4CFXB

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.
Total Genus 95

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
260
structure length
260
Chain Sequence
NEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
AH1 (178-193)AH2 (198-202)AH5 (253-268)EMPTYAH3 (208-225)TI1 (203-206)3H1 (250-252)AH4 (229-244)Updating...
connected with : NaN
molecule tags Cell cycle
source organism Homo sapiens
publication title 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
pubmed doi rcsb
molecule keywords CYCLIN-DEPENDENT KINASE 2
total genus 95
structure length 260
sequence length 260
chains with identical sequence D
ec nomenclature
pdb deposition date 2013-11-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00134 Cyclin_N Cyclin, N-terminal domain
B PF02984 Cyclin_C Cyclin, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 4cfxB01
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 4cfxB02
4BCFB 4KRCB 4BCOB 3QHRB 5EFQB 4EC8B 3MIAB 4EORB 4F7JB 2WMBB 3TNWB 5IF1B 3QHWB 1C9BA 1O9KA 2G9XB 3MI9B 1FVVB 2B9RA 2JGZB 3MY5B 4BCNB 1G3NC 5HQ0B 1H4LD 1UNLD 2WXVB 1FINB 3EIDB 4OGRB 4EOKB 1D3UB 3MY1B 1GUXA 4CFMB 2QDJA 5BNJB 5L2WB 1UNHD 4EC9B 5CEIB 2EUFA 2UUEB 4BCMD 4CXAB 4EOOB 4BCIB 1ZP2A 4ELLA 2UZLB 2WMAB 5I5ZB 3BLHB 5FGKB 4BCPB 2C5XB 5IDNB 5ICPB 1H26B 2PMIB 4F6WB 1URCB 1OIYB 4BCHB 4ROCA 1UNGD 4F7NB 1OI9B 2V22B 2BKZB 5LMKB 4BCQD 2C5VB 1XO2A 2CCHB 2PK9B 1VYWB 2W9FA 4F7LB 2IVXA 2F2CA 1H28B 2I53A 2IW6B 2X1NB 1VINA 4CFNB 4CFUD 1KXUA 4OR5B 1W98B 4CFVB 3EOCB 4II5B 2W96A 1N4MA 4YC3B 5ACBA 4ELJA 1VOLA 3LQ5B 4CFXB 5HNBB 3K7AM 1AD6A 4CRLB 5HBEB 1F5QB 4ROEA 4EOIB 4BCJB 4EOLB 3TN8B 2IW9B 3G33B 4EONB 1JOWA 3BHVB 3H4CA 2CJMB 4F6UB 1PKDB 4F6SB 2UZDB 3TNIB 4IMYB 1JSUB 3BHUB 4BCND 5IDPB 4YOZA 3DDQB 4RODA 2WHBB 1H24B 1H1PB 2C5OB 1H25B 2PK2A 1AISB 2CCIB 4EOSB 2W2HA 4G6LB 1OL2B 3BLRB 1OL1B 1JKWA 5LQFB 2UZBB 2WIPB 4BCMB 1H27B 1JSTB 1QMZB 4F70B 2W9ZA 4EOPB 1OGUB 