2Q12A

Crystal structure of bar domain of appl1
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
247
structure length
242
Chain Sequence
LEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
pubmed doi rcsb
molecule tags Protein transport
source organism Homo sapiens
molecule keywords DCC-interacting protein 13 alpha
total genus 99
structure length 242
sequence length 247
ec nomenclature
pdb deposition date 2007-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16746 BAR_3 BAR domain of APPL family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2q12A00
3I2WA 3HAJA 2RAJA 1WDZA 1URUA 4WPCA 3CAZA 3PLTA 3DYTA 2Q13A 4FZSA 4I1QA 4AKVA 2C08A 4H8SA 2FICA 1ZWWA 2EFKA 1X04A 1Y2OA 4DCNC 3ABHA 4WPEA 5C5BA 3QE6A 3Q0KA 1X03A 2RAKA 3ACOA 3HAIA 2ELBA 2Z0OA 2Q12A 2RAIA 1I49A 3QWEA 4NSWA 1I4DA 2Z0NA 4AVMA 3LLLA 3M3WA 4ATMA 3G9GA 5C5BB 3OK8A 2D4CA 3QNIA 4NQIA 3SOGA 2X3XA 2D1LA 2V0OA 2EFLA 3Q84A 3HAHA 1I4LA 2X3VA 2X3WA 3SYVA 4BNEA 1I4TA 2YKTA 2Z0VA 4DYLA
chains in the Genus database with same CATH superfamily
2YI8A 3CAZA 3PLTA 4I1QA 3CKDA 1SUFA 3EJQA 4DCNC 2MI7A 1GNLA 3DX4A 3HAIA 2WINM 2OBLA 3BUIA 4JN4A 3ERCC 1E1DA 3O3NB 1HXKA 3VKHA 4IW0A 3RV0A 4DYLA 3D50A 3T48A 1R34A 3RPMA 3D4ZA 3VEAA 4FM3A 2OW6A 1TQTA 4R5JA 3EJTA 3QWEA 4IM3A 4AZ5A 2D4CA 4EZSA 2F1BA 2EFLA 4JWEA 1W9MA 4F01A 3CZNA 1QX1A 2QFFA 2Q13A 4JNEA 1GNTA 4EZZA 2Z0OA 4R5GA 2YI9A 3EJUA 2WYIA 3LLLA 3LVTA 1O7DC 3UITA 4AZIA 1I4LA 5E84A 4EZQA 2PY6A 1TQUA 2O0I1 3O3MB 2N3KA 3Q0KA 2JNKA 2LM0A 2FYVA 3LMFA 3RV1A 3EJRA 3FD9A 2JNSA 3M3WA 1DKYA 4UDXX 1YWMA 3Q84A 4E81A 2KHOA 4JL9A 3BUBA 3ACOA 2ND1A 4HY9A 4NSWA 4AZ7A 3L3PA 5TKYA 4JWCA 4AZBA 2GA9D 3DDGA 2WYHA 2YL8A 2YLLA 4H8SA 1X04A 4FZPA 4HR1A 2X5CA 1JQKA 4EZNA 2Q12A 4JLCA 3CZSA 1SU6A 1HWWA 3DPPA 3F7WA 4EZTA 1I4DA 3CV5A 4IWQA 2D1LA 4HR1B 3I01A 4NPHA 3BVVA 3DPQA 1O7DB 4EZOA 2YL5A 3I04A 3D4YA 4H6HA 1MJGA 4AVMA 2YL9A 3G9GA 1SU7A 4NQIA 5FIGA 2X3VA 3T49A 4EZRA 1DKZA 4AZCB 3I2WA 2F7PA 2FICA 2EFKA 2RAKA 3CVRA 1I49A 2EWFA 4EZXA 3BUQA 4EZUA 3SYVA 3D2FA 2Z0VA 3DX0A 4PO2A 1OA1A 2YL6A 2YIVX 2NCZA 1X03A 4KIKA 1SU8A 4JNFA 4JWIA 2ND0A 4IM2A 5C5BB 1HTYA 2F18A 4KIKB 3D52A 3L3OM 3OHXM 3KDRA 3ER8C 3DX1A 3QE6A 1R33A 4F00A 1E2UA 2LXYA 1U00A 4HYBA 3QA8A 2RAJA 1PS3A 1OA0A 3DPOA 1E9VA 1OAOA 4R5IA 2Z8YA 1ZYLA 2OBMA 4EZPA 3EJSA 2X3XA 3VEBA 2X3WA 3T47A 3I39X 3DX3A 2QXLA 3KAVA 1DKXA 2C08A 3DDFA 4E3CA 1ZWWA 2YIBA 1GN9A 4AZ6A 4IWPA 4AZCA 3SOGA 3BUDA 3B52X 4R5KA 2YKTA 3QNJA 4AZHA 4AZGA 1TQSA 3DX2A 3B51X 4D8JA 2OO2A 2RAIA 4H6IA 3BUPA 3D2EA 2OW7A 1QWNA 4EZVA 4ATMA 3ZEDA 3OK8A 2F7RA 3KAWA 3C7NA 3D51A 2GAFD 3DYTA 1Y2OA 5C5BA 2OZNB 4M0MA 2F7QA 3BVUA 3T4AG 2GF4A 3BVXA 5KBPA 2Z0NA 4EZWA 4FZOA 3HAHA 2QKWA 3HAJA 3ER9B 2ZXQA 4FZSA 4WPCA 3O3OB 3A98A 5FLEX 2EX3B 2ELBA 3GI7A 4IM0A 3B53X 4IWOA 2F1AA 1TQVA 3BLBA 2F7OA 4JWDA 3BVTA 3QNIA 1TQWA 4R5LA 4B9QA 4BNEA 3BVWA 1WDZA 1URUA 1QWUA 4AKVA 3OWGA 4WPEA 2PMRA 1UPXA 4EZYA 2YIAA 2ALWA 3EJPA 1R5EA 3T46A 1LQ7A 2RT6A 2YLAA 2V0OA 4UDYX 1I4TA 4G6QA 3ABHA
