The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
86
|
sequence length |
247
|
structure length |
244
|
Chain Sequence |
LNRAKIDSTTMKDPRVLNNLKLRELLLPKFTSLWEIQTEVTVDNRTILLTWMHLLCESFELDKSVFPLSVSILDRYLCKKQGTKKTLQKIGAACVLIGSKIRTVKPMTVSKLTYLSFTNLELINQEKDILEALKWDTEAVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
pubmed doi rcsb |
| molecule tags |
Transferase/cell cycle/inhibitor
|
| source organism |
Saimiriine herpesvirus 2
|
| molecule keywords |
Cyclin homolog
|
| total genus |
86
|
| structure length |
244
|
| sequence length |
247
|
| ec nomenclature | |
| pdb deposition date | 2014-06-20 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00134 | Cyclin_N | Cyclin, N-terminal domain |
| A | PF09241 | Herp-Cyclin | Herpesviridae viral cyclin |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Cyclin A; domain 1 | Cyclin-like | ||
| Mainly Alpha | Orthogonal Bundle | Cyclin A; domain 1 | Cyclin-like |
#chains in the Genus database with same CATH superfamily 4F7L B; 1OL1 B; 4EOQ B; 1UNL D; 1H28 B; 2PK2 A; 1OKV B; 1FVV B; 4EOS B; 1OI9 B; 5HNB B; 3MI9 B; 4BCF B; 5IF1 B; 3BLQ B; 4EON B; 3POM A; 2CJM B; 5HBJ B; 1GH6 B; 1OIY B; 5ICP B; 5HBH B; 3EID B; 4YOS A; 3EJ1 B; 4YOO A; 2R7G A; 5CYI B; 2I53 A; 3TNW B; 3BHU B; 1VYW B; 4IMY B; 4BCM B; 4CFX B; 2WMB B; 2UZD B; 4BCQ B; 1H1R B; 2IW8 B; 1AIS B; 4BCP B; 2V22 B; 1H1S B; 2PMI B; 4EOI B; 2WIH B; 1UNH D; 1ZP2 A; 3F5X B; 4OGR B; 4YOZ A; 1OL2 B; 1PKD B; 1O9K B; 1E9H B; 3K7A M; 5HBE B; 5EFQ B; 1JSU B; 4BCH B; 4CFM B; 4F70 B; 2C5N B; 4NST B; 1TFB A; 2BPM B; 4CXA B; 5HVY B; 2WIP B; 2WFY B; 5I5Z B; 1H1Q B; 2C5X B; 3BHT B; 4F6W B; 1URC B; 3QHR B; 3LQ5 B; 2WMA B; 4FX3 B; 1H1P B; 2WEV B; 4BCG B; 2X1N B; 4CRL B; 2WHB B; 1N4M A; 2EUF A; 2UZL B; 3EOC B; 1OGU B; 4OR5 B; 4YC3 B; 3M03 A; 1GUX B; 2I40 B; 4G6L B; 4BCN B; 4F6U B; 2B9R A; 4TTH A; 5LQF B; 2BKZ B; 1D3U B; 3DDQ B; 2IW9 B; 3TNI B; 