1X04A

Crystal structure of endophilin bar domain (mutant)
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
200
structure length
200
Chain Sequence
GTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLAHLSSLLQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords SH3-containing GRB2-like protein 2
total genus 80
structure length 200
sequence length 200
ec nomenclature ec 2.3.1.-:
pdb deposition date 2005-03-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03114 BAR BAR domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1x04A00
3DYTA 2Q12A 4I1QA 4NSWA 2YKTA 1I49A 1I4DA 3LLLA 4DYLA 4H8SA 2X3XA 5C5BB 2RAIA 2Z0NA 3CAZA 4WPCA 3QWEA 1I4LA 4DCNC 4FZSA 3Q0KA 3I2WA 2Z0VA 3HAIA 2EFLA 3QNIA 1I4TA 3OK8A 2ELBA 1ZWWA 1X03A 3ACOA 2EFKA 3G9GA 2V0OA 2Z0OA 2X3WA 3HAJA 3Q84A 3SOGA 3SYVA 1Y2OA 4BNEA 1X04A 2D1LA 4AKVA 5C5BA 2C08A 3M3WA 4NQIA 2Q13A 3QE6A 2RAKA 1URUA 3PLTA 3HAHA 1WDZA 2D4CA 2RAJA 2X3VA 4AVMA 4WPEA 2FICA 4ATMA 3ABHA
chains in the Genus database with same CATH superfamily
2RT6A 1R33A 3I01A 4R5GA 1OA1A 4JWEA 5FLEX 3T46A 2Z0NA 3DX4A 3T49A 2EWFA 4KIKA 3BVUA 4M0MA 3KAWA 2OW6A 1DKXA 1TQWA 3EJQA 3HAJA 3UITA 2F7QA 3CKDA 4AZ7A 2C08A 3M3WA 3BVTA 2YI9A 1QWNA 4FZPA 2GAFD 2LM0A 4IM3A 5E84A 1I4TA 2EFKA 2KHOA 1SU7A 2YIAA 3T47A 3D50A 2GA9D 5C5BB 2F18A 2YL9A 4IM2A 4IWPA 2Z0VA 2OO2A 4EZRA 3QNJA 1TQTA 2Z0OA 2LXYA 2PMRA 1QX1A 2ND0A 2ZXQA 1URUA 1SUFA 3B53X 3B52X 3BVWA 4I1QA 4JWIA 2YKTA 3LLLA 1E9VA 3QWEA 2Z8YA 2YL8A 2YI8A 3LMFA 1E2UA 4EZZA 1QWUA 3CVRA 4KIKB 2Q13A 3RV1A 3BUQA 2RAJA 4F01A 2F7PA 1DKYA 3CAZA 4R5JA 4WPCA 3I04A 4R5IA 2D1LA 1HWWA 4HYBA 3D51A 3QA8A 2F1AA 2NCZA 2RAKA 1WDZA 3B51X 4AZBA 4NSWA 4DYLA 1E1DA 4AZHA 1TQSA 1ZYLA 3BVXA 4JN4A 2YIBA 2OBMA 3OWGA 2F7RA 3ER8C 3D4ZA 4H6IA 2QFFA 2RAIA 3T48A 2PY6A 4EZPA 2JNKA 2EX3B 3ACOA 3Q84A 2YLAA 3QE6A 4E81A 3HAHA 3L3OM 4WPEA 2OBLA 1W9MA 4EZYA 3KDRA 4IWOA 1HXKA 4EZVA 5KBPA 1YWMA 3QNIA 1X03A 3C7NA 1GNTA 3BVVA 3DX0A 4AVMA 2Q12A 3DX2A 3KAVA 2YLLA 3BLBA 3RV0A 3EJPA 4JWCA 2OW7A 2YL6A 2ND1A 1PS3A 4FZSA 4EZWA 2EFLA 4AZIA 4AZ5A 2OZNB 4AZGA 2X3VA 4JLCA 2QKWA 4IWQA 4EZTA 2O0I1 4JNEA 2GF4A 3OK8A 2ELBA 1SU8A 3EJUA 3PLTA 3T4AG 3VEAA 3D2EA 4FM3A 4ATMA 1OAOA 2MI7A 3DYTA 3O3MB 1R5EA 3O3OB 1O7DC 3ZEDA 3A98A 3GI7A 4R5KA 4EZXA 3DPQA 2WYHA 4NPHA 3I39X 2QXLA 4NQIA 4AZCA 2JNSA 4D8JA 2ALWA 4UDYX 3DX3A 3DX1A 4HY9A 1JQKA 2X3XA 4HR1A 4IM0A 1I4LA 3Q0KA 4JL9A 3G9GA 2V0OA 2WYIA 3EJSA 4EZQA 1LQ7A 4UDXX 2X3WA 3ABHA 3DDFA 1I49A 3FD9A 1OA0A 4AZ6A 4JWDA 1HTYA 2F1BA 3BUBA 3I2WA 3DPOA 4EZNA 3D52A 3CV5A 3SOGA 1X04A 3ER9B 4AKVA 4EZOA 3LVTA 4EZUA 2YL5A 1TQVA 2FICA 3VEBA 4E3CA 3DPPA 3D2FA 4B9QA 2WINM 3ERCC 3O3NB 3EJTA 2F7OA 1ZWWA 3SYVA 2YIVX 1U00A 3BUDA 3BUIA 4R5LA 3EJRA 3VKHA 1GN9A 4AZCB 4DCNC 4IW0A 3CZSA 4BNEA 4HR1B 1TQUA 4FZOA 5C5BA 1O7DB 1GNLA 3DDGA 2FYVA 1DKZA 1I4DA 3RPMA 4H8SA 4G6QA 4PO2A 5TKYA 3CZNA 4JNFA 3L3PA 3HAIA 3OHXM 3F7WA 4EZSA 1SU6A 1R34A 3BUPA 1Y2OA 3D4YA 2N3KA 4F00A 5FIGA 1UPXA 4H6HA 2X5CA 2D4CA 1MJGA
