2EFKA

Crystal structure of the efc domain of cdc42-interacting protein 4
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
280
structure length
273
Chain Sequence
GQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Endocytosis/exocytosis
molecule keywords Cdc42-interacting protein 4
publication title Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis
pubmed doi rcsb
source organism Homo sapiens
total genus 118
structure length 273
sequence length 280
ec nomenclature
pdb deposition date 2007-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00611 FCH Fes/CIP4, and EFC/F-BAR homology domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2efkA01
2ELBA 3ABHA 3SOGA 3LLLA 1URUA 2Q13A 2Q12A 1I4LA 2RAKA 3G9GA 1X03A 2Z0NA 2RAIA 3QE6A 2D1LA 2YKTA 2EFKA 3CAZA 2EFLA 3HAIA 1WDZA 4AKVA 3HAJA 2D4CA 2X3VA 3QWEA 1X04A 2V0OA 1Y2OA 4FZSA 3DYTA 4H8SA 3SYVA 2RAJA 4DYLA 2Z0VA 2Z0OA 3ACOA 2C08A 1I4DA 4BNEA 1ZWWA 3HAHA 4NSWA 3I2WA 1I4TA 2X3XA 4NQIA 4DCNC 4WPEA 4I1QA 3OK8A 1I49A 4WPCA 2FICA 2X3WA 3QNIA 3M3WA 3Q0KA 3Q84A 5C5BA 3PLTA 4ATMA 4AVMA 5C5BB
chains in the Genus database with same CATH superfamily
3SOGA 4EZYA 4AKVA 3T48A 4JWIA 4KIKA 4EZNA 2Z0VA 1ZYLA 1O7DB 1ZWWA 1I4TA 2X3XA 4EZSA 4WPCA 1U00A 4IWQA 1PS3A 2FYVA 2Q13A 4FZPA 3FD9A 4JNFA 3DX4A 4PO2A 4HY9A 3HAHA 3O3OB 3CVRA 1E2UA 3I2WA 4EZVA 2GA9D 3BVUA 3D4YA 1QWNA 1I4LA 3RV1A 3D51A 1SUFA 3BUQA 2QKWA 3T47A 4EZWA 4I1QA 4HR1A 2F1AA 1E9VA 2GF4A 3PLTA 1QWUA 3BVVA 5FLEX 3KAVA 4M0MA 1R5EA 3G9GA 1HWWA 4AZ5A 2D1LA 3QA8A 2WINM 1SU6A 2OBMA 1DKYA 3QWEA 2QFFA 2YI9A 2C08A 3EJPA 2YIVX 2KHOA 3RV0A 1I49A 3CZNA 3Q84A 4ATMA 4D8JA 3CZSA 2PY6A 4AZCB 2JNKA 3HAJA 3B53X 4EZUA 1LQ7A 2Z0OA 1TQTA 2FICA 1TQUA 2F7RA 4IM0A 1URUA 1UPXA 3ER9B 2OBLA 1OAOA 1WDZA 4FM3A 4AZIA 1GNLA 4R5KA 2YLLA 4JNEA 4DCNC 5C5BA 4JWCA 1OA0A 4B9QA 5FIGA 2ELBA 3I01A 4R5JA 3CAZA 2EFLA 3BVXA 3LVTA 2X3VA 2OZNB 3DDGA 3OK8A 4JLCA 2EX3B 3EJRA 5KBPA 4E3CA 3GI7A 4E81A 1TQVA 4EZRA 2YLAA 4H6IA 2RT6A 1SU7A 3ER8C 1Y2OA 3DYTA 4H8SA 2RAJA 4JL9A 4NQIA 2YL8A 4AVMA 4JWDA 1TQSA 2WYHA 3RPMA 5E84A 2YKTA 4AZ6A 3HAIA 4IWOA 3I39X 2NCZA 4R5LA 2Z8YA 3DX1A 1SU8A 4H6HA 2YL6A 4FZOA 2YL5A 2ALWA 2X3WA 1TQWA 2YIAA 2OO2A 1X03A 2ZXQA 1GN9A 3BVTA 3EJQA 3L3PA 4IM2A 4KIKB 1I4DA 3F7WA 3OWGA 3DDFA 3QNIA 3EJTA 4EZXA 4JWEA 1HTYA 2Q12A 1DKXA 2Z0NA 3QE6A 2O0I1 1OA1A 3L3OM 1YWMA 2WYIA 2MI7A 3D2FA 3BUDA 3BUIA 3KAWA 3T49A 1JQKA 3BVWA 1O7DC 4IM3A 2RAKA 4AZCA 3OHXM 3VEAA 3CV5A 2D4CA 2LXYA 4IW0A 4R5IA 3EJUA 3T4AG 4AZGA 4EZOA 2ND0A 4R5GA 2F7PA 4AZBA 1HXKA 3QNJA 3M3WA 4HR1B 3CKDA 2PMRA 3D52A 2GAFD 3EJSA 2ND1A 3DX2A 4F00A 2LM0A 3BUBA 4DYLA 4EZTA 4AZHA 4BNEA 2OW7A 2F7QA 