1I4LA

Crystal structure analysis of rac1-gdp in complex with arfaptin (p41)
Total Genus 81
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
201
structure length
185
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 81
structure length 185
sequence length 201
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4lA00
1X04A 2C08A 3M3WA 4AVMA 1URUA 3HAIA 1I4TA 1ZWWA 2Z0OA 4NQIA 2D4CA 4DYLA 1I49A 4BNEA 2X3VA 2X3WA 2D1LA 4WPCA 2FICA 2Z0NA 2Z0VA 3ABHA 3DYTA 3Q0KA 4NSWA 1Y2OA 2EFLA 3QE6A 3CAZA 3Q84A 3HAJA 2EFKA 3QWEA 3SYVA 4ATMA 3SOGA 4AKVA 1I4DA 2RAKA 5C5BB 4H8SA 2X3XA 1X03A 3QNIA 1WDZA 5C5BA 2RAIA 3OK8A 2ELBA 2RAJA 2YKTA 2Q13A 3PLTA 4I1QA 4DCNC 3G9GA 3LLLA 2V0OA 1I4LA 2Q12A 3HAHA 4FZSA 3I2WA 3ACOA 4WPEA
chains in the Genus database with same CATH superfamily
4EZYA 4JL9A 4M0MA 3BUIA 2Z0NA 4H6HA 3QE6A 4IWPA 3BUQA 1LQ7A 4JWIA 4UDXX 1MJGA 3EJRA 2QKWA 3CZSA 2OO2A 4NQIA 2LXYA 3BUBA 3VKHA 2OW6A 3RV0A 4IW0A 3BLBA 2EFLA 4HYBA 1DKXA 3T4AG 4AZHA 1SU6A 4R5IA 3DDFA 2YLAA 3C7NA 4AVMA 3D4ZA 2EWFA 2YL9A 3O3NB 2QFFA 3A98A 1Y2OA 1OAOA 3BVWA 1QX1A 3KAVA 3KDRA 4IWQA 2V0OA 4IWOA 4EZTA 4JNEA 3I04A 4FZOA 2Z0OA 3DPOA 3D52A 2X3VA 2X3WA 1QWNA 1W9MA 3D2EA 2ND1A 4NSWA 2FYVA 3DYTA 3CV5A 3CZNA 1PS3A 3GI7A 3BVTA 3BVVA 3DX3A 2RT6A 3ZEDA 1ZYLA 1QWUA 1O7DB 2D4CA 3BUDA 3LMFA 4WPEA 4G6QA 3D50A 5C5BB 4AZ6A 4F01A 2PY6A 3UITA 2GF4A 4H6IA 3DX2A 5KBPA 4HY9A 2YL5A 3I01A 3M3WA 3CKDA 3RV1A 4EZUA 1GNLA 3VEBA 1DKYA 3Q0KA 2OBLA 4KIKA 2Q13A 2NCZA 1X04A 1I4TA 3DPPA 3D51A 3OHXM 2YI9A 4BNEA 2OBMA 3EJUA 2LM0A 1TQWA 5E84A 3EJQA 3O3MB 4DCNC 3O3OB 1I4LA 4R5KA 2ALWA 1ZWWA 3BUPA 4DYLA 4AZGA 4AZ5A 4ATMA 1R5EA 4EZNA 3Q84A 3HAJA 1E2UA 3FD9A 4R5GA 1R34A 4E81A 2X3XA 3QNIA 4EZRA 2GA9D 4R5JA 1TQTA 1R33A 3G9GA 3T47A 1YWMA 4AZIA 1SUFA 3KAWA 2F1AA 3B52X 4AZ7A 2ND0A 1HTYA 2GAFD 4HR1B 4IM3A 3DX1A 2WYIA 2JNKA 3D4YA 4JWEA 1GNTA 3I2WA 1DKZA 1TQUA 3B53X 5FIGA 4F00A 2OW7A 2D1LA 2FICA 2Z0VA 3BVXA 3SOGA 2F7OA 2YIVX 4NPHA 2YIBA 1O7DC 4EZPA 1WDZA 2RAIA 4HR1A 2RAJA 1UPXA 1TQSA 3LLLA 4FZSA 3HAHA 3ACOA 3D2FA 3CVRA 2WINM 3ER9B 2ZXQA 1I49A 2MI7A 3DX4A 1X03A 2X5CA 4IM2A 5C5BA 4AZBA 3QA8A 3F7WA 2JNSA 1E1DA 3L3PA 4FM3A 4JWCA 1JQKA 3QNJA 3BVUA 4WPCA 2F7RA 3QWEA 5FLEX 2EX3B 4AKVA 1OA0A 3OK8A 3ER8C 4D8JA 3PLTA 1SU7A 1HWWA 3OWGA 1OA1A 3T46A 4EZVA 3DX0A 1I4DA 5TKYA 4R5LA 4PO2A 3EJPA 2PMRA 2YKTA 3L3OM 2WYHA 3RPMA 2QXLA 4JNFA 4UDYX 3T48A 4JLCA 1U00A 1TQVA 1E9VA 2O0I1 2YL6A 2F1BA 2ELBA 2YLLA 2F18A 4B9QA 2C08A 4AZCB 3B51X 3HAIA 3T49A 2OZNB 3SYVA 3CAZA 2EFKA 3EJTA 4JWDA 4EZZA 1GN9A 4EZWA 2YIAA 3ERCC 4IM0A 3VEAA 2Z8YA 2N3KA 4EZQA 4I1QA 3DDGA 2YL8A 3LVTA 2YI8A 4EZSA 1URUA 1HXKA 4AZCA 4FZPA 4EZXA 4JN4A 4E3CA 3ABHA 3EJSA 2RAKA 2KHOA 4EZOA 1SU8A 4H8SA 4KIKB 2F7QA 2F7PA 3I39X 3DPQA 2Q12A
