4U6WA

Hsmetap (f220m) in complex with 1-amino-2-propylpentyl]phosphonic acid
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6wA00
2V6CA 2Q94A 4U75A 2OAZA 1C21A 2IW2A 3TAVA 2Q92A 4JUQA 2GGBA 2Q93A 2GU6A 4IDYA 3PKDA 1C27A 1C22A 2BH3A 4PV4A 1O0XA 4A6VA 1R5GA 1WL6A 3BIQA 1YW8A 3IG4A 5E5BA 2ADUA 2B3HA 2GU7A 3MATA 4IKRA 4FLLA 1WLRA 1R58A 4RZYA 3PKCA 2P99A 1XNZA 4U69A 2GG7A 4U6ZA 2EVCA 4FKCA 4B28A 2P9AA 5CDEA 1WY2A 4RGZ1 1PV9A 2BWVA 3MR1A 2NQ6A 1QXZA 1WL9A 2GU5A 3L7GA 1XGSA 4FO8A 2BN7A 2GA2A 1XGNA 2NQ7A 2EVOA 3Q6DA 4U1BA 4MATA 1YW7A 2MATA 1B59A 3BIPA 2BWWA 3FMQA 2BWSA 4A6WA 1N51A 1JAWA 3PKAA 2BHBA 1KQ0A 2GZ5A 4S2TP 4U6EA 3PKEA 1QZYA 4U70A 1XGOA 1B6AA 1BOAA 3TB5A 3FMRA 4FLIA 5CDLA 2GG0A 2HOWA 4HXXA 4U76A 3RORA 1CHMA 3CB6A 4FLJA 2BHCA 1Y1NA 1WKMA 5CDVA 5D6EA 3PKBA 2BWYA 2G6PA 4RZZA 4U6JA 4QR8A 4IPAA 5FCHA 2B3LA 3FM3A 4U6WA 1YJ3A 4R60A 2EA2A 4IKSA 5CIKA 1QXYA 1WBQA 3IU7A 4IECA 5CLSA 1WN1A 2B3KA 5JHUA 5JI6A 4PNCA 4KM3A 3CB5A 4EGEA 2GGCA 2P98A 1KQ9A 2BWXA 1YVMA 2EA4A 2GG8A 2GTXA 4ZNGA 1BN5A 5CNXA 3RVAA 2V3ZA 5JFRA 4U71A 1C24A 3BITA 2GG2A 3D27A 1QXWA 4IKTA 5D6FA 4IKUA 2Q8KA 4S00A 3IU8A 4ZWOA 2V3XA 3IU9A 4IF7A 1YW9A 2BHDA 2GG3A 2EVMA 4S2RP 3CTZA 4FO7A 2Q95A 2V3YA 4S01A 2OKNA 5FCFA 2BWUA 4FLKA 1A16A 4ZWUA 2GG9A 1M35A 5CE6A 1MATA 3L24A 2BHAA 1KP0A 1W2MA 1C23A 1R5HA 2BWTA 4U73A 4U6CA 2GG5A 2ZSGA 4FUKA 1XGMA 2Q96A 4Z7MA 3MX6A 2BB7A 3S6BA 4OOKA 2DFIA 4IU6A 2GU4A 1W7VA 4ZWPA
chains in the Genus database with same CATH superfamily
2V6CA 2Q94A 4U75A 2OAZA 1C21A 2IW2A 3TAVA 2Q92A 4JUQA 2GGBA 2Q93A 2GU6A 4IDYA 3PKDA 1C27A 1C22A 2BH3A 4PV4A 1O0XA 4A6VA 1R5GA 1WL6A 3BIQA 1YW8A 3IG4A 5E5BA 2ADUA 2B3HA 2GU7A 3MATA 4IKRA 4FLLA 1WLRA 1R58A 4RZYA 3PKCA 2P99A 1XNZA 4U69A 2GG7A 4U6ZA 2EVCA 4FKCA 4B28A 2P9AA 5CDEA 1WY2A 4RGZ1 1PV9A 2BWVA 3MR1A 2NQ6A 1QXZA 1WL9A 2GU5A 3L7GA 1XGSA 4FO8A 2BN7A 2GA2A 1XGNA 2NQ7A 2EVOA 3Q6DA 4U1BA 4MATA 1YW7A 2MATA 1B59A 3BIPA 2BWWA 3FMQA 2BWSA 4A6WA 1N51A 1JAWA 3PKAA 2BHBA 1KQ0A 2GZ5A 4S2TP 4U6EA 3PKEA 1QZYA 4U70A 1XGOA 1B6AA 1BOAA 3TB5A 