4U75A

Hsmetap (f309m) in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u75A00
4JUQA 1YW7A 4RGZ1 2Q8KA 2GU7A 2MATA 1BOAA 2ZSGA 2B3KA 4ZWPA 3FM3A 2Q96A 5FCFA 2Q95A 3L24A 3PKEA 1N51A 4FUKA 4FLJA 5JFRA 2OAZA 4FLKA 2GZ5A 4KM3A 1WKMA 2GG2A 4U73A 4A6WA 1C22A 4FO7A 2BHAA 4U75A 4S2RP 4IDYA 2V3ZA 2GG3A 1JAWA 2GGCA 2Q94A 2IW2A 2BWWA 3CTZA 4U1BA 2G6PA 2V3YA 4FO8A 4RZZA 3PKCA 1QXYA 1KQ0A 2EVMA 4U6ZA 4ZNGA 2BWVA 1C27A 2BHDA 2NQ7A 3TB5A 4IPAA 3PKDA 4U71A 2BHBA 1XGMA 2GU5A 1XNZA 3BIPA 4U70A 2BHCA 2BWTA 1MATA 3BIQA 4U6JA 2BN7A 3D27A 3PKAA 2BWXA 1WY2A 1KP0A 1QXWA 2EA4A 2BWUA 1YJ3A 1WL6A 3IU8A 2GG8A 2GG9A 4IF7A 4U6CA 1C24A 4IKTA 1WLRA 4B28A 4OOKA 2BWYA 2BH3A 1YW8A 4U6WA 2GGBA 3MX6A 5CDEA 1B59A 4IU6A 5CDVA 1KQ9A 1XGSA 4ZWUA 5JHUA 1W2MA 5CLSA 2HOWA 2ADUA 4U6EA 3MR1A 1QZYA 2Q92A 4FKCA 4FLIA 4PNCA 3IU9A 5D6FA 5E5BA 4Z7MA 2GU6A 1C21A 2P98A 2NQ6A 4S00A 4U76A 3CB5A 4IKUA 2BB7A 1M35A 2Q93A 3RORA 2P9AA 1YW9A 2V6CA 4QR8A 5JI6A 3IG4A 1BN5A 1PV9A 2OKNA 1B6AA 4FLLA 4IKSA 5CDLA 4RZYA 2P99A 3IU7A 5FCHA 4IKRA 4A6VA 2GG7A 5CIKA 1WN1A 1C23A 1O0XA 3S6BA 1R58A 3L7GA 3CB6A 2GG0A 1YVMA 4HXXA 1Y1NA 3MATA 4S01A 3RVAA 3TAVA 2EVOA 2GG5A 3BITA 1WL9A 4PV4A 2EA2A 1QXZA 4U69A 1A16A 1R5GA 2GA2A 3Q6DA 1W7VA 1WBQA 2B3LA 2B3HA 2GU4A 1XGOA 1XGNA 1CHMA 2BWSA 4IECA 5D6EA 4ZWOA 3FMQA 2DFIA 4R60A 4EGEA 5CE6A 2EVCA 2V3XA 5CNXA 3PKBA 2GTXA 4MATA 4S2TP 1R5HA 3FMRA
chains in the Genus database with same CATH superfamily
4JUQA 1YW7A 4RGZ1 2Q8KA 2GU7A 2MATA 1BOAA 2ZSGA 2B3KA 4ZWPA 3FM3A 2Q96A 5FCFA 2Q95A 3L24A 3PKEA 1N51A 4FUKA 4FLJA 5JFRA 2OAZA 4FLKA 2GZ5A 4KM3A 1WKMA 2GG2A 4U73A 4A6WA 1C22A 4FO7A 2BHAA 4U75A 4S2RP 4IDYA 2V3ZA 2GG3A 1JAWA 2GGCA 2Q94A 2IW2A 2BWWA 3CTZA 4U1BA 2G6PA 2V3YA 4FO8A 4RZZA 3PKCA 1QXYA 1KQ0A 2EVMA 4U6ZA 4ZNGA 2BWVA 1C27A 2BHDA 2NQ7A 3TB5A 4IPAA 3PKDA 4U71A 2BHBA 1XGMA 2GU5A 1XNZA 3BIPA 4U70A 2BHCA 2BWTA 1MATA 3BIQA 4U6JA 2BN7A 3D27A 3PKAA 2BWXA 1WY2A 1KP0A 1QXWA 2EA4A 2BWUA 1YJ3A 1WL6A 3IU8A 2GG8A 2GG9A 4IF7A 4U6CA 1C24A 4IKTA 1WLRA 4B28A 4OOKA 2BWYA 2BH3A 1YW8A 