1X04A

Crystal structure of endophilin bar domain (mutant)
Total Genus 80
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
200
structure length
200
Chain Sequence
GTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLAHLSSLLQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords SH3-containing GRB2-like protein 2
total genus 80
structure length 200
sequence length 200
ec nomenclature ec 2.3.1.-:
pdb deposition date 2005-03-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03114 BAR BAR domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1x04A00
2Z0OA 4ATMA 4DCNC 4NQIA 5C5BA 2C08A 3QNIA 4WPEA 2Z0VA 1Y2OA 3G9GA 2YKTA 1X03A 1I49A 3HAJA 4WPCA 4BNEA 3CAZA 2Q13A 4I1QA 3QE6A 2EFKA 2ELBA 2RAIA 3HAIA 3ABHA 3DYTA 4AKVA 4AVMA 2EFLA 2D1LA 3ACOA 3SOGA 1X04A 1I4LA 3OK8A 3Q84A 4DYLA 2RAJA 4H8SA 3QWEA 5C5BB 2Z0NA 3HAHA 1WDZA 1I4DA 3LLLA 3M3WA 3PLTA 3SYVA 1I4TA 4NSWA 2X3VA 1ZWWA 2X3WA 2RAKA 4FZSA 3Q0KA 1URUA 2V0OA 3I2WA 2FICA 2Q12A 2D4CA 2X3XA
chains in the Genus database with same CATH superfamily
2ND1A 3BVUA 2WINM 4AZCA 4NQIA 3DX2A 3HAJA 4JLCA 4PO2A 3KAVA 2YLLA 2ALWA 3Q84A 2RT6A 2YIBA 4JN4A 3CZSA 2X3VA 2MI7A 4JWDA 3T48A 1SU6A 3GI7A 1I49A 1O7DB 3CV5A 4BNEA 4FM3A 4I1QA 4B9QA 2QKWA 3BUBA 3DDGA 4EZVA 3SYVA 1I4DA 3OWGA 4AZ7A 4NSWA 1E9VA 2OBLA 2Z0VA 4D8JA 2F1AA 4WPCA 3I39X 2OBMA 4KIKA 3RV0A 2KHOA 4EZQA 1DKXA 1U00A 5KBPA 1WDZA 3DX0A 1E2UA 3I2WA 4HYBA 4EZUA 2PY6A 2EWFA 3DX1A 4DCNC 4FZOA 3QNIA 1GN9A 2LXYA 4IM3A 3BUIA 1TQWA 2OO2A 1SUFA 3DPQA 1X04A 4AZCB 3QWEA 3VKHA 2GF4A 1HWWA 2YL8A 2JNSA 2YL9A 3D2FA 3D50A 5TKYA 4R5KA 3I01A 1X03A 4IWOA 3QE6A 4AVMA 3ACOA 1LQ7A 4R5IA 3EJTA 4EZPA 1O7DC 4M0MA 3BVTA 1URUA 3OHXM 4JWIA 2YI9A 1UPXA 2X3XA 2F7OA 4HR1A 4EZWA 1TQSA 1MJGA 3FD9A 2ELBA 4UDYX 3DYTA 3T47A 2ND0A 4NPHA 2QFFA 4EZZA 3C7NA 4KIKB 4UDXX 4EZTA 3T46A 4WPEA 3O3MB 2YIVX 1R34A 3OK8A 1GNLA 4F01A 1SU8A 1ZWWA 5E84A 1R5EA 3EJSA 1TQTA 1PS3A 2JNKA 2YL5A 2FYVA 3DX3A 3DPOA 3D4ZA 1TQVA 3RV1A 3B53X 2Q12A 3O3NB 1QX1A 3G9GA 1QWNA 3UITA 2X5CA 3VEBA 4EZOA 3BVWA 2OZNB 4FZPA 3ERCC 2EX3B 4R5LA 2F18A 2F7RA 3KAWA 1I4LA 4HR1B 4G6QA 2QXLA 4EZSA 3D51A 2WYHA 4E81A 2YL6A 1I4TA 3BUDA 4IM0A 1W9MA 3F7WA 1OA0A 2FICA 2YLAA 4JNEA 2Z8YA 1E1DA 3D52A 2LM0A 3ER9B 3BUPA 4AZ6A 3B52X 2OW6A 3ER8C 2D1LA 1OA1A 2Z0NA 3HAHA 3PLTA 4IM2A 4JWCA 3ZEDA 4H6IA 4ATMA 4IWPA 4R5JA 5C5BA 4AZIA 4JWEA 1HTYA 3EJUA 2ZXQA 3DX4A 2N3KA 4H8SA 3LLLA 1TQUA 3QNJA 1DKYA 1YWMA 3T4AG 4JL9A 3L3PA 3QA8A 2F7QA 1QWUA 4AKVA 3CVRA 3T49A 3M3WA 2O0I1 3B51X 1GNTA 3I04A 4EZYA 3KDRA 2F1BA 3CZNA 2Q13A 2RAIA 3DPPA 5FLEX 4F00A 3RPMA 3BVVA 3BVXA 2V0OA 2PMRA 