4F6U | Genus

Total Genus 98

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	98
sequence length	267
structure length	267
Chain Sequence	DKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Transferase/transcription/inhibitor
source organism	Homo sapiens
publication title	Structure-kinetic relationship study of CDK8/CycC specific compounds. pubmed doi rcsb
molecule keywords	Cyclin-dependent kinase 8
total genus	98
structure length	267
sequence length	267
ec nomenclature
pdb deposition date	2012-05-15

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
B	PF00134	Cyclin_N	Cyclin, N-terminal domain
B	PF16899	Cyclin_C_2	Cyclin C-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A; domain 1	Cyclin-like	4f6uB02
1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A; domain 1	Cyclin-like	4f6uB01

4F6SB 4BCMD 4CFUD 4YOSA 3MIAB 4F7SB 5IDNB 2JGZB 4KRCB 3F5XB 1H1RB 1E9HB 4EOJB 2UZBB 1W98B 2W2HA 4EC9B 4EOPB 3G33B 4F7LB 2X1NB 1G3NC 4BCJB 1N4MA 5LMKB 2IW9B 4ROEA 1UNGD 5CEIB 1H1PB 5HBEB 4BCNB 4BCIB 1O9KB 1UNLD 4BCQB 1GUXA 2BKZB 3BHUB 3EOCB 4NSTB 2CCIB 2I53A 3MY1B 2IW8B 1OGUB 4ROCA 4EOQB 4CFWB 1TFBA 1GH6B 4BCKB 2IVXA 4EOIB 1H26B 3K7AM 1FVVB 4FX3B 2CJMB 3BLRB 1H24B 2WMBB 4ELJA 5L2WB 3BHTB 4KRDB 4UN0A 2C5OB 2W96A 4EORB 3QHWB 5HBJB 2BPMB 1OL1B 3BLHB 1XO2A 5ACBA 3DDQB 4BCMB 2EUFA 4YOZA 4CFUB 2UUEB 2WEVB 2PMIB 5HQ0B 2I40B 3DOGB 2C4GB 1P5EB 1OI9B 1PKDB 5IDPB 1H27B 4OGRB 1OIUB 5HVYB 2B9RA 3TN8B 4EONB 1JSTB 5HNBB 2PHGA 5FGKB 4EOKB 4F70B 4CXAB 5HBHB 4F7JB 2PK9B 3M03A 2WIPB 4I3ZB 4EC8B 2W9FA 4II5B 4CFVB 4BCHB 2WIHB 1UNHD 1KXUA 2PK2A 4EOOB 3TNWB 4CFNB 1JOWA 3MI9B 2WFYB 2UZLB 5IF1B 2CCHB 2W9ZA 3BLQB 3RGFB 2WXVB 1OKVB 4BCOB 1OIYB 1JSUB 1BU2A 3TNHB 4CRLB 4G6LB 1D3UB 3LQ5B 3MY5B 2WMAB 3POMA 4YC3B 4OR5B 4CFMB 2QDJA 4CFXB 5I5ZB 4BCPB 4IMYB 5BNJB 4RODA 4ELLA 1GUXB 1AD6A 1VOLA 1URCB 2WHBB 2UZDB 4EOMB 1F5QB 3TNIB 1H1QB 3EJ1B 2IW6B 5LQFB 2C6TB 4F7NB 2C5VB 1QMZB 1VINA 1ZP2A 2C5XB 4BCFB 2R7GA 2G9XB 5EFQB 5CYIB 1VYWB 4F6UB 2UZEB 4YOOA 2W99A 3H4CA 1H1SB 4EOLB 3O0GD 3QHRB 4BCND 1H4LD 4EOSB 1AISB 1JKWA 4BCQD 2V22B 1OKWB 1OL2B 2WPAB 1C9BA 3DDPB 3EIDB 4Y72B 4F6WB 4TTHA 1O9KA 2F2CA 1GY3B 1FINB 5ICPB 3BHVB 2C5NB 1H25B 1H28B 4BCGB
