2KR6A

Solution structure of presenilin-1 ctf subunit
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
176
structure length
176
Chain Sequence
MVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution structure of presenilin-1 CTF subunit
rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Presenilin-1
total genus 28
structure length 176
sequence length 176
ec nomenclature ec 3.4.23.-:
pdb deposition date 2009-12-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.100 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin A; domain 1 2kr6A01
2KR6A
chains in the Genus database with same CATH superfamily
4CXAB 2C6TB 3TW6A 2LW4A 5IDPB 4BCQB 1OIUB 2QF7A 3HZJA 4F7LB 4EOSB 2ZPFB 3BLQB 3X20B 1IREB 3F5XB 1UGQB 3QHRB 3DDPB 1OIYB 1GUXB 1OL1B 3QWLA 2W96A 1H1PB 2PK9B 1OL2B 4F6SB 1AD6A 3WVDB 4EOLB 1OGUB 4CFWB 2CZ6B 4NC6A 5LMKB 1O9KB 1H1QB 2PK2A 1JSTB 4EOIB 4AKGA 3DOGB 3TN8B 4G6LB 1VINA 1AHJB 3QZ5B 4JX6A 2WIPB 3MY5B 2WXVB 1H4LD 2QDYB 1OKWB 2C5VB 3POMA 2C5XB 1E9HB 4EC8B 2PHGA 5HBHB 3K7AM 5EFQB 3BG5A 4II5B 4KRDB 3HBLA 3O0GD 4MFDA 4F7NB 1XO2A 2CZ0B 2DMEA 1GUXA 1UNLD 2WIHB 3MI9B 2CCIB 2KR6A 4HNVA 4F6WB 4AKHA 5DQVA 1V29B 4EOOB 4ZGJB 2UZBB 2R7GA 2BS2A 2DD4B 3WVEB 2B9RA 4BXXX 2W9ZA 4EOPB 3X24B 3BG3A 4BCFB 3NDQA 4ZGEB 4Z6YA 2I53A 1H28B 5BNJB 4OGRB 4KRCB 2F2CA 4YOSA 2PJQA 4ZGDB 2DPPB 3DL1A 2G77A 2BPMB 2ZPEB 3QYHB 4BCOB 1KXUA 4BCGB 4RODA 2JGZB 2UZLB 4HLQA 4QSHA 3A8HB 3A8GB 3EOCB 2UZDB 1FKMA 4CFXB 1P5EB 4CFMB 1D3UB 1UGRB 3A8OB 5ICPB 2ZPHB 3RGFB 1G3NC 3G33B 1N4MA 3BG9A 4TTHA 4MIMA 3HO8A 3X26B 2QGSA 4HL4A 1C9BA 3M03A 4I3ZB 2IN3A 2KMGA 4ELLA 4OB3B 4BCKB 2UUEB 5HVYB 3GTMS 3B57A 2ZPBB 5HNBB 4AI6A 4EOJB 1JSUB 1H1SB 4F7JB 3BHUB 4HNUA 2QQ8A 3VKGA 1PKDB 3KHIA 4F6UB 4HNTA 2WMAB 4JX4A 1VOLA 5L2WB 1GH6B 4BCPB 2W2HA 5IF1B 4CFVB 2AHJB 1H1RB 4EOQB 4EONB 3H4CA 5HBJB 4BCIB 2CYZB 2DXCB 5CEIB 4ELJA 2WHBB 4Y72B 3VKHA 2C5OB 4OR5B 2CCHB 5LQFB 3EIDB 2CJMB 5ACBA 4M6VA 4UN0A 4F70B 4NSTB 1F5QB 1UGPB 2UZEB 2I40B 4MFEA 3HB9A 4LOCA 3VYGB 1H24B 4CFUD 4JX5A 2IVXA 