2ND0A

Solution nmr structures of brd4 et domain with lana peptide
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
83
structure length
83
Chain Sequence
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
pubmed doi rcsb
molecule tags Transcription/viral protein
source organism Homo sapiens
molecule keywords Bromodomain-containing protein 4
total genus 27
structure length 83
sequence length 83
ec nomenclature
pdb deposition date 2016-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF17035 BET Bromodomain extra-terminal - transcription regulation
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.220 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 2nd0A01
2NCZA 2ND1A 2JNSA 2ND0A 2N3KA
chains in the Genus database with same CATH superfamily
5C5BA 3DPPA 3F7WA 1TQTA 2V0OA 4JWIA 2EWFA 1PS3A 4HYBA 2D1LA 1DKXA 4JWDA 3OK8A 3T4AG 4IWPA 2JNKA 3O3NB 3HAJA 3OWGA 3Q84A 2C08A 3DX4A 3QE6A 4EZRA 4HR1B 2F18A 4BNEA 4DYLA 4AKVA 3CVRA 3VEAA 4IM2A 1ZWWA 4ATMA 1HTYA 4KIKA 4G6QA 4WPEA 2N3KA 1OA1A 1TQWA 4EZVA 2QXLA 2Q12A 3G9GA 2WINM 3BUPA 2EFKA 5FIGA 3O3MB 1O7DC 1TQVA 1I4TA 5FLEX 3LLLA 3I01A 3BVUA 3DDFA 1TQUA 3PLTA 1X04A 2YL5A 2F7PA 1LQ7A 2OZNB 4D8JA 1YWMA 3ER8C 2ELBA 4WPCA 2EX3B 1E2UA 4EZXA 2OW6A 3CV5A 1I49A 4AZHA 4DCNC 3D52A 3QWEA 2YIVX 2ND1A 3I04A 4AZCB 3D2FA 5C5BB 1Y2OA 2YKTA 2QKWA 2RAJA 1W9MA 3D4YA 4H6IA 4EZUA 2NCZA 3T49A 3DX1A 3VKHA 2X3WA 4UDYX 2QFFA 2GA9D 4F01A 3QNJA 2RAIA 3GI7A 2GF4A 3L3PA 3CZNA 2Z8YA 4AZ7A 4IM0A 4KIKB 3HAHA 4FZPA 3T48A 3ZEDA 2YIAA 1X03A 2MI7A 3EJUA 2D4CA 2Q13A 3LVTA 3CZSA 3D4ZA 4H6HA 5E84A 2YIBA 1R33A 3BUQA 3SOGA 1GN9A 1WDZA 2YI8A 3B51X 3RPMA 4IWQA 4NQIA 4B9QA 3Q0KA 3FD9A 2X5CA 3EJTA 3QNIA 1SU7A 4I1QA 3EJSA 2PMRA 2JNSA 2YLLA 3DX0A 3BVVA 3BUIA 3QA8A 2X3XA 3EJPA 2OW7A 3ACOA 4PO2A 4JWCA 4R5LA 4AVMA 2F7QA 2YL8A 2Z0NA 3EJQA 3A98A 4R5GA 2Z0OA 1QWUA 4IWOA 2YI9A 4JLCA 1R34A 2ALWA 3CKDA 3DDGA 4HY9A 1E1DA 1O7DB 4AZIA 2OO2A 1QWNA 2KHOA 3DPOA 4JL9A 1R5EA 4AZ6A 1HWWA 2YLAA 4AZGA 3VEBA 2YL9A 2F1AA 3ER9B 1OA0A 4IM3A 4AZ5A 3DYTA 3D51A 3B52X 4EZWA 4H8SA 4EZTA 4FM3A 