1I4DA

Crystal structure analysis of rac1-gdp complexed with arfaptin (p21)
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
200
structure length
188
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 88
structure length 188
sequence length 200
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4dA00
2FICA 1Y2OA 3HAIA 2D1LA 2EFLA 3QWEA 2EFKA 2RAJA 3PLTA 4NQIA 4NSWA 4WPEA 3SOGA 5C5BA 1I4LA 3Q84A 3HAHA 2C08A 3I2WA 2Q13A 3M3WA 3LLLA 2X3WA 3Q0KA 2RAKA 3SYVA 4WPCA 3DYTA 3ACOA 1X04A 4FZSA 3CAZA 3QNIA 2X3XA 4AKVA 3QE6A 2D4CA 1I4DA 5C5BB 2Z0OA 1I49A 3G9GA 3HAJA 3OK8A 1WDZA 2YKTA 2Z0NA 4DCNC 1URUA 2Z0VA 4I1QA 1ZWWA 1I4TA 2RAIA 4AVMA 2ELBA 4DYLA 4BNEA 2Q12A 4ATMA 2V0OA 3ABHA 1X03A 2X3VA 4H8SA
chains in the Genus database with same CATH superfamily
4AZCB 2RAJA 4EZTA 3BVXA 3CAZA 3CZSA 3OHXM 3T47A 3DPQA 3RV1A 4EZXA 1OA1A 2OZNB 1U00A 4B9QA 1QWUA 2F1BA 3BUDA 1LQ7A 3GI7A 3CV5A 2O0I1 4R5JA 2OBMA 3L3PA 4HY9A 4KIKB 2OW6A 1W9MA 2F7OA 3CZNA 4EZSA 4PO2A 3FD9A 3BUQA 4EZNA 2V0OA 3ABHA 4JLCA 2LM0A 4H6IA 3D2EA 5TKYA 3VEBA 3O3OB 1R33A 3LLLA 4EZOA 2PY6A 3ZEDA 2F7PA 1I49A 2YL6A 4DCNC 3CKDA 3DDGA 4JWIA 3EJUA 2D1LA 4AZBA 3RV0A 3DX1A 2WYIA 1E9VA 3BVUA 3EJPA 4WPCA 4AKVA 3ER9B 2YLLA 2Q12A 3M3WA 3OWGA 3T4AG 3CVRA 1YWMA 3KAWA 3ERCC 2X5CA 3DPOA 3F7WA 1O7DB 2YKTA 1SU8A 4M0MA 3BVWA 3D51A 2F18A 4JNEA 1R5EA 3D4YA 1SU6A 4NSWA 1I4LA 3DX2A 2X3WA 1E2UA 3A98A 2N3KA 3G9GA 3LVTA 4H6HA 1ZWWA 2YL8A 2FYVA 4EZWA 2KHOA 2OW7A 1ZYLA 2EFLA 4F00A 4G6QA 2ALWA 3QNJA 1TQSA 3BUPA 4F01A 3C7NA 3BUBA 4AZGA 2F7QA 2PMRA 1UPXA 3I01A 3I39X 4DYLA 3O3NB 2MI7A 4AZIA 1R34A 2EWFA 2FICA 1HTYA 3HAIA 1OAOA 1PS3A 2ND1A 1DKZA 2QKWA 4IWPA 4AZHA 4HR1B 2F1AA 4HYBA 4FZSA 4AZCA 2X3XA 2LXYA 4R5LA 2YI9A 4EZRA 1E1DA 1GNTA 2YIBA 5C5BB 3KDRA 4R5KA 5FLEX 2Z0NA 3BVTA 2F7RA 2OBLA 4UDXX 3KAVA 1QX1A 2EFKA 4IWOA 5FIGA 4IW0A 2ND0A 3HAJA 4EZQA 4KIKA 3EJRA 2QFFA 3LMFA 2Z8YA 3EJTA 3QE6A 2GAFD 2X3VA 2GF4A 2GA9D 3PLTA 3I04A 3ER8C 2RT6A 2YL9A 2WYHA 3Q0KA 1OA0A 3DYTA 3ACOA 4JWDA 2EX3B 1I4DA 2YIAA 4EZUA 4JWCA 1WDZA 5E84A 1GN9A 3DPPA 4IM2A 4FM3A 3RPMA 4WPEA 2JNKA 2ZXQA 1HXKA 4IM3A 3HAHA 3DX3A 3BVVA 3DX4A 2RAKA 2NCZA 1TQTA 3T49A 1TQUA 3VEAA 1URUA 2OO2A 4AVMA 4BNEA 4EZPA 4ATMA 1X03A 4D8JA 3DX0A 1Y2OA 1GNLA 3DDFA 3T46A 1DKXA 3D4ZA 3L3OM 2YIVX 3QNIA 2QXLA 2RAIA 3D52A 4H8SA 4EZVA 4NPHA 1HWWA 4E81A 3SOGA 4AZ5A 3I2WA 3VKHA 3O3MB 2D4CA 2Z0OA 4R5GA 1O7DC 4FZPA 1JQKA 1TQVA 4JWEA 4JN4A 3BUIA 3BLBA 3T48A 3EJQA 1X04A 4JNFA 3B53X 1QWNA 3OK8A 1DKYA 1SU7A 2YL5A 4UDYX 4E3CA 3D2FA 3UITA 3QWEA 4FZOA 4JL9A 2JNSA 2C08A 3SYVA 1MJGA 3B52X 2YLAA 3EJSA 4HR1A 2Z0VA 4AZ7A 2ELBA 4EZZA 5C5BA 1SUFA 5KBPA 4NQIA 4AZ6A 4IWQA 3Q84A 2YI8A 2Q13A 4IM0A 3B51X 3D50A 2WINM 1TQWA 4R5IA 4I1QA 1I4TA 4EZYA 3QA8A
