2ND1 | Genus

Total Genus 25

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	25
sequence length	83
structure length	83
Chain Sequence	SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transcription/transferase
source organism	Homo sapiens
publication title	Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. pubmed doi rcsb
molecule keywords	Bromodomain-containing protein 4
total genus	25
structure length	83
sequence length	83
ec nomenclature
pdb deposition date	2016-04-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF17035	BET	Bromodomain extra-terminal - transcription regulation

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1270.220	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak; Chain:A; Domain 2	Substrate Binding Domain Of Dnak; Chain:A; Domain 2	2nd1A01

2NCZA 2ND0A 2ND1A 2JNSA 2N3KA
chains in the Genus database with same CATH superfamily

4M0MA 2LXYA 2ELBA 2EFLA 2X3WA 1QWNA 1R33A 4IWOA 2Z0OA 1QWUA 1DKXA 4R5GA 4AZCB 3B52X 2YL5A 4HY9A 3HAHA 4KIKB 4EZXA 1OA1A 4BNEA 3T49A 1GNLA 4IM0A 4E81A 1E2UA 3FD9A 3B53X 3BLBA 5KBPA 1QX1A 2JNKA 3OHXM 3DPOA 4NPHA 3C7NA 3DPQA 3BVTA 3VEAA 2Z0VA 3G9GA 3DX1A 5E84A 3O3OB 3DDFA 4IM2A 3GI7A 3B51X 3CKDA 2ND1A 3ERCC 4HR1A 4AZ5A 3T46A 2F7RA 4JNFA 3T4AG 3LLLA 1HWWA 4AZHA 4AZ6A 3LMFA 2RAJA 3BVXA 3CVRA 3DX3A 3D50A 4IM3A 3ER9B 1O7DC 2F7OA 4ATMA 4NQIA 2YL9A 3RV1A 1DKYA 2F1AA 1GNTA 2YLLA 3UITA 4EZWA 4DYLA 4AZ7A 4UDYX 3Q0KA 1X03A 3EJSA 4JLCA 1OAOA 1I4LA 2EX3B 2YI8A 2PMRA 1SU8A 1MJGA 3M3WA 3KAVA 4FZSA 3EJRA 1I49A 1R5EA 1YWMA 3D2FA 2OBLA 2QKWA 1Y2OA 3D51A 4EZYA 2Q12A 2YL8A 1E1DA 3T48A 3RPMA 1W9MA 1OA0A 4HR1B 3QE6A 3EJQA 2Z0NA 3VKHA 1UPXA 4PO2A 3SOGA 3OK8A 2FYVA 3I39X 2ZXQA 1E9VA 2Q13A 2LM0A 4EZVA 1WDZA 4R5JA 4NSWA 2OW7A 3BUDA 2F1BA 2WINM 2ND0A 4IW0A 2GF4A 4EZSA 3PLTA 4R5IA 3CZSA 4IWPA 3HAIA 4DCNC 4JNEA 4H8SA 3KDRA 3DDGA 2YL6A 4JN4A 1TQVA 3D4YA 4JWIA 2OO2A 4EZQA 2YIAA 3F7WA 3CAZA 4WPCA 3L3OM 4H6IA 1ZYLA 4B9QA 3ABHA 4H6HA 2EFKA 1R34A 3DYTA 4HYBA 1SUFA 3CV5A 2F7QA 4EZZA 2YKTA 1GN9A 3ZEDA 2ALWA 2GA9D 1I4DA 2Z8YA 5FIGA 3VEBA 2KHOA 3SYVA 4JWCA 4R5KA 3DX4A 3BUBA 