2FD6U

Structure of human urokinase plasminogen activator in complex with urokinase receptor and an anti-upar antibody at 1.9 a
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
276
structure length
249
Chain Sequence
SLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQLGDAFSMNHIDVSCCTKSGCNHPD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of human urokinase plasminogen activator in complex with its receptor
pubmed doi rcsb
molecule tags Immune system, hydrolase
source organism Homo sapiens
molecule keywords Urokinase-type plasminogen activator
total genus 57
structure length 249
sequence length 276
ec nomenclature
pdb deposition date 2005-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
U PF00021 UPAR_LY6 u-PAR/Ly-6 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2fd6U01
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2fd6U03
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2fd6U02
5DZ5A 5EBXA 1KU6B 6EBXA 1B41B 1KBSA 1LXHA 1JGKA 1F94A 3BT2U 2H62D 1KBAA 3U74U 3LAQU 4LFTA 2BTXA 5DO6A 5IMYC 1KC4A 1ERGA 1HC9B 4HQPF 1CREA 1LJZA 2QC1A 1JBDA 4DO8A 1I02A 3EBXA 3QB4B 2OFSA 1CCQA 1KBTA 2X8BB 1FSSB 3FEVA 3ERAA 1CXNA 1CDTA 2ERAA 2J8BA 1CRFA 3BT1U 2H62C 3NDSA 2CTXA 3NEQA 5IMTD 1HC9A 2K3GA 1HOYA 2NBTA 1W6BA 1F8UB 2HLRA 1IJCA 2UWRA 3EVSC 1KS6A 1TFSA 1NORA 3PLCA 1FRAA 2FD6U 1S4YA 2L03A 1ERAA 2N99A 2CDXA 4QTIU 3U73U 1ZADA 1IQ9A 1ES7B 2ABXA 1V6PA 2MJ4A 1YWHA 1CXOA 2VLWA 2H7ZB 1ABTA 1NEAA 1XT3A 2H8UA 1TGXA 1IDLA 2MJ0A 2CCXA 2JQPA 1CDSA 1IDIA 2CRSA 1RGJA 1LSIA 1FFJA 4P7UA 1CODA 1KTZB 2MUPA 1HAAA 1PLOA 4FAOC 1QKEA 1TXBA 4XJJA 2H7ZA 1CDRA 1NTNA 1FF4A 2MUOA 1CB9A 1KFHA 2L5SA 1RL5A 2GOOB 1DRSA 1KXIA 2MFAA 4BDTB 1IDHA 1NTXA 1ONJA 1FSCA 1NYUA 1TXAA 1MR6A 4UY2C 1LXGA 1CDQA 3KFDI 1HAJA 2QJ9C 2MJYA 4OM5A 2QJBC 2PJYB 1LX5B 1IDGA 1REWC 3HH7A 1IKCA 4FAOE 1KL8A 2CRTA 1H0JA 4IYEA 4ZQYA 5DU1A 1CHVS 1G6MA 4OM4A 1NXBA 3VTSA 1FASA 2MHYA 2H5FA 1BTEA 1M9ZA 1VB0A 2GOOC 1IK8A 1MAHF 3KFDE 1NYSA 1BXPA 1JE9A 2I9BE 1QKDA 2LA1A 4BIKB 4RUDA 2QJAC 4AEAA 2HLQA 2JVEA 4EY8B 1QM7A 1CTXA 2LCRA 2UX2A 2BHIA 2H64C 2PJYC 3NH7A 1COEA 1CVOA 2H64B 1L4WA 1UG4A
