2Q12A

Crystal structure of bar domain of appl1
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
247
structure length
242
Chain Sequence
LEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEVASD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
pubmed doi rcsb
molecule tags Protein transport
source organism Homo sapiens
molecule keywords DCC-interacting protein 13 alpha
total genus 99
structure length 242
sequence length 247
ec nomenclature
pdb deposition date 2007-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16746 BAR_3 BAR domain of APPL family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2q12A00
1I4TA 3ABHA 3ACOA 2EFKA 2YKTA 3DYTA 3G9GA 3Q84A 4NSWA 2Z0NA 4WPEA 1URUA 1X04A 2RAJA 2X3XA 2X3VA 3HAJA 4I1QA 3SYVA 4AVMA 5C5BA 1WDZA 2D1LA 3I2WA 2RAKA 1X03A 4AKVA 4NQIA 4H8SA 2Q13A 4DCNC 2ELBA 4FZSA 3Q0KA 4WPCA 1I49A 3HAIA 2Q12A 4ATMA 2Z0VA 5C5BB 3QNIA 1ZWWA 1I4DA 2FICA 2D4CA 3SOGA 1Y2OA 3HAHA 3QWEA 4BNEA 3LLLA 2V0OA 3OK8A 3QE6A 2X3WA 1I4LA 2RAIA 2Z0OA 4DYLA 2C08A 2EFLA 3CAZA 3M3WA 3PLTA
chains in the Genus database with same CATH superfamily
5E84A 2WYHA 2YLLA 2YIVX 4WPEA 1SU8A 3HAJA 3ERCC 4IWQA 2D4CA 3KAVA 3QNJA 2OW6A 5KBPA 4UDYX 3ZEDA 4NSWA 2JNSA 3GI7A 2F7RA 3BUQA 3CV5A 1W9MA 3ER8C 2ELBA 4FZSA 1SUFA 2FICA 3O3MB 4D8JA 3DX1A 2YL5A 2EWFA 2YL6A 4JNFA 2GAFD 4AZ5A 3T4AG 4JLCA 4IM2A 2RT6A 1OAOA 4AKVA 3DX2A 4KIKA 1DKYA 3D51A 2GA9D 1GNLA 3RPMA 3T46A 3CAZA 1LQ7A 3D4YA 2F7OA 4EZVA 1HXKA 5FIGA 3SYVA 1TQWA 3DPPA 2X5CA 3T48A 4AZHA 3LMFA 3I39X 3D50A 3FD9A 4AZ6A 4EZUA 2V0OA 3OK8A 3T49A 3I01A 2KHOA 3QE6A 2C08A 3PLTA 2EX3B 1SU6A 2Z8YA 2F1AA 4HYBA 3DYTA 3BVTA 2X3XA 3B51X 4IM3A 4WPCA 2OW7A 3HAIA 4IM0A 3F7WA 3DPOA 4KIKB 1QWUA 1HTYA 2Z0OA 4NPHA 3EJRA 4M0MA 4R5IA 1QWNA 3VKHA 3BLBA 1X04A 4FZPA 2YI8A 4NQIA 2MI7A 4FM3A 3EJSA 3KAWA 1I49A 2F7QA 1PS3A 3T47A 4BNEA 4EZRA 3L3PA 2EFLA 3VEAA 4AZCA 2EFKA 2YL8A 3Q84A 2Z0NA 3DX4A 2RAJA 3O3NB 2Q13A 2YL9A 2F18A 4AZIA 2ND0A 3BUBA 2F7PA 2OZNB 3A98A 4DYLA 4EZWA 4R5GA 1UPXA 4EZQA 4B9QA 2QFFA 3BVUA 1R34A 2WYIA 4E3CA 3DX0A 4H6HA 3CZSA 4HR1A 2QKWA 3BUIA 3EJUA 3CVRA 2RAIA 2WINM 1JQKA 3O3OB 2LXYA 4AZCB 1URUA 5C5BA 3B52X 1U00A 1SU7A 4HY9A 1X03A 2JNKA 4JN4A 4EZPA 4DCNC 4EZYA 4EZZA 4EZOA 3QNIA 1ZWWA 2GF4A 4IW0A 3SOGA 4FZOA 1Y2OA 3BVVA 2N3KA 3EJTA 2FYVA 4G6QA 1YWMA 4IWPA 1TQUA 4H6IA 2PY6A 1ZYLA 2OBMA 2YLAA 2OO2A 1OA0A 1E2UA 4E81A 3I04A 4IWOA 1I4LA 3M3WA 4HR1B 1QX1A 1DKXA 2O0I1 3ACOA 3G9GA 4JL9A 3UITA 2LM0A 2ALWA 1WDZA 2D1LA 2RAKA 3D2EA 4F01A 5C5BB 3DPQA 3LLLA 4AZ7A 2PMRA 2Z0VA 2F1BA 1I4TA 2X3VA 4UDXX 4H8SA 2YI9A 4ATMA 3C7NA 5TKYA 4JWIA 1O7DB 3HAHA 2NCZA 4AZGA 2X3WA 2QXLA 