4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
5JI6A 2EA2A 3TAVA 4S01A 2BH3A 2ZSGA 2P9AA 1QXYA 3PKEA 4FLKA 4U76A 4U6JA 3FM3A 2V3ZA 3BIPA 2BHCA 1W7VA 3PKCA 1QZYA 4Z7MA 2V3YA 2V3XA 1XGNA 2Q95A 1C27A 3RORA 2EA4A 1CHMA 2BN7A 1XGSA 4FO7A 4ZWUA 4U1BA 2GTXA 1JAWA 5FCHA 2BWVA 5CDVA 2BHBA 2BWXA 4RZYA 2Q93A 5D6EA 2GG0A 5JHUA 1WKMA 2OKNA 3BITA 4PNCA 4U6WA 2V6CA 5FCFA 1XGOA 4U6CA 2GG5A 3Q6DA 4U70A 1B59A 4FLJA 1PV9A 2G6PA 2MATA 4IU6A 1WL6A 1R58A 5E5BA 3D27A 1WBQA 2GZ5A 1A16A 4IF7A 5CLSA 1QXWA 2GGBA 4HXXA 4FO8A 1KQ9A 2P98A 4FLLA 2HOWA 4ZWOA 1YW8A 2GU5A 4JUQA 3IU8A 2NQ7A 2GU7A 3MATA 4U69A 5CIKA 4R60A 2GU6A 3L24A 4OOKA 4U71A 1XNZA 4IPAA 4IKSA 4RGZ1 4KM3A 2Q94A 1C21A 4A6WA 2GGCA 3FMRA 2BWSA 3IU9A 2GG9A 4IKUA 2B3KA 1B6AA 2Q96A 2Q92A 3RVAA 2BHAA 1KQ0A 4B28A 4EGEA 1MATA 5CDEA 3BIQA 1BOAA 1C24A 1N51A 1O0XA 3FMQA 2EVMA 4S00A 1WY2A 3PKBA 4S2RP 4A6VA 2NQ6A 1XGMA 3CTZA 2EVOA 4U73A 4S2TP 5D6FA 2EVCA 4U6ZA 3MR1A 4IECA 1Y1NA 3IU7A 1M35A 2BB7A 2GU4A 3TB5A 4FKCA 2DFIA 4RZZA 1W2MA 3CB5A 3CB6A 2ADUA 3IG4A 1YJ3A 3MX6A 2B3HA 5CE6A 1WLRA 1QXZA 1C22A 4FLIA 3S6BA 4U6EA 3PKDA 4FUKA 1BN5A 2BWTA 1WL9A 4MATA 4U75A 2B3LA 5JFRA 3PKAA 1YW9A 1YW7A 2OAZA 2BWUA 2GG3A 2GA2A 1WN1A 4IKTA 4ZNGA 4ZWPA 1KP0A 2BWYA 5CDLA 5CNXA 4QR8A 2BHDA 1YVMA 2P99A 2GG8A 2IW2A 1R5HA 2GG7A 4IKRA 1R5GA 2BWWA 4IDYA 1C23A 2Q8KA 4PV4A 2GG2A 3L7GA
chains in the Genus database with same CATH superfamily
5JI6A 2EA2A 3TAVA 4S01A 2BH3A 2ZSGA 2P9AA 1QXYA 3PKEA 4FLKA 4U76A 4U6JA 3FM3A 2V3ZA 3BIPA 2BHCA 1W7VA 3PKCA 1QZYA 4Z7MA 2V3YA 2V3XA 1XGNA 2Q95A 1C27A 3RORA 2EA4A 1CHMA 2BN7A 1XGSA 4FO7A 4ZWUA 4U1BA 2GTXA 1JAWA 5FCHA 2BWVA 5CDVA 2BHBA 2BWXA 4RZYA 2Q93A 5D6EA 2GG0A 5JHUA 1WKMA 2OKNA 3BITA 4PNCA 4U6WA 2V6CA 5FCFA 1XGOA 4U6CA 2GG5A 3Q6DA 4U70A 1B59A 4FLJA 1PV9A 2G6PA 2MATA 4IU6A 1WL6A 1R58A 5E5BA 3D27A 1WBQA 2GZ5A 1A16A 4IF7A 5CLSA 1QXWA 2GGBA 4HXXA 4FO8A 1KQ9A 2P98A 4FLLA 2HOWA 4ZWOA 1YW8A 2GU5A 4JUQA 3IU8A 2NQ7A 2GU7A 3MATA 4U69A 5CIKA 4R60A 2GU6A 3L24A 4OOKA 4U71A 1XNZA 4IPAA 4IKSA 4RGZ1 4KM3A 