2W99A 2IW8B 2C4GB 1GY3B 2PHGA 4BCKB 1OKVB 4CFWB 4EOMB 1P5EB 3EJ1B 1OKWB 2C5NB 4NSTB 5HBJB 4YOSA 2UZEB 2WEVB 2WFYB 5HBHB 3TNHB 4EOQB 1E9HB 4EOJB 4F7SB 4BCGB 4YOOA 5HVYB 2WPAB 1TFBA 3F5XB 4UN0A 4BCQB 1H1SB 4FX3B 1H1RB 2WIHB 2I40B 1GH6B 3DOGB 3M03A 3BHTB 3POMA 2R7GA 1BU2A 4CFUB 5CYIB 1O9KB 4KRDB 4Y72B 1H1QB 4TTHA 4I3ZB 3BLQB 3DDPB 2C6TB 1OIUB 2BPMB 3O0GD 1GUXB 3RGFB
chains in the Genus database with same CATH superfamily
4BCFB 3MIAB 2ZPEB 1TD6A 3DL1A 3TNWB 5IF1B 4AI6A 1FVVB 3KHIA 3QYGB 1H4LD 3EIDB 3GTMS 4EOKB 1D3UB 4BY1X 4CFMB 2DPPB 1IREB 2C5XB 3QZ5B 5ICPB 2PMIB 4F6WB 1OIYB 4F7NB 2AHJB 1UGQB 1XO2A 2W9FA 4OB3B 3VKHA 1H28B 2I53A 4MFEA 1VINA 4CFUD 1KXUA 1UGRB 2BS4A 2W96A 4HLQA 3TW7A 4ELJA 1AD6A 4CRLB 3BG9A 1F5QB 3G33B 4EONB 2CJMB 1PKDB 2WHBB 1H25B 1AISB 4AKIA 1OL1B 1JKWA 4ZGDB 2UZBB 1JSTB 1QMZB 4F70B 4BCKB 1GY3B 3VYHB 2DMEA 3DTOA 2WFYB 3QYBA 5HBHB 4EOQB 1ENWA 4EOJB 2G77A 4YOOA 1H1RB 4Z6YA 2I40B 3POMA 3QXEB 3QZ9B 2WJ9A 4CFUB 2ZCFB 2KMGA 4I3ZB 2BPMB 2DXBB 4EORB 4AKGA 3VKGA 1C9BA 3HHTB 2CYZB 5HQ0B 2WXVB 5EJCA 5BNJB 1UNHD 2EUFA 4BCMD 4CXAB 4AKHA 4ZGJB 3BLHB 4BCPB 2ZZDB 3NDQA 4ROCA 1UNGD 2QDYB 2BKZB 3A8LB 3X28B 2CCHB 1VYWB 2IVXA 4OB2B 4CFNB 1N4MA 4CFXB 4ROEA 4EOLB 1E7PA 4HL4A 3BHVB 3H4CA 2UZDB 1FKMA 4BCND 5IDPB 4YOZA 4JX5A 1H24B 1H1PB 4G6LB 1OL2B 2ZPGB 1H27B 4BCMB 2W9ZA 1OGUB 2W99A 2PHGA 3B57A 4BY7X 1P5EB 3EJ1B 1OKWB 2LW4A 2IN3A 3HB9A 3WVDB 3TNHB 4F7SB 1E9HB 3X24B 1UGPB 2WPAB 4FX3B 4M6VA 3M03A 2QGSA 1BU2A 5CYIB 2CZ7B 3A8HB 4KRDB 4LOCA 2ZPHB 4MFDA 3HO8A 3RGFB 4EC8B 1O9KA 2B9RA 2JGZB 3MY5B 4BCNB 4OB1B 4MIMA 4OGRB 4HNTA 2QQ8A 1GUXA 2QDJA 5L2WB 4EC9B 2ZPIB 4NC6A 1ZP2A 2WMAB 1QLBA 5IDNB 1H26B 1URCB 4BCHB 2ZPBB 2BS3A 5LMKB 4BCQD 2C5VB 3PO3S 2F2CA 3BG3A 2QF7A 3VYGB 2X1NB 5DQVA 3DJBA 1AHJB 4HNVA 3EOCB 1VOLA 5HNBB 3A8GB 3QYHB 2IW9B 4F6SB 3TNIB 4IMYB 4RODA 2CZ0B 2CCIB 3X25B 4EOSB 4BBRM 2W2HA 3BLRB 2DD4B 5LQFB 3X20B 4EOPB 3HZJA 2IW8B 4CFWB 1OKVB 2DXCB 2C5NB 