1I4TA

Crystal structure analysis of rac1-gmppnp in complex with arfaptin
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
195
structure length
180
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 83
structure length 180
sequence length 195
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4tA00
4ATMA 1ZWWA 4I1QA 1URUA 3HAIA 3M3WA 4AVMA 3DYTA 3G9GA 3LLLA 1I4LA 2D4CA 2Q13A 3HAHA 4NQIA 4DCNC 3QE6A 2EFLA 3I2WA 2RAIA 4NSWA 3QWEA 1X03A 1I4TA 2RAKA 2V0OA 3OK8A 5C5BB 3ABHA 3PLTA 1I4DA 3HAJA 2ELBA 2Z0NA 3SYVA 2YKTA 2FICA 2X3XA 3SOGA 4AKVA 4WPEA 3Q84A 2X3VA 2Z0VA 3QNIA 2X3WA 4BNEA 1X04A 4FZSA 4WPCA 4DYLA 3ACOA 2Q12A 2C08A 3CAZA 3Q0KA 5C5BA 1Y2OA 4H8SA 2RAJA 1I49A 2D1LA 1WDZA 2EFKA 2Z0OA
chains in the Genus database with same CATH superfamily
4I1QA 3DYTA 3O3MB 3KDRA 2N3KA 2GA9D 4HR1A 1O7DC 2OBLA 3VEAA 4IWPA 3DPOA 2YLLA 1I4DA 1UPXA 1SUFA 3OWGA 1U00A 4BNEA 3CZSA 2ND0A 4HR1B 3CAZA 5TKYA 3VKHA 4R5JA 1URUA 2F7PA 2Q13A 3HAHA 3KAVA 4JN4A 2RAKA 4JWDA 3ER9B 2F1BA 4UDYX 1OA0A 2X3VA 3DX2A 2F7QA 4FZOA 2YI8A 3B53X 4AZIA 4JWEA 2EWFA 2PY6A 3HAIA 3M3WA 3T48A 3I2WA 1GNLA 1QWUA 3LVTA 1W9MA 3B52X 4AZBA 4JNEA 3GI7A 4R5IA 4IM3A 2Z0OA 3CV5A 4EZUA 2MI7A 3RPMA 4EZNA 2YL6A 4R5LA 2FYVA 2YKTA 3DPPA 2Z0VA 4JLCA 4EZYA 5KBPA 2OO2A 2Q12A 2WYIA 4E81A 3QA8A 4HY9A 4JWCA 3RV0A 1I4LA 3BUDA 3BVXA 3QE6A 3SYVA 2JNSA 4AZ5A 2RT6A 2YIVX 4IW0A 4B9QA 4IM2A 3BVVA 3BVTA 4AZ7A 4FM3A 1Y2OA 2X5CA 2YIAA 1MJGA 3BUIA 3VEBA 4HYBA 2YIBA 4E3CA 4F01A 1I4TA 2F7RA 3D50A 3O3NB 5C5BB 4IWQA 1QWNA 4M0MA 1DKYA 3Q84A 4EZTA 4WPCA 2F1AA 3LLLA 2EFLA 2QXLA 2WYHA 1DKZA 2ALWA 3D4ZA 3PLTA 2QKWA 5FLEX 1TQVA 3FD9A 3T4AG 3Q0KA 1E9VA 4EZOA 3ER8C 3DX1A 1ZWWA 4EZPA 2GF4A 3G9GA 2PMRA 3I01A 1LQ7A 1SU8A 3HAJA 3DDFA 5E84A 1OAOA 3D2EA 3RV1A 1X04A 3ACOA 2C08A 4EZZA 2YL8A 3I39X 3CKDA 3BLBA 2ZXQA 3QWEA 3BVWA 3OK8A 1QX1A 4NPHA 1TQSA 4AKVA 2Z8YA 4F00A 4AZCA 2OW7A 4D8JA 3EJSA 1YWMA 3O3OB 2LM0A 3D4YA 3L3PA 4EZVA 2QFFA 4AZGA 3DX4A 4UDXX 4AZCB 3UITA 2GAFD 4R5GA 4JL9A 2JNKA 4G6QA 3EJTA 4JNFA 2Z0NA 4EZQA 2FICA 2YI9A 3A98A 1HWWA 3EJRA 3QNIA 4EZSA 4DYLA 5FIGA 3D2FA 4KIKA 4AZHA 4AVMA 1HTYA 1OA1A 4NQIA 3T46A 3ERCC 2OBMA 2ND1A 3SOGA 3QNJA 4AZ6A 3B51X 1DKXA 2YL9A 3EJPA 1E1DA 3EJQA 1TQWA 4DCNC 4H6IA 1HXKA 3EJUA 2EX3B 1E2UA 3DX3A 2F18A 2LXYA 3DPQA 3CZNA 2RAJA 1TQUA 4IWOA 4EZRA 3T49A 3T47A 2OZNB 1R34A 1SU6A 4EZWA 2OW6A 4FZSA 4H8SA 4JWIA 2D4CA 3CVRA 4R5KA 3KAWA 1X03A 2V0OA 3ABHA 3ZEDA 3OHXM 2X3WA 2O0I1 3I04A 2WINM 1ZYLA 2NCZA 1WDZA 3BUBA 1R5EA 2YL5A 2YLAA 3F7WA 2RAIA 1R33A 3L3OM 4H6HA 3DX0A 1TQTA 3D52A 1JQKA 2X3XA 3BVUA 4WPEA 4EZXA 1GN9A 3D51A 4IM0A 2D1LA 2EFKA 3C7NA 4ATMA 1PS3A 3BUQA 4NSWA 4FZPA 4KIKB 4PO2A 3DDGA 2ELBA 2F7OA 3BUPA 1SU7A 1GNTA 3LMFA 5C5BA 1O7DB 1I49A 2KHOA
