1WDZA

Crystal structure of rcb domain of irsp53
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
231
structure length
231
Chain Sequence
SLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQGVDS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of RCB domain of IRSp53
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords insulin receptor substrate p53
total genus 112
structure length 231
sequence length 231
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-05-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1wdzA00
4AKVA 1X03A 2Q12A 2RAJA 3QWEA 2ELBA 3DYTA 3M3WA 2Q13A 3Q84A 3QE6A 4FZSA 3ABHA 3HAHA 4BNEA 1I49A 2D4CA 4AVMA 4WPCA 5C5BB 2Z0OA 3OK8A 4I1QA 3HAIA 2X3WA 2EFKA 3QNIA 4H8SA 1WDZA 2FICA 2RAKA 4NQIA 1I4DA 4ATMA 1Y2OA 1ZWWA 2EFLA 3PLTA 4DYLA 2YKTA 3ACOA 4WPEA 2Z0NA 2Z0VA 1I4LA 3CAZA 1X04A 2C08A 3LLLA 3Q0KA 3SYVA 4DCNC 2X3VA 4NSWA 5C5BA 3I2WA 2X3XA 2RAIA 2D1LA 2V0OA 1URUA 1I4TA 3HAJA 3SOGA 3G9GA
chains in the Genus database with same CATH superfamily
3HAHA 2ND0A 3ZEDA 1UPXA 2YLLA 3D2EA 4ATMA 4JL9A 1ZWWA 3RV1A 3O3NB 2F7QA 2F18A 2FYVA 3I04A 3LLLA 4NSWA 2Z8YA 2RAIA 1SU6A 3DX3A 4JNEA 1TQUA 1JQKA 4EZZA 4JWCA 3T48A 5C5BB 2F7RA 2X3WA 2EFKA 4M0MA 1I4DA 4R5JA 2ALWA 3KAWA 2GAFD 3T47A 1X04A 4AZCB 4DCNC 4EZVA 1E9VA 3B53X 3DDFA 3Q84A 1GNTA 3KAVA 2YIBA 3CV5A 4EZXA 3VEBA 4JN4A 4JWEA 2JNSA 2Z0VA 3DX1A 4H6HA 3G9GA 4R5LA 2OO2A 3BVUA 3I01A 4AZ5A 4H6IA 3UITA 5TKYA 2YIVX 2OBMA 3DPPA 3B51X 4IWQA 3T46A 3SYVA 5C5BA 3I39X 2D1LA 2WYIA 1OA0A 3BUPA 4EZQA 3O3MB 4R5KA 1OA1A 2Q12A 4EZTA 3OHXM 1QWNA 1W9MA 3D51A 2ZXQA 3QNIA 2YL6A 1Y2OA 4HR1A 4EZUA 4F00A 3CKDA 3DX0A 3HAJA 4IWPA 3SOGA 3FD9A 1X03A 4AKVA 3M3WA 2F7OA 3LVTA 1PS3A 4WPCA 2YI9A 4H8SA 3ER9B 1O7DB 2PMRA 4JWDA 4NQIA 2YKTA 3ACOA 4WPEA 1I4LA 3I2WA 1I4TA 3BUQA 3DYTA 4JWIA 2F1BA 1TQVA 2OBLA 1QX1A 3DX4A 4F01A 2N3KA 4UDYX 1GN9A 3PLTA 2O0I1 3EJQA 2X3VA 1TQWA 4D8JA 2ELBA 4IM0A 2QKWA 4HR1B 2ND1A 3DDGA 4R5IA 2YLAA 2Z0OA 3D52A 4B9QA 1HWWA 5E84A 3RPMA 2QFFA 2X3XA 3A98A 4NPHA 2YL8A 3CZSA 1DKXA 1R34A 4AZGA 3F7WA 1O7DC 3BVXA 5KBPA 3ER8C 3L3OM 2FICA 4UDXX 4AZ6A 1E2UA 2Z0NA 4EZPA 4R5GA 4KIKA 4HY9A 2OW7A 3D2FA 1R33A 1HXKA 2NCZA 1GNLA 3BVWA 2D4CA 4E3CA 3DPOA 2YL9A 4DYLA 2GA9D 1LQ7A 4EZOA 4FZOA 1ZYLA 3L3PA 4EZSA 2YI8A 4JNFA 1DKZA 4FZSA 4EZRA 1HTYA 4IW0A 4IWOA 4IM3A 2YIAA 3C7NA 2RT6A 2F7PA 2OZNB 3QA8A 4PO2A 3CZNA 1URUA 3BVVA 3QNJA 1DKYA 1TQSA 4AVMA 4KIKB 3VKHA 2KHOA 4FZPA 2RAKA 3KDRA 3EJPA 2WYHA 3ERCC 3T4AG 3DPQA 2X5CA 3D4YA 3GI7A 1SU8A 1YWMA 3BVTA 5FLEX 4BNEA 3EJSA 1QWUA 3OK8A 2MI7A 3HAIA 1SUFA 2OW6A 2F1AA 4AZ7A 3BUDA 5FIGA 2QXLA 2LM0A 3Q0KA 2V0OA 1E1DA 4AZHA 2Q13A 3QE6A 2PY6A 3ABHA 2EX3B 4G6QA 4AZIA 2LXYA 3EJUA 4I1QA 1WDZA 1R5EA 4EZYA 4JLCA 3LMFA 4E81A 4AZBA 4HYBA 2EFLA 1OAOA 2EWFA 3B52X 3RV0A 2C08A 3OWGA 3BUIA 2WINM 1TQTA 1I49A 4IM2A 3BUBA 3O3OB 1MJGA 1SU7A 2YL5A 3EJTA 3T49A 3VEAA 3BLBA 2RAJA 2JNKA 3QWEA 4EZWA 3D50A 3CVRA 4AZCA 3D4ZA 3DX2A 1U00A 2GF4A 3CAZA 4FM3A 4EZNA 3EJRA