4BXXX 2UZEB 1TFBA 3F5XB 3BG5A 4UN0A 4BCQB 3DOGB 1GH6B 4JX4A 3BHTB 3QYEA 1O9KB 1H1QB 1UGSB 2QFZA 3DDPB 1OIUB 3HBLA 3O0GD 1GUXB 2CZ1B 3A8OB 4KRCB 4BCOB 3QHRB 5EFQB 4ZGEB 4F7JB 2WMBB 3QHWB 2BS2A 2G9XB 3WVEB 3MI9B 2CZ6B 2KR6A 1G3NC 3X26B 1UNLD 1FINB 2D0QB 3MY1B 5CEIB 2UUEB 2DD5B 4FM4B 2ZPFB 4QSHA 4EOOB 3A8MB 4BCIB 4ELLA 2UZLB 5I5ZB 5FGKB 4JX6A 5IHYA 1OI9B 2V22B 2PK9B 4F7LB 4OB0B 2IW6B 4OR5B 1W98B 4CFVB 4II5B 4HNUA 4YC3B 5ACBA 3LQ5B 3K7AM 5HBEB 4EOIB 4BCJB 3TN8B 1JOWA 4F6UB 1JSUB 3BHUB 3DDQB 2C5OB 2PK2A 4BBSM 2PJQA 1V29B 2WIPB 2C4GB 4EOMB 4NSTB 5HBJB 4YOSA 2WEVB 4BCGB 5HVYB 3QWLA 1H1SB 2WIHB 5DQWA 2R7GA 3TW6A 4Y72B 4TTHA 3BLQB 2C6TB
chains in the Genus database with same CATH topology
4BCFB 4KRCB 4BCOB 3QHRB 5EFQB 4EC8B 3MIAB 4EORB 4F7JB 2WMBB 3TNWB 5IF1B 3QHWB 1C9BA 1O9KA 2G9XB 3MI9B 1FVVB 2B9RA 2JGZB 3MY5B 4BCNB 1G3NC 5HQ0B 1H4LD 1UNLD 2WXVB 1FINB 3EIDB 4OGRB 4EOKB 1D3UB 3MY1B 1GUXA 4CFMB 2QDJA 5BNJB 5L2WB 1UNHD 4EC9B 5CEIB 2EUFA 2UUEB 4BCMD 4CXAB 4EOOB 4BCIB 1ZP2A 4ELLA 2UZLB 2WMAB 5I5ZB 3BLHB 5FGKB 4BCPB 2C5XB 5IDNB 5ICPB 1H26B 2PMIB 4F6WB 1URCB 1OIYB 4BCHB 4ROCA 1UNGD 4F7NB 1OI9B 2V22B 2BKZB 5LMKB 4BCQD 2C5VB 1XO2A 2CCHB 2PK9B 1VYWB 2W9FA 4F7LB 2IVXA 2F2CA 1H28B 2I53A 2IW6B 2X1NB 1VINA 4CFNB 4CFUD 1KXUA 4OR5B 1W98B 4CFVB 3EOCB 4II5B 2W96A 1N4MA 4YC3B 5ACBA 4ELJA 1VOLA 3LQ5B 4CFXB 5HNBB 3K7AM 1AD6A 4CRLB 5HBEB 1F5QB 4ROEA 4EOIB 4BCJB 4EOLB 3TN8B 2IW9B 3G33B 4EONB 1JOWA 3BHVB 3H4CA 2CJMB 4F6UB 1PKDB 4F6SB 2UZDB 3TNIB 4IMYB 1JSUB 3BHUB 4BCND 5IDPB 4YOZA 3DDQB 4RODA 2WHBB 1H24B 1H1PB 2C5OB 1H25B 2PK2A 1AISB 2CCIB 4EOSB 2W2HA 4G6LB 1OL2B 3BLRB 1OL1B 1JKWA 5LQFB 2UZBB 2WIPB 4BCMB 1H27B 1JSTB 1QMZB 4F70B 2W9ZA 4EOPB 1OGUB 2W99A 2IW8B 2C4GB 1GY3B 2PHGA 4BCKB 1OKVB 4CFWB 4EOMB 1P5EB 3EJ1B 1OKWB 2C5NB 4NSTB 5HBJB 4YOSA 2UZEB 2WEVB 2WFYB 5HBHB 3TNHB 4EOQB 1E9HB 4EOJB 4F7SB 4BCGB 4YOOA 5HVYB 2WPAB 1TFBA 3F5XB 4UN0A 4BCQB 1H1SB 4FX3B 1H1RB 2WIHB 2I40B 