2EFKA

Crystal structure of the efc domain of cdc42-interacting protein 4
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
280
structure length
273
Chain Sequence
GQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
pubmed doi rcsb
molecule tags Endocytosis/exocytosis
source organism Homo sapiens
molecule keywords Cdc42-interacting protein 4
total genus 118
structure length 273
sequence length 280
ec nomenclature
pdb deposition date 2007-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00611 FCH Fes/CIP4, and EFC/F-BAR homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2efkA01
2X3XA 2EFKA 2Z0OA 3HAIA 2RAIA 3QWEA 4WPEA 3G9GA 3ACOA 3HAJA 3SYVA 1X03A 2Q12A 2X3WA 3LLLA 3Q84A 1WDZA 1X04A 1I4LA 2EFLA 2V0OA 3CAZA 1URUA 4BNEA 2RAJA 4H8SA 5C5BA 2Z0NA 2C08A 1I4DA 3I2WA 3DYTA 1I4TA 3ABHA 4DCNC 3Q0KA 2YKTA 2X3VA 3HAHA 3PLTA 2D1LA 1I49A 2Z0VA 4ATMA 2ELBA 3M3WA 4DYLA 1ZWWA 4FZSA 2D4CA 1Y2OA 3SOGA 4NQIA 4NSWA 4AKVA 2Q13A 2RAKA 3QNIA 4I1QA 3QE6A 4AVMA 2FICA 4WPCA 5C5BB 3OK8A
chains in the Genus database with same CATH superfamily
2GAFD 4HR1B 5FLEX 2Q12A 4AZIA 3I04A 4BNEA 2EX3B 3Q0KA 4ATMA 2ELBA 3B51X 3EJRA 2PMRA 4G6QA 4WPCA 2F18A 4F01A 4JWEA 1MJGA 3O3OB 3ER9B 4HY9A 4JWIA 4AZGA 4JLCA 1JQKA 4DYLA 4R5IA 1TQVA 1YWMA 3SOGA 1QWUA 3BVTA 3T46A 3BUPA 3RPMA 4I1QA 2LM0A 3CZSA 3DPOA 2X5CA 5TKYA 2EWFA 4AZCA 2MI7A 4JN4A 1I4LA 2ALWA 2F1AA 1OA0A 3KAVA 1O7DB 4FM3A 4DCNC 4IWPA 3BUQA 4UDYX 4AZBA 4IWQA 4EZZA 3D51A 2RAIA 1U00A 4E81A 3ERCC 3G9GA 3UITA 1HTYA 4KIKB 4H8SA 3DX0A 3BVXA 1TQUA 2GA9D 2OZNB 4IW0A 2O0I1 4JWDA 2YIVX 4FZSA 3D4ZA 3CV5A 1QX1A 3DPQA 2F7QA 3KAWA 3O3NB 3ACOA 3I01A 3DPPA 3EJQA 2X3WA 5E84A 2FYVA 1R5EA 1UPXA 2V0OA 3RV0A 3DDFA 1SU8A 2X3VA 1SU6A 2YIBA 3T49A 3DX1A 2N3KA 1URUA 2RAJA 2JNKA 2Z0NA 4UDXX 3PLTA 4AZCB 2YL6A 3BVWA 3HAIA 2OBMA 4FZPA 2WYHA 3BUDA 3SYVA 1X03A 2QFFA 4JWCA 3DX3A 3ER8C 4H6IA 1TQSA 2C08A 2OW7A 3ABHA 2YLLA 4B9QA 4IM2A 3VEAA 3L3OM 3EJPA 1R33A 4EZPA 4EZXA 3CZNA 1QWNA 4AZ6A 3D4YA 4H6HA 3D2EA 2D4CA 4E3CA 3C7NA 5C5BB 2X3XA 3FD9A 3B52X 1O7DC 2NCZA 2LXYA 3BUBA 3DYTA 1W9MA 1OAOA 1I49A 2D1LA 3I39X 4AZHA 4PO2A 2Q13A 2RAKA 4M0MA 3D50A 3BLBA 1TQWA 2QKWA 3B53X 2JNSA 3BVUA 3KDRA 2YKTA 2QXLA 4EZWA 1ZWWA 4F00A 1Y2OA 4NQIA 4NSWA 4HYBA 2OO2A 4JNFA 3BUIA 4WPEA 1E1DA 3Q84A 4EZSA 1SUFA 3OHXM 3BVVA 3DX2A 3DDGA 4EZOA 2YL8A 4AKVA 3L3PA 4EZYA 3VKHA 3OK8A 3RV1A 3VEBA 1GNTA 4EZTA 2ZXQA 3T48A 1DKZA 2EFLA 4IM0A 3GI7A 4AZ7A 4EZQA 3HAHA 3D2FA 2OW6A 1GN9A 4IWOA 3O3MB 4FZOA 3QA8A 2YIAA 2F1BA 2OBLA 2ND0A 3D52A 3DX4A 3HAJA 2F7PA 3EJTA 3LLLA 1DKYA 4R5GA 3EJSA 3T4AG 4R5JA 3CVRA 4HR1A 2YL9A 1SU7A 1GNLA 3T47A 4EZUA 