1F8UB

Crystal structure of mutant e202q of human acetylcholinesterase complexed with green mamba venom peptide fasciculin-ii
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/toxin
molecule keywords ACETYLCHOLINESTERASE
publication title Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
pubmed doi rcsb
source organism Homo sapiens
total genus 12
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2000-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 1f8uB00
1NORA 2NBTA 1HC9A 1CDTA 1BXPA 1KC4A 1FRAA 1ERGA 1ABTA 1TFSA 5DZ5A 1VB0A 2CCXA 2MHYA 1LJZA 2HLQA 1V6PA 2QJAC 1CVOA 3U74U 2MUOA 1FASA 1IDIA 3EBXA 1BTEA 4BIKB 2JVEA 1FFJA 4BDTB 5EBXA 4P7UA 2GOOC 1IK8A 3QB4B 4HQPF 1REWC 1ES7B 4LFTA 1RGJA 3NEQA 1CXNA 1CCQA 1CDQA 1PLOA 3HH7A 1IDLA 4DO8A 1FSCA 1F8UB 3NDSA 1JBDA 1CHVS 1CODA 1NTNA 1CXOA 1KBSA 1IDGA 1KFHA 1IJCA 1CDSA 1QKEA 1DRSA 4IYEA 2VLWA 2MFAA 5IMTD 1CDRA 1IQ9A 1CREA 3PLCA 2L5SA 2K3GA 4OM4A 3KFDI 2CTXA 2ERAA 2MUPA 3U73U 1JGKA 2PJYB 1NYSA 1ONJA 2I9BE 1LSIA 1FF4A 1M9ZA 3NH7A 1W6BA 1COEA 1JE9A 2CDXA 1FSSB 4FAOE 1QKDA 5DO6A 5IMYC 1NYUA 2CRTA 2X8BB 3BT2U 1NEAA 2JQPA 4QTIU 1MAHF 2H62C 2UX2A 1HAJA 1UG4A 2BTXA 1B41B 2HLRA 1KU6B 2ABXA 5DU1A 2MJYA 3LAQU 2H7ZA 1XT3A 2H64C 2QJBC 1TXAA 1IKCA 2L03A 1IDHA 1TGXA 2J8BA 2MJ0A 3ERAA 6EBXA 3EVSC 1KS6A 1NXBA 2N99A 1S4YA 1LXGA 1CRFA 1CTXA 1HAAA 2FD6U 2UWRA 3FEVA 1KTZB 2GOOB 4AEAA 2MJ4A 2OFSA 3KFDE 4ZQYA 3VTSA 1ZADA 2PJYC 1RL5A 4RUDA 2QJ9C 1G6MA 2H7ZB 2H62D 1L4WA 2CRSA 2QC1A 3BT1U 4EY8B 4FAOC 1LX5B 4XJJA 2H5FA 1NTXA 1KBTA 1MR6A 1QM7A 2LA1A 4OM5A 1CB9A 2BHIA 1KL8A 1KXIA 2LCRA 1I02A 1KBAA 1H0JA 1LXHA 1YWHA 1HC9B 1F94A 2H64B 2H8UA 4UY2C 1TXBA 1ERAA 1HOYA
chains in the Genus database with same CATH superfamily