2UZE B; 4EC8 B; 2W2H A; 4CFU D; 4CFW B; 4UN0 A; 1H27 B; 4EC9 B; 2JGZ B; 2UZB B; 2WPA B; 2PK9 B; 1C9B A; 2CCI B; 3DOG B; 3QHW B; 2W96 A; 4CFN B; 3O0G D; 4F7S B; 2QDJ A; 5BNJ B; 4BCO B; 4EOO B; 1OIU B; 4CFV B; 4EOJ B; 1P5E B; 1AD6 A; 3MY5 B; 1W98 B; 1GY3 B; 3MY1 B; 2UUE B; 1QMZ B; 5CEI B; 4ELJ A; 1BU2 A; 5ACB A; 1H26 B; 5HQ0 B; 4KRC B; 4F7N B; 2IVX A; 3MIA B; 4ELL A; 4BCM D; 5L2W B; 4II5 B; 4BCN D; 4BCQ D; 1O9K A; 4EOL B; 4BCI B; 3BHV B; 2WXV B; 1OKW B; 1JST B; 3BLH B; 2IW6 B; 4Y72 B; 4BCJ B; 1H24 B; 4I3Z B; 3RGF B; 4BCK B; 1JOW A; 5IDP B; 4ROE A; 4EOP B; 1H4L D; 1F5Q B; 4F7J B; 3TNH B; 1G3N C; 1XO2 A; 2G9X B; 2W9Z A; 4ROD A; 4KRD B; 1FIN B; 1VOL A; 1KXU A; 3DDP B; 2W9F A; 5FGK B; 3G33 B; 2C6T B; 2PHG A; 4EOM B; 4ROC A; 5IDN B; 1UNG D; 4EOK B; 2C4G B; 3TN8 B; 1GUX A; 1JKW A; 1H25 B; 2W99 A; 2F2C A; 2C5O B; 4EOR B; 4CFU B; 1VIN A; 3H4C A; 2CCH B; 4F6S B; 3BLR B; 5LMK B; 2C5V B; #chains in the Genus database with same CATH topology 4HNU A; 4EOQ B; 5HNB B; 3MI9 B; 4HNT A; 3BLQ B; 4EON B; 5HBH B; 4YOS A; 4YOO A; 2LW4 A; 1VYW B; 4CFX B; 4OB1 B; 4BCQ B; 2V22 B; 1H1S B; 1PKD B; 1O9K B; 1E9H B; 4CFM B; 2WIP B; 3BHT B; 4F6W B; 2QQ8 A; 4OB0 B; 2BS2 A; 3QHR B; 4AKG A; 3LQ5 B; 2WMA B; 4FX3 B; 4BCG B; 2IN3 A; 1N4M A; 2I40 B; 4F6U B; 4BCN B; 3DDQ B; 3VYG B; 2W2H A; 3BG3 A; 3A8O B; 1AHJ B; 3GTM S; 2UZB B; 4CFN B; 3QHW B; 3X25 B; 3O0G D; 2QDJ A; 4JX5 A; 1FKM A; 4CFV B; 1AD6 A; 2DXC B; 3DL1 A; 1GY3 B; 4FM4 B; 3QYH B; 5CEI B; 1BU2 A; 5ACB A; 3MIA B; 4ELL A; 2CZ1 B; 3DTO A; 1OKW B; 4Y72 B; 3RGF B; 1JOW A; 3HBL A; 1FIN B; 3G33 B; 2C6T B; 4EOM B; 5IDN B; 1UNG D; 4Z6Y A; 2C4G B; 3TN8 B; 4EOR B; 2WJ9 A; 2C5V B; 4BXX X; 1ENW A; 1OL1 B; 1H28 B; 5IF1 B; 2DPP B; 2CJM B; 3QZ5 B; 3X28 B; 2R7G A; 2ZPF B; 3BHU B; 4ZGD B; 4BCM B; 2UZD B; 4AKH A; 1H1R B; 2IW8 B; 2PMI B; 1ZP2 A; 3F5X B; 3PO3 S; 4YOZ A; 2ZZD B; 3K7A M; 3QWL A; 5HBE B; 1JSU B; 1TFB A; 2BPM B; 5HVY B; 