2Q12A

Crystal structure of bar domain of appl1
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
247
structure length
242
Chain Sequence
LEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein transport
molecule keywords DCC-interacting protein 13 alpha
publication title Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 242
sequence length 247
ec nomenclature
pdb deposition date 2007-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16746 BAR_3 BAR domain of APPL family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2q12A00
1I49A 2RAKA 3CAZA 3M3WA 5C5BA 3DYTA 3PLTA 3QWEA 4WPCA 2V0OA 3QE6A 1WDZA 2C08A 1ZWWA 4BNEA 4I1QA 3QNIA 2D1LA 2RAJA 4AKVA 1Y2OA 3SOGA 3Q84A 2X3XA 4NQIA 1I4LA 2FICA 3ACOA 2D4CA 3HAHA 3I2WA 3OK8A 4DYLA 3G9GA 3Q0KA 2Z0VA 3SYVA 1X03A 3ABHA 4H8SA 3HAJA 4DCNC 3LLLA 4FZSA 2X3VA 4NSWA 2Z0NA 2YKTA 4ATMA 2Q13A 2EFKA 2RAIA 2X3WA 3HAIA 5C5BB 4AVMA 4WPEA 1X04A 2ELBA 2Z0OA 1URUA 1I4TA 1I4DA 2EFLA 2Q12A
chains in the Genus database with same CATH superfamily
3CZNA 4D8JA 1PS3A 2QKWA 3D4ZA 3B51X 3T4AG 3KAWA 3CVRA 4H6IA 2JNSA 3ER9B 3ABHA 1SU7A 1E9VA 2KHOA 3DX2A 3PLTA 1DKYA 2F7PA 1DKXA 1SUFA 3SOGA 3Q84A 4G6QA 2X5CA 2YLLA 3Q0KA 1YWMA 4IWQA 2OW6A 3D52A 3ER8C 3DX3A 2Q13A 2RAIA 1R33A 2F7RA 3VEBA 3QWEA 4EZPA 2V0OA 3I39X 2RAJA 1R34A 1TQUA 1I4LA 4AZIA 4AZ5A 2Z8YA 3L3OM 2YL8A 3BUIA 4IM0A 4EZQA 3D4YA 3DPOA 4R5GA 2WYIA 1I49A 4AZ6A 3EJUA 4EZXA 3I04A 3O3MB 4R5LA 2F1AA 2OW7A 4EZZA 4HY9A 3ERCC 3DX1A 4B9QA 3OK8A 2YIAA 1O7DC 3CKDA 1ZYLA 2EX3B 3DDGA 1SU8A 2YKTA 3EJTA 4HR1B 1HXKA 1TQWA 4AKVA 3KDRA 3BUBA 2YLAA 4AZCB 1QX1A 3ZEDA 1SU6A 5KBPA 3C7NA 1QWUA 1I4DA 2RAKA 3OWGA 4UDXX 2OO2A 3UITA 4JN4A 4FZPA 3T49A 4ATMA 2EFKA 5C5BB 4IM3A 3L3PA 1O7DB 4IWOA 3DYTA 3GI7A 2F7OA 2ND0A 2YI9A 2X3VA 3HAIA 3BUQA 1GNTA 4KIKA 3T47A 2ALWA 3M3WA 3D50A 1HWWA 4HR1A 3DX4A 4EZNA 3I2WA 3G9GA 2YI8A 4PO2A 4R5KA 3LLLA 3BUPA 2NCZA 3EJRA 4R5IA 4AZCA 4H8SA 2YIVX 4IWPA 1GN9A 2FYVA 2RT6A 2YL6A 4WPCA 3VKHA 4EZVA 3QNIA 1R5EA 1OA0A 4NQIA 4NPHA 2Z0VA 2O0I1 4R5JA 2ND1A 3B52X 2EWFA 2OBLA 3O3OB 4EZSA 3BUDA 4FZOA 2MI7A 1E2UA 3QE6A 3F7WA 4BNEA 4I1QA 4JWIA 2X3XA 4E3CA 4JNFA 1W9MA 3KAVA 3D51A 3A98A 4AZ7A 3T48A 2YL5A 4H6HA 2WINM 2LXYA 3RPMA 1OA1A 3CAZA 3O3NB 3FD9A 4JWEA 3RV0A 3CV5A 3HAJA 4EZWA 4HYBA 4M0MA 4AVMA 2GF4A 3BVVA 4JL9A 1E1DA 2OBMA 2WYHA 2LM0A 4EZUA 1DKZA 3EJSA 1OAOA 4AZHA 2FICA 3SYVA 2Z0NA 4EZRA 1URUA 3LVTA 2PY6A 1TQSA 4EZTA 4FM3A 5FIGA 5TKYA 1JQKA 5E84A 4E81A 3DX0A 3ACOA 3HAHA 2QFFA 4FZSA 3D2EA 3QNJA 2JNKA 3BVUA 1U00A 2OZNB 4JWDA 3VEAA 4UDYX 3DPQA 3RV1A 2GAFD 3OHXM 4IM2A 1QWNA 3I01A 4F01A 4NSWA 4WPEA 3BVWA 2ELBA 5FLEX 1I4TA 2EFLA 3DDFA 5C5BA 3QA8A 3LMFA 1UPXA 2C08A 1ZWWA 3T46A 1TQVA 2D1LA 2PMRA 2YL9A 1Y2OA 2F1BA 2D4CA 4KIKB 4F00A 1X03A 2GA9D 3EJQA 3BVTA 4JWCA 2Z0OA 1HTYA 4AZGA 1GNLA 2F18A 4EZOA 3BLBA 2F7QA 1LQ7A 1TQTA 1WDZA 4JLCA 2N3KA 3BVXA 3DPPA 4JNEA 4IW0A 2QXLA 4AZBA 2YIBA 2ZXQA 3B53X 1MJGA 4DYLA 3CZSA 4DCNC 3EJPA 3D2FA 2X3WA 4EZYA 1X04A 2Q12A