chains in the Genus database with same CATH superfamily
5DZ5A 5EBXA 1KU6B 6EBXA 1B41B 1KBSA 1LXHA 1JGKA 1F94A 3BT2U 2H62D 1KBAA 3U74U 3LAQU 4LFTA 2BTXA 5DO6A 5IMYC 1KC4A 1ERGA 1HC9B 4HQPF 1CREA 1LJZA 2QC1A 1JBDA 4DO8A 1I02A 3EBXA 3QB4B 2OFSA 1CCQA 1KBTA 2X8BB 1FSSB 3FEVA 3ERAA 1CXNA 1CDTA 2ERAA 2J8BA 1CRFA 3BT1U 2H62C 3NDSA 2CTXA 3NEQA 5IMTD 1HC9A 2K3GA 1HOYA 2NBTA 1W6BA 1F8UB 2HLRA 1IJCA 2UWRA 3EVSC 1KS6A 1TFSA 1NORA 3PLCA 1FRAA 2FD6U 1S4YA 2L03A 1ERAA 2N99A 2CDXA 4QTIU 3U73U 1ZADA 1IQ9A 1ES7B 2ABXA 1V6PA 2MJ4A 1YWHA 1CXOA 2VLWA 2H7ZB 1ABTA 1NEAA 1XT3A 2H8UA 1TGXA 1IDLA 2MJ0A 2CCXA 2JQPA 1CDSA 1IDIA 2CRSA 1RGJA 1LSIA 1FFJA 4P7UA 1CODA 1KTZB 2MUPA 1HAAA 1PLOA 4FAOC 1QKEA 1TXBA 4XJJA 2H7ZA 1CDRA 1NTNA 1FF4A 2MUOA 1CB9A 1KFHA 2L5SA 1RL5A 2GOOB 1DRSA 1KXIA 2MFAA 4BDTB 1IDHA 1NTXA 1ONJA 1FSCA 1NYUA 1TXAA 1MR6A 4UY2C 1LXGA 1CDQA 3KFDI 1HAJA 2QJ9C 2MJYA 4OM5A 2QJBC 2PJYB 1LX5B 1IDGA 1REWC 3HH7A 1IKCA 4FAOE 1KL8A 2CRTA 1H0JA 4IYEA 4ZQYA 5DU1A 1CHVS 1G6MA 4OM4A 1NXBA 3VTSA 1FASA 2MHYA 2H5FA 1BTEA 1M9ZA 1VB0A 2GOOC 1IK8A 1MAHF 3KFDE 1NYSA 1BXPA 1JE9A 2I9BE 1QKDA 2LA1A 4BIKB 4RUDA 2QJAC 4KSNA 4AEAA 2HLQA 2JVEA 4EY8B 1QM7A 1CTXA 2LCRA 2UX2A 2BHIA 2H64C 2PJYC 3NH7A 1COEA 1CVOA 2H64B 1L4WA 1UG4A
chains in the Genus database with same CATH topology
5DZ5A 5EBXA 1KU6B 6EBXA 1B41B 1KBSA 1LXHA 1JGKA 1F94A 3BT2U 2H62D 1KBAA 3U74U 3LAQU 4LFTA 2BTXA 5DO6A 5IMYC 1KC4A 1ERGA 1HC9B 4HQPF 1CREA 1LJZA 2QC1A 1JBDA 4DO8A 1I02A 3EBXA 3QB4B 2OFSA 1CCQA 1KBTA 2X8BB 1FSSB 3FEVA 3ERAA 1CXNA 1CDTA 2ERAA 2J8BA 1CRFA 3BT1U 2H62C 3NDSA 2CTXA 3NEQA 5IMTD 1HC9A 2K3GA 1HOYA 2NBTA 1W6BA 1F8UB 2HLRA 1IJCA 2UWRA 3EVSC 1KS6A 1TFSA 1NORA 3PLCA 1FRAA 2FD6U 1S4YA 2L03A 1ERAA 2N99A 2CDXA 4QTIU 3U73U 1ZADA 1IQ9A 1ES7B 2ABXA 1V6PA 2MJ4A 1YWHA 1CXOA 2VLWA 2H7ZB 1ABTA 1NEAA 1XT3A 2H8UA 1TGXA 1IDLA 2MJ0A 2CCXA 2JQPA 1CDSA 1IDIA 2CRSA 1RGJA 1LSIA 1FFJA 4P7UA 1CODA 1KTZB 2MUPA 1HAAA 1PLOA 4FAOC 1QKEA 1TXBA 