4U75A

Hsmetap (f309m) in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u75A00
3PKCA 3MX6A 3IU8A 2Q94A 2MATA 1MATA 4A6WA 5CE6A 2BWYA 5JFRA 3L7GA 3IU7A 2ADUA 3PKEA 4IKTA 4FO7A 1WY2A 2GZ5A 3TAVA 3RVAA 1KQ9A 3FMRA 3CB5A 2OKNA 3BITA 1XGOA 2BWVA 1YW7A 2Q95A 2GU6A 1Y1NA 1BOAA 3TB5A 2IW2A 2B3LA 3FMQA 2V3YA 4ZWUA 2GG3A 1XGNA 2GG2A 4ZNGA 2Q8KA 2V6CA 2GG9A 1W7VA 5CDLA 2EVOA 1KQ0A 2GGBA 4U71A 2Q96A 3PKAA 4U6ZA 1WLRA 4FLKA 2EA2A 3MR1A 2GG8A 3CB6A 4FLIA 2EVMA 5CDEA 2GG7A 2BHAA 4U1BA 1M35A 4R60A 4IKUA 2V3ZA 2NQ6A 1WN1A 4U69A 1QXWA 1B59A 4S2TP 1WBQA 2P9AA 2P98A 1BN5A 3CTZA 2V3XA 1R5HA 2BH3A 4RZZA 3PKBA 3PKDA 4IPAA 4MATA 1CHMA 1JAWA 2P99A 3IU9A 1R58A 2Q92A 4U6EA 2GU7A 2EA4A 2BN7A 4IKRA 1R5GA 1XGSA 1QZYA 2GU4A 4IKSA 4QR8A 1YW9A 4Z7MA 4IF7A 1YVMA 4IDYA 1KP0A 3L24A 4U76A 1C23A 5JHUA 4FLLA 1YW8A 1N51A 2GG0A 4RZYA 2DFIA 3IG4A 2OAZA 3MATA 5CNXA 2B3KA 2BWXA 5CDVA 4U6CA 4B28A 2B3HA 4KM3A 1XGMA 2GGCA 4ZWPA 4PV4A 5CIKA 2GG5A 3D27A 3FM3A 4HXXA 1A16A 5FCFA 2GTXA 2ZSGA 3BIPA 2BHCA 5CLSA 4RGZ1 2HOWA 3S6BA 2GA2A 2BB7A 2BWSA 3RORA 1B6AA 1C22A 1W2MA 2BWUA 4A6VA 5FCHA 4FKCA 4FO8A 4U70A 2BWTA 1O0XA 1QXZA 4U6JA 1WL6A 2Q93A 4EGEA 2BHDA 1WL9A 4U73A 5E5BA 1C27A 4FLJA 4IU6A 4OOKA 1XNZA 1PV9A 1C21A 1YJ3A 2EVCA 4FUKA 4IECA 4U6WA 2NQ7A 2GU5A 4S2RP 1WKMA 4JUQA 2BHBA 3BIQA 4S00A 3Q6DA 5JI6A 5D6EA 2G6PA 4ZWOA 4U75A 4S01A 1QXYA 2BWWA 1C24A 4PNCA 5D6FA
chains in the Genus database with same CATH superfamily
3PKCA 3MX6A 3IU8A 2Q94A 2MATA 1MATA 4A6WA 5CE6A 2BWYA 5JFRA 3L7GA 3IU7A 2ADUA 3PKEA 4IKTA 4FO7A 1WY2A 2GZ5A 3TAVA 3RVAA 1KQ9A 3FMRA 3CB5A 2OKNA 3BITA 1XGOA 2BWVA 1YW7A 2Q95A 2GU6A 1Y1NA 1BOAA 3TB5A 2IW2A 2B3LA 3FMQA 2V3YA 4ZWUA 2GG3A 1XGNA 2GG2A 4ZNGA 2Q8KA 2V6CA 2GG9A 1W7VA 5CDLA 2EVOA 1KQ0A 2GGBA 4U71A 2Q96A 3PKAA 4U6ZA 1WLRA 4FLKA 2EA2A 3MR1A 2GG8A 3CB6A 4FLIA 2EVMA 5CDEA 2GG7A 2BHAA 4U1BA 1M35A 4R60A 4IKUA 2V3ZA 2NQ6A 1WN1A 4U69A 1QXWA 1B59A 4S2TP 1WBQA 2P9AA 2P98A 1BN5A 3CTZA 2V3XA 1R5HA 2BH3A 4RZZA 3PKBA 3PKDA 4IPAA 4MATA 1CHMA 1JAWA 2P99A 3IU9A 1R58A 2Q92A 4U6EA 