4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
3IG4A 2GU7A 2IW2A 1R5GA 4A6WA 2BWVA 1WBQA 2GU4A 4PNCA 4U1BA 1BN5A 2Q93A 1BOAA 4FUKA 2OKNA 4IDYA 1XNZA 5JHUA 1YW9A 3BIPA 4U6CA 4HXXA 3FMRA 4S01A 4S2RP 4U70A 4FO8A 2BWYA 1C23A 4IKUA 2BWSA 2GU6A 1C27A 4U6EA 2GG2A 3TB5A 1WN1A 4ZNGA 2GTXA 4IECA 2BH3A 1XGMA 3BITA 2BWWA 3IU8A 4RZYA 2EA4A 2ZSGA 1WL6A 4Z7MA 4A6VA 4RGZ1 1WLRA 4FLIA 1R5HA 2Q96A 2V3ZA 2GA2A 2EVCA 5CDEA 4EGEA 1M35A 4ZWOA 1KQ0A 3Q6DA 5FCHA 2BHDA 2GG8A 2MATA 2BWUA 3PKAA 1PV9A 3PKDA 2GGCA 4ZWPA 1C22A 1XGOA 1KQ9A 1QZYA 2GG0A 3L7GA 4JUQA 4U75A 2Q95A 1A16A 2NQ6A 4MATA 5FCFA 3D27A 2BHAA 4ZWUA 2B3KA 2HOWA 2GG7A 4U76A 1YW8A 3CB5A 1WL9A 4U6ZA 1MATA 3FMQA 2GG3A 3MATA 2V6CA 3PKEA 4U6WA 5JFRA 1KP0A 1XGSA 2GU5A 2GG9A 3BIQA 3IU7A 3MR1A 2P9AA 5D6FA 3RVAA 1B59A 3CTZA 4PV4A 2BHCA 4FLKA 3RORA 4OOKA 2DFIA 2G6PA 5CIKA 2BWTA 2B3LA 4IKRA 4QR8A 1YVMA 4U71A 3PKBA 2GG5A 2Q8KA 1YJ3A 4IF7A 5E5BA 3L24A 2BWXA 4U6JA 2BHBA 1JAWA 1WKMA 1R58A 1QXZA 5CE6A 2EVMA 1QXWA 5CNXA 4FKCA 1YW7A 3TAVA 1W2MA 1WY2A 4FLJA 3S6BA 2B3HA 2BB7A 1C21A 2Q92A 3PKCA 2ADUA 4IKSA 3MX6A 4R60A 4U73A 2GZ5A 1O0XA 1XGNA 5D6EA 1QXYA 2NQ7A 4S00A 2GGBA 1W7VA 4S2TP 5CLSA 1Y1NA 3CB6A 4KM3A 1C24A 2P98A 3FM3A 4IU6A 2Q94A 5CDLA 2BN7A 1CHMA 2EVOA 2OAZA 4IKTA 1B6AA 2P99A 2V3YA 4RZZA 4FO7A 1N51A 4FLLA 4U69A 2EA2A 4IPAA 5CDVA 5JI6A 4B28A 3IU9A 2V3XA
chains in the Genus database with same CATH superfamily
3IG4A 2GU7A 2IW2A 1R5GA 4A6WA 2BWVA 1WBQA 2GU4A 4PNCA 4U1BA 1BN5A 2Q93A 1BOAA 4FUKA 2OKNA 4IDYA 1XNZA 5JHUA 1YW9A 3BIPA 4U6CA 4HXXA 3FMRA 4S01A 4S2RP 4U70A 4FO8A 2BWYA 1C23A 4IKUA 2BWSA 2GU6A 1C27A 4U6EA 2GG2A 3TB5A 1WN1A 4ZNGA 2GTXA 4IECA 2BH3A 1XGMA 3BITA 2BWWA 3IU8A 4RZYA 2EA4A 2ZSGA 1WL6A 4Z7MA 4A6VA 4RGZ1 1WLRA 4FLIA 1R5HA 2Q96A 2V3ZA 2GA2A 2EVCA 5CDEA 4EGEA 1M35A 4ZWOA 1KQ0A 3Q6DA 5FCHA 2BHDA 2GG8A 2MATA 2BWUA 3PKAA 1PV9A 3PKDA 2GGCA 4ZWPA 1C22A 1XGOA 1KQ9A 1QZYA 2GG0A 3L7GA 4JUQA 4U75A 2Q95A 1A16A 2NQ6A 4MATA 5FCFA 3D27A 2BHAA 4ZWUA 2B3KA 2HOWA 2GG7A 4U76A 1YW8A 3CB5A 1WL9A 4U6ZA 1MATA 