2Z0NA

Crystal structure of appl1-bar domain
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
243
structure length
235
Chain Sequence
LEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of APPL1-BAR domain
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords DCC-interacting protein 13-alpha
total genus 94
structure length 235
sequence length 243
ec nomenclature
pdb deposition date 2007-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16746 BAR_3 BAR domain of APPL family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1270.60 Mainly Alpha Up-down Bundle Substrate Binding Domain Of Dnak; Chain:A; Domain 2 Arfaptin homology (AH) domain/BAR domain 2z0nA00
3QWEA 4FZSA 2Q13A 1I4TA 1X04A 2RAJA 3HAIA 3HAJA 3Q84A 2ELBA 5C5BB 2EFLA 2D4CA 4H8SA 1I49A 2V0OA 3SYVA 4WPEA 1URUA 1X03A 2C08A 3OK8A 1I4DA 2X3WA 3G9GA 3I2WA 4NSWA 3DYTA 4ATMA 3Q0KA 3QNIA 1WDZA 2EFKA 3ABHA 3QE6A 1ZWWA 2X3XA 4DYLA 5C5BA 3HAHA 2Z0OA 3ACOA 4DCNC 4BNEA 3M3WA 2Q12A 2YKTA 3SOGA 4NQIA 2D1LA 4AVMA 2RAIA 2X3VA 1Y2OA 3PLTA 2FICA 2RAKA 2Z0VA 1I4LA 2Z0NA 3CAZA 3LLLA 4I1QA 4AKVA 4WPCA
chains in the Genus database with same CATH superfamily
2PY6A 2RAJA 3ER9B 3D52A 3ZEDA 1I49A 3LVTA 2JNKA 3DDFA 2YLLA 1DKYA 4DYLA 1GNLA 4EZZA 2QKWA 4BNEA 3ERCC 4F00A 3PLTA 1Y2OA 2YI9A 3UITA 3CZNA 2GF4A 2Q13A 4JNFA 5FIGA 3B53X 2D4CA 3BUIA 2FYVA 1TQSA 4EZVA 1YWMA 3RV1A 4AVMA 4JWDA 4JN4A 4D8JA 1X04A 3EJSA 1OAOA 1DKZA 2Z8YA 4FZOA 3OK8A 1TQUA 4AZ7A 1R34A 3CZSA 3T49A 3BUDA 3EJPA 1GN9A 2YIVX 2V0OA 3SYVA 5TKYA 1URUA 3CV5A 4G6QA 1TQWA 3RPMA 4AZ5A 4EZTA 3QE6A 3KAWA 3DDGA 3HAHA 3FD9A 3KDRA 3ACOA 2ND1A 2OZNB 4R5JA 4JWIA 3DX0A 4M0MA 5KBPA 2ZXQA 2EWFA 4AZCB 3DPOA 3F7WA 2KHOA 4HY9A 4IWQA 2N3KA 1E9VA 1O7DB 1QWUA 3T47A 2O0I1 4NPHA 4AZ6A 2YIAA 1WDZA 3QNJA 2LM0A 1HTYA 4PO2A 1HWWA 4EZWA 2ELBA 4KIKB 3BLBA 4EZPA 3G9GA 3I39X 4IM3A 2F18A 3ABHA 4H6HA 1SU6A 2FICA 2PMRA 3GI7A 4AKVA 4FZSA 3BVTA 4IWPA 1UPXA 5C5BB 4H8SA 3DX2A 3CKDA 3A98A 4JWEA 2YLAA 1DKXA 2YL8A 3QA8A 5E84A 2X5CA 2Z0VA 1R33A 3CAZA 2F1BA 1GNTA 3QWEA 1SU8A 3D51A 3D4YA 3Q84A 4EZNA 3T46A 2F1AA 4E81A 4JL9A 4NSWA 2GAFD 3T48A 2F7PA 2GA9D 3VKHA 1MJGA 2YKTA 3B51X 4EZQA 3LLLA 2LXYA 3BVWA 1E2UA 1SUFA 4HR1B 2WINM 1JQKA 4JWCA 4KIKA 2ND0A 4NQIA 1QWNA 4EZYA 3O3MB 2RAKA 2Z0NA 2JNSA 4JNEA 3HAJA 3HAIA 2QFFA 1TQTA 2OBLA 4EZSA 4R5IA 3OWGA 4F01A 3DYTA 2WYIA 4IW0A 3Q0KA 4EZXA 5C5BA 1HXKA 1ZYLA 3ER8C 3EJQA 2MI7A 2D1LA 4H6IA 1PS3A 2EX3B 3KAVA 2YI8A 3D50A 4WPCA 4B9QA 1I4TA 4IWOA 3DX3A 4UDXX 1QX1A 3BUQA 1OA0A 1ZWWA 4IM0A 3EJRA 4DCNC 2YL6A 3M3WA 2Q12A 3SOGA 4JLCA 2X3VA 3VEAA 3B52X 1I4LA 3BVXA 1TQVA 3BUBA 2ALWA 2EFLA 2F7OA 2C08A 3D2EA 4R5GA 2X3WA 4IM2A 