1I4TA

Crystal structure analysis of rac1-gmppnp in complex with arfaptin
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
195
structure length
180
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 83
structure length 180
sequence length 195
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4tA00
3HAHA 4DCNC 2Z0NA 4H8SA 3LLLA 3QNIA 4BNEA 3DYTA 3PLTA 2X3XA 1X04A 3G9GA 4I1QA 2V0OA 1WDZA 2Z0OA 3I2WA 3HAIA 3QWEA 4NQIA 4DYLA 2ELBA 4AKVA 1I4DA 2FICA 2Q13A 2Z0VA 1X03A 3HAJA 2RAJA 2EFLA 2RAKA 2X3VA 4WPCA 3SOGA 3ABHA 4NSWA 2Q12A 3OK8A 2RAIA 4ATMA 1I4LA 1URUA 2X3WA 3CAZA 2D4CA 3Q84A 4FZSA 2EFKA 3SYVA 4WPEA 5C5BA 3M3WA 1I4TA 4AVMA 1I49A 2YKTA 1Y2OA 1ZWWA 3ACOA 3QE6A 2D1LA 5C5BB 2C08A 3Q0KA
chains in the Genus database with same CATH superfamily
5E84A 2F18A 3QWEA 1QWUA 3O3OB 4EZOA 2GF4A 2YI8A 1O7DB 2F7PA 1HTYA 4EZRA 1MJGA 1HXKA 1X04A 4I1QA 2EX3B 1DKYA 1X03A 4EZNA 4JWDA 3T4AG 4IM3A 3ABHA 4NSWA 3DX0A 4R5KA 4ATMA 2OW6A 2RAIA 1I4LA 3CAZA 3CKDA 5TKYA 2D4CA 2EFKA 2LM0A 3B53X 2ND0A 3ER8C 3BUIA 3D2FA 3OHXM 4IWQA 3C7NA 3DYTA 3B51X 3QNJA 3HAIA 3GI7A 3L3OM 3RV0A 1SU6A 4R5LA 4FZPA 1ZYLA 3QA8A 3CZSA 4IM0A 2JNKA 2LXYA 2YLLA 3ACOA 4EZWA 4KIKB 5C5BB 3VEBA 1UPXA 4H8SA 2YL9A 1DKXA 2X3XA 4EZTA 2ND1A 2JNSA 1E2UA 1JQKA 4KIKA 5C5BA 3D4YA 1HWWA 1Y2OA 1LQ7A 4EZSA 3DX3A 5FIGA 3BVUA 4G6QA 4NQIA 3BUDA 3CV5A 1YWMA 3VEAA 2Z8YA 3FD9A 1GN9A 3BUBA 1TQUA 4NPHA 1QX1A 4UDYX 3QE6A 4AZBA 2YL5A 4EZYA 2V0OA 3DX2A 2Z0OA 1O7DC 3I2WA 1W9MA 4AZ6A 1OA0A 2RAKA 4HY9A 2F7OA 3EJQA 2OO2A 5KBPA 3DPPA 2FYVA 2PMRA 1U00A 4AZ5A 2GAFD 4IWOA 3DDGA 3BUQA 3HAHA 4R5JA 4HYBA 3BVVA 1WDZA 4DYLA 2Z0VA 3L3PA 3LVTA 3ER9B 4AVMA 3A98A 3EJUA 3I04A 4IWPA 4D8JA 4R5IA 4AKVA 2FICA 3I01A 4WPCA 3RV1A 2ALWA 4JLCA 4FZSA 4UDXX 2QXLA 4EZQA 2X5CA 2OBMA 4JWIA 3BVWA 3D51A 2YL6A 3DDFA 3BVTA 1I4DA 1GNLA 4F01A 2RAJA 2X3VA 4E3CA 1R5EA 1TQVA 2Q12A 2ZXQA 3D4ZA 4R5GA 3M3WA 3EJRA 2D1LA 2QKWA 3BUPA 5FLEX 3LMFA 2YL8A 1GNTA 2N3KA 4EZZA 3DPOA 4AZCB 2YIBA 1SU7A 1TQSA 3I39X 4JWCA 4EZPA 2EFLA 4AZ7A 3OK8A 4JNEA 2OZNB 2YKTA 2YIVX 4EZVA 4AZHA 4FM3A 3LLLA 3PLTA 3T46A 4AZIA 4HR1B 3F7WA 1E9VA 2ELBA 4M0MA 1E1DA 1URUA 2X3WA 4JNFA 1TQWA 1R33A 2YIAA 3O3MB 3O3NB 4E81A 4HR1A 2KHOA 2F7RA 3Q0KA 2F7QA 2WINM 2Q13A 3KAVA 3ZEDA 4IM2A 2F1BA 3BLBA 3T49A 2QFFA 2WYHA 3UITA 1OAOA 4BNEA 3KDRA 1TQTA 3T47A 3EJTA 3ERCC 4EZUA 2MI7A 3D52A 1DKZA 3SOGA 2YI9A 2WYIA 4JL9A 1R34A 3SYVA 1QWNA 3T48A 3DPQA 3D50A 3DX1A 4DCNC 3QNIA 3B52X 1SUFA 3VKHA 2OBLA 3HAJA 4H6IA 3EJPA 3CVRA 1I49A 4H6HA 3OWGA 3DX4A 3G9GA 1OA1A 2F1AA 2YLAA 3RPMA 3KAWA 4F00A 4B9QA 2RT6A 2OW7A 3D2EA 3EJSA 3Q84A 2O0I1 1SU8A 2PY6A 3CZNA 4WPEA 4AZGA 2NCZA 4AZCA 4PO2A 2Z0NA 4JWEA 4FZOA 4EZXA 2GA9D 1PS3A 3BVXA 4JN4A 1I4TA 4IW0A 1ZWWA 2EWFA 2C08A
