2KR6A

Solution structure of presenilin-1 ctf subunit
Total Genus 28

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
176
structure length
176
Chain Sequence
MVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase
source organism Homo sapiens
publication title Solution structure of presenilin-1 CTF subunit
rcsb
molecule keywords Presenilin-1
total genus 28
structure length 176
sequence length 176
ec nomenclature ec 3.4.23.-:
pdb deposition date 2009-12-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.100 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin A; domain 1 2kr6A01
2KR6A
chains in the Genus database with same CATH superfamily
3EOCB 4LOCA 3VKHA 5DQWA 3BLHB 3TNIB 2ZPFB 3BG9A 1OL1B 4KRDB 2IW6B 4OB1B 2KMGA 3PO3S 4BCQD 4F7LB 3WVEB 2R7GA 4JX4A 4HL4A 1N4MA 3KHIA 1QMZB 4EC9B 2UZEB 3F5XB 4BCPB 2W9ZA 4BXXX 2WMAB 2ZPGB 2ZPEB 1VINA 2EUFA 5DQVA 2QGSA 4ROCA 2B9RA 4IMYB 3QZ5B 3WVDB 2ZPIB 1H1RB 4Y72B 1AISB 3DL1A 5FGKB 3QYGB 1VYWB 5IHYA 4CFUD 2PK2A 3LQ5B 1P5EB 4F6SB 2X1NB 2QF7A 1F5QB 2C5VB 2IN3A 1C9BA 4BCNB 1TD6A 4BCIB 1ZP2A 2W9FA 4BY7X 3QXEB 2WJ9A 4ZGDB 3TNWB 4EONB 4BCOB 1JSUB 4CFXB 3K7AM 3EJ1B 4TTHA 3X25B 4HNUA 2C4GB 4AKIA 4ROEA 3BHVB 2IW8B 4YC3B 5EFQB 4EOIB 5HBHB 2CCIB 3HHTB 4FX3B 1KXUA 4M6VA 1W98B 3MY1B 4NC6A 4F70B 4ELJA 1FKMA 1H26B 1JOWA 1E7PA 1UGQB 2WPAB 4I3ZB 4BCKB 3BG3A 4AKHA 3DOGB 5LMKB 2W96A 2C5NB 4EOOB 2W2HA 1UNLD 1AD6A 2QQ8A 4NSTB 2QDYB 4UN0A 4CFMB 2W99A 1OI9B 4YOSA 3TW7A 3DJBA 4BCHB 4EOJB 2BS3A 2C5OB 1OIYB 3B57A 4II5B 4OB2B 2WEVB 4RODA 4OGRB 3GTMS 2UZLB 3BLQB 5HNBB 2PHGA 4EC8B 1H24B 2PJQA 1D3UB 4BCMD 1OKWB 5IDNB 5CYIB 1O9KB 2D0QB 3POMA 2QDJA 3DDQB 2I40B 3A8MB 1JSTB 4BCQB 2G9XB 3A8OB 3NDQA 1UGPB 4BCGB 3TNHB 4JX5A 2QFZA 1H1QB 1G3NC 2CZ0B 4F7JB 1OL2B 4EOLB 4BY1X 1TFBA 2CZ6B 3BHTB 1GY3B 5HVYB 2LW4A 4YOOA 4OB0B 1XO2A 3TW6A 2BS2A 3MIAB 4EOPB 2C5XB 2UZBB 3BLRB 4HLQA 2IW9B 2CJMB 3QYEA 2WIPB 1BU2A 4ELLA 4BCFB 2DD4B 2DXCB 1OKVB 2WXVB 4CFUB 3TN8B 4CFWB 4BBSM 4ZGEB 3MI9B 2BS4A 3QHRB 1UGRB 1UNGD 1H27B 2F2CA 3QZ9B 3X26B 