1Y2OA

Structure of n-terminal domain irsp53/baiap2
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
248
structure length
248
Chain Sequence
MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords BAI1-associated protein 2 isoform 1
total genus 102
structure length 248
sequence length 248
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08397 IMD IRSp53/MIM homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1y2oA00
2X3WA 2EFLA 1X04A 4NQIA 5C5BB 3QWEA 3HAHA 1ZWWA 4WPEA 2EFKA 2RAJA 3ACOA 2FICA 1X03A 2RAIA 3M3WA 4BNEA 4DYLA 3G9GA 4DCNC 4FZSA 1WDZA 4WPCA 2Q12A 1I4LA 3QNIA 5C5BA 3QE6A 1URUA 3DYTA 4I1QA 2D1LA 2V0OA 3Q84A 4NSWA 4AKVA 3PLTA 3I2WA 1I4TA 3OK8A 3HAJA 4AVMA 2C08A 2X3VA 1I49A 1I4DA 3SYVA 2X3XA 2YKTA 2RAKA 2Q13A 3ABHA 3CAZA 2D4CA 3LLLA 4H8SA 2Z0VA 2Z0NA 3Q0KA 3HAIA 3SOGA 2Z0OA 4ATMA 1Y2OA 2ELBA
chains in the Genus database with same CATH superfamily
2EFLA 4AZCB 3DX3A 1ZWWA 3LVTA 2F7RA 4EZXA 3QE6A 4HR1B 2GA9D 1URUA 3DYTA 1YWMA 4PO2A 3T48A 2ALWA 3O3MB 3BVUA 4EZRA 3CAZA 2WYIA 3CZSA 1HXKA 1GNTA 3EJRA 4WPEA 3M3WA 2OW7A 1OA0A 3T4AG 2OW6A 4D8JA 4JWIA 3CZNA 4EZNA 2JNKA 3ABHA 3I04A 1QWNA 2ZXQA 5KBPA 2QKWA 2QFFA 1E2UA 4IM3A 3O3NB 3L3PA 4AZ6A 3OHXM 4AVMA 2C08A 1I49A 3BUBA 2FYVA 3LMFA 3DX0A 3ER8C 1DKXA 3B51X 4IWOA 4BNEA 1X03A 3KAWA 4FZOA 4JLCA 4EZYA 3D2EA 2PMRA 3VEBA 4IW0A 1SU6A 2X3VA 4UDYX 1JQKA 2F7PA 3CV5A 3Q0KA 3HAJA 1OAOA 2ND0A 3EJUA 3ZEDA 4JL9A 3BUPA 3ER9B 4FM3A 3DX4A 3Q84A 4HR1A 3DPPA 1TQTA 2F1AA 4EZPA 4JNEA 3LLLA 3HAIA 2Z0OA 1O7DB 1Y2OA 4ATMA 4IM0A 1R33A 2YL6A 2FICA 1R34A 4JN4A 5C5BA 3D50A 4KIKB 2EWFA 3KDRA 3VKHA 3VEAA 3DPQA 1E1DA 3T46A 3RV1A 4EZWA 1SUFA 1TQUA 2RAJA 3C7NA 4M0MA 1SU8A 3BUIA 1PS3A 1ZYLA 4R5IA 1DKZA 4B9QA 2GF4A 3OK8A 2JNSA 2QXLA 3I01A 4G6QA 3DX1A 3QNIA 2WYHA 2F7QA 3BVXA 3D4YA 3BUQA 3B52X 4AZIA 1I4DA 2MI7A 3BVWA 2YLLA 4IWPA 4H8SA 4R5JA 4EZUA 1MJGA 3BLBA 4JNFA 4AZGA 3D2FA 1DKYA 1R5EA 2YIBA 1QWUA 3I2WA 4JWEA 2YL5A 2RAKA 3T49A 2YIAA 1QX1A 2EX3B 3D4ZA 2F18A 2KHOA 4DCNC 4AZCA 4WPCA 3EJQA 2YL9A 4H6HA 2PY6A 2Z8YA 3D52A 3D51A 1I4TA 4UDXX 2NCZA 2Z0NA 1SU7A 2RT6A 4F00A 2YIVX 3F7WA 3BVTA 3O3OB 2YLAA 3EJTA 2LM0A 3GI7A 2Z0VA 4AZHA 2RAIA 4DYLA 2YI8A 2OO2A 4I1QA 3FD9A 4EZTA 4EZZA 4JWDA 4AKVA 2N3KA 1TQVA 3DDFA 3DDGA 4EZQA 2YKTA 2F1BA 2Q13A 3EJSA 2OZNB 1OA1A 3L3OM 5C5BB 4R5KA 2LXYA 4R5LA 3A98A 2D1LA 2V0OA 4H6IA 4NSWA 4IM2A 2YL8A 3SYVA 3CVRA 1HWWA 4EZSA 3BVVA 3QA8A 3SOGA 2ELBA 5TKYA 2GAFD 3HAHA 4FZPA 3G9GA 4E81A 4FZSA 1TQWA 3PLTA 3T47A 2ND1A 1LQ7A 2X5CA 2X3XA 2OBMA 4E3CA 1W9MA 4JWCA 1HTYA 2WINM 4EZOA 1X04A 3B53X 3BUDA 4NQIA 3OWGA 3QWEA 2EFKA 3RV0A 1WDZA 3CKDA 2Q12A 1I4LA 4R5GA 3KAVA 4AZ7A 5E84A 3EJPA 4KIKA 3UITA 1U00A 1GN9A 1E9VA 5FIGA 2X3WA 3DPOA 3ACOA 3ERCC 4NPHA 3DX2A 1GNLA 4AZ5A 3I39X 2F7OA 4IWQA 5FLEX 4F01A 3QNJA 1O7DC 4EZVA 2YI9A 1UPXA 2OBLA 3RPMA 4HYBA 4HY9A 2O0I1 1TQSA 4AZBA 2D4CA