2GU7A 2EA4A 2BN7A 4IKRA 1R5GA 1XGSA 1QZYA 2GU4A 4IKSA 4QR8A 1YW9A 4Z7MA 4IF7A 1YVMA 4IDYA 1KP0A 3L24A 4U76A 1C23A 5JHUA 4FLLA 1YW8A 1N51A 2GG0A 4RZYA 2DFIA 3IG4A 2OAZA 3MATA 5CNXA 2B3KA 2BWXA 5CDVA 4U6CA 4B28A 2B3HA 4KM3A 1XGMA 2GGCA 4ZWPA 4PV4A 5CIKA 2GG5A 3D27A 3FM3A 4HXXA 1A16A 5FCFA 2GTXA 2ZSGA 3BIPA 2BHCA 5CLSA 4RGZ1 2HOWA 3S6BA 2GA2A 2BB7A 2BWSA 3RORA 1B6AA 1C22A 1W2MA 2BWUA 4A6VA 5FCHA 4FKCA 4FO8A 4U70A 2BWTA 1O0XA 1QXZA 4U6JA 1WL6A 2Q93A 4EGEA 2BHDA 1WL9A 4U73A 5E5BA 1C27A 4FLJA 4IU6A 4OOKA 1XNZA 1PV9A 1C21A 1YJ3A 2EVCA 4FUKA 4IECA 4U6WA 2NQ7A 2GU5A 4S2RP 1WKMA 4JUQA 2BHBA 3BIQA 4S00A 3Q6DA 5JI6A 5D6EA 2G6PA 4ZWOA 4U75A 4S01A 1QXYA 2BWWA 1C24A 4PNCA 5D6FA
chains in the Genus database with same CATH topology
3PKCA 3MX6A 3IU8A 2Q94A 2MATA 1MATA 4A6WA 5CE6A 2BWYA 5JFRA 3L7GA 3IU7A 2ADUA 3PKEA 4IKTA 4FO7A 1WY2A 2GZ5A 3TAVA 3RVAA 1KQ9A 3FMRA 3CB5A 2OKNA 3BITA 1XGOA 2BWVA 1YW7A 2Q95A 2GU6A 1Y1NA 1BOAA 3TB5A 2IW2A 2B3LA 3FMQA 2V3YA 4ZWUA 2GG3A 1XGNA 2GG2A 4ZNGA 2Q8KA 2V6CA 2GG9A 1W7VA 5CDLA 2EVOA 1KQ0A 2GGBA 4U71A 2Q96A 3PKAA 4U6ZA 1WLRA 4FLKA 2EA2A 3MR1A 2GG8A 3CB6A 4FLIA 2EVMA 5CDEA 2GG7A 2BHAA 4U1BA 1M35A 4R60A 4IKUA 2V3ZA 2NQ6A 1WN1A 4U69A 1QXWA 1B59A 4S2TP 1WBQA 2P9AA 2P98A 1BN5A 3CTZA 2V3XA 1R5HA 2BH3A 4RZZA 3PKBA 3PKDA 4IPAA 4MATA 1CHMA 1JAWA 2P99A 3IU9A 1R58A 2Q92A 4U6EA 2GU7A 2EA4A 2BN7A 4IKRA 1R5GA 1XGSA 1QZYA 2GU4A 4IKSA 4QR8A 1YW9A 4Z7MA 4IF7A 1YVMA 4IDYA 1KP0A 3L24A 4U76A 1C23A 5JHUA 4FLLA 1YW8A 1N51A 2GG0A 4RZYA 2DFIA 3IG4A 2OAZA 3MATA 5CNXA 2B3KA 2BWXA 5CDVA 4U6CA 4B28A 2B3HA 4KM3A 1XGMA 2GGCA 4ZWPA 4PV4A 5CIKA 2GG5A 3D27A 3FM3A 4HXXA 1A16A 5FCFA 2GTXA 2ZSGA 3BIPA 2BHCA 5CLSA 4RGZ1 2HOWA 3S6BA 2GA2A 2BB7A 2BWSA 3RORA 1B6AA 1C22A 1W2MA 2BWUA 4A6VA 5FCHA 4FKCA 4FO8A 4U70A 2BWTA 1O0XA 1QXZA 4U6JA 1WL6A 2Q93A 4EGEA 2BHDA 1WL9A 4U73A 5E5BA 1C27A 4FLJA 4IU6A 4OOKA 1XNZA 1PV9A 1C21A 1YJ3A 2EVCA 4FUKA 4IECA 4U6WA 2NQ7A 2GU5A 4S2RP 1WKMA 4JUQA 2BHBA 3BIQA 4S00A 3Q6DA 5JI6A 5D6EA 2G6PA 4ZWOA 4U75A 4S01A 1QXYA 2BWWA 1C24A 