chains in the Genus database with same CATH topology
1X04A 2C08A 3M3WA 4AVMA 1URUA 3HAIA 1I4TA 1ZWWA 2Z0OA 4NQIA 2D4CA 4DYLA 1I49A 4BNEA 2X3VA 2X3WA 2D1LA 4WPCA 2FICA 2Z0NA 2Z0VA 3ABHA 3DYTA 3Q0KA 4NSWA 1Y2OA 2EFLA 3QE6A 3CAZA 3Q84A 3HAJA 2EFKA 3QWEA 3SYVA 4ATMA 3SOGA 4AKVA 1I4DA 2RAKA 5C5BB 4H8SA 2X3XA 1X03A 3QNIA 1WDZA 5C5BA 2RAIA 3OK8A 2ELBA 2RAJA 2YKTA 2Q13A 3PLTA 4I1QA 4DCNC 3G9GA 3LLLA 2V0OA 1I4LA 2Q12A 3HAHA 4FZSA 3I2WA 3ACOA 4WPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1X04 A;  2C08 A;  3M3W A;  4AVM A;  1URU A;  3HAI A;  1I4T A;  1ZWW A;  2Z0O A;  4NQI A;  2D4C A;  4DYL A;  1I49 A;  4BNE A;  2X3V A;  2X3W A;  2D1L A;  4WPC A;  2FIC A;  2Z0N A;  2Z0V A;  3ABH A;  3DYT A;  3Q0K A;  4NSW A;  1Y2O A;  2EFL A;  3QE6 A;  3CAZ A;  3Q84 A;  3HAJ A;  2EFK A;  3QWE A;  3SYV A;  4ATM A;  3SOG A;  4AKV A;  1I4D A;  2RAK A;  5C5B B;  4H8S A;  2X3X A;  1X03 A;  3QNI A;  1WDZ A;  5C5B A;  2RAI A;  3OK8 A;  2ELB A;  2RAJ A;  2YKT A;  2Q13 A;  3PLT A;  4I1Q A;  4DCN C;  3G9G A;  3LLL A;  2V0O A;  1I4L A;  2Q12 A;  3HAH A;  4FZS A;  3I2W A;  3ACO A;  4WPE A; 
#chains in the Genus database with same CATH topology
 4EZY A;  4JL9 A;  4M0M A;  3BUI A;  2Z0N A;  4H6H A;  3QE6 A;  4IWP A;  3BUQ A;  1LQ7 A;  4JWI A;  4UDX X;  1MJG A;  3EJR A;  2QKW A;  3CZS A;  2OO2 A;  4NQI A;  2LXY A;  3BUB A;  3VKH A;  2OW6 A;  3RV0 A;  4IW0 A;  3BLB A;  2EFL A;  4HYB A;  1DKX A;  3T4A G;  4AZH A;  1SU6 A;  4R5I A;  3DDF A;  2YLA A;  3C7N A;  4AVM A;  3D4Z A;  2EWF A;  2YL9 A;  3O3N B;  2QFF A;  3A98 A;  1Y2O A;  1OAO A;  3BVW A;  1QX1 A;  3KAV A;  3KDR A;  4IWQ A;  2V0O A;  4IWO A;  4EZT A;  4JNE A;  3I04 A;  4FZO A;  2Z0O A;  3DPO A;  3D52 A;  2X3V A;  2X3W A;  1QWN A;  1W9M A;  3D2E A;  2ND1 A;  4NSW A;  2FYV A;  3DYT A;  3CV5 A;  3CZN A;  1PS3 A;  3GI7 A;  3BVT A;  3BVV A;  3DX3 A;  2RT6 A;  3ZED A;  1ZYL A;  1QWU A;  1O7D B;  2D4C A;  3BUD A;  3LMF A;  4WPE A;  4G6Q A;  3D50 A;  5C5B B;  4AZ6 A;  4F01 A;  2PY6 A;  3UIT A;  2GF4 A;  4H6I A;  3DX2 A;  5KBP A;  4HY9 A;  2YL5 A;  3I01 A;  3M3W A;  3CKD A;  3RV1 A;  4EZU A;  1GNL A;  3VEB A;  1DKY A;  3Q0K A;  2OBL A;  4KIK A;  2Q13 A;  2NCZ A;  1X04 A;  1I4T A;  3DPP A;  3D51 A;  3OHX M;  2YI9 A;  4BNE A;  2OBM A;  3EJU A;  2LM0 A;  