5IDNB

Cdk8-cycc in complex with [(s)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)-methanone
Total Genus 94

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
267
structure length
267
Chain Sequence
DKAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPP

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
3H1 (5-7)TII1 (-1-2)TII2 (1-4)AH8 (155-166)AH1 (9-14)3H2 (188-190)AH2 (18-30)EMPTYTI1 (77-80)TIV1 (78-81)AH3 (34-55)AH6 (105-120)AH4 (59-75)TVIII1 (79-82)AH5 (83-98)AH10 (194-209)AH12 (224-243)AH11 (214-219)3H3 (246-248)AH13 (249-256)AH7 (132-146)TI2 (120-123)TI'1 (146-149)AH9 (169-184)Updating...
connected with : NaN
molecule tags Transferase
source organism Homo sapiens
publication title Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
pubmed doi rcsb
molecule keywords Cyclin-dependent kinase 8
total genus 94
structure length 267
sequence length 267
ec nomenclature
pdb deposition date 2016-02-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00134 Cyclin_N Cyclin, N-terminal domain
B PF16899 Cyclin_C_2 Cyclin C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 5idnB02
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 5idnB01
1QMZB 3DDQB 1JKWA 3TN8B 4BCMB 4CFWB 4F6SB 4EC9B 4EORB 2BPMB 4BCFB 3F5XB 3EJ1B 4OR5B 4EOLB 3TNWB 4F7JB 1W98B 5IDNB 4BCQD 1VINA 3O0GD 2C5VB 4IMYB 1O9KA 2W99A 2C5OB 2W96A 2IVXA 4ELLA 3MY1B 4BCPB 4KRDB 1XO2A 1H1PB 1G3NC 3BHTB 2JGZB 2CCIB 3TNHB 3EIDB 4EC8B 1F5QB 1GUXA 1GY3B 4BCNB 2IW6B 3DOGB 4YOOA 4BCMD 2I40B 3MY5B 5EFQB 1JOWA 1OI9B 1OKWB 1ZP2A 2W9FA 3M03A 3RGFB 1P5EB 2I53A 5CEIB 2PHGA 2WHBB 2IW8B 3BLHB 3DDPB 4CFUD 1OGUB 5HQ0B 4II5B 3K7AM 4YOSA 1AD6A 2UZEB 1UNGD 3BLRB 4YC3B 2QDJA 2X1NB 4YOZA 1VYWB 5IF1B 4EONB 2C4GB 4F6UB 4BCIB 1E9HB 2WXVB 2IW9B 4EOIB 4F7SB 1H24B 1H25B 3H4CA 1AISB 5HVYB 1UNHD 1FINB 2PK2A 1BU2A 1TFBA 5HBHB 2C5XB 4CFVB 2BKZB 2UZBB 4BCKB 1D3UB 1VOLA 2PMIB 4EOQB 2UZLB 1H27B 3TNIB 3MIAB 4CRLB 4G6LB 4CFXB 2WMAB 1H1QB 