1ZYLA 2GA9D 1DKZA 4JNFA 2WYIA 3A98A 1R33A 3CAZA 3BLBA 4EZNA 3EJPA 4EZRA 3ABHA 2OW7A 2EFLA 4AZBA 4AZHA 3DDFA 5C5BB 4EZXA 2RAKA 3LVTA 3BUQA 2Z0OA 3LMFA 4E3CA 1Y2OA 2YKTA 4R5GA 2YIAA 4AZ5A 2NCZA 4IW0A 3VEAA 1OAOA 1HXKA 4AZGA 1SU7A 3L3OM 4HY9A 2YI8A 3EJRA 5FIGA 2GAFD 3D4YA 3EJQA 2C08A 3CKDA 3D2EA 2F7PA 4IWQA 2EFKA 3HAIA 4H6HA 3SOGA 3O3OB 4DYLA 2RAJA 1JQKA 2X3WA 4FZSA 3Q0KA 2D4CA
chains in the Genus database with same CATH topology
2Z0OA 4ATMA 4DCNC 4NQIA 5C5BA 2C08A 3QNIA 4WPEA 2Z0VA 1Y2OA 3G9GA 2YKTA 1X03A 1I49A 3HAJA 4WPCA 4BNEA 3CAZA 2Q13A 4I1QA 3QE6A 2EFKA 2ELBA 2RAIA 3HAIA 3ABHA 3DYTA 4AKVA 4AVMA 2EFLA 2D1LA 3ACOA 3SOGA 1X04A 1I4LA 3OK8A 3Q84A 4DYLA 2RAJA 4H8SA 3QWEA 5C5BB 2Z0NA 3HAHA 1WDZA 1I4DA 3LLLA 3M3WA 3PLTA 3SYVA 1I4TA 4NSWA 2X3VA 1ZWWA 2X3WA 2RAKA 4FZSA 3Q0KA 1URUA 2V0OA 3I2WA 2FICA 2Q12A 2D4CA 2X3XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Z0O A;  4ATM A;  4DCN C;  4NQI A;  5C5B A;  2C08 A;  3QNI A;  4WPE A;  2Z0V A;  1Y2O A;  3G9G A;  2YKT A;  1X03 A;  1I49 A;  3HAJ A;  4WPC A;  4BNE A;  3CAZ A;  2Q13 A;  4I1Q A;  3QE6 A;  2EFK A;  2ELB A;  2RAI A;  3HAI A;  3ABH A;  3DYT A;  4AKV A;  4AVM A;  2EFL A;  2D1L A;  3ACO A;  3SOG A;  1X04 A;  1I4L A;  3OK8 A;  3Q84 A;  4DYL A;  2RAJ A;  4H8S A;  3QWE A;  5C5B B;  2Z0N A;  3HAH A;  1WDZ A;  1I4D A;  3LLL A;  3M3W A;  3PLT A;  3SYV A;  1I4T A;  4NSW A;  2X3V A;  1ZWW A;  2X3W A;  2RAK A;  4FZS A;  3Q0K A;  1URU A;  2V0O A;  3I2W A;  2FIC A;  2Q12 A;  2D4C A;  2X3X A; 
#chains in the Genus database with same CATH topology
 2ND1 A;  3BVU A;  2WIN M;  4AZC A;  4NQI A;  3DX2 A;  3HAJ A;  4JLC A;  4PO2 A;  3KAV A;  2YLL A;  2ALW A;  3Q84 A;  2RT6 A;  2YIB A;  4JN4 A;  3CZS A;  2X3V A;  2MI7 A;  4JWD A;  3T48 A;  1SU6 A;  3GI7 A;  1I49 A;  1O7D B;  3CV5 A;  4BNE A;  4FM3 A;  4I1Q A;  4B9Q A;  2QKW A;  3BUB A;  3DDG A;  4EZV A;  3SYV A;  1I4D A;  3OWG A;  4AZ7 A;  4NSW A;  1E9V A;  2OBL A;  2Z0V A;  4D8J A;  2F1A A;  4WPC A;  3I39 X;  2OBM A;  4KIK A;  3RV0 A;  2KHO A;  4EZQ A;  1DKX A;  1U00 A;  5KBP A;  1WDZ A;  3DX0 A;  1E2U A;  3I2W A;  4HYB A;  4EZU A;  2PY6 A;  2EWF A;  3DX1 A;  4DCN C;  4FZO A;  3QNI A;  1GN9 A;  2LXY A;  4IM3 A;  3BUI A;  1TQW A;  2OO2 A;  1SUF A;  3DPQ A;  1X04 A;  4AZC B;  3QWE A;  3VKH A;  2GF4 A;  1HWW A;  2YL8 A;  2JNS A;  2YL9 A;  3D2F A;  3D50 A;  5TKY A;  4R5K A;  3I01 A;  1X03 A;  4IWO A;  3QE6 A;  4AVM A;  3ACO A;  1LQ7 A;  4R5I A;  3EJT A;  4EZP A;  1O7D C;  4M0M A;  3BVT A;  1URU A;  3OHX M;  4JWI A;  2YI9 A;  1UPX A;  2X3X A;  2F7O A;  4HR1 A;  4EZW A;  1TQS A;  