2Q12A

Crystal structure of bar domain of appl1
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
247
structure length
242
Chain Sequence
LEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
pubmed doi rcsb
molecule tags Protein transport
source organism Homo sapiens
molecule keywords DCC-interacting protein 13 alpha
total genus 99
structure length 242
sequence length 247
ec nomenclature
pdb deposition date 2007-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16746 BAR_3 BAR domain of APPL family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2q12A00
1ZWWA 2Z0NA 3G9GA 4DCNC 3HAJA 4AKVA 1X03A 3I2WA 3Q0KA 1I4DA 2EFLA 3LLLA 3QE6A 3PLTA 1Y2OA 4FZSA 3OK8A 4NQIA 4ATMA 3ABHA 4NSWA 3QNIA 2D1LA 4WPEA 2FICA 2X3VA 4I1QA 3SYVA 2D4CA 4BNEA 2Q12A 2Z0VA 4AVMA 1URUA 3Q84A 2X3WA 1WDZA 2X3XA 2EFKA 5C5BA 2RAJA 2YKTA 3ACOA 3DYTA 3M3WA 2Q13A 1I4TA 2RAIA 3HAIA 5C5BB 3CAZA 2RAKA 4WPCA 4DYLA 1I4LA 1I49A 2ELBA 3QWEA 2V0OA 2C08A 4H8SA 3SOGA 2Z0OA 1X04A 3HAHA
chains in the Genus database with same CATH superfamily
4EZTA 3DPPA 3T4AG 4AZCB 4JL9A 3FD9A 4AVMA 1OA0A 1W9MA 2RAKA 4H6HA 3BVTA 3HAJA 5FLEX 3BUIA 3I39X 4EZWA 4ATMA 1TQWA 3GI7A 2OW6A 2F7RA 2YL8A 3D50A 2ND0A 4EZQA 4HYBA 5C5BB 1QWUA 3RV1A 3DX0A 3QWEA 3QNIA 2ZXQA 3D2EA 3QE6A 3PLTA 3BUQA 3ABHA 4AZ7A 3EJSA 3CV5A 2YIAA 3ER9B 1JQKA 3M3WA 4DYLA 1HXKA 1R33A 1SUFA 4UDXX 1DKYA 4M0MA 3DX2A 3EJUA 4JWEA 2YLAA 2PY6A 1GNLA 1E9VA 3D51A 4EZXA 1TQUA 4JNEA 1R34A 3BVXA 2YL6A 3DX4A 3Q0KA 4JWCA 3CZSA 4D8JA 2D1LA 2Q12A 1DKZA 3OWGA 1TQSA 2F1BA 3CAZA 1I4LA 1I49A 3DDGA 1ZWWA 3EJTA 3B53X 3G9GA 3D4YA 2F1AA 4IM3A 3D52A 4F01A 1OA1A 3KAVA 1Y2OA 2YL9A 4EZOA 3I01A 4AZGA 3B52X 1E2UA 1GNTA 2X3WA 3CKDA 3BUDA 3ZEDA 4EZPA 2OBMA 2EFKA 1U00A 2YIBA 2N3KA 3B51X 1UPXA 2LXYA 1SU7A 3DPOA 2KHOA 4IW0A 1ZYLA 3VEBA 2OBLA 2X3VA 4BNEA 2WINM 3VEAA 2X3XA 4R5LA 4R5KA 3OHXM 2Z8YA 2WYIA 4E3CA 3BLBA 1QX1A 4UDYX 2QFFA 2JNSA 3OK8A 4EZUA 3T47A 3ERCC 3SYVA 1QWNA 3Q84A 1R5EA 1WDZA 4FZPA 1HTYA 3HAIA 4EZYA 4JNFA 3BVUA 2Z0OA 5FIGA 3HAHA 2F7OA 3LVTA 4JWIA 4R5IA 2O0I1 1GN9A 4IWQA 3EJPA 4NPHA 4R5JA 3RPMA 4EZVA 3D2FA 3O3OB 2LM0A 2NCZA 2ALWA 2F18A 3I04A 2EFLA 3LLLA 4AZBA 3CVRA 4FZSA 4G6QA 4WPEA 3BVWA 1PS3A 4B9QA 1O7DB 3L3PA 2RAIA 4HR1A 3CZNA 4H6IA 4EZSA 2OW7A 1YWMA 3LMFA 1X03A 5TKYA 2FICA 1URUA 3ACOA 3C7NA 1I4TA 3T48A 4IWOA 3EJQA 2GF4A 4HY9A 1HWWA 2YIVX 2Z0NA 4AZIA 4IWPA 4AZHA 4EZZA 4FM3A 1MJGA 4NSWA 4JWDA 2YI8A 2JNKA 4EZRA 3DDFA 4PO2A 2QXLA 2MI7A 4AZ5A 3VKHA 2C08A 1OAOA 2GAFD 2YI9A 1E1DA 4JLCA 1LQ7A 3T49A 3O3MB 2YL5A 4R5GA 4KIKB 4FZOA 4EZNA 3F7WA 2Q13A 4JN4A 3KDRA 4WPCA 3ER8C 4H8SA 4HR1B 2OZNB 3EJRA 1O7DC 4AZCA 4AKVA 3I2WA 2EX3B 5E84A 3DX1A 1SU8A 2X5CA 2F7PA 1TQVA 1DKXA 3T46A 2GA9D 2EWFA 2V0OA 2FYVA 4E81A 3SOGA 1SU6A 4DCNC 2PMRA 1I4DA 3DPQA 4NQIA 3QNJA 3A98A 4KIKA 4I1QA 2D4CA 2ND1A 2QKWA 3BUPA 5C5BA 2RAJA 2OO2A 2YKTA 3O3NB 3DYTA 1TQTA 3BUBA 3QA8A 3KAWA 2YLLA 1X04A 2F7QA 3RV0A 2RT6A 4AZ6A 4F00A 2WYHA 3UITA 4IM0A 5KBPA 2Z0VA 3DX3A 3D4ZA 3L3OM 3BVVA 2ELBA 4IM2A