1GH6B 3DOGB 3M03A 3BHTB 3POMA 2R7GA 1BU2A 4CFUB 5CYIB 1O9KB 4KRDB 4Y72B 1H1QB 4TTHA 4I3ZB 3BLQB 3DDPB 2C6TB 1OIUB 2BPMB 3O0GD 1GUXB 3RGFB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4BCF B;  4KRC B;  4BCO B;  3QHR B;  5EFQ B;  4EC8 B;  3MIA B;  4EOR B;  4F7J B;  2WMB B;  3TNW B;  5IF1 B;  3QHW B;  1C9B A;  1O9K A;  2G9X B;  3MI9 B;  1FVV B;  2B9R A;  2JGZ B;  3MY5 B;  4BCN B;  1G3N C;  5HQ0 B;  1H4L D;  1UNL D;  2WXV B;  1FIN B;  3EID B;  4OGR B;  4EOK B;  1D3U B;  3MY1 B;  1GUX A;  4CFM B;  2QDJ A;  5BNJ B;  5L2W B;  1UNH D;  4EC9 B;  5CEI B;  2EUF A;  2UUE B;  4BCM D;  4CXA B;  4EOO B;  4BCI B;  1ZP2 A;  4ELL A;  2UZL B;  2WMA B;  5I5Z B;  3BLH B;  5FGK B;  4BCP B;  2C5X B;  5IDN B;  5ICP B;  1H26 B;  2PMI B;  4F6W B;  1URC B;  1OIY B;  4BCH B;  4ROC A;  1UNG D;  4F7N B;  1OI9 B;  2V22 B;  2BKZ B;  5LMK B;  4BCQ D;  2C5V B;  1XO2 A;  2CCH B;  2PK9 B;  1VYW B;  2W9F A;  4F7L B;  2IVX A;  2F2C A;  1H28 B;  2I53 A;  2IW6 B;  2X1N B;  1VIN A;  4CFN B;  4CFU D;  1KXU A;  4OR5 B;  1W98 B;  4CFV B;  3EOC B;  4II5 B;  2W96 A;  1N4M A;  4YC3 B;  5ACB A;  4ELJ A;  1VOL A;  3LQ5 B;  4CFX B;  5HNB B;  3K7A M;  1AD6 A;  4CRL B;  5HBE B;  1F5Q B;  4ROE A;  4EOI B;  4BCJ B;  4EOL B;  3TN8 B;  2IW9 B;  3G33 B;  4EON B;  1JOW A;  3BHV B;  3H4C A;  2CJM B;  4F6U B;  1PKD B;  4F6S B;  2UZD B;  3TNI B;  4IMY B;  1JSU B;  3BHU B;  4BCN D;  5IDP B;  4YOZ A;  3DDQ B;  4ROD A;  2WHB B;  1H24 B;  1H1P B;  2C5O B;  1H25 B;  2PK2 A;  1AIS B;  2CCI B;  4EOS B;  2W2H A;  4G6L B;  1OL2 B;  3BLR B;  1OL1 B;  1JKW A;  5LQF B;  2UZB B;  2WIP B;  4BCM B;  1H27 B;  1JST B;  1QMZ B;  4F70 B;  2W9Z A;  4EOP B;  1OGU B;  2W99 A;  2IW8 B;  2C4G B;  1GY3 B;  2PHG A;  4BCK B;  1OKV B;  4CFW B;  4EOM B;  1P5E B;  3EJ1 B;  1OKW B;  2C5N B;  4NST B;  5HBJ B;  4YOS A;  2UZE B;  2WEV B;  2WFY B;  5HBH B;  3TNH B;  4EOQ B;  1E9H B;  4EOJ B;  4F7S B;  4BCG B;  4YOO A;  5HVY B;  