1I4LA

Crystal structure analysis of rac1-gdp in complex with arfaptin (p41)
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
201
structure length
185
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 81
structure length 185
sequence length 201
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4lA00
2X3VA 2RAJA 1I4LA 1ZWWA 2X3WA 4WPCA 3SYVA 4ATMA 2EFKA 2D4CA 5C5BB 3PLTA 1I4DA 4NQIA 2FICA 1X04A 2Z0OA 3M3WA 4DYLA 2C08A 2Z0VA 2YKTA 5C5BA 4I1QA 1X03A 4NSWA 2Z0NA 3HAIA 3ACOA 1I49A 3SOGA 3HAJA 4DCNC 4AVMA 1I4TA 4AKVA 1URUA 3QE6A 2V0OA 3I2WA 2D1LA 4FZSA 3ABHA 3CAZA 4WPEA 2EFLA 3LLLA 1WDZA 2ELBA 3HAHA 3Q84A 3Q0KA 1Y2OA 3QWEA 3OK8A 4BNEA 2Q12A 2X3XA 4H8SA 2RAIA 3G9GA 3QNIA 2RAKA 3DYTA 2Q13A
chains in the Genus database with same CATH superfamily
1QWNA 2X3WA 3ER8C 2YIVX 4D8JA 1QWUA 3PLTA 3BUBA 1OAOA 3EJSA 2YI8A 4JWDA 4EZQA 1TQSA 3BLBA 3BVVA 3OK8A 4IM2A 2F7QA 2RAKA 4H6HA 3OHXM 4AZHA 4R5IA 3BUDA 2C08A 2Z0NA 2YIAA 4KIKB 2WINM 4IM0A 4AVMA 4EZYA 4WPEA 1WDZA 3HAHA 2Q12A 3RV1A 5C5BA 1GNTA 3DYTA 2X3VA 3DX0A 4FM3A 4HY9A 1U00A 1I4DA 1OA1A 2Z0VA 3HAIA 1TQUA 3L3PA 3D52A 4JWIA 3ABHA 4EZSA 2X3XA 2ND0A 3KAWA 3B52X 1SU7A 4DYLA 2YKTA 1SUFA 4AZGA 4R5LA 3FD9A 4EZPA 2GA9D 4IW0A 3I04A 3T46A 5FIGA 4UDYX 2YL5A 1X04A 4UDXX 2QXLA 1SU8A 1W9MA 2F18A 3QE6A 1TQVA 3BVUA 3Q84A 2OBLA 2F7OA 3B53X 1LQ7A 2YIBA 1HXKA 3SOGA 3BUQA 4DCNC 3CZNA 4R5JA 2YLLA 1UPXA 2F1AA 2O0I1 1R34A 2OBMA 2LXYA 3Q0KA 2Q13A 3EJPA 4AZIA 4WPCA 2F7RA 2FICA 4IWOA 2EWFA 3HAJA 3O3OB 4AZCA 2YL6A 4AKVA 2D1LA 4B9QA 1TQWA 2RT6A 3G9GA 3SYVA 4PO2A 1E9VA 3EJUA 3RPMA 1R5EA 4EZRA 2Z0OA 4JNFA 3D50A 4HYBA 3KAVA 2NCZA 3T47A 1OA0A 3ER9B 4IM3A 4AZ6A 3DDGA 2EX3B 3BVTA 1R33A 3DPOA 2RAIA 3EJTA 4FZPA 3F7WA 1I4LA 4HR1A 3VEAA 3CV5A 1O7DC 2OW6A 2YL9A 2PY6A 4EZWA 1GN9A 2F1BA 3T4AG 5TKYA 2V0OA 1YWMA 3I01A 2N3KA 2EFLA 4AZBA 1Y2OA 4R5KA 4BNEA 2OW7A 4E81A 2ZXQA 1E2UA 1ZWWA 3EJRA 3DPPA 2ND1A 3CVRA 3DX3A 4EZXA 4KIKA 4I1QA 3D51A 4JWCA 3BVWA 4JL9A 3A98A 4JLCA 3RV0A 4AZCB 3D4ZA 3UITA 4FZSA 3LMFA 3DDFA 2KHOA 4NPHA 3D4YA 3CKDA 2WYHA 4JN4A 4R5GA 1SU6A 2D4CA 5C5BB 4NSWA 3CZSA 4G6QA 3OWGA 1JQKA 4EZOA 2Z8YA 3VKHA 4H6IA 2GF4A 2F7PA 4JNEA 2YI9A 2MI7A 3ERCC 4HR1B 2OZNB 3BUIA 3DPQA 4JWEA 5KBPA 1MJGA 4EZVA 1E1DA 2LM0A 2OO2A 2PMRA 3LLLA 2X5CA 3T49A 3EJQA 3DX4A 3QNIA 2JNKA 2RAJA 1DKZA 2EFKA 3GI7A 1ZYLA 4AZ5A 3O3MB 4EZNA 3VEBA 3C7NA 4EZZA 4M0MA 1URUA 3DX2A 4EZUA 2QKWA 3BUPA 1PS3A 3CAZA 4H8SA 2ALWA 3KDRA 3QNJA 3M3WA 1HTYA 2QFFA 1X03A 3BVXA 4E3CA 4AZ7A 1TQTA 1O7DB 3ZEDA 1HWWA 2ELBA 4F00A 4ATMA 2FYVA 4NQIA 3T48A 3DX1A 2YL8A 3ACOA 4FZOA 2GAFD 2WYIA 4EZTA 3O3NB 1DKXA 3L3OM 3QWEA 1DKYA 1QX1A 1GNLA 4F01A 2JNSA 3D2EA 4IWQA 1I49A 5FLEX 1I4TA 2YLAA 3I39X 4IWPA 3B51X 3I2WA 3D2FA 5E84A 3QA8A 3LVTA