2WFY B; 3HB9 A; 1H1Q B; 2C5X B; 1TD6 A; 2PJQ A; 2BS3 A; 2KMG A; 1URC B; 1H1P B; 2X1N B; 2EUF A; 4HNV A; 1OGU B; 3M03 A; 3HZJ A; 2B9R A; 1D3U B; 2AHJ B; 2IW9 B; 2DD4 B; 2UZE B; 4EC8 B; 2CYZ B; 4UN0 A; 4EC9 B; 3BG9 A; 4BY1 X; 3DOG B; 4F7S B; 3QZ9 B; 2G77 A; 1OIU B; 4OB3 B; 4EOJ B; 1UGS B; 4ELJ A; 2KR6 A; 2QGS A; 4F7N B; 2IVX A; 2CZ7 B; 5L2W B; 3WVD B; 4BCN D; 4EOL B; 4BCI B; 4JX4 A; 3BLH B; 1H24 B; 4BCK B; 1H4L D; 3TNH B; 2W9Z A; 3TW6 A; 4MFD A; 2PHG A; 3HHT B; 1GUX A; 4HL4 A; 1E7P A; 2BS4 A; 3H4C A; 3A8G B; 1UNL D; 2ZCF B; 2PK2 A; 1OI9 B; 4BCF B; 2DD5 B; 5HBJ B; 5ICP B; 1GH6 B; 1OIY B; 4QSH A; 4NC6 A; 3EID B; 4M6V A; 3A8M B; 5CYI B; 3TNW B; 3NDQ A; 2WMB B; 1AIS B; 4BCP B; 4EOI B; 2WIH B; 1UNH D; 5EFQ B; 4BCH B; 4F70 B; 2CZ0 B; 2C5N B; 4NST B; 5I5Z B; 4LOC A; 4CRL B; 2WHB B; 3EOC B; 3VYH B; 4OR5 B; 4YC3 B; 1GUX B; 1QLB A; 4G6L B; 3A8H B; 4TTH A; 3VKH A; 4CFU D; 2ZPE B; 2PK9 B; 3HO8 A; 2CCI B; 2W96 A; 5BNJ B; 4BCO B; 4EOO B; 4JX6 A; 1W98 B; 2UUE B; 1QMZ B; 1H26 B; 4KRC B; 3X20 B; 4BCQ D; 3DJB A; 3BHV B; 2WXV B; 1JST B; 4BCJ B; 4HLQ A; 4EOP B; 3X26 B; 4MFE A; 3QXE B; 4ROD A; 3TW7 A; 2QFZ A; 1VOL A; 3KHI A; 4ROC A; 2DXB B; 3A8L B; 5DQW A; 4EOK B; 1JKW A; 2QF7 A; 1H25 B; 2W99 A; 2C5O B; 3X24 B; 4MIM A; 4F7L B; 1OKV B; 1FVV B; 4EOS B; 3B57 A; 3POM A; 3EJ1 B; 2ZPI B; 2I53 A; 4AKI A; 4IMY B; 4OGR B; 1OL2 B; 4CXA B; 5DQV A; 3QYE A; 1IRE B; 4AI6 A; 2WEV B; 3WVE B; 2UZL B; 5LQF B; 2BKZ B; 2ZPH B; 3TNI B; 3QYB A; 4OB2 B; 4CFW B; 1H27 B; 2JGZ B; 2WPA B; 1V29 B; 1C9B A; 4BY7 X; 2ZPB B; 2CZ6 B; 4BBS M; 1P5E B; 3MY5 B; 3MY1 B; 3QYG B; 4ZGE B; 2D0Q B; 5HQ0 B; 4BCM D; 4ZGJ B; 4II5 B; 1UGR B; 1O9K A; 3BG5 A; 2IW6 B; 2ZPG B; 5EJC A; 4I3Z B; 3VKG A; 2DME A; 5IDP B; 4ROE A; 1F5Q B; 4F7J B; 5IHY A; 1G3N C; 1XO2 A; 2G9X B; 4KRD B; 1KXU A; 3DDP B; 2W9F A; 5FGK B; 1UGQ B; 2F2C A; 4CFU B; 4BBR M; 2QDY B; 1VIN A; 2CCH B; 1UGP B; 4F6S B; 3BLR B; 5LMK B; #chains