2EFKA

Crystal structure of the efc domain of cdc42-interacting protein 4
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
280
structure length
273
Chain Sequence
GQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Endocytosis/exocytosis
molecule keywords Cdc42-interacting protein 4
publication title Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
pubmed doi rcsb
source organism Homo sapiens
total genus 118
structure length 273
sequence length 280
ec nomenclature
pdb deposition date 2007-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00611 FCH Fes/CIP4, and EFC/F-BAR homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2efkA01
4AVMA 2Z0OA 1I49A 1I4TA 2V0OA 4H8SA 4NQIA 2Q13A 3HAJA 3Q0KA 1X04A 3QWEA 3QNIA 3SYVA 2D4CA 3Q84A 1Y2OA 4WPCA 1ZWWA 3DYTA 4AKVA 3PLTA 4ATMA 2YKTA 1I4LA 4FZSA 4DYLA 1URUA 2RAKA 3OK8A 3CAZA 2D1LA 1I4DA 3QE6A 2EFKA 3G9GA 3HAIA 3LLLA 3ACOA 2RAIA 5C5BA 4BNEA 2EFLA 2Q12A 1WDZA 2X3XA 2ELBA 2X3VA 2X3WA 2Z0NA 4I1QA 3SOGA 1X03A 3HAHA 3ABHA 3M3WA 3I2WA 2C08A 4NSWA 2FICA 2RAJA 4DCNC 5C5BB 2Z0VA 4WPEA
chains in the Genus database with same CATH superfamily
1I4TA 4FZOA 4D8JA 2GF4A 3OWGA 3DX4A 5TKYA 4EZNA 3BUPA 1GN9A 2LXYA 2QKWA 3DDFA 3DPQA 4EZRA 3EJUA 1TQVA 4NPHA 1U00A 1TQUA 4FZSA 3D51A 3F7WA 4H6HA 4EZOA 4JWIA 3VKHA 1MJGA 1TQTA 4IM3A 3EJQA 3SYVA 3O3MB 2OBLA 4R5GA 1SU6A 4JWEA 1DKYA 2PMRA 2D1LA 5E84A 2ELBA 3A98A 3QNJA 4KIKA 4EZTA 2Z0VA 3EJTA 2JNKA 3DX1A 4H6IA 4AZCA 4AZ5A 3ABHA 3M3WA 3BUBA 4F00A 1TQSA 3I01A 4IW0A 3T4AG 1PS3A 2Z0OA 2RT6A 5FLEX 3HAJA 2O0I1 4WPCA 2PY6A 4JWDA 3EJSA 4BNEA 2EFLA 2ZXQA 4I1QA 4IWPA 3I2WA 2FICA 5KBPA 1OA0A 1O7DB 2RAJA 3DPOA 3KDRA 4AVMA 4R5LA 2V0OA 2OW7A 2F7PA 3ER9B 3Q0KA 3QNIA 2OW6A 3DPPA 1DKZA 2MI7A 4F01A 2F7OA 4UDXX 1W9MA 2JNSA 4EZZA 4G6QA 2RAIA 1YWMA 4EZWA 2X3XA 1SU7A 3SOGA 2YIAA 2C08A 1ZYLA 5C5BB 4WPEA 2YIVX 2OO2A 2WINM 4IM2A 3CVRA 1UPXA 3EJPA 4M0MA 2WYIA 2YKTA 1LQ7A 4JL9A 3VEAA 3UITA 3BVTA 3G9GA 3LLLA 4IWQA 4AZ6A 2FYVA 4DCNC 2QFFA 1I49A 1HTYA 2YI9A 1HWWA 3B51X 1GNLA 3D52A 3BVXA 3ER8C 4EZUA 2EFKA 1HXKA 3HAIA 3BVUA 3DX3A 3D2FA 3OHXM 3DDGA 3CZSA 3DX2A 2YL5A 1E2UA 4JNEA 4HR1B 1QWUA 4AZHA 3D4YA 4AZIA 4NQIA 2F7RA 3VEBA 3T47A 2YI8A 2D4CA 3L3OM 3PLTA 1OA1A 3OK8A 3I39X 1R33A 2GAFD 4R5JA 4EZVA 2N3KA 2YLLA 3BLBA 1O7DC 1E9VA 2Q13A 1OAOA 2ND1A 4DYLA 3O3NB 3ZEDA 2YIBA 1QWNA 2Q12A 3KAWA 3HAHA 2EX3B 2EWFA 1SU8A 1QX1A 4FZPA 3I04A 1Y2OA 2ALWA 4JNFA 3CV5A 2RAKA 1R34A 2F1BA 3T49A 2OZNB 3KAVA 2YL8A 4EZQA 4E3CA 4UDYX 3QWEA 4AZGA 3B52X 2ND0A 2YL6A 4IM0A 5C5BA 2X3WA 2X3VA 1DKXA 3RV1A 2F1AA 3BUQA 5FIGA 2F7QA 3BUIA 4FM3A 3QA8A 1TQWA 2GA9D 3Q84A 3B53X 4EZYA 3ERCC 1URUA 2F18A 