3FMQA 2GG3A 3MATA 2V6CA 3PKEA 4U6WA 5JFRA 1KP0A 1XGSA 2GU5A 2GG9A 3BIQA 3IU7A 3MR1A 2P9AA 5D6FA 3RVAA 1B59A 3CTZA 4PV4A 2BHCA 4FLKA 3RORA 4OOKA 2DFIA 2G6PA 5CIKA 2BWTA 2B3LA 4IKRA 4QR8A 1YVMA 4U71A 3PKBA 2GG5A 2Q8KA 1YJ3A 4IF7A 5E5BA 3L24A 2BWXA 4U6JA 2BHBA 1JAWA 1WKMA 1R58A 1QXZA 5CE6A 2EVMA 1QXWA 5CNXA 4FKCA 1YW7A 3TAVA 1W2MA 1WY2A 4FLJA 3S6BA 2B3HA 2BB7A 1C21A 2Q92A 3PKCA 2ADUA 4IKSA 3MX6A 4R60A 4U73A 2GZ5A 1O0XA 1XGNA 5D6EA 1QXYA 2NQ7A 4S00A 2GGBA 1W7VA 4S2TP 5CLSA 1Y1NA 3CB6A 4KM3A 1C24A 2P98A 3FM3A 4IU6A 2Q94A 5CDLA 2BN7A 1CHMA 2EVOA 2OAZA 4IKTA 1B6AA 2P99A 2V3YA 4RZZA 4FO7A 1N51A 4FLLA 4U69A 2EA2A 4IPAA 5CDVA 5JI6A 4B28A 3IU9A 2V3XA
chains in the Genus database with same CATH topology
3IG4A 2GU7A 2IW2A 1R5GA 4A6WA 2BWVA 1WBQA 2GU4A 4PNCA 4U1BA 1BN5A 2Q93A 1BOAA 4FUKA 2OKNA 4IDYA 1XNZA 5JHUA 1YW9A 3BIPA 4U6CA 4HXXA 3FMRA 4S01A 4S2RP 4U70A 4FO8A 2BWYA 1C23A 4IKUA 2BWSA 2GU6A 1C27A 4U6EA 2GG2A 3TB5A 1WN1A 4ZNGA 2GTXA 4IECA 2BH3A 1XGMA 3BITA 2BWWA 3IU8A 4RZYA 2EA4A 2ZSGA 1WL6A 4Z7MA 4A6VA 4RGZ1 1WLRA 4FLIA 1R5HA 2Q96A 2V3ZA 2GA2A 2EVCA 5CDEA 4EGEA 1M35A 4ZWOA 1KQ0A 3Q6DA 5FCHA 2BHDA 2GG8A 2MATA 2BWUA 3PKAA 1PV9A 3PKDA 2GGCA 4ZWPA 1C22A 1XGOA 1KQ9A 1QZYA 2GG0A 3L7GA 4JUQA 4U75A 2Q95A 1A16A 2NQ6A 4MATA 5FCFA 3D27A 2BHAA 4ZWUA 2B3KA 2HOWA 2GG7A 4U76A 1YW8A 3CB5A 1WL9A 4U6ZA 1MATA 3FMQA 2GG3A 3MATA 2V6CA 3PKEA 4U6WA 5JFRA 1KP0A 1XGSA 2GU5A 2GG9A 3BIQA 3IU7A 3MR1A 2P9AA 5D6FA 3RVAA 1B59A 3CTZA 4PV4A 2BHCA 4FLKA 3RORA 4OOKA 2DFIA 2G6PA 5CIKA 2BWTA 2B3LA 4IKRA 4QR8A 1YVMA 4U71A 3PKBA 2GG5A 2Q8KA 1YJ3A 4IF7A 5E5BA 3L24A 2BWXA 4U6JA 2BHBA 1JAWA 1WKMA 1R58A 1QXZA 5CE6A 2EVMA 1QXWA 5CNXA 4FKCA 1YW7A 3TAVA 1W2MA 1WY2A 4FLJA 3S6BA 2B3HA 2BB7A 1C21A 2Q92A 3PKCA 2ADUA 4IKSA 3MX6A 4R60A 4U73A 2GZ5A 1O0XA 1XGNA 5D6EA 1QXYA 2NQ7A 4S00A 2GGBA 1W7VA 4S2TP 5CLSA 1Y1NA 3CB6A 4KM3A 1C24A 2P98A 3FM3A 4IU6A 2Q94A 5CDLA 2BN7A 1CHMA 2EVOA 2OAZA 4IKTA 1B6AA 2P99A 2V3YA 4RZZA 4FO7A 1N51A 4FLLA 4U69A 2EA2A 4IPAA 5CDVA 5JI6A 4B28A 3IU9A 