1NORA 2NBTA 1HC9A 1CDTA 1BXPA 1KC4A 1FRAA 1ERGA 1ABTA 1TFSA 5DZ5A 1VB0A 2CCXA 2MHYA 1LJZA 2HLQA 1V6PA 2QJAC 1CVOA 3U74U 2MUOA 1FASA 1IDIA 3EBXA 1BTEA 4BIKB 2JVEA 1FFJA 4BDTB 5EBXA 4P7UA 2GOOC 1IK8A 3QB4B 4HQPF 1REWC 1ES7B 4LFTA 1RGJA 3NEQA 1CXNA 1CCQA 1CDQA 1PLOA 3HH7A 1IDLA 4DO8A 1FSCA 1F8UB 3NDSA 1JBDA 1CHVS 1CODA 1NTNA 1CXOA 1KBSA 1IDGA 1KFHA 1IJCA 1CDSA 1QKEA 1DRSA 4IYEA 2VLWA 2MFAA 5IMTD 1CDRA 1IQ9A 1CREA 3PLCA 2L5SA 2K3GA 4OM4A 3KFDI 2CTXA 2ERAA 2MUPA 3U73U 1JGKA 2PJYB 1NYSA 1ONJA 2I9BE 1LSIA 1FF4A 1M9ZA 3NH7A 1W6BA 1COEA 1JE9A 2CDXA 1FSSB 4FAOE 1QKDA 5DO6A 5IMYC 1NYUA 2CRTA 2X8BB 3BT2U 1NEAA 2JQPA 4QTIU 1MAHF 2H62C 2UX2A 1HAJA 1UG4A 2BTXA 1B41B 2HLRA 1KU6B 2ABXA 5DU1A 2MJYA 3LAQU 2H7ZA 1XT3A 2H64C 2QJBC 1TXAA 1IKCA 2L03A 1IDHA 1TGXA 2J8BA 2MJ0A 3ERAA 6EBXA 3EVSC 1KS6A 1NXBA 2N99A 1S4YA 1LXGA 1CRFA 1CTXA 1HAAA 2FD6U 2UWRA 3FEVA 1KTZB 2GOOB 4AEAA 2MJ4A 2OFSA 3KFDE 4ZQYA 3VTSA 1ZADA 2PJYC 1RL5A 4RUDA 2QJ9C 1G6MA 2H7ZB 2H62D 1L4WA 2CRSA 2QC1A 3BT1U 4EY8B 4FAOC 1LX5B 4KSNA 4XJJA 2H5FA 1NTXA 1KBTA 1MR6A 1QM7A 2LA1A 4OM5A 1CB9A 2BHIA 1KL8A 1KXIA 2LCRA 1I02A 1KBAA 1H0JA 1LXHA 1YWHA 1HC9B 1F94A 2H64B 2H8UA 4UY2C 1TXBA 1ERAA 1HOYA
chains in the Genus database with same CATH topology
1NORA 2NBTA 1HC9A 1CDTA 1BXPA 1KC4A 1FRAA 1ERGA 1ABTA 1TFSA 5DZ5A 1VB0A 2CCXA 2MHYA 1LJZA 2HLQA 1V6PA 2QJAC 1CVOA 3U74U 2MUOA 1FASA 1IDIA 3EBXA 1BTEA 4BIKB 2JVEA 1FFJA 4BDTB 5EBXA 4P7UA 2GOOC 1IK8A 3QB4B 4HQPF 1REWC 1ES7B 4LFTA 1RGJA 3NEQA 1CXNA 1CCQA 1CDQA 1PLOA 3HH7A 1IDLA 4DO8A 1FSCA 1F8UB 3NDSA 1JBDA 1CHVS 1CODA 1NTNA 1CXOA 1KBSA 1IDGA 1KFHA 1IJCA 1CDSA 1QKEA 1DRSA 4IYEA 2VLWA 2MFAA 5IMTD 1CDRA 1IQ9A 1CREA 3PLCA 2L5SA 2K3GA 4OM4A 3KFDI 2CTXA 2ERAA 2MUPA 3U73U 1JGKA 2PJYB 1NYSA 1ONJA 2I9BE 1LSIA 1FF4A 1M9ZA 3NH7A 1W6BA 1COEA 1JE9A 2CDXA 1FSSB 4FAOE 1QKDA 5DO6A 5IMYC 1NYUA 2CRTA 2X8BB 3BT2U 1NEAA 2JQPA 4QTIU 1MAHF 2H62C 2UX2A 1HAJA 1UG4A 2BTXA 1B41B 2HLRA 1KU6B 2ABXA 5DU1A 2MJYA 3LAQU 2H7ZA 1XT3A 2H64C 2QJBC 1TXAA 1IKCA 2L03A 1IDHA 1TGXA 2J8BA 2MJ0A 3ERAA 6EBXA 3EVSC 1KS6A 1NXBA 2N99A 1S4YA 1LXGA 1CRFA 1CTXA 1HAAA 2FD6U 2UWRA 3FEVA 1KTZB 2GOOB 4AEAA 2MJ4A 2OFSA 3KFDE 4ZQYA 3VTSA 1ZADA 