3TNWB 1TD6A 1ENWA 4FM4B 5DQWA 1URCB 2IW6B 1E7PA 5CYIB 4EOKB 1W98B 2ZPGB 4OB0B 4EOMB 1QMZB 2BKZB 4YOOA 3BLHB 3QHWB 4BCMD 3TNIB 2D0QB 1UNGD 2PMIB 3LQ5B 5HQ0B 4YOZA 2V22B 2X1NB 2EUFA 4CFNB 3QXEB 3MIAB 4BCJB 2QFZA 1UNHD 2W9FA 4ROCA 2C5NB 3DTOA 2C4GB 2ZZDB 3DJBA 3QYGB 4CFUB 1H26B 1H25B 3TNHB 4BBRM 3A8MB 1QLBA 4ROEA 3QYEA 5IHYA 2W99A 2WFYB 3QYBA 3MY1B 4BCMB 1ZP2A 2WPAB 1FINB 3BHTB 1OKVB 4FX3B 4BBSM 2ZCFB 4OB1B 4BY7X 1AISB 3VYHB 5EJCA 2WMBB 2WJ9A 1UGSB 1VYWB 2G9XB 4YC3B 3X28B 3PO3S 4BCND 4AKIA 1GY3B 2WEVB 3BHVB 4OB2B 4EORB 5I5ZB 2QDJA 4IMYB 4BCQD 2CZ7B 3DDQB 5FGKB 3BLRB 2DD5B 1H27B 4F7SB 3X25B 1FVVB 3QZ9B 3TW7A 3HHTB 1JOWA 2IW9B 1OI9B 2BS4A 2BS3A 1TFBA 2IW8B 3A8LB 4CRLB 1O9KA 4BCHB 3EJ1B 2ZPIB 1JKWA 5IDNB 2CZ1B 5HBEB 4BY1X 4BCNB 2DXBB 1BU2A 4EC9B
chains in the Genus database with same CATH topology
2KR6A 4HNVA 2ZZDB 4HNUA 2QQ8A 3TW6A 3VKGA 3QYGB 2QF7A 3HZJA 4AKHA 2ZPFB 3KHIA 4HNTA 4BBRM 1V29B 4ZGJB 3A8MB 1QLBA 3QYEA 4JX4A 3X20B 1IREB 1UGQB 2BS2A 2DD4B 3QYBA 3WVEB 2AHJB 3QWLA 3H4CA 3X24B 2CYZB 3BG3A 2DXCB 3WVDB 4BBSM 4ELJA 4ZGEB 4Z6YA 2ZCFB 3VKHA 4OB1B 3VYHB 5EJCA 2CZ6B 4NC6A 4ZGDB 2DPPB 2WJ9A 3DL1A 1UGSB 2G77A 4M6VA 4AKGA 2ZPEB 3QYHB 1UGPB 3X28B 1AHJB 3QZ5B 4HLQA 4MFEA 3HB9A 4QSHA 4JX6A 4AKIA 3A8HB 4LOCA 4OB2B 3A8GB 3VYGB 1FKMA 2QDJA 2QDYB 4JX5A 2CZ7B 2DD5B 1UGRB 4FM4B 3A8OB 2ZPHB 3X25B 3QZ9B 3BG9A 3TW7A 1E7PA 3HHTB 4MIMA 2ZPGB 4OB0B 3HO8A 3X26B 2BS4A 2BS3A 3BG5A 4HL4A 3A8LB 2D0QB 3HBLA 2KMGA 4MFDA 4OB3B 2ZPIB 2CZ1B 2ZPBB 3QXEB 2CZ0B 4AI6A 2DXBB 2QFZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KR6 A; 
#chains in the Genus database with same CATH topology
 4CXA B;  2C6T B;  3TW6 A;  2LW4 A;  5IDP B;  4BCQ B;  1OIU B;  2QF7 A;  3HZJ A;  4F7L B;  4EOS B;  2ZPF B;  3BLQ B;  3X20 B;  1IRE B;  3F5X B;  1UGQ B;  3QHR B;  3DDP B;  1OIY B;  1GUX B;  1OL1 B;  3QWL A;  2W96 A;  1H1P B;  2PK9 B;  1OL2 B;  4F6S B;  1AD6 A;  3WVD B;  4EOL B;  1OGU B;  4CFW B;  2CZ6 B;  4NC6 A;  5LMK B;  1O9K B;  1H1Q B;  2PK2 A;  1JST B;  4EOI B;  