5HBEB

Cdk8-cycc in complex with 8-[3-chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1h-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one
Total Genus 93

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
266
structure length
266
Chain Sequence
KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPP

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
TI1 (1-4)TII1 (-1-2)3H1 (5-7)AH8 (155-166)AH1 (9-14)3H2 (188-190)AH2 (18-30)AH3 (34-55)AH13 (249-256)3H3 (246-248)TI3 (120-123)AH4 (59-75)AH5 (83-97)TI2 (77-80)TIV1 (78-81)TVIII1 (79-82)AH6 (105-120)TI4 (121-124)AH12 (224-243)AH9 (169-184)AH10 (194-209)AH11 (213-219)AH7 (132-146)EMPTYTI'1 (146-149)Updating...
connected with : NaN
molecule tags Transferase
source organism Homo sapiens
publication title Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
pubmed doi rcsb
molecule keywords Cyclin-dependent kinase 8
total genus 93
structure length 266
sequence length 266
ec nomenclature
pdb deposition date 2015-12-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00134 Cyclin_N Cyclin, N-terminal domain
B PF16899 Cyclin_C_2 Cyclin C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 5hbeB02
1.10.472.10 Mainly Alpha Orthogonal Bundle Cyclin A; domain 1 Cyclin-like 5hbeB01
5HBJB 1H26B 4FX3B 4BCKB 4CXAB 3DOGB 2EUFA 2C6TB 4F6SB 3TNWB 4ELJA 1H25B 1H1SB 4RODA 1P5EB 4CFMB 4EC8B 2W2HA 4YC3B 2WFYB 3POMA 4CFXB 5BNJB 1AISB 3LQ5B 4CFUB 5I5ZB 1E9HB 1H1PB 3H4CA 3QHWB 4EOSB 4II5B 4BCND 4TTHA 2B9RA 3TN8B 5L2WB 2UZBB 4F70B 3EJ1B 5LQFB 4Y72B 4I3ZB 4YOOA 4BCMD 1OL2B 2CJMB 4CRLB 2W96A 2V22B 5CEIB 4EONB 2C5OB 1KXUA 1H28B 1UNLD 1VYWB 3K7AM 1FINB 4EOMB 4EOLB 4BCIB 2W9ZA 4EOPB 3F5XB 5HBEB 1N4MA 3MI9B 4YOSA 4CFWB 4BCNB 1OIYB 1BU2A 4BCGB 2W9FA 1JOWA 4EC9B 2CCIB 2PHGA 2WXVB 2IVXA 1H1RB 5HVYB 1UNHD 4OGRB 4BCMB 2I40B 1QMZB 4ROEA 2UZDB 2WMBB 3EOCB 4EOKB 4NSTB 5ACBA 3TNIB 1OGUB 4BCFB 3BLRB 4KRCB 4EOOB 4EOJB 5CYIB 2JGZB 2C5VB 2IW8B 4F6WB 1G3NC 1O9KB 