1X04A

Crystal structure of endophilin bar domain (mutant)
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
200
structure length
200
Chain Sequence
GTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLAHLSSLLQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords SH3-containing GRB2-like protein 2
total genus 80
structure length 200
sequence length 200
ec nomenclature ec 2.3.1.-:
pdb deposition date 2005-03-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03114 BAR BAR domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 1x04A00
2D1LA 2X3VA 4AKVA 3Q84A 4AVMA 3ACOA 3LLLA 2RAJA 2X3XA 4NQIA 5C5BA 4BNEA 3QE6A 2Q13A 2X3WA 1ZWWA 1I4LA 2RAKA 2Z0NA 3HAHA 2C08A 3HAJA 3Q0KA 4FZSA 3HAIA 4NSWA 3DYTA 4DCNC 2Z0VA 3I2WA 3G9GA 4ATMA 1X04A 1I49A 2V0OA 3ABHA 2D4CA 1WDZA 4H8SA 3OK8A 2Z0OA 2EFLA 3M3WA 3PLTA 2FICA 3QNIA 2EFKA 3QWEA 4WPCA 1URUA 1I4TA 2Q12A 3CAZA 1I4DA 2ELBA 1X03A 3SOGA 3SYVA 4DYLA 2YKTA 2RAIA 4I1QA 4WPEA 1Y2OA 5C5BB
chains in the Genus database with same CATH superfamily
2D1LA 3DX3A 3BVUA 2Q13A 4JL9A 3LMFA 2ND1A 3CVRA 3KAWA 3HAIA 1PS3A 4HR1A 3I2WA 4H8SA 4EZXA 4JWCA 4E81A 1O7DC 3QWEA 3O3OB 4JWEA 1I4DA 1U00A 4AVMA 1HTYA 2RT6A 4AZ5A 4AZ7A 2JNSA 4AZGA 2QXLA 4EZUA 4EZRA 4HR1B 3DPQA 4EZNA 4AZCB 1QWUA 5FLEX 2OW7A 4AZBA 3SYVA 1YWMA 3O3NB 1HXKA 3EJSA 3ER8C 3CZNA 2RAKA 4UDYX 4EZYA 4AZ6A 4IW0A 4FM3A 2OBLA 1DKYA 3ER9B 3ABHA 2YL5A 4NPHA 1W9MA 4JWDA 3C7NA 2N3KA 4AZIA 1LQ7A 1Y2OA 2X3VA 2KHOA 4EZZA 3B52X 3EJRA 2GF4A 1ZYLA 4B9QA 1O7DB 1WDZA 2ND0A 3B53X 3T47A 3D50A 4EZWA 2YIAA 4KIKB 1TQVA 3I39X 2OZNB 3RV1A 1SUFA 3ZEDA 3CZSA 3BUQA 2PMRA 4D8JA 3D52A 3A98A 1SU6A 2WYIA 1QWNA 4M0MA 4IWPA 4R5JA 4EZSA 3VEAA 3BLBA 2F7OA 2X3XA 1SU7A 2X3WA 4H6IA 5E84A 4H6HA 4F01A 4AZCA 4WPCA 1I4TA 3DDGA 3LVTA 3CV5A 3T4AG 3D51A 2YL9A 2YL8A 3F7WA 3Q84A 3EJTA 1GNTA 4HY9A 4FZPA 1ZWWA 2OW6A 1R33A 2C08A 3KDRA 2PY6A 2YI9A 2EWFA 2F7QA 1UPXA 2EFKA 3D4ZA 4JLCA 3DX4A 3FD9A 1GNLA 2Z8YA 4JNEA 3BUDA 3BVWA 3BUPA 1OA0A 2YI8A 1I4LA 4IM3A 4FZSA 3Q0KA 1E1DA 3DPPA 1DKXA 1URUA 2Q12A 3SOGA 2YLAA 3VEBA 3OWGA 1TQTA 4IWOA 3LLLA 4KIKA 2V0OA 2EX3B 1OA1A 2F7RA 1SU8A 3OK8A 4R5GA 3M3WA 3QNIA 2ELBA 2FYVA 2YIVX 3L3OM 3D4YA 1R34A 3B51X 2LXYA 2GA9D 2F7PA 2F1BA 2OO2A 5FIGA 3T49A 3L3PA 3DX0A 3ERCC 5TKYA 1TQUA 4UDXX 4I1QA 1MJGA 5C5BB 3BVXA 3O3MB 4R5IA 4NQIA 3BVVA 2NCZA 3QE6A 3T48A 4G6QA 2Z0NA 4NSWA 3EJUA 3EJPA 4JWIA 1I49A 2QKWA 1QX1A 3UITA 2GAFD 4IM0A 2F1AA 3BUBA 3DPOA 3ACOA 1GN9A 4AZHA 2F18A 2WINM 2ZXQA 3RV0A 5KBPA 3DYTA 2Z0VA 3G9GA 3DDFA 3BUIA 1HWWA 4EZPA 4EZOA 1JQKA 3VKHA 4EZVA 4AKVA 3QNJA 1E2UA 2RAJA 2OBMA 2LM0A 4BNEA 2ALWA 2YL6A 3DX2A 3D2FA 1X04A 3PLTA 4FZOA 2FICA 3EJQA 3GI7A 4DYLA 2RAIA 3OHXM 4WPEA 2QFFA 3BVTA 4R5KA 4PO2A 4F00A 3HAHA 4R5LA 4EZQA 4IWQA 2JNKA 1TQWA 4HYBA 1DKZA 1R5EA 2MI7A 3D2EA 4E3CA 2X5CA 5C5BA 1E9VA 1OAOA 3QA8A 1TQSA 2D4CA 3KAVA 2WYHA 4EZTA 2YKTA 4JN4A 2YLLA 3RPMA 2O0I1 3I04A 2YIBA 3T46A 3HAJA 4DCNC 4ATMA 3CKDA 2Z0OA 3DX1A 2EFLA 3I01A 4IM2A 3CAZA 1X03A 4JNFA
