1F8UB

Crystal structure of mutant e202q of human acetylcholinesterase complexed with green mamba venom peptide fasciculin-ii
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords ACETYLCHOLINESTERASE
publication title Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/toxin
total genus 12
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2000-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 1f8uB00
2QJBC 4LFTA 2BTXA 2PJYC 2QJ9C 1CODA 1CDRA 1PLOA 1KBTA 1RGJA 5DZ5A 2H5FA 1JBDA 4AEAA 1I02A 1ERAA 1TXBA 3KFDI 1L4WA 1KBAA 1CVOA 4FAOC 4P7UA 4XJJA 2MJYA 1IDGA 1MR6A 1H0JA 1CXNA 2NBTA 1CB9A 1TGXA 1TXAA 5IMYC 1UG4A 1CDSA 3NDSA 2X8BB 3LAQU 2VLWA 2H62D 1JGKA 1FASA 2QC1A 3KFDE 1NTNA 1CREA 1NORA 1JE9A 2CRTA 2MUOA 1F8UB 1W6BA 4DO8A 1BXPA 6EBXA 1F94A 2MUPA 2JVEA 4EY8B 2MHYA 3NH7A 1CHVS 2UX2A 1IJCA 1LJZA 1CDQA 2FD6U 1B41B 2H64C 4FAOE 1HOYA 1KFHA 2L5SA 1DRSA 2PJYB 3PLCA 2H8UA 4BIKB 1KS6A 1HC9A 2K3GA 1KL8A 3EVSC 1V6PA 2MJ0A 1ONJA 1G6MA 5EBXA 1KC4A 3QB4B 1FF4A 1HC9B 1NYSA 4OM4A 2MFAA 4IYEA 1CRFA 2ABXA 5DU1A 3VTSA 1IDHA 5DO6A 1XT3A 1FFJA 2H64B 3BT1U 3ERAA 1REWC 2CCXA 2MJ4A 1RL5A 2H7ZA 1IQ9A 1S4YA 1IKCA 1TFSA 1ERGA 2OFSA 3EBXA 2CDXA 2H7ZB 3U73U 1FSCA 1NYUA 2GOOC 2CTXA 1LX5B 1LXHA 4BDTB 2L03A 2LA1A 1QM7A 2BHIA 1M9ZA 1HAJA 1KU6B 1CCQA 1FRAA 1KXIA 1HAAA 1KTZB 1BTEA 1IK8A 1YWHA 4OM5A 4ZQYA 2GOOB 1CXOA 1ES7B 1FSSB 1NTXA 2H62C 3FEVA 2N99A 4QTIU 1CTXA 5IMTD 3HH7A 1NEAA 1IDLA 1MAHF 1VB0A 1LXGA 2HLRA 2JQPA 3BT2U 2LCRA 4HQPF 1IDIA 1LSIA 2ERAA 1KBSA 2I9BE 1NXBA 1QKEA 1QKDA 1CDTA 3U74U 2UWRA 2HLQA 2J8BA 2CRSA 1ZADA 1COEA 4UY2C 4RUDA 1ABTA 2QJAC 3NEQA
chains in the Genus database with same CATH superfamily
