2D1LA

Structure of f-actin binding domain imd of mim (missing in metastasis)
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
249
structure length
249
Chain Sequence
AGHMEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the actin-binding function of missing-in-metastasis
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords Metastasis suppressor protein 1
total genus 101
structure length 249
sequence length 249
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08397 IMD IRSp53/MIM homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2d1lA00
3Q84A 2D4CA 3SYVA 2X3VA 2X3WA 2Q12A 3ACOA 3CAZA 3HAHA 1X03A 3DYTA 4DCNC 4H8SA 5C5BB 2RAKA 2Z0NA 1URUA 3I2WA 3ABHA 3LLLA 4ATMA 2RAIA 3HAIA 4I1QA 1I4TA 2V0OA 1Y2OA 3QWEA 2X3XA 4FZSA 2Z0VA 4DYLA 3HAJA 2Q13A 5C5BA 3Q0KA 3QE6A 3M3WA 3G9GA 3QNIA 4BNEA 2EFKA 2C08A 2EFLA 1ZWWA 2D1LA 2YKTA 3PLTA 4NQIA 4WPEA 4WPCA 3OK8A 2FICA 1X04A 3SOGA 4AKVA 4AVMA 2RAJA 1I4DA 1I49A 1WDZA 4NSWA 1I4LA 2Z0OA 2ELBA
chains in the Genus database with same CATH superfamily
1OA1A 2ZXQA 2WINM 4R5LA 4AZGA 4ATMA 4M0MA 3L3OM 4PO2A 2NCZA 3CZSA 3ER8C 4HR1A 4R5GA 1R5EA 4IM0A 4IW0A 1GN9A 3VKHA 4AZCB 2ELBA 1OAOA 3D4ZA 4H8SA 4FZPA 3OWGA 4HR1B 3QWEA 4FZSA 3PLTA 3T46A 2YKTA 3D2EA 4JN4A 2Z8YA 3FD9A 5E84A 3SYVA 2X3VA 3KAWA 2YIVX 1JQKA 2O0I1 4FZOA 3HAIA 4R5JA 1PS3A 1E9VA 3M3WA 3DX4A 4BNEA 1W9MA 2F7OA 1QX1A 3CKDA 2RAJA 1I49A 1I4LA 1TQTA 4H6HA 3DDFA 2YL5A 2GF4A 3Q84A 1QWNA 2F1AA 4EZOA 2LXYA 2WYHA 2Z0VA 2PMRA 4EZNA 2KHOA 3I01A 4HY9A 3BUPA 3RV1A 3B53X 4NSWA 4AZBA 1TQSA 4AZ6A 2YI8A 2QXLA 3EJUA 4EZPA 1HXKA 4E3CA 4IM2A 3DPPA 1TQUA 3T4AG 3DDGA 3KAVA 4UDYX 3BVVA 5FLEX 3O3MB 4I1QA 3C7NA 1Y2OA 1SU6A 1DKYA 3QNIA 2EFKA 2OBLA 2QKWA 2YL9A 2YL8A 4B9QA 3KDRA 1O7DC 2X3WA 1SU7A 4HYBA 2RAIA 4NPHA 2F7QA 4R5IA 4AZ5A 3Q0KA 2OZNB 4NQIA 5TKYA 4AKVA 1GNLA 4H6IA 2YLAA 3A98A 1HTYA 2ALWA 3D51A 4DCNC 3LMFA 2F7RA 3O3OB 4R5KA 3DX0A 1SU8A 2D1LA 2OW6A 3EJPA 1U00A 4G6QA 3EJSA 3B52X 3BVWA 1E2UA 4AZIA 1E1DA 1I4TA 2X3XA 3QE6A 4EZUA 1MJGA 2OO2A 2YI9A 2EFLA 2ND0A 3UITA 2FICA 1X04A 4KIKA 2RT6A 3BUQA 1LQ7A 3I39X 4D8JA 2JNSA 3T48A 2Q12A 1UPXA 3BUIA 3DPQA 3ER9B 3LVTA 2FYVA 4KIKB 3BVXA 1DKZA 1HWWA 4EZYA 4WPEA 2EWFA 3OK8A 2EX3B 3DPOA 4IWOA 3BUDA 1GNTA 3DX2A 3ACOA 3F7WA 1DKXA 3GI7A 4F00A 3QA8A 4JWDA 3RPMA 2MI7A 3D52A 3CZNA 2WYIA 4JLCA 3O3NB 1SUFA 5C5BA 2Q13A 4IWQA 4WPCA 4JWIA 3CV5A 4EZVA 3SOGA 2YIAA 4AZCA 2PY6A 5C5BB 3ABHA 3LLLA 4EZRA 4JNEA 1ZWWA 4JWEA 2F7PA 3BUBA 2GAFD 4F01A 4AZ7A 1R33A 4IM3A 2D4CA 4EZWA 3ERCC 4EZTA 3EJQA 1URUA 1TQWA 2YL6A 3T47A 3DX1A 2JNKA 4IWPA 2F18A 1ZYLA 4JL9A 1YWMA 1O7DB 2Z0OA 3T49A 3CAZA 3BLBA 1X03A 3QNJA 3ZEDA 1QWUA 4EZSA 2RAKA 2Z0NA 2YIBA 3RV0A 4JNFA 3BVUA 3BVTA 2QFFA 2OW7A 1OA0A 2N3KA 1WDZA 1TQVA 4UDXX 3DX3A 4EZZA 3DYTA 4EZXA 2OBMA 3VEBA 3L3PA 5FIGA 4E81A 3EJRA 2C08A 3CVRA 4EZQA 4AZHA 1I4DA 4JWCA 2LM0A 3B51X 3D50A 3I04A 3HAHA 2X5CA 2F1BA 3I2WA 3OHXM 3VEAA 3D4YA 5KBPA 2V0OA 2YLLA 4DYLA 3HAJA 3G9GA 2GA9D 2ND1A 3D2FA 1R34A 4AVMA 3EJTA 4FM3A