2YL6A 5TKYA 3M3WA 3BUBA 1U00A 2EFLA 2FYVA 2OBMA 4EZZA 2LM0A 1DKZA 2O0I1 1SU6A 1SUFA 3BVXA 3D50A 3OHXM 2WYIA 2RT6A 3C7NA 4IW0A 1OAOA 4EZOA 3EJRA 2WYHA 3L3OM 3CAZA 2LXYA 2RAKA 4FZSA 4EZSA 1TQSA 4F00A 2X3VA 3BVTA 2GAFD 1GNTA 3ABHA 4JWEA 4AZBA 2F7RA 3SYVA 3BVWA 4HR1A 1HXKA 3KDRA 4JNEA 3O3OB 1I4DA 1DKYA 2PY6A 3HAIA 3ERCC 3DX2A 3D2EA 4EZYA 3I2WA 4JNFA 4NSWA 4R5KA 3LMFA 3RV1A 1JQKA 4UDXX 4JN4A 3I39X 1E9VA 2F7OA 3KAWA 1QX1A 1GNLA 1I4LA 3KAVA 1UPXA 4EZPA 1ZYLA 2ND0A 2Z0VA 3T46A 2OBLA 2FICA 3DPQA 3B53X 1URUA 2F1BA 4NPHA 4R5JA 4E81A 3UITA 1MJGA 4R5IA 1SU8A 2ZXQA 4E3CA 5KBPA 4EZQA 3T47A 4EZNA 4M0MA 3BUDA 4AZCA 3RV0A 4FZOA 3DX3A 3BLBA
chains in the Genus database with same CATH topology
2JNSA 3DPPA 2GAFD 1GNTA 2YIVX 3F7WA 2ND1A 3I04A 3QA8A 4JWIA 2EWFA 4HYBA 1DKXA 4JWEA 3D2FA 4JWDA 4PO2A 3T4AG 4JWCA 4R5LA 4IWPA 4HR1A 1W9MA 3KDRA 4JNEA 3O3NB 3O3OB 1DKYA 3OWGA 2PY6A 4H6IA 4EZUA 2NCZA 3A98A 4R5GA 3ERCC 3T49A 4EZRA 3VKHA 3D2EA 4EZYA 4HR1B 4IWOA 2YI9A 4JLCA 4JNFA 4UDYX 4HY9A 1E1DA 4R5KA 2QFFA 2GA9D 3VEAA 3LMFA 4F01A 4IM2A 1JQKA 3RV1A 4EZXA 2KHOA 4UDXX 3DPOA 3QNJA 4JL9A 4JN4A 3GI7A 4KIKA 3I39X 1E9VA 4G6QA 3KAWA 1GNLA 2N3KA 1OA1A 3VEBA 4EZVA 3KAVA 1UPXA 2QXLA 4EZPA 1ZYLA 3ER9B 2WINM 2Z8YA 2ND0A 3T46A 4IM0A 2OBLA 4KIKB 1OA0A 4IM3A 3DPQA 3T48A 3ZEDA 2YIAA 5FIGA 3B53X 3O3MB 3B52X 4EZWA 4EZTA 4NPHA 4FM3A 4R5JA 5TKYA 4E81A 1U00A 5FLEX 4H6HA 3UITA 1MJGA 2OBMA 3I01A 5E84A 2LM0A 2YIBA 4EZZA 4R5IA 1DKZA 1SU6A 1SU8A 1SUFA 3OHXM 4E3CA 2RT6A 1GN9A 3C7NA 4IW0A 1OAOA 2YI8A 3B51X 4IWQA 4EZQA 3T47A 4EZNA 4M0MA 4B9QA 4D8JA 4EZOA 3ER8C 3FD9A 3L3OM 2EX3B 2X5CA 1E2UA 4EZSA 3RV0A 1SU7A 4F00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NCZ A;  2ND1 A;  2JNS A;  2ND0 A;  2N3K A; 
#chains in the Genus database with same CATH topology