in the Genus database with same CATH homology 4F7L B; 1OL1 B; 4EOQ B; 1UNL D; 1H28 B; 2PK2 A; 1OKV B; 1FVV B; 4EOS B; 1OI9 B; 5HNB B; 3MI9 B; 4BCF B; 5IF1 B; 3BLQ B; 4EON B; 3POM A; 2CJM B; 5HBJ B; 1GH6 B; 1OIY B; 5ICP B; 5HBH B; 3EID B; 4YOS A; 3EJ1 B; 4YOO A; 2R7G A; 5CYI B; 2I53 A; 3TNW B; 3BHU B; 1VYW B; 4IMY B; 4BCM B; 4CFX B; 2WMB B; 2UZD B; 4BCQ B; 1H1R B; 2IW8 B; 1AIS B; 4BCP B; 2V22 B; 1H1S B; 2PMI B; 4EOI B; 2WIH B; 1UNH D; 1ZP2 A; 3F5X B; 4OGR B; 4YOZ A; 1OL2 B; 1PKD B; 1O9K B; 1E9H B; 3K7A M; 5HBE B; 5EFQ B; 1JSU B; 4BCH B; 4CFM B; 4F70 B; 2C5N B; 4NST B; 1TFB A; 2BPM B; 4CXA B; 5HVY B; 2WIP B; 2WFY B; 5I5Z B; 1H1Q B; 2C5X B; 3BHT B; 4F6W B; 1URC B; 3QHR B; 3LQ5 B; 2WMA B; 4FX3 B; 1H1P B; 2WEV B; 4BCG B; 2X1N B; 4CRL B; 2WHB B; 1N4M A; 2EUF A; 2UZL B; 3EOC B; 1OGU B; 4OR5 B; 4YC3 B; 3M03 A; 1GUX B; 2I40 B; 4G6L B; 4BCN B; 4F6U B; 2B9R A; 4TTH A; 5LQF B; 2BKZ B; 1D3U B; 3DDQ B; 2IW9 B; 3TNI B; 2UZE B; 4EC8 B; 2W2H A; 4CFU D; 4CFW B; 4UN0 A; 1H27 B; 4EC9 B; 2JGZ B; 2UZB B; 2WPA B; 2PK9 B; 1C9B A; 2CCI B; 3DOG B; 3QHW B; 2W96 A; 4CFN B; 3O0G D; 4F7S B; 2QDJ A; 5BNJ B; 4BCO B; 4EOO B; 1OIU B; 4CFV B; 4EOJ B; 1P5E B; 1AD6 A; 3MY5 B; 1W98 B; 1GY3 B; 3MY1 B; 2UUE B; 1QMZ B; 5CEI B; 4ELJ A; 1BU2 A; 5ACB A; 1H26 B; 5HQ0 B; 4KRC B; 4F7N B; 2IVX A; 3MIA B; 4ELL A; 4BCM D; 5L2W B; 4II5 B; 4BCN D; 4BCQ D; 1O9K A; 4EOL B; 4BCI B; 3BHV B; 2WXV B; 1OKW B; 1JST B; 3BLH B; 2IW6 B; 4Y72 B; 4BCJ B; 1H24 B; 4I3Z B; 3RGF B; 4BCK B; 1JOW A; 5IDP B; 4ROE A; 4EOP B; 1H4L D; 1F5Q B; 4F7J B; 3TNH B; 1G3N C; 1XO2 A; 2G9X B; 2W9Z A; 4ROD A; 4KRD B; 1FIN B; 1VOL A; 1KXU A; 3DDP B; 2W9F A; 5FGK B; 3G33 B; 2C6T B; 2PHG A; 4EOM B; 4ROC A; 5IDN B; 1UNG D; 4EOK B; 2C4G B; 3TN8 B; 1GUX A; 1JKW A; 1H25 B; 2W99 A; 2F2C A; 2C5O B; 4EOR B; 4CFU B; 1VIN A; 3H4C A; 2CCH B; 4F6S B; 3BLR B; 5LMK B; 2C5V B;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
