1O7DB

The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low ph activation
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
75
structure length
75
Chain Sequence
IRVNVLYSTPACYLWELNKANLSWSVKKDDFFPYADGPYMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALAGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Lysosomal alpha-mannosidase
total genus 15
structure length 75
sequence length 75
ec nomenclature ec 3.2.1.24: Alpha-mannosidase.
pdb deposition date 2002-10-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.50 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Glycoside hydrolase family 38, central domain 1o7dB00
3DX0A 1HXKA 3DDGA 3CZSA 3EJTA 3D4YA 1TQVA 2F7RA 3CV5A 3D52A 1O7DB 1QWNA 2WYIA 3BUQA 2F7PA 3BUBA 2F7OA 1QWUA 2WYHA 3EJPA 3CZNA 1TQSA 3BVWA 1PS3A 1QX1A 1TQUA 3D51A 3DX1A 3EJRA 1R33A 2ALWA 3D4ZA 3D50A 2F1BA 3BUPA 3DX4A 1TQWA 2F7QA 1HTYA 3BUDA 3DX2A 3EJSA 2F1AA 1HWWA 3EJUA 3DDFA 1R34A 3EJQA 2F18A 3BVTA 3BLBA 1TQTA 3BVXA 2OW7A 3LVTA 3BVUA 3BVVA 5KBPA 1O7DC 3DX3A 3BUIA 2FYVA 2OW6A
chains in the Genus database with same CATH superfamily
4AZGA 4AZIA 2ELBA 4JN4A 1SU7A 2LXYA 2YL9A 3T48A 3RV0A 3B52X 3EJSA 1DKXA 3VEAA 4FZPA 3T4AG 3LVTA 3VEBA 4EZXA 4HR1A 1SU8A 4AZCA 2MI7A 2ZXQA 4DCNC 2YL5A 3L3OM 4EZSA 3KDRA 2JNSA 4FZSA 1R5EA 2V0OA 1O7DC 2ND0A 2FICA 2YLLA 4EZZA 3D2FA 3ER8C 2EFLA 1OAOA 2F7PA 2YIAA 1TQUA 2X5CA 2F1BA 4EZWA 1OA1A 3DX2A 4H8SA 3BLBA 2OW7A 2X3VA 2Z8YA 5E84A 2C08A 5C5BB 4E3CA 1SU6A 3RV1A 2RAJA 3LLLA 4IM2A 3BUQA 2YKTA 4JWEA 5TKYA 4NQIA 3ER9B 2ALWA 3B53X 2WINM 1I4TA 2Z0NA 3DDFA 3FD9A 4F00A 3BVUA 1GN9A 4HY9A 4AZHA 3Q84A 3DDGA 3CZSA 2YLAA 2Q13A 1URUA 1U00A 2OZNB 2OBMA 3I2WA 3DPOA 4E81A 4HYBA 2LM0A 3SYVA 2QKWA 4H6HA 4NSWA 1R33A 3ERCC 3M3WA 3DPPA 3EJUA 2YIVX 1MJGA 4HR1B 3DX3A 4M0MA 3DYTA 2OW6A 1LQ7A 3CV5A 1QWNA 2D4CA 2OBLA 2OO2A 3BVWA 3HAHA 4EZQA 3O3MB 3D2EA 1WDZA 4ATMA 1I4LA 3BVTA 3ACOA 3BVXA 4JWCA 2Q12A 3T46A 4EZTA 2FYVA 1I4DA 2EX3B 2WYIA 3QNJA 4AKVA 1QWUA 2PMRA 3EJPA 4FZOA 4EZUA 4EZPA 4R5KA 2EWFA 2JNKA 3GI7A 3O3OB 3G9GA 2YL8A 1HWWA 2F18A 1E9VA 4UDXX 4EZVA 4D8JA 1I49A 3ZEDA 3Q0KA 1HXKA 3D4YA 1TQVA 2F7RA 1O7DB 1GNTA 2PY6A 1YWMA 1TQWA 4FM3A 4R5JA 3L3PA 2F7QA 3PLTA 4R5LA 4IM0A 1X03A 1TQTA 4JLCA 4IM3A 3UITA 4EZYA 4JNFA 5C5BA 2RAIA 4KIKA 4R5GA 4IW0A 2NCZA 4WPEA 3D51A 3DX1A 3D4ZA 1Y2OA 2GAFD 3KAWA 1HTYA 4AZBA 2GF4A 1R34A 1UPXA 3BUIA 4F01A 1OA0A 3EJTA 3F7WA 3VKHA 2WYHA 4NPHA 3CZNA 2X3WA 3HAIA 4I1QA 3D50A 3T47A 2YI9A 4JNEA 2QXLA 3T49A 5FLEX 3OHXM 2N3KA 2EFKA 3BVVA 4EZRA 5KBPA 1E1DA 3HAJA 2D1LA 3QNIA 3CKDA 4IWOA 1GNLA 4B9QA 3D52A 2F7OA 4AZCB 3QWEA 1PS3A 2Z0OA 4JWDA 