chains in the Genus database with same CATH topology
2X3WA 2EFLA 1X04A 4NQIA 5C5BB 3QWEA 3HAHA 1ZWWA 4WPEA 2EFKA 2RAJA 3ACOA 2FICA 1X03A 2RAIA 3M3WA 4BNEA 4DYLA 3G9GA 4DCNC 4FZSA 1WDZA 4WPCA 2Q12A 1I4LA 3QNIA 5C5BA 3QE6A 1URUA 3DYTA 4I1QA 2D1LA 2V0OA 3Q84A 4NSWA 4AKVA 3PLTA 3I2WA 1I4TA 3OK8A 3HAJA 4AVMA 2C08A 2X3VA 1I49A 1I4DA 3SYVA 2X3XA 2YKTA 2RAKA 2Q13A 3ABHA 3CAZA 2D4CA 3LLLA 4H8SA 2Z0VA 2Z0NA 3Q0KA 3HAIA 3SOGA 2Z0OA 4ATMA 1Y2OA 2ELBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X3W A;  2EFL A;  1X04 A;  4NQI A;  5C5B B;  3QWE A;  3HAH A;  1ZWW A;  4WPE A;  2EFK A;  2RAJ A;  3ACO A;  2FIC A;  1X03 A;  2RAI A;  3M3W A;  4BNE A;  4DYL A;  3G9G A;  4DCN C;  4FZS A;  1WDZ A;  4WPC A;  2Q12 A;  1I4L A;  3QNI A;  5C5B A;  3QE6 A;  1URU A;  3DYT A;  4I1Q A;  2D1L A;  2V0O A;  3Q84 A;  4NSW A;  4AKV A;  3PLT A;  3I2W A;  1I4T A;  3OK8 A;  3HAJ A;  4AVM A;  2C08 A;  2X3V A;  1I49 A;  1I4D A;  3SYV A;  2X3X A;  2YKT A;  2RAK A;  2Q13 A;  3ABH A;  3CAZ A;  2D4C A;  3LLL A;  4H8S A;  2Z0V A;  2Z0N A;  3Q0K A;  3HAI A;  3SOG A;  2Z0O A;  4ATM A;  1Y2O A;  2ELB A; 
#chains in the Genus database with same CATH topology
 2EFL A;  4AZC B;  3DX3 A;  1ZWW A;  3LVT A;  2F7R A;  4EZX A;  3QE6 A;  4HR1 B;  2GA9 D;  1URU A;  3DYT A;  1YWM A;  4PO2 A;  3T48 A;  2ALW A;  3O3M B;  3BVU A;  4EZR A;  3CAZ A;  2WYI A;  3CZS A;  1HXK A;  1GNT A;  3EJR A;  4WPE A;  3M3W A;  2OW7 A;  1OA0 A;  3T4A G;  2OW6 A;  4D8J A;  4JWI A;  3CZN A;  4EZN A;  2JNK A;  3ABH A;  3I04 A;  1QWN A;  2ZXQ A;  5KBP A;  2QKW A;  2QFF A;  1E2U A;  4IM3 A;  3O3N B;  3L3P A;  4AZ6 A;  3OHX M;  4AVM A;  2C08 A;  1I49 A;  3BUB A;  2FYV A;  3LMF A;  3DX0 A;  3ER8 C;  1DKX A;  3B51 X;  4IWO A;  4BNE A;  1X03 A;  3KAW A;  4FZO A;  4JLC A;  4EZY A;  3D2E A;  2PMR A;  3VEB A;  4IW0 A;  1SU6 A;  2X3V A;  4UDY X;  1JQK A;  2F7P A;  3CV5 A;  3Q0K A;  3HAJ A;  1OAO A;  2ND0 A;  3EJU A;  3ZED A;  4JL9 A;  3BUP A;  3ER9 B;  4FM3 A;  3DX4 A;  3Q84 A;  4HR1 A;  3DPP A;  1TQT A;  2F1A A;  4EZP A;  4JNE A;  3LLL A;  3HAI A;  2Z0O A;  1O7D B;  1Y2O A;  4ATM A;  4IM0 A;  1R33 A;  2YL6 A;  2FIC A;  1R34 A;  4JN4 A;  5C5B A;  3D50 A;  4KIK B;  2EWF A;  3KDR A;  3VKH A;  3VEA A;  3DPQ A;  1E1D A;  3T46 A;  3RV1 A;  4EZW A;  1SUF