chains in the Genus database with same CATH topology
3HAHA 4DCNC 2Z0NA 4H8SA 3LLLA 3QNIA 4BNEA 3DYTA 3PLTA 2X3XA 1X04A 3G9GA 4I1QA 2V0OA 1WDZA 2Z0OA 3I2WA 3HAIA 3QWEA 4NQIA 4DYLA 2ELBA 4AKVA 1I4DA 2FICA 2Q13A 2Z0VA 1X03A 3HAJA 2RAJA 2EFLA 2RAKA 2X3VA 4WPCA 3SOGA 3ABHA 4NSWA 2Q12A 3OK8A 2RAIA 4ATMA 1I4LA 1URUA 2X3WA 3CAZA 2D4CA 3Q84A 4FZSA 2EFKA 3SYVA 4WPEA 5C5BA 3M3WA 1I4TA 4AVMA 1I49A 2YKTA 1Y2OA 1ZWWA 3ACOA 3QE6A 2D1LA 5C5BB 2C08A 3Q0KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HAH A;  4DCN C;  2Z0N A;  4H8S A;  3LLL A;  3QNI A;  4BNE A;  3DYT A;  3PLT A;  2X3X A;  1X04 A;  3G9G A;  4I1Q A;  2V0O A;  1WDZ A;  2Z0O A;  3I2W A;  3HAI A;  3QWE A;  4NQI A;  4DYL A;  2ELB A;  4AKV A;  1I4D A;  2FIC A;  2Q13 A;  2Z0V A;  1X03 A;  3HAJ A;  2RAJ A;  2EFL A;  2RAK A;  2X3V A;  4WPC A;  3SOG A;  3ABH A;  4NSW A;  2Q12 A;  3OK8 A;  2RAI A;  4ATM A;  1I4L A;  1URU A;  2X3W A;  3CAZ A;  2D4C A;  3Q84 A;  4FZS A;  2EFK A;  3SYV A;  4WPE A;  5C5B A;  3M3W A;  1I4T A;  4AVM A;  1I49 A;  2YKT A;  1Y2O A;  1ZWW A;  3ACO A;  3QE6 A;  2D1L A;  5C5B B;  2C08 A;  3Q0K A; 
#chains in the Genus database with same CATH topology
 5E84 A;  2F18 A;  3QWE A;  1QWU A;  3O3O B;  4EZO A;  2GF4 A;  2YI8 A;  1O7D B;  2F7P A;  1HTY A;  4EZR A;  1MJG A;  1HXK A;  1X04 A;  4I1Q A;  2EX3 B;  1DKY A;  1X03 A;  4EZN A;  4JWD A;  3T4A G;  4IM3 A;  3ABH A;  4NSW A;  3DX0 A;  4R5K A;  4ATM A;  2OW6 A;  2RAI A;  1I4L A;  3CAZ A;  3CKD A;  5TKY A;  2D4C A;  2EFK A;  2LM0 A;  3B53 X;  2ND0 A;  3ER8 C;  3BUI A;  3D2F A;  3OHX M;  4IWQ A;  3C7N A;  3DYT A;  3B51 X;  3QNJ A;  3HAI A;  3GI7 A;  3L3O M;  3RV0 A;  1SU6 A;  4R5L A;  4FZP A;  1ZYL A;  3QA8 A;  3CZS A;  4IM0 A;  2JNK A;  2LXY A;  2YLL A;  3ACO A;  4EZW A;  4KIK B;  5C5B B;  3VEB A;  1UPX A;  4H8S A;  2YL9 A;  1DKX A;  2X3X A;  4EZT A;  2ND1 A;  2JNS A;  1E2U A;  1JQK A;  4KIK A;  5C5B A;  3D4Y A;  1HWW A;  1Y2O A;  1LQ7 A;  4EZS A;  3DX3 A;  5FIG A;  3BVU A;  4G6Q A;  4NQI A;  3BUD A;  3CV5 A;  1YWM A;  3VEA A;  2Z8Y A;  3FD9 A;  1GN9 A;  3BUB A;  1TQU A;  4NPH A;  1QX1 A;  4UDY X;  3QE6 A;  4AZB A;  2YL5 A;  4EZY A;  2V0O A;  3DX2 A;  2Z0O A;  1O7D C;  3I2W A;  1W9M A;  4AZ6 A;  1OA0 A;  2RAK A;  4HY9 A;  2F7O A;  3EJQ A;  2OO2 A;  5KBP A;  3DPP A;  2FYV A;  2PMR A;  1U00 A;  