chains in the Genus database with same CATH topology
1I49A 2RAKA 3CAZA 3M3WA 5C5BA 3DYTA 3PLTA 3QWEA 4WPCA 2V0OA 3QE6A 1WDZA 2C08A 1ZWWA 4BNEA 4I1QA 3QNIA 2D1LA 2RAJA 4AKVA 1Y2OA 3SOGA 3Q84A 2X3XA 4NQIA 1I4LA 2FICA 3ACOA 2D4CA 3HAHA 3I2WA 3OK8A 4DYLA 3G9GA 3Q0KA 2Z0VA 3SYVA 1X03A 3ABHA 4H8SA 3HAJA 4DCNC 3LLLA 4FZSA 2X3VA 4NSWA 2Z0NA 2YKTA 4ATMA 2Q13A 2EFKA 2RAIA 2X3WA 3HAIA 5C5BB 4AVMA 4WPEA 1X04A 2ELBA 2Z0OA 1URUA 1I4TA 1I4DA 2EFLA 2Q12A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I49 A;  2RAK A;  3CAZ A;  3M3W A;  5C5B A;  3DYT A;  3PLT A;  3QWE A;  4WPC A;  2V0O A;  3QE6 A;  1WDZ A;  2C08 A;  1ZWW A;  4BNE A;  4I1Q A;  3QNI A;  2D1L A;  2RAJ A;  4AKV A;  1Y2O A;  3SOG A;  3Q84 A;  2X3X A;  4NQI A;  1I4L A;  2FIC A;  3ACO A;  2D4C A;  3HAH A;  3I2W A;  3OK8 A;  4DYL A;  3G9G A;  3Q0K A;  2Z0V A;  3SYV A;  1X03 A;  3ABH A;  4H8S A;  3HAJ A;  4DCN C;  3LLL A;  4FZS A;  2X3V A;  4NSW A;  2Z0N A;  2YKT A;  4ATM A;  2Q13 A;  2EFK A;  2RAI A;  2X3W A;  3HAI A;  5C5B B;  4AVM A;  4WPE A;  1X04 A;  2ELB A;  2Z0O A;  1URU A;  1I4T A;  1I4D A;  2EFL A;  2Q12 A; 
#chains in the Genus database with same CATH topology
 3CZN A;  4D8J A;  1PS3 A;  2QKW A;  3D4Z A;  3B51 X;  3T4A G;  3KAW A;  3CVR A;  4H6I A;  2JNS A;  3ER9 B;  3ABH A;  1SU7 A;  1E9V A;  2KHO A;  3DX2 A;  3PLT A;  1DKY A;  2F7P A;  1DKX A;  1SUF A;  3SOG A;  3Q84 A;  4G6Q A;  2X5C A;  2YLL A;  3Q0K A;  1YWM A;  4IWQ A;  2OW6 A;  3D52 A;  3ER8 C;  3DX3 A;  2Q13 A;  2RAI A;  1R33 A;  2F7R A;  3VEB A;  3QWE A;  4EZP A;  2V0O A;  3I39 X;  2RAJ A;  1R34 A;  1TQU A;  1I4L A;  4AZI A;  4AZ5 A;  2Z8Y A;  3L3O M;  2YL8 A;  3BUI A;  4IM0 A;  4EZQ A;  3D4Y A;  3DPO A;  4R5G A;  2WYI A;  1I49 A;  4AZ6 A;  3EJU A;  4EZX A;  3I04 A;  3O3M B;  4R5L A;  2F1A A;  2OW7 A;  4EZZ A;  4HY9 A;  3ERC C;  3DX1 A;  4B9Q A;  3OK8 A;  2YIA A;  1O7D C;  3CKD A;  1ZYL A;  2EX3 B;  3DDG A;  1SU8 A;  2YKT A;  3EJT A;  4HR1 B;  1HXK A;  1TQW A;  4AKV A;  3KDR A;  3BUB A;  2YLA A;  4AZC B;  1QX1 A;  3ZED A;  1SU6 A;  5KBP A;  3C7N A;  1QWU A;  1I4D A;  2RAK A;  3OWG A;  4UDX X;  2OO2 A;  3UIT A;  4JN4 A;  4FZP A;  3T49 A;  4ATM A;  2EFK A;  5C5B B;  4IM3 A;  3L3P A;  1O7D B;  4IWO A;  3DYT A;  3GI7 