4EOQB 3BHUB 3VKGA 1H4LD 5HBJB 3HZJA 4G6LB 3RGFB 4CRLB 4F7NB 4FM4B 2I53A 3QYBA 1O9KA 2ZZDB 1JKWA 4AKGA 2PMIB 3HO8A 5HQ0B 2G77A 1FINB 2CCHB 3DDPB 3HBLA 2UUEB 4QSHA 2AHJB 5I5ZB 3QHWB 3HB9A 2DD5B 1UGSB 1H25B 1OIUB 5LQFB 1IREB 2WHBB 2JGZB 1GH6B 2C6TB 4JX6A 2KR6A 4Z6YA 3MY5B 3EIDB 2DPPB 4EOMB 4MIMA 2WMBB 3X28B 1PKDB 5IF1B 4F7SB 1GUXB 3X24B 2WIHB 2BPMB 4OB3B 1OGUB 5ACBA 4KRCB 2CZ1B 4BCND 2DMEA 5HBEB 5EJCA 3A8LB 2CYZB 3O0GD 2UZDB 1FVVB 1V29B 1H28B 3H4CA 5BNJB 4CXAB 4MFEA 2DXBB 3X20B 1UNHD 1VOLA 4YOZA 1URCB 4EOSB 1E9HB 4BBRM 4HNVA 4F6WB 4BCMB 5IDPB 4CFVB 4OR5B 1H1SB 4BCJB 2BKZB 1ENWA 2CZ7B 3QYHB 2ZPHB 4AI6A 3VYHB 2IVXA 2ZCFB 3A8HB 5L2WB 1GUXA 3G33B 3QWLA 3DTOA 4F6UB 2PK9B 4MFDA 2WFYB 2V22B 1AHJB 1QLBA 5ICPB 3M03A 4EORB 5CEIB 4HNTA 1H1PB 2ZPBB 4ZGJB 4EOKB 3BG5A 3VYGB 4CFNB 3A8GB
chains in the Genus database with same CATH topology
3X25B 4HNUA 4OB3B 4AKIA 4LOCA 4JX5A 3VKHA 2QFZA 2CZ0B 2CZ1B 2CZ6B 2ZPFB 3BG9A 5EJCA 3A8LB 2CYZB 3HHTB 4OB1B 4M6VA 4OB0B 2KMGA 3TW6A 2BS2A 4NC6A 4ELJA 1FKMA 3WVEB 4JX4A 4HL4A 4HLQA 1V29B 3KHIA 3H4CA 1E7PA 3QYEA 1UGQB 4MFEA 2DXBB 2DD4B 2DXCB 3BG3A 3X20B 4AKHA 4BBSM 4ZGEB 2ZPGB 2ZPEB 2BS4A 1UGRB 3QZ9B 3X26B 3VKGA 3QZ5B 4BBRM 4HNVA 3WVDB 2QQ8A 2ZPIB 3HZJA 4FM4B 3QYBA 2QDYB 3DL1A 2ZZDB 3TW7A 3QYGB 2CZ7B 3QYHB 2ZPHB 2BS3A 4AKGA 3HO8A 4AI6A 3VYHB 2G77A 2ZCFB 3A8HB 4QSHA 3HBLA 2AHJB 3QWLA 4OB2B 2QF7A 3HB9A 4MFDA 2DD5B 1UGSB 1IREB 1AHJB 1QLBA 4JX6A 2KR6A 4Z6YA 2D0QB 4HNTA 2QDJA 2DPPB 3A8MB 2ZPBB 4MIMA 4ZGJB 3X28B 3QXEB 2WJ9A 4ZGDB 3A8OB 3BG5A 3VYGB 1UGPB 3A8GB 3X24B
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2KR6 A; 
#chains in the Genus database with same CATH topology
 3EOC B;  4LOC A;  3VKH A;  5DQW A;  3BLH B;  3TNI B;  2ZPF B;  3BG9 A;  1OL1 B;  4KRD B;  2IW6 B;  4OB1 B;  2KMG A;  3PO3 S;  4BCQ D;  4F7L B;  3WVE B;  2R7G A;  4JX4 A;  4HL4 A;  1N4M A;  3KHI A;  1QMZ B;  4EC9 B;  2UZE B;  3F5X B;  4BCP B;  2W9Z A;  4BXX X;  2WMA B;  2ZPG B;  2ZPE B;  1VIN A;  2EUF A;  5DQV A;  2QGS A;  4ROC A;  2B9R A;  4IMY B;  