4AZ5 A;  2GAF D;  4IWO A;  3DDG A;  3BUQ A;  3HAH A;  4R5J A;  4HYB A;  3BVV A;  1WDZ A;  4DYL A;  2Z0V A;  3L3P A;  3LVT A;  3ER9 B;  4AVM A;  3A98 A;  3EJU A;  3I04 A;  4IWP A;  4D8J A;  4R5I A;  4AKV A;  2FIC A;  3I01 A;  4WPC A;  3RV1 A;  2ALW A;  4JLC A;  4FZS A;  4UDX X;  2QXL A;  4EZQ A;  2X5C A;  2OBM A;  4JWI A;  3BVW A;  3D51 A;  2YL6 A;  3DDF A;  3BVT A;  1I4D A;  1GNL A;  4F01 A;  2RAJ A;  2X3V A;  4E3C A;  1R5E A;  1TQV A;  2Q12 A;  2ZXQ A;  3D4Z A;  4R5G A;  3M3W A;  3EJR A;  2D1L A;  2QKW A;  3BUP A;  5FLE X;  3LMF A;  2YL8 A;  1GNT A;  2N3K A;  4EZZ A;  3DPO A;  4AZC B;  2YIB A;  1SU7 A;  1TQS A;  3I39 X;  4JWC A;  4EZP A;  2EFL A;  4AZ7 A;  3OK8 A;  4JNE A;  2OZN B;  2YKT A;  2YIV X;  4EZV A;  4AZH A;  4FM3 A;  3LLL A;  3PLT A;  3T46 A;  4AZI A;  4HR1 B;  3F7W A;  1E9V A;  2ELB A;  4M0M A;  1E1D A;  1URU A;  2X3W A;  4JNF A;  1TQW A;  1R33 A;  2YIA A;  3O3M B;  3O3N B;  4E81 A;  4HR1 A;  2KHO A;  2F7R A;  3Q0K A;  2F7Q A;  2WIN M;  2Q13 A;  3KAV A;  3ZED A;  4IM2 A;  2F1B A;  3BLB A;  3T49 A;  2QFF A;  2WYH A;  3UIT A;  1OAO A;  4BNE A;  3KDR A;  1TQT A;  3T47 A;  3EJT A;  3ERC C;  4EZU A;  2MI7 A;  3D52 A;  1DKZ A;  3SOG A;  2YI9 A;  2WYI A;  4JL9 A;  1R34 A;  3SYV A;  1QWN A;  3T48 A;  3DPQ A;  3D50 A;  3DX1 A;  4DCN C;  3QNI A;  3B52 X;  1SUF A;  3VKH A;  2OBL A;  3HAJ A;  4H6I A;  3EJP A;  3CVR A;  1I49 A;  4H6H A;  3OWG A;  3DX4 A;  3G9G A;  1OA1 A;  2F1A A;  2YLA A;  3RPM A;  3KAW A;  4F00 A;  4B9Q A;  2RT6 A;  2OW7 A;  3D2E A;  3EJS A;  3Q84 A;  2O0I 1;  1SU8 A;  2PY6 A;  3CZN A;  4WPE A;  4AZG A;  2NCZ A;  4AZC A;  4PO2 A;  2Z0N A;  4JWE A;  4FZO A;  4EZX A;  2GA9 D;  1PS3 A;  3BVX A;  4JN4 A;  1I4T A;  4IW0 A;  1ZWW A;  2EWF A;  2C08 A; 
#chains in the Genus database with same CATH homology
 3HAH A;  4DCN C;  2Z0N A;  4H8S A;  3LLL A;  3QNI A;  4BNE A;  3DYT A;  3PLT A;  2X3X A;  1X04 A;  3G9G A;  4I1Q A;  2V0O A;  1WDZ A;  2Z0O A;  3I2W A;  3HAI A;  3QWE A;  4NQI A;  4DYL A;  2ELB A;  4AKV A;  1I4D A;  2FIC A;  2Q13 A;  2Z0V A;  1X03 A;  3HAJ A;  2RAJ A;  2EFL A;  2RAK A;  2X3V A;  4WPC A;  3SOG A;  3ABH A;  4NSW A;  2Q12 A;  3OK8 A;  2RAI A;  4ATM A;  1I4L A;  1URU A;  2X3W A;  3CAZ A;  2D4C A;  3Q84 A;  4FZS A;  2EFK A;  3SYV A;  4WPE A;  5C5B A;  3M3W A;  1I4T A;  4AVM A;  1I49 A;  2YKT A;  1Y2O A;  1ZWW A;  3ACO A;  3QE6 A;  2D1L A;  5C5B B;  2C08 A;  3Q0K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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