chains in the Genus database with same CATH superfamily

4YOSA 2CZ0B 2JGZB 4KRCB 3F5XB 4EOJB 4EC9B 3G33B 4F7LB 3VKGA 1N4MA 5CEIB 3TW7A 1UNLD 1GUXA 4NSTB 2I53A 2IW8B 4ROCA 3DTOA 2IVXA 5L2WB 2WMBB 3BHTB 3HHTB 5ACBA 5HQ0B 4MFDA 3QYGB 1P5EB 1OI9B 1H27B 2BS4A 1OIUB 4M6VA 3GTMS 3TN8B 3VKHA 4JX5A 4EOKB 3M03A 4II5B 1FKMA 2PJQA 2WFYB 2CCHB 2W9ZA 1JSUB 2WMAB 4CFXB 4OR5B 3X28B 1AD6A 1E7PA 4ZGDB 3X26B 3EJ1B 3WVEB 5LQFB 2C6TB 4F7NB 2ZPGB 2BS3A 2CZ6B 2R7GA 2G9XB 2QFZA 3BG3A 1VYWB 4F6UB 2W99A 4BCND 3X20B 1OL2B 1C9BA 3EIDB 3DL1A 1O9KA 5ICPB 1GY3B 4OB3B 3A8MB 1W98B 4OB1B 4EOPB 1TD6A 2X1NB 4BCJB 4ROEA 4BCNB 4BCIB 2BKZB 3QXEB 3A8OB 4BCKB 1H26B 4HL4A 3BLRB 2DD4B 4BXXX 4EORB 4OB0B 5IHYA 3BLHB 1XO2A 2QQ8A 2WEVB 2I40B 1PKDB 3QZ9B 1JSTB 5HNBB 5FGKB 4F70B 4CXAB 4NC6A 4AI6A 2WIPB 4I3ZB 2WIHB 2PK2A 3TNWB 3X24B 4CFNB 3HZJA 3MI9B 3QZ5B 2UZLB 3BLQB 3RGFB 2DD5B 1OIYB 1BU2A 2G77A 3MY5B 2QDJA 1VOLA 1URCB 2UZDB 2ZPIB 2IW6B 3HO8A 2C5VB 3QWLA 2CZ1B 5DQWA 2C5XB 1ENWA 4JX6A 5EFQB 2UZEB 4MFEA 4YOOA 3H4CA 1H1SB 1UGQB 3QHRB 4EOSB 2WJ9A 3TW6A 1AISB 3B57A 2V22B 1OKWB 2WPAB 2DXCB 2IN3A 4HLQA 3BHVB 4BCGB 2QGSA 4CFUD 3A8HB 2ZPHB 3MIAB 4F7SB 1H1RB 2KR6A 2ZCFB 2IW9B 2D0QB 5HBEB 4BY1X 2CCIB 1GH6B 4EOIB 2CJMB 1H24B 2ZPBB 4KRDB 4UN0A 2W96A 1UGPB 4CFUB 2PMIB 5IDPB 2B9RA 4EONB 4LOCA 5HBHB 2LW4A 1QLBA 2ZPEB 4CFVB 4BCHB 1UNHD 4EOOB 1UGSB 4CRLB 4AKGA 3BG9A 1D3UB 3POMA 5I5ZB 4IMYB 3PO3S 4RODA 4HNUA 4OB2B 3VYHB 2WHBB 4EOMB 3TNIB 2ZPFB 1QMZB 3HB9A 4BCFB 4HNVA 5CYIB 3VYGB 2QDYB 3QYHB 4BBSM 3O0GD 1IREB 3A8LB 4BCQD 3DDPB 4Y72B 4F6WB 4TTHA 1FINB 2C5NB 1H25B 1H28B 4QSHA 4F6SB 4BCMD 3X25B 5IDNB 1E9HB 2DMEA 2CZ7B 2UZBB 2W2HA 3KHIA 4JX4A 3QYBA 2BS2A 4ZGEB 1G3NC 2QF7A 5LMKB 4ZGJB 1UNGD 1H1PB 1O9KB 3WVDB 4BCQB 3BHUB 3EOCB 3MY1B 1OGUB 4EOQB 4CFWB 1TFBA 2CYZB 3K7AM 1FVVB 4FX3B 4ELJA 