2EFKA

Crystal structure of the efc domain of cdc42-interacting protein 4
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
280
structure length
273
Chain Sequence
GQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
pubmed doi rcsb
molecule tags Endocytosis/exocytosis
source organism Homo sapiens
molecule keywords Cdc42-interacting protein 4
total genus 118
structure length 273
sequence length 280
ec nomenclature
pdb deposition date 2007-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00611 FCH Fes/CIP4, and EFC/F-BAR homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2efkA01
1WDZA 4NSWA 2X3VA 3SOGA 4NQIA 1URUA 2Z0NA 2Q13A 3HAJA 4ATMA 3ACOA 3LLLA 2EFKA 2X3XA 1X03A 2RAJA 2V0OA 3OK8A 2Q12A 2D1LA 3QE6A 1Y2OA 4WPEA 2EFLA 1I4LA 2D4CA 4I1QA 2YKTA 3M3WA 2X3WA 3Q84A 3SYVA 2Z0VA 2Z0OA 1ZWWA 4WPCA 4BNEA 2ELBA 3HAHA 5C5BB 4DCNC 3ABHA 3QNIA 3HAIA 3PLTA 3CAZA 1X04A 3Q0KA 3QWEA 4DYLA 2RAKA 3DYTA 4H8SA 5C5BA 1I4TA 3G9GA 2C08A 2RAIA 1I4DA 4AVMA 3I2WA 4FZSA 4AKVA 1I49A 2FICA
chains in the Genus database with same CATH superfamily
1R34A 4EZXA 2Z0NA 3EJSA 3HAJA 4EZYA 5FIGA 1OA1A 2D4CA 3DPPA 1LQ7A 3L3PA 4IW0A 2YI8A 1HXKA 3VEBA 1PS3A 2F18A 4JWCA 4AZGA 2PY6A 3O3NB 3T4AG 4IM2A 4IWPA 4ATMA 3QNJA 4EZSA 2OBLA 2OW7A 2YIBA 2X3XA 4B9QA 3EJTA 4EZRA 4UDYX 2YL9A 1TQSA 3LMFA 2N3KA 3Q0KA 3BUDA 4DYLA 3DYTA 3QA8A 3SOGA 3CVRA 1SUFA 3LLLA 2YI9A 1GNTA 2Z0OA 4WPCA 5C5BB 1DKXA 1OAOA 3B53X 4R5GA 3HAIA 3BVXA 1E1DA 3BUIA 2YLAA 3D2EA 1I4TA 1GNLA 4FZSA 4AKVA 4G6QA 3VEAA 3F7WA 4KIKA 2EFKA 3T46A 3RV0A 4AZCA 3I39X 3T47A 2NCZA 4EZTA 2OBMA 3I2WA 3D52A 4PO2A 3ERCC 2X3VA 5TKYA 3DDGA 2EX3B 4HR1A 2Q13A 3OK8A 2QKWA 2D1LA 1QX1A 3KDRA 3EJUA 4JNFA 4E3CA 4BNEA 1W9MA 3LVTA 4IM3A 5E84A 1SU7A 3C7NA 2YIVX 3D2FA 3Q84A 2F7QA 3DX2A 3ZEDA 2WINM 2RT6A 4M0MA 3DDFA 3GI7A 4AZ6A 4H6IA 1DKZA 3OHXM 3DX1A 2WYIA 2WYHA 4AZBA 3DX3A 5FLEX 1O7DB 2O0I1 2F7OA 4AZ5A 3BVTA 2F1BA 2OW6A 1I4DA 4KIKB 4JWEA 1ZYLA 1HWWA 3ER8C 3B51X 2YL6A 4AZCB 4F01A 1I4LA 3SYVA 2X3WA 4EZUA 4JLCA 2F7PA 2ND1A 4AZHA 4JNEA 4FZOA 3T48A 4HR1B 2EWFA 3G9GA 3FD9A 4JL9A 3CZSA 1I49A 3EJQA 4NQIA 3BUQA 2Z8YA 2GA9D 2RAJA 4R5JA 4WPEA 4F00A 4H6HA 1U00A 4AZ7A 4UDXX 3CV5A 2FYVA 2QXLA 2JNKA 1UPXA 3T49A 4EZNA 2V0OA 4R5KA 2EFLA 4I1QA 1DKYA 1YWMA 3DPQA 4IWQA 4R5LA 1R33A 2KHOA 4E81A 2LXYA 2GAFD 2F1AA 3O3OB 2JNSA 1TQWA 4R5IA 4D8JA 3B52X 2ELBA 3UITA 3L3OM 4FM3A 3O3MB 3CZNA 2YLLA 4IM0A 2OZNB 2QFFA 3VKHA 3D50A 4AVMA 2YL8A 1WDZA 4NSWA 1X03A 4FZPA 2MI7A 1QWUA 3DX0A 4NPHA 4EZZA 3ABHA 3QNIA 1X04A 3DPOA 4EZWA 3OWGA 3KAVA 2YL5A 1OA0A 2LM0A 2YKTA 3RPMA 2X5CA 1ZWWA 3EJRA 1JQKA 3PLTA 4JN4A 1HTYA 3RV1A 3QWEA 