3FMRA 4FLIA 5CDLA 2GG0A 2HOWA 4HXXA 4U76A 3RORA 1CHMA 3CB6A 4FLJA 2BHCA 1Y1NA 1WKMA 5CDVA 5D6EA 3PKBA 2BWYA 2G6PA 4RZZA 4U6JA 4QR8A 4IPAA 5FCHA 2B3LA 3FM3A 4U6WA 1YJ3A 4R60A 2EA2A 4IKSA 5CIKA 1QXYA 1WBQA 3IU7A 4IECA 5CLSA 1WN1A 2B3KA 5JHUA 5JI6A 4PNCA 4KM3A 3CB5A 4EGEA 2GGCA 2P98A 1KQ9A 2BWXA 1YVMA 2EA4A 2GG8A 2GTXA 4ZNGA 1BN5A 5CNXA 3RVAA 2V3ZA 5JFRA 4U71A 1C24A 3BITA 2GG2A 3D27A 1QXWA 4IKTA 5D6FA 4IKUA 2Q8KA 4S00A 3IU8A 4ZWOA 2V3XA 3IU9A 4IF7A 1YW9A 2BHDA 2GG3A 2EVMA 4S2RP 3CTZA 4FO7A 2Q95A 2V3YA 4S01A 2OKNA 5FCFA 2BWUA 4FLKA 1A16A 4ZWUA 2GG9A 1M35A 5CE6A 1MATA 3L24A 2BHAA 1KP0A 1W2MA 1C23A 1R5HA 2BWTA 4U73A 4U6CA 2GG5A 2ZSGA 4FUKA 1XGMA 2Q96A 4Z7MA 3MX6A 2BB7A 3S6BA 4OOKA 2DFIA 4IU6A 2GU4A 1W7VA 4ZWPA
chains in the Genus database with same CATH topology
2V6CA 2Q94A 4U75A 2OAZA 1C21A 2IW2A 3TAVA 2Q92A 4JUQA 2GGBA 2Q93A 2GU6A 4IDYA 3PKDA 1C27A 1C22A 2BH3A 4PV4A 1O0XA 4A6VA 1R5GA 1WL6A 3BIQA 1YW8A 3IG4A 5E5BA 2ADUA 2B3HA 2GU7A 3MATA 4IKRA 4FLLA 1WLRA 1R58A 4RZYA 3PKCA 2P99A 1XNZA 4U69A 2GG7A 4U6ZA 2EVCA 4FKCA 4B28A 2P9AA 5CDEA 1WY2A 4RGZ1 1PV9A 2BWVA 3MR1A 2NQ6A 1QXZA 1WL9A 2GU5A 3L7GA 1XGSA 4FO8A 2BN7A 2GA2A 1XGNA 2NQ7A 2EVOA 3Q6DA 4U1BA 4MATA 1YW7A 2MATA 1B59A 3BIPA 2BWWA 3FMQA 2BWSA 4A6WA 1N51A 1JAWA 3PKAA 2BHBA 1KQ0A 2GZ5A 4S2TP 4U6EA 3PKEA 1QZYA 4U70A 1XGOA 1B6AA 1BOAA 3TB5A 3FMRA 4FLIA 5CDLA 2GG0A 2HOWA 4HXXA 4U76A 3RORA 1CHMA 3CB6A 4FLJA 2BHCA 1Y1NA 1WKMA 5CDVA 5D6EA 3PKBA 2BWYA 2G6PA 4RZZA 4U6JA 4QR8A 4IPAA 5FCHA 2B3LA 3FM3A 4U6WA 1YJ3A 4R60A 2EA2A 4IKSA 5CIKA 1QXYA 1WBQA 3IU7A 4IECA 5CLSA 1WN1A 2B3KA 5JHUA 5JI6A 4PNCA 4KM3A 3CB5A 4EGEA 2GGCA 2P98A 1KQ9A 2BWXA 1YVMA 2EA4A 2GG8A 2GTXA 4ZNGA 1BN5A 5CNXA 3RVAA 2V3ZA 5JFRA 4U71A 1C24A 3BITA 2GG2A 3D27A 1QXWA 4IKTA 5D6FA 4IKUA 2Q8KA 4S00A 3IU8A 4ZWOA 2V3XA 3IU9A 4IF7A 1YW9A 2BHDA 2GG3A 2EVMA 4S2RP 3CTZA 4FO7A 2Q95A 2V3YA 4S01A 2OKNA 5FCFA 2BWUA 4FLKA 1A16A 4ZWUA 2GG9A 1M35A 5CE6A 1MATA 3L24A 2BHAA 1KP0A 1W2MA 1C23A 1R5HA 2BWTA 4U73A 4U6CA 2GG5A 2ZSGA 4FUKA 1XGMA 2Q96A 4Z7MA 3MX6A 2BB7A 