1H27B 1JKWA 5FGKB 4BCJB 2X1NB 4BCOB 3EIDB 1H1QB 4F7SB 4EORB 3MIAB 1XO2A 2WEVB 5HQ0B 4F7NB 2C5XB 5IF1B 1VINA 2IW9B 1AD6A 3M03A 2WPAB 2PK9B 2CCHB 1H4LD 1OKWB 1O9KA 3G33B 1FVVB 4IMYB 1D3UB 2WIPB 4YOZA 1F5QB 1VOLA 2PK2A 2UZLB 1GY3B 3BLQB 3DDPB 2G9XB 1URCB 4BCHB 1OL1B 4F7LB 1GUXA 4F6UB 4BCPB 1ZP2A 3BHTB 3BHUB 2UUEB 2F2CA 1H24B 4BCQD 2WMAB 2C5NB 1C9BA 2W99A 2C4GB 5EFQB 1W98B 1JSTB 2BKZB 4UN0A 4EOQB 4F7JB 3BLHB 5LMKB 3RGFB 4CFVB 2IW6B 1OKVB 5ICPB 5IDPB 2BPMB 1UNGD 3BHVB 3MY1B 1OIUB 3QHRB 1GUXB 2WHBB 5HNBB 4CFUD 3O0GD 1GH6B 3MY5B 4KRDB 4CFNB 5HBHB 4G6LB 4EOIB 2PMIB 2UZEB 4ELLA 2WIHB 1JSUB 5IDNB 2QDJA 3TNHB 1PKDB 4ROCA 3DDQB 4BCQB 1OI9B 2R7GA 1TFBA 2I53A 4OR5B
chains in the Genus database with same CATH superfamily
4FX3B 3VYGB 4CXAB 3TNWB 4CFMB 3HB9A 2ZPGB 2WFYB 3DL1A 4CFXB 4CFUB 4II5B 3X20B 4TTHA 2QGSA 3TN8B 5L2WB 1UGQB 4YOOA 4CRLB 2W96A 2V22B 2QQ8A 4EONB 1H28B 4NC6A 1VYWB 4EOLB 4ZGDB 3GTMS 3X24B 4BCIB 2W9ZA 3QZ5B 4EOPB 2QDYB 2ZPIB 4BCNB 1OIYB 3QXEB 3A8LB 4EC9B 1UGSB 2WXVB 5EJCA 4BCMB 2ZPEB 4NSTB 3BLRB 4EOOB 4BCJB 2X1NB 2PJQA 1H1QB 3MIAB 2WEVB 5HQ0B 2IW9B 3G33B 4BXXX 4YOZA 2QF7A 2G9XB 4HNTA 1OL1B 4BCPB 2UUEB 2F2CA 1JSTB 2BKZB 3RGFB 3BG9A 1OKVB 5ICPB 2BPMB 3A8GB 3MY1B 4AKHA 3O0GD 4JX6A 4CFNB 5HBHB 4BY7X 5IDNB 4ROCA 1PKDB 3A8MB 3QYBA 3X28B 4BCQB 5HBJB 2EUFA 4MIMA 4ELJA 5IHYA 1H25B 1H1SB 2W2HA 2AHJB 2KMGA 1AISB 3LQ5B 5I5ZB 1H1PB 4EOSB 4FM4B 2UZBB 5LQFB 4I3ZB 2CJMB 5CEIB 2C5OB 1UNLD 4HLQA 2KR6A 3K7AM 1IREB 4MFDA 2DPPB 4YOSA 4BCGB 1JOWA 2WJ9A 2CYZB 5HVYB 4M6VA 3HHTB 2WMBB 4EOKB 5ACBA 1OGUB 3WVDB 4EOJB 1O9KB 1H27B 1TD6A 4HNUA 1XO2A 3X25B 5IF1B 1VINA 2ZPFB 3VYHB 2G77A 3M03A 4HNVA 2PK9B 4BY1X 1D3UB 4IMYB 1O9KA 1GY3B 3DDPB 2DXBB 1GUXA 2WMAB 4EOQB 2C4GB 1W98B 4OB3B 4UN0A 3VKGA 2WHBB 4BBSM 4CFUD 1UGRB 4Z6YA 4AKIA 2PMIB 2UZEB 4ELLA 1OI9B 2R7GA 4OR5B 3QYHB 3DOGB 2C6TB 2LW4A 4RODA 4EC8B 4YC3B 3POMA 1E9HB 4BCND 1E7PA 2D0QB 4BCMD 2DD5B 3DTOA 3QYGB 1UGPB 3WVEB 3VKHA 3HZJA 5HBEB 3MI9B 3A8HB 4CFWB 3QWLA 1BU2A 2CCIB 