2C5OB 3QHWB 4MIMA 5HBJB 2BPMB 1OL1B 3DDQB 4BCMB 2EUFA 2DXBB 4YOZA 2UUEB 3DOGB 2C4GB 4OGRB 5HVYB 4BY7X 2PHGA 4F7JB 2PK9B 4EC8B 2W9FA 3DJBA 1KXUA 2DPPB 1JOWA 4AKIA 5IF1B 4FM4B 4Z6YA 2WXVB 1OKVB 3HBLA 3TNHB 4BCOB 2KMGA 4G6LB 3LQ5B 1AHJB 4YC3B 4CFMB 4BCPB 5BNJB 5DQVA 4ELLA 1GUXB 5EJCA 4HNTA 3BG5A 1F5QB 2ZZDB 1H1QB 4AKHA 3A8GB 1VINA 1ZP2A 3NDQA 4EOLB 1H4LD 1JKWA 1V29B 2AHJB 1UGRB 2F2CA 3QYEA 4BBRM
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4F6S B;  4BCM D;  4CFU D;  4YOS A;  3MIA B;  4F7S B;  5IDN B;  2JGZ B;  4KRC B;  3F5X B;  1H1R B;  1E9H B;  4EOJ B;  2UZB B;  1W98 B;  2W2H A;  4EC9 B;  4EOP B;  3G33 B;  4F7L B;  2X1N B;  1G3N C;  4BCJ B;  1N4M A;  5LMK B;  2IW9 B;  4ROE A;  1UNG D;  5CEI B;  1H1P B;  5HBE B;  4BCN B;  4BCI B;  1O9K B;  1UNL D;  4BCQ B;  1GUX A;  2BKZ B;  3BHU B;  3EOC B;  4NST B;  2CCI B;  2I53 A;  3MY1 B;  2IW8 B;  1OGU B;  4ROC A;  4EOQ B;  4CFW B;  1TFB A;  1GH6 B;  4BCK B;  2IVX A;  4EOI B;  1H26 B;  3K7A M;  1FVV B;  4FX3 B;  2CJM B;  3BLR B;  1H24 B;  2WMB B;  4ELJ A;  5L2W B;  3BHT B;  4KRD B;  4UN0 A;  2C5O B;  2W96 A;  4EOR B;  3QHW B;  5HBJ B;  2BPM B;  1OL1 B;  3BLH B;  1XO2 A;  5ACB A;  3DDQ B;  4BCM B;  2EUF A;  4YOZ A;  4CFU B;  2UUE B;  2WEV B;  2PMI B;  5HQ0 B;  2I40 B;  3DOG B;  2C4G B;  1P5E B;  1OI9 B;  1PKD B;  5IDP B;  1H27 B;  4OGR B;  1OIU B;  5HVY B;  2B9R A;  3TN8 B;  4EON B;  1JST B;  5HNB B;  2PHG A;  5FGK B;  4EOK B;  4F70 B;  4CXA B;  5HBH B;  4F7J B;  2PK9 B;  3M03 A;  2WIP B;  4I3Z B;  4EC8 B;  2W9F A;  4II5 B;  4CFV B;  4BCH B;  2WIH B;  1UNH D;  1KXU A;  2PK2 A;  4EOO B;  3TNW B;  4CFN B;  1JOW A;  3MI9 B;  2WFY B;  2UZL B;  5IF1 B;  2CCH B;  2W9Z A;  3BLQ B;  3RGF B;  2WXV B;  1OKV B;  4BCO B;  1OIY B;  1JSU B;  1BU2 A;  3TNH B;  4CRL B;  4G6L B;  1D3U B;  3LQ5 B;  3MY5 B;  2WMA B;  3POM A;  4YC3 B;  4OR5 B;  4CFM B;  2QDJ A;  4CFX B;  5I5Z B;  4BCP B;  4IMY B;  5BNJ B;  4ROD A;  4ELL A;  1GUX B;  1AD6 A;  1VOL A;  1URC B;  2WHB B;  2UZD B;  4EOM