4XJJA 2H7ZA 1CDRA 1NTNA 1FF4A 2MUOA 1CB9A 1KFHA 2L5SA 1RL5A 2GOOB 1DRSA 1KXIA 2MFAA 4BDTB 1IDHA 1NTXA 1ONJA 1FSCA 1NYUA 1TXAA 1MR6A 4UY2C 1LXGA 1CDQA 3KFDI 1HAJA 2QJ9C 2MJYA 4OM5A 2QJBC 2PJYB 1LX5B 1IDGA 1REWC 3HH7A 1IKCA 4FAOE 1KL8A 2CRTA 1H0JA 4IYEA 4ZQYA 5DU1A 1CHVS 1G6MA 4OM4A 1NXBA 3VTSA 1FASA 2MHYA 2H5FA 1BTEA 1M9ZA 1VB0A 2GOOC 1IK8A 1MAHF 3KFDE 1NYSA 1BXPA 1JE9A 2I9BE 1QKDA 2LA1A 4BIKB 4RUDA 2QJAC 4KSNA 4AEAA 2HLQA 2JVEA 4EY8B 1QM7A 1CTXA 2LCRA 2UX2A 2BHIA 2H64C 2PJYC 3NH7A 1COEA 1CVOA 2H64B 1L4WA 1UG4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DZ5 A;  5EBX A;  1KU6 B;  6EBX A;  1B41 B;  1KBS A;  1LXH A;  1JGK A;  1F94 A;  3BT2 U;  2H62 D;  1KBA A;  3U74 U;  3LAQ U;  4LFT A;  2BTX A;  5DO6 A;  5IMY C;  1KC4 A;  1ERG A;  1HC9 B;  4HQP F;  1CRE A;  1LJZ A;  2QC1 A;  1JBD A;  4DO8 A;  1I02 A;  3EBX A;  3QB4 B;  2OFS A;  1CCQ A;  1KBT A;  2X8B B;  1FSS B;  3FEV A;  3ERA A;  1CXN A;  1CDT A;  2ERA A;  2J8B A;  1CRF A;  3BT1 U;  2H62 C;  3NDS A;  2CTX A;  3NEQ A;  5IMT D;  1HC9 A;  2K3G A;  1HOY A;  2NBT A;  1W6B A;  1F8U B;  2HLR A;  1IJC A;  2UWR A;  3EVS C;  1KS6 A;  1TFS A;  1NOR A;  3PLC A;  1FRA A;  2FD6 U;  1S4Y A;  2L03 A;  1ERA A;  2N99 A;  2CDX A;  4QTI U;  3U73 U;  1ZAD A;  1IQ9 A;  1ES7 B;  2ABX A;  1V6P A;  2MJ4 A;  1YWH A;  1CXO A;  2VLW A;  2H7Z B;  1ABT A;  1NEA A;  1XT3 A;  2H8U A;  1TGX A;  1IDL A;  2MJ0 A;  2CCX A;  2JQP A;  1CDS A;  1IDI A;  2CRS A;  1RGJ A;  1LSI A;  1FFJ A;  4P7U A;  1COD A;  1KTZ B;  2MUP A;  1HAA A;  1PLO A;  4FAO C;  1QKE A;  1TXB A;  4XJJ A;  2H7Z A;  1CDR A;  1NTN A;  1FF4 A;  2MUO A;  1CB9 A;  1KFH A;  2L5S A;  1RL5 A;  2GOO B;  1DRS A;  1KXI A;  2MFA A;  4BDT B;  1IDH A;  1NTX A;  1ONJ A;  1FSC A;  1NYU A;  1TXA A;  1MR6 A;  4UY2 C;  1LXG A;  1CDQ A;  3KFD I;  1HAJ A;  2QJ9 C;  2MJY A;  4OM5 A;  2QJB C;  2PJY B;  1LX5 B;  1IDG A;  1REW C;  3HH7 A;  1IKC A;  4FAO E;  1KL8 A;  2CRT A;  1H0J A;  4IYE A;  4ZQY A;  5DU1 A;  1CHV S;  1G6M A;  4OM4 A;  1NXB A;  3VTS A;  1FAS A;  2MHY A;  2H5F