1QLBA 4OGRB 2ZCFB 2I40B 1QMZB 2UZDB 3PO3S 4BCFB 4KRCB 2CZ7B 2C5VB 2IW8B 4MFEA 4F6WB 1G3NC 5FGKB 4JX5A 3B57A 2CZ1B 2WPAB 2CCHB 1H4LD 1OKWB 1FVVB 5DQWA 2WIPB 1F5QB 3BG3A 1VOLA 2DD4B 2PK2A 2UZLB 5DQVA 1URCB 4F7LB 4F6UB 1ZP2A 1AHJB 3BHUB 4BCQD 1C9BA 5EFQB 4F7JB 4CFVB 4HL4A 4ZGJB 2QFZA 3BHVB 1FKMA 1OIUB 1GUXB 2CZ0B 4KRDB 1V29B 2ZPHB 4EOIB 3DJBA 3HO8A 2WIHB 1JSUB 3NDQA 3TNHB 3DDQB 3QZ9B 1TFBA 2I53A 1H26B 4BCKB 3HBLA 2BS4A 4F6SB 1P5EB 4ZGEB 5BNJB 3H4CA 3QHWB 2B9RA 3EJ1B 4Y72B 1OL2B 4BBRM 1KXUA 2ZZDB 4QSHA 1FINB 4EOMB 1ENWA 3F5XB 1N4MA 4OB1B 2W9FA 2PHGA 2IVXA 1H1RB 1UNHD 4JX4A 2BS3A 3A8OB 2ZPBB 3QYEA 4ROEA 3EOCB 4LOCA 3TNIB 5CYIB 2JGZB 2DMEA 2BS2A 1JKWA 4BCOB 3EIDB 4F7SB 4AI6A 4EORB 3KHIA 3TW7A 4F7NB 2C5XB 1AD6A 2CZ6B 3TW6A 3X26B 3BLQB 4BCHB 3BG5A 3BHTB 1H24B 4OB0B 2C5NB 2W99A 5LMKB 3BLHB 2IW6B 4AKGA 2DXCB 5IDPB 1UNGD 3QHRB 5HNBB 2IN3A 1GH6B 3MY5B 4OB2B 4G6LB 2QDJA 4F70B
chains in the Genus database with same CATH topology
5HBJB 1H26B 4FX3B 4BCKB 4CXAB 3DOGB 2EUFA 2C6TB 4F6SB 3TNWB 4ELJA 1H25B 1H1SB 4RODA 1P5EB 4CFMB 4EC8B 2W2HA 4YC3B 2WFYB 3POMA 4CFXB 5BNJB 1AISB 3LQ5B 4CFUB 5I5ZB 1E9HB 1H1PB 3H4CA 3QHWB 4EOSB 4II5B 4BCND 4TTHA 2B9RA 3TN8B 5L2WB 2UZBB 4F70B 3EJ1B 5LQFB 4Y72B 4I3ZB 4YOOA 4BCMD 1OL2B 2CJMB 4CRLB 2W96A 2V22B 5CEIB 4EONB 2C5OB 1KXUA 1H28B 1UNLD 1VYWB 3K7AM 1FINB 4EOMB 4EOLB 4BCIB 2W9ZA 4EOPB 3F5XB 5HBEB 1N4MA 3MI9B 4YOSA 4CFWB 4BCNB 1OIYB 1BU2A 4BCGB 2W9FA 1JOWA 4EC9B 2CCIB 2PHGA 2WXVB 2IVXA 1H1RB 5HVYB 1UNHD 4OGRB 4BCMB 2I40B 1QMZB 4ROEA 2UZDB 2WMBB 3EOCB 4EOKB 4NSTB 5ACBA 3TNIB 1OGUB 4BCFB 3BLRB 4KRCB 4EOOB 4EOJB 5CYIB 2JGZB 2C5VB 2IW8B 4F6WB 1G3NC 1O9KB 1H27B 1JKWA 5FGKB 4BCJB 2X1NB 4BCOB 3EIDB 1H1QB 4F7SB 4EORB 3MIAB 1XO2A 2WEVB 5HQ0B 4F7NB 2C5XB 5IF1B 1VINA 2IW9B 1AD6A 3M03A 2WPAB 2PK9B 2CCHB 1H4LD 1OKWB 1O9KA 3G33B 1FVVB 4IMYB 1D3UB 2WIPB 4YOZA 1F5QB 1VOLA 2PK2A 2UZLB 1GY3B 3BLQB 3DDPB 2G9XB 1URCB 4BCHB 1OL1B 4F7LB 1GUXA 4F6UB 4BCPB 1ZP2A 3BHTB 3BHUB 2UUEB 2F2CA 1H24B 4BCQD 