chains in the Genus database with same CATH topology
2X3VA 2RAJA 1I4LA 1ZWWA 2X3WA 4WPCA 3SYVA 4ATMA 2EFKA 2D4CA 5C5BB 3PLTA 1I4DA 4NQIA 2FICA 1X04A 2Z0OA 3M3WA 4DYLA 2C08A 2Z0VA 2YKTA 5C5BA 4I1QA 1X03A 4NSWA 2Z0NA 3HAIA 3ACOA 1I49A 3SOGA 3HAJA 4DCNC 4AVMA 1I4TA 4AKVA 1URUA 3QE6A 2V0OA 3I2WA 2D1LA 4FZSA 3ABHA 3CAZA 4WPEA 2EFLA 3LLLA 1WDZA 2ELBA 3HAHA 3Q84A 3Q0KA 1Y2OA 3QWEA 3OK8A 4BNEA 2Q12A 2X3XA 4H8SA 2RAIA 3G9GA 3QNIA 2RAKA 3DYTA 2Q13A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X3V A;  2RAJ A;  1I4L A;  1ZWW A;  2X3W A;  4WPC A;  3SYV A;  4ATM A;  2EFK A;  2D4C A;  5C5B B;  3PLT A;  1I4D A;  4NQI A;  2FIC A;  1X04 A;  2Z0O A;  3M3W A;  4DYL A;  2C08 A;  2Z0V A;  2YKT A;  5C5B A;  4I1Q A;  1X03 A;  4NSW A;  2Z0N A;  3HAI A;  3ACO A;  1I49 A;  3SOG A;  3HAJ A;  4DCN C;  4AVM A;  1I4T A;  4AKV A;  1URU A;  3QE6 A;  2V0O A;  3I2W A;  2D1L A;  4FZS A;  3ABH A;  3CAZ A;  4WPE A;  2EFL A;  3LLL A;  1WDZ A;  2ELB A;  3HAH A;  3Q84 A;  3Q0K A;  1Y2O A;  3QWE A;  3OK8 A;  4BNE A;  2Q12 A;  2X3X A;  4H8S A;  2RAI A;  3G9G A;  3QNI A;  2RAK A;  3DYT A;  2Q13 A; 
#chains in the Genus database with same CATH topology
 1QWN A;  2X3W A;  3ER8 C;  2YIV X;  4D8J A;  1QWU A;  3PLT A;  3BUB A;  1OAO A;  3EJS A;  2YI8 A;  4JWD A;  4EZQ A;  1TQS A;  3BLB A;  3BVV A;  3OK8 A;  4IM2 A;  2F7Q A;  2RAK A;  4H6H A;  3OHX M;  4AZH A;  4R5I A;  3BUD A;  2C08 A;  2Z0N A;  2YIA A;  4KIK B;  2WIN M;  4IM0 A;  4AVM A;  4EZY A;  4WPE A;  1WDZ A;  3HAH A;  2Q12 A;  3RV1 A;  5C5B A;  1GNT A;  3DYT A;  2X3V A;  3DX0 A;  4FM3 A;  4HY9 A;  1U00 A;  1I4D A;  1OA1 A;  2Z0V A;  3HAI A;  1TQU A;  3L3P A;  3D52 A;  4JWI A;  3ABH A;  4EZS A;  2X3X A;  2ND0 A;  3KAW A;  3B52 X;  1SU7 A;  4DYL A;  2YKT A;  1SUF A;  4AZG A;  4R5L A;  3FD9 A;  4EZP A;  2GA9 D;  4IW0 A;  3I04 A;  3T46 A;  5FIG A;  4UDY X;  2YL5 A;  1X04 A;  4UDX X;  2QXL A;  1SU8 A;  1W9M A;  2F18 A;  3QE6 A;  1TQV A;  3BVU A;  3Q84 A;  2OBL A;  2F7O A;  3B53 X;  1LQ7 A;  2YIB A;  1HXK A;  3SOG A;  3BUQ A;  4DCN C;  3CZN A;  4R5J A;  2YLL A;  1UPX A;  2F1A A;  2O0I 1;  1R34 A;  2OBM A;  2LXY A;  3Q0K A;  2Q13 A;  3EJP A;  4AZI A;  4WPC A;  2F7R A;  2FIC A;  4IWO A;  2EWF A;  3HAJ A;  3O3O B;  4AZC A;  2YL6 A;  4AKV A;  2D1L A;  4B9Q A;  1TQW A;  2RT6 A;  3G9G A;  3SYV A;  