chains in the Genus database with same CATH topology
4AKVA 1X03A 2Q12A 2RAJA 3QWEA 2ELBA 3DYTA 3M3WA 2Q13A 3Q84A 3QE6A 4FZSA 3ABHA 3HAHA 4BNEA 1I49A 2D4CA 4AVMA 4WPCA 5C5BB 2Z0OA 3OK8A 4I1QA 3HAIA 2X3WA 2EFKA 3QNIA 4H8SA 1WDZA 2FICA 2RAKA 4NQIA 1I4DA 4ATMA 1Y2OA 1ZWWA 2EFLA 3PLTA 4DYLA 2YKTA 3ACOA 4WPEA 2Z0NA 2Z0VA 1I4LA 3CAZA 1X04A 2C08A 3LLLA 3Q0KA 3SYVA 4DCNC 2X3VA 4NSWA 5C5BA 3I2WA 2X3XA 2RAIA 2D1LA 2V0OA 1URUA 1I4TA 3HAJA 3SOGA 3G9GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AKV A;  1X03 A;  2Q12 A;  2RAJ A;  3QWE A;  2ELB A;  3DYT A;  3M3W A;  2Q13 A;  3Q84 A;  3QE6 A;  4FZS A;  3ABH A;  3HAH A;  4BNE A;  1I49 A;  2D4C A;  4AVM A;  4WPC A;  5C5B B;  2Z0O A;  3OK8 A;  4I1Q A;  3HAI A;  2X3W A;  2EFK A;  3QNI A;  4H8S A;  1WDZ A;  2FIC A;  2RAK A;  4NQI A;  1I4D A;  4ATM A;  1Y2O A;  1ZWW A;  2EFL A;  3PLT A;  4DYL A;  2YKT A;  3ACO A;  4WPE A;  2Z0N A;  2Z0V A;  1I4L A;  3CAZ A;  1X04 A;  2C08 A;  3LLL A;  3Q0K A;  3SYV A;  4DCN C;  2X3V A;  4NSW A;  5C5B A;  3I2W A;  2X3X A;  2RAI A;  2D1L A;  2V0O A;  1URU A;  1I4T A;  3HAJ A;  3SOG A;  3G9G A; 
#chains in the Genus database with same CATH topology
 3HAH A;  2ND0 A;  3ZED A;  1UPX A;  2YLL A;  3D2E A;  4ATM A;  4JL9 A;  1ZWW A;  3RV1 A;  3O3N B;  2F7Q A;  2F18 A;  2FYV A;  3I04 A;  3LLL A;  4NSW A;  2Z8Y A;  2RAI A;  1SU6 A;  3DX3 A;  4JNE A;  1TQU A;  1JQK A;  4EZZ A;  4JWC A;  3T48 A;  5C5B B;  2F7R A;  2X3W A;  2EFK A;  4M0M A;  1I4D A;  4R5J A;  2ALW A;  3KAW A;  2GAF D;  3T47 A;  1X04 A;  4AZC B;  4DCN C;  4EZV A;  1E9V A;  3B53 X;  3DDF A;  3Q84 A;  1GNT A;  3KAV A;  2YIB A;  3CV5 A;  4EZX A;  3VEB A;  4JN4 A;  4JWE A;  2JNS A;  2Z0V A;  3DX1 A;  4H6H A;  3G9G A;  4R5L A;  2OO2 A;  3BVU A;  3I01 A;  4AZ5 A;  4H6I A;  3UIT A;  5TKY A;  2YIV X;  2OBM A;  3DPP A;  3B51 X;  4IWQ A;  3T46 A;  3SYV A;  5C5B A;  3I39 X;  2D1L A;  2WYI A;  1OA0 A;  3BUP A;  4EZQ A;  3O3M B;  4R5K A;  1OA1 A;  2Q12 A;  4EZT A;  3OHX M;  1QWN A;  1W9M A;  3D51 A;  2ZXQ A;  3QNI A;  2YL6 A;  1Y2O A;  4HR1 A;  4EZU A;  4F00 A;  3CKD A;  3DX0 A;  3HAJ A;  4IWP A;  3SOG A;  3FD9 A;  1X03 A;  4AKV A;  3M3W A;  2F7O A;  3LVT A;  1PS3 A;  4WPC A;  2YI9 A;  4H8S A;  3ER9 B;  1O7D B;  2PMR