2QJBC 4LFTA 2BTXA 2PJYC 2QJ9C 1CODA 1CDRA 1PLOA 1KBTA 1RGJA 5DZ5A 2H5FA 1JBDA 4AEAA 1I02A 1ERAA 1TXBA 3KFDI 1L4WA 1KBAA 1CVOA 4FAOC 4P7UA 4XJJA 2MJYA 1IDGA 1MR6A 1H0JA 1CXNA 2NBTA 1CB9A 1TGXA 1TXAA 5IMYC 1UG4A 1CDSA 3NDSA 2X8BB 3LAQU 2VLWA 2H62D 1JGKA 1FASA 2QC1A 3KFDE 1NTNA 1CREA 1NORA 1JE9A 2CRTA 2MUOA 1F8UB 1W6BA 4DO8A 1BXPA 6EBXA 1F94A 2MUPA 2JVEA 4EY8B 2MHYA 3NH7A 1CHVS 2UX2A 1IJCA 1LJZA 1CDQA 2FD6U 1B41B 2H64C 4FAOE 1HOYA 1KFHA 2L5SA 1DRSA 2PJYB 3PLCA 2H8UA 4BIKB 1KS6A 1HC9A 2K3GA 1KL8A 3EVSC 1V6PA 2MJ0A 1ONJA 1G6MA 5EBXA 1KC4A 3QB4B 1FF4A 1HC9B 1NYSA 4OM4A 2MFAA 4IYEA 1CRFA 2ABXA 5DU1A 3VTSA 1IDHA 5DO6A 1XT3A 1FFJA 2H64B 3BT1U 3ERAA 1REWC 2CCXA 2MJ4A 1RL5A 4KSNA 2H7ZA 1IQ9A 1S4YA 1IKCA 1TFSA 1ERGA 2OFSA 3EBXA 2CDXA 2H7ZB 3U73U 1FSCA 1NYUA 2GOOC 2CTXA 1LX5B 1LXHA 4BDTB 2L03A 2LA1A 1QM7A 2BHIA 1M9ZA 1HAJA 1KU6B 1CCQA 1FRAA 1KXIA 1HAAA 1KTZB 1BTEA 1IK8A 1YWHA 4OM5A 4ZQYA 2GOOB 1CXOA 1ES7B 1FSSB 1NTXA 2H62C 3FEVA 2N99A 4QTIU 1CTXA 5IMTD 3HH7A 1NEAA 1IDLA 1MAHF 1VB0A 1LXGA 2HLRA 2JQPA 3BT2U 2LCRA 4HQPF 1IDIA 1LSIA 2ERAA 1KBSA 2I9BE 1NXBA 1QKEA 1QKDA 1CDTA 3U74U 2UWRA 2HLQA 2J8BA 2CRSA 1ZADA 1COEA 4UY2C 4RUDA 1ABTA 2QJAC 3NEQA
chains in the Genus database with same CATH topology
2QJBC 4LFTA 2BTXA 2PJYC 2QJ9C 1CODA 1CDRA 1PLOA 1KBTA 1RGJA 5DZ5A 2H5FA 1JBDA 4AEAA 1I02A 1ERAA 1TXBA 3KFDI 1L4WA 1KBAA 1CVOA 4FAOC 4P7UA 4XJJA 2MJYA 1IDGA 1MR6A 1H0JA 1CXNA 2NBTA 1CB9A 1TGXA 1TXAA 5IMYC 1UG4A 1CDSA 3NDSA 2X8BB 3LAQU 2VLWA 2H62D 1JGKA 1FASA 2QC1A 3KFDE 1NTNA 1CREA 1NORA 1JE9A 2CRTA 2MUOA 1F8UB 1W6BA 4DO8A 1BXPA 6EBXA 1F94A 2MUPA 2JVEA 4EY8B 2MHYA 3NH7A 1CHVS 2UX2A 1IJCA 1LJZA 1CDQA 2FD6U 1B41B 2H64C 4FAOE 1HOYA 1KFHA 2L5SA 1DRSA 2PJYB 3PLCA 2H8UA 4BIKB 1KS6A 1HC9A 2K3GA 1KL8A 3EVSC 1V6PA 2MJ0A 1ONJA 1G6MA 5EBXA 1KC4A 3QB4B 1FF4A 1HC9B 1NYSA 4OM4A 2MFAA 4IYEA 1CRFA 2ABXA 5DU1A 3VTSA 1IDHA 5DO6A 1XT3A 1FFJA 2H64B 3BT1U 3ERAA 1REWC 2CCXA 2MJ4A 1RL5A 4KSNA 2H7ZA 1IQ9A 1S4YA 1IKCA 1TFSA 1ERGA 2OFSA 3EBXA 2CDXA 2H7ZB 3U73U 1FSCA 1NYUA 2GOOC 2CTXA 1LX5B 1LXHA 4BDTB 2L03A 2LA1A 1QM7A 2BHIA 1M9ZA 1HAJA 1KU6B 1CCQA 1FRAA 1KXIA 1HAAA 1KTZB 1BTEA 1IK8A 1YWHA 4OM5A 4ZQYA 2GOOB 1CXOA 1ES7B 1FSSB 