3CZNA 3L3OM 3LVTA 3BUDA 2ND1A 4I1QA 3I2WA 1GNTA 5FLEX 1MJGA 3CKDA 1TQVA 3QWEA 4EZTA 3BUPA 3OWGA 3EJPA 3DDFA 1TQTA 3QA8A 2YKTA 4R5LA 1R5EA 3B53X 4AVMA 3ER9B 2YIBA 2YIAA 4PO2A 4JWDA 3DX3A 1GN9A 3Q0KA 1I4DA 3EJQA 4EZNA 1HWWA 3D4ZA 4EZXA 3KDRA 4JNEA 3OHXM 3VEBA 4AZBA 2Q12A 4JWCA 1R33A 1DKZA 1O7DC 4JWEA 1E1DA 3DDGA 3ABHA 3BVXA 1E9VA 3RV0A 4EZSA 3BVWA 2ZXQA 3D2FA 4F00A 3RV1A 2OBLA 4R5JA 1TQSA 4R5KA 1OA1A 3D52A
chains in the Genus database with same CATH topology
1I4TA 3ABHA 3ACOA 2EFKA 2YKTA 3DYTA 3G9GA 3Q84A 4NSWA 2Z0NA 4WPEA 1URUA 1X04A 2RAJA 2X3XA 2X3VA 3HAJA 4I1QA 3SYVA 4AVMA 5C5BA 1WDZA 2D1LA 3I2WA 2RAKA 1X03A 4AKVA 4NQIA 4H8SA 2Q13A 4DCNC 2ELBA 4FZSA 3Q0KA 4WPCA 1I49A 3HAIA 2Q12A 4ATMA 2Z0VA 5C5BB 3QNIA 1ZWWA 1I4DA 2FICA 2D4CA 3SOGA 1Y2OA 3HAHA 3QWEA 4BNEA 3LLLA 2V0OA 3OK8A 3QE6A 2X3WA 1I4LA 2RAIA 2Z0OA 4DYLA 2C08A 2EFLA 3CAZA 3M3WA 3PLTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I4T A;  3ABH A;  3ACO A;  2EFK A;  2YKT A;  3DYT A;  3G9G A;  3Q84 A;  4NSW A;  2Z0N A;  4WPE A;  1URU A;  1X04 A;  2RAJ A;  2X3X A;  2X3V A;  3HAJ A;  4I1Q A;  3SYV A;  4AVM A;  5C5B A;  1WDZ A;  2D1L A;  3I2W A;  2RAK A;  1X03 A;  4AKV A;  4NQI A;  4H8S A;  2Q13 A;  4DCN C;  2ELB A;  4FZS A;  3Q0K A;  4WPC A;  1I49 A;  3HAI A;  2Q12 A;  4ATM A;  2Z0V A;  5C5B B;  3QNI A;  1ZWW A;  1I4D A;  2FIC A;  2D4C A;  3SOG A;  1Y2O A;  3HAH A;  3QWE A;  4BNE A;  3LLL A;  2V0O A;  3OK8 A;  3QE6 A;  2X3W A;  1I4L A;  2RAI A;  2Z0O A;  4DYL A;  2C08 A;  2EFL A;  3CAZ A;  3M3W A;  3PLT A; 
#chains in the Genus database with same CATH topology
 5E84 A;  2WYH A;  2YLL A;  2YIV X;  4WPE A;  1SU8 A;  3HAJ A;  3ERC C;  4IWQ A;  2D4C A;  3KAV A;  3QNJ A;  2OW6 A;  5KBP A;  4UDY X;  3ZED A;  4NSW A;  2JNS A;  3GI7 A;  2F7R A;  3BUQ A;  3CV5 A;  1W9M A;  3ER8 C;  2ELB A;  4FZS A;  1SUF A;  2FIC A;  3O3M B;  4D8J A;  3DX1 A;  2YL5 A;  2EWF A;  2YL6 A;  4JNF A;  2GAF D;  4AZ5 A;  3T4A G;  4JLC A;  4IM2 A;  2RT6 A;  1OAO A;  4AKV A;  3DX2 A;  4KIK A;  1DKY A;  3D51 A;  2GA9 D;  1GNL A;  3RPM A;  3T46 A;  3CAZ A;  1LQ7 A;  3D4Y A;  2F7O A;  4EZV A;  1HXK A;  5FIG A;  3SYV A;  1TQW A;  3DPP A;  2X5C A;  3T48 A;  4AZH A;  3LMF A;  3I39 X;  3D50 A;  3FD9 A;  4AZ6 A;  4EZU A;  2V0O A;  3OK8 A;  3T49 A;  3I01 A;  2KHO A;  3QE6 A;  2C08 A;  3PLT A;  2EX3 B;  1SU6 A;  2Z8Y A;  2F1A A;  4HYB A;  3DYT A;  3BVT A;  2X3X A;  3B51 X;  4IM3 A;  4WPC A;  2OW7 A;  3HAI A;  4IM0 A;  3F7W A;  3DPO A;  4KIK B;  1QWU A;  1HTY A;  2Z0O A;  4NPH A;  3EJR A;  4M0M A;  4R5I A;  1QWN A;  3VKH A;  3BLB A;  1X04 A;  4FZP A;  2YI8 A;  4NQI A;  2MI7 A;  4FM3 A;  