3QZ5 B;  3WVD B;  2ZPI B;  1H1R B;  4Y72 B;  1AIS B;  3DL1 A;  5FGK B;  3QYG B;  1VYW B;  5IHY A;  4CFU D;  2PK2 A;  3LQ5 B;  1P5E B;  4F6S B;  2X1N B;  2QF7 A;  1F5Q B;  2C5V B;  2IN3 A;  1C9B A;  4BCN B;  1TD6 A;  4BCI B;  1ZP2 A;  2W9F A;  4BY7 X;  3QXE B;  2WJ9 A;  4ZGD B;  3TNW B;  4EON B;  4BCO B;  1JSU B;  4CFX B;  3K7A M;  3EJ1 B;  4TTH A;  3X25 B;  4HNU A;  2C4G B;  4AKI A;  4ROE A;  3BHV B;  2IW8 B;  4YC3 B;  5EFQ B;  4EOI B;  5HBH B;  2CCI B;  3HHT B;  4FX3 B;  1KXU A;  4M6V A;  1W98 B;  3MY1 B;  4NC6 A;  4F70 B;  4ELJ A;  1FKM A;  1H26 B;  1JOW A;  1E7P A;  1UGQ B;  2WPA B;  4I3Z B;  4BCK B;  3BG3 A;  4AKH A;  3DOG B;  5LMK B;  2W96 A;  2C5N B;  4EOO B;  2W2H A;  1UNL D;  1AD6 A;  2QQ8 A;  4NST B;  2QDY B;  4UN0 A;  4CFM B;  2W99 A;  1OI9 B;  4YOS A;  3TW7 A;  3DJB A;  4BCH B;  4EOJ B;  2BS3 A;  2C5O B;  1OIY B;  3B57 A;  4II5 B;  4OB2 B;  2WEV B;  4ROD A;  4OGR B;  3GTM S;  2UZL B;  3BLQ B;  5HNB B;  2PHG A;  4EC8 B;  1H24 B;  2PJQ A;  1D3U B;  4BCM D;  1OKW B;  5IDN B;  5CYI B;  1O9K B;  2D0Q B;  3POM A;  2QDJ A;  3DDQ B;  2I40 B;  3A8M B;  1JST B;  4BCQ B;  2G9X B;  3A8O B;  3NDQ A;  1UGP B;  4BCG B;  3TNH B;  4JX5 A;  2QFZ A;  1H1Q B;  1G3N C;  2CZ0 B;  4F7J B;  1OL2 B;  4EOL B;  4BY1 X;  1TFB A;  2CZ6 B;  3BHT B;  1GY3 B;  5HVY B;  2LW4 A;  4YOO A;  4OB0 B;  1XO2 A;  3TW6 A;  2BS2 A;  3MIA B;  4EOP B;  2C5X B;  2UZB B;  3BLR B;  4HLQ A;  2IW9 B;  2CJM B;  3QYE A;  2WIP B;  1BU2 A;  4ELL A;  4BCF B;  2DD4 B;  2DXC B;  1OKV B;  2WXV B;  4CFU B;  3TN8 B;  4CFW B;  4BBS M;  4ZGE B;  3MI9 B;  2BS4 A;  3QHR B;  1UGR B;  1UNG D;  1H27 B;  2F2C A;  3QZ9 B;  3X26 B;  4EOQ B;  3BHU B;  3VKG A;  1H4L D;  5HBJ B;  3HZJ A;  4G6L B;  3RGF B;  4CRL B;  4F7N B;  4FM4 B;  2I53 A;  3QYB A;  1O9K A;  2ZZD B;  1JKW A;  4AKG A;  2PMI B;  3HO8 A;  5HQ0 B;  2G77 A;  1FIN B;  2CCH B;  3DDP B;  3HBL A;  2UUE B;  4QSH A;  2AHJ B;  5I5Z B;  3QHW B;  3HB9 A;  2DD5 B;  1UGS B;  1H25 B;  1OIU B;  5LQF B;  1IRE B;  2WHB B;  2JGZ B;  1GH6 B;  