chains in the Genus database with same CATH topology
3I2WA 3HAJA 2RAJA 1WDZA 1URUA 4WPCA 3CAZA 3PLTA 3DYTA 2Q13A 4FZSA 4I1QA 4AKVA 2C08A 4H8SA 2FICA 1ZWWA 2EFKA 1X04A 1Y2OA 4DCNC 3ABHA 4WPEA 5C5BA 3QE6A 3Q0KA 1X03A 2RAKA 3ACOA 3HAIA 2ELBA 2Z0OA 2Q12A 2RAIA 1I49A 3QWEA 4NSWA 1I4DA 2Z0NA 4AVMA 3LLLA 3M3WA 4ATMA 3G9GA 5C5BB 3OK8A 2D4CA 3QNIA 4NQIA 3SOGA 2X3XA 2D1LA 2V0OA 2EFLA 3Q84A 3HAHA 1I4LA 2X3VA 2X3WA 3SYVA 4BNEA 1I4TA 2YKTA 2Z0VA 4DYLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I2W A;  3HAJ A;  2RAJ A;  1WDZ A;  1URU A;  4WPC A;  3CAZ A;  3PLT A;  3DYT A;  2Q13 A;  4FZS A;  4I1Q A;  4AKV A;  2C08 A;  4H8S A;  2FIC A;  1ZWW A;  2EFK A;  1X04 A;  1Y2O A;  4DCN C;  3ABH A;  4WPE A;  5C5B A;  3QE6 A;  3Q0K A;  1X03 A;  2RAK A;  3ACO A;  3HAI A;  2ELB A;  2Z0O A;  2Q12 A;  2RAI A;  1I49 A;  3QWE A;  4NSW A;  1I4D A;  2Z0N A;  4AVM A;  3LLL A;  3M3W A;  4ATM A;  3G9G A;  5C5B B;  3OK8 A;  2D4C A;  3QNI A;  4NQI A;  3SOG A;  2X3X A;  2D1L A;  2V0O A;  2EFL A;  3Q84 A;  3HAH A;  1I4L A;  2X3V A;  2X3W A;  3SYV A;  4BNE A;  1I4T A;  2YKT A;  2Z0V A;  4DYL A; 
#chains in the Genus database with same CATH topology
 2YI8 A;  3CAZ A;  3PLT A;  4I1Q A;  3CKD A;  1SUF A;  3EJQ A;  4DCN C;  2MI7 A;  1GNL A;  3DX4 A;  3HAI A;  2WIN M;  2OBL A;  3BUI A;  4JN4 A;  3ERC C;  1E1D A;  3O3N B;  1HXK A;  3VKH A;  4IW0 A;  3RV0 A;  4DYL A;  3D50 A;  3T48 A;  1R34 A;  3RPM A;  3D4Z A;  3VEA A;  4FM3 A;  2OW6 A;  1TQT A;  4R5J A;  3EJT A;  3QWE A;  4IM3 A;  4AZ5 A;  2D4C A;  4EZS A;  2F1B A;  2EFL A;  4JWE A;  1W9M A;  4F01 A;  3CZN A;  1QX1 A;  2QFF A;  2Q13 A;  4JNE A;  1GNT A;  4EZZ A;  2Z0O A;  4R5G A;  2YI9 A;  3EJU A;  2WYI A;  3LLL A;  3LVT A;  1O7D C;  3UIT A;  4AZI A;  1I4L A;  5E84 A;  4EZQ A;  2PY6 A;  1TQU A;  2O0I 1;  3O3M B;  2N3K A;  3Q0K A;  2JNK A;  2LM0 A;  2FYV A;  3LMF A;  3RV1 A;  3EJR A;  3FD9 A;  2JNS A;  3M3W A;  1DKY A;  4UDX X;  1YWM A;  3Q84 A;  4E81 A;  2KHO A;  4JL9 A;  3BUB A;  3ACO A;  2ND1 A;  4HY9 A;  4NSW A;  4AZ7 A;  3L3P A;  5TKY A;  4JWC A;  4AZB A;  2GA9 D;  3DDG A;  2WYH A;  2YL8 A;  2YLL A;  4H8S A;  1X04 A;  4FZP A;  4HR1 A;  2X5C A;  1JQK A;  4EZN A;  2Q12 A;  4JLC A;  3CZS A;  1SU6 A;  1HWW