4PO2 A;  1E9V A;  3EJU A;  3RPM A;  1R5E A;  4EZR A;  2Z0O A;  4JNF A;  3D50 A;  4HYB A;  3KAV A;  2NCZ A;  3T47 A;  1OA0 A;  3ER9 B;  4IM3 A;  4AZ6 A;  3DDG A;  2EX3 B;  3BVT A;  1R33 A;  3DPO A;  2RAI A;  3EJT A;  4FZP A;  3F7W A;  1I4L A;  4HR1 A;  3VEA A;  3CV5 A;  1O7D C;  2OW6 A;  2YL9 A;  2PY6 A;  4EZW A;  1GN9 A;  2F1B A;  3T4A G;  5TKY A;  2V0O A;  1YWM A;  3I01 A;  2N3K A;  2EFL A;  4AZB A;  1Y2O A;  4R5K A;  4BNE A;  2OW7 A;  4E81 A;  2ZXQ A;  1E2U A;  1ZWW A;  3EJR A;  3DPP A;  2ND1 A;  3CVR A;  3DX3 A;  4EZX A;  4KIK A;  4I1Q A;  3D51 A;  4JWC A;  3BVW A;  4JL9 A;  3A98 A;  4JLC A;  3RV0 A;  4AZC B;  3D4Z A;  3UIT A;  4FZS A;  3LMF A;  3DDF A;  2KHO A;  4NPH A;  3D4Y A;  3CKD A;  2WYH A;  4JN4 A;  4R5G A;  1SU6 A;  2D4C A;  5C5B B;  4NSW A;  3CZS A;  4G6Q A;  3OWG A;  1JQK A;  4EZO A;  2Z8Y A;  3VKH A;  4H6I A;  2GF4 A;  2F7P A;  4JNE A;  2YI9 A;  2MI7 A;  3ERC C;  4HR1 B;  2OZN B;  3BUI A;  3DPQ A;  4JWE A;  5KBP A;  1MJG A;  4EZV A;  1E1D A;  2LM0 A;  2OO2 A;  2PMR A;  3LLL A;  2X5C A;  3T49 A;  3EJQ A;  3DX4 A;  3QNI A;  2JNK A;  2RAJ A;  1DKZ A;  2EFK A;  3GI7 A;  1ZYL A;  4AZ5 A;  3O3M B;  4EZN A;  3VEB A;  3C7N A;  4EZZ A;  4M0M A;  1URU A;  3DX2 A;  4EZU A;  2QKW A;  3BUP A;  1PS3 A;  3CAZ A;  4H8S A;  2ALW A;  3KDR A;  3QNJ A;  3M3W A;  1HTY A;  2QFF A;  1X03 A;  3BVX A;  4E3C A;  4AZ7 A;  1TQT A;  1O7D B;  3ZED A;  1HWW A;  2ELB A;  4F00 A;  4ATM A;  2FYV A;  4NQI A;  3T48 A;  3DX1 A;  2YL8 A;  3ACO A;  4FZO A;  2GAF D;  2WYI A;  4EZT A;  3O3N B;  1DKX A;  3L3O M;  3QWE A;  1DKY A;  1QX1 A;  1GNL A;  4F01 A;  2JNS A;  3D2E A;  4IWQ A;  1I49 A;  5FLE X;  1I4T A;  2YLA A;  3I39 X;  4IWP A;  3B51 X;  3I2W A;  3D2F A;  5E84 A;  3QA8 A;  3LVT A; 
#chains in the Genus database with same CATH homology
 2X3V A;  2RAJ A;  1I4L A;  1ZWW A;  2X3W A;  4WPC A;  3SYV A;  4ATM A;  2EFK A;  2D4C A;  5C5B B;  3PLT A;  1I4D A;  4NQI A;  2FIC A;  1X04 A;  2Z0O A;  3M3W A;  4DYL A;  2C08 A;  2Z0V A;  2YKT A;  5C5B A;  4I1Q A;  1X03 A;  4NSW A;  2Z0N A;  3HAI A;  3ACO A;  1I49 A;  3SOG A;  3HAJ A;  4DCN C;  4AVM A;  1I4T A;  4AKV A;  1URU A;  3QE6 A;  2V0O A;  3I2W A;  2D1L A;  4FZS A;  3ABH A;  3CAZ A;  4WPE A;  2EFL A;  3LLL A;  1WDZ A;  2ELB A;  3HAH A;  3Q84 A;  3Q0K A;  1Y2O A;  3QWE A;  3OK8 A;  4BNE A;  2Q12 A;  2X3X A;  4H8S A;  2RAI A;  3G9G A;  3QNI A;  2RAK A;  3DYT A;  2Q13 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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