2D1LA

Structure of f-actin binding domain imd of mim (missing in metastasis)
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
249
structure length
249
Chain Sequence
AGHMEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the actin-binding function of missing-in-metastasis
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords Metastasis suppressor protein 1
total genus 101
structure length 249
sequence length 249
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08397 IMD IRSp53/MIM homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2d1lA00
3SOGA 3QWEA 2X3VA 2C08A 3Q84A 1X04A 1X03A 2RAJA 2YKTA 3ABHA 1Y2OA 2Z0VA 2Q12A 4AKVA 3DYTA 2Q13A 3OK8A 3QNIA 2V0OA 2ELBA 3G9GA 3Q0KA 1WDZA 1URUA 5C5BB 1I4LA 2RAIA 2EFLA 3SYVA 5C5BA 2X3WA 4I1QA 2Z0OA 2X3XA 2Z0NA 3ACOA 3I2WA 3QE6A 2FICA 2EFKA 4H8SA 4WPCA 1I49A 4DYLA 3PLTA 3HAIA 4FZSA 2RAKA 4ATMA 1I4DA 3HAHA 3HAJA 4WPEA 4AVMA 4NQIA 4BNEA 4DCNC 3LLLA 3CAZA 4NSWA 2D4CA 1ZWWA 3M3WA 1I4TA 2D1LA
chains in the Genus database with same CATH superfamily
3BVUA 2YLLA 4UDXX 3BUIA 4AZ6A 1MJGA 5FLEX 3OHXM 5KBPA 1JQKA 4IWPA 3A98A 3DPPA 4H8SA 3D50A 4KIKA 4HR1A 3LVTA 2PMRA 1QWNA 2F1AA 1TQVA 2OBLA 2ND0A 1URUA 1TQWA 3DX2A 3OWGA 4KIKB 3ERCC 2KHOA 2LM0A 3EJUA 3DPOA 1GNLA 3T48A 4R5LA 4EZRA 2YI9A 3T49A 3EJSA 3C7NA 2Z0OA 1OAOA 3HAIA 4FZSA 3GI7A 3LLLA 4NSWA 3D4ZA 2D1LA 3BUQA 4JNFA 2YI8A 1SU6A 1X04A 3BUBA 2X5CA 4AZHA 1TQTA 4IM2A 1HWWA 3B53X 1DKYA 3VEAA 2EFLA 3SYVA 1OA1A 4F00A 5E84A 1ZWWA 4EZYA 1GNTA 3Q84A 2RAJA 4JWCA 1Y2OA 2EWFA 4UDYX 3ER8C 2RAIA 2X3XA 4JN4A 5FIGA 3DX1A 2YL5A 3KAWA 1R34A 3CKDA 1DKXA 2D4CA 4JWEA 1GN9A 2QXLA 4IW0A 4IM3A 2GA9D 1ZYLA 3RPMA 4AKVA 3CZSA 3BVWA 5C5BA 2RT6A 4WPCA 3PLTA 2RAKA 3B52X 2WINM 4DCNC 3L3OM 3M3WA 2ZXQA 2OBMA 2MI7A 4M0MA 2V0OA 3RV0A 5C5BB 3EJTA 2ND1A 2F1BA 3QE6A 2WYHA 4AZIA 1I4DA 3HAHA 3BUDA 3DX3A 3D2FA 4JNEA 2GF4A 4EZUA 4EZZA 4EZQA 3VEBA 4JL9A 1I4LA 3ZEDA 1QX1A 2F7OA 3F7WA 2QKWA 3EJPA 2Z8YA 2WYIA 4E3CA 3QWEA 2OO2A 4AZBA 4FZPA 3QNJA 2QFFA 3DPQA 3D52A 1W9MA 3T47A 4JWDA 1U00A 1LQ7A 3FD9A 1TQSA 4R5KA 1E9VA 1O7DC 1DKZA 3O3OB 1R5EA 3ABHA 1OA0A 3EJRA 3Q0KA 2EX3B 2F18A 4IWQA 3HAJA 5TKYA 2NCZA 1HTYA 3SOGA 3ER9B 2X3VA 2C08A 1SU8A 3KAVA 4JWIA 2Z0VA 4R5GA 1PS3A 2YL8A 1QWUA 3OK8A 4H6IA 2ELBA 3D51A 2FYVA 1E2UA 4EZSA 2YIAA 4BNEA 2JNKA 4FZOA 2YL9A 2YKTA 3D2EA 3KDRA 2F7QA 1WDZA 2GAFD 4IWOA 1UPXA 2OW6A 3BVVA 3I39X 2OW7A 1SU7A 4DYLA 4AVMA 3CVRA 3CAZA 4FM3A 3O3NB 4R5IA 2F7PA 3DDFA 4EZTA 3T46A 3BUPA 3D4YA 4AZGA 1YWMA 4E81A 4I1QA 2Z0NA 3I2WA 3ACOA 4HR1B 3I01A 2EFKA 1I49A 1TQUA 3LMFA 4WPEA 3BVXA 3CV5A 4AZCA 4HY9A 4AZ5A 4EZXA 4EZWA 1SUFA 1X03A 3UITA 4HYBA 3DYTA 3QA8A 1O7DB 3B51X 2X3WA 1HXKA 3L3PA 4D8JA 3RV1A 4AZCB 3T4AG 1E1DA 3VKHA 2ALWA 1I4TA 3G9GA 4R5JA 2N3KA 4AZ7A 2YLAA 1R33A 4EZPA 3CZNA 3DDGA 2Q13A 2LXYA 2O0I1 4EZOA 4PO2A 3BVTA 2PY6A 4H6HA 3BLBA 2YIBA 2YIVX 2JNSA 2YL6A 4NQIA 3DX0A 2F7RA 3I04A 4NPHA 2Q12A 4IM0A 3QNIA 4EZVA 4EZNA 4JLCA 3DX4A 4B9QA 2OZNB 4F01A 2FICA 3O3MB 3EJQA 4G6QA 4ATMA