4R5KA 1OA1A 3LVTA 3CKDA 2KHOA 2YI8A 4EZRA 1E2UA 3CAZA 3LMFA 2WYIA 3QNJA 3OWGA 5KBPA 1HWWA 2YI9A 3M3WA 4D8JA 2Z8YA 4AZ5A 3QNIA 3F7WA 3QE6A 4AVMA 1HXKA 4NPHA 3QWEA 2PY6A 2RT6A 1WDZA 1X04A 2WINM 5FIGA 3EJUA 1I4DA 1ZYLA 1DKXA 4EZNA 2Z0VA 4IM3A 2F7OA 2FICA 2EFKA 2Z0OA 2YLAA 1TQTA 4JNEA 2ND1A 3ZEDA 2GF4A 2YL5A 4R5LA 5C5BA 3A98A 2F7RA 3I2WA 1PS3A 1I4TA 1E9VA 1LQ7A 4JL9A 1R34A 4KIKA 4EZVA
chains in the Genus database with same CATH topology
2X3XA 2EFKA 2Z0OA 3HAIA 2RAIA 3QWEA 4WPEA 3G9GA 3ACOA 3HAJA 3SYVA 1X03A 2Q12A 2X3WA 3LLLA 3Q84A 1WDZA 1X04A 1I4LA 2EFLA 2V0OA 3CAZA 1URUA 4BNEA 2RAJA 4H8SA 5C5BA 2Z0NA 2C08A 1I4DA 3I2WA 3DYTA 1I4TA 3ABHA 4DCNC 3Q0KA 2YKTA 2X3VA 3HAHA 3PLTA 2D1LA 1I49A 2Z0VA 4ATMA 2ELBA 3M3WA 4DYLA 1ZWWA 4FZSA 2D4CA 1Y2OA 3SOGA 4NQIA 4NSWA 4AKVA 2Q13A 2RAKA 3QNIA 4I1QA 3QE6A 4AVMA 2FICA 4WPCA 5C5BB 3OK8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X3X A;  2EFK A;  2Z0O A;  3HAI A;  2RAI A;  3QWE A;  4WPE A;  3G9G A;  3ACO A;  3HAJ A;  3SYV A;  1X03 A;  2Q12 A;  2X3W A;  3LLL A;  3Q84 A;  1WDZ A;  1X04 A;  1I4L A;  2EFL A;  2V0O A;  3CAZ A;  1URU A;  4BNE A;  2RAJ A;  4H8S A;  5C5B A;  2Z0N A;  2C08 A;  1I4D A;  3I2W A;  3DYT A;  1I4T A;  3ABH A;  4DCN C;  3Q0K A;  2YKT A;  2X3V A;  3HAH A;  3PLT A;  2D1L A;  1I49 A;  2Z0V A;  4ATM A;  2ELB A;  3M3W A;  4DYL A;  1ZWW A;  4FZS A;  2D4C A;  1Y2O A;  3SOG A;  4NQI A;  4NSW A;  4AKV A;  2Q13 A;  2RAK A;  3QNI A;  4I1Q A;  3QE6 A;  4AVM A;  2FIC A;  4WPC A;  5C5B B;  3OK8 A; 
#chains in the Genus database with same CATH topology
 2GAF D;  4HR1 B;  5FLE X;  2Q12 A;  4AZI A;  3I04 A;  4BNE A;  2EX3 B;  3Q0K A;  4ATM A;  2ELB A;  3B51 X;  3EJR A;  2PMR A;  4G6Q A;  4WPC A;  2F18 A;  4F01 A;  4JWE A;  1MJG A;  3O3O B;  3ER9 B;  4HY9 A;  4JWI A;  4AZG A;  4JLC A;  1JQK A;  4DYL A;  4R5I A;  1TQV A;  1YWM A;  3SOG A;  1QWU A;  3BVT A;  3T46 A;  3BUP A;  3RPM A;  4I1Q A;  2LM0 A;  3CZS A;  3DPO A;  2X5C A;  5TKY A;  2EWF A;  4AZC A;  2MI7 A;  4JN4 A;  1I4L A;  2ALW A;  2F1A A;  1OA0 A;  3KAV A;  1O7D B;  4FM3 A;  4DCN C;  4IWP A;  3BUQ A;  4UDY X;  4AZB A;  4IWQ A;  4EZZ A;  3D51 A;  2RAI A;  1U00 A;  4E81 A;  3ERC C;  3G9G A;  3UIT A;  1HTY A;  4KIK B;  4H8S A;  3DX0 A;  3BVX A;  1TQU A;  2GA9 D;  2OZN B;  4IW0 A;  2O0I 1;  4JWD A;  2YIV X;  4FZS A;  3D4Z A;  3CV5 A;  1QX1 A;  3DPQ A;  2F7Q A;  3KAW A;  3O3N B;  3ACO A;  3I01 A;  3DPP A;  3EJQ A;  2X3W A;  5E84 A;  2FYV A;  1R5E A;  1UPX A;  2V0O A;  3RV0 A;  3DDF A;  1SU8 A;  2X3V A;  1SU6 A;  2YIB A;  3T49 A;  3DX1 A;  2N3K A;  1URU A;  2RAJ A;  2JNK A;  2Z0N A;  4UDX X;  3PLT