2WPA B;  1TFB A;  3F5X B;  4UN0 A;  4BCQ B;  1H1S B;  4FX3 B;  1H1R B;  2WIH B;  2I40 B;  1GH6 B;  3DOG B;  3M03 A;  3BHT B;  3POM A;  2R7G A;  1BU2 A;  4CFU B;  5CYI B;  1O9K B;  4KRD B;  4Y72 B;  1H1Q B;  4TTH A;  4I3Z B;  3BLQ B;  3DDP B;  2C6T B;  1OIU B;  2BPM B;  3O0G D;  1GUX B;  3RGF B; 
#chains in the Genus database with same CATH topology
 4BCF B;  3MIA B;  2ZPE B;  1TD6 A;  3DL1 A;  3TNW B;  5IF1 B;  4AI6 A;  1FVV B;  3KHI A;  3QYG B;  1H4L D;  3EID B;  3GTM S;  4EOK B;  1D3U B;  4BY1 X;  4CFM B;  2DPP B;  1IRE B;  2C5X B;  3QZ5 B;  5ICP B;  2PMI B;  4F6W B;  1OIY B;  4F7N B;  2AHJ B;  1UGQ B;  1XO2 A;  2W9F A;  4OB3 B;  3VKH A;  1H28 B;  2I53 A;  4MFE A;  1VIN A;  4CFU D;  1KXU A;  1UGR B;  2BS4 A;  2W96 A;  4HLQ A;  3TW7 A;  4ELJ A;  1AD6 A;  4CRL B;  3BG9 A;  1F5Q B;  3G33 B;  4EON B;  2CJM B;  1PKD B;  2WHB B;  1H25 B;  1AIS B;  4AKI A;  1OL1 B;  1JKW A;  4ZGD B;  2UZB B;  1JST B;  1QMZ B;  4F70 B;  4BCK B;  1GY3 B;  3VYH B;  2DME A;  3DTO A;  2WFY B;  3QYB A;  5HBH B;  4EOQ B;  1ENW A;  4EOJ B;  2G77 A;  4YOO A;  1H1R B;  4Z6Y A;  2I40 B;  3POM A;  3QXE B;  3QZ9 B;  2WJ9 A;  4CFU B;  2ZCF B;  2KMG A;  4I3Z B;  2BPM B;  2DXB B;  4EOR B;  4AKG A;  3VKG A;  1C9B A;  3HHT B;  2CYZ B;  5HQ0 B;  2WXV B;  5EJC A;  5BNJ B;  1UNH D;  2EUF A;  4BCM D;  4CXA B;  4AKH A;  4ZGJ B;  3BLH B;  4BCP B;  2ZZD B;  3NDQ A;  4ROC A;  1UNG D;  2QDY B;  2BKZ B;  3A8L B;  3X28 B;  2CCH B;  1VYW B;  2IVX A;  4OB2 B;  4CFN B;  1N4M A;  4CFX B;  4ROE A;  4EOL B;  1E7P A;  4HL4 A;  3BHV B;  3H4C A;  2UZD B;  1FKM A;  4BCN D;  5IDP B;  4YOZ A;  4JX5 A;  1H24 B;  1H1P B;  4G6L B;  1OL2 B;  2ZPG B;  1H27 B;  4BCM B;  2W9Z A;  1OGU B;  2W99 A;  2PHG A;  3B57 A;  4BY7 X;  1P5E B;  3EJ1 B;  1OKW B;  2LW4 A;  2IN3 A;  3HB9 A;  3WVD B;  3TNH B;  4F7S B;  1E9H B;  3X24 B;  1UGP B;  2WPA B;  4FX3 B;  4M6V A;  3M03 A;  2QGS A;  1BU2 A;  5CYI B;  2CZ7 B;  3A8H