3D4ZA 2OW6A 1HTYA 3I04A 2YLAA 4EZTA 4AZIA 3DX0A 3L3PA 4JL9A 4F01A 4D8JA 2X5CA 2RAKA 3BVVA 3QA8A 4JWEA 4AVMA 4I1QA 3BUPA 1PS3A 2QFFA 5C5BB 1HXKA 4WPEA 2O0I1 2RAIA 4IWQA 3T47A 1O7DB 2YIVX 3D52A 3QNJA 4AZBA 2YI9A 2EWFA 5FLEX 1TQTA 3I2WA 2WYIA 3A98A 3CZNA 2OZNB 3DX2A 4EZUA 1I4TA 3RV0A 2X3VA 2WYHA 3QWEA 4AZGA 3DPPA 2V0OA 3BVUA 1JQKA 3O3NB 3ACOA 2C08A 4EZOA 1U00A 2FICA 4FZPA 3D2EA 4G6QA 3O3MB 5C5BA 3I01A 1TQWA 2OBMA 3LVTA 3QNIA 2PY6A 4FZOA 3KAWA 4AKVA 4AZCA 4F00A 1TQSA 1X04A 3BUQA 2JNSA 2MI7A 4KIKA 1ZWWA 4UDXX 1URUA 3EJTA 2GAFD 3ER8C 2X3XA 3EJUA 3HAJA 4EZPA 2N3KA 3BUIA 2QXLA 1TQUA 4JWDA 4FM3A 1LQ7A 3Q84A 4EZRA 3BVWA 3OWGA 2F7PA 5TKYA 2RT6A 4R5LA 2NCZA 1DKZA 3EJPA 1SU6A 2YIBA 2D1LA 1SU7A 2F18A 4EZNA 4E3CA 2D4CA
chains in the Genus database with same CATH topology

2YI9A 4M0MA 2EWFA 5FLEX 4EZWA 4JN4A 4UDYX 3A98A 4JWIA 4EZUA 4IWOA 3RV0A 4JLCA 1OAOA 3DPPA 4EZQA 1DKXA 2EX3B 2YIAA 1JQKA 3F7WA 4R5GA 2YI8A 3O3NB 3L3OM 4H6IA 1MJGA 1ZYLA 1SU8A 3B52X 4B9QA 4HY9A 3KAVA 4EZOA 4KIKB 4H6HA 1U00A 4G6QA 3D2EA 4EZXA 3O3MB 1OA1A 4HYBA 1SUFA 3I01A 3T49A 2OBMA 2PY6A 1GNLA 3KAWA 4EZZA 1GN9A 3ZEDA 3D2FA 2OBLA 2GA9D 4EZYA 4IM0A 4E81A 1E1DA 2Z8YA 5FIGA 3T48A 1W9MA 1OA0A 1E2UA 4HR1B 4F00A 3FD9A 3B53X 3VEBA 2KHOA 3VKHA 1UPXA 2JNSA 4JWCA 4KIKA 4PO2A 4R5KA 4UDXX 3OHXM 3DPOA 4NPHA 2GAFD 3I04A 3ER8C 3C7NA 3DPQA 4EZTA 3VEAA 3I39X 4EZPA 1E9VA 5E84A 3O3OB 2N3KA 4IM2A 2LM0A 3GI7A 3B51X 4EZVA 4JL9A 4F01A 4R5JA 2ND1A 4D8JA 2QXLA 3ERCC 2X5CA 4HR1A 3T46A 3QA8A 4JWDA 4JNFA 4JWEA 2WINM 3T4AG 2ND0A 4FM3A 4IW0A 3LMFA 4EZRA 4EZSA 3OWGA 2QFFA 5TKYA 2RT6A 4R5IA 4R5LA 4IM3A 3ER9B 2NCZA 1DKZA 4IWQA 3T47A 4IWPA 2YIVX 1SU6A 2YIBA 3RV1A 3QNJA 1DKYA 4JNEA 1GNTA 1SU7A 4EZNA 4E3CA 3KDRA 3UITA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 2NCZ A;  2ND0 A;  2ND1 A;  2JNS A;  2N3K A; 
#chains in the Genus database with same CATH topology