chains in the Genus database with same CATH topology
2D1LA 2X3VA 4AKVA 3Q84A 4AVMA 3ACOA 3LLLA 2RAJA 2X3XA 4NQIA 5C5BA 4BNEA 3QE6A 2Q13A 2X3WA 1ZWWA 1I4LA 2RAKA 2Z0NA 3HAHA 2C08A 3HAJA 3Q0KA 4FZSA 3HAIA 4NSWA 3DYTA 4DCNC 2Z0VA 3I2WA 3G9GA 4ATMA 1X04A 1I49A 2V0OA 3ABHA 2D4CA 1WDZA 4H8SA 3OK8A 2Z0OA 2EFLA 3M3WA 3PLTA 2FICA 3QNIA 2EFKA 3QWEA 4WPCA 1URUA 1I4TA 2Q12A 3CAZA 1I4DA 2ELBA 1X03A 3SOGA 3SYVA 4DYLA 2YKTA 2RAIA 4I1QA 4WPEA 1Y2OA 5C5BB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2D1L A;  2X3V A;  4AKV A;  3Q84 A;  4AVM A;  3ACO A;  3LLL A;  2RAJ A;  2X3X A;  4NQI A;  5C5B A;  4BNE A;  3QE6 A;  2Q13 A;  2X3W A;  1ZWW A;  1I4L A;  2RAK A;  2Z0N A;  3HAH A;  2C08 A;  3HAJ A;  3Q0K A;  4FZS A;  3HAI A;  4NSW A;  3DYT A;  4DCN C;  2Z0V A;  3I2W A;  3G9G A;  4ATM A;  1X04 A;  1I49 A;  2V0O A;  3ABH A;  2D4C A;  1WDZ A;  4H8S A;  3OK8 A;  2Z0O A;  2EFL A;  3M3W A;  3PLT A;  2FIC A;  3QNI A;  2EFK A;  3QWE A;  4WPC A;  1URU A;  1I4T A;  2Q12 A;  3CAZ A;  1I4D A;  2ELB A;  1X03 A;  3SOG A;  3SYV A;  4DYL A;  2YKT A;  2RAI A;  4I1Q A;  4WPE A;  1Y2O A;  5C5B B; 
#chains in the Genus database with same CATH topology
 2D1L A;  3DX3 A;  3BVU A;  2Q13 A;  4JL9 A;  3LMF A;  2ND1 A;  3CVR A;  3KAW A;  3HAI A;  1PS3 A;  4HR1 A;  3I2W A;  4H8S A;  4EZX A;  4JWC A;  4E81 A;  1O7D C;  3QWE A;  3O3O B;  4JWE A;  1I4D A;  1U00 A;  4AVM A;  1HTY A;  2RT6 A;  4AZ5 A;  4AZ7 A;  2JNS A;  4AZG A;  2QXL A;  4EZU A;  4EZR A;  4HR1 B;  3DPQ A;  4EZN A;  4AZC B;  1QWU A;  5FLE X;  2OW7 A;  4AZB A;  3SYV A;  1YWM A;  3O3N B;  1HXK A;  3EJS A;  3ER8 C;  3CZN A;  2RAK A;  4UDY X;  4EZY A;  4AZ6 A;  4IW0 A;  4FM3 A;  2OBL A;  1DKY A;  3ER9 B;  3ABH A;  2YL5 A;  4NPH A;  1W9M A;  4JWD A;  3C7N A;  2N3K A;  4AZI A;  1LQ7 A;  1Y2O A;  2X3V A;  2KHO A;  4EZZ A;  3B52 X;  3EJR A;  2GF4 A;  1ZYL A;  4B9Q A;  1O7D B;  1WDZ A;  2ND0 A;  3B53 X;  3T47 A;  3D50 A;  4EZW A;  2YIA A;  4KIK B;  1TQV A;  3I39 X;  2OZN B;  3RV1 A;  1SUF A;  3ZED A;  3CZS A;  3BUQ A;  2PMR A;  4D8J A;  3D52 A;  3A98 A;  1SU6 A;  2WYI A;  1QWN A;  4M0M A;  4IWP A;  4R5J A;  4EZS A;  3VEA A;  3BLB A;  2F7O A;  2X3X A;  1SU7 A;  2X3W A;  4H6I A;  5E84 A;  4H6H A;  4F01 A;  4AZC A;  