4U6WA 2GGBA 3MX6A 5CDEA 1B59A 4IU6A 5CDVA 1KQ9A 1XGSA 4ZWUA 5JHUA 1W2MA 5CLSA 2HOWA 2ADUA 4U6EA 3MR1A 1QZYA 2Q92A 4FKCA 4FLIA 4PNCA 3IU9A 5D6FA 5E5BA 4Z7MA 2GU6A 1C21A 2P98A 2NQ6A 4S00A 4U76A 3CB5A 4IKUA 2BB7A 1M35A 2Q93A 3RORA 2P9AA 1YW9A 2V6CA 4QR8A 5JI6A 3IG4A 1BN5A 1PV9A 2OKNA 1B6AA 4FLLA 4IKSA 5CDLA 4RZYA 2P99A 3IU7A 5FCHA 4IKRA 4A6VA 2GG7A 5CIKA 1WN1A 1C23A 1O0XA 3S6BA 1R58A 3L7GA 3CB6A 2GG0A 1YVMA 4HXXA 1Y1NA 3MATA 4S01A 3RVAA 3TAVA 2EVOA 2GG5A 3BITA 1WL9A 4PV4A 2EA2A 1QXZA 4U69A 1A16A 1R5GA 2GA2A 3Q6DA 1W7VA 1WBQA 2B3LA 2B3HA 2GU4A 1XGOA 1XGNA 1CHMA 2BWSA 4IECA 5D6EA 4ZWOA 3FMQA 2DFIA 4R60A 4EGEA 5CE6A 2EVCA 2V3XA 5CNXA 3PKBA 2GTXA 4MATA 4S2TP 1R5HA 3FMRA
chains in the Genus database with same CATH topology
4JUQA 1YW7A 4RGZ1 2Q8KA 2GU7A 2MATA 1BOAA 2ZSGA 2B3KA 4ZWPA 3FM3A 2Q96A 5FCFA 2Q95A 3L24A 3PKEA 1N51A 4FUKA 4FLJA 5JFRA 2OAZA 4FLKA 2GZ5A 4KM3A 1WKMA 2GG2A 4U73A 4A6WA 1C22A 4FO7A 2BHAA 4U75A 4S2RP 4IDYA 2V3ZA 2GG3A 1JAWA 2GGCA 2Q94A 2IW2A 2BWWA 3CTZA 4U1BA 2G6PA 2V3YA 4FO8A 4RZZA 3PKCA 1QXYA 1KQ0A 2EVMA 4U6ZA 4ZNGA 2BWVA 1C27A 2BHDA 2NQ7A 3TB5A 4IPAA 3PKDA 4U71A 2BHBA 1XGMA 2GU5A 1XNZA 3BIPA 4U70A 2BHCA 2BWTA 1MATA 3BIQA 4U6JA 2BN7A 3D27A 3PKAA 2BWXA 1WY2A 1KP0A 1QXWA 2EA4A 2BWUA 1YJ3A 1WL6A 3IU8A 2GG8A 2GG9A 4IF7A 4U6CA 1C24A 4IKTA 1WLRA 4B28A 4OOKA 2BWYA 2BH3A 1YW8A 4U6WA 2GGBA 3MX6A 5CDEA 1B59A 4IU6A 5CDVA 1KQ9A 1XGSA 4ZWUA 5JHUA 1W2MA 5CLSA 2HOWA 2ADUA 4U6EA 3MR1A 1QZYA 2Q92A 4FKCA 4FLIA 4PNCA 3IU9A 5D6FA 5E5BA 4Z7MA 2GU6A 1C21A 2P98A 2NQ6A 4S00A 4U76A 3CB5A 4IKUA 2BB7A 1M35A 2Q93A 3RORA 2P9AA 1YW9A 2V6CA 4QR8A 5JI6A 3IG4A 1BN5A 1PV9A 2OKNA 1B6AA 4FLLA 4IKSA 5CDLA 4RZYA 2P99A 3IU7A 5FCHA 4IKRA 4A6VA 2GG7A 5CIKA 1WN1A 1C23A 1O0XA 3S6BA 1R58A 3L7GA 3CB6A 2GG0A 1YVMA 4HXXA 1Y1NA 3MATA 4S01A 3RVAA 3TAVA 2EVOA 2GG5A 3BITA 1WL9A 4PV4A 2EA2A 1QXZA 4U69A 1A16A 1R5GA 2GA2A 3Q6DA 1W7VA 1WBQA 2B3LA 2B3HA 2GU4A 1XGOA 1XGNA 1CHMA 2BWSA 4IECA 5D6EA 4ZWOA 3FMQA 2DFIA 4R60A 4EGEA 5CE6A 2EVCA 2V3XA 5CNXA 3PKBA 2GTXA 4MATA 4S2TP 