1I4TA

Crystal structure analysis of rac1-gmppnp in complex with arfaptin
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
195
structure length
180
Chain Sequence
SRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords ARFAPTIN 2
total genus 83
structure length 180
sequence length 195
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-02-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1i4tA00
4WPEA 2ELBA 3PLTA 2V0OA 3HAHA 3SYVA 2Q13A 2Z0VA 4ATMA 3M3WA 3I2WA 1X04A 2FICA 3HAIA 5C5BA 2X3XA 2D1LA 4WPCA 3SOGA 1URUA 2X3VA 2C08A 2Z0OA 3LLLA 1WDZA 3ABHA 2EFKA 3Q84A 1I49A 3QE6A 2RAIA 2D4CA 3QNIA 5C5BB 3OK8A 3Q0KA 4NQIA 1I4LA 3CAZA 3G9GA 4FZSA 4I1QA 3HAJA 4BNEA 1X03A 3DYTA 3QWEA 4NSWA 1ZWWA 4DYLA 3ACOA 1I4TA 2X3WA 2Q12A 4AVMA 2RAKA 2RAJA 4H8SA 4DCNC 4AKVA 2Z0NA 2EFLA 2YKTA 1Y2OA 1I4DA
chains in the Genus database with same CATH superfamily
4JL9A 1YWMA 3D50A 2LXYA 2EX3B 3ER8C 2YL8A 3RPMA 4M0MA 5FLEX 2JNKA 4EZTA 4FM3A 5C5BB 3OHXM 2WINM 4R5KA 1HWWA 1HXKA 3DX1A 4IW0A 4AZHA 5KBPA 4PO2A 3VEAA 2OZNB 2YL5A 3O3MB 4R5IA 4IM2A 4AZ6A 4UDXX 3BVXA 1DKXA 2ND1A 2QXLA 1DKZA 2F7OA 2ZXQA 3HAJA 4JN4A 3DDFA 4DCNC 2RAJA 1SU8A 1I4DA 3BUIA 1PS3A 4ATMA 1SUFA 2YI9A 1WDZA 3OK8A 4BNEA 2X3WA 4AVMA 4AZCB 3EJQA 2EWFA 2ND0A 3OWGA 3L3PA 3I2WA 2NCZA 2Z8YA 2JNSA 3HAIA 4JWCA 1TQWA 3LMFA 2EFKA 1TQUA 3O3NB 2ALWA 3Q0KA 4IM0A 1ZWWA 2YI8A 4JWIA 3FD9A 4H8SA 3KAWA 4AZ7A 3BVTA 4EZOA 1MJGA 4HR1B 4F00A 2YL9A 4EZPA 3DX2A 4FZPA 3QA8A 3CZNA 4AZBA 4EZSA 1JQKA 1I4TA 4AKVA 4UDYX 3EJSA 2OBLA 4AZ5A 2OBMA 4G6QA 4AZIA 3Q84A 1E1DA 2QKWA 1E2UA 1R34A 4EZRA 1I4LA 3DPQA 4R5JA 3EJUA 2LM0A 3CKDA 1GNLA 3BVUA 4EZUA 3KAVA 2D1LA 1URUA 2X3VA 3D4YA 3T49A 2C08A 4IWQA 3QE6A 3BVVA 2YL6A 3D2FA 1O7DC 2PY6A 3DX3A 4EZYA 3RV1A 3DDGA 2WYIA 3ER9B 1R33A 3CZSA 2YLAA 1R5EA 4KIKB 3BVWA 2X5CA 4WPCA 3BUDA 4NPHA 2OW6A 1X03A 4EZXA 2RAKA 4H6HA 3UITA 3T4AG 3CV5A 4B9QA 5C5BA 2OW7A 4EZWA 1OA1A 2GA9D 3I04A 3F7WA 2YIVX 5FIGA 3QWEA 3ACOA 3GI7A 4E3CA 4R5GA 2EFLA 4WPEA 2ELBA 3QNJA 4JLCA 3PLTA 1HTYA 1SU6A 3BUBA 1E9VA 1ZYLA 3ABHA 3LVTA 3ZEDA 3G9GA 2YIAA 4NSWA 3VKHA 3ERCC 3DPPA 4IM3A 2GF4A 4JNEA 2Q13A 3DPOA 2FICA 2FYVA 4R5LA 3LLLA 2Z0OA 1TQSA 2YLLA 4AZCA 1TQTA 4IWOA 3QNIA 4H6IA 4EZVA 3M3WA 1X04A 3C7NA 4AZGA 5E84A 2KHOA 2MI7A 4IWPA 2WYHA 2RAIA 3BLBA 1GN9A 3T46A 1TQVA 4JWDA 4EZNA 4HR1A 4EZQA 3RV0A 3B51X 3DX4A 3KDRA 1W9MA 1UPXA 3EJRA 3B52X 4E81A 2F7PA 2O0I1 4DYLA 2GAFD 3BUPA 2F7QA 3L3OM 2Z0NA 3BUQA 1QX1A 3HAHA 2RT6A 3D51A 3SOGA 4HY9A 3D52A 1OAOA 4NQIA 1OA0A 3EJTA 3T48A 3A98A 3CVRA 4D8JA 4JNFA 3I01A 3D2EA 3DX0A 2Z0VA 1QWUA 1I49A 2F18A 3D4ZA 3T47A 4F01A 3CAZA 4FZSA 4I1QA 3DYTA 4KIKA 2Q12A 1O7DB 3EJPA 4JWEA 2F7RA 1LQ7A 1QWNA 2V0OA 3SYVA 5TKYA 2X3XA 1GNTA 4EZZA 2D4CA 1DKYA 4FZOA 3B53X 3O3OB 2F1BA 2F1AA 1SU7A 2N3KA 2YIBA 2PMRA 3I39X 4HYBA 2YKTA 1Y2OA 2QFFA 2OO2A 3VEBA 1U00A
