1Y2OA

Structure of n-terminal domain irsp53/baiap2
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
248
structure length
248
Chain Sequence
MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords BAI1-associated protein 2 isoform 1
total genus 102
structure length 248
sequence length 248
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08397 IMD IRSp53/MIM homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1y2oA00
1I49A 2C08A 3HAJA 3Q0KA 2Q13A 2Z0OA 3HAIA 3QE6A 2RAJA 4BNEA 4AKVA 2YKTA 1X04A 3PLTA 3SYVA 1Y2OA 1I4DA 2Z0VA 4NQIA 4NSWA 1ZWWA 3CAZA 3DYTA 3LLLA 2Q12A 3M3WA 5C5BB 1I4LA 3HAHA 3G9GA 3Q84A 4WPCA 4ATMA 4AVMA 2EFLA 1X03A 2X3WA 3QNIA 1I4TA 3ABHA 4DCNC 2ELBA 2RAKA 2D1LA 1URUA 2Z0NA 4WPEA 4FZSA 5C5BA 2FICA 2D4CA 3QWEA 2X3VA 1WDZA 3I2WA 2V0OA 2RAIA 3ACOA 2X3XA 3OK8A 4H8SA 4I1QA 3SOGA 4DYLA 2EFKA
chains in the Genus database with same CATH superfamily
3QE6A 2GAFD 2YL8A 1HWWA 3KAVA 2F1AA 2RT6A 5C5BB 3Q84A 4B9QA 4EZXA 4DCNC 4AZ6A 4R5KA 1WDZA 2ND0A 3BVTA 4JL9A 3B53X 1JQKA 4BNEA 4UDXX 4IWPA 3LMFA 1QX1A 4KIKB 4FM3A 4JN4A 2F18A 2QXLA 3QNIA 4JWDA 5C5BA 2D4CA 1E2UA 2V0OA 2RAIA 1UPXA 2YL9A 1HXKA 3Q0KA 3EJTA 1Y2OA 4NQIA 4AZ7A 1TQTA 1ZWWA 3DYTA 4AZCB 4JWCA 2OW7A 2ZXQA 3GI7A 1DKYA 4KIKA 4E81A 3DX2A 3CZSA 4EZVA 1I49A 2O0I1 3KDRA 2Z0OA 4FZPA 3I39X 3BVXA 3HAHA 4AZGA 1X03A 4AZCA 1TQUA 2OW6A 3EJUA 3RV0A 3ZEDA 2Z0VA 3VEAA 2YI8A 2QFFA 4ATMA 1I4TA 3DX3A 3KAWA 4EZUA 2Z0NA 3L3PA 3VKHA 4H8SA 2JNSA 3HAJA 3B51X 3DX0A 1GNTA 3SYVA 3QA8A 3ER8C 4EZSA 4EZTA 3DPOA 3EJPA 3BLBA 3D2FA 1E9VA 3BVUA 3DX1A 2Q13A 3HAIA 3BVWA 3PLTA 2MI7A 2YL5A 2N3KA 1OA0A 4AZIA 5FIGA 3D52A 1R33A 2EFLA 3ER9B 3D50A 4AZBA 1R34A 2OBLA 1U00A 1O7DB 4F01A 3OK8A 1SU6A 2Z8YA 2RAJA 1OAOA 2ND1A 3CKDA 3OHXM 1DKXA 4IWOA 3O3NB 2FYVA 3D4ZA 4EZOA 2OZNB 2YIAA 3T47A 2F1BA 3A98A 3EJQA 3BVVA 2PMRA 1MJGA 3VEBA 1GNLA 3RPMA 3CV5A 4HR1B 3BUBA 4JLCA 2YLAA 3DPQA 1QWNA 4FZOA 3QNJA 2YIVX 4AKVA 1DKZA 2GF4A 4E3CA 2YL6A 1I4LA 2EWFA 3ABHA 2ELBA 3D2EA 4HYBA 1TQWA 5FLEX 2FICA 3DX4A 2PY6A 2X3VA 3O3MB 2F7QA 4IM0A 2C08A 1TQVA 2F7PA 2F7RA 3LVTA 4EZNA 4M0MA 1TQSA 4AZ5A 2ALWA 3T46A 4WPCA 4AVMA 2WYHA 1ZYLA 3EJRA 3CZNA 3BUQA 3ACOA 2EFKA 4IW0A 4JNFA 3BUPA 2QKWA 4EZQA 1I4DA 4EZZA 3BUIA 3T49A 3EJSA 4EZPA 4R5IA 4JNEA 4G6QA 4AZHA 4NPHA 3G9GA 1HTYA 3CVRA 3DPPA 4EZYA 3UITA 1YWMA 4R5GA 3I2WA 4H6HA 2X3XA 3D51A 4JWIA 4DYLA 3T4AG 2GA9D 5E84A 2JNKA 2YIBA 1W9MA 4EZRA 4IM2A 2X3WA 5KBPA 4PO2A 2NCZA 2LXYA 3SOGA 2X5CA 3F7WA 4IWQA 2YKTA 4R5JA 3LLLA 2Q12A 1LQ7A 3FD9A 3M3WA 2WYIA 4R5LA 3BUDA 2F7OA 3O3OB 4IM3A 3RV1A 4WPEA 2D1LA 1URUA 3T48A 1OA1A 2WINM 2YI9A 3DDGA 2EX3B 2LM0A 1PS3A 1X04A 4NSWA 3CAZA 5TKYA 1R5EA 2YLLA 1QWUA 4HY9A 3D4YA 4H6IA 1SU7A 3OWGA 4FZSA 3DDFA 1SUFA 3QWEA 1SU8A 4I1QA 1O7DC 4HR1A 2OO2A 1E1DA 3I01A 3ERCC 2KHOA 3C7NA 3B52X 4UDYX 3I04A 4F00A 1GN9A 2RAKA 4JWEA 4EZWA 2OBMA 4D8JA 3L3OM