1MJG A;  3FD9 A;  2ELB A;  4UDY X;  3DYT A;  3T47 A;  2ND0 A;  4NPH A;  2QFF A;  4EZZ A;  3C7N A;  4KIK B;  4UDX X;  4EZT A;  3T46 A;  4WPE A;  3O3M B;  2YIV X;  1R34 A;  3OK8 A;  1GNL A;  4F01 A;  1SU8 A;  1ZWW A;  5E84 A;  1R5E A;  3EJS A;  1TQT A;  1PS3 A;  2JNK A;  2YL5 A;  2FYV A;  3DX3 A;  3DPO A;  3D4Z A;  1TQV A;  3RV1 A;  3B53 X;  2Q12 A;  3O3N B;  1QX1 A;  3G9G A;  1QWN A;  3UIT A;  2X5C A;  3VEB A;  4EZO A;  3BVW A;  2OZN B;  4FZP A;  3ERC C;  2EX3 B;  4R5L A;  2F18 A;  2F7R A;  3KAW A;  1I4L A;  4HR1 B;  4G6Q A;  2QXL A;  4EZS A;  3D51 A;  2WYH A;  4E81 A;  2YL6 A;  1I4T A;  3BUD A;  4IM0 A;  1W9M A;  3F7W A;  1OA0 A;  2FIC A;  2YLA A;  4JNE A;  2Z8Y A;  1E1D A;  3D52 A;  2LM0 A;  3ER9 B;  3BUP A;  4AZ6 A;  3B52 X;  2OW6 A;  3ER8 C;  2D1L A;  1OA1 A;  2Z0N A;  3HAH A;  3PLT A;  4IM2 A;  4JWC A;  3ZED A;  4H6I A;  4ATM A;  4IWP A;  4R5J A;  5C5B A;  4AZI A;  4JWE A;  1HTY A;  3EJU A;  2ZXQ A;  3DX4 A;  2N3K A;  4H8S A;  3LLL A;  1TQU A;  3QNJ A;  1DKY A;  1YWM A;  3T4A G;  4JL9 A;  3L3P A;  3QA8 A;  2F7Q A;  1QWU A;  4AKV A;  3CVR A;  3T49 A;  3M3W A;  2O0I 1;  3B51 X;  1GNT A;  3I04 A;  4EZY A;  3KDR A;  2F1B A;  3CZN A;  2Q13 A;  2RAI A;  3DPP A;  5FLE X;  4F00 A;  3RPM A;  3BVV A;  3BVX A;  2V0O A;  2PMR A;  1ZYL A;  2GA9 D;  1DKZ A;  4JNF A;  2WYI A;  3A98 A;  1R33 A;  3CAZ A;  3BLB A;  4EZN A;  3EJP A;  4EZR A;  3ABH A;  2OW7 A;  2EFL A;  4AZB A;  4AZH A;  3DDF A;  5C5B B;  4EZX A;  2RAK A;  3LVT A;  3BUQ A;  2Z0O A;  3LMF A;  4E3C A;  1Y2O A;  2YKT A;  4R5G A;  2YIA A;  4AZ5 A;  2NCZ A;  4IW0 A;  3VEA A;  1OAO A;  1HXK A;  4AZG A;  1SU7 A;  3L3O M;  4HY9 A;  2YI8 A;  3EJR A;  5FIG A;  2GAF D;  3D4Y A;  3EJQ A;  2C08 A;  3CKD A;  3D2E A;  2F7P A;  4IWQ A;  2EFK A;  3HAI A;  4H6H A;  3SOG A;  3O3O B;  4DYL A;  2RAJ A;  1JQK A;  2X3W A;  4FZS A;  3Q0K A;  2D4C A; 
#chains in the Genus database with same CATH homology
 2Z0O A;  4ATM A;  4DCN C;  4NQI A;  5C5B A;  2C08 A;  3QNI A;  4WPE A;  2Z0V A;  1Y2O A;  3G9G A;  2YKT A;  1X03 A;  1I49 A;  3HAJ A;  4WPC A;  4BNE A;  3CAZ A;  2Q13 A;  4I1Q A;  3QE6 A;  2EFK A;  2ELB A;  2RAI A;  3HAI A;  3ABH A;  3DYT A;  4AKV A;  4AVM A;  2EFL A;  2D1L A;  3ACO A;  3SOG A;  1X04 A;  1I4L A;  3OK8 A;  3Q84 A;  4DYL A;  2RAJ A;  4H8S A;  3QWE A;  5C5B B;  2Z0N A;  3HAH A;  1WDZ A;  1I4D A;  3LLL A;  3M3W A;  3PLT A;  3SYV A;  1I4T A;  4NSW A;  2X3V A;  1ZWW A;  2X3W A;  2RAK A;  4FZS A;  3Q0K A;  1URU A;  2V0O A;  3I2W A;  2FIC A;  2Q12 A;  2D4C A;  2X3X A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...