chains in the Genus database with same CATH topology
4WPEA 2ELBA 3PLTA 2V0OA 3HAHA 3SYVA 2Q13A 2Z0VA 4ATMA 3M3WA 3I2WA 1X04A 2FICA 3HAIA 5C5BA 2X3XA 2D1LA 4WPCA 3SOGA 1URUA 2X3VA 2C08A 2Z0OA 3LLLA 1WDZA 3ABHA 2EFKA 3Q84A 1I49A 3QE6A 2RAIA 2D4CA 3QNIA 5C5BB 3OK8A 3Q0KA 4NQIA 1I4LA 3CAZA 3G9GA 4FZSA 4I1QA 3HAJA 4BNEA 1X03A 3DYTA 3QWEA 4NSWA 1ZWWA 4DYLA 3ACOA 1I4TA 2X3WA 2Q12A 4AVMA 2RAKA 2RAJA 4H8SA 4DCNC 4AKVA 2Z0NA 2EFLA 2YKTA 1Y2OA 1I4DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WPE A;  2ELB A;  3PLT A;  2V0O A;  3HAH A;  3SYV A;  2Q13 A;  2Z0V A;  4ATM A;  3M3W A;  3I2W A;  1X04 A;  2FIC A;  3HAI A;  5C5B A;  2X3X A;  2D1L A;  4WPC A;  3SOG A;  1URU A;  2X3V A;  2C08 A;  2Z0O A;  3LLL A;  1WDZ A;  3ABH A;  2EFK A;  3Q84 A;  1I49 A;  3QE6 A;  2RAI A;  2D4C A;  3QNI A;  5C5B B;  3OK8 A;  3Q0K A;  4NQI A;  1I4L A;  3CAZ A;  3G9G A;  4FZS A;  4I1Q A;  3HAJ A;  4BNE A;  1X03 A;  3DYT A;  3QWE A;  4NSW A;  1ZWW A;  4DYL A;  3ACO A;  1I4T A;  2X3W A;  2Q12 A;  4AVM A;  2RAK A;  2RAJ A;  4H8S A;  4DCN C;  4AKV A;  2Z0N A;  2EFL A;  2YKT A;  1Y2O A;  1I4D A; 
#chains in the Genus database with same CATH topology
 4JL9 A;  1YWM A;  3D50 A;  2LXY A;  2EX3 B;  3ER8 C;  2YL8 A;  3RPM A;  4M0M A;  5FLE X;  2JNK A;  4EZT A;  4FM3 A;  5C5B B;  3OHX M;  2WIN M;  4R5K A;  1HWW A;  1HXK A;  3DX1 A;  4IW0 A;  4AZH A;  5KBP A;  4PO2 A;  3VEA A;  2OZN B;  2YL5 A;  3O3M B;  4R5I A;  4IM2 A;  4AZ6 A;  4UDX X;  3BVX A;  1DKX A;  2ND1 A;  2QXL A;  1DKZ A;  2F7O A;  2ZXQ A;  3HAJ A;  4JN4 A;  3DDF A;  4DCN C;  2RAJ A;  1SU8 A;  1I4D A;  3BUI A;  1PS3 A;  4ATM A;  1SUF A;  2YI9 A;  1WDZ A;  3OK8 A;  4BNE A;  2X3W A;  4AVM A;  4AZC B;  3EJQ A;  2EWF A;  2ND0 A;  3OWG A;  3L3P A;  3I2W A;  2NCZ A;  2Z8Y A;  2JNS A;  3HAI A;  4JWC A;  1TQW A;  3LMF A;  2EFK A;  1TQU A;  3O3N B;  2ALW A;  3Q0K A;  4IM0 A;  1ZWW A;  2YI8 A;  4JWI A;  3FD9 A;  4H8S A;  3KAW A;  4AZ7 A;  3BVT A;  4EZO A;  1MJG A;  4HR1 B;  4F00 A;  2YL9 A;  4EZP A;  3DX2 A;  4FZP A;  3QA8 A;  3CZN A;  4AZB A;  4EZS A;  1JQK A;  1I4T A;  4AKV A;  4UDY X;  3EJS A;  2OBL A;  4AZ5 A;  2OBM A;  4G6Q A;  4AZI A;  3Q84 A;  1E1D A;  2QKW A;  1E2U A;  1R34 A;  4EZR A;  1I4L A;  3DPQ A;  4R5J A;  3EJU A;  2LM0 A;  3CKD A;  1GNL A;  3BVU