3S6BA 4OOKA 2DFIA 4IU6A 2GU4A 1W7VA 4ZWPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V6C A;  2Q94 A;  4U75 A;  2OAZ A;  1C21 A;  2IW2 A;  3TAV A;  2Q92 A;  4JUQ A;  2GGB A;  2Q93 A;  2GU6 A;  4IDY A;  3PKD A;  1C27 A;  1C22 A;  2BH3 A;  4PV4 A;  1O0X A;  4A6V A;  1R5G A;  1WL6 A;  3BIQ A;  1YW8 A;  3IG4 A;  5E5B A;  2ADU A;  2B3H A;  2GU7 A;  3MAT A;  4IKR A;  4FLL A;  1WLR A;  1R58 A;  4RZY A;  3PKC A;  2P99 A;  1XNZ A;  4U69 A;  2GG7 A;  4U6Z A;  2EVC A;  4FKC A;  4B28 A;  2P9A A;  5CDE A;  1WY2 A;  4RGZ 1;  1PV9 A;  2BWV A;  3MR1 A;  2NQ6 A;  1QXZ A;  1WL9 A;  2GU5 A;  3L7G A;  1XGS A;  4FO8 A;  2BN7 A;  2GA2 A;  1XGN A;  2NQ7 A;  2EVO A;  3Q6D A;  4U1B A;  4MAT A;  1YW7 A;  2MAT A;  1B59 A;  3BIP A;  2BWW A;  3FMQ A;  2BWS A;  4A6W A;  1N51 A;  1JAW A;  3PKA A;  2BHB A;  1KQ0 A;  2GZ5 A;  4S2T P;  4U6E A;  3PKE A;  1QZY A;  4U70 A;  1XGO A;  1B6A A;  1BOA A;  3TB5 A;  3FMR A;  4FLI A;  5CDL A;  2GG0 A;  2HOW A;  4HXX A;  4U76 A;  3ROR A;  1CHM A;  3CB6 A;  4FLJ A;  2BHC A;  1Y1N A;  1WKM A;  5CDV A;  5D6E A;  3PKB A;  2BWY A;  2G6P A;  4RZZ A;  4U6J A;  4QR8 A;  4IPA A;  5FCH A;  2B3L A;  3FM3 A;  4U6W A;  1YJ3 A;  4R60 A;  2EA2 A;  4IKS A;  5CIK A;  1QXY A;  1WBQ A;  3IU7 A;  4IEC A;  5CLS A;  1WN1 A;  2B3K A;  5JHU A;  5JI6 A;  4PNC A;  4KM3 A;  3CB5 A;  4EGE A;  2GGC A;  2P98 A;  1KQ9 A;  2BWX A;  1YVM A;  2EA4 A;  2GG8 A;  2GTX A;  4ZNG A;  1BN5 A;  5CNX A;  3RVA A;  2V3Z A;  5JFR A;  4U71 A;  1C24 A;  3BIT A;  2GG2 A;  3D27 A;  1QXW A;  4IKT A;  5D6F A;  4IKU A;  2Q8K A;  4S00 A;  3IU8 A;  4ZWO A;  2V3X A;  3IU9 A;  4IF7 A;  1YW9 A;  2BHD A;  2GG3 A;  2EVM A;  4S2R P;  3CTZ A;  4FO7 A;  2Q95 A;  2V3Y A;  4S01 A;  2OKN A;  5FCF A;  2BWU A;  4FLK A;  1A16 A;  4ZWU A;  2GG9 A;  1M35 A;  5CE6 A;  1MAT A;  3L24 A;  2BHA A;  1KP0 A;  1W2M A;  1C23 A;  1R5H A;  2BWT A;  4U73 A;  4U6C A;  2GG5 A;  2ZSG A;  4FUK A;  1XGM A;  2Q96 A;  4Z7M A;  3MX6 A;  2BB7 A;  3S6B A;  4OOK A;  2DFI A;  4IU6 A;  2GU4 A;  1W7V A;  4ZWP A; 