4R5IA 4AZBA 3QE6A 1JQKA 2Z0NA 3EJRA 2OBMA 4E81A 4JLCA 3LVTA 2LM0A 3FD9A 4B9QA 3LMFA 4HYBA 3D50A 3RV0A 3CZNA 2YLAA 4KIKB 3RPMA 2KHOA 4AKVA 4EZSA 4HR1A 4PO2A 1WDZA 4AZ7A 2Z8YA 1E1DA 4AZCB 3GI7A 4NSWA 3L3PA 3BVWA 4HY9A 4H8SA 3T48A 3BVVA 4EZXA 3T46A 1ZWWA 1GNTA 2YL9A 2WYHA 3CAZA 3O3OB 3ACOA 3C7NA 3BUDA 1X03A 4JN4A 4R5KA 1X04A 4ATMA 3DYTA 3CKDA 1I4LA 2NCZA 1R5EA 3D4ZA 4EZPA 1SUFA 4JWCA 4IWOA 1I4DA 2QXLA 3D2EA 3DX0A 2X5CA
chains in the Genus database with same CATH topology
4AVMA 2Z0OA 1I49A 1I4TA 2V0OA 4H8SA 4NQIA 2Q13A 3HAJA 3Q0KA 1X04A 3QWEA 3QNIA 3SYVA 2D4CA 3Q84A 1Y2OA 4WPCA 1ZWWA 3DYTA 4AKVA 3PLTA 4ATMA 2YKTA 1I4LA 4FZSA 4DYLA 1URUA 2RAKA 3OK8A 3CAZA 2D1LA 1I4DA 3QE6A 2EFKA 3G9GA 3HAIA 3LLLA 3ACOA 2RAIA 5C5BA 4BNEA 2EFLA 2Q12A 1WDZA 2X3XA 2ELBA 2X3VA 2X3WA 2Z0NA 4I1QA 3SOGA 1X03A 3HAHA 3ABHA 3M3WA 3I2WA 2C08A 4NSWA 2FICA 2RAJA 4DCNC 5C5BB 2Z0VA 4WPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AVM A;  2Z0O A;  1I49 A;  1I4T A;  2V0O A;  4H8S A;  4NQI A;  2Q13 A;  3HAJ A;  3Q0K A;  1X04 A;  3QWE A;  3QNI A;  3SYV A;  2D4C A;  3Q84 A;  1Y2O A;  4WPC A;  1ZWW A;  3DYT A;  4AKV A;  3PLT A;  4ATM A;  2YKT A;  1I4L A;  4FZS A;  4DYL A;  1URU A;  2RAK A;  3OK8 A;  3CAZ A;  2D1L A;  1I4D A;  3QE6 A;  2EFK A;  3G9G A;  3HAI A;  3LLL A;  3ACO A;  2RAI A;  5C5B A;  4BNE A;  2EFL A;  2Q12 A;  1WDZ A;  2X3X A;  2ELB A;  2X3V A;  2X3W A;  2Z0N A;  4I1Q A;  3SOG A;  1X03 A;  3HAH A;  3ABH A;  3M3W A;  3I2W A;  2C08 A;  4NSW A;  2FIC A;  2RAJ A;  4DCN C;  5C5B B;  2Z0V A;  4WPE A; 
#chains in the Genus database with same CATH topology
 1I4T A;  4FZO A;  4D8J A;  2GF4 A;  3OWG A;  3DX4 A;  5TKY A;  4EZN A;  3BUP A;  1GN9 A;  2LXY A;  2QKW A;  3DDF A;  3DPQ A;  4EZR A;  3EJU A;  1TQV A;  4NPH A;  1U00 A;  1TQU A;  4FZS A;  3D51 A;  3F7W A;  4H6H A;  4EZO A;  4JWI A;  3VKH A;  1MJG A;  1TQT A;  4IM3 A;  3EJQ A;  3SYV A;  3O3M B;  2OBL A;  4R5G A;  1SU6 A;  4JWE A;  1DKY A;  2PMR A;  2D1L A;  5E84 A;  2ELB A;  3A98 A;  3QNJ A;  4KIK A;  4EZT A;  2Z0V A;  3EJT A;  2JNK A;  3DX1 A;  4H6I A;  4AZC A;  4AZ5 A;  3ABH A;  3M3W A;  3BUB A;  4F00 A;  1TQS A;  3I01 A;  4IW0 A;  3T4A G;  1PS3 A;  2Z0O A;  2RT6 A;  5FLE X;  3HAJ A;  2O0I 1;  4WPC A;  2PY6 A;  4JWD A;  3EJS A;  4BNE A;  2EFL A;  2ZXQ A;  4I1Q A;  4IWP A;  3I2W A;  2FIC A;  5KBP A;  1OA0 A;  1O7D B;  2RAJ A;  3DPO A;  3KDR A;  4AVM A;  4R5L A;  2V0O A;  2OW7 A;  2F7P A;  3ER9 B;  3Q0K A;  3QNI A;  2OW6 A;  3DPP A;  1DKZ A;  2MI7 A;  4F01 A;  2F7O A;  4UDX X;  1W9M A;  2JNS A;  4EZZ A;  4G6Q A;  2RAI A;  1YWM A;  4EZW A;  2X3X A;  1SU7 A;  3SOG A;  2YIA A;  