A;  4JWD A;  4NQI A;  2YKT A;  3ACO A;  4WPE A;  1I4L A;  3I2W A;  1I4T A;  3BUQ A;  3DYT A;  4JWI A;  2F1B A;  1TQV A;  2OBL A;  1QX1 A;  3DX4 A;  4F01 A;  2N3K A;  4UDY X;  1GN9 A;  3PLT A;  2O0I 1;  3EJQ A;  2X3V A;  1TQW A;  4D8J A;  2ELB A;  4IM0 A;  2QKW A;  4HR1 B;  2ND1 A;  3DDG A;  4R5I A;  2YLA A;  2Z0O A;  3D52 A;  4B9Q A;  1HWW A;  5E84 A;  3RPM A;  2QFF A;  2X3X A;  3A98 A;  4NPH A;  2YL8 A;  3CZS A;  1DKX A;  1R34 A;  4AZG A;  3F7W A;  1O7D C;  3BVX A;  5KBP A;  3ER8 C;  3L3O M;  2FIC A;  4UDX X;  4AZ6 A;  1E2U A;  2Z0N A;  4EZP A;  4R5G A;  4KIK A;  4HY9 A;  2OW7 A;  3D2F A;  1R33 A;  1HXK A;  2NCZ A;  1GNL A;  3BVW A;  2D4C A;  4E3C A;  3DPO A;  2YL9 A;  4DYL A;  2GA9 D;  1LQ7 A;  4EZO A;  4FZO A;  1ZYL A;  3L3P A;  4EZS A;  2YI8 A;  4JNF A;  1DKZ A;  4FZS A;  4EZR A;  1HTY A;  4IW0 A;  4IWO A;  4IM3 A;  2YIA A;  3C7N A;  2RT6 A;  2F7P A;  2OZN B;  3QA8 A;  4PO2 A;  3CZN A;  1URU A;  3BVV A;  3QNJ A;  1DKY A;  1TQS A;  4AVM A;  4KIK B;  3VKH A;  2KHO A;  4FZP A;  2RAK A;  3KDR A;  3EJP A;  2WYH A;  3ERC C;  3T4A G;  3DPQ A;  2X5C A;  3D4Y A;  3GI7 A;  1SU8 A;  1YWM A;  3BVT A;  5FLE X;  4BNE A;  3EJS A;  1QWU A;  3OK8 A;  2MI7 A;  3HAI A;  1SUF A;  2OW6 A;  2F1A A;  4AZ7 A;  3BUD A;  5FIG A;  2QXL A;  2LM0 A;  3Q0K A;  2V0O A;  1E1D A;  4AZH A;  2Q13 A;  3QE6 A;  2PY6 A;  3ABH A;  2EX3 B;  4G6Q A;  4AZI A;  2LXY A;  3EJU A;  4I1Q A;  1WDZ A;  1R5E A;  4EZY A;  4JLC A;  3LMF A;  4E81 A;  4AZB A;  4HYB A;  2EFL A;  1OAO A;  2EWF A;  3B52 X;  3RV0 A;  2C08 A;  3OWG A;  3BUI A;  2WIN M;  1TQT A;  1I49 A;  4IM2 A;  3BUB A;  3O3O B;  1MJG A;  1SU7 A;  2YL5 A;  3EJT A;  3T49 A;  3VEA A;  3BLB A;  2RAJ A;  2JNK A;  3QWE A;  4EZW A;  3D50 A;  3CVR A;  4AZC A;  3D4Z A;  3DX2 A;  1U00 A;  2GF4 A;  3CAZ A;  4FM3 A;  4EZN A;  3EJR A; 
#chains in the Genus database with same CATH homology
 4AKV A;  1X03 A;  2Q12 A;  2RAJ A;  3QWE A;  2ELB A;  3DYT A;  3M3W A;  2Q13 A;  3Q84 A;  3QE6 A;  4FZS A;  3ABH A;  3HAH A;  4BNE A;  1I49 A;  2D4C A;  4AVM A;  4WPC A;  5C5B B;  2Z0O A;  3OK8 A;  4I1Q A;  3HAI A;  2X3W A;  2EFK A;  3QNI A;  4H8S A;  1WDZ A;  2FIC A;  2RAK A;  4NQI A;  1I4D A;  4ATM A;  1Y2O A;  1ZWW A;  2EFL A;  3PLT A;  4DYL A;  2YKT A;  3ACO A;  4WPE A;  2Z0N A;  2Z0V A;  1I4L A;  3CAZ A;  1X04 A;  2C08 A;  3LLL A;  3Q0K A;  3SYV A;  4DCN C;  2X3V A;  4NSW A;  5C5B A;  3I2W A;  2X3X A;  2RAI A;  2D1L A;  2V0O A;  1URU A;  1I4T A;  3HAJ A;  3SOG A;  3G9G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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