 5C5B A;  3DPP A;  3F7W A;  1TQT A;  2V0O A;  4JWI A;  2EWF A;  1PS3 A;  4HYB A;  2D1L A;  1DKX A;  4JWD A;  3OK8 A;  3T4A G;  4IWP A;  2JNK A;  3O3N B;  3HAJ A;  3OWG A;  3Q84 A;  2C08 A;  3DX4 A;  3QE6 A;  4EZR A;  4HR1 B;  2F18 A;  4BNE A;  4DYL A;  4AKV A;  3CVR A;  3VEA A;  4IM2 A;  1ZWW A;  4ATM A;  1HTY A;  4KIK A;  4G6Q A;  4WPE A;  2N3K A;  1OA1 A;  1TQW A;  4EZV A;  2QXL A;  2Q12 A;  3G9G A;  2WIN M;  3BUP A;  2EFK A;  5FIG A;  3O3M B;  1O7D C;  1TQV A;  1I4T A;  5FLE X;  3LLL A;  3I01 A;  3BVU A;  3DDF A;  1TQU A;  3PLT A;  1X04 A;  2YL5 A;  2F7P A;  1LQ7 A;  2OZN B;  4D8J A;  1YWM A;  3ER8 C;  2ELB A;  4WPC A;  2EX3 B;  1E2U A;  4EZX A;  2OW6 A;  3CV5 A;  1I49 A;  4AZH A;  4DCN C;  3D52 A;  3QWE A;  2YIV X;  2ND1 A;  3I04 A;  4AZC B;  3D2F A;  5C5B B;  1Y2O A;  2YKT A;  2QKW A;  2RAJ A;  1W9M A;  3D4Y A;  4H6I A;  4EZU A;  2NCZ A;  3T49 A;  3DX1 A;  3VKH A;  2X3W A;  4UDY X;  2QFF A;  2GA9 D;  4F01 A;  3QNJ A;  2RAI A;  3GI7 A;  2GF4 A;  3L3P A;  3CZN A;  2Z8Y A;  4AZ7 A;  4IM0 A;  4KIK B;  3HAH A;  4FZP A;  3T48 A;  3ZED A;  2YIA A;  1X03 A;  2MI7 A;  3EJU A;  2D4C A;  2Q13 A;  3LVT A;  3CZS A;  3D4Z A;  4H6H A;  5E84 A;  2YIB A;  1R33 A;  3BUQ A;  3SOG A;  1GN9 A;  1WDZ A;  2YI8 A;  3B51 X;  3RPM A;  4IWQ A;  4NQI A;  4B9Q A;  3Q0K A;  3FD9 A;  2X5C A;  3EJT A;  3QNI A;  1SU7 A;  4I1Q A;  3EJS A;  2PMR A;  2JNS A;  2YLL A;  3DX0 A;  3BVV A;  3BUI A;  3QA8 A;  2X3X A;  3EJP A;  2OW7 A;  3ACO A;  4PO2 A;  4JWC A;  4R5L A;  4AVM A;  2F7Q A;  2YL8 A;  2Z0N A;  3EJQ A;  3A98 A;  4R5G A;  2Z0O A;  1QWU A;  4IWO A;  2YI9 A;  4JLC A;  1R34 A;  2ALW A;  3CKD A;  3DDG A;  4HY9 A;  1E1D A;  1O7D B;  4AZI A;  2OO2 A;  1QWN A;  2KHO A;  3DPO A;  4JL9 A;  1R5E A;  4AZ6 A;  1HWW A;  2YLA A;  4AZG A;  3VEB A;  2YL9 A;  2F1A A;  3ER9 B;  1OA0 A;  4IM3 A;  4AZ5 A;  3DYT A;  3D51 A;  3B52 X;  4EZW A;  4H8S A;  4EZT A;  4FM3 A;  2YL6 A;  5TKY A;  3M3W A;  3BUB A;  1U00 A;  2EFL A;  2FYV A;  2OBM A;  4EZZ A;  2LM0 A;  1DKZ A;  2O0I 1;  1SU6 A;  1SUF A;  3BVX A;  3D50 A;  3OHX M;  2WYI A;  2RT6 A;  3C7N A;  4IW0 A;  1OAO A;  4EZO A;  3EJR A;  2WYH A;  3L3O M;  3CAZ A;  2LXY A;  2RAK A;  4FZS A;  4EZS A;  1TQS A;  4F00 A;  2X3V A;  3BVT A;  2GAF D;  1GNT A;  3ABH A;  4JWE A;  4AZB A;  2F7R A;  3SYV A;  3BVW A;  4HR1 A;  1HXK A;  3KDR A;  4JNE A;  3O3O B;  1I4D