRA 3S6BA 2V6CA 2V3YA 1KP0A 3CB6A 4ZWOA 2Q93A 3IU7A 1C27A 1C22A 2DFIA 3L24A 1MATA 1QXYA 1YJ3A 2BWVA 4U6CA 2BHDA 3RORA 4U69A 2GGCA 1CHMA 3CTZA 5FCFA 2GG0A 4S00A 4S2TP 4EGEA 2GG9A 5CDEA 4PNCA 1WL6A 2GG5A 1BOAA 2HOWA 4Z7MA 5JFRA 2BWYA 2GZ5A 2GG7A 2Q96A 2BWUA 2OAZA 1QXZA 2BWTA 1WY2A 1R5HA 2MATA 4OOKA 3L7GA 2P9AA 4U6JA 4A6WA 4QR8A 1B6AA 4IKUA 1WBQA 1M35A 5D6FA 5FCHA 2BHBA 4FLJA 4FLKA 1PV9A 2GTXA 2GG2A 2GU6A 3BIQA 2V3XA 3IG4A 5CNXA 2BB7A 1QXWA 4B28A 2EVOA 4RGZ1 4IKRA 3D27A 4MATA 4RZZA 2P99A 1Y1NA 2GU7A 2Q95A 2Q92A 2BN7A 1N51A 4IKSA 5CDVA 2BWXA 1R58A 5D6EA 2BH3A 2BWSA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4A6V A;  5CIK A;  4ZNG A;  1XGM A;  2GU5 A;  2NQ7 A;  1XGN A;  2GA2 A;  2GG8 A;  3FM3 A;  1W7V A;  3BIP A;  3IU8 A;  2Q8K A;  5CE6 A;  2EA4 A;  2GG3 A;  3IU9 A;  5JHU A;  4PV4 A;  3MAT A;  4U75 A;  2IW2 A;  3FMR A;  2Q94 A;  5CDL A;  1YVM A;  3PKB A;  3CB5 A;  2B3H A;  3RVA A;  3FMQ A;  2EVM A;  1WN1 A;  2V3Z A;  4S2R P;  4U6E A;  1R5G A;  4FO8 A;  1KQ0 A;  2EVC A;  4IDY A;  4U71 A;  4IKT A;  2B3K A;  4U70 A;  4HXX A;  1XGO A;  2EA2 A;  1WL9 A;  5E5B A;  4IF7 A;  4FLI A;  3PKA A;  3PKE A;  4ZWP A;  3MR1 A;  1XGS A;  3MX6 A;  4FLL A;  4U1B A;  4U6Z A;  2P98 A;  3PKD A;  1QZY A;  1WKM A;  4IPA A;  4U73 A;  4IU6 A;  1A16 A;  1XNZ A;  4U6W A;  5JI6 A;  4U76 A;  3PKC A;  2G6P A;  2BHA A;  3TB5 A;  1KQ9 A;  1YW7 A;  2NQ6 A;  2B3L A;  4FO7 A;  2GU4 A;  2GGB A;  4RZY A;  3TAV A;  1BN5 A;  1B59 A;  1W2M A;  4S01 A;  4FKC A;  2BWW A;  2ZSG A;  2BHC A;  5CLS A;  1O0X A;  4KM3 A;  1JAW A;  3Q6D A;  1C23 A;  2ADU A;  2OKN A;  4FUK A;  1C21 A;  1YW8 A;  4IEC A;  1C24 A;  1YW9 A;  4JUQ A;  4R60 A;  3BIT A;  4ZWU A;  1WLR A;  3S6B A;  2V6C A;  2V3Y A;  1KP0 A;  3CB6 A;  4ZWO A;  2Q93 A;  3IU7 A;  1C27 A;  1C22 A;  2DFI A;  3L24 A;  1MAT A;  1QXY A;  1YJ3 A;  2BWV A;  4U6C A;  2BHD A;  3ROR A;  4U69 A;  2GGC A;  1CHM A;  3CTZ A;  5FCF A;  2GG0 A;  4S00 A;  4S2T P;  4EGE A;  2GG9 A;  5CDE A;  4PNC A;  1WL6 A;  2GG5 A;  1BOA A;  2HOW A;  4Z7M A;  5JFR A;  2BWY A;  2GZ5 A;  2GG7 A;  2Q96 A;  2BWU A;  2OAZ A;  1QXZ A;  2BWT A;  1WY2 A;  1R5H A;  2MAT A;  4OOK A;  3L7G A;  2P9A A;  4U6J A;  4A6W A;  4QR8 A;  1B6A A;  4IKU A;  