2V3XA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3IG4 A;  2GU7 A;  2IW2 A;  1R5G A;  4A6W A;  2BWV A;  1WBQ A;  2GU4 A;  4PNC A;  4U1B A;  1BN5 A;  2Q93 A;  1BOA A;  4FUK A;  2OKN A;  4IDY A;  1XNZ A;  5JHU A;  1YW9 A;  3BIP A;  4U6C A;  4HXX A;  3FMR A;  4S01 A;  4S2R P;  4U70 A;  4FO8 A;  2BWY A;  1C23 A;  4IKU A;  2BWS A;  2GU6 A;  1C27 A;  4U6E A;  2GG2 A;  3TB5 A;  1WN1 A;  4ZNG A;  2GTX A;  4IEC A;  2BH3 A;  1XGM A;  3BIT A;  2BWW A;  3IU8 A;  4RZY A;  2EA4 A;  2ZSG A;  1WL6 A;  4Z7M A;  4A6V A;  4RGZ 1;  1WLR A;  4FLI A;  1R5H A;  2Q96 A;  2V3Z A;  2GA2 A;  2EVC A;  5CDE A;  4EGE A;  1M35 A;  4ZWO A;  1KQ0 A;  3Q6D A;  5FCH A;  2BHD A;  2GG8 A;  2MAT A;  2BWU A;  3PKA A;  1PV9 A;  3PKD A;  2GGC A;  4ZWP A;  1C22 A;  1XGO A;  1KQ9 A;  1QZY A;  2GG0 A;  3L7G A;  4JUQ A;  4U75 A;  2Q95 A;  1A16 A;  2NQ6 A;  4MAT A;  5FCF A;  3D27 A;  2BHA A;  4ZWU A;  2B3K A;  2HOW A;  2GG7 A;  4U76 A;  1YW8 A;  3CB5 A;  1WL9 A;  4U6Z A;  1MAT A;  3FMQ A;  2GG3 A;  3MAT A;  2V6C A;  3PKE A;  4U6W A;  5JFR A;  1KP0 A;  1XGS A;  2GU5 A;  2GG9 A;  3BIQ A;  3IU7 A;  3MR1 A;  2P9A A;  5D6F A;  3RVA A;  1B59 A;  3CTZ A;  4PV4 A;  2BHC A;  4FLK A;  3ROR A;  4OOK A;  2DFI A;  2G6P A;  5CIK A;  2BWT A;  2B3L A;  4IKR A;  4QR8 A;  1YVM A;  4U71 A;  3PKB A;  2GG5 A;  2Q8K A;  1YJ3 A;  4IF7 A;  5E5B A;  3L24 A;  2BWX A;  4U6J A;  2BHB A;  1JAW A;  1WKM A;  1R58 A;  1QXZ A;  5CE6 A;  2EVM A;  1QXW A;  5CNX A;  4FKC A;  1YW7 A;  3TAV A;  1W2M A;  1WY2 A;  4FLJ A;  3S6B A;  2B3H A;  2BB7 A;  1C21 A;  2Q92 A;  3PKC A;  2ADU A;  4IKS A;  3MX6 A;  4R60 A;  4U73 A;  2GZ5 A;  1O0X A;  1XGN A;  5D6E A;  1QXY A;  2NQ7 A;  4S00 A;  2GGB A;  1W7V A;  4S2T P;  5CLS A;  1Y1N A;  3CB6 A;  4KM3 A;  1C24 A;  2P98 A;  3FM3 A;  4IU6 A;  2Q94 A;  5CDL A;  2BN7 A;  1CHM A;  2EVO A;  2OAZ A;  4IKT A;  1B6A A;  2P99 A;  2V3Y A;  4RZZ A;  4FO7 A;  1N51 A;  4FLL A;  4U69 A;  2EA2 A;  4IPA A;  5CDV A;  5JI6 A;  4B28 A;  3IU9 A;  2V3X A; 
#chains in the Genus database with same CATH topology