4AKG A;  3DOG B;  3TN8 B;  4G6L B;  1VIN A;  1AHJ B;  3QZ5 B;  4JX6 A;  2WIP B;  3MY5 B;  2WXV B;  1H4L D;  2QDY B;  1OKW B;  2C5V B;  3POM A;  2C5X B;  1E9H B;  4EC8 B;  2PHG A;  5HBH B;  3K7A M;  5EFQ B;  3BG5 A;  4II5 B;  4KRD B;  3HBL A;  3O0G D;  4MFD A;  4F7N B;  1XO2 A;  2CZ0 B;  2DME A;  1GUX A;  1UNL D;  2WIH B;  3MI9 B;  2CCI B;  2KR6 A;  4HNV A;  4F6W B;  4AKH A;  5DQV A;  1V29 B;  4EOO B;  4ZGJ B;  2UZB B;  2R7G A;  2BS2 A;  2DD4 B;  3WVE B;  2B9R A;  4BXX X;  2W9Z A;  4EOP B;  3X24 B;  3BG3 A;  4BCF B;  3NDQ A;  4ZGE B;  4Z6Y A;  2I53 A;  1H28 B;  5BNJ B;  4OGR B;  4KRC B;  2F2C A;  4YOS A;  2PJQ A;  4ZGD B;  2DPP B;  3DL1 A;  2G77 A;  2BPM B;  2ZPE B;  3QYH B;  4BCO B;  1KXU A;  4BCG B;  4ROD A;  2JGZ B;  2UZL B;  4HLQ A;  4QSH A;  3A8H B;  3A8G B;  3EOC B;  2UZD B;  1FKM A;  4CFX B;  1P5E B;  4CFM B;  1D3U B;  1UGR B;  3A8O B;  5ICP B;  2ZPH B;  3RGF B;  1G3N C;  3G33 B;  1N4M A;  3BG9 A;  4TTH A;  4MIM A;  3HO8 A;  3X26 B;  2QGS A;  4HL4 A;  1C9B A;  3M03 A;  4I3Z B;  2IN3 A;  2KMG A;  4ELL A;  4OB3 B;  4BCK B;  2UUE B;  5HVY B;  3GTM S;  3B57 A;  2ZPB B;  5HNB B;  4AI6 A;  4EOJ B;  1JSU B;  1H1S B;  4F7J B;  3BHU B;  4HNU A;  2QQ8 A;  3VKG A;  1PKD B;  3KHI A;  4F6U B;  4HNT A;  2WMA B;  4JX4 A;  1VOL A;  5L2W B;  1GH6 B;  4BCP B;  2W2H A;  5IF1 B;  4CFV B;  2AHJ B;  1H1R B;  4EOQ B;  4EON B;  3H4C A;  5HBJ B;  4BCI B;  2CYZ B;  2DXC B;  5CEI B;  4ELJ A;  2WHB B;  4Y72 B;  3VKH A;  2C5O B;  4OR5 B;  2CCH B;  5LQF B;  3EID B;  2CJM B;  5ACB A;  4M6V A;  4UN0 A;  4F70 B;  4NST B;  1F5Q B;  1UGP B;  2UZE B;  2I40 B;  4MFE A;  3HB9 A;  4LOC A;  3VYG B;  1H24 B;  4CFU D;  4JX5 A;  2IVX A;  3TNW B;  1TD6 A;  1ENW A;  4FM4 B;  5DQW A;  1URC B;  2IW6 B;  1E7P A;  5CYI B;  4EOK B;  1W98 B;  2ZPG B;  4OB0 B;  4EOM B;  1QMZ B;  2BKZ B;  4YOO A;  3BLH B;  3QHW B;  4BCM D;  3TNI B;  2D0Q B;  1UNG D;  2PMI B;  3LQ5 B;  5HQ0 B;  4YOZ A;  2V22 B;  2X1N B;  2EUF A;  4CFN B;  3QXE B;  3MIA B;  4BCJ B;  2QFZ A;  1UNH D;  