1H28B 1OIYB 1JSUB 2C6TB 2PK9B 5BNJB 3EOCB 4BCQB 2R7GA 4KRCB 2W9ZA 1H4LD 5HBJB 1KXUA 2W2HA 5IDPB 4EOSB 4BCOB 5CYIB 2UUEB 1H1RB 1PKDB 3POMA 1OIUB 4I3ZB 4NSTB 5I5ZB 1URCB 4BCHB 2CCHB 1GUXB 4F7LB 4OGRB 3G33B 4EOOB 4CXAB 1N4MA 2F2CA 4EOPB 4BCND 5L2WB 5LQFB 2WIPB 1OL1B 2G9XB 5LMKB 4UN0A 5HBEB 1OKVB 5ACBA 4FX3B 2UZDB 3LQ5B 2CJMB 3QHRB 4F7NB 4EOKB 2V22B 4RODA 2WPAB 1UNLD 4CFUB 4CFMB 3BHUB 2WEVB 5ICPB 4F6WB 1O9KB 4BCGB 1H26B 4Y72B 1H1SB 4BCJB 4EOMB 4F70B 4TTHA 4CFNB 1OL2B 4ELJA 2C5NB 1JSTB 2WMBB 5FGKB 2EUFA 3BHVB 5HNBB 4EOJB 3BLQB 1C9BA 1GH6B 3QHWB 4ROEA 3MI9B 4ROCA 2WFYB 2B9RA 2WIHB 1FVVB
chains in the Genus database with same CATH superfamily
3DDQB 3TN8B 4BCMB 4F6SB 3BG9A 1UGQB 3A8OB 3VYHB 4BCQD 4HNTA 2C5VB 4IMYB 2DD5B 2C5OB 2W96A 4Z6YA 1G3NC 2JGZB 4MIMA 3EIDB 1GY3B 1GUXA 2DD4B 2CZ0B 2ZZDB 1OKWB 1ZP2A 2W9FA 1P5EB 5CEIB 2WHBB 2IW8B 4CFUD 4FM4B 1OGUB 4YOSA 3DL1A 4YOZA 2C4GB 1E9HB 3H4CA 2PK2A 1TFBA 5HBHB 2C5XB 4NC6A 4OB2B 1H28B 1OIYB 2ZCFB 3GTMS 2CZ1B 4KRCB 3PO3S 4EOSB 2PJQA 4BCOB 5CYIB 1OIUB 3QWLA 5L2WB 4ZGDB 2F2CA 2WIPB 2G9XB 2G77A 5EJCA 5ACBA 1E7PA 2DMEA 4OB3B 3QHRB 2V22B 2WPAB 4BY1X 4F6WB 2QQ8A 4BCJB 4F70B 5FGKB 2WMBB 2IN3A 5HNBB 1C9BA 4HL4A 3QHWB 2WFYB 1JKWA 3VYGB 4EORB 4BCFB 4JX5A 1TD6A 3EJ1B 2AHJB 3TNWB 3NDQA 1W98B 3BG5A 2BS2A 3X26B 4BCPB 1H1PB 3BHTB 2CCIB 2QDYB 4MFDA 4BCNB 3DOGB 2I40B 3X24B 3DDPB 2ZPHB 4AKHA 3BLRB 4YC3B 3A8HB 5IF1B 4BBSM 1H24B 3TW6A 1H25B 3KHIA 5HVYB 1FINB 1BU2A 3HB9A 2KMGA 4BCKB 2PMIB 4BBRM 3MIAB 3QYEA 2PK9B 3TW7A 5BNJB 2QFZA 3VKHA 5HBJB 3VKGA 4HNVA 1AHJB 2UUEB 1H1RB 4NSTB 4I3ZB 5IHYA 2CCHB 1GUXB 3QYGB 3X25B 4F7LB 1N4MA 4BCND 5LMKB 4HLQA 2D0QB 3LQ5B 2CJMB 4AKGA 1O9KB 1H26B 1H1SB 2CZ7B 4EOMB 3HZJA 2C5NB 3BHVB 3X28B 4AKIA 4BXXX 4ROEA 2WIHB 1FVVB 2BS3A 4CFWB 4EOLB 1VINA 2ZPIB 4ELLA 3DJBA 1UGPB 1XO2A 4EC8B 2ZPBB 1IREB 5EFQB 1OI9B 3M03A 3RGFB 1UGSB 2I53A 2PHGA 3BLHB 1ENWA 3QYBA 4II5B 3K7AM 4F7SB 4AI6A 3QYHB 1UNHD 4MFEA 4CFVB 2BKZB 3QZ5B 2UZBB 1VOLA 4EOQB 2UZLB 