2PJYC 1RL5A 4RUDA 2QJ9C 1G6MA 2H7ZB 2H62D 1L4WA 2CRSA 2QC1A 3BT1U 4EY8B 4FAOC 1LX5B 4KSNA 4XJJA 2H5FA 1NTXA 1KBTA 1MR6A 1QM7A 2LA1A 4OM5A 1CB9A 2BHIA 1KL8A 1KXIA 2LCRA 1I02A 1KBAA 1H0JA 1LXHA 1YWHA 1HC9B 1F94A 2H64B 2H8UA 4UY2C 1TXBA 1ERAA 1HOYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NOR A;  2NBT A;  1HC9 A;  1CDT A;  1BXP A;  1KC4 A;  1FRA A;  1ERG A;  1ABT A;  1TFS A;  5DZ5 A;  1VB0 A;  2CCX A;  2MHY A;  1LJZ A;  2HLQ A;  1V6P A;  2QJA C;  1CVO A;  3U74 U;  2MUO A;  1FAS A;  1IDI A;  3EBX A;  1BTE A;  4BIK B;  2JVE A;  1FFJ A;  4BDT B;  5EBX A;  4P7U A;  2GOO C;  1IK8 A;  3QB4 B;  4HQP F;  1REW C;  1ES7 B;  4LFT A;  1RGJ A;  3NEQ A;  1CXN A;  1CCQ A;  1CDQ A;  1PLO A;  3HH7 A;  1IDL A;  4DO8 A;  1FSC A;  1F8U B;  3NDS A;  1JBD A;  1CHV S;  1COD A;  1NTN A;  1CXO A;  1KBS A;  1IDG A;  1KFH A;  1IJC A;  1CDS A;  1QKE A;  1DRS A;  4IYE A;  2VLW A;  2MFA A;  5IMT D;  1CDR A;  1IQ9 A;  1CRE A;  3PLC A;  2L5S A;  2K3G A;  4OM4 A;  3KFD I;  2CTX A;  2ERA A;  2MUP A;  3U73 U;  1JGK A;  2PJY B;  1NYS A;  1ONJ A;  2I9B E;  1LSI A;  1FF4 A;  1M9Z A;  3NH7 A;  1W6B A;  1COE A;  1JE9 A;  2CDX A;  1FSS B;  4FAO E;  1QKD A;  5DO6 A;  5IMY C;  1NYU A;  2CRT A;  2X8B B;  3BT2 U;  1NEA A;  2JQP A;  4QTI U;  1MAH F;  2H62 C;  2UX2 A;  1HAJ A;  1UG4 A;  2BTX A;  1B41 B;  2HLR A;  1KU6 B;  2ABX A;  5DU1 A;  2MJY A;  3LAQ U;  2H7Z A;  1XT3 A;  2H64 C;  2QJB C;  1TXA A;  1IKC A;  2L03 A;  1IDH A;  1TGX A;  2J8B A;  2MJ0 A;  3ERA A;  6EBX A;  3EVS C;  1KS6 A;  1NXB A;  2N99 A;  1S4Y A;  1LXG A;  1CRF A;  1CTX A;  1HAA A;  2FD6 U;  2UWR A;  3FEV A;  1KTZ B;  2GOO B;  4AEA A;  2MJ4 A;  2OFS A;  3KFD E;  4ZQY A;  3VTS A;  1ZAD A;  2PJY C;  1RL5 A;  4RUD A;  2QJ9 C;  1G6M A;  2H7Z B;  2H62 D;  1L4W A;  2CRS A;  2QC1 A;  3BT1 U;  4EY8 B;  4FAO C;  1LX5 B;  4XJJ A;  2H5F A;  1NTX A;  1KBT A;  1MR6 A;  1QM7 A;  2LA1 A;  4OM5 A;  1CB9 A;  2BHI A;  1KL8 A;  1KXI A;  2LCR A;  1I02 A;  1KBA A;  1H0J A;  1LXH A;  1YWH A;  1HC9 B;  1F94 A;  2H64 B;  2H8U A;  4UY2 C;  1TXB A;  1ERA A;  1HOY A; 