chains in the Genus database with same CATH topology
4ATMA 1ZWWA 4I1QA 1URUA 3HAIA 3M3WA 4AVMA 3DYTA 3G9GA 3LLLA 1I4LA 2D4CA 2Q13A 3HAHA 4NQIA 4DCNC 3QE6A 2EFLA 3I2WA 2RAIA 4NSWA 3QWEA 1X03A 1I4TA 2RAKA 2V0OA 3OK8A 5C5BB 3ABHA 3PLTA 1I4DA 3HAJA 2ELBA 2Z0NA 3SYVA 2YKTA 2FICA 2X3XA 3SOGA 4AKVA 4WPEA 3Q84A 2X3VA 2Z0VA 3QNIA 2X3WA 4BNEA 1X04A 4FZSA 4WPCA 4DYLA 3ACOA 2Q12A 2C08A 3CAZA 3Q0KA 5C5BA 1Y2OA 4H8SA 2RAJA 1I49A 2D1LA 1WDZA 2EFKA 2Z0OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ATM A;  1ZWW A;  4I1Q A;  1URU A;  3HAI A;  3M3W A;  4AVM A;  3DYT A;  3G9G A;  3LLL A;  1I4L A;  2D4C A;  2Q13 A;  3HAH A;  4NQI A;  4DCN C;  3QE6 A;  2EFL A;  3I2W A;  2RAI A;  4NSW A;  3QWE A;  1X03 A;  1I4T A;  2RAK A;  2V0O A;  3OK8 A;  5C5B B;  3ABH A;  3PLT A;  1I4D A;  3HAJ A;  2ELB A;  2Z0N A;  3SYV A;  2YKT A;  2FIC A;  2X3X A;  3SOG A;  4AKV A;  4WPE A;  3Q84 A;  2X3V A;  2Z0V A;  3QNI A;  2X3W A;  4BNE A;  1X04 A;  4FZS A;  4WPC A;  4DYL A;  3ACO A;  2Q12 A;  2C08 A;  3CAZ A;  3Q0K A;  5C5B A;  1Y2O A;  4H8S A;  2RAJ A;  1I49 A;  2D1L A;  1WDZ A;  2EFK A;  2Z0O A; 
#chains in the Genus database with same CATH topology
 4I1Q A;  3DYT A;  3O3M B;  3KDR A;  2N3K A;  2GA9 D;  4HR1 A;  1O7D C;  2OBL A;  3VEA A;  4IWP A;  3DPO A;  2YLL A;  1I4D A;  1UPX A;  1SUF A;  3OWG A;  1U00 A;  4BNE A;  3CZS A;  2ND0 A;  4HR1 B;  3CAZ A;  5TKY A;  3VKH A;  4R5J A;  1URU A;  2F7P A;  2Q13 A;  3HAH A;  3KAV A;  4JN4 A;  2RAK A;  4JWD A;  3ER9 B;  2F1B A;  4UDY X;  1OA0 A;  2X3V A;  3DX2 A;  2F7Q A;  4FZO A;  2YI8 A;  3B53 X;  4AZI A;  4JWE A;  2EWF A;  2PY6 A;  3HAI A;  3M3W A;  3T48 A;  3I2W A;  1GNL A;  1QWU A;  3LVT A;  1W9M A;  3B52 X;  4AZB A;  4JNE A;  3GI7 A;  4R5I A;  4IM3 A;  2Z0O A;  3CV5 A;  4EZU A;  2MI7 A;  3RPM A;  4EZN A;  2YL6 A;  4R5L A;  2FYV A;  2YKT A;  3DPP A;  2Z0V A;  4JLC A;  4EZY A;  5KBP A;  2OO2 A;  2Q12 A;  2WYI A;  4E81 A;  3QA8 A;  4HY9 A;  4JWC A;  3RV0 A;  1I4L A;  3BUD A;  3BVX A;  3QE6 A;  3SYV A;  2JNS A;  4AZ5 A;  2RT6 A;  2YIV X;  4IW0 A;  4B9Q A;  4IM2 A;  3BVV A;  3BVT A;  4AZ7 A;  4FM3 A;  1Y2O A;  2X5C A;  2YIA A;  1MJG A;  3BUI A;  3VEB A;  4HYB A;  2YIB A;  4E3C A;  4F01 A;  1I4T A;  2F7R A;  3D50 A;  3O3N B;  5C5B B;  4IWQ A;  1QWN A;  4M0M A;  1DKY A;  3Q84 A;  4EZT A;  4WPC A;  