4PNCA 5D6FA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3PKC A;  3MX6 A;  3IU8 A;  2Q94 A;  2MAT A;  1MAT A;  4A6W A;  5CE6 A;  2BWY A;  5JFR A;  3L7G A;  3IU7 A;  2ADU A;  3PKE A;  4IKT A;  4FO7 A;  1WY2 A;  2GZ5 A;  3TAV A;  3RVA A;  1KQ9 A;  3FMR A;  3CB5 A;  2OKN A;  3BIT A;  1XGO A;  2BWV A;  1YW7 A;  2Q95 A;  2GU6 A;  1Y1N A;  1BOA A;  3TB5 A;  2IW2 A;  2B3L A;  3FMQ A;  2V3Y A;  4ZWU A;  2GG3 A;  1XGN A;  2GG2 A;  4ZNG A;  2Q8K A;  2V6C A;  2GG9 A;  1W7V A;  5CDL A;  2EVO A;  1KQ0 A;  2GGB A;  4U71 A;  2Q96 A;  3PKA A;  4U6Z A;  1WLR A;  4FLK A;  2EA2 A;  3MR1 A;  2GG8 A;  3CB6 A;  4FLI A;  2EVM A;  5CDE A;  2GG7 A;  2BHA A;  4U1B A;  1M35 A;  4R60 A;  4IKU A;  2V3Z A;  2NQ6 A;  1WN1 A;  4U69 A;  1QXW A;  1B59 A;  4S2T P;  1WBQ A;  2P9A A;  2P98 A;  1BN5 A;  3CTZ A;  2V3X A;  1R5H A;  2BH3 A;  4RZZ A;  3PKB A;  3PKD A;  4IPA A;  4MAT A;  1CHM A;  1JAW A;  2P99 A;  3IU9 A;  1R58 A;  2Q92 A;  4U6E A;  2GU7 A;  2EA4 A;  2BN7 A;  4IKR A;  1R5G A;  1XGS A;  1QZY A;  2GU4 A;  4IKS A;  4QR8 A;  1YW9 A;  4Z7M A;  4IF7 A;  1YVM A;  4IDY A;  1KP0 A;  3L24 A;  4U76 A;  1C23 A;  5JHU A;  4FLL A;  1YW8 A;  1N51 A;  2GG0 A;  4RZY A;  2DFI A;  3IG4 A;  2OAZ A;  3MAT A;  5CNX A;  2B3K A;  2BWX A;  5CDV A;  4U6C A;  4B28 A;  2B3H A;  4KM3 A;  1XGM A;  2GGC A;  4ZWP A;  4PV4 A;  5CIK A;  2GG5 A;  3D27 A;  3FM3 A;  4HXX A;  1A16 A;  5FCF A;  2GTX A;  2ZSG A;  3BIP A;  2BHC A;  5CLS A;  4RGZ 1;  2HOW A;  3S6B A;  2GA2 A;  2BB7 A;  2BWS A;  3ROR A;  1B6A A;  1C22 A;  1W2M A;  2BWU A;  4A6V A;  5FCH A;  4FKC A;  4FO8 A;  4U70 A;  2BWT A;  1O0X A;  1QXZ A;  4U6J A;  1WL6 A;  2Q93 A;  4EGE A;  2BHD A;  1WL9 A;  4U73 A;  5E5B A;  1C27 A;  4FLJ A;  4IU6 A;  4OOK A;  1XNZ A;  1PV9 A;  1C21 A;  1YJ3 A;  2EVC A;  4FUK A;  4IEC A;  4U6W A;  2NQ7 A;  2GU5 A;  4S2R P;  1WKM A;  4JUQ A;  2BHB A;  3BIQ A;  4S00 A;  3Q6D A;  5JI6 A;  5D6E A;  2G6P A;  4ZWO A;  4U75 A;  4S01 A;  1QXY A;  2BWW A;  1C24 A;  4PNC A;  5D6F A; 
#chains in the Genus database with same CATH topology