#chains in the Genus database with same CATH topology
 1NOR A;  2NBT A;  1HC9 A;  1CDT A;  1BXP A;  1KC4 A;  1FRA A;  1ERG A;  1ABT A;  1TFS A;  5DZ5 A;  1VB0 A;  2CCX A;  2MHY A;  1LJZ A;  2HLQ A;  1V6P A;  2QJA C;  1CVO A;  3U74 U;  2MUO A;  1FAS A;  1IDI A;  3EBX A;  1BTE A;  4BIK B;  2JVE A;  1FFJ A;  4BDT B;  5EBX A;  4P7U A;  2GOO C;  1IK8 A;  3QB4 B;  4HQP F;  1REW C;  1ES7 B;  4LFT A;  1RGJ A;  3NEQ A;  1CXN A;  1CCQ A;  1CDQ A;  1PLO A;  3HH7 A;  1IDL A;  4DO8 A;  1FSC A;  1F8U B;  3NDS A;  1JBD A;  1CHV S;  1COD A;  1NTN A;  1CXO A;  1KBS A;  1IDG A;  1KFH A;  1IJC A;  1CDS A;  1QKE A;  1DRS A;  4IYE A;  2VLW A;  2MFA A;  5IMT D;  1CDR A;  1IQ9 A;  1CRE A;  3PLC A;  2L5S A;  2K3G A;  4OM4 A;  3KFD I;  2CTX A;  2ERA A;  2MUP A;  3U73 U;  1JGK A;  2PJY B;  1NYS A;  1ONJ A;  2I9B E;  1LSI A;  1FF4 A;  1M9Z A;  3NH7 A;  1W6B A;  1COE A;  1JE9 A;  2CDX A;  1FSS B;  4FAO E;  1QKD A;  5DO6 A;  5IMY C;  1NYU A;  2CRT A;  2X8B B;  3BT2 U;  1NEA A;  2JQP A;  4QTI U;  1MAH F;  2H62 C;  2UX2 A;  1HAJ A;  1UG4 A;  2BTX A;  1B41 B;  2HLR A;  1KU6 B;  2ABX A;  5DU1 A;  2MJY A;  3LAQ U;  2H7Z A;  1XT3 A;  2H64 C;  2QJB C;  1TXA A;  1IKC A;  2L03 A;  1IDH A;  1TGX A;  2J8B A;  2MJ0 A;  3ERA A;  6EBX A;  3EVS C;  1KS6 A;  1NXB A;  2N99 A;  1S4Y A;  1LXG A;  1CRF A;  1CTX A;  1HAA A;  2FD6 U;  2UWR A;  3FEV A;  1KTZ B;  2GOO B;  4AEA A;  2MJ4 A;  2OFS A;  3KFD E;  4ZQY A;  3VTS A;  1ZAD A;  2PJY C;  1RL5 A;  4RUD A;  2QJ9 C;  1G6M A;  2H7Z B;  2H62 D;  1L4W A;  2CRS A;  2QC1 A;  3BT1 U;  4EY8 B;  4FAO C;  1LX5 B;  4KSN A;  4XJJ A;  2H5F A;  1NTX A;  1KBT A;  1MR6 A;  1QM7 A;  2LA1 A;  4OM5 A;  1CB9 A;  2BHI A;  1KL8 A;  1KXI A;  2LCR A;  1I02 A;  1KBA A;  1H0J A;  1LXH A;  1YWH A;  1HC9 B;  1F94 A;  2H64 B;  2H8U A;  4UY2 C;  1TXB A;  1ERA A;  1HOY A; 