1NTXA 2H62C 3FEVA 2N99A 4QTIU 1CTXA 5IMTD 3HH7A 1NEAA 1IDLA 1MAHF 1VB0A 1LXGA 2HLRA 2JQPA 3BT2U 2LCRA 4HQPF 1IDIA 1LSIA 2ERAA 1KBSA 2I9BE 1NXBA 1QKEA 1QKDA 1CDTA 3U74U 2UWRA 2HLQA 2J8BA 2CRSA 1ZADA 1COEA 4UY2C 4RUDA 1ABTA 2QJAC 3NEQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QJB C;  4LFT A;  2BTX A;  2PJY C;  2QJ9 C;  1COD A;  1CDR A;  1PLO A;  1KBT A;  1RGJ A;  5DZ5 A;  2H5F A;  1JBD A;  4AEA A;  1I02 A;  1ERA A;  1TXB A;  3KFD I;  1L4W A;  1KBA A;  1CVO A;  4FAO C;  4P7U A;  4XJJ A;  2MJY A;  1IDG A;  1MR6 A;  1H0J A;  1CXN A;  2NBT A;  1CB9 A;  1TGX A;  1TXA A;  5IMY C;  1UG4 A;  1CDS A;  3NDS A;  2X8B B;  3LAQ U;  2VLW A;  2H62 D;  1JGK A;  1FAS A;  2QC1 A;  3KFD E;  1NTN A;  1CRE A;  1NOR A;  1JE9 A;  2CRT A;  2MUO A;  1F8U B;  1W6B A;  4DO8 A;  1BXP A;  6EBX A;  1F94 A;  2MUP A;  2JVE A;  4EY8 B;  2MHY A;  3NH7 A;  1CHV S;  2UX2 A;  1IJC A;  1LJZ A;  1CDQ A;  2FD6 U;  1B41 B;  2H64 C;  4FAO E;  1HOY A;  1KFH A;  2L5S A;  1DRS A;  2PJY B;  3PLC A;  2H8U A;  4BIK B;  1KS6 A;  1HC9 A;  2K3G A;  1KL8 A;  3EVS C;  1V6P A;  2MJ0 A;  1ONJ A;  1G6M A;  5EBX A;  1KC4 A;  3QB4 B;  1FF4 A;  1HC9 B;  1NYS A;  4OM4 A;  2MFA A;  4IYE A;  1CRF A;  2ABX A;  5DU1 A;  3VTS A;  1IDH A;  5DO6 A;  1XT3 A;  1FFJ A;  2H64 B;  3BT1 U;  3ERA A;  1REW C;  2CCX A;  2MJ4 A;  1RL5 A;  2H7Z A;  1IQ9 A;  1S4Y A;  1IKC A;  1TFS A;  1ERG A;  2OFS A;  3EBX A;  2CDX A;  2H7Z B;  3U73 U;  1FSC A;  1NYU A;  2GOO C;  2CTX A;  1LX5 B;  1LXH A;  4BDT B;  2L03 A;  2LA1 A;  1QM7 A;  2BHI A;  1M9Z A;  1HAJ A;  1KU6 B;  1CCQ A;  1FRA A;  1KXI A;  1HAA A;  1KTZ B;  1BTE A;  1IK8 A;  1YWH A;  4OM5 A;  4ZQY A;  2GOO B;  1CXO A;  1ES7 B;  1FSS B;  1NTX A;  2H62 C;  3FEV A;  2N99 A;  4QTI U;  1CTX A;  5IMT D;  3HH7 A;  1NEA A;  1IDL A;  1MAH F;  1VB0 A;  1LXG A;  2HLR A;  2JQP A;  3BT2 U;  2LCR A;  4HQP F;  1IDI A;  1LSI A;  2ERA A;  1KBS A;  2I9B E;  1NXB A;  1QKE A;  1QKD A;  1CDT A;  3U74 U;  2UWR A;  2HLQ A;  2J8B A;  2CRS A;  1ZAD A;  1COE A;  4UY2 C;  4RUD A;  1ABT A;  2QJA C;  3NEQ A; 
