1I49A

Crystal structure analysis of arfaptin
Total Genus 97
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
97
sequence length
201
structure length
201
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 97
structure length 201
sequence length 201
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i49A00
3G9GA 3HAIA 4NSWA 5C5BA 4DCNC 2ELBA 2X3WA 2Z0OA 3PLTA 4AKVA 1Y2OA 4BNEA 3HAHA 3LLLA 1I4LA 2RAIA 1WDZA 3Q84A 2D1LA 2Q13A 3I2WA 3QNIA 2D4CA 3QE6A 1ZWWA 3ABHA 3ACOA 3OK8A 1I4TA 2FICA 2X3VA 3M3WA 2RAJA 3DYTA 3QWEA 4NQIA 3SYVA 4WPEA 1URUA 3CAZA 4DYLA 3SOGA 4WPCA 4AVMA 1X03A 1I49A 1I4DA 2X3XA 3Q0KA 2EFLA 4I1QA 4H8SA 2Z0VA 2Q12A 2V0OA 3HAJA 4FZSA 2EFKA 4ATMA 5C5BB 1X04A 2C08A 2Z0NA 2YKTA 2RAKA
chains in the Genus database with same CATH superfamily
3ER9B 4JWIA 1QX1A 2GAFD 1I4LA 3OHXM 4AZHA 3BUDA 4D8JA 3BUBA 3OK8A 3BVUA 2FICA 1GNLA 4H8SA 3ER8C 4R5GA 1O7DC 3LVTA 4F01A 3BLBA 4JN4A 1WDZA 1QWNA 3Q84A 4AZCB 3OWGA 3T47A 1ZWWA 3VEAA 4JWEA 3I04A 3B53X 3SYVA 4EZZA 1TQWA 4AVMA 3DPOA 4AZGA 2EFKA 4PO2A 4M0MA 4BNEA 2F1BA 4FZOA 3VKHA 1TQTA 3DX0A 2GF4A 3DX3A 4HR1B 3D2FA 2X3VA 4HYBA 3O3OB 5FLEX 4I1QA 4JL9A 5TKYA 2RAKA 3ACOA 4NPHA 3D52A 4NSWA 4IWQA 3I39X 4JNEA 3CV5A 4R5JA 2D1LA 2EX3B 4JLCA 4EZPA 2YIAA 2PMRA 1R5EA 4WPCA 1I4DA 4IM3A 3D2EA 2LM0A 2YLLA 1SU6A 4EZUA 3EJPA 3T48A 4KIKB 3BVWA 2YI9A 2N3KA 3EJTA 3KAWA 3DX1A 3GI7A 2OZNB 4EZVA 2EWFA 3B52X 3KDRA 5C5BB 2JNSA 1Y2OA 2YL5A 4AZBA 3L3PA 2YL8A 2GA9D 1OA0A 4WPEA 3D4ZA 4UDXX 1URUA 3SOGA 3BUPA 1I49A 2ND0A 1R34A 3DX2A 4JNFA 3EJSA 2F18A 3BVVA 4AKVA 1HXKA 2D4CA 4AZ5A 1HTYA 3LMFA 4IM0A 3T46A 3BVXA 3I01A 3CVRA 2ELBA 1TQVA 3O3MB 3FD9A 2F7PA 2O0I1 2YI8A 3D4YA 1JQKA 3RV1A 2QFFA 2QKWA 3QWEA 3B51X 3CZNA 2F7RA 2Q12A 2YIBA 4AZ7A 3CZSA 2RT6A 2C08A 4JWDA 1ZYLA 1UPXA 2Z0OA 4IW0A 2OO2A 2ALWA 4EZYA 3I2WA 1DKZA 2PY6A 3ABHA 4EZWA 3DYTA 3EJQA 4EZOA 5KBPA 1E1DA 2ZXQA 2YKTA 1MJGA 2ND1A 2YL6A 2JNKA 4EZQA 4DCNC 1W9MA 5E84A 2WYHA 2FYVA 1I4TA 4NQIA 4FM3A 3A98A 3O3NB 3Q0KA 1O7DB 4E81A 1PS3A 3DDFA 1SUFA 3ERCC 2WYIA 5C5BA 3PLTA 3RV0A 4F00A 2X5CA 3D50A 3LLLA 1LQ7A 3D51A 3KAVA 2OW6A 2RAIA 2Q13A 2F7QA 1TQUA 3F7WA 3EJRA 3DPQA 2F1AA 2OW7A 1R33A 4EZNA 4FZPA 4HY9A 1YWMA 4R5IA 3CKDA 1DKXA 4H6IA 4EZXA 2X3WA 2WINM 1U00A 4G6QA 3QE6A 4AZCA 2RAJA 3BVTA 3QA8A 2KHOA 4EZTA 1OA1A 1X04A 2OBLA 2Z0NA 3HAIA 3T4AG 4H6HA 2YLAA 3DPPA 4JWCA 2QXLA 3DX4A 1GN9A 3DDGA 2F7OA 3M3WA 4R5LA 3CAZA 4DYLA 2LXYA 4HR1A 2EFLA 3EJUA 2Z0VA 1HWWA 4FZSA 5FIGA 3G9GA 4IM2A 1E2UA 2Z8YA 3C7NA 2YL9A 3QNJA 3HAJA 3T49A 4R5KA 2OBMA 4ATMA 3RPMA 3L3OM 3BUIA 1GNTA 3UITA 3VEBA 2MI7A 4AZIA 4AZ6A 3QNIA 4KIKA 3ZEDA 4EZRA 4UDYX 4IWPA 1DKYA 4EZSA 1X03A 2X3XA 2V0OA 2NCZA 1E9VA 1QWUA 1SU8A 2YIVX 1TQSA 1OAOA 4IWOA 1SU7A 4B9QA 3HAHA 4E3CA 3BUQA