2WMAB 2C5NB 1C9BA 2W99A 2C4GB 5EFQB 1W98B 1JSTB 2BKZB 4UN0A 4EOQB 4F7JB 3BLHB 5LMKB 3RGFB 4CFVB 2IW6B 1OKVB 5ICPB 5IDPB 2BPMB 1UNGD 3BHVB 3MY1B 1OIUB 3QHRB 1GUXB 2WHBB 5HNBB 4CFUD 3O0GD 1GH6B 3MY5B 4KRDB 4CFNB 5HBHB 4G6LB 4EOIB 2PMIB 2UZEB 4ELLA 2WIHB 1JSUB 5IDNB 2QDJA 3TNHB 1PKDB 4ROCA 3DDQB 4BCQB 1OI9B 2R7GA 1TFBA 2I53A 4OR5B
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5HBJ B;  1H26 B;  4FX3 B;  4BCK B;  4CXA B;  3DOG B;  2EUF A;  2C6T B;  4F6S B;  3TNW B;  4ELJ A;  1H25 B;  1H1S B;  4ROD A;  1P5E B;  4CFM B;  4EC8 B;  2W2H A;  4YC3 B;  2WFY B;  3POM A;  4CFX B;  5BNJ B;  1AIS B;  3LQ5 B;  4CFU B;  5I5Z B;  1E9H B;  1H1P B;  3H4C A;  3QHW B;  4EOS B;  4II5 B;  4BCN D;  4TTH A;  2B9R A;  3TN8 B;  5L2W B;  2UZB B;  4F70 B;  3EJ1 B;  5LQF B;  4Y72 B;  4I3Z B;  4YOO A;  4BCM D;  1OL2 B;  2CJM B;  4CRL B;  2W96 A;  2V22 B;  5CEI B;  4EON B;  2C5O B;  1KXU A;  1H28 B;  1UNL D;  1VYW B;  3K7A M;  1FIN B;  4EOM B;  4EOL B;  4BCI B;  2W9Z A;  4EOP B;  3F5X B;  5HBE B;  1N4M A;  3MI9 B;  4YOS A;  4CFW B;  4BCN B;  1OIY B;  1BU2 A;  4BCG B;  2W9F A;  1JOW A;  4EC9 B;  2CCI B;  2PHG A;  2WXV B;  2IVX A;  1H1R B;  5HVY B;  1UNH D;  4OGR B;  4BCM B;  2I40 B;  1QMZ B;  4ROE A;  2UZD B;  2WMB B;  3EOC B;  4EOK B;  4NST B;  5ACB A;  3TNI B;  1OGU B;  4BCF B;  3BLR B;  4KRC B;  4EOO B;  4EOJ B;  5CYI B;  2JGZ B;  2C5V B;  2IW8 B;  4F6W B;  1G3N C;  1O9K B;  1H27 B;  1JKW A;  5FGK B;  4BCJ B;  2X1N B;  4BCO B;  3EID B;  1H1Q B;  4F7S B;  4EOR B;  3MIA B;  1XO2 A;  2WEV B;  5HQ0 B;  4F7N B;  2C5X B;  5IF1 B;  1VIN A;  2IW9 B;  1AD6 A;  3M03 A;  2WPA B;  2PK9 B;  2CCH B;  1H4L D;  1OKW B;  1O9K A;  3G33 B;  1FVV B;  4IMY B;  1D3U B;  2WIP B;  4YOZ A;  1F5Q B;  1VOL A;  2PK2 A;  2UZL B;  1GY3 B;  3BLQ B;  3DDP B;  2G9X B;  1URC B;  4BCH B;  1OL1 B;  4F7L B;  1GUX A;  4F6U B;  4BCP B;  1ZP2 A;  3BHT B;  3BHU B;  2UUE B;  2F2C A;  1H24 B;  4BCQ D;  2WMA B;  2C5N B;  1C9B A;  2W99 A;  2C4G B;  5EFQ B;  1W98 B;  1JST B;  2BKZ B;  4UN0 A;  4EOQ B;  4F7J B;  3BLH B;  5LMK B;  3RGF B;  4CFV B;  2IW6 B;  1OKV B;  5ICP B;  5IDP B;  2BPM B;  1UNG D;  3BHV B;  3MY1 B;  1OIU B;  3QHR B;  1GUX B;  2WHB B;  5HNB B;  4CFU D;  3O0G D;  1GH6 B;  3MY5 B;  4KRD B;  4CFN B;  5HBH B;  4G6L B;  4EOI B;  2PMI B;  2UZE B;  4ELL A;  2WIH B;  1JSU B;  5IDN B;  2QDJ A;  3TNH B;  1PKD B;  4ROC A;  3DDQ B;  4BCQ B;  1OI9 B;  2R7G A;  1TFB A;  2I53 A;  4OR5 B; 
#chains in the Genus database with same CATH topology
 4FX3 B;  3VYG B;  4CXA B;  3TNW B;  4CFM B;  3HB9 A;  2ZPG B;  2WFY B;  3DL1 A;  4CFX B;  4CFU B;  4II5 B;  3X20 B;  4TTH A;  2QGS A;  3TN8 B;  5L2W B;  1UGQ B;  4YOO A;  4CRL B;  2W96 A;  2V22 B;  2QQ8 A;  4EON B;  1H28 B;  4NC6 A;  1VYW B;  4EOL B;  4ZGD B;  3GTM S;  3X24 B;  4BCI B;  2W9Z A;  3QZ5 B;  4EOP B;  2QDY B;  2ZPI B;  4BCN B;  1OIY B;  3QXE B;  3A8L B;  4EC9 B;  1UGS B;  2WXV B;  5EJC A;  4BCM B;  2ZPE B;  4NST B;  3BLR B;  4EOO B;  4BCJ B;  2X1N B;  2PJQ A;  1H1Q B;  3MIA B;  2WEV B;  5HQ0 B;  2IW9 B;  3G33 B;  4BXX X;  4YOZ A;  2QF7 A;  2G9X B;  4HNT A;  1OL1 B;  4BCP B;  2UUE B;  2F2C A;  1JST B;  2BKZ B;  3RGF B;  3BG9 A;  1OKV B;  5ICP B;  2BPM B;  3A8G B;  3MY1 B;  4AKH A;  3O0G D;  4JX6 A;  4CFN B;  5HBH B;  4BY7 X;  5IDN B;  4ROC A;  1PKD B;  3A8M B;  3QYB A;  3X28 B;  4BCQ B;  5HBJ B;  2EUF A;  4MIM A;  4ELJ A;  5IHY A;  1H25 B;  1H1S B;  2W2H A;  2AHJ B;  2KMG A;  1AIS B;  3LQ5 B;  5I5Z B;  1H1P B;  4EOS B;  4FM4 B;  2UZB B;  5LQF B;  4I3Z B;  2CJM B;  5CEI B;  2C5O B;  1UNL D;  4HLQ A;  2KR6 A;  3K7A M;  1IRE B;  4MFD A;  2DPP B;  4YOS A;  4BCG B;  1JOW A;  2WJ9 A;  2CYZ B;  5HVY B;  4M6V A;  3HHT B;  2WMB B;  4EOK B;  5ACB A;  1OGU B;  3WVD B;  4EOJ B;  1O9K B;  1H27 B;  1TD6 A;  4HNU A;  1XO2 A;  3X25 B;  5IF1 B;  1VIN A;  2ZPF B;  3VYH B;  2G77 A;  3M03 A;  4HNV A;  2PK9 B;  4BY1 X;  1D3U B;  4IMY B;  1O9K A;  1GY3 B;  3DDP B;  2DXB B;  1GUX A;  2WMA B;  4EOQ B;  2C4G B;  