4BDTB

Human acetylcholinesterase in complex with huprine w and fasciculin 2
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/inhibitor
molecule keywords ACETYLCHOLINESTERASE
publication title Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
pubmed doi rcsb
source organism Homo sapiens
total genus 11
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-10-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4bdtB00
2GOOC 1CVOA 4EY8B 3KFDI 1MAHF 5EBXA 3HH7A 2PJYC 5DZ5A 2QJBC 1CRFA 1CDQA 1RL5A 4AEAA 1CDSA 1KBSA 1CTXA 2HLRA 2LCRA 2H62C 1B41B 1S4YA 4P7UA 1JGKA 2HLQA 1I02A 2OFSA 2UWRA 2JQPA 1KS6A 1IKCA 2MUOA 2L03A 2FD6U 2CRSA 2MJ4A 1NYSA 4LFTA 2ERAA 4UY2C 1COEA 3ERAA 2JVEA 1HC9B 1IJCA 1KBTA 1F94A 4FAOE 6EBXA 1KL8A 2H8UA 1TXAA 4ZQYA 1MR6A 2MJ0A 4BIKB 1G6MA 1RGJA 1CXNA 1KU6B 2H7ZA 1QM7A 1ABTA 2MUPA 1XT3A 1CCQA 2MFAA 2MJYA 1LXGA 1CB9A 1JBDA 4DO8A 1KXIA 2CCXA 1F8UB 1FSSB 1VB0A 2BTXA 3KFDE 4XJJA 5DO6A 1JE9A 1IDLA 2MHYA 1PLOA 1LJZA 2N99A 3PLCA 3BT2U 1HAAA 2J8BA 1IQ9A 1LXHA 1NXBA 2BHIA 1UG4A 5IMTD 3NEQA 3NDSA 2H62D 3BT1U 1REWC 4OM5A 2H64B 2QJ9C 1YWHA 1CXOA 1HOYA 2I9BE 1NTNA 4HQPF 2ABXA 2L5SA 1KTZB 2H7ZB 2CDXA 3VTSA 1ZADA 1CDRA 1IDHA 3NH7A 1IK8A 4FAOC 1IDIA 1CREA 2K3GA 5IMYC 1IDGA 5DU1A 2LA1A 1FFJA 1FRAA 2H5FA 2UX2A 3LAQU 1BXPA 2QC1A 1QKEA 1L4WA 1ES7B 1V6PA 2H64C 4QTIU 1M9ZA 1ONJA 1QKDA 1FASA 2GOOB 1FSCA 3EBXA 2PJYB 3U73U 1DRSA 1NEAA 1KBAA 3FEVA 2CRTA 1HAJA 1KFHA 1BTEA 4IYEA 4OM4A 1KC4A 1NORA 1TGXA 4BDTB 3EVSC 1W6BA 1CODA 2X8BB 1HC9A 1TXBA 1NTXA 2CTXA 1NYUA 2NBTA 1LX5B 3U74U 1CHVS 1LSIA 2QJAC 4RUDA 1ERGA 1CDTA 3QB4B 1ERAA 2VLWA 1FF4A 1TFSA 1H0JA
chains in the Genus database with same CATH superfamily