chains in the Genus database with same CATH topology
3SOGA 3QWEA 2X3VA 2C08A 3Q84A 1X04A 1X03A 2RAJA 2YKTA 3ABHA 1Y2OA 2Z0VA 2Q12A 4AKVA 3DYTA 2Q13A 3OK8A 3QNIA 2V0OA 2ELBA 3G9GA 3Q0KA 1WDZA 1URUA 5C5BB 1I4LA 2RAIA 2EFLA 3SYVA 5C5BA 2X3WA 4I1QA 2Z0OA 2X3XA 2Z0NA 3ACOA 3I2WA 3QE6A 2FICA 2EFKA 4H8SA 4WPCA 1I49A 4DYLA 3PLTA 3HAIA 4FZSA 2RAKA 4ATMA 1I4DA 3HAHA 3HAJA 4WPEA 4AVMA 4NQIA 4BNEA 4DCNC 3LLLA 3CAZA 4NSWA 2D4CA 1ZWWA 3M3WA 1I4TA 2D1LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SOG A;  3QWE A;  2X3V A;  2C08 A;  3Q84 A;  1X04 A;  1X03 A;  2RAJ A;  2YKT A;  3ABH A;  1Y2O A;  2Z0V A;  2Q12 A;  4AKV A;  3DYT A;  2Q13 A;  3OK8 A;  3QNI A;  2V0O A;  2ELB A;  3G9G A;  3Q0K A;  1WDZ A;  1URU A;  5C5B B;  1I4L A;  2RAI A;  2EFL A;  3SYV A;  5C5B A;  2X3W A;  4I1Q A;  2Z0O A;  2X3X A;  2Z0N A;  3ACO A;  3I2W A;  3QE6 A;  2FIC A;  2EFK A;  4H8S A;  4WPC A;  1I49 A;  4DYL A;  3PLT A;  3HAI A;  4FZS A;  2RAK A;  4ATM A;  1I4D A;  3HAH A;  3HAJ A;  4WPE A;  4AVM A;  4NQI A;  4BNE A;  4DCN C;  3LLL A;  3CAZ A;  4NSW A;  2D4C A;  1ZWW A;  3M3W A;  1I4T A;  2D1L A; 
#chains in the Genus database with same CATH topology
 3BVU A;  2YLL A;  4UDX X;  3BUI A;  4AZ6 A;  1MJG A;  5FLE X;  3OHX M;  5KBP A;  1JQK A;  4IWP A;  3A98 A;  3DPP A;  4H8S A;  3D50 A;  4KIK A;  4HR1 A;  3LVT A;  2PMR A;  1QWN A;  2F1A A;  1TQV A;  2OBL A;  2ND0 A;  1URU A;  1TQW A;  3DX2 A;  3OWG A;  4KIK B;  3ERC C;  2KHO A;  2LM0 A;  3EJU A;  3DPO A;  1GNL A;  3T48 A;  4R5L A;  4EZR A;  2YI9 A;  3T49 A;  3EJS A;  3C7N A;  2Z0O A;  1OAO A;  3HAI A;  4FZS A;  3GI7 A;  3LLL A;  4NSW A;  3D4Z A;  2D1L A;  3BUQ A;  4JNF A;  2YI8 A;  1SU6 A;  1X04 A;  3BUB A;  2X5C A;  4AZH A;  1TQT A;  4IM2 A;  1HWW A;  3B53 X;  1DKY A;  3VEA A;  2EFL A;  3SYV A;  1OA1 A;  4F00 A;  5E84 A;  1ZWW A;  4EZY A;  1GNT A;  3Q84 A;  2RAJ A;  4JWC A;  1Y2O A;  2EWF A;  4UDY X;  3ER8 C;  2RAI A;  2X3X A;  4JN4 A;  5FIG A;  3DX1 A;  2YL5 A;  3KAW A;  1R34 A;  3CKD A;  1DKX A;  2D4C A;  4JWE A;  1GN9 A;  2QXL A;  4IW0 A;  4IM3 A;  2GA9 D;  1ZYL A;  3RPM A;  4AKV A;  3CZS A;  3BVW A;  5C5B A;  2RT6 A;  4WPC A;  3PLT A;  2RAK A;  3B52 X;  2WIN M;  4DCN C;  3L3O M;  3M3W A;  2ZXQ A;  2OBM