4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
2BWUA 1R58A 2GG0A 2OKNA 2Q93A 4RGZ1 3D27A 1QZYA 3MATA 4OOKA 4FLIA 2GG9A 5FCFA 3CTZA 2ADUA 1MATA 1O0XA 2BWVA 1XGNA 4FLLA 5JFRA 1BN5A 1XGOA 5CDLA 4QR8A 2GZ5A 1W2MA 2BWTA 2BHCA 1YW9A 1KP0A 3IU9A 5FCHA 1WKMA 3S6BA 2V3ZA 5CDEA 1WY2A 2NQ6A 3CB5A 3FMQA 3L7GA 1C27A 2Q92A 3PKBA 5CNXA 4ZWUA 2BWYA 2P9AA 1WBQA 3MR1A 3BITA 2GGBA 4U6EA 4U75A 5CLSA 5JI6A 2GTXA 1XGSA 1N51A 2GG7A 1QXYA 4U6WA 4A6VA 2HOWA 4U6CA 4FUKA 3IU8A 3FM3A 3PKDA 1JAWA 2DFIA 1B59A 2V3XA 4FLJA 2EVOA 4IU6A 4RZYA 4ZWOA 2GG2A 3RVAA 4U69A 4U6ZA 2EVMA 1BOAA 1C24A 5E5BA 2B3KA 4HXXA 2Q8KA 2GG3A 4U73A 1R5HA 5D6FA 4IF7A 3TAVA 3IG4A 4JUQA 5JHUA 1C21A 1YVMA 1W7VA 1A16A 2EVCA 1CHMA 3CB6A 4MATA 2P99A 2B3HA 4EGEA 3L24A 1C23A 2B3LA 2BH3A 1QXWA 4PNCA 3Q6DA 4IKSA 3PKEA 4IECA 2IW2A 1XGMA 2GU5A 5CE6A 1QXZA 2GA2A 4IKRA 1M35A 3FMRA 1WN1A 4S2RP 5CIKA 2EA2A 1R5GA 1Y1NA 2BWSA 4FO7A 4U6JA 4KM3A 3IU7A 2GU4A 4PV4A 4ZNGA 1YW7A 2V6CA 4S01A 4FO8A 4IDYA 2V3YA 2BHDA 4B28A 1B6AA 4Z7MA 1KQ9A 2Q95A 3BIPA 4IKUA 2BHBA 2ZSGA 2Q96A 3TB5A 1YJ3A 5CDVA 4S2TP 4IKTA 2P98A 1XNZA 3RORA 4FKCA 1PV9A 2GG5A 4U70A 3MX6A 1KQ0A 3BIQA 3PKAA 2Q94A 2GU7A 2GG8A 2MATA 2BWXA 2OAZA 2NQ7A 2BB7A 2BHAA 2GU6A 2BN7A 4S00A 4R60A 2EA4A 4IPAA 5D6EA 4A6WA 4U76A 1WL6A 4FLKA 1C22A 1YW8A 4U71A 4U1BA 4ZWPA 2BWWA 1WL9A 1WLRA 4RZZA 2G6PA 3PKCA 2GGCA
chains in the Genus database with same CATH superfamily
2BWUA 1R58A 2GG0A 2OKNA 2Q93A 4RGZ1 3D27A 1QZYA 3MATA 4OOKA 4FLIA 2GG9A 5FCFA 3CTZA 2ADUA 1MATA 1O0XA 2BWVA 1XGNA 4FLLA 5JFRA 1BN5A 1XGOA 5CDLA 4QR8A 2GZ5A 1W2MA 2BWTA 2BHCA 1YW9A 1KP0A 3IU9A 5FCHA 1WKMA 3S6BA 2V3ZA 5CDEA 1WY2A 2NQ6A 3CB5A 3FMQA 3L7GA 1C27A 2Q92A 3PKBA 5CNXA 4ZWUA 2BWYA 2P9AA 1WBQA 3MR1A 3BITA 2GGBA 4U6EA 4U75A 5CLSA 5JI6A 2GTXA 1XGSA 1N51A 2GG7A 1QXYA 4U6WA 4A6VA 2HOWA 4U6CA 4FUKA 3IU8A 3FM3A 3PKDA 1JAWA 2DFIA 1B59A 2V3XA 4FLJA 2EVOA 4IU6A 4RZYA 4ZWOA 2GG2A 3RVAA 4U69A 4U6ZA 2EVMA 1BOAA 1C24A 5E5BA 2B3KA 4HXXA 2Q8KA 2GG3A 4U73A 1R5HA 5D6FA 4IF7A 3TAVA 3IG4A 4JUQA 5JHUA 1C21A 