1W98 B;  4OB3 B;  4UN0 A;  3VKG A;  2WHB B;  4BBS M;  4CFU D;  1UGR B;  4Z6Y A;  4AKI A;  2PMI B;  2UZE B;  4ELL A;  1OI9 B;  2R7G A;  4OR5 B;  3QYH B;  3DOG B;  2C6T B;  2LW4 A;  4ROD A;  4EC8 B;  4YC3 B;  3POM A;  1E9H B;  4BCN D;  1E7P A;  2D0Q B;  4BCM D;  2DD5 B;  3DTO A;  3QYG B;  1UGP B;  3WVE B;  3VKH A;  3HZJ A;  5HBE B;  3MI9 B;  3A8H B;  4CFW B;  3QWL A;  1BU2 A;  2CCI B;  1QLB A;  4OGR B;  2ZCF B;  2I40 B;  1QMZ B;  2UZD B;  3PO3 S;  4BCF B;  4KRC B;  2CZ7 B;  2C5V B;  2IW8 B;  4MFE A;  4F6W B;  1G3N C;  5FGK B;  4JX5 A;  3B57 A;  2CZ1 B;  2WPA B;  2CCH B;  1H4L D;  1OKW B;  1FVV B;  5DQW A;  2WIP B;  1F5Q B;  3BG3 A;  1VOL A;  2DD4 B;  2PK2 A;  2UZL B;  5DQV A;  1URC B;  4F7L B;  4F6U B;  1ZP2 A;  1AHJ B;  3BHU B;  4BCQ D;  1C9B A;  5EFQ B;  4F7J B;  4CFV B;  4HL4 A;  4ZGJ B;  2QFZ A;  3BHV B;  1FKM A;  1OIU B;  1GUX B;  2CZ0 B;  4KRD B;  1V29 B;  2ZPH B;  4EOI B;  3DJB A;  3HO8 A;  2WIH B;  1JSU B;  3NDQ A;  3TNH B;  3DDQ B;  3QZ9 B;  1TFB A;  2I53 A;  1H26 B;  4BCK B;  3HBL A;  2BS4 A;  4F6S B;  1P5E B;  4ZGE B;  5BNJ B;  3H4C A;  3QHW B;  2B9R A;  3EJ1 B;  4Y72 B;  1OL2 B;  4BBR M;  1KXU A;  2ZZD B;  4QSH A;  1FIN B;  4EOM B;  1ENW A;  3F5X B;  1N4M A;  4OB1 B;  2W9F A;  2PHG A;  2IVX A;  1H1R B;  1UNH D;  4JX4 A;  2BS3 A;  3A8O B;  2ZPB B;  3QYE A;  4ROE A;  3EOC B;  4LOC A;  3TNI B;  5CYI B;  2JGZ B;  2DME A;  2BS2 A;  1JKW A;  4BCO B;  3EID B;  4F7S B;  4AI6 A;  4EOR B;  3KHI A;  3TW7 A;  4F7N B;  2C5X B;  1AD6 A;  2CZ6 B;  3TW6 A;  3X26 B;  3BLQ B;  4BCH B;  3BG5 A;  3BHT B;  1H24 B;  4OB0 B;  2C5N B;  2W99 A;  5LMK B;  3BLH B;  2IW6 B;  4AKG A;  2DXC B;  5IDP B;  1UNG D;  3QHR B;  5HNB B;  2IN3 A;  1GH6 B;  3MY5 B;  4OB2 B;  4G6L B;  2QDJ A;  4F70 B; 
#chains in the Genus database with same CATH homology
 5HBJ B;  1H26 B;  4FX3 B;  4BCK B;  4CXA B;  3DOG B;  2EUF A;  2C6T B;  4F6S B;  3TNW B;  4ELJ A;  1H25 B;  1H1S B;  4ROD A;  1P5E B;  4CFM B;  4EC8 B;  2W2H A;  4YC3 B;  2WFY B;  3POM A;  4CFX B;  5BNJ B;  1AIS B;  3LQ5 B;  4CFU B;  5I5Z B;  1E9H B;  1H1P B;  3H4C A;  3QHW B;  4EOS B;  4II5 B;  4BCN D;  4TTH A;  2B9R A;  3TN8 B;  5L2W B;  2UZB B;  4F70 B;  3EJ1 B;  5LQF B;  4Y72 B;  4I3Z B;  4YOO A;  4BCM D;  1OL2 B;  2CJM B;  4CRL B;  2W96 A;  2V22 B;  5CEI B;  4EON B;  2C5O B;  1KXU A;  1H28 B;  1UNL D;  1VYW B;  3K7A M;  1FIN B;  4EOM B;  4EOL B;  4BCI B;  2W9Z A;  4EOP B;  3F5X B;  5HBE B;  1N4M A;  3MI9 B;  4YOS A;  4CFW B;  4BCN B;  1OIY B;  1BU2 A;  4BCG B;  2W9F A;  1JOW A;  4EC9 B;  2CCI B;  2PHG A;  2WXV B;  2IVX A;  1H1R B;  5HVY B;  1UNH D;  4OGR B;  4BCM B;  2I40 B;  1QMZ B;  4ROE A;  2UZD B;  2WMB B;  3EOC B;  4EOK B;  4NST B;  5ACB A;  3TNI B;  1OGU B;  4BCF B;  3BLR B;  4KRC B;  4EOO B;  4EOJ B;  5CYI B;  2JGZ B;  2C5V B;  2IW8 B;  4F6W B;  1G3N C;  1O9K B;  1H27 B;  1JKW A;  5FGK B;  4BCJ B;  2X1N B;  4BCO B;  3EID B;  1H1Q B;  4F7S B;  4EOR B;  3MIA B;  1XO2 A;  2WEV B;  5HQ0 B;  4F7N B;  2C5X B;  5IF1 B;  1VIN A;  2IW9 B;  1AD6 A;  3M03 A;  2WPA B;  2PK9 B;  2CCH B;  1H4L D;  1OKW B;  1O9K A;  3G33 B;  1FVV B;  4IMY B;  1D3U B;  2WIP B;  4YOZ A;  1F5Q B;  1VOL A;  2PK2 A;  2UZL B;  1GY3 B;  3BLQ B;  3DDP B;  2G9X B;  1URC B;  4BCH B;  1OL1 B;  4F7L B;  1GUX A;  4F6U B;  4BCP B;  1ZP2 A;  3BHT B;  3BHU B;  2UUE B;  2F2C A;  1H24 B;  4BCQ D;  2WMA B;  2C5N B;  1C9B A;  2W99 A;  2C4G B;  5EFQ B;  1W98 B;  1JST B;  2BKZ B;  4UN0 A;  4EOQ B;  4F7J B;  3BLH B;  5LMK B;  3RGF B;  4CFV B;  2IW6 B;  1OKV B;  5ICP B;  5IDP B;  2BPM B;  1UNG D;  3BHV B;  3MY1 B;  1OIU B;  3QHR B;  1GUX B;  2WHB B;  5HNB B;  4CFU D;  3O0G D;  1GH6 B;  3MY5 B;  4KRD B;  4CFN B;  5HBH B;  4G6L B;  4EOI B;  2PMI B;  2UZE B;  4ELL A;  2WIH B;  1JSU B;  5IDN B;  2QDJ A;  3TNH B;  1PKD B;  4ROC A;  3DDQ B;  4BCQ B;  1OI9 B;  2R7G A;  1TFB A;  2I53 A;  4OR5 B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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