3TNIB 4CRLB 1UGRB 2WMAB 1JSUB 3EOCB 2QGSA 2R7GA 1KXUA 2W2HA 5IDPB 3POMA 1PKDB 4JX4A 5I5ZB 1URCB 3HHTB 3G33B 4EOOB 3A8LB 4UN0A 4ZGJB 3DTOA 2ZPFB 3HBLA 4FX3B 4F7NB 3QZ9B 2WEVB 2QF7A 2CYZB 4BCGB 4Y72B 4CFNB 2DPPB 4ELJA 2EUFA 2ZPGB 2BS4A 1GH6B 3A8GB 3MI9B 5DQWA 4ROCA 1QMZB 4EC9B 2BPMB 3X20B 3F5XB 4OR5B 3WVEB 4F7JB 5IDNB 3O0GD 1O9KA 2W99A 2IVXA 3MY1B 4KRDB 3TNHB 1F5QB 3HO8A 2IW6B 4JX6A 3A8MB 4YOOA 4BCMD 3WVDB 3MY5B 4ZGEB 1JOWA 2ZPEB 2WJ9A 2KR6A 5HQ0B 1AD6A 2UZEB 1UNGD 2QDJA 2X1NB 4OB0B 4BY7X 4QSHA 1VYWB 4EONB 4F6UB 4BCIB 2WXVB 2IW9B 4EOIB 4M6VA 1AISB 1D3UB 1H27B 5DQVA 4G6LB 4CFXB 1H1QB 2C6TB 4LOCA 4BCQB 2W9ZA 1H4LD 3QXEB 3B57A 4BCHB 2DXCB 4OGRB 5LQFB 2LW4A 4CXAB 4EOPB 4HNUA 1OL1B 5HBEB 1OKVB 2UZDB 4RODA 4EOKB 1UNLD 4CFUB 4CFMB 3BHUB 3BG3A 1QLBA 2DXBB 1FKMA 4OB1B 4TTHA 2CZ6B 1OL2B 1JSTB 4EOJB 3BLQB 1V29B 2B9RA 5ICPB
chains in the Genus database with same CATH topology
1QMZB 3DDQB 1JKWA 3TN8B 4BCMB 4CFWB 4F6SB 4EC9B 4EORB 2BPMB 4BCFB 3F5XB 3EJ1B 4OR5B 4EOLB 3TNWB 4F7JB 1W98B 5IDNB 4BCQD 1VINA 3O0GD 2C5VB 4IMYB 1O9KA 2W99A 2C5OB 2W96A 2IVXA 4ELLA 3MY1B 4BCPB 4KRDB 1XO2A 1H1PB 1G3NC 3BHTB 2JGZB 2CCIB 3TNHB 3EIDB 4EC8B 1F5QB 1GUXA 1GY3B 4BCNB 2IW6B 3DOGB 4YOOA 4BCMD 2I40B 3MY5B 5EFQB 1JOWA 1OI9B 1OKWB 1ZP2A 2W9FA 3M03A 3RGFB 1P5EB 2I53A 5CEIB 2PHGA 2WHBB 2IW8B 3BLHB 3DDPB 4CFUD 1OGUB 5HQ0B 4II5B 3K7AM 4YOSA 1AD6A 2UZEB 1UNGD 3BLRB 4YC3B 2QDJA 2X1NB 4YOZA 1VYWB 5IF1B 4EONB 2C4GB 4F6UB 4BCIB 1E9HB 2WXVB 2IW9B 4EOIB 4F7SB 1H24B 1H25B 3H4CA 1AISB 5HVYB 1UNHD 1FINB 2PK2A 1BU2A 1TFBA 5HBHB 2C5XB 4CFVB 2BKZB 2UZBB 4BCKB 1D3UB 1VOLA 2PMIB 4EOQB 2UZLB 1H27B 3TNIB 3MIAB 4CRLB 4G6LB 4CFXB 2WMAB 1H1QB 1H28B 1OIYB 1JSUB 2C6TB 2PK9B 5BNJB 3EOCB 4BCQB 2R7GA 4KRCB 2W9ZA 1H4LD 5HBJB 1KXUA 2W2HA 5IDPB 4EOSB 4BCOB 5CYIB 2UUEB 1H1RB 1PKDB 3POMA 1OIUB 4I3ZB 4NSTB 5I5ZB 1URCB 4BCHB 2CCHB 1GUXB 4F7LB 4OGRB 3G33B 4EOOB 4CXAB 1N4MA 2F2CA 4EOPB 4BCND 5L2WB 5LQFB 2WIPB 1OL1B 2G9XB 5LMKB 4UN0A 5HBEB 1OKVB 5ACBA 