#chains in the Genus database with same CATH topology
 2V6C A;  2Q94 A;  4U75 A;  2OAZ A;  1C21 A;  2IW2 A;  3TAV A;  2Q92 A;  4JUQ A;  2GGB A;  2Q93 A;  2GU6 A;  4IDY A;  3PKD A;  1C27 A;  1C22 A;  2BH3 A;  4PV4 A;  1O0X A;  4A6V A;  1R5G A;  1WL6 A;  3BIQ A;  1YW8 A;  3IG4 A;  5E5B A;  2ADU A;  2B3H A;  2GU7 A;  3MAT A;  4IKR A;  4FLL A;  1WLR A;  1R58 A;  4RZY A;  3PKC A;  2P99 A;  1XNZ A;  4U69 A;  2GG7 A;  4U6Z A;  2EVC A;  4FKC A;  4B28 A;  2P9A A;  5CDE A;  1WY2 A;  4RGZ 1;  1PV9 A;  2BWV A;  3MR1 A;  2NQ6 A;  1QXZ A;  1WL9 A;  2GU5 A;  3L7G A;  1XGS A;  4FO8 A;  2BN7 A;  2GA2 A;  1XGN A;  2NQ7 A;  2EVO A;  3Q6D A;  4U1B A;  4MAT A;  1YW7 A;  2MAT A;  1B59 A;  3BIP A;  2BWW A;  3FMQ A;  2BWS A;  4A6W A;  1N51 A;  1JAW A;  3PKA A;  2BHB A;  1KQ0 A;  2GZ5 A;  4S2T P;  4U6E A;  3PKE A;  1QZY A;  4U70 A;  1XGO A;  1B6A A;  1BOA A;  3TB5 A;  3FMR A;  4FLI A;  5CDL A;  2GG0 A;  2HOW A;  4HXX A;  4U76 A;  3ROR A;  1CHM A;  3CB6 A;  4FLJ A;  2BHC A;  1Y1N A;  1WKM A;  5CDV A;  5D6E A;  3PKB A;  2BWY A;  2G6P A;  4RZZ A;  4U6J A;  4QR8 A;  4IPA A;  5FCH A;  2B3L A;  3FM3 A;  4U6W A;  1YJ3 A;  4R60 A;  2EA2 A;  4IKS A;  5CIK A;  1QXY A;  1WBQ A;  3IU7 A;  4IEC A;  5CLS A;  1WN1 A;  2B3K A;  5JHU A;  5JI6 A;  4PNC A;  4KM3 A;  3CB5 A;  4EGE A;  2GGC A;  2P98 A;  1KQ9 A;  2BWX A;  1YVM A;  2EA4 A;  2GG8 A;  2GTX A;  4ZNG A;  1BN5 A;  5CNX A;  3RVA A;  2V3Z A;  5JFR A;  4U71 A;  1C24 A;  3BIT A;  2GG2 A;  3D27 A;  1QXW A;  4IKT A;  5D6F A;  4IKU A;  2Q8K A;  4S00 A;  3IU8 A;  4ZWO A;  2V3X A;  3IU9 A;  4IF7 A;  1YW9 A;  2BHD A;  2GG3 A;  2EVM A;  4S2R P;  3CTZ A;  4FO7 A;  2Q95 A;  2V3Y A;  4S01 A;  2OKN A;  5FCF A;  2BWU A;  4FLK A;  1A16 A;  4ZWU A;  2GG9 A;  1M35 A;  5CE6 A;  1MAT A;  3L24 A;  2BHA A;  1KP0 A;  1W2M A;  1C23 A;  1R5H A;  2BWT A;  4U73 A;  4U6C A;  2GG5 A;  2ZSG A;  4FUK A;  1XGM A;  2Q96 A;  4Z7M A;  3MX6 A;  2BB7 A;  3S6B A;  4OOK A;  2DFI A;  4IU6 A;  2GU4 A;  1W7V A;  4ZWP A; 
#chains in the Genus database with same CATH homology