2W9F A;  4ROC A;  2C5N B;  3DTO A;  2C4G B;  2ZZD B;  3DJB A;  3QYG B;  4CFU B;  1H26 B;  1H25 B;  3TNH B;  4BBR M;  3A8M B;  1QLB A;  4ROE A;  3QYE A;  5IHY A;  2W99 A;  2WFY B;  3QYB A;  3MY1 B;  4BCM B;  1ZP2 A;  2WPA B;  1FIN B;  3BHT B;  1OKV B;  4FX3 B;  4BBS M;  2ZCF B;  4OB1 B;  4BY7 X;  1AIS B;  3VYH B;  5EJC A;  2WMB B;  2WJ9 A;  1UGS B;  1VYW B;  2G9X B;  4YC3 B;  3X28 B;  3PO3 S;  4BCN D;  4AKI A;  1GY3 B;  2WEV B;  3BHV B;  4OB2 B;  4EOR B;  5I5Z B;  2QDJ A;  4IMY B;  4BCQ D;  2CZ7 B;  3DDQ B;  5FGK B;  3BLR B;  2DD5 B;  1H27 B;  4F7S B;  3X25 B;  1FVV B;  3QZ9 B;  3TW7 A;  3HHT B;  1JOW A;  2IW9 B;  1OI9 B;  2BS4 A;  2BS3 A;  1TFB A;  2IW8 B;  3A8L B;  4CRL B;  1O9K A;  4BCH B;  3EJ1 B;  2ZPI B;  1JKW A;  5IDN B;  2CZ1 B;  5HBE B;  4BY1 X;  4BCN B;  2DXB B;  1BU2 A;  4EC9 B; 
#chains in the Genus database with same CATH homology
 2KR6 A;  4HNV A;  2ZZD B;  4HNU A;  2QQ8 A;  3TW6 A;  3VKG A;  3QYG B;  2QF7 A;  3HZJ A;  4AKH A;  2ZPF B;  3KHI A;  4HNT A;  4BBR M;  1V29 B;  4ZGJ B;  3A8M B;  1QLB A;  3QYE A;  4JX4 A;  3X20 B;  1IRE B;  1UGQ B;  2BS2 A;  2DD4 B;  3QYB A;  3WVE B;  2AHJ B;  3QWL A;  3H4C A;  3X24 B;  2CYZ B;  3BG3 A;  2DXC B;  3WVD B;  4BBS M;  4ELJ A;  4ZGE B;  4Z6Y A;  2ZCF B;  3VKH A;  4OB1 B;  3VYH B;  5EJC A;  2CZ6 B;  4NC6 A;  4ZGD B;  2DPP B;  2WJ9 A;  3DL1 A;  1UGS B;  2G77 A;  4M6V A;  4AKG A;  2ZPE B;  3QYH B;  1UGP B;  3X28 B;  1AHJ B;  3QZ5 B;  4HLQ A;  4MFE A;  3HB9 A;  4QSH A;  4JX6 A;  4AKI A;  3A8H B;  4LOC A;  4OB2 B;  3A8G B;  3VYG B;  1FKM A;  2QDJ A;  2QDY B;  4JX5 A;  2CZ7 B;  2DD5 B;  1UGR B;  4FM4 B;  3A8O B;  2ZPH B;  3X25 B;  3QZ9 B;  3BG9 A;  3TW7 A;  1E7P A;  3HHT B;  4MIM A;  2ZPG B;  4OB0 B;  3HO8 A;  3X26 B;  2BS4 A;  2BS3 A;  3BG5 A;  4HL4 A;  3A8L B;  2D0Q B;  3HBL A;  2KMG A;  4MFD A;  4OB3 B;  2ZPI B;  2CZ1 B;  2ZPB B;  3QXE B;  2CZ0 B;  4AI6 A;  2DXB B;  2QFZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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