4FX3B 2UZDB 3LQ5B 2CJMB 3QHRB 4F7NB 4EOKB 2V22B 4RODA 2WPAB 1UNLD 4CFUB 4CFMB 3BHUB 2WEVB 5ICPB 4F6WB 1O9KB 4BCGB 1H26B 4Y72B 1H1SB 4BCJB 4EOMB 4F70B 4TTHA 4CFNB 1OL2B 4ELJA 2C5NB 1JSTB 2WMBB 5FGKB 2EUFA 3BHVB 5HNBB 4EOJB 3BLQB 1C9BA 1GH6B 3QHWB 4ROEA 3MI9B 4ROCA 2WFYB 2B9RA 2WIHB 1FVVB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1QMZ B;  3DDQ B;  1JKW A;  3TN8 B;  4BCM B;  4CFW B;  4F6S B;  4EC9 B;  4EOR B;  2BPM B;  4BCF B;  3F5X B;  3EJ1 B;  4OR5 B;  4EOL B;  3TNW B;  4F7J B;  1W98 B;  5IDN B;  4BCQ D;  1VIN A;  3O0G D;  2C5V B;  4IMY B;  1O9K A;  2W99 A;  2C5O B;  2W96 A;  2IVX A;  4ELL A;  3MY1 B;  4BCP B;  4KRD B;  1XO2 A;  1H1P B;  1G3N C;  3BHT B;  2JGZ B;  2CCI B;  3TNH B;  3EID B;  4EC8 B;  1F5Q B;  1GUX A;  1GY3 B;  4BCN B;  2IW6 B;  3DOG B;  4YOO A;  4BCM D;  2I40 B;  3MY5 B;  5EFQ B;  1JOW A;  1OI9 B;  1OKW B;  1ZP2 A;  2W9F A;  3M03 A;  3RGF B;  1P5E B;  2I53 A;  5CEI B;  2PHG A;  2WHB B;  2IW8 B;  3BLH B;  3DDP B;  4CFU D;  1OGU B;  5HQ0 B;  4II5 B;  3K7A M;  4YOS A;  1AD6 A;  2UZE B;  1UNG D;  3BLR B;  4YC3 B;  2QDJ A;  2X1N B;  4YOZ A;  1VYW B;  5IF1 B;  4EON B;  2C4G B;  4F6U B;  4BCI B;  1E9H B;  2WXV B;  2IW9 B;  4EOI B;  4F7S B;  1H24 B;  1H25 B;  3H4C A;  1AIS B;  5HVY B;  1UNH D;  1FIN B;  2PK2 A;  1BU2 A;  1TFB A;  5HBH B;  2C5X B;  4CFV B;  2BKZ B;  2UZB B;  4BCK B;  1D3U B;  1VOL A;  2PMI B;  4EOQ B;  2UZL B;  1H27 B;  3TNI B;  3MIA B;  4CRL B;  4G6L B;  4CFX B;  2WMA B;  1H1Q B;  1H28 B;  1OIY B;  1JSU B;  2C6T B;  2PK9 B;  5BNJ B;  3EOC B;  4BCQ B;  2R7G A;  4KRC B;  2W9Z A;  1H4L D;  5HBJ B;  1KXU A;  2W2H A;  5IDP B;  4EOS B;  4BCO B;  5CYI B;  2UUE B;  1H1R B;  1PKD B;  3POM A;  1OIU B;  4I3Z B;  4NST B;  5I5Z B;  1URC B;  4BCH B;  2CCH B;  1GUX B;  4F7L B;  4OGR B;  3G33 B;  4EOO B;  4CXA B;  1N4M A;  2F2C A;  4EOP B;  4BCN D;  5L2W B;  5LQF B;  2WIP B;  1OL1 B;  2G9X B;  5LMK B;  4UN0 A;  5HBE B;  1OKV B;  5ACB A;  4FX3 B;  2UZD B;  3LQ5 