2C6T B;  4JX6 A;  2KR6 A;  4Z6Y A;  3MY5 B;  3EID B;  2DPP B;  4EOM B;  4MIM A;  2WMB B;  3X28 B;  1PKD B;  5IF1 B;  4F7S B;  1GUX B;  3X24 B;  2WIH B;  2BPM B;  4OB3 B;  1OGU B;  5ACB A;  4KRC B;  2CZ1 B;  4BCN D;  2DME A;  5HBE B;  5EJC A;  3A8L B;  2CYZ B;  3O0G D;  2UZD B;  1FVV B;  1V29 B;  1H28 B;  3H4C A;  5BNJ B;  4CXA B;  4MFE A;  2DXB B;  3X20 B;  1UNH D;  1VOL A;  4YOZ A;  1URC B;  4EOS B;  1E9H B;  4BBR M;  4HNV A;  4F6W B;  4BCM B;  5IDP B;  4CFV B;  4OR5 B;  1H1S B;  4BCJ B;  2BKZ B;  1ENW A;  2CZ7 B;  3QYH B;  2ZPH B;  4AI6 A;  3VYH B;  2IVX A;  2ZCF B;  3A8H B;  5L2W B;  1GUX A;  3G33 B;  3QWL A;  3DTO A;  4F6U B;  2PK9 B;  4MFD A;  2WFY B;  2V22 B;  1AHJ B;  1QLB A;  5ICP B;  3M03 A;  4EOR B;  5CEI B;  4HNT A;  1H1P B;  2ZPB B;  4ZGJ B;  4EOK B;  3BG5 A;  3VYG B;  4CFN B;  3A8G B; 
#chains in the Genus database with same CATH homology
 3X25 B;  4HNU A;  4OB3 B;  4AKI A;  4LOC A;  4JX5 A;  3VKH A;  2QFZ A;  2CZ0 B;  2CZ1 B;  2CZ6 B;  2ZPF B;  3BG9 A;  5EJC A;  3A8L B;  2CYZ B;  3HHT B;  4OB1 B;  4M6V A;  4OB0 B;  2KMG A;  3TW6 A;  2BS2 A;  4NC6 A;  4ELJ A;  1FKM A;  3WVE B;  4JX4 A;  4HL4 A;  4HLQ A;  1V29 B;  3KHI A;  3H4C A;  1E7P A;  3QYE A;  1UGQ B;  4MFE A;  2DXB B;  2DD4 B;  2DXC B;  3BG3 A;  3X20 B;  4AKH A;  4BBS M;  4ZGE B;  2ZPG B;  2ZPE B;  2BS4 A;  1UGR B;  3QZ9 B;  3X26 B;  3VKG A;  3QZ5 B;  4BBR M;  4HNV A;  3WVD B;  2QQ8 A;  2ZPI B;  3HZJ A;  4FM4 B;  3QYB A;  2QDY B;  3DL1 A;  2ZZD B;  3TW7 A;  3QYG B;  2CZ7 B;  3QYH B;  2ZPH B;  2BS3 A;  4AKG A;  3HO8 A;  4AI6 A;  3VYH B;  2G77 A;  2ZCF B;  3A8H B;  4QSH A;  3HBL A;  2AHJ B;  3QWL A;  4OB2 B;  2QF7 A;  3HB9 A;  4MFD A;  2DD5 B;  1UGS B;  1IRE B;  1AHJ B;  1QLB A;  4JX6 A;  2KR6 A;  4Z6Y A;  2D0Q B;  4HNT A;  2QDJ A;  2DPP B;  3A8M B;  2ZPB B;  4MIM A;  4ZGJ B;  3X28 B;  3QXE B;  2WJ9 A;  4ZGD B;  3A8O B;  3BG5 A;  3VYG B;  1UGP B;  3A8G B;  3X24 B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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