A;  1BTE A;  1M9Z A;  1VB0 A;  2GOO C;  1IK8 A;  1MAH F;  3KFD E;  1NYS A;  1BXP A;  1JE9 A;  2I9B E;  1QKD A;  2LA1 A;  4BIK B;  4RUD A;  2QJA C;  4AEA A;  2HLQ A;  2JVE A;  4EY8 B;  1QM7 A;  1CTX A;  2LCR A;  2UX2 A;  2BHI A;  2H64 C;  2PJY C;  3NH7 A;  1COE A;  1CVO A;  2H64 B;  1L4W A;  1UG4 A; 
#chains in the Genus database with same CATH topology
 5DZ5 A;  5EBX A;  1KU6 B;  6EBX A;  1B41 B;  1KBS A;  1LXH A;  1JGK A;  1F94 A;  3BT2 U;  2H62 D;  1KBA A;  3U74 U;  3LAQ U;  4LFT A;  2BTX A;  5DO6 A;  5IMY C;  1KC4 A;  1ERG A;  1HC9 B;  4HQP F;  1CRE A;  1LJZ A;  2QC1 A;  1JBD A;  4DO8 A;  1I02 A;  3EBX A;  3QB4 B;  2OFS A;  1CCQ A;  1KBT A;  2X8B B;  1FSS B;  3FEV A;  3ERA A;  1CXN A;  1CDT A;  2ERA A;  2J8B A;  1CRF A;  3BT1 U;  2H62 C;  3NDS A;  2CTX A;  3NEQ A;  5IMT D;  1HC9 A;  2K3G A;  1HOY A;  2NBT A;  1W6B A;  1F8U B;  2HLR A;  1IJC A;  2UWR A;  3EVS C;  1KS6 A;  1TFS A;  1NOR A;  3PLC A;  1FRA A;  2FD6 U;  1S4Y A;  2L03 A;  1ERA A;  2N99 A;  2CDX A;  4QTI U;  3U73 U;  1ZAD A;  1IQ9 A;  1ES7 B;  2ABX A;  1V6P A;  2MJ4 A;  1YWH A;  1CXO A;  2VLW A;  2H7Z B;  1ABT A;  1NEA A;  1XT3 A;  2H8U A;  1TGX A;  1IDL A;  2MJ0 A;  2CCX A;  2JQP A;  1CDS A;  1IDI A;  2CRS A;  1RGJ A;  1LSI A;  1FFJ A;  4P7U A;  1COD A;  1KTZ B;  2MUP A;  1HAA A;  1PLO A;  4FAO C;  1QKE A;  1TXB A;  4XJJ A;  2H7Z A;  1CDR A;  1NTN A;  1FF4 A;  2MUO A;  1CB9 A;  1KFH A;  2L5S A;  1RL5 A;  2GOO B;  1DRS A;  1KXI A;  2MFA A;  4BDT B;  1IDH A;  1NTX A;  1ONJ A;  1FSC A;  1NYU A;  1TXA A;  1MR6 A;  4UY2 C;  1LXG A;  1CDQ A;  3KFD I;  1HAJ A;  2QJ9 C;  2MJY A;  4OM5 A;  2QJB C;  2PJY B;  1LX5 B;  1IDG A;  1REW C;  3HH7 A;  1IKC A;  4FAO E;  1KL8 A;  2CRT A;  1H0J A;  4IYE A;  4ZQY A;  5DU1 A;  1CHV S;  1G6M A;  4OM4 A;  1NXB A;  3VTS A;  1FAS A;  2MHY A;  2H5F A;  1BTE A;  1M9Z A;  1VB0 A;  2GOO C;  1IK8 A;  1MAH F;  3KFD E;  1NYS A;  1BXP A;  1JE9 A;  2I9B E;  1QKD A;  2LA1 A;  4BIK B;  4RUD A;  2QJA C;  4KSN A;  4AEA A;  2HLQ A;  2JVE A;  4EY8 B;  1QM7 A;  1CTX A;  2LCR A;  2UX2 A;  2BHI A;  2H64 C;  2PJY C;  3NH7 A;  1COE A;  1CVO A;  2H64 B;  1L4W A;  1UG4 A; 