B;  2CJM B;  3QHR B;  4F7N B;  4EOK B;  2V22 B;  4ROD A;  2WPA B;  1UNL D;  4CFU B;  4CFM B;  3BHU B;  2WEV B;  5ICP B;  4F6W B;  1O9K B;  4BCG B;  1H26 B;  4Y72 B;  1H1S B;  4BCJ B;  4EOM B;  4F70 B;  4TTH A;  4CFN B;  1OL2 B;  4ELJ A;  2C5N B;  1JST B;  2WMB B;  5FGK B;  2EUF A;  3BHV B;  5HNB B;  4EOJ B;  3BLQ B;  1C9B A;  1GH6 B;  3QHW B;  4ROE A;  3MI9 B;  4ROC A;  2WFY B;  2B9R A;  2WIH B;  1FVV B; 
#chains in the Genus database with same CATH topology
 3DDQ B;  3TN8 B;  4BCM B;  4F6S B;  3BG9 A;  1UGQ B;  3A8O B;  3VYH B;  4BCQ D;  4HNT A;  2C5V B;  4IMY B;  2DD5 B;  2C5O B;  2W96 A;  4Z6Y A;  1G3N C;  2JGZ B;  4MIM A;  3EID B;  1GY3 B;  1GUX A;  2DD4 B;  2CZ0 B;  2ZZD B;  1OKW B;  1ZP2 A;  2W9F A;  1P5E B;  5CEI B;  2WHB B;  2IW8 B;  4CFU D;  4FM4 B;  1OGU B;  4YOS A;  3DL1 A;  4YOZ A;  2C4G B;  1E9H B;  3H4C A;  2PK2 A;  1TFB A;  5HBH B;  2C5X B;  4NC6 A;  4OB2 B;  1H28 B;  1OIY B;  2ZCF B;  3GTM S;  2CZ1 B;  4KRC B;  3PO3 S;  4EOS B;  2PJQ A;  4BCO B;  5CYI B;  1OIU B;  3QWL A;  5L2W B;  4ZGD B;  2F2C A;  2WIP B;  2G9X B;  2G77 A;  5EJC A;  5ACB A;  1E7P A;  2DME A;  4OB3 B;  3QHR B;  2V22 B;  2WPA B;  4BY1 X;  4F6W B;  2QQ8 A;  4BCJ B;  4F70 B;  5FGK B;  2WMB B;  2IN3 A;  5HNB B;  1C9B A;  4HL4 A;  3QHW B;  2WFY B;  1JKW A;  3VYG B;  4EOR B;  4BCF B;  4JX5 A;  1TD6 A;  3EJ1 B;  2AHJ B;  3TNW B;  3NDQ A;  1W98 B;  3BG5 A;  2BS2 A;  3X26 B;  4BCP B;  1H1P B;  3BHT B;  2CCI B;  2QDY B;  4MFD A;  4BCN B;  3DOG B;  2I40 B;  3X24 B;  3DDP B;  2ZPH B;  4AKH A;  3BLR B;  4YC3 B;  3A8H B;  5IF1 B;  4BBS M;  1H24 B;  3TW6 A;  1H25 B;  3KHI A;  5HVY B;  1FIN B;  1BU2 A;  3HB9 A;  2KMG A;  4BCK B;  2PMI B;  4BBR M;  3MIA B;  3QYE A;  2PK9 B;  3TW7 A;  5BNJ B;  2QFZ A;  3VKH A;  5HBJ B;  3VKG A;  4HNV A;  1AHJ B;  2UUE B;  1H1R B;  4NST B;  4I3Z B;  5IHY A;  2CCH B;  1GUX B;  3QYG B;  3X25 B;  4F7L B;  1N4M A;  4BCN D;  5LMK B;  4HLQ A;  2D0Q B;  3LQ5 B;  2CJM B;  4AKG A;  1O9K