 3IG4 A;  2GU7 A;  2IW2 A;  1R5G A;  4A6W A;  2BWV A;  1WBQ A;  2GU4 A;  4PNC A;  4U1B A;  1BN5 A;  2Q93 A;  1BOA A;  4FUK A;  2OKN A;  4IDY A;  1XNZ A;  5JHU A;  1YW9 A;  3BIP A;  4U6C A;  4HXX A;  3FMR A;  4S01 A;  4S2R P;  4U70 A;  4FO8 A;  2BWY A;  1C23 A;  4IKU A;  2BWS A;  2GU6 A;  1C27 A;  4U6E A;  2GG2 A;  3TB5 A;  1WN1 A;  4ZNG A;  2GTX A;  4IEC A;  2BH3 A;  1XGM A;  3BIT A;  2BWW A;  3IU8 A;  4RZY A;  2EA4 A;  2ZSG A;  1WL6 A;  4Z7M A;  4A6V A;  4RGZ 1;  1WLR A;  4FLI A;  1R5H A;  2Q96 A;  2V3Z A;  2GA2 A;  2EVC A;  5CDE A;  4EGE A;  1M35 A;  4ZWO A;  1KQ0 A;  3Q6D A;  5FCH A;  2BHD A;  2GG8 A;  2MAT A;  2BWU A;  3PKA A;  1PV9 A;  3PKD A;  2GGC A;  4ZWP A;  1C22 A;  1XGO A;  1KQ9 A;  1QZY A;  2GG0 A;  3L7G A;  4JUQ A;  4U75 A;  2Q95 A;  1A16 A;  2NQ6 A;  4MAT A;  5FCF A;  3D27 A;  2BHA A;  4ZWU A;  2B3K A;  2HOW A;  2GG7 A;  4U76 A;  1YW8 A;  3CB5 A;  1WL9 A;  4U6Z A;  1MAT A;  3FMQ A;  2GG3 A;  3MAT A;  2V6C A;  3PKE A;  4U6W A;  5JFR A;  1KP0 A;  1XGS A;  2GU5 A;  2GG9 A;  3BIQ A;  3IU7 A;  3MR1 A;  2P9A A;  5D6F A;  3RVA A;  1B59 A;  3CTZ A;  4PV4 A;  2BHC A;  4FLK A;  3ROR A;  4OOK A;  2DFI A;  2G6P A;  5CIK A;  2BWT A;  2B3L A;  4IKR A;  4QR8 A;  1YVM A;  4U71 A;  3PKB A;  2GG5 A;  2Q8K A;  1YJ3 A;  4IF7 A;  5E5B A;  3L24 A;  2BWX A;  4U6J A;  2BHB A;  1JAW A;  1WKM A;  1R58 A;  1QXZ A;  5CE6 A;  2EVM A;  1QXW A;  5CNX A;  4FKC A;  1YW7 A;  3TAV A;  1W2M A;  1WY2 A;  4FLJ A;  3S6B A;  2B3H A;  2BB7 A;  1C21 A;  2Q92 A;  3PKC A;  2ADU A;  4IKS A;  3MX6 A;  4R60 A;  4U73 A;  2GZ5 A;  1O0X A;  1XGN A;  5D6E A;  1QXY A;  2NQ7 A;  4S00 A;  2GGB A;  1W7V A;  4S2T P;  5CLS A;  1Y1N A;  3CB6 A;  4KM3 A;  1C24 A;  2P98 A;  3FM3 A;  4IU6 A;  2Q94 A;  5CDL A;  2BN7 A;  1CHM A;  2EVO A;  2OAZ A;  4IKT A;  1B6A A;  2P99 A;  2V3Y A;  4RZZ A;  4FO7 A;  1N51 A;  4FLL A;  4U69 A;  2EA2 A;  4IPA A;  5CDV A;  5JI6 A;  4B28 A;  3IU9 A;  2V3X A; 
#chains in the Genus database with same CATH homology