#chains in the Genus database with same CATH homology
 5DZ5 A;  5EBX A;  1KU6 B;  6EBX A;  1B41 B;  1KBS A;  1LXH A;  1JGK A;  1F94 A;  3BT2 U;  2H62 D;  1KBA A;  3U74 U;  3LAQ U;  4LFT A;  2BTX A;  5DO6 A;  5IMY C;  1KC4 A;  1ERG A;  1HC9 B;  4HQP F;  1CRE A;  1LJZ A;  2QC1 A;  1JBD A;  4DO8 A;  1I02 A;  3EBX A;  3QB4 B;  2OFS A;  1CCQ A;  1KBT A;  2X8B B;  1FSS B;  3FEV A;  3ERA A;  1CXN A;  1CDT A;  2ERA A;  2J8B A;  1CRF A;  3BT1 U;  2H62 C;  3NDS A;  2CTX A;  3NEQ A;  5IMT D;  1HC9 A;  2K3G A;  1HOY A;  2NBT A;  1W6B A;  1F8U B;  2HLR A;  1IJC A;  2UWR A;  3EVS C;  1KS6 A;  1TFS A;  1NOR A;  3PLC A;  1FRA A;  2FD6 U;  1S4Y A;  2L03 A;  1ERA A;  2N99 A;  2CDX A;  4QTI U;  3U73 U;  1ZAD A;  1IQ9 A;  1ES7 B;  2ABX A;  1V6P A;  2MJ4 A;  1YWH A;  1CXO A;  2VLW A;  2H7Z B;  1ABT A;  1NEA A;  1XT3 A;  2H8U A;  1TGX A;  1IDL A;  2MJ0 A;  2CCX A;  2JQP A;  1CDS A;  1IDI A;  2CRS A;  1RGJ A;  1LSI A;  1FFJ A;  4P7U A;  1COD A;  1KTZ B;  2MUP A;  1HAA A;  1PLO A;  4FAO C;  1QKE A;  1TXB A;  4XJJ A;  2H7Z A;  1CDR A;  1NTN A;  1FF4 A;  2MUO A;  1CB9 A;  1KFH A;  2L5S A;  1RL5 A;  2GOO B;  1DRS A;  1KXI A;  2MFA A;  4BDT B;  1IDH A;  1NTX A;  1ONJ A;  1FSC A;  1NYU A;  1TXA A;  1MR6 A;  4UY2 C;  1LXG A;  1CDQ A;  3KFD I;  1HAJ A;  2QJ9 C;  2MJY A;  4OM5 A;  2QJB C;  2PJY B;  1LX5 B;  1IDG A;  1REW C;  3HH7 A;  1IKC A;  4FAO E;  1KL8 A;  2CRT A;  1H0J A;  4IYE A;  4ZQY A;  5DU1 A;  1CHV S;  1G6M A;  4OM4 A;  1NXB A;  3VTS A;  1FAS A;  2MHY A;  2H5F A;  1BTE A;  1M9Z A;  1VB0 A;  2GOO C;  1IK8 A;  1MAH F;  3KFD E;  1NYS A;  1BXP A;  1JE9 A;  2I9B E;  1QKD A;  2LA1 A;  4BIK B;  4RUD A;  2QJA C;  4KSN A;  4AEA A;  2HLQ A;  2JVE A;  4EY8 B;  1QM7 A;  1CTX A;  2LCR A;  2UX2 A;  2BHI A;  2H64 C;  2PJY C;  3NH7 A;  1COE A;  1CVO A;  2H64 B;  1L4W A;  1UG4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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