1R5HA 3FMRA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4JUQ A;  1YW7 A;  4RGZ 1;  2Q8K A;  2GU7 A;  2MAT A;  1BOA A;  2ZSG A;  2B3K A;  4ZWP A;  3FM3 A;  2Q96 A;  5FCF A;  2Q95 A;  3L24 A;  3PKE A;  1N51 A;  4FUK A;  4FLJ A;  5JFR A;  2OAZ A;  4FLK A;  2GZ5 A;  4KM3 A;  1WKM A;  2GG2 A;  4U73 A;  4A6W A;  1C22 A;  4FO7 A;  2BHA A;  4U75 A;  4S2R P;  4IDY A;  2V3Z A;  2GG3 A;  1JAW A;  2GGC A;  2Q94 A;  2IW2 A;  2BWW A;  3CTZ A;  4U1B A;  2G6P A;  2V3Y A;  4FO8 A;  4RZZ A;  3PKC A;  1QXY A;  1KQ0 A;  2EVM A;  4U6Z A;  4ZNG A;  2BWV A;  1C27 A;  2BHD A;  2NQ7 A;  3TB5 A;  4IPA A;  3PKD A;  4U71 A;  2BHB A;  1XGM A;  2GU5 A;  1XNZ A;  3BIP A;  4U70 A;  2BHC A;  2BWT A;  1MAT A;  3BIQ A;  4U6J A;  2BN7 A;  3D27 A;  3PKA A;  2BWX A;  1WY2 A;  1KP0 A;  1QXW A;  2EA4 A;  2BWU A;  1YJ3 A;  1WL6 A;  3IU8 A;  2GG8 A;  2GG9 A;  4IF7 A;  4U6C A;  1C24 A;  4IKT A;  1WLR A;  4B28 A;  4OOK A;  2BWY A;  2BH3 A;  1YW8 A;  4U6W A;  2GGB A;  3MX6 A;  5CDE A;  1B59 A;  4IU6 A;  5CDV A;  1KQ9 A;  1XGS A;  4ZWU A;  5JHU A;  1W2M A;  5CLS A;  2HOW A;  2ADU A;  4U6E A;  3MR1 A;  1QZY A;  2Q92 A;  4FKC A;  4FLI A;  4PNC A;  3IU9 A;  5D6F A;  5E5B A;  4Z7M A;  2GU6 A;  1C21 A;  2P98 A;  2NQ6 A;  4S00 A;  4U76 A;  3CB5 A;  4IKU A;  2BB7 A;  1M35 A;  2Q93 A;  3ROR A;  2P9A A;  1YW9 A;  2V6C A;  4QR8 A;  5JI6 A;  3IG4 A;  1BN5 A;  1PV9 A;  2OKN A;  1B6A A;  4FLL A;  4IKS A;  5CDL A;  4RZY A;  2P99 A;  3IU7 A;  5FCH A;  4IKR A;  4A6V A;  2GG7 A;  5CIK A;  1WN1 A;  1C23 A;  1O0X A;  3S6B A;  1R58 A;  3L7G A;  3CB6 A;  2GG0 A;  1YVM A;  4HXX A;  1Y1N A;  3MAT A;  4S01 A;  3RVA A;  3TAV A;  2EVO A;  2GG5 A;  3BIT A;  1WL9 A;  4PV4 A;  2EA2 A;  1QXZ A;  4U69 A;  1A16 A;  1R5G A;  2GA2 A;  3Q6D A;  1W7V A;  1WBQ A;  2B3L A;  2B3H A;  2GU4 A;  1XGO A;  1XGN A;  1CHM A;  2BWS A;  4IEC A;  5D6E A;  4ZWO A;  3FMQ A;  2DFI A;  4R60 A;  4EGE A;  5CE6 A;  2EVC A;  2V3X A;  5CNX A;  3PKB A;  2GTX A;  4MAT A;  4S2T P;  1R5H A;  3FMR A; 
#chains in the Genus database with same CATH topology