3DPQA 2JNSA 1QX1A 3I04A 3ABHA 1W9MA 3BUPA 2X5CA 2EFKA 3DPPA 4EZQA 4F01A 3VKHA 4AZ7A 3ACOA 2N3KA 4WPEA 2OW6A 3BLBA 1MJGA 4NPHA 1GNTA 3ERCC 2YL9A 3O3NB 5TKYA 1R33A 3DX3A 4EZZA 3UITA 1R34A 2YIBA 2YI8A 3O3MB 3DPOA 3B52X 4JN4A 3D50A 3Q0KA 3B51X 4UDYX 4UDXX 3A98A 4G6QA 2F7OA 2F1BA 5C5BB 4EZPA 2EWFA 3LLLA 3DX0A 3KDRA 2RAIA 3C7NA 4IWPA 3D2EA 3VEBA 3LMFA 1E1DA 3T46A 2QXLA 1X04A 2V0OA 4FZSA 4HYBA 3ZEDA 3SYVA 2F18A 4NSWA 3D4ZA 1DKZA
chains in the Genus database with same CATH topology
2ELBA 3ABHA 3SOGA 3LLLA 1URUA 2Q13A 2Q12A 1I4LA 2RAKA 3G9GA 1X03A 2Z0NA 2RAIA 3QE6A 2D1LA 2YKTA 2EFKA 3CAZA 2EFLA 3HAIA 1WDZA 4AKVA 3HAJA 2D4CA 2X3VA 3QWEA 1X04A 2V0OA 1Y2OA 4FZSA 3DYTA 4H8SA 3SYVA 2RAJA 4DYLA 2Z0VA 2Z0OA 3ACOA 2C08A 1I4DA 4BNEA 1ZWWA 3HAHA 4NSWA 3I2WA 1I4TA 2X3XA 4NQIA 4DCNC 4WPEA 4I1QA 3OK8A 1I49A 4WPCA 2FICA 2X3WA 3QNIA 3M3WA 3Q0KA 3Q84A 5C5BA 3PLTA 4ATMA 4AVMA 5C5BB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ELB A;  3ABH A;  3SOG A;  3LLL A;  1URU A;  2Q13 A;  2Q12 A;  1I4L A;  2RAK A;  3G9G A;  1X03 A;  2Z0N A;  2RAI A;  3QE6 A;  2D1L A;  2YKT A;  2EFK A;  3CAZ A;  2EFL A;  3HAI A;  1WDZ A;  4AKV A;  3HAJ A;  2D4C A;  2X3V A;  3QWE A;  1X04 A;  2V0O A;  1Y2O A;  4FZS A;  3DYT A;  4H8S A;  3SYV A;  2RAJ A;  4DYL A;  2Z0V A;  2Z0O A;  3ACO A;  2C08 A;  1I4D A;  4BNE A;  1ZWW A;  3HAH A;  4NSW A;  3I2W A;  1I4T A;  2X3X A;  4NQI A;  4DCN C;  4WPE A;  4I1Q A;  3OK8 A;  1I49 A;  4WPC A;  2FIC A;  2X3W A;  3QNI A;  3M3W A;  3Q0K A;  3Q84 A;  5C5B A;  3PLT A;  4ATM A;  4AVM A;  5C5B B; 
#chains in the Genus database with same CATH topology
 3SOG A;  4EZY A;  4AKV A;  3T48 A;  4JWI A;  4KIK A;  4EZN A;  2Z0V A;  1ZYL A;  1O7D B;  1ZWW A;  1I4T A;  2X3X A;  4EZS A;  4WPC A;  1U00 A;  4IWQ A;  1PS3 A;  2FYV A;  2Q13 A;  4FZP A;  3FD9 A;  4JNF A;  3DX4 A;  4PO2 A;  4HY9 A;  3HAH A;  3O3O B;  3CVR A;  1E2U A;  3I2W A;  4EZV A;  2GA9 D;  3BVU A;  3D4Y A;  1QWN A;  1I4L A;  3RV1 A;  3D51 A;  1SUF A;  3BUQ A;  2QKW A;  3T47 A;  4EZW A;  4I1Q A;  4HR1 A;  2F1A A;  1E9V A;  2GF4 A;  3PLT A;  1QWU A;  3BVV A;  5FLE X;  3KAV A;  4M0M A;  1R5E A;  3G9G A;  1HWW A;  4AZ5 A;  2D1L A;  3QA8 A;  2WIN M;  1SU6 A;  2OBM A;  1DKY A;  3QWE A;  2QFF A;  2YI9 A;  2C08 A;  3EJP A;  2YIV X;  2KHO A;  3RV0 A;  1I49 A;  3CZN A;  3Q84 A;  4ATM A;  4D8J A;  3CZS A;  2PY6 A;  4AZC B;  2JNK A;  3HAJ A;  3B53 X;  4EZU A;  1LQ7 A;  2Z0O A;  1TQT A;  2FIC A;  1TQU A;  2F7R A;  4IM0 A;  1URU A;  1UPX A;  3ER9 B;  2OBL A;  1OAO A;  1WDZ A;  4FM3 A;  4AZI A;  1GNL A;  4R5K A;  2YLL A;  4JNE A;  4DCN C;  5C5B A;  4JWC A;  1OA0 A;  4B9Q A;  5FIG A;  