1WBQ A;  1M35 A;  5D6F A;  5FCH A;  2BHB A;  4FLJ A;  4FLK A;  1PV9 A;  2GTX A;  2GG2 A;  2GU6 A;  3BIQ A;  2V3X A;  3IG4 A;  5CNX A;  2BB7 A;  1QXW A;  4B28 A;  2EVO A;  4RGZ 1;  4IKR A;  3D27 A;  4MAT A;  4RZZ A;  2P99 A;  1Y1N A;  2GU7 A;  2Q95 A;  2Q92 A;  2BN7 A;  1N51 A;  4IKS A;  5CDV A;  2BWX A;  1R58 A;  5D6E A;  2BH3 A;  2BWS A; 
#chains in the Genus database with same CATH topology
 4A6V A;  5CIK A;  4ZNG A;  1XGM A;  2GU5 A;  2NQ7 A;  1XGN A;  2GA2 A;  2GG8 A;  3FM3 A;  1W7V A;  3BIP A;  3IU8 A;  2Q8K A;  5CE6 A;  2EA4 A;  2GG3 A;  3IU9 A;  5JHU A;  4PV4 A;  3MAT A;  4U75 A;  2IW2 A;  3FMR A;  2Q94 A;  5CDL A;  1YVM A;  3PKB A;  3CB5 A;  2B3H A;  3RVA A;  3FMQ A;  2EVM A;  1WN1 A;  2V3Z A;  4S2R P;  4U6E A;  1R5G A;  4FO8 A;  1KQ0 A;  2EVC A;  4IDY A;  4U71 A;  4IKT A;  2B3K A;  4U70 A;  4HXX A;  1XGO A;  2EA2 A;  1WL9 A;  5E5B A;  4IF7 A;  4FLI A;  3PKA A;  3PKE A;  4ZWP A;  3MR1 A;  1XGS A;  3MX6 A;  4FLL A;  4U1B A;  4U6Z A;  2P98 A;  3PKD A;  1QZY A;  1WKM A;  4IPA A;  4U73 A;  4IU6 A;  1A16 A;  1XNZ A;  4U6W A;  5JI6 A;  4U76 A;  3PKC A;  2G6P A;  2BHA A;  3TB5 A;  1KQ9 A;  1YW7 A;  2NQ6 A;  2B3L A;  4FO7 A;  2GU4 A;  2GGB A;  4RZY A;  3TAV A;  1BN5 A;  1B59 A;  1W2M A;  4S01 A;  4FKC A;  2BWW A;  2ZSG A;  2BHC A;  5CLS A;  1O0X A;  4KM3 A;  1JAW A;  3Q6D A;  1C23 A;  2ADU A;  2OKN A;  4FUK A;  1C21 A;  1YW8 A;  4IEC A;  1C24 A;  1YW9 A;  4JUQ A;  4R60 A;  3BIT A;  4ZWU A;  1WLR A;  3S6B A;  2V6C A;  2V3Y A;  1KP0 A;  3CB6 A;  4ZWO A;  2Q93 A;  3IU7 A;  1C27 A;  1C22 A;  2DFI A;  3L24 A;  1MAT A;  1QXY A;  1YJ3 A;  2BWV A;  4U6C A;  2BHD A;  3ROR A;  4U69 A;  2GGC A;  1CHM A;  3CTZ A;  5FCF A;  2GG0 A;  4S00 A;  4S2T P;  4EGE A;  2GG9 A;  5CDE A;  4PNC A;  1WL6 A;  2GG5 A;  1BOA A;  2HOW A;  4Z7M A;  5JFR A;  2BWY A;  2GZ5 A;  2GG7 A;  2Q96 A;  2BWU A;  2OAZ A;  1QXZ A;  2BWT A;  1WY2 A;  1R5H A;  2MAT A;  4OOK A;  3L7G A;  2P9A A;  4U6J A;  4A6W A;  4QR8 A;  1B6A A;  4IKU A;  1WBQ A;  1M35 A;  5D6F A;  5FCH A;  2BHB A;  4FLJ A;  4FLK A;  1PV9 A;  2GTX A;  2GG2 A;  2GU6 A;  3BIQ A;  2V3X A;  3IG4 A;  5CNX A;  2BB7 A;  1QXW A;  4B28 A;  2EVO A;  4RGZ 1;  4IKR A;  3D27 A;  4MAT A;  4RZZ A;  2P99 A;  1Y1N A;  2GU7 A;  2Q95 A;  2Q92 A;  2BN7 A;  1N51 A;  4IKS A;  5CDV A;  2BWX A;  1R58 A;  5D6E A;  2BH3 A;  2BWS A; 