A;  2F7O A;  2ND0 A;  2YI9 A;  2X3V A;  3HAI A;  3BUQ A;  1GNT A;  4KIK A;  3T47 A;  2ALW A;  3M3W A;  3D50 A;  1HWW A;  4HR1 A;  3DX4 A;  4EZN A;  3I2W A;  3G9G A;  2YI8 A;  4PO2 A;  4R5K A;  3LLL A;  3BUP A;  2NCZ A;  3EJR A;  4R5I A;  4AZC A;  4H8S A;  2YIV X;  4IWP A;  1GN9 A;  2FYV A;  2RT6 A;  2YL6 A;  4WPC A;  3VKH A;  4EZV A;  3QNI A;  1R5E A;  1OA0 A;  4NQI A;  4NPH A;  2Z0V A;  2O0I 1;  4R5J A;  2ND1 A;  3B52 X;  2EWF A;  2OBL A;  3O3O B;  4EZS A;  3BUD A;  4FZO A;  2MI7 A;  1E2U A;  3QE6 A;  3F7W A;  4BNE A;  4I1Q A;  4JWI A;  2X3X A;  4E3C A;  4JNF A;  1W9M A;  3KAV A;  3D51 A;  3A98 A;  4AZ7 A;  3T48 A;  2YL5 A;  4H6H A;  2WIN M;  2LXY A;  3RPM A;  1OA1 A;  3CAZ A;  3O3N B;  3FD9 A;  4JWE A;  3RV0 A;  3CV5 A;  3HAJ A;  4EZW A;  4HYB A;  4M0M A;  4AVM A;  2GF4 A;  3BVV A;  4JL9 A;  1E1D A;  2OBM A;  2WYH A;  2LM0 A;  4EZU A;  1DKZ A;  3EJS A;  1OAO A;  4AZH A;  2FIC A;  3SYV A;  2Z0N A;  4EZR A;  1URU A;  3LVT A;  2PY6 A;  1TQS A;  4EZT A;  4FM3 A;  5FIG A;  5TKY A;  1JQK A;  5E84 A;  4E81 A;  3DX0 A;  3ACO A;  3HAH A;  2QFF A;  4FZS A;  3D2E A;  3QNJ A;  2JNK A;  3BVU A;  1U00 A;  2OZN B;  4JWD A;  3VEA A;  4UDY X;  3DPQ A;  3RV1 A;  2GAF D;  3OHX M;  4IM2 A;  1QWN A;  3I01 A;  4F01 A;  4NSW A;  4WPE A;  3BVW A;  2ELB A;  5FLE X;  1I4T A;  2EFL A;  3DDF A;  5C5B A;  3QA8 A;  3LMF A;  1UPX A;  2C08 A;  1ZWW A;  3T46 A;  1TQV A;  2D1L A;  2PMR A;  2YL9 A;  1Y2O A;  2F1B A;  2D4C A;  4KIK B;  4F00 A;  1X03 A;  2GA9 D;  3EJQ A;  3BVT A;  4JWC A;  2Z0O A;  1HTY A;  4AZG A;  1GNL A;  2F18 A;  4EZO A;  3BLB A;  2F7Q A;  1LQ7 A;  1TQT A;  1WDZ A;  4JLC A;  2N3K A;  3BVX A;  3DPP A;  4JNE A;  4IW0 A;  2QXL A;  4AZB A;  2YIB A;  2ZXQ A;  3B53 X;  1MJG A;  4DYL A;  3CZS A;  4DCN C;  3EJP A;  3D2F A;  2X3W A;  4EZY A;  1X04 A;  2Q12 A; 
#chains in the Genus database with same CATH homology
 1I49 A;  2RAK A;  3CAZ A;  3M3W A;  5C5B A;  3DYT A;  3PLT A;  3QWE A;  4WPC A;  2V0O A;  3QE6 A;  1WDZ A;  2C08 A;  1ZWW A;  4BNE A;  4I1Q A;  3QNI A;  2D1L A;  2RAJ A;  4AKV A;  1Y2O A;  3SOG A;  3Q84 A;  2X3X A;  4NQI A;  1I4L A;  2FIC A;  3ACO A;  2D4C A;  3HAH A;  3I2W A;  3OK8 A;  4DYL A;  3G9G A;  3Q0K A;  2Z0V A;  3SYV A;  1X03 A;  3ABH A;  4H8S A;  3HAJ A;  4DCN C;  3LLL A;  4FZS A;  2X3V A;  4NSW A;  2Z0N A;  2YKT A;  4ATM A;  2Q13 A;  2EFK A;  2RAI A;  2X3W A;  3HAI A;  5C5B B;  4AVM A;  4WPE A;  1X04 A;  2ELB A;  2Z0O A;  1URU A;  1I4T A;  1I4D A;  2EFL A;  2Q12 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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