1YVMA 1W7VA 1A16A 2EVCA 1CHMA 3CB6A 4MATA 2P99A 2B3HA 4EGEA 3L24A 1C23A 2B3LA 2BH3A 1QXWA 4PNCA 3Q6DA 4IKSA 3PKEA 4IECA 2IW2A 1XGMA 2GU5A 5CE6A 1QXZA 2GA2A 4IKRA 1M35A 3FMRA 1WN1A 4S2RP 5CIKA 2EA2A 1R5GA 1Y1NA 2BWSA 4FO7A 4U6JA 4KM3A 3IU7A 2GU4A 4PV4A 4ZNGA 1YW7A 2V6CA 4S01A 4FO8A 4IDYA 2V3YA 2BHDA 4B28A 1B6AA 4Z7MA 1KQ9A 2Q95A 3BIPA 4IKUA 2BHBA 2ZSGA 2Q96A 3TB5A 1YJ3A 5CDVA 4S2TP 4IKTA 2P98A 1XNZA 3RORA 4FKCA 1PV9A 2GG5A 4U70A 3MX6A 1KQ0A 3BIQA 3PKAA 2Q94A 2GU7A 2GG8A 2MATA 2BWXA 2OAZA 2NQ7A 2BB7A 2BHAA 2GU6A 2BN7A 4S00A 4R60A 2EA4A 4IPAA 5D6EA 4A6WA 4U76A 1WL6A 4FLKA 1C22A 1YW8A 4U71A 4U1BA 4ZWPA 2BWWA 1WL9A 1WLRA 4RZZA 2G6PA 3PKCA 2GGCA
chains in the Genus database with same CATH topology
2BWUA 1R58A 2GG0A 2OKNA 2Q93A 4RGZ1 3D27A 1QZYA 3MATA 4OOKA 4FLIA 2GG9A 5FCFA 3CTZA 2ADUA 1MATA 1O0XA 2BWVA 1XGNA 4FLLA 5JFRA 1BN5A 1XGOA 5CDLA 4QR8A 2GZ5A 1W2MA 2BWTA 2BHCA 1YW9A 1KP0A 3IU9A 5FCHA 1WKMA 3S6BA 2V3ZA 5CDEA 1WY2A 2NQ6A 3CB5A 3FMQA 3L7GA 1C27A 2Q92A 3PKBA 5CNXA 4ZWUA 2BWYA 2P9AA 1WBQA 3MR1A 3BITA 2GGBA 4U6EA 4U75A 5CLSA 5JI6A 2GTXA 1XGSA 1N51A 2GG7A 1QXYA 4U6WA 4A6VA 2HOWA 4U6CA 4FUKA 3IU8A 3FM3A 3PKDA 1JAWA 2DFIA 1B59A 2V3XA 4FLJA 2EVOA 4IU6A 4RZYA 4ZWOA 2GG2A 3RVAA 4U69A 4U6ZA 2EVMA 1BOAA 1C24A 5E5BA 2B3KA 4HXXA 2Q8KA 2GG3A 4U73A 1R5HA 5D6FA 4IF7A 3TAVA 3IG4A 4JUQA 5JHUA 1C21A 1YVMA 1W7VA 1A16A 2EVCA 1CHMA 3CB6A 4MATA 2P99A 2B3HA 4EGEA 3L24A 1C23A 2B3LA 2BH3A 1QXWA 4PNCA 3Q6DA 4IKSA 3PKEA 4IECA 2IW2A 1XGMA 2GU5A 5CE6A 1QXZA 2GA2A 4IKRA 1M35A 3FMRA 1WN1A 4S2RP 5CIKA 2EA2A 1R5GA 1Y1NA 2BWSA 4FO7A 4U6JA 4KM3A 3IU7A 2GU4A 4PV4A 4ZNGA 1YW7A 2V6CA 4S01A 4FO8A 4IDYA 2V3YA 2BHDA 4B28A 1B6AA 4Z7MA 1KQ9A 2Q95A 3BIPA 4IKUA 2BHBA 2ZSGA 2Q96A 3TB5A 1YJ3A 5CDVA 4S2TP 4IKTA 2P98A 1XNZA 3RORA 4FKCA 1PV9A 2GG5A 4U70A 3MX6A 1KQ0A 3BIQA 3PKAA 2Q94A 2GU7A 2GG8A 2MATA 2BWXA 2OAZA 2NQ7A 2BB7A 2BHAA 2GU6A 2BN7A 4S00A 4R60A 2EA4A 4IPAA 5D6EA 4A6WA 4U76A 1WL6A 4FLKA 1C22A 1YW8A 4U71A 4U1BA 4ZWPA 2BWWA 1WL9A 1WLRA 4RZZA 2G6PA 3PKCA 