#chains in the Genus database with same CATH topology
 2QJB C;  4LFT A;  2BTX A;  2PJY C;  2QJ9 C;  1COD A;  1CDR A;  1PLO A;  1KBT A;  1RGJ A;  5DZ5 A;  2H5F A;  1JBD A;  4AEA A;  1I02 A;  1ERA A;  1TXB A;  3KFD I;  1L4W A;  1KBA A;  1CVO A;  4FAO C;  4P7U A;  4XJJ A;  2MJY A;  1IDG A;  1MR6 A;  1H0J A;  1CXN A;  2NBT A;  1CB9 A;  1TGX A;  1TXA A;  5IMY C;  1UG4 A;  1CDS A;  3NDS A;  2X8B B;  3LAQ U;  2VLW A;  2H62 D;  1JGK A;  1FAS A;  2QC1 A;  3KFD E;  1NTN A;  1CRE A;  1NOR A;  1JE9 A;  2CRT A;  2MUO A;  1F8U B;  1W6B A;  4DO8 A;  1BXP A;  6EBX A;  1F94 A;  2MUP A;  2JVE A;  4EY8 B;  2MHY A;  3NH7 A;  1CHV S;  2UX2 A;  1IJC A;  1LJZ A;  1CDQ A;  2FD6 U;  1B41 B;  2H64 C;  4FAO E;  1HOY A;  1KFH A;  2L5S A;  1DRS A;  2PJY B;  3PLC A;  2H8U A;  4BIK B;  1KS6 A;  1HC9 A;  2K3G A;  1KL8 A;  3EVS C;  1V6P A;  2MJ0 A;  1ONJ A;  1G6M A;  5EBX A;  1KC4 A;  3QB4 B;  1FF4 A;  1HC9 B;  1NYS A;  4OM4 A;  2MFA A;  4IYE A;  1CRF A;  2ABX A;  5DU1 A;  3VTS A;  1IDH A;  5DO6 A;  1XT3 A;  1FFJ A;  2H64 B;  3BT1 U;  3ERA A;  1REW C;  2CCX A;  2MJ4 A;  1RL5 A;  4KSN A;  2H7Z A;  1IQ9 A;  1S4Y A;  1IKC A;  1TFS A;  1ERG A;  2OFS A;  3EBX A;  2CDX A;  2H7Z B;  3U73 U;  1FSC A;  1NYU A;  2GOO C;  2CTX A;  1LX5 B;  1LXH A;  4BDT B;  2L03 A;  2LA1 A;  1QM7 A;  2BHI A;  1M9Z A;  1HAJ A;  1KU6 B;  1CCQ A;  1FRA A;  1KXI A;  1HAA A;  1KTZ B;  1BTE A;  1IK8 A;  1YWH A;  4OM5 A;  4ZQY A;  2GOO B;  1CXO A;  1ES7 B;  1FSS B;  1NTX A;  2H62 C;  3FEV A;  2N99 A;  4QTI U;  1CTX A;  5IMT D;  3HH7 A;  1NEA A;  1IDL A;  1MAH F;  1VB0 A;  1LXG A;  2HLR A;  2JQP A;  3BT2 U;  2LCR A;  4HQP F;  1IDI A;  1LSI A;  2ERA A;  1KBS A;  2I9B E;  1NXB A;  1QKE A;  1QKD A;  1CDT A;  3U74 U;  2UWR A;  2HLQ A;  2J8B A;  2CRS A;  1ZAD A;  1COE A;  4UY2 C;  4RUD A;  1ABT A;  2QJA C;  3NEQ A; 