 3PKC A;  3MX6 A;  3IU8 A;  2Q94 A;  2MAT A;  1MAT A;  4A6W A;  5CE6 A;  2BWY A;  5JFR A;  3L7G A;  3IU7 A;  2ADU A;  3PKE A;  4IKT A;  4FO7 A;  1WY2 A;  2GZ5 A;  3TAV A;  3RVA A;  1KQ9 A;  3FMR A;  3CB5 A;  2OKN A;  3BIT A;  1XGO A;  2BWV A;  1YW7 A;  2Q95 A;  2GU6 A;  1Y1N A;  1BOA A;  3TB5 A;  2IW2 A;  2B3L A;  3FMQ A;  2V3Y A;  4ZWU A;  2GG3 A;  1XGN A;  2GG2 A;  4ZNG A;  2Q8K A;  2V6C A;  2GG9 A;  1W7V A;  5CDL A;  2EVO A;  1KQ0 A;  2GGB A;  4U71 A;  2Q96 A;  3PKA A;  4U6Z A;  1WLR A;  4FLK A;  2EA2 A;  3MR1 A;  2GG8 A;  3CB6 A;  4FLI A;  2EVM A;  5CDE A;  2GG7 A;  2BHA A;  4U1B A;  1M35 A;  4R60 A;  4IKU A;  2V3Z A;  2NQ6 A;  1WN1 A;  4U69 A;  1QXW A;  1B59 A;  4S2T P;  1WBQ A;  2P9A A;  2P98 A;  1BN5 A;  3CTZ A;  2V3X A;  1R5H A;  2BH3 A;  4RZZ A;  3PKB A;  3PKD A;  4IPA A;  4MAT A;  1CHM A;  1JAW A;  2P99 A;  3IU9 A;  1R58 A;  2Q92 A;  4U6E A;  2GU7 A;  2EA4 A;  2BN7 A;  4IKR A;  1R5G A;  1XGS A;  1QZY A;  2GU4 A;  4IKS A;  4QR8 A;  1YW9 A;  4Z7M A;  4IF7 A;  1YVM A;  4IDY A;  1KP0 A;  3L24 A;  4U76 A;  1C23 A;  5JHU A;  4FLL A;  1YW8 A;  1N51 A;  2GG0 A;  4RZY A;  2DFI A;  3IG4 A;  2OAZ A;  3MAT A;  5CNX A;  2B3K A;  2BWX A;  5CDV A;  4U6C A;  4B28 A;  2B3H A;  4KM3 A;  1XGM A;  2GGC A;  4ZWP A;  4PV4 A;  5CIK A;  2GG5 A;  3D27 A;  3FM3 A;  4HXX A;  1A16 A;  5FCF A;  2GTX A;  2ZSG A;  3BIP A;  2BHC A;  5CLS A;  4RGZ 1;  2HOW A;  3S6B A;  2GA2 A;  2BB7 A;  2BWS A;  3ROR A;  1B6A A;  1C22 A;  1W2M A;  2BWU A;  4A6V A;  5FCH A;  4FKC A;  4FO8 A;  4U70 A;  2BWT A;  1O0X A;  1QXZ A;  4U6J A;  1WL6 A;  2Q93 A;  4EGE A;  2BHD A;  1WL9 A;  4U73 A;  5E5B A;  1C27 A;  4FLJ A;  4IU6 A;  4OOK A;  1XNZ A;  1PV9 A;  1C21 A;  1YJ3 A;  2EVC A;  4FUK A;  4IEC A;  4U6W A;  2NQ7 A;  2GU5 A;  4S2R P;  1WKM A;  4JUQ A;  2BHB A;  3BIQ A;  4S00 A;  3Q6D A;  5JI6 A;  5D6E A;  2G6P A;  4ZWO A;  4U75 A;  4S01 A;  1QXY A;  2BWW A;  1C24 A;  4PNC A;  5D6F A; 
#chains in the Genus database with same CATH homology