1TQW A;  5E84 A;  3EJQ A;  3O3M B;  4DCN C;  3O3O B;  1I4L A;  4R5K A;  2ALW A;  1ZWW A;  3BUP A;  4DYL A;  4AZG A;  4AZ5 A;  4ATM A;  1R5E A;  4EZN A;  3Q84 A;  3HAJ A;  1E2U A;  3FD9 A;  4R5G A;  1R34 A;  4E81 A;  2X3X A;  3QNI A;  4EZR A;  2GA9 D;  4R5J A;  1TQT A;  1R33 A;  3G9G A;  3T47 A;  1YWM A;  4AZI A;  1SUF A;  3KAW A;  2F1A A;  3B52 X;  4AZ7 A;  2ND0 A;  1HTY A;  2GAF D;  4HR1 B;  4IM3 A;  3DX1 A;  2WYI A;  2JNK A;  3D4Y A;  4JWE A;  1GNT A;  3I2W A;  1DKZ A;  1TQU A;  3B53 X;  5FIG A;  4F00 A;  2OW7 A;  2D1L A;  2FIC A;  2Z0V A;  3BVX A;  3SOG A;  2F7O A;  2YIV X;  4NPH A;  2YIB A;  1O7D C;  4EZP A;  1WDZ A;  2RAI A;  4HR1 A;  2RAJ A;  1UPX A;  1TQS A;  3LLL A;  4FZS A;  3HAH A;  3ACO A;  3D2F A;  3CVR A;  2WIN M;  3ER9 B;  2ZXQ A;  1I49 A;  2MI7 A;  3DX4 A;  1X03 A;  2X5C A;  4IM2 A;  5C5B A;  4AZB A;  3QA8 A;  3F7W A;  2JNS A;  1E1D A;  3L3P A;  4FM3 A;  4JWC A;  1JQK A;  3QNJ A;  3BVU A;  4WPC A;  2F7R A;  3QWE A;  5FLE X;  2EX3 B;  4AKV A;  1OA0 A;  3OK8 A;  3ER8 C;  4D8J A;  3PLT A;  1SU7 A;  1HWW A;  3OWG A;  1OA1 A;  3T46 A;  4EZV A;  3DX0 A;  1I4D A;  5TKY A;  4R5L A;  4PO2 A;  3EJP A;  2PMR A;  2YKT A;  3L3O M;  2WYH A;  3RPM A;  2QXL A;  4JNF A;  4UDY X;  3T48 A;  4JLC A;  1U00 A;  1TQV A;  1E9V A;  2O0I 1;  2YL6 A;  2F1B A;  2ELB A;  2YLL A;  2F18 A;  4B9Q A;  2C08 A;  4AZC B;  3B51 X;  3HAI A;  3T49 A;  2OZN B;  3SYV A;  3CAZ A;  2EFK A;  3EJT A;  4JWD A;  4EZZ A;  1GN9 A;  4EZW A;  2YIA A;  3ERC C;  4IM0 A;  3VEA A;  2Z8Y A;  2N3K A;  4EZQ A;  4I1Q A;  3DDG A;  2YL8 A;  3LVT A;  2YI8 A;  4EZS A;  1URU A;  1HXK A;  4AZC A;  4FZP A;  4EZX A;  4JN4 A;  4E3C A;  3ABH A;  3EJS A;  2RAK A;  2KHO A;  4EZO A;  1SU8 A;  4H8S A;  4KIK B;  2F7Q A;  2F7P A;  3I39 X;  3DPQ A;  2Q12 A; 
#chains in the Genus database with same CATH homology
 1X04 A;  2C08 A;  3M3W A;  4AVM A;  1URU A;  3HAI A;  1I4T A;  1ZWW A;  2Z0O A;  4NQI A;  2D4C A;  4DYL A;  1I49 A;  4BNE A;  2X3V A;  2X3W A;  2D1L A;  4WPC A;  2FIC A;  2Z0N A;  2Z0V A;  3ABH A;  3DYT A;  3Q0K A;  4NSW A;  1Y2O A;  2EFL A;  3QE6 A;  3CAZ A;  3Q84 A;  3HAJ A;  2EFK A;  3QWE A;  3SYV A;  4ATM A;  3SOG A;  4AKV A;  1I4D A;  2RAK A;  5C5B B;  4H8S A;  2X3X A;  1X03 A;  3QNI A;  1WDZ A;  5C5B A;  2RAI A;  3OK8 A;  2ELB A;  2RAJ A;  2YKT A;  2Q13 A;  3PLT A;  4I1Q A;  4DCN C;  3G9G A;  3LLL A;  2V0O A;  1I4L A;  2Q12 A;  3HAH A;  4FZS A;  3I2W A;  3ACO A;  4WPE A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...