chains in the Genus database with same CATH topology
1I49A 2C08A 3HAJA 3Q0KA 2Q13A 2Z0OA 3HAIA 3QE6A 2RAJA 4BNEA 4AKVA 2YKTA 1X04A 3PLTA 3SYVA 1Y2OA 1I4DA 2Z0VA 4NQIA 4NSWA 1ZWWA 3CAZA 3DYTA 3LLLA 2Q12A 3M3WA 5C5BB 1I4LA 3HAHA 3G9GA 3Q84A 4WPCA 4ATMA 4AVMA 2EFLA 1X03A 2X3WA 3QNIA 1I4TA 3ABHA 4DCNC 2ELBA 2RAKA 2D1LA 1URUA 2Z0NA 4WPEA 4FZSA 5C5BA 2FICA 2D4CA 3QWEA 2X3VA 1WDZA 3I2WA 2V0OA 2RAIA 3ACOA 2X3XA 3OK8A 4H8SA 4I1QA 3SOGA 4DYLA 2EFKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I49 A;  2C08 A;  3HAJ A;  3Q0K A;  2Q13 A;  2Z0O A;  3HAI A;  3QE6 A;  2RAJ A;  4BNE A;  4AKV A;  2YKT A;  1X04 A;  3PLT A;  3SYV A;  1Y2O A;  1I4D A;  2Z0V A;  4NQI A;  4NSW A;  1ZWW A;  3CAZ A;  3DYT A;  3LLL A;  2Q12 A;  3M3W A;  5C5B B;  1I4L A;  3HAH A;  3G9G A;  3Q84 A;  4WPC A;  4ATM A;  4AVM A;  2EFL A;  1X03 A;  2X3W A;  3QNI A;  1I4T A;  3ABH A;  4DCN C;  2ELB A;  2RAK A;  2D1L A;  1URU A;  2Z0N A;  4WPE A;  4FZS A;  5C5B A;  2FIC A;  2D4C A;  3QWE A;  2X3V A;  1WDZ A;  3I2W A;  2V0O A;  2RAI A;  3ACO A;  2X3X A;  3OK8 A;  4H8S A;  4I1Q A;  3SOG A;  4DYL A;  2EFK A; 
#chains in the Genus database with same CATH topology
 3QE6 A;  2GAF D;  2YL8 A;  1HWW A;  3KAV A;  2F1A A;  2RT6 A;  5C5B B;  3Q84 A;  4B9Q A;  4EZX A;  4DCN C;  4AZ6 A;  4R5K A;  1WDZ A;  2ND0 A;  3BVT A;  4JL9 A;  3B53 X;  1JQK A;  4BNE A;  4UDX X;  4IWP A;  3LMF A;  1QX1 A;  4KIK B;  4FM3 A;  4JN4 A;  2F18 A;  2QXL A;  3QNI A;  4JWD A;  5C5B A;  2D4C A;  1E2U A;  2V0O A;  2RAI A;  1UPX A;  2YL9 A;  1HXK A;  3Q0K A;  3EJT A;  1Y2O A;  4NQI A;  4AZ7 A;  1TQT A;  1ZWW A;  3DYT A;  4AZC B;  4JWC A;  2OW7 A;  2ZXQ A;  3GI7 A;  1DKY A;  4KIK A;  4E81 A;  3DX2 A;  3CZS A;  4EZV A;  1I49 A;  2O0I 1;  3KDR A;  2Z0O A;  4FZP A;  3I39 X;  3BVX A;  3HAH A;  4AZG A;  1X03 A;  4AZC A;  1TQU A;  2OW6 A;  3EJU A;  3RV0 A;  3ZED A;  2Z0V A;  3VEA A;  2YI8 A;  2QFF A;  4ATM A;  1I4T A;  3DX3 A;  3KAW A;  4EZU A;  2Z0N A;  3L3P A;  3VKH A;  4H8S A;  2JNS A;  3HAJ A;  3B51 X;  3DX0 A;  1GNT A;  3SYV A;  3QA8 A;  3ER8 C;  4EZS A;  4EZT A;  3DPO A;  3EJP A;  3BLB A;  3D2F A;  1E9V A;  3BVU A;  3DX1 A;  2Q13 A;  3HAI A;  3BVW A;  3PLT A;  2MI7 A;  2YL5 A;  2N3K A;  1OA0 A;  4AZI A;  5FIG A;  3D52 A;  1R33 A;  2EFL A;  3ER9 