chains in the Genus database with same CATH topology
2FICA 1Y2OA 3HAIA 2D1LA 2EFLA 3QWEA 2EFKA 2RAJA 3PLTA 4NQIA 4NSWA 4WPEA 3SOGA 5C5BA 1I4LA 3Q84A 3HAHA 2C08A 3I2WA 2Q13A 3M3WA 3LLLA 2X3WA 3Q0KA 2RAKA 3SYVA 4WPCA 3DYTA 3ACOA 1X04A 4FZSA 3CAZA 3QNIA 2X3XA 4AKVA 3QE6A 2D4CA 1I4DA 5C5BB 2Z0OA 1I49A 3G9GA 3HAJA 3OK8A 1WDZA 2YKTA 2Z0NA 4DCNC 1URUA 2Z0VA 4I1QA 1ZWWA 1I4TA 2RAIA 4AVMA 2ELBA 4DYLA 4BNEA 2Q12A 4ATMA 2V0OA 3ABHA 1X03A 2X3VA 4H8SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FIC A;  1Y2O A;  3HAI A;  2D1L A;  2EFL A;  3QWE A;  2EFK A;  2RAJ A;  3PLT A;  4NQI A;  4NSW A;  4WPE A;  3SOG A;  5C5B A;  1I4L A;  3Q84 A;  3HAH A;  2C08 A;  3I2W A;  2Q13 A;  3M3W A;  3LLL A;  2X3W A;  3Q0K A;  2RAK A;  3SYV A;  4WPC A;  3DYT A;  3ACO A;  1X04 A;  4FZS A;  3CAZ A;  3QNI A;  2X3X A;  4AKV A;  3QE6 A;  2D4C A;  1I4D A;  5C5B B;  2Z0O A;  1I49 A;  3G9G A;  3HAJ A;  3OK8 A;  1WDZ A;  2YKT A;  2Z0N A;  4DCN C;  1URU A;  2Z0V A;  4I1Q A;  1ZWW A;  1I4T A;  2RAI A;  4AVM A;  2ELB A;  4DYL A;  4BNE A;  2Q12 A;  4ATM A;  2V0O A;  3ABH A;  1X03 A;  2X3V A;  4H8S A; 
#chains in the Genus database with same CATH topology
 4AZC B;  2RAJ A;  4EZT A;  3BVX A;  3CAZ A;  3CZS A;  3OHX M;  3T47 A;  3DPQ A;  3RV1 A;  4EZX A;  1OA1 A;  2OZN B;  1U00 A;  4B9Q A;  1QWU A;  2F1B A;  3BUD A;  1LQ7 A;  3GI7 A;  3CV5 A;  2O0I 1;  4R5J A;  2OBM A;  3L3P A;  4HY9 A;  4KIK B;  2OW6 A;  1W9M A;  2F7O A;  3CZN A;  4EZS A;  4PO2 A;  3FD9 A;  3BUQ A;  4EZN A;  2V0O A;  3ABH A;  4JLC A;  2LM0 A;  4H6I A;  3D2E A;  5TKY A;  3VEB A;  3O3O B;  1R33 A;  3LLL A;  4EZO A;  2PY6 A;  3ZED A;  2F7P A;  1I49 A;  2YL6 A;  4DCN C;  3CKD A;  3DDG A;  4JWI A;  3EJU A;  2D1L A;  4AZB A;  3RV0 A;  3DX1 A;  2WYI A;  1E9V A;  3BVU A;  3EJP A;  4WPC A;  4AKV A;  3ER9 B;  2YLL A;  2Q12 A;  3M3W A;  3OWG A;  3T4A G;  3CVR A;  1YWM A;  3KAW A;  3ERC C;  2X5C A;  3DPO A;  3F7W A;  1O7D B;  2YKT A;  1SU8 A;  4M0M A;  3BVW A;  3D51 A;  2F18 A;  4JNE A;  1R5E A;  3D4Y A;  1SU6 A;  4NSW A;  1I4L A;  3DX2 A;  2X3W A;  1E2U A;  3A98 A;  2N3K A;  3G9G A;  3LVT A;  4H6H A;  1ZWW A;  2YL8 A;  2FYV A;  4EZW A;  2KHO A;  2OW7 A;  1ZYL A;  2EFL A;  4F00 A;  4G6Q A;  2ALW A;  3QNJ A;  1TQS A;  3BUP A;  4F01 A;  3C7N A;  3BUB A;  4AZG A;  2F7Q A;  2PMR A;  1UPX A;  