2Q94A 1C21A 4A6WA 2GGCA 3FMRA 2BWSA 3IU9A 2GG9A 4IKUA 2B3KA 1B6AA 2Q96A 2Q92A 3RVAA 2BHAA 1KQ0A 4B28A 4EGEA 1MATA 5CDEA 3BIQA 1BOAA 1C24A 1N51A 1O0XA 3FMQA 2EVMA 4S00A 1WY2A 3PKBA 4S2RP 4A6VA 2NQ6A 1XGMA 3CTZA 2EVOA 4U73A 4S2TP 5D6FA 2EVCA 4U6ZA 3MR1A 4IECA 1Y1NA 3IU7A 1M35A 2BB7A 2GU4A 3TB5A 4FKCA 2DFIA 4RZZA 1W2MA 3CB5A 3CB6A 2ADUA 3IG4A 1YJ3A 3MX6A 2B3HA 5CE6A 1WLRA 1QXZA 1C22A 4FLIA 3S6BA 4U6EA 3PKDA 4FUKA 1BN5A 2BWTA 1WL9A 4MATA 4U75A 2B3LA 5JFRA 3PKAA 1YW9A 1YW7A 2OAZA 2BWUA 2GG3A 2GA2A 1WN1A 4IKTA 4ZNGA 4ZWPA 1KP0A 2BWYA 5CDLA 5CNXA 4QR8A 2BHDA 1YVMA 2P99A 2GG8A 2IW2A 1R5HA 2GG7A 4IKRA 1R5GA 2BWWA 4IDYA 1C23A 2Q8KA 4PV4A 2GG2A 3L7GA
chains in the Genus database with same CATH topology
5JI6A 2EA2A 3TAVA 4S01A 2BH3A 2ZSGA 2P9AA 1QXYA 3PKEA 4FLKA 4U76A 4U6JA 3FM3A 2V3ZA 3BIPA 2BHCA 1W7VA 3PKCA 1QZYA 4Z7MA 2V3YA 2V3XA 1XGNA 2Q95A 1C27A 3RORA 2EA4A 1CHMA 2BN7A 1XGSA 4FO7A 4ZWUA 4U1BA 2GTXA 1JAWA 5FCHA 2BWVA 5CDVA 2BHBA 2BWXA 4RZYA 2Q93A 5D6EA 2GG0A 5JHUA 1WKMA 2OKNA 3BITA 4PNCA 4U6WA 2V6CA 5FCFA 1XGOA 4U6CA 2GG5A 3Q6DA 4U70A 1B59A 4FLJA 1PV9A 2G6PA 2MATA 4IU6A 1WL6A 1R58A 5E5BA 3D27A 1WBQA 2GZ5A 1A16A 4IF7A 5CLSA 1QXWA 2GGBA 4HXXA 4FO8A 1KQ9A 2P98A 4FLLA 2HOWA 4ZWOA 1YW8A 2GU5A 4JUQA 3IU8A 2NQ7A 2GU7A 3MATA 4U69A 5CIKA 4R60A 2GU6A 3L24A 4OOKA 4U71A 1XNZA 4IPAA 4IKSA 4RGZ1 4KM3A 2Q94A 1C21A 4A6WA 2GGCA 3FMRA 2BWSA 3IU9A 2GG9A 4IKUA 2B3KA 1B6AA 2Q96A 2Q92A 3RVAA 2BHAA 1KQ0A 4B28A 4EGEA 1MATA 5CDEA 3BIQA 1BOAA 1C24A 1N51A 1O0XA 3FMQA 2EVMA 4S00A 1WY2A 3PKBA 4S2RP 4A6VA 2NQ6A 1XGMA 3CTZA 2EVOA 4U73A 4S2TP 5D6FA 2EVCA 4U6ZA 3MR1A 4IECA 1Y1NA 3IU7A 1M35A 2BB7A 2GU4A 3TB5A 4FKCA 2DFIA 4RZZA 1W2MA 3CB5A 3CB6A 2ADUA 3IG4A 1YJ3A 3MX6A 2B3HA 5CE6A 1WLRA 1QXZA 1C22A 4FLIA 3S6BA 4U6EA 3PKDA 4FUKA 1BN5A 2BWTA 1WL9A 4MATA 4U75A 2B3LA 5JFRA 3PKAA 1YW9A 1YW7A 2OAZA 2BWUA 2GG3A 2GA2A 1WN1A 4IKTA 4ZNGA 4ZWPA 1KP0A 2BWYA 5CDLA 5CNXA 4QR8A 2BHDA 1YVMA 2P99A 2GG8A 2IW2A 1R5HA 2GG7A 4IKRA 1R5GA 2BWWA 4IDYA 1C23A 2Q8KA 4PV4A 2GG2A 