 3IG4 A;  2GU7 A;  2IW2 A;  1R5G A;  4A6W A;  2BWV A;  1WBQ A;  2GU4 A;  4PNC A;  4U1B A;  1BN5 A;  2Q93 A;  1BOA A;  4FUK A;  2OKN A;  4IDY A;  1XNZ A;  5JHU A;  1YW9 A;  3BIP A;  4U6C A;  4HXX A;  3FMR A;  4S01 A;  4S2R P;  4U70 A;  4FO8 A;  2BWY A;  1C23 A;  4IKU A;  2BWS A;  2GU6 A;  1C27 A;  4U6E A;  2GG2 A;  3TB5 A;  1WN1 A;  4ZNG A;  2GTX A;  4IEC A;  2BH3 A;  1XGM A;  3BIT A;  2BWW A;  3IU8 A;  4RZY A;  2EA4 A;  2ZSG A;  1WL6 A;  4Z7M A;  4A6V A;  4RGZ 1;  1WLR A;  4FLI A;  1R5H A;  2Q96 A;  2V3Z A;  2GA2 A;  2EVC A;  5CDE A;  4EGE A;  1M35 A;  4ZWO A;  1KQ0 A;  3Q6D A;  5FCH A;  2BHD A;  2GG8 A;  2MAT A;  2BWU A;  3PKA A;  1PV9 A;  3PKD A;  2GGC A;  4ZWP A;  1C22 A;  1XGO A;  1KQ9 A;  1QZY A;  2GG0 A;  3L7G A;  4JUQ A;  4U75 A;  2Q95 A;  1A16 A;  2NQ6 A;  4MAT A;  5FCF A;  3D27 A;  2BHA A;  4ZWU A;  2B3K A;  2HOW A;  2GG7 A;  4U76 A;  1YW8 A;  3CB5 A;  1WL9 A;  4U6Z A;  1MAT A;  3FMQ A;  2GG3 A;  3MAT A;  2V6C A;  3PKE A;  4U6W A;  5JFR A;  1KP0 A;  1XGS A;  2GU5 A;  2GG9 A;  3BIQ A;  3IU7 A;  3MR1 A;  2P9A A;  5D6F A;  3RVA A;  1B59 A;  3CTZ A;  4PV4 A;  2BHC A;  4FLK A;  3ROR A;  4OOK A;  2DFI A;  2G6P A;  5CIK A;  2BWT A;  2B3L A;  4IKR A;  4QR8 A;  1YVM A;  4U71 A;  3PKB A;  2GG5 A;  2Q8K A;  1YJ3 A;  4IF7 A;  5E5B A;  3L24 A;  2BWX A;  4U6J A;  2BHB A;  1JAW A;  1WKM A;  1R58 A;  1QXZ A;  5CE6 A;  2EVM A;  1QXW A;  5CNX A;  4FKC A;  1YW7 A;  3TAV A;  1W2M A;  1WY2 A;  4FLJ A;  3S6B A;  2B3H A;  2BB7 A;  1C21 A;  2Q92 A;  3PKC A;  2ADU A;  4IKS A;  3MX6 A;  4R60 A;  4U73 A;  2GZ5 A;  1O0X A;  1XGN A;  5D6E A;  1QXY A;  2NQ7 A;  4S00 A;  2GGB A;  1W7V A;  4S2T P;  5CLS A;  1Y1N A;  3CB6 A;  4KM3 A;  1C24 A;  2P98 A;  3FM3 A;  4IU6 A;  2Q94 A;  5CDL A;  2BN7 A;  1CHM A;  2EVO A;  2OAZ A;  4IKT A;  1B6A A;  2P99 A;  2V3Y A;  4RZZ A;  4FO7 A;  1N51 A;  4FLL A;  4U69 A;  2EA2 A;  4IPA A;  5CDV A;  5JI6 A;  4B28 A;  3IU9 A;  2V3X A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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