 4M0M A;  2LXY A;  2ELB A;  2EFL A;  2X3W A;  1QWN A;  1R33 A;  4IWO A;  2Z0O A;  1QWU A;  1DKX A;  4R5G A;  4AZC B;  3B52 X;  2YL5 A;  4HY9 A;  3HAH A;  4KIK B;  4EZX A;  1OA1 A;  4BNE A;  3T49 A;  1GNL A;  4IM0 A;  4E81 A;  1E2U A;  3FD9 A;  3B53 X;  3BLB A;  5KBP A;  1QX1 A;  2JNK A;  3OHX M;  3DPO A;  4NPH A;  3C7N A;  3DPQ A;  3BVT A;  3VEA A;  2Z0V A;  3G9G A;  3DX1 A;  5E84 A;  3O3O B;  3DDF A;  4IM2 A;  3GI7 A;  3B51 X;  3CKD A;  2ND1 A;  3ERC C;  4HR1 A;  4AZ5 A;  3T46 A;  2F7R A;  4JNF A;  3T4A G;  3LLL A;  1HWW A;  4AZH A;  4AZ6 A;  3LMF A;  2RAJ A;  3BVX A;  3CVR A;  3DX3 A;  3D50 A;  4IM3 A;  3ER9 B;  1O7D C;  2F7O A;  4ATM A;  4NQI A;  2YL9 A;  3RV1 A;  1DKY A;  2F1A A;  1GNT A;  2YLL A;  3UIT A;  4EZW A;  4DYL A;  4AZ7 A;  4UDY X;  3Q0K A;  1X03 A;  3EJS A;  4JLC A;  1OAO A;  1I4L A;  2EX3 B;  2YI8 A;  2PMR A;  1SU8 A;  1MJG A;  3M3W A;  3KAV A;  4FZS A;  3EJR A;  1I49 A;  1R5E A;  1YWM A;  3D2F A;  2OBL A;  2QKW A;  1Y2O A;  3D51 A;  4EZY A;  2Q12 A;  2YL8 A;  1E1D A;  3T48 A;  3RPM A;  1W9M A;  1OA0 A;  4HR1 B;  3QE6 A;  3EJQ A;  2Z0N A;  3VKH A;  1UPX A;  4PO2 A;  3SOG A;  3OK8 A;  2FYV A;  3I39 X;  2ZXQ A;  1E9V A;  2Q13 A;  2LM0 A;  4EZV A;  1WDZ A;  4R5J A;  4NSW A;  2OW7 A;  3BUD A;  2F1B A;  2WIN M;  2ND0 A;  4IW0 A;  2GF4 A;  4EZS A;  3PLT A;  4R5I A;  3CZS A;  4IWP A;  3HAI A;  4DCN C;  4JNE A;  4H8S A;  3KDR A;  3DDG A;  2YL6 A;  4JN4 A;  1TQV A;  3D4Y A;  4JWI A;  2OO2 A;  4EZQ A;  2YIA A;  3F7W A;  3CAZ A;  4WPC A;  3L3O M;  4H6I A;  1ZYL A;  4B9Q A;  3ABH A;  4H6H A;  2EFK A;  1R34 A;  3DYT A;  4HYB A;  1SUF A;  3CV5 A;  2F7Q A;  4EZZ A;  2YKT A;  1GN9 A;  3ZED A;  2ALW A;  2GA9 D;  1I4D A;  2Z8Y A;  5FIG A;  3VEB A;  2KHO A;  3SYV A;  4JWC A;  4R5K A;  3DX4 A;  3BUB A;  3D4Z A;  2OW6 A;  1HTY A;  3I04 A;  2YLA A;  4EZT A;  4AZI A;  3DX0 A;  3L3P A;  4JL9 A;  4F01 A;  4D8J A;  2X5C A;  2RAK A;  3BVV A;  3QA8 A;  4JWE A;  4AVM A;  4I1Q A;  3BUP A;  1PS3 A;  2QFF A;  5C5B B;  1HXK A;  4WPE A;  2O0I 1;  2RAI A;  4IWQ A;  3T47 A;  1O7D B;  2YIV X;  3D52 A;  3QNJ A;  4AZB A;  2YI9 A;  2EWF A;  5FLE X;  1TQT A;  3I2W A;  2WYI A;  3A98 A;  3CZN A;  2OZN B;  3DX2 A;  4EZU A;  1I4T A;  3RV0 A;  2X3V A;  2WYH A;  3QWE A;  4AZG A;  3DPP A;  2V0O A;  3BVU A;  1JQK A;  3O3N B;  3ACO A;  2C08 A;  4EZO A;  1U00 A;  