 4JUQ A;  1YW7 A;  4RGZ 1;  2Q8K A;  2GU7 A;  2MAT A;  1BOA A;  2ZSG A;  2B3K A;  4ZWP A;  3FM3 A;  2Q96 A;  5FCF A;  2Q95 A;  3L24 A;  3PKE A;  1N51 A;  4FUK A;  4FLJ A;  5JFR A;  2OAZ A;  4FLK A;  2GZ5 A;  4KM3 A;  1WKM A;  2GG2 A;  4U73 A;  4A6W A;  1C22 A;  4FO7 A;  2BHA A;  4U75 A;  4S2R P;  4IDY A;  2V3Z A;  2GG3 A;  1JAW A;  2GGC A;  2Q94 A;  2IW2 A;  2BWW A;  3CTZ A;  4U1B A;  2G6P A;  2V3Y A;  4FO8 A;  4RZZ A;  3PKC A;  1QXY A;  1KQ0 A;  2EVM A;  4U6Z A;  4ZNG A;  2BWV A;  1C27 A;  2BHD A;  2NQ7 A;  3TB5 A;  4IPA A;  3PKD A;  4U71 A;  2BHB A;  1XGM A;  2GU5 A;  1XNZ A;  3BIP A;  4U70 A;  2BHC A;  2BWT A;  1MAT A;  3BIQ A;  4U6J A;  2BN7 A;  3D27 A;  3PKA A;  2BWX A;  1WY2 A;  1KP0 A;  1QXW A;  2EA4 A;  2BWU A;  1YJ3 A;  1WL6 A;  3IU8 A;  2GG8 A;  2GG9 A;  4IF7 A;  4U6C A;  1C24 A;  4IKT A;  1WLR A;  4B28 A;  4OOK A;  2BWY A;  2BH3 A;  1YW8 A;  4U6W A;  2GGB A;  3MX6 A;  5CDE A;  1B59 A;  4IU6 A;  5CDV A;  1KQ9 A;  1XGS A;  4ZWU A;  5JHU A;  1W2M A;  5CLS A;  2HOW A;  2ADU A;  4U6E A;  3MR1 A;  1QZY A;  2Q92 A;  4FKC A;  4FLI A;  4PNC A;  3IU9 A;  5D6F A;  5E5B A;  4Z7M A;  2GU6 A;  1C21 A;  2P98 A;  2NQ6 A;  4S00 A;  4U76 A;  3CB5 A;  4IKU A;  2BB7 A;  1M35 A;  2Q93 A;  3ROR A;  2P9A A;  1YW9 A;  2V6C A;  4QR8 A;  5JI6 A;  3IG4 A;  1BN5 A;  1PV9 A;  2OKN A;  1B6A A;  4FLL A;  4IKS A;  5CDL A;  4RZY A;  2P99 A;  3IU7 A;  5FCH A;  4IKR A;  4A6V A;  2GG7 A;  5CIK A;  1WN1 A;  1C23 A;  1O0X A;  3S6B A;  1R58 A;  3L7G A;  3CB6 A;  2GG0 A;  1YVM A;  4HXX A;  1Y1N A;  3MAT A;  4S01 A;  3RVA A;  3TAV A;  2EVO A;  2GG5 A;  3BIT A;  1WL9 A;  4PV4 A;  2EA2 A;  1QXZ A;  4U69 A;  1A16 A;  1R5G A;  2GA2 A;  3Q6D A;  1W7V A;  1WBQ A;  2B3L A;  2B3H A;  2GU4 A;  1XGO A;  1XGN A;  1CHM A;  2BWS A;  4IEC A;  5D6E A;  4ZWO A;  3FMQ A;  2DFI A;  4R60 A;  4EGE A;  5CE6 A;  2EVC A;  2V3X A;  5CNX A;  3PKB A;  2GTX A;  4MAT A;  4S2T P;  1R5H A;  3FMR A; 
#chains in the Genus database with same CATH homology