 3PKC A;  3MX6 A;  3IU8 A;  2Q94 A;  2MAT A;  1MAT A;  4A6W A;  5CE6 A;  2BWY A;  5JFR A;  3L7G A;  3IU7 A;  2ADU A;  3PKE A;  4IKT A;  4FO7 A;  1WY2 A;  2GZ5 A;  3TAV A;  3RVA A;  1KQ9 A;  3FMR A;  3CB5 A;  2OKN A;  3BIT A;  1XGO A;  2BWV A;  1YW7 A;  2Q95 A;  2GU6 A;  1Y1N A;  1BOA A;  3TB5 A;  2IW2 A;  2B3L A;  3FMQ A;  2V3Y A;  4ZWU A;  2GG3 A;  1XGN A;  2GG2 A;  4ZNG A;  2Q8K A;  2V6C A;  2GG9 A;  1W7V A;  5CDL A;  2EVO A;  1KQ0 A;  2GGB A;  4U71 A;  2Q96 A;  3PKA A;  4U6Z A;  1WLR A;  4FLK A;  2EA2 A;  3MR1 A;  2GG8 A;  3CB6 A;  4FLI A;  2EVM A;  5CDE A;  2GG7 A;  2BHA A;  4U1B A;  1M35 A;  4R60 A;  4IKU A;  2V3Z A;  2NQ6 A;  1WN1 A;  4U69 A;  1QXW A;  1B59 A;  4S2T P;  1WBQ A;  2P9A A;  2P98 A;  1BN5 A;  3CTZ A;  2V3X A;  1R5H A;  2BH3 A;  4RZZ A;  3PKB A;  3PKD A;  4IPA A;  4MAT A;  1CHM A;  1JAW A;  2P99 A;  3IU9 A;  1R58 A;  2Q92 A;  4U6E A;  2GU7 A;  2EA4 A;  2BN7 A;  4IKR A;  1R5G A;  1XGS A;  1QZY A;  2GU4 A;  4IKS A;  4QR8 A;  1YW9 A;  4Z7M A;  4IF7 A;  1YVM A;  4IDY A;  1KP0 A;  3L24 A;  4U76 A;  1C23 A;  5JHU A;  4FLL A;  1YW8 A;  1N51 A;  2GG0 A;  4RZY A;  2DFI A;  3IG4 A;  2OAZ A;  3MAT A;  5CNX A;  2B3K A;  2BWX A;  5CDV A;  4U6C A;  4B28 A;  2B3H A;  4KM3 A;  1XGM A;  2GGC A;  4ZWP A;  4PV4 A;  5CIK A;  2GG5 A;  3D27 A;  3FM3 A;  4HXX A;  1A16 A;  5FCF A;  2GTX A;  2ZSG A;  3BIP A;  2BHC A;  5CLS A;  4RGZ 1;  2HOW A;  3S6B A;  2GA2 A;  2BB7 A;  2BWS A;  3ROR A;  1B6A A;  1C22 A;  1W2M A;  2BWU A;  4A6V A;  5FCH A;  4FKC A;  4FO8 A;  4U70 A;  2BWT A;  1O0X A;  1QXZ A;  4U6J A;  1WL6 A;  2Q93 A;  4EGE A;  2BHD A;  1WL9 A;  4U73 A;  5E5B A;  1C27 A;  4FLJ A;  4IU6 A;  4OOK A;  1XNZ A;  1PV9 A;  1C21 A;  1YJ3 A;  2EVC A;  4FUK A;  4IEC A;  4U6W A;  2NQ7 A;  2GU5 A;  4S2R P;  1WKM A;  4JUQ A;  2BHB A;  3BIQ A;  4S00 A;  3Q6D A;  5JI6 A;  5D6E A;  2G6P A;  4ZWO A;  4U75 A;  4S01 A;  1QXY A;  2BWW A;  1C24 A;  4PNC A;  5D6F A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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