#chains in the Genus database with same CATH homology
 4A6V A;  5CIK A;  4ZNG A;  1XGM A;  2GU5 A;  2NQ7 A;  1XGN A;  2GA2 A;  2GG8 A;  3FM3 A;  1W7V A;  3BIP A;  3IU8 A;  2Q8K A;  5CE6 A;  2EA4 A;  2GG3 A;  3IU9 A;  5JHU A;  4PV4 A;  3MAT A;  4U75 A;  2IW2 A;  3FMR A;  2Q94 A;  5CDL A;  1YVM A;  3PKB A;  3CB5 A;  2B3H A;  3RVA A;  3FMQ A;  2EVM A;  1WN1 A;  2V3Z A;  4S2R P;  4U6E A;  1R5G A;  4FO8 A;  1KQ0 A;  2EVC A;  4IDY A;  4U71 A;  4IKT A;  2B3K A;  4U70 A;  4HXX A;  1XGO A;  2EA2 A;  1WL9 A;  5E5B A;  4IF7 A;  4FLI A;  3PKA A;  3PKE A;  4ZWP A;  3MR1 A;  1XGS A;  3MX6 A;  4FLL A;  4U1B A;  4U6Z A;  2P98 A;  3PKD A;  1QZY A;  1WKM A;  4IPA A;  4U73 A;  4IU6 A;  1A16 A;  1XNZ A;  4U6W A;  5JI6 A;  4U76 A;  3PKC A;  2G6P A;  2BHA A;  3TB5 A;  1KQ9 A;  1YW7 A;  2NQ6 A;  2B3L A;  4FO7 A;  2GU4 A;  2GGB A;  4RZY A;  3TAV A;  1BN5 A;  1B59 A;  1W2M A;  4S01 A;  4FKC A;  2BWW A;  2ZSG A;  2BHC A;  5CLS A;  1O0X A;  4KM3 A;  1JAW A;  3Q6D A;  1C23 A;  2ADU A;  2OKN A;  4FUK A;  1C21 A;  1YW8 A;  4IEC A;  1C24 A;  1YW9 A;  4JUQ A;  4R60 A;  3BIT A;  4ZWU A;  1WLR A;  3S6B A;  2V6C A;  2V3Y A;  1KP0 A;  3CB6 A;  4ZWO A;  2Q93 A;  3IU7 A;  1C27 A;  1C22 A;  2DFI A;  3L24 A;  1MAT A;  1QXY A;  1YJ3 A;  2BWV A;  4U6C A;  2BHD A;  3ROR A;  4U69 A;  2GGC A;  1CHM A;  3CTZ A;  5FCF A;  2GG0 A;  4S00 A;  4S2T P;  4EGE A;  2GG9 A;  5CDE A;  4PNC A;  1WL6 A;  2GG5 A;  1BOA A;  2HOW A;  4Z7M A;  5JFR A;  2BWY A;  2GZ5 A;  2GG7 A;  2Q96 A;  2BWU A;  2OAZ A;  1QXZ A;  2BWT A;  1WY2 A;  1R5H A;  2MAT A;  4OOK A;  3L7G A;  2P9A A;  4U6J A;  4A6W A;  4QR8 A;  1B6A A;  4IKU A;  1WBQ A;  1M35 A;  5D6F A;  5FCH A;  2BHB A;  4FLJ A;  4FLK A;  1PV9 A;  2GTX A;  2GG2 A;  2GU6 A;  3BIQ A;  2V3X A;  3IG4 A;  5CNX A;  2BB7 A;  1QXW A;  4B28 A;  2EVO A;  4RGZ 1;  4IKR A;  3D27 A;  4MAT A;  4RZZ A;  2P99 A;  1Y1N A;  2GU7 A;  2Q95 A;  2Q92 A;  2BN7 A;  1N51 A;  4IKS A;  5CDV A;  2BWX A;  1R58 A;  5D6E A;  2BH3 A;  2BWS A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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