chains in the Genus database with same CATH topology
3DYTA 2Q12A 4I1QA 4NSWA 2YKTA 1I49A 1I4DA 3LLLA 4DYLA 4H8SA 2X3XA 5C5BB 2RAIA 2Z0NA 3CAZA 4WPCA 3QWEA 1I4LA 4DCNC 4FZSA 3Q0KA 3I2WA 2Z0VA 3HAIA 2EFLA 3QNIA 1I4TA 3OK8A 2ELBA 1ZWWA 1X03A 3ACOA 2EFKA 3G9GA 2V0OA 2Z0OA 2X3WA 3HAJA 3Q84A 3SOGA 3SYVA 1Y2OA 4BNEA 1X04A 2D1LA 4AKVA 5C5BA 2C08A 3M3WA 4NQIA 2Q13A 3QE6A 2RAKA 1URUA 3PLTA 3HAHA 1WDZA 2D4CA 2RAJA 2X3VA 4AVMA 4WPEA 2FICA 4ATMA 3ABHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DYT A;  2Q12 A;  4I1Q A;  4NSW A;  2YKT A;  1I49 A;  1I4D A;  3LLL A;  4DYL A;  4H8S A;  2X3X A;  5C5B B;  2RAI A;  2Z0N A;  3CAZ A;  4WPC A;  3QWE A;  1I4L A;  4DCN C;  4FZS A;  3Q0K A;  3I2W A;  2Z0V A;  3HAI A;  2EFL A;  3QNI A;  1I4T A;  3OK8 A;  2ELB A;  1ZWW A;  1X03 A;  3ACO A;  2EFK A;  3G9G A;  2V0O A;  2Z0O A;  2X3W A;  3HAJ A;  3Q84 A;  3SOG A;  3SYV A;  1Y2O A;  4BNE A;  1X04 A;  2D1L A;  4AKV A;  5C5B A;  2C08 A;  3M3W A;  4NQI A;  2Q13 A;  3QE6 A;  2RAK A;  1URU A;  3PLT A;  3HAH A;  1WDZ A;  2D4C A;  2RAJ A;  2X3V A;  4AVM A;  4WPE A;  2FIC A;  4ATM A;  3ABH A; 
#chains in the Genus database with same CATH topology
 2RT6 A;  1R33 A;  3I01 A;  4R5G A;  1OA1 A;  4JWE A;  5FLE X;  3T46 A;  2Z0N A;  3DX4 A;  3T49 A;  2EWF A;  4KIK A;  3BVU A;  4M0M A;  3KAW A;  2OW6 A;  1DKX A;  1TQW A;  3EJQ A;  3HAJ A;  3UIT A;  2F7Q A;  3CKD A;  4AZ7 A;  2C08 A;  3M3W A;  3BVT A;  2YI9 A;  1QWN A;  4FZP A;  2GAF D;  2LM0 A;  4IM3 A;  5E84 A;  1I4T A;  2EFK A;  2KHO A;  1SU7 A;  2YIA A;  3T47 A;  3D50 A;  2GA9 D;  5C5B B;  2F18 A;  2YL9 A;  4IM2 A;  4IWP A;  2Z0V A;  2OO2 A;  4EZR A;  3QNJ A;  1TQT A;  2Z0O A;  2LXY A;  2PMR A;  1QX1 A;  2ND0 A;  2ZXQ A;  1URU A;  1SUF A;  3B53 X;  3B52 X;  3BVW A;  4I1Q A;  4JWI A;  2YKT A;  3LLL A;  1E9V A;  3QWE A;  2Z8Y A;  2YL8 A;  2YI8 A;  3LMF A;  1E2U A;  4EZZ A;  1QWU A;  3CVR A;  4KIK B;  2Q13 A;  3RV1 A;  3BUQ A;  2RAJ A;  4F01 A;  2F7P A;  1DKY A;  3CAZ A;  4R5J A;  4WPC A;  3I04 A;  4R5I A;  2D1L A;  1HWW A;  4HYB A;  3D51 A;  3QA8 A;  2F1A A;  2NCZ A;  2RAK A;  1WDZ A;  3B51 X;  4AZB A;  4NSW A;  4DYL A;  1E1D A;  4AZH A;  1TQS A;  1ZYL A;  3BVX A;  4JN4 A;  2YIB A;  2OBM A;  3OWG A;  2F7R A;  