B;  1F5Q B;  3TNI B;  1H1Q B;  3EJ1 B;  2IW6 B;  5LQF B;  2C6T B;  4F7N B;  2C5V B;  1QMZ B;  1VIN A;  1ZP2 A;  2C5X B;  4BCF B;  2R7G A;  2G9X B;  5EFQ B;  5CYI B;  1VYW B;  4F6U B;  2UZE B;  4YOO A;  2W99 A;  3H4C A;  1H1S B;  4EOL B;  3O0G D;  3QHR B;  4BCN D;  1H4L D;  4EOS B;  1AIS B;  1JKW A;  4BCQ D;  2V22 B;  1OKW B;  1OL2 B;  2WPA B;  1C9B A;  3DDP B;  3EID B;  4Y72 B;  4F6W B;  4TTH A;  1O9K A;  2F2C A;  1GY3 B;  1FIN B;  5ICP B;  3BHV B;  2C5N B;  1H25 B;  1H28 B;  4BCG B; 
#chains in the Genus database with same CATH topology
 4YOS A;  2CZ0 B;  2JGZ B;  4KRC B;  3F5X B;  4EOJ B;  4EC9 B;  3G33 B;  4F7L B;  3VKG A;  1N4M A;  5CEI B;  3TW7 A;  1UNL D;  1GUX A;  4NST B;  2I53 A;  2IW8 B;  4ROC A;  3DTO A;  2IVX A;  5L2W B;  2WMB B;  3BHT B;  3HHT B;  5ACB A;  5HQ0 B;  4MFD A;  3QYG B;  1P5E B;  1OI9 B;  1H27 B;  2BS4 A;  1OIU B;  4M6V A;  3GTM S;  3TN8 B;  3VKH A;  4JX5 A;  4EOK B;  3M03 A;  4II5 B;  1FKM A;  2PJQ A;  2WFY B;  2CCH B;  2W9Z A;  1JSU B;  2WMA B;  4CFX B;  4OR5 B;  3X28 B;  1AD6 A;  1E7P A;  4ZGD B;  3X26 B;  3EJ1 B;  3WVE B;  5LQF B;  2C6T B;  4F7N B;  2ZPG B;  2BS3 A;  2CZ6 B;  2R7G A;  2G9X B;  2QFZ A;  3BG3 A;  1VYW B;  4F6U B;  2W99 A;  4BCN D;  3X20 B;  1OL2 B;  1C9B A;  3EID B;  3DL1 A;  1O9K A;  5ICP B;  1GY3 B;  4OB3 B;  3A8M B;  1W98 B;  4OB1 B;  4EOP B;  1TD6 A;  2X1N B;  4BCJ B;  4ROE A;  4BCN B;  4BCI B;  2BKZ B;  3QXE B;  3A8O B;  4BCK B;  1H26 B;  4HL4 A;  3BLR B;  2DD4 B;  4BXX X;  4EOR B;  4OB0 B;  5IHY A;  3BLH B;  1XO2 A;  2QQ8 A;  2WEV B;  2I40 B;  1PKD B;  3QZ9 B;  1JST B;  5HNB B;  5FGK B;  4F70 B;  4CXA B;  4NC6 A;  4AI6 A;  2WIP B;  4I3Z B;  2WIH B;  2PK2 A;  3TNW B;  3X24 B;  4CFN B;  3HZJ A;  3MI9 B;  3QZ5 B;  2UZL B;  3BLQ B;  3RGF B;  2DD5 B;  1OIY B;  1BU2 A;  2G77 A;  3MY5 B;  2QDJ A;  1VOL A;  1URC B;  2UZD B;  2ZPI B;  2IW6 B;  3HO8 A;  2C5V B;  3QWL A;  2CZ1 B;  5DQW A;  2C5X B;  1ENW A;  4JX6 A;  5EFQ B;  2UZE B;  4MFE A;  4YOO A;  3H4C A;  1H1S B;  