4HY9A 3ACOA 1TQVA 2PMRA 1URUA 2GF4A 3ER9B 1SU6A 5KBPA 1E9VA 4JWIA 4HYBA 1TQUA 3I01A 3A98A 2YIAA 2ZXQA 1MJGA 3D4YA 2ALWA 2C08A 4EZOA 3EJPA 3BUPA 3BVUA 3D51A 1E2UA 2Q12A 1Y2OA 4EZPA 1SU8A 2Z0VA 4EZQA 3CKDA 3BVVA 3I04A 4DCNC 1GN9A 3D4ZA 5C5BA 2RAIA 4EZVA 2FICA 1TQTA 3QE6A 2ND0A 3BLBA 3M3WA 3BUBA 2F7RA 3HAHA 1R5EA 3DX4A 3CAZA 3BVWA 3KAWA 1O7DC 2RAKA 4H8SA 4JWDA 2OO2A 4AZIA 1QWNA 4IWOA
chains in the Genus database with same CATH topology
1WDZA 4NSWA 2X3VA 3SOGA 4NQIA 1URUA 2Z0NA 2Q13A 3HAJA 4ATMA 3ACOA 3LLLA 2EFKA 2X3XA 1X03A 2RAJA 2V0OA 3OK8A 2Q12A 2D1LA 3QE6A 1Y2OA 4WPEA 2EFLA 1I4LA 2D4CA 4I1QA 2YKTA 3M3WA 2X3WA 3Q84A 3SYVA 2Z0VA 2Z0OA 1ZWWA 4WPCA 4BNEA 2ELBA 3HAHA 5C5BB 4DCNC 3ABHA 3QNIA 3HAIA 3PLTA 3CAZA 1X04A 3Q0KA 3QWEA 4DYLA 2RAKA 3DYTA 4H8SA 5C5BA 1I4TA 3G9GA 2C08A 2RAIA 1I4DA 4AVMA 3I2WA 4FZSA 4AKVA 1I49A 2FICA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WDZ A;  4NSW A;  2X3V A;  3SOG A;  4NQI A;  1URU A;  2Z0N A;  2Q13 A;  3HAJ A;  4ATM A;  3ACO A;  3LLL A;  2EFK A;  2X3X A;  1X03 A;  2RAJ A;  2V0O A;  3OK8 A;  2Q12 A;  2D1L A;  3QE6 A;  1Y2O A;  4WPE A;  2EFL A;  1I4L A;  2D4C A;  4I1Q A;  2YKT A;  3M3W A;  2X3W A;  3Q84 A;  3SYV A;  2Z0V A;  2Z0O A;  1ZWW A;  4WPC A;  4BNE A;  2ELB A;  3HAH A;  5C5B B;  4DCN C;  3ABH A;  3QNI A;  3HAI A;  3PLT A;  3CAZ A;  1X04 A;  3Q0K A;  3QWE A;  4DYL A;  2RAK A;  3DYT A;  4H8S A;  5C5B A;  1I4T A;  3G9G A;  2C08 A;  2RAI A;  1I4D A;  4AVM A;  3I2W A;  4FZS A;  4AKV A;  1I49 A;  2FIC A; 
#chains in the Genus database with same CATH topology
 1R34 A;  4EZX A;  2Z0N A;  3EJS A;  3HAJ A;  4EZY A;  5FIG A;  1OA1 A;  2D4C A;  3DPP A;  1LQ7 A;  3L3P A;  4IW0 A;  2YI8 A;  1HXK A;  3VEB A;  1PS3 A;  2F18 A;  4JWC A;  4AZG A;  2PY6 A;  3O3N B;  3T4A G;  4IM2 A;  4IWP A;  4ATM A;  3QNJ A;  4EZS A;  2OBL A;  2OW7 A;  2YIB A;  2X3X A;  4B9Q A;  3EJT A;  4EZR A;  4UDY X;  2YL9 A;  1TQS A;  3LMF A;  2N3K A;  3Q0K A;  3BUD A;  4DYL A;  3DYT A;  3QA8 A;  3SOG A;  3CVR A;  1SUF A;  3LLL A;  2YI9 A;  1GNT A;  2Z0O A;  4WPC A;  5C5B B;  1DKX A;  1OAO A;  3B53 X;  4R5G A;  3HAI A;  3BVX A;  1E1D A;  3BUI A;  2YLA A;  3D2E A;  1I4T A;  1GNL A;  4FZS A;  4AKV A;  4G6Q A;  3VEA A;  3F7W A;  4KIK A;  2EFK A;  3T46 A;  3RV0 A;  4AZC A;  3I39 X;  3T47 A;  2NCZ A;  4EZT A;  2OBM A;  3I2W A;  3D52 A;  4PO2 A;  3ERC C;  2X3V A;  5TKY A;  3DDG A;  2EX3 B;  4HR1 A;  2Q13 A;  3OK8 A;  2QKW A;  2D1L A;  1QX1 A;  3KDR A;  3EJU A;  4JNF A;  4E3C A;  4BNE A;  1W9M A;  3LVT A;  4IM3 A;  5E84 A;  1SU7 A;  3C7N A;  2YIV X;  3D2F A;  3Q84 A;  2F7Q A;  3DX2 A;  3ZED A;  2WIN