3ER8 C;  3D4Z A;  4H6I A;  2QFF A;  2RAI A;  3T48 A;  2PY6 A;  4EZP A;  2JNK A;  2EX3 B;  3ACO A;  3Q84 A;  2YLA A;  3QE6 A;  4E81 A;  3HAH A;  3L3O M;  4WPE A;  2OBL A;  1W9M A;  4EZY A;  3KDR A;  4IWO A;  1HXK A;  4EZV A;  5KBP A;  1YWM A;  3QNI A;  1X03 A;  3C7N A;  1GNT A;  3BVV A;  3DX0 A;  4AVM A;  2Q12 A;  3DX2 A;  3KAV A;  2YLL A;  3BLB A;  3RV0 A;  3EJP A;  4JWC A;  2OW7 A;  2YL6 A;  2ND1 A;  1PS3 A;  4FZS A;  4EZW A;  2EFL A;  4AZI A;  4AZ5 A;  2OZN B;  4AZG A;  2X3V A;  4JLC A;  2QKW A;  4IWQ A;  4EZT A;  2O0I 1;  4JNE A;  2GF4 A;  3OK8 A;  2ELB A;  1SU8 A;  3EJU A;  3PLT A;  3T4A G;  3VEA A;  3D2E A;  4FM3 A;  4ATM A;  1OAO A;  2MI7 A;  3DYT A;  3O3M B;  1R5E A;  3O3O B;  1O7D C;  3ZED A;  3A98 A;  3GI7 A;  4R5K A;  4EZX A;  3DPQ A;  2WYH A;  4NPH A;  3I39 X;  2QXL A;  4NQI A;  4AZC A;  2JNS A;  4D8J A;  2ALW A;  4UDY X;  3DX3 A;  3DX1 A;  4HY9 A;  1JQK A;  2X3X A;  4HR1 A;  4IM0 A;  1I4L A;  3Q0K A;  4JL9 A;  3G9G A;  2V0O A;  2WYI A;  3EJS A;  4EZQ A;  1LQ7 A;  4UDX X;  2X3W A;  3ABH A;  3DDF A;  1I49 A;  3FD9 A;  1OA0 A;  4AZ6 A;  4JWD A;  1HTY A;  2F1B A;  3BUB A;  3I2W A;  3DPO A;  4EZN A;  3D52 A;  3CV5 A;  3SOG A;  1X04 A;  3ER9 B;  4AKV A;  4EZO A;  3LVT A;  4EZU A;  2YL5 A;  1TQV A;  2FIC A;  3VEB A;  4E3C A;  3DPP A;  3D2F A;  4B9Q A;  2WIN M;  3ERC C;  3O3N B;  3EJT A;  2F7O A;  1ZWW A;  3SYV A;  2YIV X;  1U00 A;  3BUD A;  3BUI A;  4R5L A;  3EJR A;  3VKH A;  1GN9 A;  4AZC B;  4DCN C;  4IW0 A;  3CZS A;  4BNE A;  4HR1 B;  1TQU A;  4FZO A;  5C5B A;  1O7D B;  1GNL A;  3DDG A;  2FYV A;  1DKZ A;  1I4D A;  3RPM A;  4H8S A;  4G6Q A;  4PO2 A;  5TKY A;  3CZN A;  4JNF A;  3L3P A;  3HAI A;  3OHX M;  3F7W A;  4EZS A;  1SU6 A;  1R34 A;  3BUP A;  1Y2O A;  3D4Y A;  2N3K A;  4F00 A;  5FIG A;  1UPX A;  4H6H A;  2X5C A;  2D4C A;  1MJG A; 
#chains in the Genus database with same CATH homology
 3DYT A;  2Q12 A;  4I1Q A;  4NSW A;  2YKT A;  1I49 A;  1I4D A;  3LLL A;  4DYL A;  4H8S A;  2X3X A;  5C5B B;  2RAI A;  2Z0N A;  3CAZ A;  4WPC A;  3QWE A;  1I4L A;  4DCN C;  4FZS A;  3Q0K A;  3I2W A;  2Z0V A;  3HAI A;  2EFL A;  3QNI A;  1I4T A;  3OK8 A;  2ELB A;  1ZWW A;  1X03 A;  3ACO A;  2EFK A;  3G9G A;  2V0O A;  2Z0O A;  2X3W A;  3HAJ A;  3Q84 A;  3SOG A;  3SYV A;  1Y2O A;  4BNE A;  1X04 A;  2D1L A;  4AKV A;  5C5B A;  2C08 A;  3M3W A;  4NQI A;  2Q13 A;  3QE6 A;  2RAK A;  1URU A;  3PLT A;  3HAH A;  1WDZ A;  2D4C A;  2RAJ A;  2X3V A;  4AVM A;  4WPE A;  2FIC A;  4ATM A;  3ABH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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