3L7GA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5JI6 A;  2EA2 A;  3TAV A;  4S01 A;  2BH3 A;  2ZSG A;  2P9A A;  1QXY A;  3PKE A;  4FLK A;  4U76 A;  4U6J A;  3FM3 A;  2V3Z A;  3BIP A;  2BHC A;  1W7V A;  3PKC A;  1QZY A;  4Z7M A;  2V3Y A;  2V3X A;  1XGN A;  2Q95 A;  1C27 A;  3ROR A;  2EA4 A;  1CHM A;  2BN7 A;  1XGS A;  4FO7 A;  4ZWU A;  4U1B A;  2GTX A;  1JAW A;  5FCH A;  2BWV A;  5CDV A;  2BHB A;  2BWX A;  4RZY A;  2Q93 A;  5D6E A;  2GG0 A;  5JHU A;  1WKM A;  2OKN A;  3BIT A;  4PNC A;  4U6W A;  2V6C A;  5FCF A;  1XGO A;  4U6C A;  2GG5 A;  3Q6D A;  4U70 A;  1B59 A;  4FLJ A;  1PV9 A;  2G6P A;  2MAT A;  4IU6 A;  1WL6 A;  1R58 A;  5E5B A;  3D27 A;  1WBQ A;  2GZ5 A;  1A16 A;  4IF7 A;  5CLS A;  1QXW A;  2GGB A;  4HXX A;  4FO8 A;  1KQ9 A;  2P98 A;  4FLL A;  2HOW A;  4ZWO A;  1YW8 A;  2GU5 A;  4JUQ A;  3IU8 A;  2NQ7 A;  2GU7 A;  3MAT A;  4U69 A;  5CIK A;  4R60 A;  2GU6 A;  3L24 A;  4OOK A;  4U71 A;  1XNZ A;  4IPA A;  4IKS A;  4RGZ 1;  4KM3 A;  2Q94 A;  1C21 A;  4A6W A;  2GGC A;  3FMR A;  2BWS A;  3IU9 A;  2GG9 A;  4IKU A;  2B3K A;  1B6A A;  2Q96 A;  2Q92 A;  3RVA A;  2BHA A;  1KQ0 A;  4B28 A;  4EGE A;  1MAT A;  5CDE A;  3BIQ A;  1BOA A;  1C24 A;  1N51 A;  1O0X A;  3FMQ A;  2EVM A;  4S00 A;  1WY2 A;  3PKB A;  4S2R P;  4A6V A;  2NQ6 A;  1XGM A;  3CTZ A;  2EVO A;  4U73 A;  4S2T P;  5D6F A;  2EVC A;  4U6Z A;  3MR1 A;  4IEC A;  1Y1N A;  3IU7 A;  1M35 A;  2BB7 A;  2GU4 A;  3TB5 A;  4FKC A;  2DFI A;  4RZZ A;  1W2M A;  3CB5 A;  3CB6 A;  2ADU A;  3IG4 A;  1YJ3 A;  3MX6 A;  2B3H A;  5CE6 A;  1WLR A;  1QXZ A;  1C22 A;  4FLI A;  3S6B A;  4U6E A;  3PKD A;  4FUK A;  1BN5 A;  2BWT A;  1WL9 A;  4MAT A;  4U75 A;  2B3L A;  5JFR A;  3PKA A;  1YW9 A;  1YW7 A;  2OAZ A;  2BWU A;  2GG3 A;  2GA2 A;  1WN1 A;  4IKT A;  4ZNG A;  4ZWP A;  1KP0 A;  2BWY A;  5CDL A;  5CNX A;  4QR8 A;  2BHD A;  1YVM A;  2P99 A;  2GG8 A;  2IW2 A;  1R5H A;  2GG7 A;  4IKR A;  1R5G A;  2BWW A;  4IDY A;  1C23 A;  2Q8K A;  4PV4 A;  2GG2 A;  3L7G A; 
#chains in the Genus database with same CATH topology