1UGQ B;  3QHR B;  4EOS B;  2WJ9 A;  3TW6 A;  1AIS B;  3B57 A;  2V22 B;  1OKW B;  2WPA B;  2DXC B;  2IN3 A;  4HLQ A;  3BHV B;  4BCG B;  2QGS A;  4CFU D;  3A8H B;  2ZPH B;  3MIA B;  4F7S B;  1H1R B;  2KR6 A;  2ZCF B;  2IW9 B;  2D0Q B;  5HBE B;  4BY1 X;  2CCI B;  1GH6 B;  4EOI B;  2CJM B;  1H24 B;  2ZPB B;  4KRD B;  4UN0 A;  2W96 A;  1UGP B;  4CFU B;  2PMI B;  5IDP B;  2B9R A;  4EON B;  4LOC A;  5HBH B;  2LW4 A;  1QLB A;  2ZPE B;  4CFV B;  4BCH B;  1UNH D;  4EOO B;  1UGS B;  4CRL B;  4AKG A;  3BG9 A;  1D3U B;  3POM A;  5I5Z B;  4IMY B;  3PO3 S;  4ROD A;  4HNU A;  4OB2 B;  3VYH B;  2WHB B;  4EOM B;  3TNI B;  2ZPF B;  1QMZ B;  3HB9 A;  4BCF B;  4HNV A;  5CYI B;  3VYG B;  2QDY B;  3QYH B;  4BBS M;  3O0G D;  1IRE B;  3A8L B;  4BCQ D;  3DDP B;  4Y72 B;  4F6W B;  4TTH A;  1FIN B;  2C5N B;  1H25 B;  1H28 B;  4QSH A;  4F6S B;  4BCM D;  3X25 B;  5IDN B;  1E9H B;  2DME A;  2CZ7 B;  2UZB B;  2W2H A;  3KHI A;  4JX4 A;  3QYB A;  2BS2 A;  4ZGE B;  1G3N C;  2QF7 A;  5LMK B;  4ZGJ B;  1UNG D;  1H1P B;  1O9K B;  3WVD B;  4BCQ B;  3BHU B;  3EOC B;  3MY1 B;  1OGU B;  4EOQ B;  4CFW B;  1TFB A;  2CYZ B;  3K7A M;  1FVV B;  4FX3 B;  4ELJ A;  2C5O B;  3QHW B;  4MIM A;  5HBJ B;  2BPM B;  1OL1 B;  3DDQ B;  4BCM B;  2EUF A;  2DXB B;  4YOZ A;  2UUE B;  3DOG B;  2C4G B;  4OGR B;  5HVY B;  4BY7 X;  2PHG A;  4F7J B;  2PK9 B;  4EC8 B;  2W9F A;  3DJB A;  1KXU A;  2DPP B;  1JOW A;  4AKI A;  5IF1 B;  4FM4 B;  4Z6Y A;  2WXV B;  1OKV B;  3HBL A;  3TNH B;  4BCO B;  2KMG A;  4G6L B;  3LQ5 B;  1AHJ B;  4YC3 B;  4CFM B;  4BCP B;  5BNJ B;  5DQV A;  4ELL A;  1GUX B;  5EJC A;  4HNT A;  3BG5 A;  1F5Q B;  2ZZD B;  1H1Q B;  4AKH A;  3A8G B;  1VIN A;  1ZP2 A;  3NDQ A;  4EOL B;  1H4L D;  1JKW A;  1V29 B;  2AHJ B;  1UGR B;  2F2C A;  3QYE A;  4BBR M; 
#chains in the Genus database with same CATH homology