A;  3DPP A;  3F7W A;  4EZT A;  1I4D A;  3CV5 A;  4IWQ A;  2D1L A;  4HR1 B;  3I01 A;  4NPH A;  3BVV A;  3DPQ A;  1O7D B;  4EZO A;  2YL5 A;  3I04 A;  3D4Y A;  4H6H A;  1MJG A;  4AVM A;  2YL9 A;  3G9G A;  1SU7 A;  4NQI A;  5FIG A;  2X3V A;  3T49 A;  4EZR A;  1DKZ A;  4AZC B;  3I2W A;  2F7P A;  2FIC A;  2EFK A;  2RAK A;  3CVR A;  1I49 A;  2EWF A;  4EZX A;  3BUQ A;  4EZU A;  3SYV A;  3D2F A;  2Z0V A;  3DX0 A;  4PO2 A;  1OA1 A;  2YL6 A;  2YIV X;  2NCZ A;  1X03 A;  4KIK A;  1SU8 A;  4JNF A;  4JWI A;  2ND0 A;  4IM2 A;  5C5B B;  1HTY A;  2F18 A;  4KIK B;  3D52 A;  3L3O M;  3OHX M;  3KDR A;  3ER8 C;  3DX1 A;  3QE6 A;  1R33 A;  4F00 A;  1E2U A;  2LXY A;  1U00 A;  4HYB A;  3QA8 A;  2RAJ A;  1PS3 A;  1OA0 A;  3DPO A;  1E9V A;  1OAO A;  4R5I A;  2Z8Y A;  1ZYL A;  2OBM A;  4EZP A;  3EJS A;  2X3X A;  3VEB A;  2X3W A;  3T47 A;  3I39 X;  3DX3 A;  2QXL A;  3KAV A;  1DKX A;  2C08 A;  3DDF A;  4E3C A;  1ZWW A;  2YIB A;  1GN9 A;  4AZ6 A;  4IWP A;  4AZC A;  3SOG A;  3BUD A;  3B52 X;  4R5K A;  2YKT A;  3QNJ A;  4AZH A;  4AZG A;  1TQS A;  3DX2 A;  3B51 X;  4D8J A;  2OO2 A;  2RAI A;  4H6I A;  3BUP A;  3D2E A;  2OW7 A;  1QWN A;  4EZV A;  4ATM A;  3ZED A;  3OK8 A;  2F7R A;  3KAW A;  3C7N A;  3D51 A;  2GAF D;  3DYT A;  1Y2O A;  5C5B A;  2OZN B;  4M0M A;  2F7Q A;  3BVU A;  3T4A G;  2GF4 A;  3BVX A;  5KBP A;  2Z0N A;  4EZW A;  4FZO A;  3HAH A;  2QKW A;  3HAJ A;  3ER9 B;  2ZXQ A;  4FZS A;  4WPC A;  3O3O B;  3A98 A;  5FLE X;  2EX3 B;  2ELB A;  3GI7 A;  4IM0 A;  3B53 X;  4IWO A;  2F1A A;  1TQV A;  3BLB A;  2F7O A;  4JWD A;  3BVT A;  3QNI A;  1TQW A;  4R5L A;  4B9Q A;  4BNE A;  3BVW A;  1WDZ A;  1URU A;  1QWU A;  4AKV A;  3OWG A;  4WPE A;  2PMR A;  1UPX A;  4EZY A;  2YIA A;  2ALW A;  3EJP A;  1R5E A;  3T46 A;  1LQ7 A;  2RT6 A;  2YLA A;  2V0O A;  4UDY X;  1I4T A;  4G6Q A;  3ABH A; 
#chains in the Genus database with same CATH homology
 3I2W A;  3HAJ A;  2RAJ A;  1WDZ A;  1URU A;  4WPC A;  3CAZ A;  3PLT A;  3DYT A;  2Q13 A;  4FZS A;  4I1Q A;  4AKV A;  2C08 A;  4H8S A;  2FIC A;  1ZWW A;  2EFK A;  1X04 A;  1Y2O A;  4DCN C;  3ABH A;  4WPE A;  5C5B A;  3QE6 A;  3Q0K A;  1X03 A;  2RAK A;  3ACO A;  3HAI A;  2ELB A;  2Z0O A;  2Q12 A;  2RAI A;  1I49 A;  3QWE A;  4NSW A;  1I4D A;  2Z0N A;  4AVM A;  3LLL A;  3M3W A;  4ATM A;  3G9G A;  5C5B B;  3OK8 A;  2D4C A;  3QNI A;  4NQI A;  3SOG A;  2X3X A;  2D1L A;  2V0O A;  2EFL A;  3Q84 A;  3HAH A;  1I4L A;  2X3V A;  2X3W A;  3SYV A;  4BNE A;  1I4T A;  2YKT A;  2Z0V A;  4DYL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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