A;  4EZU A;  3KAV A;  2D1L A;  1URU A;  2X3V A;  3D4Y A;  3T49 A;  2C08 A;  4IWQ A;  3QE6 A;  3BVV A;  2YL6 A;  3D2F A;  1O7D C;  2PY6 A;  3DX3 A;  4EZY A;  3RV1 A;  3DDG A;  2WYI A;  3ER9 B;  1R33 A;  3CZS A;  2YLA A;  1R5E A;  4KIK B;  3BVW A;  2X5C A;  4WPC A;  3BUD A;  4NPH A;  2OW6 A;  1X03 A;  4EZX A;  2RAK A;  4H6H A;  3UIT A;  3T4A G;  3CV5 A;  4B9Q A;  5C5B A;  2OW7 A;  4EZW A;  1OA1 A;  2GA9 D;  3I04 A;  3F7W A;  2YIV X;  5FIG A;  3QWE A;  3ACO A;  3GI7 A;  4E3C A;  4R5G A;  2EFL A;  4WPE A;  2ELB A;  3QNJ A;  4JLC A;  3PLT A;  1HTY A;  1SU6 A;  3BUB A;  1E9V A;  1ZYL A;  3ABH A;  3LVT A;  3ZED A;  3G9G A;  2YIA A;  4NSW A;  3VKH A;  3ERC C;  3DPP A;  4IM3 A;  2GF4 A;  4JNE A;  2Q13 A;  3DPO A;  2FIC A;  2FYV A;  4R5L A;  3LLL A;  2Z0O A;  1TQS A;  2YLL A;  4AZC A;  1TQT A;  4IWO A;  3QNI A;  4H6I A;  4EZV A;  3M3W A;  1X04 A;  3C7N A;  4AZG A;  5E84 A;  2KHO A;  2MI7 A;  4IWP A;  2WYH A;  2RAI A;  3BLB A;  1GN9 A;  3T46 A;  1TQV A;  4JWD A;  4EZN A;  4HR1 A;  4EZQ A;  3RV0 A;  3B51 X;  3DX4 A;  3KDR A;  1W9M A;  1UPX A;  3EJR A;  3B52 X;  4E81 A;  2F7P A;  2O0I 1;  4DYL A;  2GAF D;  3BUP A;  2F7Q A;  3L3O M;  2Z0N A;  3BUQ A;  1QX1 A;  3HAH A;  2RT6 A;  3D51 A;  3SOG A;  4HY9 A;  3D52 A;  1OAO A;  4NQI A;  1OA0 A;  3EJT A;  3T48 A;  3A98 A;  3CVR A;  4D8J A;  4JNF A;  3I01 A;  3D2E A;  3DX0 A;  2Z0V A;  1QWU A;  1I49 A;  2F18 A;  3D4Z A;  3T47 A;  4F01 A;  3CAZ A;  4FZS A;  4I1Q A;  3DYT A;  4KIK A;  2Q12 A;  1O7D B;  3EJP A;  4JWE A;  2F7R A;  1LQ7 A;  1QWN A;  2V0O A;  3SYV A;  5TKY A;  2X3X A;  1GNT A;  4EZZ A;  2D4C A;  1DKY A;  4FZO A;  3B53 X;  3O3O B;  2F1B A;  2F1A A;  1SU7 A;  2N3K A;  2YIB A;  2PMR A;  3I39 X;  4HYB A;  2YKT A;  1Y2O A;  2QFF A;  2OO2 A;  3VEB A;  1U00 A; 
#chains in the Genus database with same CATH homology
 4WPE A;  2ELB A;  3PLT A;  2V0O A;  3HAH A;  3SYV A;  2Q13 A;  2Z0V A;  4ATM A;  3M3W A;  3I2W A;  1X04 A;  2FIC A;  3HAI A;  5C5B A;  2X3X A;  2D1L A;  4WPC A;  3SOG A;  1URU A;  2X3V A;  2C08 A;  2Z0O A;  3LLL A;  1WDZ A;  3ABH A;  2EFK A;  3Q84 A;  1I49 A;  3QE6 A;  2RAI A;  2D4C A;  3QNI A;  5C5B B;  3OK8 A;  3Q0K A;  4NQI A;  1I4L A;  3CAZ A;  3G9G A;  4FZS A;  4I1Q A;  3HAJ A;  4BNE A;  1X03 A;  3DYT A;  3QWE A;  4NSW A;  1ZWW A;  4DYL A;  3ACO A;  1I4T A;  2X3W A;  2Q12 A;  4AVM A;  2RAK A;  2RAJ A;  4H8S A;  4DCN C;  4AKV A;  2Z0N A;  2EFL A;  2YKT A;  1Y2O A;  1I4D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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