4HR1A 4HYBA 2OBMA 2WYHA 1SU7A 3L3OM 3T4AG 1W9MA 3C7NA 4R5KA 3BUPA 4AZCA 4FM3A 1R5EA 2QXLA 1I4DA 3I2WA 3OHXM 2RT6A 4UDYX 2Z0OA 2YL9A 4EZUA 1LQ7A 3RV0A 3BVVA 4EZRA 2F7RA 4AZGA 3CVRA 3I01A 3LMFA 3I04A 2OO2A 2YL5A 4WPEA 1OA1A 3DPQA 2F7QA 4AZHA 3D2FA 5FLEX 4ATMA 3QNIA 2EFKA 4R5LA 3BVUA 3VEBA 2NCZA 4EZOA 2OW7A 3EJTA 2RAIA 3DX1A 3DPPA 3EJUA 2OW6A 4I1QA 3DX4A 1O7DC 3D4ZA 1E1DA 2YIBA 4AZBA 1X03A 4FZPA 2X3XA 4E3CA 3O3OB 3L3PA 1U00A 4AZIA 3O3NB
chains in the Genus database with same CATH topology
3QWEA 4FZSA 2Q13A 1I4TA 1X04A 2RAJA 3HAIA 3HAJA 3Q84A 2ELBA 5C5BB 2EFLA 2D4CA 4H8SA 1I49A 2V0OA 3SYVA 4WPEA 1URUA 1X03A 2C08A 3OK8A 1I4DA 2X3WA 3G9GA 3I2WA 4NSWA 3DYTA 4ATMA 3Q0KA 3QNIA 1WDZA 2EFKA 3ABHA 3QE6A 1ZWWA 2X3XA 4DYLA 5C5BA 3HAHA 2Z0OA 3ACOA 4DCNC 4BNEA 3M3WA 2Q12A 2YKTA 3SOGA 4NQIA 2D1LA 4AVMA 2RAIA 2X3VA 1Y2OA 3PLTA 2FICA 2RAKA 2Z0VA 1I4LA 2Z0NA 3CAZA 3LLLA 4I1QA 4AKVA 4WPCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QWE A;  4FZS A;  2Q13 A;  1I4T A;  1X04 A;  2RAJ A;  3HAI A;  3HAJ A;  3Q84 A;  2ELB A;  5C5B B;  2EFL A;  2D4C A;  4H8S A;  1I49 A;  2V0O A;  3SYV A;  4WPE A;  1URU A;  1X03 A;  2C08 A;  3OK8 A;  1I4D A;  2X3W A;  3G9G A;  3I2W A;  4NSW A;  3DYT A;  4ATM A;  3Q0K A;  3QNI A;  1WDZ A;  2EFK A;  3ABH A;  3QE6 A;  1ZWW A;  2X3X A;  4DYL A;  5C5B A;  3HAH A;  2Z0O A;  3ACO A;  4DCN C;  4BNE A;  3M3W A;  2Q12 A;  2YKT A;  3SOG A;  4NQI A;  2D1L A;  4AVM A;  2RAI A;  2X3V A;  1Y2O A;  3PLT A;  2FIC A;  2RAK A;  2Z0V A;  1I4L A;  2Z0N A;  3CAZ A;  3LLL A;  4I1Q A;  4AKV A;  4WPC A; 
#chains in the Genus database with same CATH topology
 2PY6 A;  2RAJ A;  3ER9 B;  3D52 A;  3ZED A;  1I49 A;  3LVT A;  2JNK A;  3DDF A;  2YLL A;  1DKY A;  4DYL A;  1GNL A;  4EZZ A;  2QKW A;  4BNE A;  3ERC C;  4F00 A;  3PLT A;  1Y2O A;  2YI9 A;  3UIT A;  3CZN A;  2GF4 A;  2Q13 A;  4JNF A;  5FIG A;  3B53 X;  2D4C A;  3BUI A;  2FYV A;  1TQS A;  4EZV A;  1YWM A;  3RV1 A;  4AVM A;  4JWD A;  4JN4 A;  4D8J A;  1X04 A;  3EJS A;  1OAO A;  1DKZ A;  2Z8Y A;  4FZO A;  3OK8 A;  1TQU A;  4AZ7 A;  1R34 A;  3CZS A;  3T49 A;  3BUD A;  3EJP A;  1GN9 A;  2YIV X;  2V0O A;  3SYV A;  5TKY A;  1URU A;  3CV5 A;  4G6Q A;  1TQW A;  3RPM A;  4AZ5 A;  4EZT A;  3QE6 A;  3KAW A;  3DDG A;  3HAH A;  3FD9 A;  3KDR A;  3ACO A;  2ND1 A;  2OZN B;  4R5J A;  4JWI A;  3DX0 A;  4M0M A;  5KBP A;  2ZXQ A;  2EWF A;  4AZC B;  3DPO A;  3F7W A;  2KHO A;  4HY9 A;  4IWQ A;  2N3K A;  1E9V A;  1O7D B;  1QWU A;  3T47 A;  2O0I 1;  4NPH A;  4AZ6 A;  2YIA A;  1WDZ A;  3QNJ A;  2LM0 A;  1HTY A;  4PO2 A;  1HWW A;  4EZW A;  2ELB A;  4KIK B;  3BLB A;  4EZP A;  3G9G A;  3I39 X;  4IM3 