chains in the Genus database with same CATH topology
3G9GA 3HAIA 4NSWA 5C5BA 4DCNC 2ELBA 2X3WA 2Z0OA 3PLTA 4AKVA 1Y2OA 4BNEA 3HAHA 3LLLA 1I4LA 2RAIA 1WDZA 3Q84A 2D1LA 2Q13A 3I2WA 3QNIA 2D4CA 3QE6A 1ZWWA 3ABHA 3ACOA 3OK8A 1I4TA 2FICA 2X3VA 3M3WA 2RAJA 3DYTA 3QWEA 4NQIA 3SYVA 4WPEA 1URUA 3CAZA 4DYLA 3SOGA 4WPCA 4AVMA 1X03A 1I49A 1I4DA 2X3XA 3Q0KA 2EFLA 4I1QA 4H8SA 2Z0VA 2Q12A 2V0OA 3HAJA 4FZSA 2EFKA 4ATMA 5C5BB 1X04A 2C08A 2Z0NA 2YKTA 2RAKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3G9G A;  3HAI A;  4NSW A;  5C5B A;  4DCN C;  2ELB A;  2X3W A;  2Z0O A;  3PLT A;  4AKV A;  1Y2O A;  4BNE A;  3HAH A;  3LLL A;  1I4L A;  2RAI A;  1WDZ A;  3Q84 A;  2D1L A;  2Q13 A;  3I2W A;  3QNI A;  2D4C A;  3QE6 A;  1ZWW A;  3ABH A;  3ACO A;  3OK8 A;  1I4T A;  2FIC A;  2X3V A;  3M3W A;  2RAJ A;  3DYT A;  3QWE A;  4NQI A;  3SYV A;  4WPE A;  1URU A;  3CAZ A;  4DYL A;  3SOG A;  4WPC A;  4AVM A;  1X03 A;  1I49 A;  1I4D A;  2X3X A;  3Q0K A;  2EFL A;  4I1Q A;  4H8S A;  2Z0V A;  2Q12 A;  2V0O A;  3HAJ A;  4FZS A;  2EFK A;  4ATM A;  5C5B B;  1X04 A;  2C08 A;  2Z0N A;  2YKT A;  2RAK A; 
#chains in the Genus database with same CATH topology
 3ER9 B;  4JWI A;  1QX1 A;  2GAF D;  1I4L A;  3OHX M;  4AZH A;  3BUD A;  4D8J A;  3BUB A;  3OK8 A;  3BVU A;  2FIC A;  1GNL A;  4H8S A;  3ER8 C;  4R5G A;  1O7D C;  3LVT A;  4F01 A;  3BLB A;  4JN4 A;  1WDZ A;  1QWN A;  3Q84 A;  4AZC B;  3OWG A;  3T47 A;  1ZWW A;  3VEA A;  4JWE A;  3I04 A;  3B53 X;  3SYV A;  4EZZ A;  1TQW A;  4AVM A;  3DPO A;  4AZG A;  2EFK A;  4PO2 A;  4M0M A;  4BNE A;  2F1B A;  4FZO A;  3VKH A;  1TQT A;  3DX0 A;  2GF4 A;  3DX3 A;  4HR1 B;  3D2F A;  2X3V A;  4HYB A;  3O3O B;  5FLE X;  4I1Q A;  4JL9 A;  5TKY A;  2RAK A;  3ACO A;  4NPH A;  3D52 A;  4NSW A;  4IWQ A;  3I39 X;  4JNE A;  3CV5 A;  4R5J A;  2D1L A;  2EX3 B;  4JLC A;  4EZP A;  2YIA A;  2PMR A;  1R5E A;  4WPC A;  1I4D A;  4IM3 A;  3D2E A;  2LM0 A;  2YLL A;  1SU6 A;  4EZU A;  3EJP A;  3T48 A;  4KIK B;  3BVW A;  2YI9 A;  2N3K A;  3EJT A;  3KAW A;  3DX1 A;  3GI7 A;  2OZN B;  4EZV A;  2EWF A;  3B52 X;  3KDR A;  5C5B B;  2JNS A;  1Y2O A;  2YL5 A;  4AZB A;  3L3P A;  2YL8 A;  2GA9 D;  1OA0 A;  4WPE A;  3D4Z A;  4UDX X;  1URU A;  3SOG A;  3BUP A;  1I49 A;  2ND0 A;  1R34 A;  3DX2 A;  4JNF A;  3EJS A;  2F18 A;  3BVV A;  4AKV A;  