 2V6C A;  2Q94 A;  4U75 A;  2OAZ A;  1C21 A;  2IW2 A;  3TAV A;  2Q92 A;  4JUQ A;  2GGB A;  2Q93 A;  2GU6 A;  4IDY A;  3PKD A;  1C27 A;  1C22 A;  2BH3 A;  4PV4 A;  1O0X A;  4A6V A;  1R5G A;  1WL6 A;  3BIQ A;  1YW8 A;  3IG4 A;  5E5B A;  2ADU A;  2B3H A;  2GU7 A;  3MAT A;  4IKR A;  4FLL A;  1WLR A;  1R58 A;  4RZY A;  3PKC A;  2P99 A;  1XNZ A;  4U69 A;  2GG7 A;  4U6Z A;  2EVC A;  4FKC A;  4B28 A;  2P9A A;  5CDE A;  1WY2 A;  4RGZ 1;  1PV9 A;  2BWV A;  3MR1 A;  2NQ6 A;  1QXZ A;  1WL9 A;  2GU5 A;  3L7G A;  1XGS A;  4FO8 A;  2BN7 A;  2GA2 A;  1XGN A;  2NQ7 A;  2EVO A;  3Q6D A;  4U1B A;  4MAT A;  1YW7 A;  2MAT A;  1B59 A;  3BIP A;  2BWW A;  3FMQ A;  2BWS A;  4A6W A;  1N51 A;  1JAW A;  3PKA A;  2BHB A;  1KQ0 A;  2GZ5 A;  4S2T P;  4U6E A;  3PKE A;  1QZY A;  4U70 A;  1XGO A;  1B6A A;  1BOA A;  3TB5 A;  3FMR A;  4FLI A;  5CDL A;  2GG0 A;  2HOW A;  4HXX A;  4U76 A;  3ROR A;  1CHM A;  3CB6 A;  4FLJ A;  2BHC A;  1Y1N A;  1WKM A;  5CDV A;  5D6E A;  3PKB A;  2BWY A;  2G6P A;  4RZZ A;  4U6J A;  4QR8 A;  4IPA A;  5FCH A;  2B3L A;  3FM3 A;  4U6W A;  1YJ3 A;  4R60 A;  2EA2 A;  4IKS A;  5CIK A;  1QXY A;  1WBQ A;  3IU7 A;  4IEC A;  5CLS A;  1WN1 A;  2B3K A;  5JHU A;  5JI6 A;  4PNC A;  4KM3 A;  3CB5 A;  4EGE A;  2GGC A;  2P98 A;  1KQ9 A;  2BWX A;  1YVM A;  2EA4 A;  2GG8 A;  2GTX A;  4ZNG A;  1BN5 A;  5CNX A;  3RVA A;  2V3Z A;  5JFR A;  4U71 A;  1C24 A;  3BIT A;  2GG2 A;  3D27 A;  1QXW A;  4IKT A;  5D6F A;  4IKU A;  2Q8K A;  4S00 A;  3IU8 A;  4ZWO A;  2V3X A;  3IU9 A;  4IF7 A;  1YW9 A;  2BHD A;  2GG3 A;  2EVM A;  4S2R P;  3CTZ A;  4FO7 A;  2Q95 A;  2V3Y A;  4S01 A;  2OKN A;  5FCF A;  2BWU A;  4FLK A;  1A16 A;  4ZWU A;  2GG9 A;  1M35 A;  5CE6 A;  1MAT A;  3L24 A;  2BHA A;  1KP0 A;  1W2M A;  1C23 A;  1R5H A;  2BWT A;  4U73 A;  4U6C A;  2GG5 A;  2ZSG A;  4FUK A;  1XGM A;  2Q96 A;  4Z7M A;  3MX6 A;  2BB7 A;  3S6B A;  4OOK A;  2DFI A;  4IU6 A;  2GU4 A;  1W7V A;  4ZWP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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