2GGCA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BWU A;  1R58 A;  2GG0 A;  2OKN A;  2Q93 A;  4RGZ 1;  3D27 A;  1QZY A;  3MAT A;  4OOK A;  4FLI A;  2GG9 A;  5FCF A;  3CTZ A;  2ADU A;  1MAT A;  1O0X A;  2BWV A;  1XGN A;  4FLL A;  5JFR A;  1BN5 A;  1XGO A;  5CDL A;  4QR8 A;  2GZ5 A;  1W2M A;  2BWT A;  2BHC A;  1YW9 A;  1KP0 A;  3IU9 A;  5FCH A;  1WKM A;  3S6B A;  2V3Z A;  5CDE A;  1WY2 A;  2NQ6 A;  3CB5 A;  3FMQ A;  3L7G A;  1C27 A;  2Q92 A;  3PKB A;  5CNX A;  4ZWU A;  2BWY A;  2P9A A;  1WBQ A;  3MR1 A;  3BIT A;  2GGB A;  4U6E A;  4U75 A;  5CLS A;  5JI6 A;  2GTX A;  1XGS A;  1N51 A;  2GG7 A;  1QXY A;  4U6W A;  4A6V A;  2HOW A;  4U6C A;  4FUK A;  3IU8 A;  3FM3 A;  3PKD A;  1JAW A;  2DFI A;  1B59 A;  2V3X A;  4FLJ A;  2EVO A;  4IU6 A;  4RZY A;  4ZWO A;  2GG2 A;  3RVA A;  4U69 A;  4U6Z A;  2EVM A;  1BOA A;  1C24 A;  5E5B A;  2B3K A;  4HXX A;  2Q8K A;  2GG3 A;  4U73 A;  1R5H A;  5D6F A;  4IF7 A;  3TAV A;  3IG4 A;  4JUQ A;  5JHU A;  1C21 A;  1YVM A;  1W7V A;  1A16 A;  2EVC A;  1CHM A;  3CB6 A;  4MAT A;  2P99 A;  2B3H A;  4EGE A;  3L24 A;  1C23 A;  2B3L A;  2BH3 A;  1QXW A;  4PNC A;  3Q6D A;  4IKS A;  3PKE A;  4IEC A;  2IW2 A;  1XGM A;  2GU5 A;  5CE6 A;  1QXZ A;  2GA2 A;  4IKR A;  1M35 A;  3FMR A;  1WN1 A;  4S2R P;  5CIK A;  2EA2 A;  1R5G A;  1Y1N A;  2BWS A;  4FO7 A;  4U6J A;  4KM3 A;  3IU7 A;  2GU4 A;  4PV4 A;  4ZNG A;  1YW7 A;  2V6C A;  4S01 A;  4FO8 A;  4IDY A;  2V3Y A;  2BHD A;  4B28 A;  1B6A A;  4Z7M A;  1KQ9 A;  2Q95 A;  3BIP A;  4IKU A;  2BHB A;  2ZSG A;  2Q96 A;  3TB5 A;  1YJ3 A;  5CDV A;  4S2T P;  4IKT A;  2P98 A;  1XNZ A;  3ROR A;  4FKC A;  1PV9 A;  2GG5 A;  4U70 A;  3MX6 A;  1KQ0 A;  3BIQ A;  3PKA A;  2Q94 A;  2GU7 A;  2GG8 A;  2MAT A;  2BWX A;  2OAZ A;  2NQ7 A;  2BB7 A;  2BHA A;  2GU6 A;  2BN7 A;  4S00 A;  4R60 A;  2EA4 A;  4IPA A;  5D6E A;  4A6W A;  4U76 A;  1WL6 A;  4FLK A;  1C22 A;  1YW8 A;  4U71 A;  4U1B A;  4ZWP A;  2BWW A;  1WL9 A;  1WLR A;  4RZZ A;  2G6P A;  3PKC A;  2GGC A; 
#chains in the Genus database with same CATH topology