B;  1H26 B;  1H1S B;  2CZ7 B;  4EOM B;  3HZJ A;  2C5N B;  3BHV B;  3X28 B;  4AKI A;  4BXX X;  4ROE A;  2WIH B;  1FVV B;  2BS3 A;  4CFW B;  4EOL B;  1VIN A;  2ZPI B;  4ELL A;  3DJB A;  1UGP B;  1XO2 A;  4EC8 B;  2ZPB B;  1IRE B;  5EFQ B;  1OI9 B;  3M03 A;  3RGF B;  1UGS B;  2I53 A;  2PHG A;  3BLH B;  1ENW A;  3QYB A;  4II5 B;  3K7A M;  4F7S B;  4AI6 A;  3QYH B;  1UNH D;  4MFE A;  4CFV B;  2BKZ B;  3QZ5 B;  2UZB B;  1VOL A;  4EOQ B;  2UZL B;  3TNI B;  4CRL B;  1UGR B;  2WMA B;  1JSU B;  3EOC B;  2QGS A;  2R7G A;  1KXU A;  2W2H A;  5IDP B;  3POM A;  1PKD B;  4JX4 A;  5I5Z B;  1URC B;  3HHT B;  3G33 B;  4EOO B;  3A8L B;  4UN0 A;  4ZGJ B;  3DTO A;  2ZPF B;  3HBL A;  4FX3 B;  4F7N B;  3QZ9 B;  2WEV B;  2QF7 A;  2CYZ B;  4BCG B;  4Y72 B;  4CFN B;  2DPP B;  4ELJ A;  2EUF A;  2ZPG B;  2BS4 A;  1GH6 B;  3A8G B;  3MI9 B;  5DQW A;  4ROC A;  1QMZ B;  4EC9 B;  2BPM B;  3X20 B;  3F5X B;  4OR5 B;  3WVE B;  4F7J B;  5IDN B;  3O0G D;  1O9K A;  2W99 A;  2IVX A;  3MY1 B;  4KRD B;  3TNH B;  1F5Q B;  3HO8 A;  2IW6 B;  4JX6 A;  3A8M B;  4YOO A;  4BCM D;  3WVD B;  3MY5 B;  4ZGE B;  1JOW A;  2ZPE B;  2WJ9 A;  2KR6 A;  5HQ0 B;  1AD6 A;  2UZE B;  1UNG D;  2QDJ A;  2X1N B;  4OB0 B;  4BY7 X;  4QSH A;  1VYW B;  4EON B;  4F6U B;  4BCI B;  2WXV B;  2IW9 B;  4EOI B;  4M6V A;  1AIS B;  1D3U B;  1H27 B;  5DQV A;  4G6L B;  4CFX B;  1H1Q B;  2C6T B;  4LOC A;  4BCQ B;  2W9Z A;  1H4L D;  3QXE B;  3B57 A;  4BCH B;  2DXC B;  4OGR B;  5LQF B;  2LW4 A;  4CXA B;  4EOP B;  4HNU A;  1OL1 B;  5HBE B;  1OKV B;  2UZD B;  4ROD A;  4EOK B;  1UNL D;  4CFU B;  4CFM B;  3BHU B;  3BG3 A;  1QLB A;  2DXB B;  1FKM A;  4OB1 B;  4TTH A;  2CZ6 B;  1OL2 B;  1JST B;  4EOJ B;  3BLQ B;  1V29 B;  2B9R A;  5ICP B; 
#chains in the Genus database with same CATH homology