A;  1TQU A;  2RAJ A;  3C7N A;  4M0M A;  1SU8 A;  3BUI A;  1PS3 A;  1ZYL A;  4R5I A;  1DKZ A;  4B9Q A;  2GF4 A;  3OK8 A;  2JNS A;  2QXL A;  3I01 A;  4G6Q A;  3DX1 A;  3QNI A;  2WYH A;  2F7Q A;  3BVX A;  3D4Y A;  3BUQ A;  3B52 X;  4AZI A;  1I4D A;  2MI7 A;  3BVW A;  2YLL A;  4IWP A;  4H8S A;  4R5J A;  4EZU A;  1MJG A;  3BLB A;  4JNF A;  4AZG A;  3D2F A;  1DKY A;  1R5E A;  2YIB A;  1QWU A;  3I2W A;  4JWE A;  2YL5 A;  2RAK A;  3T49 A;  2YIA A;  1QX1 A;  2EX3 B;  3D4Z A;  2F18 A;  2KHO A;  4DCN C;  4AZC A;  4WPC A;  3EJQ A;  2YL9 A;  4H6H A;  2PY6 A;  2Z8Y A;  3D52 A;  3D51 A;  1I4T A;  4UDX X;  2NCZ A;  2Z0N A;  1SU7 A;  2RT6 A;  4F00 A;  2YIV X;  3F7W A;  3BVT A;  3O3O B;  2YLA A;  3EJT A;  2LM0 A;  3GI7 A;  2Z0V A;  4AZH A;  2RAI A;  4DYL A;  2YI8 A;  2OO2 A;  4I1Q A;  3FD9 A;  4EZT A;  4EZZ A;  4JWD A;  4AKV A;  2N3K A;  1TQV A;  3DDF A;  3DDG A;  4EZQ A;  2YKT A;  2F1B A;  2Q13 A;  3EJS A;  2OZN B;  1OA1 A;  3L3O M;  5C5B B;  4R5K A;  2LXY A;  4R5L A;  3A98 A;  2D1L A;  2V0O A;  4H6I A;  4NSW A;  4IM2 A;  2YL8 A;  3SYV A;  3CVR A;  1HWW A;  4EZS A;  3BVV A;  3QA8 A;  3SOG A;  2ELB A;  5TKY A;  2GAF D;  3HAH A;  4FZP A;  3G9G A;  4E81 A;  4FZS A;  1TQW A;  3PLT A;  3T47 A;  2ND1 A;  1LQ7 A;  2X5C A;  2X3X A;  2OBM A;  4E3C A;  1W9M A;  4JWC A;  1HTY A;  2WIN M;  4EZO A;  1X04 A;  3B53 X;  3BUD A;  4NQI A;  3OWG A;  3QWE A;  2EFK A;  3RV0 A;  1WDZ A;  3CKD A;  2Q12 A;  1I4L A;  4R5G A;  3KAV A;  4AZ7 A;  5E84 A;  3EJP A;  4KIK A;  3UIT A;  1U00 A;  1GN9 A;  1E9V A;  5FIG A;  2X3W A;  3DPO A;  3ACO A;  3ERC C;  4NPH A;  3DX2 A;  1GNL A;  4AZ5 A;  3I39 X;  2F7O A;  4IWQ A;  5FLE X;  4F01 A;  3QNJ A;  1O7D C;  4EZV A;  2YI9 A;  1UPX A;  2OBL A;  3RPM A;  4HYB A;  4HY9 A;  2O0I 1;  1TQS A;  4AZB A;  2D4C A; 
#chains in the Genus database with same CATH homology
 2X3W A;  2EFL A;  1X04 A;  4NQI A;  5C5B B;  3QWE A;  3HAH A;  1ZWW A;  4WPE A;  2EFK A;  2RAJ A;  3ACO A;  2FIC A;  1X03 A;  2RAI A;  3M3W A;  4BNE A;  4DYL A;  3G9G A;  4DCN C;  4FZS A;  1WDZ A;  4WPC A;  2Q12 A;  1I4L A;  3QNI A;  5C5B A;  3QE6 A;  1URU A;  3DYT A;  4I1Q A;  2D1L A;  2V0O A;  3Q84 A;  4NSW A;  4AKV A;  3PLT A;  3I2W A;  1I4T A;  3OK8 A;  3HAJ A;  4AVM A;  2C08 A;  2X3V A;  1I49 A;  1I4D A;  3SYV A;  2X3X A;  2YKT A;  2RAK A;  2Q13 A;  3ABH A;  3CAZ A;  2D4C A;  3LLL A;  4H8S A;  2Z0V A;  2Z0N A;  3Q0K A;  3HAI A;  3SOG A;  2Z0O A;  4ATM A;  1Y2O A;  2ELB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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