 2BWU A;  1R58 A;  2GG0 A;  2OKN A;  2Q93 A;  4RGZ 1;  3D27 A;  1QZY A;  3MAT A;  4OOK A;  4FLI A;  2GG9 A;  5FCF A;  3CTZ A;  2ADU A;  1MAT A;  1O0X A;  2BWV A;  1XGN A;  4FLL A;  5JFR A;  1BN5 A;  1XGO A;  5CDL A;  4QR8 A;  2GZ5 A;  1W2M A;  2BWT A;  2BHC A;  1YW9 A;  1KP0 A;  3IU9 A;  5FCH A;  1WKM A;  3S6B A;  2V3Z A;  5CDE A;  1WY2 A;  2NQ6 A;  3CB5 A;  3FMQ A;  3L7G A;  1C27 A;  2Q92 A;  3PKB A;  5CNX A;  4ZWU A;  2BWY A;  2P9A A;  1WBQ A;  3MR1 A;  3BIT A;  2GGB A;  4U6E A;  4U75 A;  5CLS A;  5JI6 A;  2GTX A;  1XGS A;  1N51 A;  2GG7 A;  1QXY A;  4U6W A;  4A6V A;  2HOW A;  4U6C A;  4FUK A;  3IU8 A;  3FM3 A;  3PKD A;  1JAW A;  2DFI A;  1B59 A;  2V3X A;  4FLJ A;  2EVO A;  4IU6 A;  4RZY A;  4ZWO A;  2GG2 A;  3RVA A;  4U69 A;  4U6Z A;  2EVM A;  1BOA A;  1C24 A;  5E5B A;  2B3K A;  4HXX A;  2Q8K A;  2GG3 A;  4U73 A;  1R5H A;  5D6F A;  4IF7 A;  3TAV A;  3IG4 A;  4JUQ A;  5JHU A;  1C21 A;  1YVM A;  1W7V A;  1A16 A;  2EVC A;  1CHM A;  3CB6 A;  4MAT A;  2P99 A;  2B3H A;  4EGE A;  3L24 A;  1C23 A;  2B3L A;  2BH3 A;  1QXW A;  4PNC A;  3Q6D A;  4IKS A;  3PKE A;  4IEC A;  2IW2 A;  1XGM A;  2GU5 A;  5CE6 A;  1QXZ A;  2GA2 A;  4IKR A;  1M35 A;  3FMR A;  1WN1 A;  4S2R P;  5CIK A;  2EA2 A;  1R5G A;  1Y1N A;  2BWS A;  4FO7 A;  4U6J A;  4KM3 A;  3IU7 A;  2GU4 A;  4PV4 A;  4ZNG A;  1YW7 A;  2V6C A;  4S01 A;  4FO8 A;  4IDY A;  2V3Y A;  2BHD A;  4B28 A;  1B6A A;  4Z7M A;  1KQ9 A;  2Q95 A;  3BIP A;  4IKU A;  2BHB A;  2ZSG A;  2Q96 A;  3TB5 A;  1YJ3 A;  5CDV A;  4S2T P;  4IKT A;  2P98 A;  1XNZ A;  3ROR A;  4FKC A;  1PV9 A;  2GG5 A;  4U70 A;  3MX6 A;  1KQ0 A;  3BIQ A;  3PKA A;  2Q94 A;  2GU7 A;  2GG8 A;  2MAT A;  2BWX A;  2OAZ A;  2NQ7 A;  2BB7 A;  2BHA A;  2GU6 A;  2BN7 A;  4S00 A;  4R60 A;  2EA4 A;  4IPA A;  5D6E A;  4A6W A;  4U76 A;  1WL6 A;  4FLK A;  1C22 A;  1YW8 A;  4U71 A;  4U1B A;  4ZWP A;  2BWW A;  1WL9 A;  1WLR A;  4RZZ A;  2G6P A;  3PKC A;  2GGC A; 
#chains in the Genus database with same CATH homology