B;  4KRD B;  4LOC A;  2ZPH B;  4MFD A;  3HO8 A;  3RGF B;  4EC8 B;  1O9K A;  2B9R A;  2JGZ B;  3MY5 B;  4BCN B;  4OB1 B;  4MIM A;  4OGR B;  4HNT A;  2QQ8 A;  1GUX A;  2QDJ A;  5L2W B;  4EC9 B;  2ZPI B;  4NC6 A;  1ZP2 A;  2WMA B;  1QLB A;  5IDN B;  1H26 B;  1URC B;  4BCH B;  2ZPB B;  2BS3 A;  5LMK B;  4BCQ D;  2C5V B;  3PO3 S;  2F2C A;  3BG3 A;  2QF7 A;  3VYG B;  2X1N B;  5DQV A;  3DJB A;  1AHJ B;  4HNV A;  3EOC B;  1VOL A;  5HNB B;  3A8G B;  3QYH B;  2IW9 B;  4F6S B;  3TNI B;  4IMY B;  4ROD A;  2CZ0 B;  2CCI B;  3X25 B;  4EOS B;  4BBR M;  2W2H A;  3BLR B;  2DD4 B;  5LQF B;  3X20 B;  4EOP B;  3HZJ A;  2IW8 B;  4CFW B;  1OKV B;  2DXC B;  2C5N B;  4BXX X;  2UZE B;  1TFB A;  3F5X B;  3BG5 A;  4UN0 A;  4BCQ B;  3DOG B;  1GH6 B;  4JX4 A;  3BHT B;  3QYE A;  1O9K B;  1H1Q B;  1UGS B;  2QFZ A;  3DDP B;  1OIU B;  3HBL A;  3O0G D;  1GUX B;  2CZ1 B;  3A8O B;  4KRC B;  4BCO B;  3QHR B;  5EFQ B;  4ZGE B;  4F7J B;  2WMB B;  3QHW B;  2BS2 A;  2G9X B;  3WVE B;  3MI9 B;  2CZ6 B;  2KR6 A;  1G3N C;  3X26 B;  1UNL D;  1FIN B;  2D0Q B;  3MY1 B;  5CEI B;  2UUE B;  2DD5 B;  4FM4 B;  2ZPF B;  4QSH A;  4EOO B;  3A8M B;  4BCI B;  4ELL A;  2UZL B;  5I5Z B;  5FGK B;  4JX6 A;  5IHY A;  1OI9 B;  2V22 B;  2PK9 B;  4F7L B;  4OB0 B;  2IW6 B;  4OR5 B;  1W98 B;  4CFV B;  4II5 B;  4HNU A;  4YC3 B;  5ACB A;  3LQ5 B;  3K7A M;  5HBE B;  4EOI B;  4BCJ B;  3TN8 B;  1JOW A;  4F6U B;  1JSU B;  3BHU B;  3DDQ B;  2C5O B;  2PK2 A;  4BBS M;  2PJQ A;  1V29 B;  2WIP B;  2C4G B;  4EOM B;  4NST B;  5HBJ B;  4YOS A;  2WEV B;  4BCG B;  5HVY B;  3QWL A;  1H1S B;  2WIH B;  5DQW A;  2R7G A;  3TW6 A;  4Y72 B;  4TTH A;  3BLQ B;  2C6T B; 
#chains in the Genus database with same CATH homology