2ELB A;  3I01 A;  4R5J A;  3CAZ A;  2EFL A;  3BVX A;  3LVT A;  2X3V A;  2OZN B;  3DDG A;  3OK8 A;  4JLC A;  2EX3 B;  3EJR A;  5KBP A;  4E3C A;  3GI7 A;  4E81 A;  1TQV A;  4EZR A;  2YLA A;  4H6I A;  2RT6 A;  1SU7 A;  3ER8 C;  1Y2O A;  3DYT A;  4H8S A;  2RAJ A;  4JL9 A;  4NQI A;  2YL8 A;  4AVM A;  4JWD A;  1TQS A;  2WYH A;  3RPM A;  5E84 A;  2YKT A;  4AZ6 A;  3HAI A;  4IWO A;  3I39 X;  2NCZ A;  4R5L A;  2Z8Y A;  3DX1 A;  1SU8 A;  4H6H A;  2YL6 A;  4FZO A;  2YL5 A;  2ALW A;  2X3W A;  1TQW A;  2YIA A;  2OO2 A;  1X03 A;  2ZXQ A;  1GN9 A;  3BVT A;  3EJQ A;  3L3P A;  4IM2 A;  4KIK B;  1I4D A;  3F7W A;  3OWG A;  3DDF A;  3QNI A;  3EJT A;  4EZX A;  4JWE A;  1HTY A;  2Q12 A;  1DKX A;  2Z0N A;  3QE6 A;  2O0I 1;  1OA1 A;  3L3O M;  1YWM A;  2WYI A;  2MI7 A;  3D2F A;  3BUD A;  3BUI A;  3KAW A;  3T49 A;  1JQK A;  3BVW A;  1O7D C;  4IM3 A;  2RAK A;  4AZC A;  3OHX M;  3VEA A;  3CV5 A;  2D4C A;  2LXY A;  4IW0 A;  4R5I A;  3EJU A;  3T4A G;  4AZG A;  4EZO A;  2ND0 A;  4R5G A;  2F7P A;  4AZB A;  1HXK A;  3QNJ A;  3M3W A;  4HR1 B;  3CKD A;  2PMR A;  3D52 A;  2GAF D;  3EJS A;  2ND1 A;  3DX2 A;  4F00 A;  2LM0 A;  3BUB A;  4DYL A;  4EZT A;  4AZH A;  4BNE A;  2OW7 A;  2F7Q A;  3DPQ A;  2JNS A;  1QX1 A;  3I04 A;  3ABH A;  1W9M A;  3BUP A;  2X5C A;  2EFK A;  3DPP A;  4EZQ A;  4F01 A;  3VKH A;  4AZ7 A;  3ACO A;  2N3K A;  4WPE A;  2OW6 A;  3BLB A;  1MJG A;  4NPH A;  1GNT A;  3ERC C;  2YL9 A;  3O3N B;  5TKY A;  1R33 A;  3DX3 A;  4EZZ A;  3UIT A;  1R34 A;  2YIB A;  2YI8 A;  3O3M B;  3DPO A;  3B52 X;  4JN4 A;  3D50 A;  3Q0K A;  3B51 X;  4UDY X;  4UDX X;  3A98 A;  4G6Q A;  2F7O A;  2F1B A;  5C5B B;  4EZP A;  2EWF A;  3LLL A;  3DX0 A;  3KDR A;  2RAI A;  3C7N A;  4IWP A;  3D2E A;  3VEB A;  3LMF A;  1E1D A;  3T46 A;  2QXL A;  1X04 A;  2V0O A;  4FZS A;  4HYB A;  3ZED A;  3SYV A;  2F18 A;  4NSW A;  3D4Z A;  1DKZ A; 
#chains in the Genus database with same CATH homology
 2ELB A;  3ABH A;  3SOG A;  3LLL A;  1URU A;  2Q13 A;  2Q12 A;  1I4L A;  2RAK A;  3G9G A;  1X03 A;  2Z0N A;  2RAI A;  3QE6 A;  2D1L A;  2YKT A;  2EFK A;  3CAZ A;  2EFL A;  3HAI A;  1WDZ A;  4AKV A;  3HAJ A;  2D4C A;  2X3V A;  3QWE A;  1X04 A;  2V0O A;  1Y2O A;  4FZS A;  3DYT A;  4H8S A;  3SYV A;  2RAJ A;  4DYL A;  2Z0V A;  2Z0O A;  3ACO A;  2C08 A;  1I4D A;  4BNE A;  1ZWW A;  3HAH A;  4NSW A;  3I2W A;  1I4T A;  2X3X A;  4NQI A;  4DCN C;  4WPE A;  4I1Q A;  3OK8 A;  1I49 A;  4WPC A;  2FIC A;  2X3W A;  3QNI A;  3M3W A;  3Q0K A;  3Q84 A;  5C5B A;  3PLT A;  4ATM A;  4AVM A;  5C5B B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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