 4JUQ A;  1YW7 A;  4RGZ 1;  2Q8K A;  2GU7 A;  2MAT A;  1BOA A;  2ZSG A;  2B3K A;  4ZWP A;  3FM3 A;  2Q96 A;  5FCF A;  2Q95 A;  3L24 A;  3PKE A;  1N51 A;  4FUK A;  4FLJ A;  5JFR A;  2OAZ A;  4FLK A;  2GZ5 A;  4KM3 A;  1WKM A;  2GG2 A;  4U73 A;  4A6W A;  1C22 A;  4FO7 A;  2BHA A;  4U75 A;  4S2R P;  4IDY A;  2V3Z A;  2GG3 A;  1JAW A;  2GGC A;  2Q94 A;  2IW2 A;  2BWW A;  3CTZ A;  4U1B A;  2G6P A;  2V3Y A;  4FO8 A;  4RZZ A;  3PKC A;  1QXY A;  1KQ0 A;  2EVM A;  4U6Z A;  4ZNG A;  2BWV A;  1C27 A;  2BHD A;  2NQ7 A;  3TB5 A;  4IPA A;  3PKD A;  4U71 A;  2BHB A;  1XGM A;  2GU5 A;  1XNZ A;  3BIP A;  4U70 A;  2BHC A;  2BWT A;  1MAT A;  3BIQ A;  4U6J A;  2BN7 A;  3D27 A;  3PKA A;  2BWX A;  1WY2 A;  1KP0 A;  1QXW A;  2EA4 A;  2BWU A;  1YJ3 A;  1WL6 A;  3IU8 A;  2GG8 A;  2GG9 A;  4IF7 A;  4U6C A;  1C24 A;  4IKT A;  1WLR A;  4B28 A;  4OOK A;  2BWY A;  2BH3 A;  1YW8 A;  4U6W A;  2GGB A;  3MX6 A;  5CDE A;  1B59 A;  4IU6 A;  5CDV A;  1KQ9 A;  1XGS A;  4ZWU A;  5JHU A;  1W2M A;  5CLS A;  2HOW A;  2ADU A;  4U6E A;  3MR1 A;  1QZY A;  2Q92 A;  4FKC A;  4FLI A;  4PNC A;  3IU9 A;  5D6F A;  5E5B A;  4Z7M A;  2GU6 A;  1C21 A;  2P98 A;  2NQ6 A;  4S00 A;  4U76 A;  3CB5 A;  4IKU A;  2BB7 A;  1M35 A;  2Q93 A;  3ROR A;  2P9A A;  1YW9 A;  2V6C A;  4QR8 A;  5JI6 A;  3IG4 A;  1BN5 A;  1PV9 A;  2OKN A;  1B6A A;  4FLL A;  4IKS A;  5CDL A;  4RZY A;  2P99 A;  3IU7 A;  5FCH A;  4IKR A;  4A6V A;  2GG7 A;  5CIK A;  1WN1 A;  1C23 A;  1O0X A;  3S6B A;  1R58 A;  3L7G A;  3CB6 A;  2GG0 A;  1YVM A;  4HXX A;  1Y1N A;  3MAT A;  4S01 A;  3RVA A;  3TAV A;  2EVO A;  2GG5 A;  3BIT A;  1WL9 A;  4PV4 A;  2EA2 A;  1QXZ A;  4U69 A;  1A16 A;  1R5G A;  2GA2 A;  3Q6D A;  1W7V A;  1WBQ A;  2B3L A;  2B3H A;  2GU4 A;  1XGO A;  1XGN A;  1CHM A;  2BWS A;  4IEC A;  5D6E A;  4ZWO A;  3FMQ A;  2DFI A;  4R60 A;  4EGE A;  5CE6 A;  2EVC A;  2V3X A;  5CNX A;  3PKB A;  2GTX A;  4MAT A;  4S2T P;  1R5H A;  3FMR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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