2FIC A;  4FZP A;  3D2E A;  4G6Q A;  3O3M B;  5C5B A;  3I01 A;  1TQW A;  2OBM A;  3LVT A;  3QNI A;  2PY6 A;  4FZO A;  3KAW A;  4AKV A;  4AZC A;  4F00 A;  1TQS A;  1X04 A;  3BUQ A;  2JNS A;  2MI7 A;  4KIK A;  1ZWW A;  4UDX X;  1URU A;  3EJT A;  2GAF D;  3ER8 C;  2X3X A;  3EJU A;  3HAJ A;  4EZP A;  2N3K A;  3BUI A;  2QXL A;  1TQU A;  4JWD A;  4FM3 A;  1LQ7 A;  3Q84 A;  4EZR A;  3BVW A;  3OWG A;  2F7P A;  5TKY A;  2RT6 A;  4R5L A;  2NCZ A;  1DKZ A;  3EJP A;  1SU6 A;  2YIB A;  2D1L A;  1SU7 A;  2F18 A;  4EZN A;  4E3C A;  2D4C A; 
#chains in the Genus database with same CATH homology
 2YI9 A;  4M0M A;  2EWF A;  5FLE X;  4EZW A;  4JN4 A;  4UDY X;  3A98 A;  4JWI A;  4EZU A;  4IWO A;  3RV0 A;  4JLC A;  1OAO A;  3DPP A;  4EZQ A;  1DKX A;  2EX3 B;  2YIA A;  1JQK A;  3F7W A;  4R5G A;  2YI8 A;  3O3N B;  3L3O M;  4H6I A;  1MJG A;  1ZYL A;  1SU8 A;  3B52 X;  4B9Q A;  4HY9 A;  3KAV A;  4EZO A;  4KIK B;  4H6H A;  1U00 A;  4G6Q A;  3D2E A;  4EZX A;  3O3M B;  1OA1 A;  4HYB A;  1SUF A;  3I01 A;  3T49 A;  2OBM A;  2PY6 A;  1GNL A;  3KAW A;  4EZZ A;  1GN9 A;  3ZED A;  3D2F A;  2OBL A;  2GA9 D;  4EZY A;  4IM0 A;  4E81 A;  1E1D A;  2Z8Y A;  5FIG A;  3T48 A;  1W9M A;  1OA0 A;  1E2U A;  4HR1 B;  4F00 A;  3FD9 A;  3B53 X;  3VEB A;  2KHO A;  3VKH A;  1UPX A;  2JNS A;  4JWC A;  4KIK A;  4PO2 A;  4R5K A;  4UDX X;  3OHX M;  3DPO A;  4NPH A;  2GAF D;  3I04 A;  3ER8 C;  3C7N A;  3DPQ A;  4EZT A;  3VEA A;  3I39 X;  4EZP A;  1E9V A;  5E84 A;  3O3O B;  2N3K A;  4IM2 A;  2LM0 A;  3GI7 A;  3B51 X;  4EZV A;  4JL9 A;  4F01 A;  4R5J A;  2ND1 A;  4D8J A;  2QXL A;  3ERC C;  2X5C A;  4HR1 A;  3T46 A;  3QA8 A;  4JWD A;  4JNF A;  4JWE A;  2WIN M;  3T4A G;  2ND0 A;  4FM3 A;  4IW0 A;  3LMF A;  4EZR A;  4EZS A;  3OWG A;  2QFF A;  5TKY A;  2RT6 A;  4R5I A;  4R5L A;  4IM3 A;  3ER9 B;  2NCZ A;  1DKZ A;  4IWQ A;  3T47 A;  4IWP A;  2YIV X;  1SU6 A;  2YIB A;  3RV1 A;  3QNJ A;  1DKY A;  4JNE A;  1GNT A;  1SU7 A;  4EZN A;  4E3C A;  3KDR A;  3UIT A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2ND1A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations