1F8UB

Crystal structure of mutant e202q of human acetylcholinesterase complexed with green mamba venom peptide fasciculin-ii
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ACETYLCHOLINESTERASE
publication title Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/toxin
total genus 12
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2000-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 1f8uB00
1HAJA 1IKCA 3VTSA 2MJ4A 2H7ZA 2MUPA 1NXBA 1CCQA 4DO8A 1KXIA 1L4WA 1CXOA 1ERAA 1NYSA 2PJYB 3NEQA 1V6PA 1S4YA 1NYUA 1KFHA 3NH7A 1CODA 2H64C 2MJ0A 4IYEA 1KS6A 1CHVS 1YWHA 4FAOE 4BIKB 2HLRA 4P7UA 1CDTA 1W6BA 1FF4A 2LCRA 5DO6A 1ONJA 2QJ9C 3U73U 1CXNA 1G6MA 4EY8B 1HAAA 2QJAC 1KBSA 1TFSA 2CTXA 2MJYA 3HH7A 2H64B 3NDSA 1JE9A 1IDHA 1IK8A 1HC9A 2BHIA 2MFAA 2ERAA 1NEAA 1RGJA 1F8UB 4BDTB 1ES7B 1NORA 1TGXA 2QC1A 4XJJA 1XT3A 2QJBC 2X8BB 1TXBA 4UY2C 1CDQA 1F94A 5DU1A 1REWC 3PLCA 2L03A 1RL5A 3U74U 1IDLA 3LAQU 2UWRA 1LXHA 1TXAA 2BTXA 4QTIU 1I02A 1B41B 1PLOA 1ZADA 1FSSB 1KBAA 4OM5A 1LSIA 2JVEA 4OM4A 1QKEA 1IDGA 2CCXA 1CRFA 2MHYA 1MR6A 1QKDA 2K3GA 2OFSA 1FASA 1KC4A 1M9ZA 1BXPA 2H62D 1ABTA 2JQPA 2GOOC 4HQPF 1CREA 3KFDE 2CDXA 2ABXA 3FEVA 1LX5B 3ERAA 1COEA 1FSCA 1CVOA 1LJZA 1IJCA 1KTZB 2H5FA 1DRSA 4FAOC 2H8UA 2LA1A 2H7ZB 5DZ5A 1KU6B 1NTXA 2GOOB 3BT2U 2J8BA 5IMYC 1FRAA 1KBTA 5IMTD 1IQ9A 1JBDA 2CRTA 2CRSA 2VLWA 3EVSC 1KL8A 1BTEA 3KFDI 2H62C 6EBXA 3EBXA 4RUDA 1CB9A 3BT1U 4LFTA 2I9BE 1CTXA 1LXGA 1ERGA 1IDIA 5EBXA 1UG4A 1CDRA 1FFJA 1H0JA 3QB4B 2FD6U 1CDSA 2UX2A 2L5SA 2MUOA 2HLQA 1NTNA 1HC9B 1QM7A 2NBTA 1HOYA 2N99A 4ZQYA 2PJYC 4AEAA 1MAHF 1VB0A 1JGKA
chains in the Genus database with same CATH superfamily
1HAJA 1IKCA 3VTSA 2MJ4A 2H7ZA 2MUPA 1NXBA 1CCQA 4DO8A 1KXIA 1L4WA 1CXOA 1ERAA 1NYSA 2PJYB 3NEQA 1V6PA 1S4YA 1NYUA 1KFHA 3NH7A 1CODA 2H64C 2MJ0A 4IYEA 1KS6A 1CHVS 1YWHA 4FAOE 4BIKB 2HLRA 4P7UA 1CDTA 1W6BA 1FF4A 2LCRA 5DO6A 1ONJA 2QJ9C 3U73U 1CXNA 1G6MA 4EY8B 1HAAA 2QJAC 1KBSA 1TFSA 2CTXA 2MJYA 3HH7A 2H64B 3NDSA 1JE9A 1IDHA 1IK8A 1HC9A 2BHIA 2MFAA 2ERAA 1NEAA 1RGJA 1F8UB 4BDTB 1ES7B 1NORA 1TGXA 2QC1A 4XJJA 1XT3A 2QJBC 2X8BB 1TXBA 4UY2C 1CDQA 1F94A 5DU1A 1REWC 3PLCA 2L03A 1RL5A 3U74U 1IDLA 3LAQU 2UWRA 1LXHA 1TXAA 2BTXA 4QTIU 1I02A 1B41B 1PLOA 1ZADA 1FSSB 1KBAA 4OM5A 1LSIA 2JVEA 4OM4A 1QKEA 1IDGA 2CCXA 4KSNA 2MHYA 1CRFA 1MR6A 1QKDA 2K3GA 2OFSA 1FASA 1KC4A 1M9ZA 1BXPA 2H62D 1ABTA 2JQPA 2GOOC 4HQPF 1CREA 3KFDE 2CDXA 2ABXA 3FEVA 1LX5B 3ERAA 1COEA 1FSCA 1CVOA 1LJZA 1IJCA 1KTZB 2H5FA 1DRSA 4FAOC 2H8UA 2LA1A 2H7ZB 5DZ5A 1KU6B 1NTXA 2GOOB 3BT2U 2J8BA 5IMYC 1FRAA 1KBTA 5IMTD 1IQ9A 1JBDA 2CRTA 2CRSA 2VLWA 3EVSC 1KL8A 1BTEA 3KFDI 2H62C 6EBXA 3EBXA 4RUDA 1CB9A 3BT1U 4LFTA 2I9BE 1CTXA 1LXGA 1ERGA 1IDIA 5EBXA 1UG4A 1CDRA 1FFJA 1H0JA 3QB4B 2FD6U 1CDSA 2UX2A 2L5SA 2MUOA 2HLQA 1NTNA 1HC9B 1QM7A 2NBTA 1HOYA 2N99A 4ZQYA 2PJYC 4AEAA 1MAHF 1VB0A 1JGKA
chains in the Genus database with same CATH topology
1HAJA 1IKCA 3VTSA 2MJ4A 2H7ZA 2MUPA 1NXBA 1CCQA 4DO8A 1KXIA 1L4WA 1CXOA 1ERAA 1NYSA 2PJYB 3NEQA 1V6PA 1S4YA 1NYUA 1KFHA 3NH7A 1CODA 2H64C 2MJ0A 4IYEA 1KS6A 1CHVS 1YWHA 4FAOE 4BIKB 2HLRA 4P7UA 1CDTA 1W6BA 1FF4A 2LCRA 5DO6A 1ONJA 2QJ9C 3U73U 1CXNA 1G6MA 4EY8B 1HAAA 2QJAC 1KBSA 1TFSA 2CTXA 2MJYA 3HH7A 2H64B 3NDSA 1JE9A 1IDHA 1IK8A 1HC9A 2BHIA 2MFAA 2ERAA 1NEAA 1RGJA 1F8UB 4BDTB 1ES7B 1NORA 1TGXA 2QC1A 4XJJA 1XT3A 2QJBC 2X8BB 1TXBA 4UY2C 1CDQA 1F94A 5DU1A 1REWC 3PLCA 2L03A 1RL5A 3U74U 1IDLA 3LAQU 2UWRA 1LXHA 1TXAA 2BTXA 4QTIU 1I02A 1B41B 1PLOA 1ZADA 1FSSB 1KBAA 4OM5A 1LSIA 2JVEA 4OM4A 1QKEA 1IDGA 2CCXA 4KSNA 2MHYA 1CRFA 1MR6A 1QKDA 2K3GA 2OFSA 1FASA 1KC4A 1M9ZA 1BXPA 2H62D 1ABTA 2JQPA 2GOOC 4HQPF 1CREA 3KFDE 2CDXA 2ABXA 3FEVA 1LX5B 3ERAA 1COEA 1FSCA 1CVOA 1LJZA 1IJCA 1KTZB 2H5FA 1DRSA 4FAOC 2H8UA 2LA1A 2H7ZB 5DZ5A 1KU6B 1NTXA 2GOOB 3BT2U 2J8BA 5IMYC 1FRAA 1KBTA 5IMTD 1IQ9A 1JBDA 2CRTA 2CRSA 2VLWA 3EVSC 1KL8A 1BTEA 3KFDI 2H62C 6EBXA 3EBXA 4RUDA 1CB9A 3BT1U 4LFTA 2I9BE 1CTXA 1LXGA 1ERGA 1IDIA 5EBXA 1UG4A 1CDRA 1FFJA 1H0JA 3QB4B 2FD6U 1CDSA 2UX2A 2L5SA 2MUOA 2HLQA 1NTNA 1HC9B 1QM7A 2NBTA 1HOYA 2N99A 4ZQYA 2PJYC 4AEAA 1MAHF 1VB0A 1JGKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HAJ A;  1IKC A;  3VTS A;  2MJ4 A;  2H7Z A;  2MUP A;  1NXB A;  1CCQ A;  4DO8 A;  1KXI A;  1L4W A;  1CXO A;  1ERA A;  1NYS A;  2PJY B;  3NEQ A;  1V6P A;  1S4Y A;  1NYU A;  1KFH A;  3NH7 A;  1COD A;  2H64 C;  2MJ0 A;  4IYE A;  1KS6 A;  1CHV S;  1YWH A;  4FAO E;  4BIK B;  2HLR A;  4P7U A;  1CDT A;  1W6B A;  1FF4 A;  2LCR A;  5DO6 A;  1ONJ A;  2QJ9 C;  3U73 U;  1CXN A;  1G6M A;  4EY8 B;  1HAA A;  2QJA C;  1KBS A;  1TFS A;  2CTX A;  2MJY A;  3HH7 A;  2H64 B;  3NDS A;  1JE9 A;  1IDH A;  1IK8 A;  1HC9 A;  2BHI A;  2MFA A;  2ERA A;  1NEA A;  1RGJ A;  1F8U B;  4BDT B;  1ES7 B;  1NOR A;  1TGX A;  2QC1 A;  4XJJ A;  1XT3 A;  2QJB C;  2X8B B;  1TXB A;  4UY2 C;  1CDQ A;  1F94 A;  5DU1 A;  1REW C;  3PLC A;  2L03 A;  1RL5 A;  3U74 U;  1IDL A;  3LAQ U;  2UWR A;  1LXH A;  1TXA A;  2BTX A;  4QTI U;  1I02 A;  1B41 B;  1PLO A;  1ZAD A;  1FSS B;  1KBA A;  4OM5 A;  1LSI A;  2JVE A;  4OM4 A;  1QKE A;  1IDG A;  2CCX A;  1CRF A;  2MHY A;  1MR6 A;  1QKD A;  2K3G A;  2OFS A;  1FAS A;  1KC4 A;  1M9Z A;  1BXP A;  2H62 D;  1ABT A;  2JQP A;  2GOO C;  4HQP F;  1CRE A;  3KFD E;  2CDX A;  2ABX A;  3FEV A;  1LX5 B;  3ERA A;  1COE A;  1FSC A;  1CVO A;  1LJZ A;  1IJC A;  1KTZ B;  2H5F A;  1DRS A;  4FAO C;  2H8U A;  2LA1 A;  2H7Z B;  5DZ5 A;  1KU6 B;  1NTX A;  2GOO B;  3BT2 U;  2J8B A;  5IMY C;  1FRA A;  1KBT A;  5IMT D;  1IQ9 A;  1JBD A;  2CRT A;  2CRS A;  2VLW A;  3EVS C;  1KL8 A;  1BTE A;  3KFD I;  2H62 C;  6EBX A;  3EBX A;  4RUD A;  1CB9 A;  3BT1 U;  4LFT A;  2I9B E;  1CTX A;  1LXG A;  1ERG A;  1IDI A;  5EBX A;  1UG4 A;  1CDR A;  1FFJ A;  1H0J A;  3QB4 B;  2FD6 U;  1CDS A;  2UX2 A;  2L5S A;  2MUO A;  2HLQ A;  1NTN A;  1HC9 B;  1QM7 A;  2NBT A;  1HOY A;  2N99 A;  4ZQY A;  2PJY C;  4AEA A;  1MAH F;  1VB0 A;  1JGK A; 
#chains in the Genus database with same CATH topology
 1HAJ A;  1IKC A;  3VTS A;  2MJ4 A;  2H7Z A;  2MUP A;  1NXB A;  1CCQ A;  4DO8 A;  1KXI A;  1L4W A;  1CXO A;  1ERA A;  1NYS A;  2PJY B;  3NEQ A;  1V6P A;  1S4Y A;  1NYU A;  1KFH A;  3NH7 A;  1COD A;  2H64 C;  2MJ0 A;  4IYE A;  1KS6 A;  1CHV S;  1YWH A;  4FAO E;  4BIK B;  2HLR A;  4P7U A;  1CDT A;  1W6B A;  1FF4 A;  2LCR A;  5DO6 A;  1ONJ A;  2QJ9 C;  3U73 U;  1CXN A;  1G6M A;  4EY8 B;  1HAA A;  2QJA C;  1KBS A;  1TFS A;  2CTX A;  2MJY A;  3HH7 A;  2H64 B;  3NDS A;  1JE9 A;  1IDH A;  1IK8 A;  1HC9 A;  2BHI A;  2MFA A;  2ERA A;  1NEA A;  1RGJ A;  1F8U B;  4BDT B;  1ES7 B;  1NOR A;  1TGX A;  2QC1 A;  4XJJ A;  1XT3 A;  2QJB C;  2X8B B;  1TXB A;  4UY2 C;  1CDQ A;  1F94 A;  5DU1 A;  1REW C;  3PLC A;  2L03 A;  1RL5 A;  3U74 U;  1IDL A;  3LAQ U;  2UWR A;  1LXH A;  1TXA A;  2BTX A;  4QTI U;  1I02 A;  1B41 B;  1PLO A;  1ZAD A;  1FSS B;  1KBA A;  4OM5 A;  1LSI A;  2JVE A;  4OM4 A;  1QKE A;  1IDG A;  2CCX A;  4KSN A;  2MHY A;  1CRF A;  1MR6 A;  1QKD A;  2K3G A;  2OFS A;  1FAS A;  1KC4 A;  1M9Z A;  1BXP A;  2H62 D;  1ABT A;  2JQP A;  2GOO C;  4HQP F;  1CRE A;  3KFD E;  2CDX A;  2ABX A;  3FEV A;  1LX5 B;  3ERA A;  1COE A;  1FSC A;  1CVO A;  1LJZ A;  1IJC A;  1KTZ B;  2H5F A;  1DRS A;  4FAO C;  2H8U A;  2LA1 A;  2H7Z B;  5DZ5 A;  1KU6 B;  1NTX A;  2GOO B;  3BT2 U;  2J8B A;  5IMY C;  1FRA A;  1KBT A;  5IMT D;  1IQ9 A;  1JBD A;  2CRT A;  2CRS A;  2VLW A;  3EVS C;  1KL8 A;  1BTE A;  3KFD I;  2H62 C;  6EBX A;  3EBX A;  4RUD A;  1CB9 A;  3BT1 U;  4LFT A;  2I9B E;  1CTX A;  1LXG A;  1ERG A;  1IDI A;  5EBX A;  1UG4 A;  1CDR A;  1FFJ A;  1H0J A;  3QB4 B;  2FD6 U;  1CDS A;  2UX2 A;  2L5S A;  2MUO A;  2HLQ A;  1NTN A;  1HC9 B;  1QM7 A;  2NBT A;  1HOY A;  2N99 A;  4ZQY A;  2PJY C;  4AEA A;  1MAH F;  1VB0 A;  1JGK A; 
#chains in the Genus database with same CATH homology
 1HAJ A;  1IKC A;  3VTS A;  2MJ4 A;  2H7Z A;  2MUP A;  1NXB A;  1CCQ A;  4DO8 A;  1KXI A;  1L4W A;  1CXO A;  1ERA A;  1NYS A;  2PJY B;  3NEQ A;  1V6P A;  1S4Y A;  1NYU A;  1KFH A;  3NH7 A;  1COD A;  2H64 C;  2MJ0 A;  4IYE A;  1KS6 A;  1CHV S;  1YWH A;  4FAO E;  4BIK B;  2HLR A;  4P7U A;  1CDT A;  1W6B A;  1FF4 A;  2LCR A;  5DO6 A;  1ONJ A;  2QJ9 C;  3U73 U;  1CXN A;  1G6M A;  4EY8 B;  1HAA A;  2QJA C;  1KBS A;  1TFS A;  2CTX A;  2MJY A;  3HH7 A;  2H64 B;  3NDS A;  1JE9 A;  1IDH A;  1IK8 A;  1HC9 A;  2BHI A;  2MFA A;  2ERA A;  1NEA A;  1RGJ A;  1F8U B;  4BDT B;  1ES7 B;  1NOR A;  1TGX A;  2QC1 A;  4XJJ A;  1XT3 A;  2QJB C;  2X8B B;  1TXB A;  4UY2 C;  1CDQ A;  1F94 A;  5DU1 A;  1REW C;  3PLC A;  2L03 A;  1RL5 A;  3U74 U;  1IDL A;  3LAQ U;  2UWR A;  1LXH A;  1TXA A;  2BTX A;  4QTI U;  1I02 A;  1B41 B;  1PLO A;  1ZAD A;  1FSS B;  1KBA A;  4OM5 A;  1LSI A;  2JVE A;  4OM4 A;  1QKE A;  1IDG A;  2CCX A;  4KSN A;  2MHY A;  1CRF A;  1MR6 A;  1QKD A;  2K3G A;  2OFS A;  1FAS A;  1KC4 A;  1M9Z A;  1BXP A;  2H62 D;  1ABT A;  2JQP A;  2GOO C;  4HQP F;  1CRE A;  3KFD E;  2CDX A;  2ABX A;  3FEV A;  1LX5 B;  3ERA A;  1COE A;  1FSC A;  1CVO A;  1LJZ A;  1IJC A;  1KTZ B;  2H5F A;  1DRS A;  4FAO C;  2H8U A;  2LA1 A;  2H7Z B;  5DZ5 A;  1KU6 B;  1NTX A;  2GOO B;  3BT2 U;  2J8B A;  5IMY C;  1FRA A;  1KBT A;  5IMT D;  1IQ9 A;  1JBD A;  2CRT A;  2CRS A;  2VLW A;  3EVS C;  1KL8 A;  1BTE A;  3KFD I;  2H62 C;  6EBX A;  3EBX A;  4RUD A;  1CB9 A;  3BT1 U;  4LFT A;  2I9B E;  1CTX A;  1LXG A;  1ERG A;  1IDI A;  5EBX A;  1UG4 A;  1CDR A;  1FFJ A;  1H0J A;  3QB4 B;  2FD6 U;  1CDS A;  2UX2 A;  2L5S A;  2MUO A;  2HLQ A;  1NTN A;  1HC9 B;  1QM7 A;  2NBT A;  1HOY A;  2N99 A;  4ZQY A;  2PJY C;  4AEA A;  1MAH F;  1VB0 A;  1JGK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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