1HXK A;  2D4C A;  4AZ5 A;  1HTY A;  3LMF A;  4IM0 A;  3T46 A;  3BVX A;  3I01 A;  3CVR A;  2ELB A;  1TQV A;  3O3M B;  3FD9 A;  2F7P A;  2O0I 1;  2YI8 A;  3D4Y A;  1JQK A;  3RV1 A;  2QFF A;  2QKW A;  3QWE A;  3B51 X;  3CZN A;  2F7R A;  2Q12 A;  2YIB A;  4AZ7 A;  3CZS A;  2RT6 A;  2C08 A;  4JWD A;  1ZYL A;  1UPX A;  2Z0O A;  4IW0 A;  2OO2 A;  2ALW A;  4EZY A;  3I2W A;  1DKZ A;  2PY6 A;  3ABH A;  4EZW A;  3DYT A;  3EJQ A;  4EZO A;  5KBP A;  1E1D A;  2ZXQ A;  2YKT A;  1MJG A;  2ND1 A;  2YL6 A;  2JNK A;  4EZQ A;  4DCN C;  1W9M A;  5E84 A;  2WYH A;  2FYV A;  1I4T A;  4NQI A;  4FM3 A;  3A98 A;  3O3N B;  3Q0K A;  1O7D B;  4E81 A;  1PS3 A;  3DDF A;  1SUF A;  3ERC C;  2WYI A;  5C5B A;  3PLT A;  3RV0 A;  4F00 A;  2X5C A;  3D50 A;  3LLL A;  1LQ7 A;  3D51 A;  3KAV A;  2OW6 A;  2RAI A;  2Q13 A;  2F7Q A;  1TQU A;  3F7W A;  3EJR A;  3DPQ A;  2F1A A;  2OW7 A;  1R33 A;  4EZN A;  4FZP A;  4HY9 A;  1YWM A;  4R5I A;  3CKD A;  1DKX A;  4H6I A;  4EZX A;  2X3W A;  2WIN M;  1U00 A;  4G6Q A;  3QE6 A;  4AZC A;  2RAJ A;  3BVT A;  3QA8 A;  2KHO A;  4EZT A;  1OA1 A;  1X04 A;  2OBL A;  2Z0N A;  3HAI A;  3T4A G;  4H6H A;  2YLA A;  3DPP A;  4JWC A;  2QXL A;  3DX4 A;  1GN9 A;  3DDG A;  2F7O A;  3M3W A;  4R5L A;  3CAZ A;  4DYL A;  2LXY A;  4HR1 A;  2EFL A;  3EJU A;  2Z0V A;  1HWW A;  4FZS A;  5FIG A;  3G9G A;  4IM2 A;  1E2U A;  2Z8Y A;  3C7N A;  2YL9 A;  3QNJ A;  3HAJ A;  3T49 A;  4R5K A;  2OBM A;  4ATM A;  3RPM A;  3L3O M;  3BUI A;  1GNT A;  3UIT A;  3VEB A;  2MI7 A;  4AZI A;  4AZ6 A;  3QNI A;  4KIK A;  3ZED A;  4EZR A;  4UDY X;  4IWP A;  1DKY A;  4EZS A;  1X03 A;  2X3X A;  2V0O A;  2NCZ A;  1E9V A;  1QWU A;  1SU8 A;  2YIV X;  1TQS A;  1OAO A;  4IWO A;  1SU7 A;  4B9Q A;  3HAH A;  4E3C A;  3BUQ A; 
#chains in the Genus database with same CATH homology
 3G9G A;  3HAI A;  4NSW A;  5C5B A;  4DCN C;  2ELB A;  2X3W A;  2Z0O A;  3PLT A;  4AKV A;  1Y2O A;  4BNE A;  3HAH A;  3LLL A;  1I4L A;  2RAI A;  1WDZ A;  3Q84 A;  2D1L A;  2Q13 A;  3I2W A;  3QNI A;  2D4C A;  3QE6 A;  1ZWW A;  3ABH A;  3ACO A;  3OK8 A;  1I4T A;  2FIC A;  2X3V A;  3M3W A;  2RAJ A;  3DYT A;  3QWE A;  4NQI A;  3SYV A;  4WPE A;  1URU A;  3CAZ A;  4DYL A;  3SOG A;  4WPC A;  4AVM A;  1X03 A;  1I49 A;  1I4D A;  2X3X A;  3Q0K A;  2EFL A;  4I1Q A;  4H8S A;  2Z0V A;  2Q12 A;  2V0O A;  3HAJ A;  4FZS A;  2EFK A;  4ATM A;  5C5B B;  1X04 A;  2C08 A;  2Z0N A;  2YKT A;  2RAK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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