A;  1DKY A;  2PY6 A;  3HAI A;  3ERC C;  3DX2 A;  3D2E A;  4EZY A;  3I2W A;  4JNF A;  4NSW A;  4R5K A;  3LMF A;  3RV1 A;  1JQK A;  4UDX X;  4JN4 A;  3I39 X;  1E9V A;  2F7O A;  3KAW A;  1QX1 A;  1GNL A;  1I4L A;  3KAV A;  1UPX A;  4EZP A;  1ZYL A;  2ND0 A;  2Z0V A;  3T46 A;  2OBL A;  2FIC A;  3DPQ A;  3B53 X;  1URU A;  2F1B A;  4NPH A;  4R5J A;  4E81 A;  3UIT A;  1MJG A;  4R5I A;  1SU8 A;  2ZXQ A;  4E3C A;  5KBP A;  4EZQ A;  3T47 A;  4EZN A;  4M0M A;  3BUD A;  4AZC A;  3RV0 A;  4FZO A;  3DX3 A;  3BLB A; 
#chains in the Genus database with same CATH homology
 2JNS A;  3DPP A;  2GAF D;  1GNT A;  2YIV X;  3F7W A;  2ND1 A;  3I04 A;  3QA8 A;  4JWI A;  2EWF A;  4HYB A;  1DKX A;  4JWE A;  3D2F A;  4JWD A;  4PO2 A;  3T4A G;  4JWC A;  4R5L A;  4IWP A;  4HR1 A;  1W9M A;  3KDR A;  4JNE A;  3O3N B;  3O3O B;  1DKY A;  3OWG A;  2PY6 A;  4H6I A;  4EZU A;  2NCZ A;  3A98 A;  4R5G A;  3ERC C;  3T49 A;  4EZR A;  3VKH A;  3D2E A;  4EZY A;  4HR1 B;  4IWO A;  2YI9 A;  4JLC A;  4JNF A;  4UDY X;  4HY9 A;  1E1D A;  4R5K A;  2QFF A;  2GA9 D;  3VEA A;  3LMF A;  4F01 A;  4IM2 A;  1JQK A;  3RV1 A;  4EZX A;  2KHO A;  4UDX X;  3DPO A;  3QNJ A;  4JL9 A;  4JN4 A;  3GI7 A;  4KIK A;  3I39 X;  1E9V A;  4G6Q A;  3KAW A;  1GNL A;  2N3K A;  1OA1 A;  3VEB A;  4EZV A;  3KAV A;  1UPX A;  2QXL A;  4EZP A;  1ZYL A;  3ER9 B;  2WIN M;  2Z8Y A;  2ND0 A;  3T46 A;  4IM0 A;  2OBL A;  4KIK B;  1OA0 A;  4IM3 A;  3DPQ A;  3T48 A;  3ZED A;  2YIA A;  5FIG A;  3B53 X;  3O3M B;  3B52 X;  4EZW A;  4EZT A;  4NPH A;  4FM3 A;  4R5J A;  5TKY A;  4E81 A;  1U00 A;  5FLE X;  4H6H A;  3UIT A;  1MJG A;  2OBM A;  3I01 A;  5E84 A;  2LM0 A;  2YIB A;  4EZZ A;  4R5I A;  1DKZ A;  1SU6 A;  1SU8 A;  1SUF A;  3OHX M;  4E3C A;  2RT6 A;  1GN9 A;  3C7N A;  4IW0 A;  1OAO A;  2YI8 A;  3B51 X;  4IWQ A;  4EZQ A;  3T47 A;  4EZN A;  4M0M A;  4B9Q A;  4D8J A;  4EZO A;  3ER8 C;  3FD9 A;  3L3O M;  2EX3 B;  2X5C A;  1E2U A;  4EZS A;  3RV0 A;  1SU7 A;  4F00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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