 2BWU A;  1R58 A;  2GG0 A;  2OKN A;  2Q93 A;  4RGZ 1;  3D27 A;  1QZY A;  3MAT A;  4OOK A;  4FLI A;  2GG9 A;  5FCF A;  3CTZ A;  2ADU A;  1MAT A;  1O0X A;  2BWV A;  1XGN A;  4FLL A;  5JFR A;  1BN5 A;  1XGO A;  5CDL A;  4QR8 A;  2GZ5 A;  1W2M A;  2BWT A;  2BHC A;  1YW9 A;  1KP0 A;  3IU9 A;  5FCH A;  1WKM A;  3S6B A;  2V3Z A;  5CDE A;  1WY2 A;  2NQ6 A;  3CB5 A;  3FMQ A;  3L7G A;  1C27 A;  2Q92 A;  3PKB A;  5CNX A;  4ZWU A;  2BWY A;  2P9A A;  1WBQ A;  3MR1 A;  3BIT A;  2GGB A;  4U6E A;  4U75 A;  5CLS A;  5JI6 A;  2GTX A;  1XGS A;  1N51 A;  2GG7 A;  1QXY A;  4U6W A;  4A6V A;  2HOW A;  4U6C A;  4FUK A;  3IU8 A;  3FM3 A;  3PKD A;  1JAW A;  2DFI A;  1B59 A;  2V3X A;  4FLJ A;  2EVO A;  4IU6 A;  4RZY A;  4ZWO A;  2GG2 A;  3RVA A;  4U69 A;  4U6Z A;  2EVM A;  1BOA A;  1C24 A;  5E5B A;  2B3K A;  4HXX A;  2Q8K A;  2GG3 A;  4U73 A;  1R5H A;  5D6F A;  4IF7 A;  3TAV A;  3IG4 A;  4JUQ A;  5JHU A;  1C21 A;  1YVM A;  1W7V A;  1A16 A;  2EVC A;  1CHM A;  3CB6 A;  4MAT A;  2P99 A;  2B3H A;  4EGE A;  3L24 A;  1C23 A;  2B3L A;  2BH3 A;  1QXW A;  4PNC A;  3Q6D A;  4IKS A;  3PKE A;  4IEC A;  2IW2 A;  1XGM A;  2GU5 A;  5CE6 A;  1QXZ A;  2GA2 A;  4IKR A;  1M35 A;  3FMR A;  1WN1 A;  4S2R P;  5CIK A;  2EA2 A;  1R5G A;  1Y1N A;  2BWS A;  4FO7 A;  4U6J A;  4KM3 A;  3IU7 A;  2GU4 A;  4PV4 A;  4ZNG A;  1YW7 A;  2V6C A;  4S01 A;  4FO8 A;  4IDY A;  2V3Y A;  2BHD A;  4B28 A;  1B6A A;  4Z7M A;  1KQ9 A;  2Q95 A;  3BIP A;  4IKU A;  2BHB A;  2ZSG A;  2Q96 A;  3TB5 A;  1YJ3 A;  5CDV A;  4S2T P;  4IKT A;  2P98 A;  1XNZ A;  3ROR A;  4FKC A;  1PV9 A;  2GG5 A;  4U70 A;  3MX6 A;  1KQ0 A;  3BIQ A;  3PKA A;  2Q94 A;  2GU7 A;  2GG8 A;  2MAT A;  2BWX A;  2OAZ A;  2NQ7 A;  2BB7 A;  2BHA A;  2GU6 A;  2BN7 A;  4S00 A;  4R60 A;  2EA4 A;  4IPA A;  5D6E A;  4A6W A;  4U76 A;  1WL6 A;  4FLK A;  1C22 A;  1YW8 A;  4U71 A;  4U1B A;  4ZWP A;  2BWW A;  1WL9 A;  1WLR A;  4RZZ A;  2G6P A;  3PKC A;  2GGC A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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