A;  2F18 A;  3ABH A;  4H6H A;  1SU6 A;  2FIC A;  2PMR A;  3GI7 A;  4AKV A;  4FZS A;  3BVT A;  4IWP A;  1UPX A;  5C5B B;  4H8S A;  3DX2 A;  3CKD A;  3A98 A;  4JWE A;  2YLA A;  1DKX A;  2YL8 A;  3QA8 A;  5E84 A;  2X5C A;  2Z0V A;  1R33 A;  3CAZ A;  2F1B A;  1GNT A;  3QWE A;  1SU8 A;  3D51 A;  3D4Y A;  3Q84 A;  4EZN A;  3T46 A;  2F1A A;  4E81 A;  4JL9 A;  4NSW A;  2GAF D;  3T48 A;  2F7P A;  2GA9 D;  3VKH A;  1MJG A;  2YKT A;  3B51 X;  4EZQ A;  3LLL A;  2LXY A;  3BVW A;  1E2U A;  1SUF A;  4HR1 B;  2WIN M;  1JQK A;  4JWC A;  4KIK A;  2ND0 A;  4NQI A;  1QWN A;  4EZY A;  3O3M B;  2RAK A;  2Z0N A;  2JNS A;  4JNE A;  3HAJ A;  3HAI A;  2QFF A;  1TQT A;  2OBL A;  4EZS A;  4R5I A;  3OWG A;  4F01 A;  3DYT A;  2WYI A;  4IW0 A;  3Q0K A;  4EZX A;  5C5B A;  1HXK A;  1ZYL A;  3ER8 C;  3EJQ A;  2MI7 A;  2D1L A;  4H6I A;  1PS3 A;  2EX3 B;  3KAV A;  2YI8 A;  3D50 A;  4WPC A;  4B9Q A;  1I4T A;  4IWO A;  3DX3 A;  4UDX X;  1QX1 A;  3BUQ A;  1OA0 A;  1ZWW A;  4IM0 A;  3EJR A;  4DCN C;  2YL6 A;  3M3W A;  2Q12 A;  3SOG A;  4JLC A;  2X3V A;  3VEA A;  3B52 X;  1I4L A;  3BVX A;  1TQV A;  3BUB A;  2ALW A;  2EFL A;  2F7O A;  2C08 A;  3D2E A;  4R5G A;  2X3W A;  4IM2 A;  4HR1 A;  4HYB A;  2OBM A;  2WYH A;  1SU7 A;  3L3O M;  3T4A G;  1W9M A;  3C7N A;  4R5K A;  3BUP A;  4AZC A;  4FM3 A;  1R5E A;  2QXL A;  1I4D A;  3I2W A;  3OHX M;  2RT6 A;  4UDY X;  2Z0O A;  2YL9 A;  4EZU A;  1LQ7 A;  3RV0 A;  3BVV A;  4EZR A;  2F7R A;  4AZG A;  3CVR A;  3I01 A;  3LMF A;  3I04 A;  2OO2 A;  2YL5 A;  4WPE A;  1OA1 A;  3DPQ A;  2F7Q A;  4AZH A;  3D2F A;  5FLE X;  4ATM A;  3QNI A;  2EFK A;  4R5L A;  3BVU A;  3VEB A;  2NCZ A;  4EZO A;  2OW7 A;  3EJT A;  2RAI A;  3DX1 A;  3DPP A;  3EJU A;  2OW6 A;  4I1Q A;  3DX4 A;  1O7D C;  3D4Z A;  1E1D A;  2YIB A;  4AZB A;  1X03 A;  4FZP A;  2X3X A;  4E3C A;  3O3O B;  3L3P A;  1U00 A;  4AZI A;  3O3N B; 
#chains in the Genus database with same CATH homology
 3QWE A;  4FZS A;  2Q13 A;  1I4T A;  1X04 A;  2RAJ A;  3HAI A;  3HAJ A;  3Q84 A;  2ELB A;  5C5B B;  2EFL A;  2D4C A;  4H8S A;  1I49 A;  2V0O A;  3SYV A;  4WPE A;  1URU A;  1X03 A;  2C08 A;  3OK8 A;  1I4D A;  2X3W A;  3G9G A;  3I2W A;  4NSW A;  3DYT A;  4ATM A;  3Q0K A;  3QNI A;  1WDZ A;  2EFK A;  3ABH A;  3QE6 A;  1ZWW A;  2X3X A;  4DYL A;  5C5B A;  3HAH A;  2Z0O A;  3ACO A;  4DCN C;  4BNE A;  3M3W A;  2Q12 A;  2YKT A;  3SOG A;  4NQI A;  2D1L A;  4AVM A;  2RAI A;  2X3V A;  1Y2O A;  3PLT A;  2FIC A;  2RAK A;  2Z0V A;  1I4L A;  2Z0N A;  3CAZ A;  3LLL A;  4I1Q A;  4AKV A;  4WPC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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