2GOOC 1CVOA 4EY8B 3KFDI 1MAHF 5EBXA 3HH7A 2PJYC 5DZ5A 2QJBC 1CRFA 1CDQA 1RL5A 4AEAA 1CDSA 1KBSA 1CTXA 2HLRA 2LCRA 2H62C 1B41B 1S4YA 4P7UA 1JGKA 2HLQA 1I02A 2OFSA 2UWRA 2JQPA 1KS6A 1IKCA 2MUOA 2L03A 2FD6U 2CRSA 2MJ4A 1NYSA 4LFTA 2ERAA 4UY2C 1COEA 3ERAA 2JVEA 1HC9B 1IJCA 1KBTA 1F94A 4FAOE 6EBXA 1KL8A 2H8UA 1TXAA 4ZQYA 1MR6A 2MJ0A 4BIKB 1G6MA 1RGJA 1CXNA 1KU6B 2H7ZA 1QM7A 1ABTA 2MUPA 1XT3A 1CCQA 2MFAA 2MJYA 1LXGA 1CB9A 1JBDA 4DO8A 1KXIA 2CCXA 1F8UB 1FSSB 1VB0A 2BTXA 3KFDE 4XJJA 5DO6A 1JE9A 1IDLA 2MHYA 1PLOA 1LJZA 2N99A 3PLCA 3BT2U 1HAAA 2J8BA 1IQ9A 1LXHA 1NXBA 2BHIA 1UG4A 5IMTD 3NEQA 3NDSA 2H62D 3BT1U 1REWC 4OM5A 2H64B 2QJ9C 1YWHA 1CXOA 1HOYA 2I9BE 1NTNA 4HQPF 2ABXA 2L5SA 1KTZB 2H7ZB 2CDXA 3VTSA 1ZADA 1CDRA 1IDHA 3NH7A 1IK8A 4FAOC 1IDIA 1CREA 2K3GA 5IMYC 1IDGA 5DU1A 2LA1A 1FFJA 1FRAA 2H5FA 2UX2A 3LAQU 1BXPA 2QC1A 1QKEA 1L4WA 1ES7B 1V6PA 2H64C 4QTIU 1M9ZA 1ONJA 1QKDA 1FASA 2GOOB 4KSNA 1FSCA 3EBXA 2PJYB 3U73U 1DRSA 1NEAA 1KBAA 3FEVA 2CRTA 1HAJA 1KFHA 1BTEA 4IYEA 4OM4A 1KC4A 1NORA 1TGXA 4BDTB 3EVSC 1W6BA 1CODA 2X8BB 1HC9A 1TXBA 1NTXA 2CTXA 1NYUA 2NBTA 1LX5B 3U74U 1CHVS 1LSIA 2QJAC 4RUDA 1ERGA 1CDTA 3QB4B 1ERAA 2VLWA 1FF4A 1TFSA 1H0JA
chains in the Genus database with same CATH topology
2GOOC 1CVOA 4EY8B 3KFDI 1MAHF 5EBXA 3HH7A 2PJYC 5DZ5A 2QJBC 1CRFA 1CDQA 1RL5A 4AEAA 1CDSA 1KBSA 1CTXA 2HLRA 2LCRA 2H62C 1B41B 1S4YA 4P7UA 1JGKA 2HLQA 1I02A 2OFSA 2UWRA 2JQPA 1KS6A 1IKCA 2MUOA 2L03A 2FD6U 2CRSA 2MJ4A 1NYSA 4LFTA 2ERAA 4UY2C 1COEA 3ERAA 2JVEA 1HC9B 1IJCA 1KBTA 1F94A 4FAOE 6EBXA 1KL8A 2H8UA 1TXAA 4ZQYA 1MR6A 2MJ0A 4BIKB 1G6MA 1RGJA 1CXNA 1KU6B 2H7ZA 1QM7A 1ABTA 2MUPA 1XT3A 1CCQA 2MFAA 2MJYA 1LXGA 1CB9A 1JBDA 4DO8A 1KXIA 2CCXA 1F8UB 1FSSB 1VB0A 2BTXA 3KFDE 4XJJA 5DO6A 1JE9A 1IDLA 2MHYA 1PLOA 1LJZA 2N99A 3PLCA 3BT2U 1HAAA 2J8BA 1IQ9A 1LXHA 1NXBA 2BHIA 1UG4A 5IMTD 3NEQA 3NDSA 2H62D 3BT1U 1REWC 4OM5A 2H64B 2QJ9C 1YWHA 1CXOA 1HOYA 2I9BE 1NTNA 4HQPF 2ABXA 2L5SA 1KTZB 2H7ZB 2CDXA 3VTSA 1ZADA 1CDRA 1IDHA 3NH7A 1IK8A 4FAOC 1IDIA 1CREA 2K3GA 5IMYC 1IDGA 5DU1A 2LA1A 1FFJA 1FRAA 2H5FA 2UX2A 3LAQU 1BXPA 2QC1A 1QKEA 1L4WA 1ES7B 1V6PA 2H64C 4QTIU 1M9ZA 1ONJA 1QKDA 1FASA 2GOOB 4KSNA 1FSCA 3EBXA 2PJYB 3U73U 1DRSA 1NEAA 1KBAA 3FEVA 2CRTA 1HAJA 1KFHA 1BTEA 4IYEA 4OM4A 1KC4A 1NORA 1TGXA 4BDTB 3EVSC 1W6BA 1CODA 2X8BB 1HC9A 1TXBA 1NTXA 2CTXA 1NYUA 2NBTA 1LX5B 3U74U 1CHVS 1LSIA 2QJAC 4RUDA 1ERGA 1CDTA 3QB4B 1ERAA 2VLWA 1FF4A 1TFSA 1H0JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GOO C;  1CVO A;  4EY8 B;  3KFD I;  1MAH F;  5EBX A;  3HH7 A;  2PJY C;  5DZ5 A;  2QJB C;  1CRF A;  1CDQ A;  1RL5 A;  4AEA A;  1CDS A;  1KBS A;  1CTX A;  2HLR A;  2LCR A;  2H62 C;  1B41 B;  1S4Y A;  4P7U A;  1JGK A;  2HLQ A;  1I02 A;  2OFS A;  2UWR A;  2JQP A;  1KS6 A;  1IKC A;  2MUO A;  2L03 A;  2FD6 U;  2CRS A;  2MJ4 A;  1NYS A;  4LFT A;  2ERA A;  4UY2 C;  1COE A;  3ERA A;  2JVE A;  1HC9 B;  1IJC A;  1KBT A;  1F94 A;  4FAO E;  6EBX A;  1KL8 A;  2H8U A;  1TXA A;  4ZQY A;  1MR6 A;  2MJ0 A;  4BIK B;  1G6M A;  1RGJ A;  1CXN A;  1KU6 B;  2H7Z A;  1QM7 A;  1ABT A;  2MUP A;  1XT3 A;  1CCQ A;  2MFA A;  2MJY A;  1LXG A;  1CB9 A;  1JBD A;  4DO8 A;  1KXI A;  2CCX A;  1F8U B;  1FSS B;  1VB0 A;  2BTX A;  3KFD E;  4XJJ A;  5DO6 A;  1JE9 A;  1IDL A;  2MHY A;  1PLO A;  1LJZ A;  2N99 A;  3PLC A;  3BT2 U;  1HAA A;  2J8B A;  1IQ9 A;  1LXH A;  1NXB A;  2BHI A;  1UG4 A;  5IMT D;  3NEQ A;  3NDS A;  2H62 D;  3BT1 U;  1REW C;  4OM5 A;  2H64 B;  2QJ9 C;  1YWH A;  1CXO A;  1HOY A;  2I9B E;  1NTN A;  4HQP F;  2ABX A;  2L5S A;  1KTZ B;  2H7Z B;  2CDX A;  3VTS A;  1ZAD A;  1CDR A;  1IDH A;  3NH7 A;  1IK8 A;  4FAO C;  1IDI A;  1CRE A;  2K3G A;  5IMY C;  1IDG A;  5DU1 A;  2LA1 A;  1FFJ A;  1FRA A;  2H5F A;  2UX2 A;  3LAQ U;  1BXP A;  2QC1 A;  1QKE A;  1L4W A;  1ES7 B;  1V6P A;  2H64 C;  4QTI U;  1M9Z A;  1ONJ A;  1QKD A;  1FAS A;  2GOO B;  1FSC A;  3EBX A;  2PJY B;  3U73 U;  1DRS A;  1NEA A;  1KBA A;  3FEV A;  2CRT A;  1HAJ A;  1KFH A;  1BTE A;  4IYE A;  4OM4 A;  1KC4 A;  1NOR A;  1TGX A;  4BDT B;  3EVS C;  1W6B A;  1COD A;  2X8B B;  1HC9 A;  1TXB A;  1NTX A;  2CTX A;  1NYU A;  2NBT A;  1LX5 B;  3U74 U;  1CHV S;  1LSI A;  2QJA C;  4RUD A;  1ERG A;  1CDT A;  3QB4 B;  1ERA A;  2VLW A;  1FF4 A;  1TFS A;  1H0J A; 
#chains in the Genus database with same CATH topology
 2GOO C;  1CVO A;  4EY8 B;  3KFD I;  1MAH F;  5EBX A;  3HH7 A;  2PJY C;  5DZ5 A;  2QJB C;  1CRF A;  1CDQ A;  1RL5 A;  4AEA A;  1CDS A;  1KBS A;  1CTX A;  2HLR A;  2LCR A;  2H62 C;  1B41 B;  1S4Y A;  4P7U A;  1JGK A;  2HLQ A;  1I02 A;  2OFS A;  2UWR A;  2JQP A;  1KS6 A;  1IKC A;  2MUO A;  2L03 A;  2FD6 U;  2CRS A;  2MJ4 A;  1NYS A;  4LFT A;  2ERA A;  4UY2 C;  1COE A;  3ERA A;  2JVE A;  1HC9 B;  1IJC A;  1KBT A;  1F94 A;  4FAO E;  6EBX A;  1KL8 A;  2H8U A;  1TXA A;  4ZQY A;  1MR6 A;  2MJ0 A;  4BIK B;  1G6M A;  1RGJ A;  1CXN A;  1KU6 B;  2H7Z A;  1QM7 A;  1ABT A;  2MUP A;  1XT3 A;  1CCQ A;  2MFA A;  2MJY A;  1LXG A;  1CB9 A;  1JBD A;  4DO8 A;  1KXI A;  2CCX A;  1F8U B;  1FSS B;  1VB0 A;  2BTX A;  3KFD E;  4XJJ A;  5DO6 A;  1JE9 A;  1IDL A;  2MHY A;  1PLO A;  1LJZ A;  2N99 A;  3PLC A;  3BT2 U;  1HAA A;  2J8B A;  1IQ9 A;  1LXH A;  1NXB A;  2BHI A;  1UG4 A;  5IMT D;  3NEQ A;  3NDS A;  2H62 D;  3BT1 U;  1REW C;  4OM5 A;  2H64 B;  2QJ9 C;  1YWH A;  1CXO A;  1HOY A;  2I9B E;  1NTN A;  4HQP F;  2ABX A;  2L5S A;  1KTZ B;  2H7Z B;  2CDX A;  3VTS A;  1ZAD A;  1CDR A;  1IDH A;  3NH7 A;  1IK8 A;  4FAO C;  1IDI A;  1CRE A;  2K3G A;  5IMY C;  1IDG A;  5DU1 A;  2LA1 A;  1FFJ A;  1FRA A;  2H5F A;  2UX2 A;  3LAQ U;  1BXP A;  2QC1 A;  1QKE A;  1L4W A;  1ES7 B;  1V6P A;  2H64 C;  4QTI U;  1M9Z A;  1ONJ A;  1QKD A;  1FAS A;  2GOO B;  4KSN A;  1FSC A;  3EBX A;  2PJY B;  3U73 U;  1DRS A;  1NEA A;  1KBA A;  3FEV A;  2CRT A;  1HAJ A;  1KFH A;  1BTE A;  4IYE A;  4OM4 A;  1KC4 A;  1NOR A;  1TGX A;  4BDT B;  3EVS C;  1W6B A;  1COD A;  2X8B B;  1HC9 A;  1TXB A;  1NTX A;  2CTX A;  1NYU A;  2NBT A;  1LX5 B;  3U74 U;  1CHV S;  1LSI A;  2QJA C;  4RUD A;  1ERG A;  1CDT A;  3QB4 B;  1ERA A;  2VLW A;  1FF4 A;  1TFS A;  1H0J A; 