 4BCF B;  4KRC B;  4BCO B;  3QHR B;  5EFQ B;  4EC8 B;  3MIA B;  4EOR B;  4F7J B;  2WMB B;  3TNW B;  5IF1 B;  3QHW B;  1C9B A;  1O9K A;  2G9X B;  3MI9 B;  1FVV B;  2B9R A;  2JGZ B;  3MY5 B;  4BCN B;  1G3N C;  5HQ0 B;  1H4L D;  1UNL D;  2WXV B;  1FIN B;  3EID B;  4OGR B;  4EOK B;  1D3U B;  3MY1 B;  1GUX A;  4CFM B;  2QDJ A;  5BNJ B;  5L2W B;  1UNH D;  4EC9 B;  5CEI B;  2EUF A;  2UUE B;  4BCM D;  4CXA B;  4EOO B;  4BCI B;  1ZP2 A;  4ELL A;  2UZL B;  2WMA B;  5I5Z B;  3BLH B;  5FGK B;  4BCP B;  2C5X B;  5IDN B;  5ICP B;  1H26 B;  2PMI B;  4F6W B;  1URC B;  1OIY B;  4BCH B;  4ROC A;  1UNG D;  4F7N B;  1OI9 B;  2V22 B;  2BKZ B;  5LMK B;  4BCQ D;  2C5V B;  1XO2 A;  2CCH B;  2PK9 B;  1VYW B;  2W9F A;  4F7L B;  2IVX A;  2F2C A;  1H28 B;  2I53 A;  2IW6 B;  2X1N B;  1VIN A;  4CFN B;  4CFU D;  1KXU A;  4OR5 B;  1W98 B;  4CFV B;  3EOC B;  4II5 B;  2W96 A;  1N4M A;  4YC3 B;  5ACB A;  4ELJ A;  1VOL A;  3LQ5 B;  4CFX B;  5HNB B;  3K7A M;  1AD6 A;  4CRL B;  5HBE B;  1F5Q B;  4ROE A;  4EOI B;  4BCJ B;  4EOL B;  3TN8 B;  2IW9 B;  3G33 B;  4EON B;  1JOW A;  3BHV B;  3H4C A;  2CJM B;  4F6U B;  1PKD B;  4F6S B;  2UZD B;  3TNI B;  4IMY B;  1JSU B;  3BHU B;  4BCN D;  5IDP B;  4YOZ A;  3DDQ B;  4ROD A;  2WHB B;  1H24 B;  1H1P B;  2C5O B;  1H25 B;  2PK2 A;  1AIS B;  2CCI B;  4EOS B;  2W2H A;  4G6L B;  1OL2 B;  3BLR B;  1OL1 B;  1JKW A;  5LQF B;  2UZB B;  2WIP B;  4BCM B;  1H27 B;  1JST B;  1QMZ B;  4F70 B;  2W9Z A;  4EOP B;  1OGU B;  2W99 A;  2IW8 B;  2C4G B;  1GY3 B;  2PHG A;  4BCK B;  1OKV B;  4CFW B;  4EOM B;  1P5E B;  3EJ1 B;  1OKW B;  2C5N B;  4NST B;  5HBJ B;  4YOS A;  2UZE B;  2WEV B;  2WFY B;  5HBH B;  3TNH B;  4EOQ B;  1E9H B;  4EOJ B;  4F7S B;  4BCG B;  4YOO A;  5HVY B;  2WPA B;  1TFB A;  3F5X B;  4UN0 A;  4BCQ B;  1H1S B;  4FX3 B;  1H1R B;  2WIH B;  2I40 B;  1GH6 B;  3DOG B;  3M03 A;  3BHT B;  3POM A;  2R7G A;  1BU2 A;  4CFU B;  5CYI B;  1O9K B;  4KRD B;  4Y72 B;  1H1Q B;  4TTH A;  4I3Z B;  3BLQ B;  3DDP B;  2C6T B;  1OIU B;  2BPM B;  3O0G D;  1GUX B;  3RGF B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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