3RPMA 4R5IA 1DKZA 2QFFA 2F1AA 1ZWWA 2RAKA 2KHOA 3OWGA 3O3NB 4EZOA 1TQSA 2O0I1 1QX1A 4WPCA 2YIBA 3EJRA 3BUPA 3DPQA 4AZ5A 2YL6A 4PO2A 5FIGA 3CVRA 3EJQA 1W9MA 4DYLA 4JWIA 4EZNA 1ZYLA 4G6QA 2Z0VA 4AVMA 3I01A 1JQKA 2GA9D 3SOGA 3KAVA 3QE6A 3DX4A 3C7NA 1E2UA 3BUDA 4BNEA 1SUFA 2ND1A 3LMFA 4AZ6A 4KIKB 3DX0A 3ABHA 2YI8A 3B51X 3BUBA 3OK8A 4IWQA 1DKYA 3A98A 4JL9A 3CAZA 3I39X 2X3XA 1X04A 2RT6A 3I04A 4IWPA 4UDYX 4AZ7A 4H6IA 3QA8A
chains in the Genus database with same CATH topology
3DX0A 1HXKA 3DDGA 3CZSA 3EJTA 3D4YA 1TQVA 2F7RA 3CV5A 3D52A 1O7DB 1QWNA 2WYIA 3BUQA 2F7PA 3BUBA 2F7OA 1QWUA 2WYHA 3EJPA 3CZNA 1TQSA 3BVWA 1PS3A 1QX1A 1TQUA 3D51A 3DX1A 3EJRA 1R33A 2ALWA 3D4ZA 3D50A 2F1BA 3BUPA 3DX4A 1TQWA 2F7QA 1HTYA 3BUDA 3DX2A 3EJSA 2F1AA 1HWWA 3EJUA 3DDFA 1R34A 3EJQA 2F18A 3BVTA 3BLBA 1TQTA 3BVXA 2OW7A 3LVTA 3BVUA 3BVVA 5KBPA 1O7DC 3DX3A 3BUIA 2FYVA 2OW6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DX0 A;  1HXK A;  3DDG A;  3CZS A;  3EJT A;  3D4Y A;  1TQV A;  2F7R A;  3CV5 A;  3D52 A;  1O7D B;  1QWN A;  2WYI A;  3BUQ A;  2F7P A;  3BUB A;  2F7O A;  1QWU A;  2WYH A;  3EJP A;  3CZN A;  1TQS A;  3BVW A;  1PS3 A;  1QX1 A;  1TQU A;  3D51 A;  3DX1 A;  3EJR A;  1R33 A;  2ALW A;  3D4Z A;  3D50 A;  2F1B A;  3BUP A;  3DX4 A;  1TQW A;  2F7Q A;  1HTY A;  3BUD A;  3DX2 A;  3EJS A;  2F1A A;  1HWW A;  3EJU A;  3DDF A;  1R34 A;  3EJQ A;  2F18 A;  3BVT A;  3BLB A;  1TQT A;  3BVX A;  2OW7 A;  3LVT A;  3BVU A;  3BVV A;  5KBP A;  1O7D C;  3DX3 A;  3BUI A;  2FYV A;  2OW6 A; 
#chains in the Genus database with same CATH topology
 4AZG A;  4AZI A;  2ELB A;  4JN4 A;  1SU7 A;  2LXY A;  2YL9 A;  3T48 A;  3RV0 A;  3B52 X;  3EJS A;  1DKX A;  3VEA A;  4FZP A;  3T4A G;  3LVT A;  3VEB A;  4EZX A;  4HR1 A;  1SU8 A;  4AZC A;  2MI7 A;  2ZXQ A;  4DCN C;  2YL5 A;  3L3O M;  4EZS A;  3KDR A;  2JNS A;  4FZS A;  1R5E A;  2V0O A;  1O7D C;  2ND0 A;  2FIC A;  2YLL A;  4EZZ A;  3D2F A;  3ER8 C;  2EFL A;  1OAO A;  2F7P A;  2YIA A;  1TQU A;  2X5C A;  2F1B A;  4EZW A;  1OA1 A;  3DX2 A;  4H8S A;  3BLB A;  2OW7 A;  2X3V A;  2Z8Y A;  5E84 A;  2C08 A;  5C5B B;  4E3C A;  1SU6 A;  3RV1 A;  2RAJ A;  3LLL A;  4IM2 A;  3BUQ A;  2YKT A;  4JWE A;  5TKY A;  4NQI A;  3ER9 B;  2ALW A;  3B53 X;  2WIN M;  1I4T A;  2Z0N A;  3DDF A;  3FD9 A;  4F00 A;  3BVU A;  1GN9 A;  4HY9 A;  4AZH A;  3Q84 A;  3DDG A;  3CZS A;  2YLA A;  2Q13 A;  1URU A;  1U00 A;  2OZN B;  2OBM A;  3I2W A;  3DPO A;  4E81 A;  4HYB A;  2LM0 A;  3SYV A;  2QKW A;  4H6H A;  4NSW A;  1R33 A;  3ERC C;  3M3W A;  3DPP A;  3EJU A;  2YIV X;  1MJG A;  4HR1 B;  3DX3 A;  4M0M A;  3DYT A;  2OW6 A;  