chains in the Genus database with same CATH topology
3Q84A 2D4CA 3SYVA 2X3VA 2X3WA 2Q12A 3ACOA 3CAZA 3HAHA 1X03A 3DYTA 4DCNC 4H8SA 5C5BB 2RAKA 2Z0NA 1URUA 3I2WA 3ABHA 3LLLA 4ATMA 2RAIA 3HAIA 4I1QA 1I4TA 2V0OA 1Y2OA 3QWEA 2X3XA 4FZSA 2Z0VA 4DYLA 3HAJA 2Q13A 5C5BA 3Q0KA 3QE6A 3M3WA 3G9GA 3QNIA 4BNEA 2EFKA 2C08A 2EFLA 1ZWWA 2D1LA 2YKTA 3PLTA 4NQIA 4WPEA 4WPCA 3OK8A 2FICA 1X04A 3SOGA 4AKVA 4AVMA 2RAJA 1I4DA 1I49A 1WDZA 4NSWA 1I4LA 2Z0OA 2ELBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q84 A;  2D4C A;  3SYV A;  2X3V A;  2X3W A;  2Q12 A;  3ACO A;  3CAZ A;  3HAH A;  1X03 A;  3DYT A;  4DCN C;  4H8S A;  5C5B B;  2RAK A;  2Z0N A;  1URU A;  3I2W A;  3ABH A;  3LLL A;  4ATM A;  2RAI A;  3HAI A;  4I1Q A;  1I4T A;  2V0O A;  1Y2O A;  3QWE A;  2X3X A;  4FZS A;  2Z0V A;  4DYL A;  3HAJ A;  2Q13 A;  5C5B A;  3Q0K A;  3QE6 A;  3M3W A;  3G9G A;  3QNI A;  4BNE A;  2EFK A;  2C08 A;  2EFL A;  1ZWW A;  2D1L A;  2YKT A;  3PLT A;  4NQI A;  4WPE A;  4WPC A;  3OK8 A;  2FIC A;  1X04 A;  3SOG A;  4AKV A;  4AVM A;  2RAJ A;  1I4D A;  1I49 A;  1WDZ A;  4NSW A;  1I4L A;  2Z0O A;  2ELB A; 
#chains in the Genus database with same CATH topology
 1OA1 A;  2ZXQ A;  2WIN M;  4R5L A;  4AZG A;  4ATM A;  4M0M A;  3L3O M;  4PO2 A;  2NCZ A;  3CZS A;  3ER8 C;  4HR1 A;  4R5G A;  1R5E A;  4IM0 A;  4IW0 A;  1GN9 A;  3VKH A;  4AZC B;  2ELB A;  1OAO A;  3D4Z A;  4H8S A;  4FZP A;  3OWG A;  4HR1 B;  3QWE A;  4FZS A;  3PLT A;  3T46 A;  2YKT A;  3D2E A;  4JN4 A;  2Z8Y A;  3FD9 A;  5E84 A;  3SYV A;  2X3V A;  3KAW A;  2YIV X;  1JQK A;  2O0I 1;  4FZO A;  3HAI A;  4R5J A;  1PS3 A;  1E9V A;  3M3W A;  3DX4 A;  4BNE A;  1W9M A;  2F7O A;  1QX1 A;  3CKD A;  2RAJ A;  1I49 A;  1I4L A;  1TQT A;  4H6H A;  3DDF A;  2YL5 A;  2GF4 A;  3Q84 A;  1QWN A;  2F1A A;  4EZO A;  2LXY A;  2WYH A;  2Z0V A;  2PMR A;  4EZN A;  2KHO A;  3I01 A;  4HY9 A;  3BUP A;  3RV1 A;  3B53 X;  4NSW A;  4AZB A;  1TQS A;  4AZ6 A;  2YI8 A;  2QXL A;  3EJU A;  4EZP A;  1HXK A;  4E3C A;  4IM2 A;  3DPP A;  1TQU A;  3T4A G;  3DDG A;  3KAV A;  4UDY X;  3BVV A;  5FLE X;  3O3M B;  4I1Q A;  3C7N A;  1Y2O A;  1SU6 A;  1DKY A;  3QNI A;  2EFK A;  2OBL A;  2QKW A;  2YL9 A;  2YL8 A;  4B9Q A;  3KDR A;  1O7D C;  2X3W A;  1SU7 