 5JI6 A;  2EA2 A;  3TAV A;  4S01 A;  2BH3 A;  2ZSG A;  2P9A A;  1QXY A;  3PKE A;  4FLK A;  4U76 A;  4U6J A;  3FM3 A;  2V3Z A;  3BIP A;  2BHC A;  1W7V A;  3PKC A;  1QZY A;  4Z7M A;  2V3Y A;  2V3X A;  1XGN A;  2Q95 A;  1C27 A;  3ROR A;  2EA4 A;  1CHM A;  2BN7 A;  1XGS A;  4FO7 A;  4ZWU A;  4U1B A;  2GTX A;  1JAW A;  5FCH A;  2BWV A;  5CDV A;  2BHB A;  2BWX A;  4RZY A;  2Q93 A;  5D6E A;  2GG0 A;  5JHU A;  1WKM A;  2OKN A;  3BIT A;  4PNC A;  4U6W A;  2V6C A;  5FCF A;  1XGO A;  4U6C A;  2GG5 A;  3Q6D A;  4U70 A;  1B59 A;  4FLJ A;  1PV9 A;  2G6P A;  2MAT A;  4IU6 A;  1WL6 A;  1R58 A;  5E5B A;  3D27 A;  1WBQ A;  2GZ5 A;  1A16 A;  4IF7 A;  5CLS A;  1QXW A;  2GGB A;  4HXX A;  4FO8 A;  1KQ9 A;  2P98 A;  4FLL A;  2HOW A;  4ZWO A;  1YW8 A;  2GU5 A;  4JUQ A;  3IU8 A;  2NQ7 A;  2GU7 A;  3MAT A;  4U69 A;  5CIK A;  4R60 A;  2GU6 A;  3L24 A;  4OOK A;  4U71 A;  1XNZ A;  4IPA A;  4IKS A;  4RGZ 1;  4KM3 A;  2Q94 A;  1C21 A;  4A6W A;  2GGC A;  3FMR A;  2BWS A;  3IU9 A;  2GG9 A;  4IKU A;  2B3K A;  1B6A A;  2Q96 A;  2Q92 A;  3RVA A;  2BHA A;  1KQ0 A;  4B28 A;  4EGE A;  1MAT A;  5CDE A;  3BIQ A;  1BOA A;  1C24 A;  1N51 A;  1O0X A;  3FMQ A;  2EVM A;  4S00 A;  1WY2 A;  3PKB A;  4S2R P;  4A6V A;  2NQ6 A;  1XGM A;  3CTZ A;  2EVO A;  4U73 A;  4S2T P;  5D6F A;  2EVC A;  4U6Z A;  3MR1 A;  4IEC A;  1Y1N A;  3IU7 A;  1M35 A;  2BB7 A;  2GU4 A;  3TB5 A;  4FKC A;  2DFI A;  4RZZ A;  1W2M A;  3CB5 A;  3CB6 A;  2ADU A;  3IG4 A;  1YJ3 A;  3MX6 A;  2B3H A;  5CE6 A;  1WLR A;  1QXZ A;  1C22 A;  4FLI A;  3S6B A;  4U6E A;  3PKD A;  4FUK A;  1BN5 A;  2BWT A;  1WL9 A;  4MAT A;  4U75 A;  2B3L A;  5JFR A;  3PKA A;  1YW9 A;  1YW7 A;  2OAZ A;  2BWU A;  2GG3 A;  2GA2 A;  1WN1 A;  4IKT A;  4ZNG A;  4ZWP A;  1KP0 A;  2BWY A;  5CDL A;  5CNX A;  4QR8 A;  2BHD A;  1YVM A;  2P99 A;  2GG8 A;  2IW2 A;  1R5H A;  2GG7 A;  4IKR A;  1R5G A;  2BWW A;  4IDY A;  1C23 A;  2Q8K A;  4PV4 A;  2GG2 A;  3L7G A; 
#chains in the Genus database with same CATH homology