#chains in the Genus database with same CATH homology
 2GOO C;  1CVO A;  4EY8 B;  3KFD I;  1MAH F;  5EBX A;  3HH7 A;  2PJY C;  5DZ5 A;  2QJB C;  1CRF A;  1CDQ A;  1RL5 A;  4AEA A;  1CDS A;  1KBS A;  1CTX A;  2HLR A;  2LCR A;  2H62 C;  1B41 B;  1S4Y A;  4P7U A;  1JGK A;  2HLQ A;  1I02 A;  2OFS A;  2UWR A;  2JQP A;  1KS6 A;  1IKC A;  2MUO A;  2L03 A;  2FD6 U;  2CRS A;  2MJ4 A;  1NYS A;  4LFT A;  2ERA A;  4UY2 C;  1COE A;  3ERA A;  2JVE A;  1HC9 B;  1IJC A;  1KBT A;  1F94 A;  4FAO E;  6EBX A;  1KL8 A;  2H8U A;  1TXA A;  4ZQY A;  1MR6 A;  2MJ0 A;  4BIK B;  1G6M A;  1RGJ A;  1CXN A;  1KU6 B;  2H7Z A;  1QM7 A;  1ABT A;  2MUP A;  1XT3 A;  1CCQ A;  2MFA A;  2MJY A;  1LXG A;  1CB9 A;  1JBD A;  4DO8 A;  1KXI A;  2CCX A;  1F8U B;  1FSS B;  1VB0 A;  2BTX A;  3KFD E;  4XJJ A;  5DO6 A;  1JE9 A;  1IDL A;  2MHY A;  1PLO A;  1LJZ A;  2N99 A;  3PLC A;  3BT2 U;  1HAA A;  2J8B A;  1IQ9 A;  1LXH A;  1NXB A;  2BHI A;  1UG4 A;  5IMT D;  3NEQ A;  3NDS A;  2H62 D;  3BT1 U;  1REW C;  4OM5 A;  2H64 B;  2QJ9 C;  1YWH A;  1CXO A;  1HOY A;  2I9B E;  1NTN A;  4HQP F;  2ABX A;  2L5S A;  1KTZ B;  2H7Z B;  2CDX A;  3VTS A;  1ZAD A;  1CDR A;  1IDH A;  3NH7 A;  1IK8 A;  4FAO C;  1IDI A;  1CRE A;  2K3G A;  5IMY C;  1IDG A;  5DU1 A;  2LA1 A;  1FFJ A;  1FRA A;  2H5F A;  2UX2 A;  3LAQ U;  1BXP A;  2QC1 A;  1QKE A;  1L4W A;  1ES7 B;  1V6P A;  2H64 C;  4QTI U;  1M9Z A;  1ONJ A;  1QKD A;  1FAS A;  2GOO B;  4KSN A;  1FSC A;  3EBX A;  2PJY B;  3U73 U;  1DRS A;  1NEA A;  1KBA A;  3FEV A;  2CRT A;  1HAJ A;  1KFH A;  1BTE A;  4IYE A;  4OM4 A;  1KC4 A;  1NOR A;  1TGX A;  4BDT B;  3EVS C;  1W6B A;  1COD A;  2X8B B;  1HC9 A;  1TXB A;  1NTX A;  2CTX A;  1NYU A;  2NBT A;  1LX5 B;  3U74 U;  1CHV S;  1LSI A;  2QJA C;  4RUD A;  1ERG A;  1CDT A;  3QB4 B;  1ERA A;  2VLW A;  1FF4 A;  1TFS A;  1H0J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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