4WPC A;  1I4T A;  3DDG A;  3LVT A;  3CV5 A;  3T4A G;  3D51 A;  2YL9 A;  2YL8 A;  3F7W A;  3Q84 A;  3EJT A;  1GNT A;  4HY9 A;  4FZP A;  1ZWW A;  2OW6 A;  1R33 A;  2C08 A;  3KDR A;  2PY6 A;  2YI9 A;  2EWF A;  2F7Q A;  1UPX A;  2EFK A;  3D4Z A;  4JLC A;  3DX4 A;  3FD9 A;  1GNL A;  2Z8Y A;  4JNE A;  3BUD A;  3BVW A;  3BUP A;  1OA0 A;  2YI8 A;  1I4L A;  4IM3 A;  4FZS A;  3Q0K A;  1E1D A;  3DPP A;  1DKX A;  1URU A;  2Q12 A;  3SOG A;  2YLA A;  3VEB A;  3OWG A;  1TQT A;  4IWO A;  3LLL A;  4KIK A;  2V0O A;  2EX3 B;  1OA1 A;  2F7R A;  1SU8 A;  3OK8 A;  4R5G A;  3M3W A;  3QNI A;  2ELB A;  2FYV A;  2YIV X;  3L3O M;  3D4Y A;  1R34 A;  3B51 X;  2LXY A;  2GA9 D;  2F7P A;  2F1B A;  2OO2 A;  5FIG A;  3T49 A;  3L3P A;  3DX0 A;  3ERC C;  5TKY A;  1TQU A;  4UDX X;  4I1Q A;  1MJG A;  5C5B B;  3BVX A;  3O3M B;  4R5I A;  4NQI A;  3BVV A;  2NCZ A;  3QE6 A;  3T48 A;  4G6Q A;  2Z0N A;  4NSW A;  3EJU A;  3EJP A;  4JWI A;  1I49 A;  2QKW A;  1QX1 A;  3UIT A;  2GAF D;  4IM0 A;  2F1A A;  3BUB A;  3DPO A;  3ACO A;  1GN9 A;  4AZH A;  2F18 A;  2WIN M;  2ZXQ A;  3RV0 A;  5KBP A;  3DYT A;  2Z0V A;  3G9G A;  3DDF A;  3BUI A;  1HWW A;  4EZP A;  4EZO A;  1JQK A;  3VKH A;  4EZV A;  4AKV A;  3QNJ A;  1E2U A;  2RAJ A;  2OBM A;  2LM0 A;  4BNE A;  2ALW A;  2YL6 A;  3DX2 A;  3D2F A;  1X04 A;  3PLT A;  4FZO A;  2FIC A;  3EJQ A;  3GI7 A;  4DYL A;  2RAI A;  3OHX M;  4WPE A;  2QFF A;  3BVT A;  4R5K A;  4PO2 A;  4F00 A;  3HAH A;  4R5L A;  4EZQ A;  4IWQ A;  2JNK A;  1TQW A;  4HYB A;  1DKZ A;  1R5E A;  2MI7 A;  3D2E A;  4E3C A;  2X5C A;  5C5B A;  1E9V A;  1OAO A;  3QA8 A;  1TQS A;  2D4C A;  3KAV A;  2WYH A;  4EZT A;  2YKT A;  4JN4 A;  2YLL A;  3RPM A;  2O0I 1;  3I04 A;  2YIB A;  3T46 A;  3HAJ A;  4DCN C;  4ATM A;  3CKD A;  2Z0O A;  3DX1 A;  2EFL A;  3I01 A;  4IM2 A;  3CAZ A;  1X03 A;  4JNF A; 
#chains in the Genus database with same CATH homology
 2D1L A;  2X3V A;  4AKV A;  3Q84 A;  4AVM A;  3ACO A;  3LLL A;  2RAJ A;  2X3X A;  4NQI A;  5C5B A;  4BNE A;  3QE6 A;  2Q13 A;  2X3W A;  1ZWW A;  1I4L A;  2RAK A;  2Z0N A;  3HAH A;  2C08 A;  3HAJ A;  3Q0K A;  4FZS A;  3HAI A;  4NSW A;  3DYT A;  4DCN C;  2Z0V A;  3I2W A;  3G9G A;  4ATM A;  1X04 A;  1I49 A;  2V0O A;  3ABH A;  2D4C A;  1WDZ A;  4H8S A;  3OK8 A;  2Z0O A;  2EFL A;  3M3W A;  3PLT A;  2FIC A;  3QNI A;  2EFK A;  3QWE A;  4WPC A;  1URU A;  1I4T A;  2Q12 A;  3CAZ A;  1I4D A;  2ELB A;  1X03 A;  3SOG A;  3SYV A;  4DYL A;  2YKT A;  2RAI A;  4I1Q A;  4WPE A;  1Y2O A;  5C5B B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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