A;  4HYB A;  2RAI A;  4NPH A;  2F7Q A;  4R5I A;  4AZ5 A;  3Q0K A;  2OZN B;  4NQI A;  5TKY A;  4AKV A;  1GNL A;  4H6I A;  2YLA A;  3A98 A;  1HTY A;  2ALW A;  3D51 A;  4DCN C;  3LMF A;  2F7R A;  3O3O B;  4R5K A;  3DX0 A;  1SU8 A;  2D1L A;  2OW6 A;  3EJP A;  1U00 A;  4G6Q A;  3EJS A;  3B52 X;  3BVW A;  1E2U A;  4AZI A;  1E1D A;  1I4T A;  2X3X A;  3QE6 A;  4EZU A;  1MJG A;  2OO2 A;  2YI9 A;  2EFL A;  2ND0 A;  3UIT A;  2FIC A;  1X04 A;  4KIK A;  2RT6 A;  3BUQ A;  1LQ7 A;  3I39 X;  4D8J A;  2JNS A;  3T48 A;  2Q12 A;  1UPX A;  3BUI A;  3DPQ A;  3ER9 B;  3LVT A;  2FYV A;  4KIK B;  3BVX A;  1DKZ A;  1HWW A;  4EZY A;  4WPE A;  2EWF A;  3OK8 A;  2EX3 B;  3DPO A;  4IWO A;  3BUD A;  1GNT A;  3DX2 A;  3ACO A;  3F7W A;  1DKX A;  3GI7 A;  4F00 A;  3QA8 A;  4JWD A;  3RPM A;  2MI7 A;  3D52 A;  3CZN A;  2WYI A;  4JLC A;  3O3N B;  1SUF A;  5C5B A;  2Q13 A;  4IWQ A;  4WPC A;  4JWI A;  3CV5 A;  4EZV A;  3SOG A;  2YIA A;  4AZC A;  2PY6 A;  5C5B B;  3ABH A;  3LLL A;  4EZR A;  4JNE A;  1ZWW A;  4JWE A;  2F7P A;  3BUB A;  2GAF D;  4F01 A;  4AZ7 A;  1R33 A;  4IM3 A;  2D4C A;  4EZW A;  3ERC C;  4EZT A;  3EJQ A;  1URU A;  1TQW A;  2YL6 A;  3T47 A;  3DX1 A;  2JNK A;  4IWP A;  2F18 A;  1ZYL A;  4JL9 A;  1YWM A;  1O7D B;  2Z0O A;  3T49 A;  3CAZ A;  3BLB A;  1X03 A;  3QNJ A;  3ZED A;  1QWU A;  4EZS A;  2RAK A;  2Z0N A;  2YIB A;  3RV0 A;  4JNF A;  3BVU A;  3BVT A;  2QFF A;  2OW7 A;  1OA0 A;  2N3K A;  1WDZ A;  1TQV A;  4UDX X;  3DX3 A;  4EZZ A;  3DYT A;  4EZX A;  2OBM A;  3VEB A;  3L3P A;  5FIG A;  4E81 A;  3EJR A;  2C08 A;  3CVR A;  4EZQ A;  4AZH A;  1I4D A;  4JWC A;  2LM0 A;  3B51 X;  3D50 A;  3I04 A;  3HAH A;  2X5C A;  2F1B A;  3I2W A;  3OHX M;  3VEA A;  3D4Y A;  5KBP A;  2V0O A;  2YLL A;  4DYL A;  3HAJ A;  3G9G A;  2GA9 D;  2ND1 A;  3D2F A;  1R34 A;  4AVM A;  3EJT A;  4FM3 A; 
#chains in the Genus database with same CATH homology
 3Q84 A;  2D4C A;  3SYV A;  2X3V A;  2X3W A;  2Q12 A;  3ACO A;  3CAZ A;  3HAH A;  1X03 A;  3DYT A;  4DCN C;  4H8S A;  5C5B B;  2RAK A;  2Z0N A;  1URU A;  3I2W A;  3ABH A;  3LLL A;  4ATM A;  2RAI A;  3HAI A;  4I1Q A;  1I4T A;  2V0O A;  1Y2O A;  3QWE A;  2X3X A;  4FZS A;  2Z0V A;  4DYL A;  3HAJ A;  2Q13 A;  5C5B A;  3Q0K A;  3QE6 A;  3M3W A;  3G9G A;  3QNI A;  4BNE A;  2EFK A;  2C08 A;  2EFL A;  1ZWW A;  2D1L A;  2YKT A;  3PLT A;  4NQI A;  4WPE A;  4WPC A;  3OK8 A;  2FIC A;  1X04 A;  3SOG A;  4AKV A;  4AVM A;  2RAJ A;  1I4D A;  1I49 A;  1WDZ A;  4NSW A;  1I4L A;  2Z0O A;  2ELB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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