M;  2RT6 A;  4M0M A;  3DDF A;  3GI7 A;  4AZ6 A;  4H6I A;  1DKZ A;  3OHX M;  3DX1 A;  2WYI A;  2WYH A;  4AZB A;  3DX3 A;  5FLE X;  1O7D B;  2O0I 1;  2F7O A;  4AZ5 A;  3BVT A;  2F1B A;  2OW6 A;  1I4D A;  4KIK B;  4JWE A;  1ZYL A;  1HWW A;  3ER8 C;  3B51 X;  2YL6 A;  4AZC B;  4F01 A;  1I4L A;  3SYV A;  2X3W A;  4EZU A;  4JLC A;  2F7P A;  2ND1 A;  4AZH A;  4JNE A;  4FZO A;  3T48 A;  4HR1 B;  2EWF A;  3G9G A;  3FD9 A;  4JL9 A;  3CZS A;  1I49 A;  3EJQ A;  4NQI A;  3BUQ A;  2Z8Y A;  2GA9 D;  2RAJ A;  4R5J A;  4WPE A;  4F00 A;  4H6H A;  1U00 A;  4AZ7 A;  4UDX X;  3CV5 A;  2FYV A;  2QXL A;  2JNK A;  1UPX A;  3T49 A;  4EZN A;  2V0O A;  4R5K A;  2EFL A;  4I1Q A;  1DKY A;  1YWM A;  3DPQ A;  4IWQ A;  4R5L A;  1R33 A;  2KHO A;  4E81 A;  2LXY A;  2GAF D;  2F1A A;  3O3O B;  2JNS A;  1TQW A;  4R5I A;  4D8J A;  3B52 X;  2ELB A;  3UIT A;  3L3O M;  4FM3 A;  3O3M B;  3CZN A;  2YLL A;  4IM0 A;  2OZN B;  2QFF A;  3VKH A;  3D50 A;  4AVM A;  2YL8 A;  1WDZ A;  4NSW A;  1X03 A;  4FZP A;  2MI7 A;  1QWU A;  3DX0 A;  4NPH A;  4EZZ A;  3ABH A;  3QNI A;  1X04 A;  3DPO A;  4EZW A;  3OWG A;  3KAV A;  2YL5 A;  1OA0 A;  2LM0 A;  2YKT A;  3RPM A;  2X5C A;  1ZWW A;  3EJR A;  1JQK A;  3PLT A;  4JN4 A;  1HTY A;  3RV1 A;  3QWE A;  4HY9 A;  3ACO A;  1TQV A;  2PMR A;  1URU A;  2GF4 A;  3ER9 B;  1SU6 A;  5KBP A;  1E9V A;  4JWI A;  4HYB A;  1TQU A;  3I01 A;  3A98 A;  2YIA A;  2ZXQ A;  1MJG A;  3D4Y A;  2ALW A;  2C08 A;  4EZO A;  3EJP A;  3BUP A;  3BVU A;  3D51 A;  1E2U A;  2Q12 A;  1Y2O A;  4EZP A;  1SU8 A;  2Z0V A;  4EZQ A;  3CKD A;  3BVV A;  3I04 A;  4DCN C;  1GN9 A;  3D4Z A;  5C5B A;  2RAI A;  4EZV A;  2FIC A;  1TQT A;  3QE6 A;  2ND0 A;  3BLB A;  3M3W A;  3BUB A;  2F7R A;  3HAH A;  1R5E A;  3DX4 A;  3CAZ A;  3BVW A;  3KAW A;  1O7D C;  2RAK A;  4H8S A;  4JWD A;  2OO2 A;  4AZI A;  1QWN A;  4IWO A; 
#chains in the Genus database with same CATH homology
 1WDZ A;  4NSW A;  2X3V A;  3SOG A;  4NQI A;  1URU A;  2Z0N A;  2Q13 A;  3HAJ A;  4ATM A;  3ACO A;  3LLL A;  2EFK A;  2X3X A;  1X03 A;  2RAJ A;  2V0O A;  3OK8 A;  2Q12 A;  2D1L A;  3QE6 A;  1Y2O A;  4WPE A;  2EFL A;  1I4L A;  2D4C A;  4I1Q A;  2YKT A;  3M3W A;  2X3W A;  3Q84 A;  3SYV A;  2Z0V A;  2Z0O A;  1ZWW A;  4WPC A;  4BNE A;  2ELB A;  3HAH A;  5C5B B;  4DCN C;  3ABH A;  3QNI A;  3HAI A;  3PLT A;  3CAZ A;  1X04 A;  3Q0K A;  3QWE A;  4DYL A;  2RAK A;  3DYT A;  4H8S A;  5C5B A;  1I4T A;  3G9G A;  2C08 A;  2RAI A;  1I4D A;  4AVM A;  3I2W A;  4FZS A;  4AKV A;  1I49 A;  2FIC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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