 1QMZ B;  3DDQ B;  1JKW A;  3TN8 B;  4BCM B;  4CFW B;  4F6S B;  4EC9 B;  4EOR B;  2BPM B;  4BCF B;  3F5X B;  3EJ1 B;  4OR5 B;  4EOL B;  3TNW B;  4F7J B;  1W98 B;  5IDN B;  4BCQ D;  1VIN A;  3O0G D;  2C5V B;  4IMY B;  1O9K A;  2W99 A;  2C5O B;  2W96 A;  2IVX A;  4ELL A;  3MY1 B;  4BCP B;  4KRD B;  1XO2 A;  1H1P B;  1G3N C;  3BHT B;  2JGZ B;  2CCI B;  3TNH B;  3EID B;  4EC8 B;  1F5Q B;  1GUX A;  1GY3 B;  4BCN B;  2IW6 B;  3DOG B;  4YOO A;  4BCM D;  2I40 B;  3MY5 B;  5EFQ B;  1JOW A;  1OI9 B;  1OKW B;  1ZP2 A;  2W9F A;  3M03 A;  3RGF B;  1P5E B;  2I53 A;  5CEI B;  2PHG A;  2WHB B;  2IW8 B;  3BLH B;  3DDP B;  4CFU D;  1OGU B;  5HQ0 B;  4II5 B;  3K7A M;  4YOS A;  1AD6 A;  2UZE B;  1UNG D;  3BLR B;  4YC3 B;  2QDJ A;  2X1N B;  4YOZ A;  1VYW B;  5IF1 B;  4EON B;  2C4G B;  4F6U B;  4BCI B;  1E9H B;  2WXV B;  2IW9 B;  4EOI B;  4F7S B;  1H24 B;  1H25 B;  3H4C A;  1AIS B;  5HVY B;  1UNH D;  1FIN B;  2PK2 A;  1BU2 A;  1TFB A;  5HBH B;  2C5X B;  4CFV B;  2BKZ B;  2UZB B;  4BCK B;  1D3U B;  1VOL A;  2PMI B;  4EOQ B;  2UZL B;  1H27 B;  3TNI B;  3MIA B;  4CRL B;  4G6L B;  4CFX B;  2WMA B;  1H1Q B;  1H28 B;  1OIY B;  1JSU B;  2C6T B;  2PK9 B;  5BNJ B;  3EOC B;  4BCQ B;  2R7G A;  4KRC B;  2W9Z A;  1H4L D;  5HBJ B;  1KXU A;  2W2H A;  5IDP B;  4EOS B;  4BCO B;  5CYI B;  2UUE B;  1H1R B;  1PKD B;  3POM A;  1OIU B;  4I3Z B;  4NST B;  5I5Z B;  1URC B;  4BCH B;  2CCH B;  1GUX B;  4F7L B;  4OGR B;  3G33 B;  4EOO B;  4CXA B;  1N4M A;  2F2C A;  4EOP B;  4BCN D;  5L2W B;  5LQF B;  2WIP B;  1OL1 B;  2G9X B;  5LMK B;  4UN0 A;  5HBE B;  1OKV B;  5ACB A;  4FX3 B;  2UZD B;  3LQ5 B;  2CJM B;  3QHR B;  4F7N B;  4EOK B;  2V22 B;  4ROD A;  2WPA B;  1UNL D;  4CFU B;  4CFM B;  3BHU B;  2WEV B;  5ICP B;  4F6W B;  1O9K B;  4BCG B;  1H26 B;  4Y72 B;  1H1S B;  4BCJ B;  4EOM B;  4F70 B;  4TTH A;  4CFN B;  1OL2 B;  4ELJ A;  2C5N B;  1JST B;  2WMB B;  5FGK B;  2EUF A;  3BHV B;  5HNB B;  4EOJ B;  3BLQ B;  1C9B A;  1GH6 B;  3QHW B;  4ROE A;  3MI9 B;  4ROC A;  2WFY B;  2B9R A;  2WIH B;  1FVV B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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