A;  4AZC B;  2YL6 A;  3BVW A;  3HAI A;  2OBM A;  4FZP A;  2WYH A;  3BUD A;  3SYV A;  1X03 A;  2QFF A;  4JWC A;  3DX3 A;  3ER8 C;  4H6I A;  1TQS A;  2C08 A;  2OW7 A;  3ABH A;  2YLL A;  4B9Q A;  4IM2 A;  3VEA A;  3L3O M;  3EJP A;  1R33 A;  4EZP A;  4EZX A;  3CZN A;  1QWN A;  4AZ6 A;  3D4Y A;  4H6H A;  3D2E A;  2D4C A;  4E3C A;  3C7N A;  5C5B B;  2X3X A;  3FD9 A;  3B52 X;  1O7D C;  2NCZ A;  2LXY A;  3BUB A;  3DYT A;  1W9M A;  1OAO A;  1I49 A;  2D1L A;  3I39 X;  4AZH A;  4PO2 A;  2Q13 A;  2RAK A;  4M0M A;  3D50 A;  3BLB A;  1TQW A;  2QKW A;  3B53 X;  2JNS A;  3BVU A;  3KDR A;  2YKT A;  2QXL A;  4EZW A;  1ZWW A;  4F00 A;  1Y2O A;  4NQI A;  4NSW A;  4HYB A;  2OO2 A;  4JNF A;  3BUI A;  4WPE A;  1E1D A;  3Q84 A;  4EZS A;  1SUF A;  3OHX M;  3BVV A;  3DX2 A;  3DDG A;  4EZO A;  2YL8 A;  4AKV A;  3L3P A;  4EZY A;  3VKH A;  3OK8 A;  3RV1 A;  3VEB A;  1GNT A;  4EZT A;  2ZXQ A;  3T48 A;  1DKZ A;  2EFL A;  4IM0 A;  3GI7 A;  4AZ7 A;  4EZQ A;  3HAH A;  3D2F A;  2OW6 A;  1GN9 A;  4IWO A;  3O3M B;  4FZO A;  3QA8 A;  2YIA A;  2F1B A;  2OBL A;  2ND0 A;  3D52 A;  3DX4 A;  3HAJ A;  2F7P A;  3EJT A;  3LLL A;  1DKY A;  4R5G A;  3EJS A;  3T4A G;  4R5J A;  3CVR A;  4HR1 A;  2YL9 A;  1SU7 A;  1GNL A;  3T47 A;  4EZU A;  4R5K A;  1OA1 A;  3LVT A;  3CKD A;  2KHO A;  2YI8 A;  4EZR A;  1E2U A;  3CAZ A;  3LMF A;  2WYI A;  3QNJ A;  3OWG A;  5KBP A;  1HWW A;  2YI9 A;  3M3W A;  4D8J A;  2Z8Y A;  4AZ5 A;  3QNI A;  3F7W A;  3QE6 A;  4AVM A;  1HXK A;  4NPH A;  3QWE A;  2PY6 A;  2RT6 A;  1WDZ A;  1X04 A;  2WIN M;  5FIG A;  3EJU A;  1I4D A;  1ZYL A;  1DKX A;  4EZN A;  2Z0V A;  4IM3 A;  2F7O A;  2FIC A;  2EFK A;  2Z0O A;  2YLA A;  1TQT A;  4JNE A;  2ND1 A;  3ZED A;  2GF4 A;  2YL5 A;  4R5L A;  5C5B A;  3A98 A;  2F7R A;  3I2W A;  1PS3 A;  1I4T A;  1E9V A;  1LQ7 A;  4JL9 A;  1R34 A;  4KIK A;  4EZV A; 
#chains in the Genus database with same CATH homology
 2X3X A;  2EFK A;  2Z0O A;  3HAI A;  2RAI A;  3QWE A;  4WPE A;  3G9G A;  3ACO A;  3HAJ A;  3SYV A;  1X03 A;  2Q12 A;  2X3W A;  3LLL A;  3Q84 A;  1WDZ A;  1X04 A;  1I4L A;  2EFL A;  2V0O A;  3CAZ A;  1URU A;  4BNE A;  2RAJ A;  4H8S A;  5C5B A;  2Z0N A;  2C08 A;  1I4D A;  3I2W A;  3DYT A;  1I4T A;  3ABH A;  4DCN C;  3Q0K A;  2YKT A;  2X3V A;  3HAH A;  3PLT A;  2D1L A;  1I49 A;  2Z0V A;  4ATM A;  2ELB A;  3M3W A;  4DYL A;  1ZWW A;  4FZS A;  2D4C A;  1Y2O A;  3SOG A;  4NQI A;  4NSW A;  4AKV A;  2Q13 A;  2RAK A;  3QNI A;  4I1Q A;  3QE6 A;  4AVM A;  2FIC A;  4WPC A;  5C5B B;  3OK8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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