 4F6S B;  4BCM D;  4CFU D;  4YOS A;  3MIA B;  4F7S B;  5IDN B;  2JGZ B;  4KRC B;  3F5X B;  1H1R B;  1E9H B;  4EOJ B;  2UZB B;  1W98 B;  2W2H A;  4EC9 B;  4EOP B;  3G33 B;  4F7L B;  2X1N B;  1G3N C;  4BCJ B;  1N4M A;  5LMK B;  2IW9 B;  4ROE A;  1UNG D;  5CEI B;  1H1P B;  5HBE B;  4BCN B;  4BCI B;  1O9K B;  1UNL D;  4BCQ B;  1GUX A;  2BKZ B;  3BHU B;  3EOC B;  4NST B;  2CCI B;  2I53 A;  3MY1 B;  2IW8 B;  1OGU B;  4ROC A;  4EOQ B;  4CFW B;  1TFB A;  1GH6 B;  4BCK B;  2IVX A;  4EOI B;  1H26 B;  3K7A M;  1FVV B;  4FX3 B;  2CJM B;  3BLR B;  1H24 B;  2WMB B;  4ELJ A;  5L2W B;  3BHT B;  4KRD B;  4UN0 A;  2C5O B;  2W96 A;  4EOR B;  3QHW B;  5HBJ B;  2BPM B;  1OL1 B;  3BLH B;  1XO2 A;  5ACB A;  3DDQ B;  4BCM B;  2EUF A;  4YOZ A;  4CFU B;  2UUE B;  2WEV B;  2PMI B;  5HQ0 B;  2I40 B;  3DOG B;  2C4G B;  1P5E B;  1OI9 B;  1PKD B;  5IDP B;  1H27 B;  4OGR B;  1OIU B;  5HVY B;  2B9R A;  3TN8 B;  4EON B;  1JST B;  5HNB B;  2PHG A;  5FGK B;  4EOK B;  4F70 B;  4CXA B;  5HBH B;  4F7J B;  2PK9 B;  3M03 A;  2WIP B;  4I3Z B;  4EC8 B;  2W9F A;  4II5 B;  4CFV B;  4BCH B;  2WIH B;  1UNH D;  1KXU A;  2PK2 A;  4EOO B;  3TNW B;  4CFN B;  1JOW A;  3MI9 B;  2WFY B;  2UZL B;  5IF1 B;  2CCH B;  2W9Z A;  3BLQ B;  3RGF B;  2WXV B;  1OKV B;  4BCO B;  1OIY B;  1JSU B;  1BU2 A;  3TNH B;  4CRL B;  4G6L B;  1D3U B;  3LQ5 B;  3MY5 B;  2WMA B;  3POM A;  4YC3 B;  4OR5 B;  4CFM B;  2QDJ A;  4CFX B;  5I5Z B;  4BCP B;  4IMY B;  5BNJ B;  4ROD A;  4ELL A;  1GUX B;  1AD6 A;  1VOL A;  1URC B;  2WHB B;  2UZD B;  4EOM B;  1F5Q B;  3TNI B;  1H1Q B;  3EJ1 B;  2IW6 B;  5LQF B;  2C6T B;  4F7N B;  2C5V B;  1QMZ B;  1VIN A;  1ZP2 A;  2C5X B;  4BCF B;  2R7G A;  2G9X B;  5EFQ B;  5CYI B;  1VYW B;  4F6U B;  2UZE B;  4YOO A;  2W99 A;  3H4C A;  1H1S B;  4EOL B;  3O0G D;  3QHR B;  4BCN D;  1H4L D;  4EOS B;  1AIS B;  1JKW A;  4BCQ D;  2V22 B;  1OKW B;  1OL2 B;  2WPA B;  1C9B A;  3DDP B;  3EID B;  4Y72 B;  4F6W B;  4TTH A;  1O9K A;  2F2C A;  1GY3 B;  1FIN B;  5ICP B;  3BHV B;  2C5N B;  1H25 B;  1H28 B;  4BCG B;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4F6UB

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations