1X03A

Crystal structure of endophilin bar domain
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
222
structure length
210
Chain Sequence
GTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMIPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords SH3-containing GRB2-like protein 2
total genus 79
structure length 210
sequence length 222
ec nomenclature ec 2.3.1.-:
pdb deposition date 2005-03-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03114 BAR BAR domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1x03A00
4DYLA 3ACOA 2Z0NA 3HAIA 3G9GA 2X3VA 4NQIA 3OK8A 3LLLA 2D4CA 2V0OA 3Q84A 4H8SA 1I4LA 3ABHA 3HAJA 3HAHA 2EFLA 2FICA 2Z0OA 1I4DA 1I49A 2Z0VA 2RAIA 3Q0KA 3QE6A 1URUA 2RAKA 2Q12A 4NSWA 5C5BA 1Y2OA 3SOGA 4WPEA 4FZSA 2Q13A 2RAJA 4WPCA 3PLTA 5C5BB 1I4TA 2ELBA 2YKTA 2X3WA 4AKVA 4ATMA 4BNEA 2X3XA 1WDZA 2D1LA 3QNIA 3SYVA 2EFKA 2C08A 1X03A 3M3WA 4AVMA 1X04A 1ZWWA 3QWEA 4DCNC 3I2WA 4I1QA 3DYTA 3CAZA
chains in the Genus database with same CATH superfamily
4NQIA 1YWMA 2FYVA 3DX3A 2F18A 3BVTA 2LM0A 3SOGA 3OWGA 4AZHA 3FD9A 2GA9D 4UDYX 3VEAA 5TKYA 3ACOA 4AZ6A 4HY9A 2OBLA 4M0MA 2GAFD 2Q13A 3T48A 4EZRA 4PO2A 2ND1A 1QWNA 2QFFA 3D2FA 2OW7A 2WINM 2YL8A 4R5LA 3BVXA 3I04A 3D4ZA 3EJPA 4JNFA 2LXYA 2Z0OA 1SUFA 3VEBA 3Q0KA 1QWUA 4IWPA 3PLTA 1DKYA 4E81A 2OO2A 3T46A 4R5GA 3D52A 2YIBA 3BUQA 4EZNA 3OHXM 1TQTA 1OAOA 3EJUA 2YL5A 4JWDA 4JWEA 3L3PA 4WPEA 2RAJA 4JL9A 4FM3A 1E9VA 4H6HA 3DPOA 3ERCC 4R5KA 3KDRA 4DYLA 3HAIA 2Z8YA 4D8JA 3GI7A 2YIVX 4JWIA 1I4LA 2OW6A 3HAHA 4IM3A 1I4DA 1I49A 4WPCA 4AZCA 4F00A 3DDGA 4UDXX 2D1LA 4EZVA 2MI7A 3I2WA 1DKXA 1R34A 3DX0A 4G6QA 3CKDA 4HR1A 3LMFA 5C5BB 2Z0NA 2YLLA 1GNTA 3KAVA 4IWOA 4EZYA 4IWQA 3EJQA 4EZQA 1R5EA 2YL6A 2YKTA 2YI9A 3QNIA 2C08A 1ZWWA 4EZSA 4EZXA 3T4AG 3ZEDA 3Q84A 3D2EA 2RAIA 1ZYLA 4FZPA 1I4TA 3ER8C 4AKVA 1R33A 1X03A 2ND0A 2NCZA 4B9QA 4AZCB 3LVTA 1MJGA 3DPQA 3BUBA 5C5BA 2O0I1 4IW0A 3BUIA 5KBPA 4HR1B 2X3XA 3O3OB 4AZIA 4AZ5A 1TQVA 1GN9A 2YLAA 4H8SA 4FZOA 2FICA 1DKZA 2OBMA 1QX1A 1W9MA 3SYVA 4DCNC 4H6IA 3D50A 4JLCA 3G9GA 3F7WA 1HWWA 2EFLA 2YI8A 3QE6A 2Q12A 2F7QA 1LQ7A 3L3OM 2ELBA 4ATMA 3ER9B 4AVMA 3DX4A 3UITA 3BVVA 2EWFA 3T47A 1SU6A 3QNJA 4KIKA 3CZSA 1TQUA 2QXLA 3KAWA 4FZSA 2EX3B 3EJRA 1E1DA 1OA1A 2X3WA 4BNEA 2ZXQA 1WDZA 3D4YA 1U00A 3BVWA 1OA0A 3CZNA 1O7DC 3DDFA 2ALWA 4NPHA 4AZ7A 1PS3A 2F1BA 2JNSA 2GF4A 3T49A 4IM0A 3EJSA 1TQWA 1GNLA 1SU8A 2D4CA 3BLBA 1URUA 2QKWA 1O7DB 3DPPA 3D51A 3B53X 5FIGA 2OZNB 3B51X 2N3KA 4R5JA 2RT6A 4I1QA 3DYTA 3CAZA 2F1AA 2YIAA 2WYHA 4IM2A 4KIKB 3RPMA 1UPXA 4E3CA 3LLLA 4JNEA 2WYIA 5FLEX 2F7RA 4F01A 3CVRA 1SU7A 4EZOA 1E2UA 4AZBA 1X04A 4HYBA 3VKHA 4EZTA 3BUDA 3C7NA 3QA8A 2X3VA 2KHOA 3I39X 2PY6A 2V0OA 4JWCA 3HAJA 4EZUA 4NSWA 1Y2OA 2PMRA 3A98A 4EZZA 1HTYA 1TQSA 3O3MB 2F7OA 4AZGA 3CV5A 2EFKA 3BUPA 3M3WA 3QWEA 1JQKA 1HXKA 4JN4A 2X5CA 3OK8A 3O3NB 3ABHA 3BVUA 2Z0VA 2RAKA 5E84A 4EZWA 3RV0A 2F7PA 3B52X 3I01A 4R5IA 2YL9A 4EZPA 3DX2A 3EJTA 3DX1A 3RV1A 2JNKA
chains in the Genus database with same CATH topology
4DYLA 3ACOA 2Z0NA 3HAIA 3G9GA 2X3VA 4NQIA 3OK8A 3LLLA 2D4CA 2V0OA 3Q84A 4H8SA 1I4LA 3ABHA 3HAJA 3HAHA 2EFLA 2FICA 2Z0OA 1I4DA 1I49A 2Z0VA 2RAIA 3Q0KA 3QE6A 1URUA 2RAKA 2Q12A 4NSWA 5C5BA 1Y2OA 3SOGA 4WPEA 4FZSA 2Q13A 2RAJA 4WPCA 3PLTA 5C5BB 1I4TA 2ELBA 2YKTA 2X3WA 4AKVA 4ATMA 4BNEA 2X3XA 1WDZA 2D1LA 3QNIA 3SYVA 2EFKA 2C08A 1X03A 3M3WA 4AVMA 1X04A 1ZWWA 3QWEA 4DCNC 3I2WA 4I1QA 3DYTA 3CAZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DYL A;  3ACO A;  2Z0N A;  3HAI A;  3G9G A;  2X3V A;  4NQI A;  3OK8 A;  3LLL A;  2D4C A;  2V0O A;  3Q84 A;  4H8S A;  1I4L A;  3ABH A;  3HAJ A;  3HAH A;  2EFL A;  2FIC A;  2Z0O A;  1I4D A;  1I49 A;  2Z0V A;  2RAI A;  3Q0K A;  3QE6 A;  1URU A;  2RAK A;  2Q12 A;  4NSW A;  5C5B A;  1Y2O A;  3SOG A;  4WPE A;  4FZS A;  2Q13 A;  2RAJ A;  4WPC A;  3PLT A;  5C5B B;  1I4T A;  2ELB A;  2YKT A;  2X3W A;  4AKV A;  4ATM A;  4BNE A;  2X3X A;  1WDZ A;  2D1L A;  3QNI A;  3SYV A;  2EFK A;  2C08 A;  1X03 A;  3M3W A;  4AVM A;  1X04 A;  1ZWW A;  3QWE A;  4DCN C;  3I2W A;  4I1Q A;  3DYT A;  3CAZ A; 
#chains in the Genus database with same CATH topology
 4NQI A;  1YWM A;  2FYV A;  3DX3 A;  2F18 A;  3BVT A;  2LM0 A;  3SOG A;  3OWG A;  4AZH A;  3FD9 A;  2GA9 D;  4UDY X;  3VEA A;  5TKY A;  3ACO A;  4AZ6 A;  4HY9 A;  2OBL A;  4M0M A;  2GAF D;  2Q13 A;  3T48 A;  4EZR A;  4PO2 A;  2ND1 A;  1QWN A;  2QFF A;  3D2F A;  2OW7 A;  2WIN M;  2YL8 A;  4R5L A;  3BVX A;  3I04 A;  3D4Z A;  3EJP A;  4JNF A;  2LXY A;  2Z0O A;  1SUF A;  3VEB A;  3Q0K A;  1QWU A;  4IWP A;  3PLT A;  1DKY A;  4E81 A;  2OO2 A;  3T46 A;  4R5G A;  3D52 A;  2YIB A;  3BUQ A;  4EZN A;  3OHX M;  1TQT A;  1OAO A;  3EJU A;  2YL5 A;  4JWD A;  4JWE A;  3L3P A;  4WPE A;  2RAJ A;  4JL9 A;  4FM3 A;  1E9V A;  4H6H A;  3DPO A;  3ERC C;  4R5K A;  3KDR A;  4DYL A;  3HAI A;  2Z8Y A;  4D8J A;  3GI7 A;  2YIV X;  4JWI A;  1I4L A;  2OW6 A;  3HAH A;  4IM3 A;  1I4D A;  1I49 A;  4WPC A;  4AZC A;  4F00 A;  3DDG A;  4UDX X;  2D1L A;  4EZV A;  2MI7 A;  3I2W A;  1DKX A;  1R34 A;  3DX0 A;  4G6Q A;  3CKD A;  4HR1 A;  3LMF A;  5C5B B;  2Z0N A;  2YLL A;  1GNT A;  3KAV A;  4IWO A;  4EZY A;  4IWQ A;  3EJQ A;  4EZQ A;  1R5E A;  2YL6 A;  2YKT A;  2YI9 A;  3QNI A;  2C08 A;  1ZWW A;  4EZS A;  4EZX A;  3T4A G;  3ZED A;  3Q84 A;  3D2E A;  2RAI A;  1ZYL A;  4FZP A;  1I4T A;  3ER8 C;  4AKV A;  1R33 A;  1X03 A;  2ND0 A;  2NCZ A;  4B9Q A;  4AZC B;  3LVT A;  1MJG A;  3DPQ A;  3BUB A;  5C5B A;  2O0I 1;  4IW0 A;  3BUI A;  5KBP A;  4HR1 B;  2X3X A;  3O3O B;  4AZI A;  4AZ5 A;  1TQV A;  1GN9 A;  2YLA A;  4H8S A;  4FZO A;  2FIC A;  1DKZ A;  2OBM A;  1QX1 A;  1W9M A;  3SYV A;  4DCN C;  4H6I A;  3D50 A;  4JLC A;  3G9G A;  3F7W A;  1HWW A;  2EFL A;  2YI8 A;  3QE6 A;  2Q12 A;  2F7Q A;  1LQ7 A;  3L3O M;  2ELB A;  4ATM A;  3ER9 B;  4AVM A;  3DX4 A;  3UIT A;  3BVV A;  2EWF A;  3T47 A;  1SU6 A;  3QNJ A;  4KIK A;  3CZS A;  1TQU A;  2QXL A;  3KAW A;  4FZS A;  2EX3 B;  3EJR A;  1E1D A;  1OA1 A;  2X3W A;  4BNE A;  2ZXQ A;  1WDZ A;  3D4Y A;  1U00 A;  3BVW A;  1OA0 A;  3CZN A;  1O7D C;  3DDF A;  2ALW A;  4NPH A;  4AZ7 A;  1PS3 A;  2F1B A;  2JNS A;  2GF4 A;  3T49 A;  4IM0 A;  3EJS A;  1TQW A;  1GNL A;  1SU8 A;  2D4C A;  3BLB A;  1URU A;  2QKW A;  1O7D B;  3DPP A;  3D51 A;  3B53 X;  5FIG A;  2OZN B;  3B51 X;  2N3K A;  4R5J A;  2RT6 A;  4I1Q A;  3DYT A;  3CAZ A;  2F1A A;  2YIA A;  2WYH A;  4IM2 A;  4KIK B;  3RPM A;  1UPX A;  4E3C A;  3LLL A;  4JNE A;  2WYI A;  5FLE X;  2F7R A;  4F01 A;  3CVR A;  1SU7 A;  4EZO A;  1E2U A;  4AZB A;  1X04 A;  4HYB A;  3VKH A;  4EZT A;  3BUD A;  3C7N A;  3QA8 A;  2X3V A;  2KHO A;  3I39 X;  2PY6 A;  2V0O A;  4JWC A;  3HAJ A;  4EZU A;  4NSW A;  1Y2O A;  2PMR A;  3A98 A;  4EZZ A;  1HTY A;  1TQS A;  3O3M B;  2F7O A;  4AZG A;  3CV5 A;  2EFK A;  3BUP A;  3M3W A;  3QWE A;  1JQK A;  1HXK A;  4JN4 A;  2X5C A;  3OK8 A;  3O3N B;  3ABH A;  3BVU A;  2Z0V A;  2RAK A;  5E84 A;  4EZW A;  3RV0 A;  2F7P A;  3B52 X;  3I01 A;  4R5I A;  2YL9 A;  4EZP A;  3DX2 A;  3EJT A;  3DX1 A;  3RV1 A;  2JNK A; 
#chains in the Genus database with same CATH homology
 4DYL A;  3ACO A;  2Z0N A;  3HAI A;  3G9G A;  2X3V A;  4NQI A;  3OK8 A;  3LLL A;  2D4C A;  2V0O A;  3Q84 A;  4H8S A;  1I4L A;  3ABH A;  3HAJ A;  3HAH A;  2EFL A;  2FIC A;  2Z0O A;  1I4D A;  1I49 A;  2Z0V A;  2RAI A;  3Q0K A;  3QE6 A;  1URU A;  2RAK A;  2Q12 A;  4NSW A;  5C5B A;  1Y2O A;  3SOG A;  4WPE A;  4FZS A;  2Q13 A;  2RAJ A;  4WPC A;  3PLT A;  5C5B B;  1I4T A;  2ELB A;  2YKT A;  2X3W A;  4AKV A;  4ATM A;  4BNE A;  2X3X A;  1WDZ A;  2D1L A;  3QNI A;  3SYV A;  2EFK A;  2C08 A;  1X03 A;  3M3W A;  4AVM A;  1X04 A;  1ZWW A;  3QWE A;  4DCN C;  3I2W A;  4I1Q A;  3DYT A;  3CAZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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