#chains in the Genus database with same CATH homology
 2QJB C;  4LFT A;  2BTX A;  2PJY C;  2QJ9 C;  1COD A;  1CDR A;  1PLO A;  1KBT A;  1RGJ A;  5DZ5 A;  2H5F A;  1JBD A;  4AEA A;  1I02 A;  1ERA A;  1TXB A;  3KFD I;  1L4W A;  1KBA A;  1CVO A;  4FAO C;  4P7U A;  4XJJ A;  2MJY A;  1IDG A;  1MR6 A;  1H0J A;  1CXN A;  2NBT A;  1CB9 A;  1TGX A;  1TXA A;  5IMY C;  1UG4 A;  1CDS A;  3NDS A;  2X8B B;  3LAQ U;  2VLW A;  2H62 D;  1JGK A;  1FAS A;  2QC1 A;  3KFD E;  1NTN A;  1CRE A;  1NOR A;  1JE9 A;  2CRT A;  2MUO A;  1F8U B;  1W6B A;  4DO8 A;  1BXP A;  6EBX A;  1F94 A;  2MUP A;  2JVE A;  4EY8 B;  2MHY A;  3NH7 A;  1CHV S;  2UX2 A;  1IJC A;  1LJZ A;  1CDQ A;  2FD6 U;  1B41 B;  2H64 C;  4FAO E;  1HOY A;  1KFH A;  2L5S A;  1DRS A;  2PJY B;  3PLC A;  2H8U A;  4BIK B;  1KS6 A;  1HC9 A;  2K3G A;  1KL8 A;  3EVS C;  1V6P A;  2MJ0 A;  1ONJ A;  1G6M A;  5EBX A;  1KC4 A;  3QB4 B;  1FF4 A;  1HC9 B;  1NYS A;  4OM4 A;  2MFA A;  4IYE A;  1CRF A;  2ABX A;  5DU1 A;  3VTS A;  1IDH A;  5DO6 A;  1XT3 A;  1FFJ A;  2H64 B;  3BT1 U;  3ERA A;  1REW C;  2CCX A;  2MJ4 A;  1RL5 A;  4KSN A;  2H7Z A;  1IQ9 A;  1S4Y A;  1IKC A;  1TFS A;  1ERG A;  2OFS A;  3EBX A;  2CDX A;  2H7Z B;  3U73 U;  1FSC A;  1NYU A;  2GOO C;  2CTX A;  1LX5 B;  1LXH A;  4BDT B;  2L03 A;  2LA1 A;  1QM7 A;  2BHI A;  1M9Z A;  1HAJ A;  1KU6 B;  1CCQ A;  1FRA A;  1KXI A;  1HAA A;  1KTZ B;  1BTE A;  1IK8 A;  1YWH A;  4OM5 A;  4ZQY A;  2GOO B;  1CXO A;  1ES7 B;  1FSS B;  1NTX A;  2H62 C;  3FEV A;  2N99 A;  4QTI U;  1CTX A;  5IMT D;  3HH7 A;  1NEA A;  1IDL A;  1MAH F;  1VB0 A;  1LXG A;  2HLR A;  2JQP A;  3BT2 U;  2LCR A;  4HQP F;  1IDI A;  1LSI A;  2ERA A;  1KBS A;  2I9B E;  1NXB A;  1QKE A;  1QKD A;  1CDT A;  3U74 U;  2UWR A;  2HLQ A;  2J8B A;  2CRS A;  1ZAD A;  1COE A;  4UY2 C;  4RUD A;  1ABT A;  2QJA C;  3NEQ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...