 5JI6 A;  2EA2 A;  3TAV A;  4S01 A;  2BH3 A;  2ZSG A;  2P9A A;  1QXY A;  3PKE A;  4FLK A;  4U76 A;  4U6J A;  3FM3 A;  2V3Z A;  3BIP A;  2BHC A;  1W7V A;  3PKC A;  1QZY A;  4Z7M A;  2V3Y A;  2V3X A;  1XGN A;  2Q95 A;  1C27 A;  3ROR A;  2EA4 A;  1CHM A;  2BN7 A;  1XGS A;  4FO7 A;  4ZWU A;  4U1B A;  2GTX A;  1JAW A;  5FCH A;  2BWV A;  5CDV A;  2BHB A;  2BWX A;  4RZY A;  2Q93 A;  5D6E A;  2GG0 A;  5JHU A;  1WKM A;  2OKN A;  3BIT A;  4PNC A;  4U6W A;  2V6C A;  5FCF A;  1XGO A;  4U6C A;  2GG5 A;  3Q6D A;  4U70 A;  1B59 A;  4FLJ A;  1PV9 A;  2G6P A;  2MAT A;  4IU6 A;  1WL6 A;  1R58 A;  5E5B A;  3D27 A;  1WBQ A;  2GZ5 A;  1A16 A;  4IF7 A;  5CLS A;  1QXW A;  2GGB A;  4HXX A;  4FO8 A;  1KQ9 A;  2P98 A;  4FLL A;  2HOW A;  4ZWO A;  1YW8 A;  2GU5 A;  4JUQ A;  3IU8 A;  2NQ7 A;  2GU7 A;  3MAT A;  4U69 A;  5CIK A;  4R60 A;  2GU6 A;  3L24 A;  4OOK A;  4U71 A;  1XNZ A;  4IPA A;  4IKS A;  4RGZ 1;  4KM3 A;  2Q94 A;  1C21 A;  4A6W A;  2GGC A;  3FMR A;  2BWS A;  3IU9 A;  2GG9 A;  4IKU A;  2B3K A;  1B6A A;  2Q96 A;  2Q92 A;  3RVA A;  2BHA A;  1KQ0 A;  4B28 A;  4EGE A;  1MAT A;  5CDE A;  3BIQ A;  1BOA A;  1C24 A;  1N51 A;  1O0X A;  3FMQ A;  2EVM A;  4S00 A;  1WY2 A;  3PKB A;  4S2R P;  4A6V A;  2NQ6 A;  1XGM A;  3CTZ A;  2EVO A;  4U73 A;  4S2T P;  5D6F A;  2EVC A;  4U6Z A;  3MR1 A;  4IEC A;  1Y1N A;  3IU7 A;  1M35 A;  2BB7 A;  2GU4 A;  3TB5 A;  4FKC A;  2DFI A;  4RZZ A;  1W2M A;  3CB5 A;  3CB6 A;  2ADU A;  3IG4 A;  1YJ3 A;  3MX6 A;  2B3H A;  5CE6 A;  1WLR A;  1QXZ A;  1C22 A;  4FLI A;  3S6B A;  4U6E A;  3PKD A;  4FUK A;  1BN5 A;  2BWT A;  1WL9 A;  4MAT A;  4U75 A;  2B3L A;  5JFR A;  3PKA A;  1YW9 A;  1YW7 A;  2OAZ A;  2BWU A;  2GG3 A;  2GA2 A;  1WN1 A;  4IKT A;  4ZNG A;  4ZWP A;  1KP0 A;  2BWY A;  5CDL A;  5CNX A;  4QR8 A;  2BHD A;  1YVM A;  2P99 A;  2GG8 A;  2IW2 A;  1R5H A;  2GG7 A;  4IKR A;  1R5G A;  2BWW A;  4IDY A;  1C23 A;  2Q8K A;  4PV4 A;  2GG2 A;  3L7G A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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