1LQ7 A;  3CV5 A;  1QWN A;  2D4C A;  2OBL A;  2OO2 A;  3BVW A;  3HAH A;  4EZQ A;  3O3M B;  3D2E A;  1WDZ A;  4ATM A;  1I4L A;  3BVT A;  3ACO A;  3BVX A;  4JWC A;  2Q12 A;  3T46 A;  4EZT A;  2FYV A;  1I4D A;  2EX3 B;  2WYI A;  3QNJ A;  4AKV A;  1QWU A;  2PMR A;  3EJP A;  4FZO A;  4EZU A;  4EZP A;  4R5K A;  2EWF A;  2JNK A;  3GI7 A;  3O3O B;  3G9G A;  2YL8 A;  1HWW A;  2F18 A;  1E9V A;  4UDX X;  4EZV A;  4D8J A;  1I49 A;  3ZED A;  3Q0K A;  1HXK A;  3D4Y A;  1TQV A;  2F7R A;  1O7D B;  1GNT A;  2PY6 A;  1YWM A;  1TQW A;  4FM3 A;  4R5J A;  3L3P A;  2F7Q A;  3PLT A;  4R5L A;  4IM0 A;  1X03 A;  1TQT A;  4JLC A;  4IM3 A;  3UIT A;  4EZY A;  4JNF A;  5C5B A;  2RAI A;  4KIK A;  4R5G A;  4IW0 A;  2NCZ A;  4WPE A;  3D51 A;  3DX1 A;  3D4Z A;  1Y2O A;  2GAF D;  3KAW A;  1HTY A;  4AZB A;  2GF4 A;  1R34 A;  1UPX A;  3BUI A;  4F01 A;  1OA0 A;  3EJT A;  3F7W A;  3VKH A;  2WYH A;  4NPH A;  3CZN A;  2X3W A;  3HAI A;  4I1Q A;  3D50 A;  3T47 A;  2YI9 A;  4JNE A;  2QXL A;  3T49 A;  5FLE X;  3OHX M;  2N3K A;  2EFK A;  3BVV A;  4EZR A;  5KBP A;  1E1D A;  3HAJ A;  2D1L A;  3QNI A;  3CKD A;  4IWO A;  1GNL A;  4B9Q A;  3D52 A;  2F7O A;  4AZC B;  3QWE A;  1PS3 A;  2Z0O A;  4JWD A;  3RPM A;  4R5I A;  1DKZ A;  2QFF A;  2F1A A;  1ZWW A;  2RAK A;  2KHO A;  3OWG A;  3O3N B;  4EZO A;  1TQS A;  2O0I 1;  1QX1 A;  4WPC A;  2YIB A;  3EJR A;  3BUP A;  3DPQ A;  4AZ5 A;  2YL6 A;  4PO2 A;  5FIG A;  3CVR A;  3EJQ A;  1W9M A;  4DYL A;  4JWI A;  4EZN A;  1ZYL A;  4G6Q A;  2Z0V A;  4AVM A;  3I01 A;  1JQK A;  2GA9 D;  3SOG A;  3KAV A;  3QE6 A;  3DX4 A;  3C7N A;  1E2U A;  3BUD A;  4BNE A;  1SUF A;  2ND1 A;  3LMF A;  4AZ6 A;  4KIK B;  3DX0 A;  3ABH A;  2YI8 A;  3B51 X;  3BUB A;  3OK8 A;  4IWQ A;  1DKY A;  3A98 A;  4JL9 A;  3CAZ A;  3I39 X;  2X3X A;  1X04 A;  2RT6 A;  3I04 A;  4IWP A;  4UDY X;  4AZ7 A;  4H6I A;  3QA8 A; 
#chains in the Genus database with same CATH homology
 3DX0 A;  1HXK A;  3DDG A;  3CZS A;  3EJT A;  3D4Y A;  1TQV A;  2F7R A;  3CV5 A;  3D52 A;  1O7D B;  1QWN A;  2WYI A;  3BUQ A;  2F7P A;  3BUB A;  2F7O A;  1QWU A;  2WYH A;  3EJP A;  3CZN A;  1TQS A;  3BVW A;  1PS3 A;  1QX1 A;  1TQU A;  3D51 A;  3DX1 A;  3EJR A;  1R33 A;  2ALW A;  3D4Z A;  3D50 A;  2F1B A;  3BUP A;  3DX4 A;  1TQW A;  2F7Q A;  1HTY A;  3BUD A;  3DX2 A;  3EJS A;  2F1A A;  1HWW A;  3EJU A;  3DDF A;  1R34 A;  3EJQ A;  2F18 A;  3BVT A;  3BLB A;  1TQT A;  3BVX A;  2OW7 A;  3LVT A;  3BVU A;  3BVV A;  5KBP A;  1O7D C;  3DX3 A;  3BUI A;  2FYV A;  2OW6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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