B;  3D50 A;  4AZB A;  1R34 A;  2OBL A;  1U00 A;  1O7D B;  4F01 A;  3OK8 A;  1SU6 A;  2Z8Y A;  2RAJ A;  1OAO A;  2ND1 A;  3CKD A;  3OHX M;  1DKX A;  4IWO A;  3O3N B;  2FYV A;  3D4Z A;  4EZO A;  2OZN B;  2YIA A;  3T47 A;  2F1B A;  3A98 A;  3EJQ A;  3BVV A;  2PMR A;  1MJG A;  3VEB A;  1GNL A;  3RPM A;  3CV5 A;  4HR1 B;  3BUB A;  4JLC A;  2YLA A;  3DPQ A;  1QWN A;  4FZO A;  3QNJ A;  2YIV X;  4AKV A;  1DKZ A;  2GF4 A;  4E3C A;  2YL6 A;  1I4L A;  2EWF A;  3ABH A;  2ELB A;  3D2E A;  4HYB A;  1TQW A;  5FLE X;  2FIC A;  3DX4 A;  2PY6 A;  2X3V A;  3O3M B;  2F7Q A;  4IM0 A;  2C08 A;  1TQV A;  2F7P A;  2F7R A;  3LVT A;  4EZN A;  4M0M A;  1TQS A;  4AZ5 A;  2ALW A;  3T46 A;  4WPC A;  4AVM A;  2WYH A;  1ZYL A;  3EJR A;  3CZN A;  3BUQ A;  3ACO A;  2EFK A;  4IW0 A;  4JNF A;  3BUP A;  2QKW A;  4EZQ A;  1I4D A;  4EZZ A;  3BUI A;  3T49 A;  3EJS A;  4EZP A;  4R5I A;  4JNE A;  4G6Q A;  4AZH A;  4NPH A;  3G9G A;  1HTY A;  3CVR A;  3DPP A;  4EZY A;  3UIT A;  1YWM A;  4R5G A;  3I2W A;  4H6H A;  2X3X A;  3D51 A;  4JWI A;  4DYL A;  3T4A G;  2GA9 D;  5E84 A;  2JNK A;  2YIB A;  1W9M A;  4EZR A;  4IM2 A;  2X3W A;  5KBP A;  4PO2 A;  2NCZ A;  2LXY A;  3SOG A;  2X5C A;  3F7W A;  4IWQ A;  2YKT A;  4R5J A;  3LLL A;  2Q12 A;  1LQ7 A;  3FD9 A;  3M3W A;  2WYI A;  4R5L A;  3BUD A;  2F7O A;  3O3O B;  4IM3 A;  3RV1 A;  4WPE A;  2D1L A;  1URU A;  3T48 A;  1OA1 A;  2WIN M;  2YI9 A;  3DDG A;  2EX3 B;  2LM0 A;  1PS3 A;  1X04 A;  4NSW A;  3CAZ A;  5TKY A;  1R5E A;  2YLL A;  1QWU A;  4HY9 A;  3D4Y A;  4H6I A;  1SU7 A;  3OWG A;  4FZS A;  3DDF A;  1SUF A;  3QWE A;  1SU8 A;  4I1Q A;  1O7D C;  4HR1 A;  2OO2 A;  1E1D A;  3I01 A;  3ERC C;  2KHO A;  3C7N A;  3B52 X;  4UDY X;  3I04 A;  4F00 A;  1GN9 A;  2RAK A;  4JWE A;  4EZW A;  2OBM A;  4D8J A;  3L3O M; 
#chains in the Genus database with same CATH homology
 1I49 A;  2C08 A;  3HAJ A;  3Q0K A;  2Q13 A;  2Z0O A;  3HAI A;  3QE6 A;  2RAJ A;  4BNE A;  4AKV A;  2YKT A;  1X04 A;  3PLT A;  3SYV A;  1Y2O A;  1I4D A;  2Z0V A;  4NQI A;  4NSW A;  1ZWW A;  3CAZ A;  3DYT A;  3LLL A;  2Q12 A;  3M3W A;  5C5B B;  1I4L A;  3HAH A;  3G9G A;  3Q84 A;  4WPC A;  4ATM A;  4AVM A;  2EFL A;  1X03 A;  2X3W A;  3QNI A;  1I4T A;  3ABH A;  4DCN C;  2ELB A;  2RAK A;  2D1L A;  1URU A;  2Z0N A;  4WPE A;  4FZS A;  5C5B A;  2FIC A;  2D4C A;  3QWE A;  2X3V A;  1WDZ A;  3I2W A;  2V0O A;  2RAI A;  3ACO A;  2X3X A;  3OK8 A;  4H8S A;  4I1Q A;  3SOG A;  4DYL A;  2EFK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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