3I01 A;  3I39 X;  4DYL A;  3O3N B;  2MI7 A;  4AZI A;  1R34 A;  2EWF A;  2FIC A;  1HTY A;  3HAI A;  1OAO A;  1PS3 A;  2ND1 A;  1DKZ A;  2QKW A;  4IWP A;  4AZH A;  4HR1 B;  2F1A A;  4HYB A;  4FZS A;  4AZC A;  2X3X A;  2LXY A;  4R5L A;  2YI9 A;  4EZR A;  1E1D A;  1GNT A;  2YIB A;  5C5B B;  3KDR A;  4R5K A;  5FLE X;  2Z0N A;  3BVT A;  2F7R A;  2OBL A;  4UDX X;  3KAV A;  1QX1 A;  2EFK A;  4IWO A;  5FIG A;  4IW0 A;  2ND0 A;  3HAJ A;  4EZQ A;  4KIK A;  3EJR A;  2QFF A;  3LMF A;  2Z8Y A;  3EJT A;  3QE6 A;  2GAF D;  2X3V A;  2GF4 A;  2GA9 D;  3PLT A;  3I04 A;  3ER8 C;  2RT6 A;  2YL9 A;  2WYH A;  3Q0K A;  1OA0 A;  3DYT A;  3ACO A;  4JWD A;  2EX3 B;  1I4D A;  2YIA A;  4EZU A;  4JWC A;  1WDZ A;  5E84 A;  1GN9 A;  3DPP A;  4IM2 A;  4FM3 A;  3RPM A;  4WPE A;  2JNK A;  2ZXQ A;  1HXK A;  4IM3 A;  3HAH A;  3DX3 A;  3BVV A;  3DX4 A;  2RAK A;  2NCZ A;  1TQT A;  3T49 A;  1TQU A;  3VEA A;  1URU A;  2OO2 A;  4AVM A;  4BNE A;  4EZP A;  4ATM A;  1X03 A;  4D8J A;  3DX0 A;  1Y2O A;  1GNL A;  3DDF A;  3T46 A;  1DKX A;  3D4Z A;  3L3O M;  2YIV X;  3QNI A;  2QXL A;  2RAI A;  3D52 A;  4H8S A;  4EZV A;  4NPH A;  1HWW A;  4E81 A;  3SOG A;  4AZ5 A;  3I2W A;  3VKH A;  3O3M B;  2D4C A;  2Z0O A;  4R5G A;  1O7D C;  4FZP A;  1JQK A;  1TQV A;  4JWE A;  4JN4 A;  3BUI A;  3BLB A;  3T48 A;  3EJQ A;  1X04 A;  4JNF A;  3B53 X;  1QWN A;  3OK8 A;  1DKY A;  1SU7 A;  2YL5 A;  4UDY X;  4E3C A;  3D2F A;  3UIT A;  3QWE A;  4FZO A;  4JL9 A;  2JNS A;  2C08 A;  3SYV A;  1MJG A;  3B52 X;  2YLA A;  3EJS A;  4HR1 A;  2Z0V A;  4AZ7 A;  2ELB A;  4EZZ A;  5C5B A;  1SUF A;  5KBP A;  4NQI A;  4AZ6 A;  4IWQ A;  3Q84 A;  2YI8 A;  2Q13 A;  4IM0 A;  3B51 X;  3D50 A;  2WIN M;  1TQW A;  4R5I A;  4I1Q A;  1I4T A;  4EZY A;  3QA8 A; 
#chains in the Genus database with same CATH homology
 2FIC A;  1Y2O A;  3HAI A;  2D1L A;  2EFL A;  3QWE A;  2EFK A;  2RAJ A;  3PLT A;  4NQI A;  4NSW A;  4WPE A;  3SOG A;  5C5B A;  1I4L A;  3Q84 A;  3HAH A;  2C08 A;  3I2W A;  2Q13 A;  3M3W A;  3LLL A;  2X3W A;  3Q0K A;  2RAK A;  3SYV A;  4WPC A;  3DYT A;  3ACO A;  1X04 A;  4FZS A;  3CAZ A;  3QNI A;  2X3X A;  4AKV A;  3QE6 A;  2D4C A;  1I4D A;  5C5B B;  2Z0O A;  1I49 A;  3G9G A;  3HAJ A;  3OK8 A;  1WDZ A;  2YKT A;  2Z0N A;  4DCN C;  1URU A;  2Z0V A;  4I1Q A;  1ZWW A;  1I4T A;  2RAI A;  4AVM A;  2ELB A;  4DYL A;  4BNE A;  2Q12 A;  4ATM A;  2V0O A;  3ABH A;  1X03 A;  2X3V A;  4H8S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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