2C08 A;  1ZYL A;  5C5B B;  4WPE A;  2YIV X;  2OO2 A;  2WIN M;  4IM2 A;  3CVR A;  1UPX A;  3EJP A;  4M0M A;  2WYI A;  2YKT A;  1LQ7 A;  4JL9 A;  3VEA A;  3UIT A;  3BVT A;  3G9G A;  3LLL A;  4IWQ A;  4AZ6 A;  2FYV A;  4DCN C;  2QFF A;  1I49 A;  1HTY A;  2YI9 A;  1HWW A;  3B51 X;  1GNL A;  3D52 A;  3BVX A;  3ER8 C;  4EZU A;  2EFK A;  1HXK A;  3HAI A;  3BVU A;  3DX3 A;  3D2F A;  3OHX M;  3DDG A;  3CZS A;  3DX2 A;  2YL5 A;  1E2U A;  4JNE A;  4HR1 B;  1QWU A;  4AZH A;  3D4Y A;  4AZI A;  4NQI A;  2F7R A;  3VEB A;  3T47 A;  2YI8 A;  2D4C A;  3L3O M;  3PLT A;  1OA1 A;  3OK8 A;  3I39 X;  1R33 A;  2GAF D;  4R5J A;  4EZV A;  2N3K A;  2YLL A;  3BLB A;  1O7D C;  1E9V A;  2Q13 A;  1OAO A;  2ND1 A;  4DYL A;  3O3N B;  3ZED A;  2YIB A;  1QWN A;  2Q12 A;  3KAW A;  3HAH A;  2EX3 B;  2EWF A;  1SU8 A;  1QX1 A;  4FZP A;  3I04 A;  1Y2O A;  2ALW A;  4JNF A;  3CV5 A;  2RAK A;  1R34 A;  2F1B A;  3T49 A;  2OZN B;  3KAV A;  2YL8 A;  4EZQ A;  4E3C A;  4UDY X;  3QWE A;  4AZG A;  3B52 X;  2ND0 A;  2YL6 A;  4IM0 A;  5C5B A;  2X3W A;  2X3V A;  1DKX A;  3RV1 A;  2F1A A;  3BUQ A;  5FIG A;  2F7Q A;  3BUI A;  4FM3 A;  3QA8 A;  1TQW A;  2GA9 D;  3Q84 A;  3B53 X;  4EZY A;  3ERC C;  1URU A;  2F18 A;  4R5I A;  4AZB A;  3QE6 A;  1JQK A;  2Z0N A;  3EJR A;  2OBM A;  4E81 A;  4JLC A;  3LVT A;  2LM0 A;  3FD9 A;  4B9Q A;  3LMF A;  4HYB A;  3D50 A;  3RV0 A;  3CZN A;  2YLA A;  4KIK B;  3RPM A;  2KHO A;  4AKV A;  4EZS A;  4HR1 A;  4PO2 A;  1WDZ A;  4AZ7 A;  2Z8Y A;  1E1D A;  4AZC B;  3GI7 A;  4NSW A;  3L3P A;  3BVW A;  4HY9 A;  4H8S A;  3T48 A;  3BVV A;  4EZX A;  3T46 A;  1ZWW A;  1GNT A;  2YL9 A;  2WYH A;  3CAZ A;  3O3O B;  3ACO A;  3C7N A;  3BUD A;  1X03 A;  4JN4 A;  4R5K A;  1X04 A;  4ATM A;  3DYT A;  3CKD A;  1I4L A;  2NCZ A;  1R5E A;  3D4Z A;  4EZP A;  1SUF A;  4JWC A;  4IWO A;  1I4D A;  2QXL A;  3D2E A;  3DX0 A;  2X5C A; 
#chains in the Genus database with same CATH homology
 4AVM A;  2Z0O A;  1I49 A;  1I4T A;  2V0O A;  4H8S A;  4NQI A;  2Q13 A;  3HAJ A;  3Q0K A;  1X04 A;  3QWE A;  3QNI A;  3SYV A;  2D4C A;  3Q84 A;  1Y2O A;  4WPC A;  1ZWW A;  3DYT A;  4AKV A;  3PLT A;  4ATM A;  2YKT A;  1I4L A;  4FZS A;  4DYL A;  1URU A;  2RAK A;  3OK8 A;  3CAZ A;  2D1L A;  1I4D A;  3QE6 A;  2EFK A;  3G9G A;  3HAI A;  3LLL A;  3ACO A;  2RAI A;  5C5B A;  4BNE A;  2EFL A;  2Q12 A;  1WDZ A;  2X3X A;  2ELB A;  2X3V A;  2X3W A;  2Z0N A;  4I1Q A;  3SOG A;  1X03 A;  3HAH A;  3ABH A;  3M3W A;  3I2W A;  2C08 A;  4NSW A;  2FIC A;  2RAJ A;  4DCN C;  5C5B B;  2Z0V A;  4WPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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