A;  2MI7 A;  4M0M A;  2V0O A;  3RV0 A;  5C5B B;  3EJT A;  2ND1 A;  2F1B A;  3QE6 A;  2WYH A;  4AZI A;  1I4D A;  3HAH A;  3BUD A;  3DX3 A;  3D2F A;  4JNE A;  2GF4 A;  4EZU A;  4EZZ A;  4EZQ A;  3VEB A;  4JL9 A;  1I4L A;  3ZED A;  1QX1 A;  2F7O A;  3F7W A;  2QKW A;  3EJP A;  2Z8Y A;  2WYI A;  4E3C A;  3QWE A;  2OO2 A;  4AZB A;  4FZP A;  3QNJ A;  2QFF A;  3DPQ A;  3D52 A;  1W9M A;  3T47 A;  4JWD A;  1U00 A;  1LQ7 A;  3FD9 A;  1TQS A;  4R5K A;  1E9V A;  1O7D C;  1DKZ A;  3O3O B;  1R5E A;  3ABH A;  1OA0 A;  3EJR A;  3Q0K A;  2EX3 B;  2F18 A;  4IWQ A;  3HAJ A;  5TKY A;  2NCZ A;  1HTY A;  3SOG A;  3ER9 B;  2X3V A;  2C08 A;  1SU8 A;  3KAV A;  4JWI A;  2Z0V A;  4R5G A;  1PS3 A;  2YL8 A;  1QWU A;  3OK8 A;  4H6I A;  2ELB A;  3D51 A;  2FYV A;  1E2U A;  4EZS A;  2YIA A;  4BNE A;  2JNK A;  4FZO A;  2YL9 A;  2YKT A;  3D2E A;  3KDR A;  2F7Q A;  1WDZ A;  2GAF D;  4IWO A;  1UPX A;  2OW6 A;  3BVV A;  3I39 X;  2OW7 A;  1SU7 A;  4DYL A;  4AVM A;  3CVR A;  3CAZ A;  4FM3 A;  3O3N B;  4R5I A;  2F7P A;  3DDF A;  4EZT A;  3T46 A;  3BUP A;  3D4Y A;  4AZG A;  1YWM A;  4E81 A;  4I1Q A;  2Z0N A;  3I2W A;  3ACO A;  4HR1 B;  3I01 A;  2EFK A;  1I49 A;  1TQU A;  3LMF A;  4WPE A;  3BVX A;  3CV5 A;  4AZC A;  4HY9 A;  4AZ5 A;  4EZX A;  4EZW A;  1SUF A;  1X03 A;  3UIT A;  4HYB A;  3DYT A;  3QA8 A;  1O7D B;  3B51 X;  2X3W A;  1HXK A;  3L3P A;  4D8J A;  3RV1 A;  4AZC B;  3T4A G;  1E1D A;  3VKH A;  2ALW A;  1I4T A;  3G9G A;  4R5J A;  2N3K A;  4AZ7 A;  2YLA A;  1R33 A;  4EZP A;  3CZN A;  3DDG A;  2Q13 A;  2LXY A;  2O0I 1;  4EZO A;  4PO2 A;  3BVT A;  2PY6 A;  4H6H A;  3BLB A;  2YIB A;  2YIV X;  2JNS A;  2YL6 A;  4NQI A;  3DX0 A;  2F7R A;  3I04 A;  4NPH A;  2Q12 A;  4IM0 A;  3QNI A;  4EZV A;  4EZN A;  4JLC A;  3DX4 A;  4B9Q A;  2OZN B;  4F01 A;  2FIC A;  3O3M B;  3EJQ A;  4G6Q A;  4ATM A; 
#chains in the Genus database with same CATH homology
 3SOG A;  3QWE A;  2X3V A;  2C08 A;  3Q84 A;  1X04 A;  1X03 A;  2RAJ A;  2YKT A;  3ABH A;  1Y2O A;  2Z0V A;  2Q12 A;  4AKV A;  3DYT A;  2Q13 A;  3OK8 A;  3QNI A;  2V0O A;  2ELB A;  3G9G A;  3Q0K A;  1WDZ A;  1URU A;  5C5B B;  1I4L A;  2RAI A;  2EFL A;  3SYV A;  5C5B A;  2X3W A;  4I1Q A;  2Z0O A;  2X3X A;  2Z0N A;  3ACO A;  3I2W A;  3QE6 A;  2FIC A;  2EFK A;  4H8S A;  4WPC A;  1I49 A;  4DYL A;  3PLT A;  3HAI A;  4FZS A;  2RAK A;  4ATM A;  1I4D A;  3HAH A;  3HAJ A;  4WPE A;  4AVM A;  4NQI A;  4BNE A;  4DCN C;  3LLL A;  3CAZ A;  4NSW A;  2D4C A;  1ZWW A;  3M3W A;  1I4T A;  2D1L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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