#chains in the Genus database with same CATH homology
 1NOR A;  2NBT A;  1HC9 A;  1CDT A;  1BXP A;  1KC4 A;  1FRA A;  1ERG A;  1ABT A;  1TFS A;  5DZ5 A;  1VB0 A;  2CCX A;  2MHY A;  1LJZ A;  2HLQ A;  1V6P A;  2QJA C;  1CVO A;  3U74 U;  2MUO A;  1FAS A;  1IDI A;  3EBX A;  1BTE A;  4BIK B;  2JVE A;  1FFJ A;  4BDT B;  5EBX A;  4P7U A;  2GOO C;  1IK8 A;  3QB4 B;  4HQP F;  1REW C;  1ES7 B;  4LFT A;  1RGJ A;  3NEQ A;  1CXN A;  1CCQ A;  1CDQ A;  1PLO A;  3HH7 A;  1IDL A;  4DO8 A;  1FSC A;  1F8U B;  3NDS A;  1JBD A;  1CHV S;  1COD A;  1NTN A;  1CXO A;  1KBS A;  1IDG A;  1KFH A;  1IJC A;  1CDS A;  1QKE A;  1DRS A;  4IYE A;  2VLW A;  2MFA A;  5IMT D;  1CDR A;  1IQ9 A;  1CRE A;  3PLC A;  2L5S A;  2K3G A;  4OM4 A;  3KFD I;  2CTX A;  2ERA A;  2MUP A;  3U73 U;  1JGK A;  2PJY B;  1NYS A;  1ONJ A;  2I9B E;  1LSI A;  1FF4 A;  1M9Z A;  3NH7 A;  1W6B A;  1COE A;  1JE9 A;  2CDX A;  1FSS B;  4FAO E;  1QKD A;  5DO6 A;  5IMY C;  1NYU A;  2CRT A;  2X8B B;  3BT2 U;  1NEA A;  2JQP A;  4QTI U;  1MAH F;  2H62 C;  2UX2 A;  1HAJ A;  1UG4 A;  2BTX A;  1B41 B;  2HLR A;  1KU6 B;  2ABX A;  5DU1 A;  2MJY A;  3LAQ U;  2H7Z A;  1XT3 A;  2H64 C;  2QJB C;  1TXA A;  1IKC A;  2L03 A;  1IDH A;  1TGX A;  2J8B A;  2MJ0 A;  3ERA A;  6EBX A;  3EVS C;  1KS6 A;  1NXB A;  2N99 A;  1S4Y A;  1LXG A;  1CRF A;  1CTX A;  1HAA A;  2FD6 U;  2UWR A;  3FEV A;  1KTZ B;  2GOO B;  4AEA A;  2MJ4 A;  2OFS A;  3KFD E;  4ZQY A;  3VTS A;  1ZAD A;  2PJY C;  1RL5 A;  4RUD A;  2QJ9 C;  1G6M A;  2H7Z B;  2H62 D;  1L4W A;  2CRS A;  2QC1 A;  3BT1 U;  4EY8 B;  4FAO C;  1LX5 B;  4KSN A;  4XJJ A;  2H5F A;  1NTX A;  1KBT A;  1MR6 A;  1QM7 A;  2LA1 A;  4OM5 A;  1CB9 A;  2BHI A;  1KL8 A;  1KXI A;  2LCR A;  1I02 A;  1KBA A;  1H0J A;  1LXH A;  1YWH A;  1HC9 B;  1F94 A;  2H64 B;  2H8U A;  4UY2 C;  1TXB A;  1ERA A;  1HOY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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