2F1A A;  3LLL A;  2EFL A;  2QXL A;  2WYH A;  1DKZ A;  2ALW A;  3D4Z A;  3PLT A;  2QKW A;  5FLE X;  1TQV A;  3FD9 A;  3T4A G;  3Q0K A;  1E9V A;  4EZO A;  3ER8 C;  3DX1 A;  1ZWW A;  4EZP A;  2GF4 A;  3G9G A;  2PMR A;  3I01 A;  1LQ7 A;  1SU8 A;  3HAJ A;  3DDF A;  5E84 A;  1OAO A;  3D2E A;  3RV1 A;  1X04 A;  3ACO A;  2C08 A;  4EZZ A;  2YL8 A;  3I39 X;  3CKD A;  3BLB A;  2ZXQ A;  3QWE A;  3BVW A;  3OK8 A;  1QX1 A;  4NPH A;  1TQS A;  4AKV A;  2Z8Y A;  4F00 A;  4AZC A;  2OW7 A;  4D8J A;  3EJS A;  1YWM A;  3O3O B;  2LM0 A;  3D4Y A;  3L3P A;  4EZV A;  2QFF A;  4AZG A;  3DX4 A;  4UDX X;  4AZC B;  3UIT A;  2GAF D;  4R5G A;  4JL9 A;  2JNK A;  4G6Q A;  3EJT A;  4JNF A;  2Z0N A;  4EZQ A;  2FIC A;  2YI9 A;  3A98 A;  1HWW A;  3EJR A;  3QNI A;  4EZS A;  4DYL A;  5FIG A;  3D2F A;  4KIK A;  4AZH A;  4AVM A;  1HTY A;  1OA1 A;  4NQI A;  3T46 A;  3ERC C;  2OBM A;  2ND1 A;  3SOG A;  3QNJ A;  4AZ6 A;  3B51 X;  1DKX A;  2YL9 A;  3EJP A;  1E1D A;  3EJQ A;  1TQW A;  4DCN C;  4H6I A;  1HXK A;  3EJU A;  2EX3 B;  1E2U A;  3DX3 A;  2F18 A;  2LXY A;  3DPQ A;  3CZN A;  2RAJ A;  1TQU A;  4IWO A;  4EZR A;  3T49 A;  3T47 A;  2OZN B;  1R34 A;  1SU6 A;  4EZW A;  2OW6 A;  4FZS A;  4H8S A;  4JWI A;  2D4C A;  3CVR A;  4R5K A;  3KAW A;  1X03 A;  2V0O A;  3ABH A;  3ZED A;  3OHX M;  2X3W A;  2O0I 1;  3I04 A;  2WIN M;  1ZYL A;  2NCZ A;  1WDZ A;  3BUB A;  1R5E A;  2YL5 A;  2YLA A;  3F7W A;  2RAI A;  1R33 A;  3L3O M;  4H6H A;  3DX0 A;  1TQT A;  3D52 A;  1JQK A;  2X3X A;  3BVU A;  4WPE A;  4EZX A;  1GN9 A;  3D51 A;  4IM0 A;  2D1L A;  2EFK A;  3C7N A;  4ATM A;  1PS3 A;  3BUQ A;  4NSW A;  4FZP A;  4KIK B;  4PO2 A;  3DDG A;  2ELB A;  2F7O A;  3BUP A;  1SU7 A;  1GNT A;  3LMF A;  5C5B A;  1O7D B;  1I49 A;  2KHO A; 
#chains in the Genus database with same CATH homology
 4ATM A;  1ZWW A;  4I1Q A;  1URU A;  3HAI A;  3M3W A;  4AVM A;  3DYT A;  3G9G A;  3LLL A;  1I4L A;  2D4C A;  2Q13 A;  3HAH A;  4NQI A;  4DCN C;  3QE6 A;  2EFL A;  3I2W A;  2RAI A;  4NSW A;  3QWE A;  1X03 A;  1I4T A;  2RAK A;  2V0O A;  3OK8 A;  5C5B B;  3ABH A;  3PLT A;  1I4D A;  3HAJ A;  2ELB A;  2Z0N A;  3SYV A;  2YKT A;  2FIC A;  2X3X A;  3SOG A;  4AKV A;  4WPE A;  3Q84 A;  2X3V A;  2Z0V A;  3QNI A;  2X3W A;  4BNE A;  1X04 A;  4FZS A;  4WPC A;  4DYL A;  3ACO A;  2Q12 A;  2C08 A;  3CAZ A;  3Q0K A;  5C5B A;  1Y2O A;  4H8S A;  2RAJ A;  1I49 A;  2D1L A;  1WDZ A;  2EFK A;  2Z0O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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