3EJS A;  3KAW A;  1I49 A;  2F7Q A;  1PS3 A;  3T47 A;  4BNE A;  4EZR A;  3L3P A;  2EFL A;  3VEA A;  4AZC A;  2EFK A;  2YL8 A;  3Q84 A;  2Z0N A;  3DX4 A;  2RAJ A;  3O3N B;  2Q13 A;  2YL9 A;  2F18 A;  4AZI A;  2ND0 A;  3BUB A;  2F7P A;  2OZN B;  3A98 A;  4DYL A;  4EZW A;  4R5G A;  1UPX A;  4EZQ A;  4B9Q A;  2QFF A;  3BVU A;  1R34 A;  2WYI A;  4E3C A;  3DX0 A;  4H6H A;  3CZS A;  4HR1 A;  2QKW A;  3BUI A;  3EJU A;  3CVR A;  2RAI A;  2WIN M;  1JQK A;  3O3O B;  2LXY A;  4AZC B;  1URU A;  5C5B A;  3B52 X;  1U00 A;  1SU7 A;  4HY9 A;  1X03 A;  2JNK A;  4JN4 A;  4EZP A;  4DCN C;  4EZY A;  4EZZ A;  4EZO A;  3QNI A;  1ZWW A;  2GF4 A;  4IW0 A;  3SOG A;  4FZO A;  1Y2O A;  3BVV A;  2N3K A;  3EJT A;  2FYV A;  4G6Q A;  1YWM A;  4IWP A;  1TQU A;  4H6I A;  2PY6 A;  1ZYL A;  2OBM A;  2YLA A;  2OO2 A;  1OA0 A;  1E2U A;  4E81 A;  3I04 A;  4IWO A;  1I4L A;  3M3W A;  4HR1 B;  1QX1 A;  1DKX A;  2O0I 1;  3ACO A;  3G9G A;  4JL9 A;  3UIT A;  2LM0 A;  2ALW A;  1WDZ A;  2D1L A;  2RAK A;  3D2E A;  4F01 A;  5C5B B;  3DPQ A;  3LLL A;  4AZ7 A;  2PMR A;  2Z0V A;  2F1B A;  1I4T A;  2X3V A;  4UDX X;  4H8S A;  2YI9 A;  4ATM A;  3C7N A;  5TKY A;  4JWI A;  1O7D B;  3HAH A;  2NCZ A;  4AZG A;  2X3W A;  2QXL A;  3CZN A;  3L3O M;  3LVT A;  3BUD A;  2ND1 A;  4I1Q A;  3I2W A;  1GNT A;  5FLE X;  1MJG A;  3CKD A;  1TQV A;  3QWE A;  4EZT A;  3BUP A;  3OWG A;  3EJP A;  3DDF A;  1TQT A;  3QA8 A;  2YKT A;  4R5L A;  1R5E A;  3B53 X;  4AVM A;  3ER9 B;  2YIB A;  2YIA A;  4PO2 A;  4JWD A;  3DX3 A;  1GN9 A;  3Q0K A;  1I4D A;  3EJQ A;  4EZN A;  1HWW A;  3D4Z A;  4EZX A;  3KDR A;  4JNE A;  3OHX M;  3VEB A;  4AZB A;  2Q12 A;  4JWC A;  1R33 A;  1DKZ A;  1O7D C;  4JWE A;  1E1D A;  3DDG A;  3ABH A;  3BVX A;  1E9V A;  3RV0 A;  4EZS A;  3BVW A;  2ZXQ A;  3D2F A;  4F00 A;  3RV1 A;  2OBL A;  4R5J A;  1TQS A;  4R5K A;  1OA1 A;  3D52 A; 
#chains in the Genus database with same CATH homology
 1I4T A;  3ABH A;  3ACO A;  2EFK A;  2YKT A;  3DYT A;  3G9G A;  3Q84 A;  4NSW A;  2Z0N A;  4WPE A;  1URU A;  1X04 A;  2RAJ A;  2X3X A;  2X3V A;  3HAJ A;  4I1Q A;  3SYV A;  4AVM A;  5C5B A;  1WDZ A;  2D1L A;  3I2W A;  2RAK A;  1X03 A;  4AKV A;  4NQI A;  4H8S A;  2Q13 A;  4DCN C;  2ELB A;  4FZS A;  3Q0K A;  4WPC A;  1I49 A;  3HAI A;  2Q12 A;  4ATM A;  2Z0V A;  5C5B B;  3QNI A;  1ZWW A;  1I4D A;  2FIC A;  2D4C A;  3SOG A;  1Y2O A;  3HAH A;  3QWE A;  4BNE A;  3LLL A;  2V0O A;  3OK8 A;  3QE6 A;  2X3W A;  1I4L A;  2RAI A;  2Z0O A;  4DYL A;  2C08 A;  2EFL A;  3CAZ A;  3M3W A;  3PLT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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