chains in the Genus database with same CATH topology
1ZWWA 2Z0NA 3G9GA 4DCNC 3HAJA 4AKVA 1X03A 3I2WA 3Q0KA 1I4DA 2EFLA 3LLLA 3QE6A 3PLTA 1Y2OA 4FZSA 3OK8A 4NQIA 4ATMA 3ABHA 4NSWA 3QNIA 2D1LA 4WPEA 2FICA 2X3VA 4I1QA 3SYVA 2D4CA 4BNEA 2Q12A 2Z0VA 4AVMA 1URUA 3Q84A 2X3WA 1WDZA 2X3XA 2EFKA 5C5BA 2RAJA 2YKTA 3ACOA 3DYTA 3M3WA 2Q13A 1I4TA 2RAIA 3HAIA 5C5BB 3CAZA 2RAKA 4WPCA 4DYLA 1I4LA 1I49A 2ELBA 3QWEA 2V0OA 2C08A 4H8SA 3SOGA 2Z0OA 1X04A 3HAHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZWW A;  2Z0N A;  3G9G A;  4DCN C;  3HAJ A;  4AKV A;  1X03 A;  3I2W A;  3Q0K A;  1I4D A;  2EFL A;  3LLL A;  3QE6 A;  3PLT A;  1Y2O A;  4FZS A;  3OK8 A;  4NQI A;  4ATM A;  3ABH A;  4NSW A;  3QNI A;  2D1L A;  4WPE A;  2FIC A;  2X3V A;  4I1Q A;  3SYV A;  2D4C A;  4BNE A;  2Q12 A;  2Z0V A;  4AVM A;  1URU A;  3Q84 A;  2X3W A;  1WDZ A;  2X3X A;  2EFK A;  5C5B A;  2RAJ A;  2YKT A;  3ACO A;  3DYT A;  3M3W A;  2Q13 A;  1I4T A;  2RAI A;  3HAI A;  5C5B B;  3CAZ A;  2RAK A;  4WPC A;  4DYL A;  1I4L A;  1I49 A;  2ELB A;  3QWE A;  2V0O A;  2C08 A;  4H8S A;  3SOG A;  2Z0O A;  1X04 A;  3HAH A; 
#chains in the Genus database with same CATH topology
 4EZT A;  3DPP A;  3T4A G;  4AZC B;  4JL9 A;  3FD9 A;  4AVM A;  1OA0 A;  1W9M A;  2RAK A;  4H6H A;  3BVT A;  3HAJ A;  5FLE X;  3BUI A;  3I39 X;  4EZW A;  4ATM A;  1TQW A;  3GI7 A;  2OW6 A;  2F7R A;  2YL8 A;  3D50 A;  2ND0 A;  4EZQ A;  4HYB A;  5C5B B;  1QWU A;  3RV1 A;  3DX0 A;  3QWE A;  3QNI A;  2ZXQ A;  3D2E A;  3QE6 A;  3PLT A;  3BUQ A;  3ABH A;  4AZ7 A;  3EJS A;  3CV5 A;  2YIA A;  3ER9 B;  1JQK A;  3M3W A;  4DYL A;  1HXK A;  1R33 A;  1SUF A;  4UDX X;  1DKY A;  4M0M A;  3DX2 A;  3EJU A;  4JWE A;  2YLA A;  2PY6 A;  1GNL A;  1E9V A;  3D51 A;  4EZX A;  1TQU A;  4JNE A;  1R34 A;  3BVX A;  2YL6 A;  3DX4 A;  3Q0K A;  4JWC A;  3CZS A;  4D8J A;  2D1L A;  2Q12 A;  1DKZ A;  3OWG A;  1TQS A;  2F1B A;  3CAZ A;  1I4L A;  1I49 A;  3DDG A;  1ZWW A;  3EJT A;  3B53 X;  3G9G A;  3D4Y A;  2F1A A;  4IM3 A;  3D52 A;  4F01 A;  1OA1 A;  3KAV A;  1Y2O A;  2YL9 A;  4EZO A;  3I01 A;  4AZG A;  3B52 X;  1E2U A;  1GNT A;  2X3W A;  3CKD A;  3BUD A;  3ZED A;  4EZP A;  2OBM A;  2EFK A;  1U00 A;  2YIB A;  2N3K A;  3B51 X;  1UPX A;  2LXY A;  1SU7 A;  3DPO A;  2KHO A;  4IW0 A;  1ZYL A;  3VEB A;  2OBL A;  2X3V A;  4BNE A;  2WIN M;  3VEA A;  2X3X A;  4R5L A;  4R5K A;  3OHX M;  2Z8Y A;  2WYI A;  4E3C A;  3BLB A;  1QX1 A;  4UDY X;  2QFF A;  2JNS A;  3OK8 A;  4EZU A;  3T47 A;  3ERC C;  3SYV A;  1QWN A;  3Q84 A;  1R5E A;  1WDZ A;  4FZP A;  1HTY A;  3HAI A;  4EZY A;  4JNF A;  3BVU A;  2Z0O A;  5FIG A;  3HAH A;  2F7O A;  3LVT A;  4JWI A;  4R5I A;  2O0I 1;  1GN9 A;  4IWQ A;  3EJP A;  4NPH A;  4R5J A;  3RPM A;  4EZV A;  3D2F A;  3O3O B;  2LM0 A;  2NCZ A;  2ALW A;  2F18 A;  3I04 A;  2EFL A;  3LLL A;  4AZB A;  3CVR A;  4FZS A;  4G6Q A;  4WPE A;  3BVW A;  1PS3 A;  4B9Q A;  1O7D B;  3L3P A;  2RAI A;  4HR1 A;  3CZN A;  4H6I A;  4EZS A;  2OW7 A;  1YWM A;  3LMF A;  1X03 A;  5TKY A;  2FIC A;  1URU A;  3ACO A;  3C7N A;  1I4T A;  3T48 A;  4IWO A;  3EJQ A;  2GF4 A;  4HY9 A;  1HWW A;  2YIV X;  2Z0N A;  4AZI A;  4IWP A;  4AZH A;  4EZZ A;  4FM3 A;  1MJG A;  4NSW A;  4JWD A;  2YI8 A;  2JNK A;  4EZR A;  3DDF A;  4PO2 A;  2QXL A;  2MI7 A;  4AZ5 A;  3VKH A;  2C08 A;  1OAO A;  2GAF D;  2YI9 A;  1E1D A;  4JLC A;  1LQ7 A;  3T49 A;  3O3M B;  2YL5 A;  4R5G A;  4KIK B;  4FZO A;  4EZN A;  3F7W A;  2Q13 A;  4JN4 A;  3KDR A;  4WPC A;  3ER8 C;  4H8S A;  4HR1 B;  2OZN B;  3EJR A;  1O7D C;  4AZC A;  4AKV A;  3I2W A;  2EX3 B;  5E84 A;  3DX1 A;  1SU8 A;  2X5C A;  2F7P A;  1TQV A;  1DKX A;  3T46 A;  2GA9 D;  2EWF A;  2V0O A;  2FYV A;  4E81 A;  3SOG A;  1SU6 A;  4DCN C;  2PMR A;  1I4D A;  3DPQ A;  4NQI A;  3QNJ A;  3A98 A;  4KIK A;  4I1Q A;  2D4C A;  2ND1 A;  2QKW A;  3BUP A;  5C5B A;  2RAJ A;  2OO2 A;  2YKT A;  3O3N B;  3DYT A;  1TQT A;  3BUB A;  3QA8 A;  3KAW A;  2YLL A;  1X04 A;  2F7Q A;  3RV0 A;  2RT6 A;  4AZ6 A;  4F00 A;  2WYH A;  3UIT A;  4IM0 A;  5KBP A;  2Z0V A;  3DX3 A;  3D4Z A;  3L3O M;  3BVV A;  2ELB A;  4IM2 A; 
#chains in the Genus database with same CATH homology
 1ZWW A;  2Z0N A;  3G9G A;  4DCN C;  3HAJ A;  4AKV A;  1X03 A;  3I2W A;  3Q0K A;  1I4D A;  2EFL A;  3LLL A;  3QE6 A;  3PLT A;  1Y2O A;  4FZS A;  3OK8 A;  4NQI A;  4ATM A;  3ABH A;  4NSW A;  3QNI A;  2D1L A;  4WPE A;  2FIC A;  2X3V A;  4I1Q A;  3SYV A;  2D4C A;  4BNE A;  2Q12 A;  2Z0V A;  4AVM A;  1URU A;  3Q84 A;  2X3W A;  1WDZ A;  2X3X A;  2EFK A;  5C5B A;  2RAJ A;  2YKT A;  3ACO A;  3DYT A;  3M3W A;  2Q13 A;  1I4T A;  2RAI A;  3HAI A;  5C5B B;  3CAZ A;  2RAK A;  4WPC A;  4DYL A;  1I4L A;  1I49 A;  2ELB A;  3QWE A;  2V0O A;  2C08 A;  4H8S A;  3SOG A;  2Z0O A;  1X04 A;  3HAH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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