4BDTB

Human acetylcholinesterase in complex with huprine w and fasciculin 2
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ACETYLCHOLINESTERASE
publication title Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/inhibitor
total genus 11
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-10-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4bdtB00
1XT3A 1KU6B 1JGKA 4DO8A 1TGXA 2HLRA 3NEQA 2MJ4A 1CCQA 1TXBA 1REWC 1M9ZA 1HC9B 5IMTD 1IDGA 2LA1A 1W6BA 3KFDI 3NDSA 1NYUA 4IYEA 4OM4A 1IDHA 2QJBC 1ES7B 2H7ZA 4EY8B 1JBDA 2H7ZB 1LSIA 2UWRA 1IJCA 4QTIU 1JE9A 4ZQYA 1COEA 1CDSA 1ERGA 2I9BE 2H64C 2ERAA 1NEAA 1NXBA 1B41B 1IQ9A 3NH7A 5DO6A 4BDTB 2N99A 1KC4A 1MAHF 4UY2C 1KL8A 2CTXA 1ZADA 3ERAA 3VTSA 2QC1A 4AEAA 2H8UA 2MJYA 4XJJA 1CHVS 1RGJA 1TXAA 1CXOA 1ONJA 2LCRA 1KTZB 2HLQA 3EVSC 1CODA 5EBXA 4RUDA 1VB0A 1FFJA 1F8UB 1KXIA 1QKDA 1CB9A 2L03A 1DRSA 1IDLA 2GOOB 2CRTA 2JQPA 1CXNA 1QM7A 4BIKB 1FSCA 1IK8A 2H62C 1HAAA 4FAOE 2MUOA 2BTXA 3QB4B 1PLOA 2K3GA 2PJYB 1LXGA 2BHIA 2QJ9C 1QKEA 1F94A 1UG4A 1YWHA 5IMYC 1I02A 1MR6A 1CDQA 1V6PA 1NTNA 1S4YA 2OFSA 3FEVA 2MUPA 1HOYA 2UX2A 2MHYA 1ERAA 4FAOC 4OM5A 1FASA 1CREA 3HH7A 1BXPA 1TFSA 2FD6U 1LX5B 1CVOA 2X8BB 3U73U 2GOOC 1HAJA 3BT2U 1L4WA 2MJ0A 5DZ5A 2VLWA 2NBTA 3U74U 2H62D 3KFDE 1RL5A 1FF4A 2CCXA 4P7UA 1NORA 2ABXA 2CDXA 1CRFA 1BTEA 1CTXA 3PLCA 1HC9A 1NYSA 6EBXA 1H0JA 1IDIA 2PJYC 3LAQU 2MFAA 1ABTA 2QJAC 1FSSB 1KS6A 1LJZA 5DU1A 1IKCA 4HQPF 2JVEA 2L5SA 1KBTA 2H64B 1CDTA 2H5FA 1FRAA 1KBAA 1KBSA 4LFTA 2J8BA 1CDRA 1KFHA 3EBXA 1G6MA 1NTXA 1LXHA 3BT1U 2CRSA
chains in the Genus database with same CATH superfamily
1XT3A 1KU6B 1JGKA 4DO8A 1TGXA 2HLRA 3NEQA 2MJ4A 1CCQA 1TXBA 1REWC 1M9ZA 1HC9B 5IMTD 1IDGA 2LA1A 1W6BA 3KFDI 3NDSA 1NYUA 4IYEA 4OM4A 1IDHA 2QJBC 1ES7B 2H7ZA 4EY8B 1JBDA 2H7ZB 1LSIA 2UWRA 1IJCA 4QTIU 1JE9A 4ZQYA 1COEA 1CDSA 1ERGA 2I9BE 2H64C 2ERAA 1NEAA 1NXBA 1B41B 1IQ9A 3NH7A 5DO6A 4BDTB 2N99A 1KC4A 1MAHF 4UY2C 1KL8A 2CTXA 1ZADA 3ERAA 3VTSA 2QC1A 4AEAA 2H8UA 2MJYA 4XJJA 1CHVS 1RGJA 1TXAA 1CXOA 1ONJA 2LCRA 1KTZB 2HLQA 3EVSC 1CODA 5EBXA 4RUDA 1VB0A 1FFJA 1F8UB 1KXIA 1QKDA 1CB9A 2L03A 1DRSA 1IDLA 2GOOB 2CRTA 2JQPA 1CXNA 1QM7A 4BIKB 1FSCA 1IK8A 2H62C 1HAAA 4FAOE 2MUOA 2BTXA 3QB4B 1PLOA 2K3GA 2PJYB 1LXGA 2BHIA 2QJ9C 1QKEA 1F94A 1UG4A 1YWHA 5IMYC 1I02A 1MR6A 1CDQA 1V6PA 1NTNA 1S4YA 2OFSA 3FEVA 2MUPA 1HOYA 2UX2A 2MHYA 1ERAA 4FAOC 4OM5A 1FASA 1CREA 3HH7A 1BXPA 1TFSA 2FD6U 1LX5B 1CVOA 2X8BB 3U73U 2GOOC 1HAJA 3BT2U 1L4WA 2MJ0A 5DZ5A 2VLWA 2NBTA 3U74U 2H62D 3KFDE 1RL5A 1FF4A 2CCXA 4P7UA 1NORA 2ABXA 2CDXA 1CRFA 1BTEA 1CTXA 3PLCA 1HC9A 1NYSA 6EBXA 1H0JA 1IDIA 4KSNA 2PJYC 3LAQU 2MFAA 1ABTA 2QJAC 1FSSB 1KS6A 1LJZA 5DU1A 1IKCA 4HQPF 2JVEA 2L5SA 1KBTA 2H64B 1CDTA 2H5FA 1FRAA 1KBAA 1KBSA 4LFTA 2J8BA 1CDRA 1KFHA 3EBXA 1G6MA 1NTXA 1LXHA 3BT1U 2CRSA
chains in the Genus database with same CATH topology
1XT3A 1KU6B 1JGKA 4DO8A 1TGXA 2HLRA 3NEQA 2MJ4A 1CCQA 1TXBA 1REWC 1M9ZA 1HC9B 5IMTD 1IDGA 2LA1A 1W6BA 3KFDI 3NDSA 1NYUA 4IYEA 4OM4A 1IDHA 2QJBC 1ES7B 2H7ZA 4EY8B 1JBDA 2H7ZB 1LSIA 2UWRA 1IJCA 4QTIU 1JE9A 4ZQYA 1COEA 1CDSA 1ERGA 2I9BE 2H64C 2ERAA 1NEAA 1NXBA 1B41B 1IQ9A 3NH7A 5DO6A 4BDTB 2N99A 1KC4A 1MAHF 4UY2C 1KL8A 2CTXA 1ZADA 3ERAA 3VTSA 2QC1A 4AEAA 2H8UA 2MJYA 4XJJA 1CHVS 1RGJA 1TXAA 1CXOA 1ONJA 2LCRA 1KTZB 2HLQA 3EVSC 1CODA 5EBXA 4RUDA 1VB0A 1FFJA 1F8UB 1KXIA 1QKDA 1CB9A 2L03A 1DRSA 1IDLA 2GOOB 2CRTA 2JQPA 1CXNA 1QM7A 4BIKB 1FSCA 1IK8A 2H62C 1HAAA 4FAOE 2MUOA 2BTXA 3QB4B 1PLOA 2K3GA 2PJYB 1LXGA 2BHIA 2QJ9C 1QKEA 1F94A 1UG4A 1YWHA 5IMYC 1I02A 1MR6A 1CDQA 1V6PA 1NTNA 1S4YA 2OFSA 3FEVA 2MUPA 1HOYA 2UX2A 2MHYA 1ERAA 4FAOC 4OM5A 1FASA 1CREA 3HH7A 1BXPA 1TFSA 2FD6U 1LX5B 1CVOA 2X8BB 3U73U 2GOOC 1HAJA 3BT2U 1L4WA 2MJ0A 5DZ5A 2VLWA 2NBTA 3U74U 2H62D 3KFDE 1RL5A 1FF4A 2CCXA 4P7UA 1NORA 2ABXA 2CDXA 1CRFA 1BTEA 1CTXA 3PLCA 1HC9A 1NYSA 6EBXA 1H0JA 1IDIA 4KSNA 2PJYC 3LAQU 2MFAA 1ABTA 2QJAC 1FSSB 1KS6A 1LJZA 5DU1A 1IKCA 4HQPF 2JVEA 2L5SA 1KBTA 2H64B 1CDTA 2H5FA 1FRAA 1KBAA 1KBSA 4LFTA 2J8BA 1CDRA 1KFHA 3EBXA 1G6MA 1NTXA 1LXHA 3BT1U 2CRSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XT3 A;  1KU6 B;  1JGK A;  4DO8 A;  1TGX A;  2HLR A;  3NEQ A;  2MJ4 A;  1CCQ A;  1TXB A;  1REW C;  1M9Z A;  1HC9 B;  5IMT D;  1IDG A;  2LA1 A;  1W6B A;  3KFD I;  3NDS A;  1NYU A;  4IYE A;  4OM4 A;  1IDH A;  2QJB C;  1ES7 B;  2H7Z A;  4EY8 B;  1JBD A;  2H7Z B;  1LSI A;  2UWR A;  1IJC A;  4QTI U;  1JE9 A;  4ZQY A;  1COE A;  1CDS A;  1ERG A;  2I9B E;  2H64 C;  2ERA A;  1NEA A;  1NXB A;  1B41 B;  1IQ9 A;  3NH7 A;  5DO6 A;  4BDT B;  2N99 A;  1KC4 A;  1MAH F;  4UY2 C;  1KL8 A;  2CTX A;  1ZAD A;  3ERA A;  3VTS A;  2QC1 A;  4AEA A;  2H8U A;  2MJY A;  4XJJ A;  1CHV S;  1RGJ A;  1TXA A;  1CXO A;  1ONJ A;  2LCR A;  1KTZ B;  2HLQ A;  3EVS C;  1COD A;  5EBX A;  4RUD A;  1VB0 A;  1FFJ A;  1F8U B;  1KXI A;  1QKD A;  1CB9 A;  2L03 A;  1DRS A;  1IDL A;  2GOO B;  2CRT A;  2JQP A;  1CXN A;  1QM7 A;  4BIK B;  1FSC A;  1IK8 A;  2H62 C;  1HAA A;  4FAO E;  2MUO A;  2BTX A;  3QB4 B;  1PLO A;  2K3G A;  2PJY B;  1LXG A;  2BHI A;  2QJ9 C;  1QKE A;  1F94 A;  1UG4 A;  1YWH A;  5IMY C;  1I02 A;  1MR6 A;  1CDQ A;  1V6P A;  1NTN A;  1S4Y A;  2OFS A;  3FEV A;  2MUP A;  1HOY A;  2UX2 A;  2MHY A;  1ERA A;  4FAO C;  4OM5 A;  1FAS A;  1CRE A;  3HH7 A;  1BXP A;  1TFS A;  2FD6 U;  1LX5 B;  1CVO A;  2X8B B;  3U73 U;  2GOO C;  1HAJ A;  3BT2 U;  1L4W A;  2MJ0 A;  5DZ5 A;  2VLW A;  2NBT A;  3U74 U;  2H62 D;  3KFD E;  1RL5 A;  1FF4 A;  2CCX A;  4P7U A;  1NOR A;  2ABX A;  2CDX A;  1CRF A;  1BTE A;  1CTX A;  3PLC A;  1HC9 A;  1NYS A;  6EBX A;  1H0J A;  1IDI A;  2PJY C;  3LAQ U;  2MFA A;  1ABT A;  2QJA C;  1FSS B;  1KS6 A;  1LJZ A;  5DU1 A;  1IKC A;  4HQP F;  2JVE A;  2L5S A;  1KBT A;  2H64 B;  1CDT A;  2H5F A;  1FRA A;  1KBA A;  1KBS A;  4LFT A;  2J8B A;  1CDR A;  1KFH A;  3EBX A;  1G6M A;  1NTX A;  1LXH A;  3BT1 U;  2CRS A; 
#chains in the Genus database with same CATH topology
 1XT3 A;  1KU6 B;  1JGK A;  4DO8 A;  1TGX A;  2HLR A;  3NEQ A;  2MJ4 A;  1CCQ A;  1TXB A;  1REW C;  1M9Z A;  1HC9 B;  5IMT D;  1IDG A;  2LA1 A;  1W6B A;  3KFD I;  3NDS A;  1NYU A;  4IYE A;  4OM4 A;  1IDH A;  2QJB C;  1ES7 B;  2H7Z A;  4EY8 B;  1JBD A;  2H7Z B;  1LSI A;  2UWR A;  1IJC A;  4QTI U;  1JE9 A;  4ZQY A;  1COE A;  1CDS A;  1ERG A;  2I9B E;  2H64 C;  2ERA A;  1NEA A;  1NXB A;  1B41 B;  1IQ9 A;  3NH7 A;  5DO6 A;  4BDT B;  2N99 A;  1KC4 A;  1MAH F;  4UY2 C;  1KL8 A;  2CTX A;  1ZAD A;  3ERA A;  3VTS A;  2QC1 A;  4AEA A;  2H8U A;  2MJY A;  4XJJ A;  1CHV S;  1RGJ A;  1TXA A;  1CXO A;  1ONJ A;  2LCR A;  1KTZ B;  2HLQ A;  3EVS C;  1COD A;  5EBX A;  4RUD A;  1VB0 A;  1FFJ A;  1F8U B;  1KXI A;  1QKD A;  1CB9 A;  2L03 A;  1DRS A;  1IDL A;  2GOO B;  2CRT A;  2JQP A;  1CXN A;  1QM7 A;  4BIK B;  1FSC A;  1IK8 A;  2H62 C;  1HAA A;  4FAO E;  2MUO A;  2BTX A;  3QB4 B;  1PLO A;  2K3G A;  2PJY B;  1LXG A;  2BHI A;  2QJ9 C;  1QKE A;  1F94 A;  1UG4 A;  1YWH A;  5IMY C;  1I02 A;  1MR6 A;  1CDQ A;  1V6P A;  1NTN A;  1S4Y A;  2OFS A;  3FEV A;  2MUP A;  1HOY A;  2UX2 A;  2MHY A;  1ERA A;  4FAO C;  4OM5 A;  1FAS A;  1CRE A;  3HH7 A;  1BXP A;  1TFS A;  2FD6 U;  1LX5 B;  1CVO A;  2X8B B;  3U73 U;  2GOO C;  1HAJ A;  3BT2 U;  1L4W A;  2MJ0 A;  5DZ5 A;  2VLW A;  2NBT A;  3U74 U;  2H62 D;  3KFD E;  1RL5 A;  1FF4 A;  2CCX A;  4P7U A;  1NOR A;  2ABX A;  2CDX A;  1CRF A;  1BTE A;  1CTX A;  3PLC A;  1HC9 A;  1NYS A;  6EBX A;  1H0J A;  1IDI A;  4KSN A;  2PJY C;  3LAQ U;  2MFA A;  1ABT A;  2QJA C;  1FSS B;  1KS6 A;  1LJZ A;  5DU1 A;  1IKC A;  4HQP F;  2JVE A;  2L5S A;  1KBT A;  2H64 B;  1CDT A;  2H5F A;  1FRA A;  1KBA A;  1KBS A;  4LFT A;  2J8B A;  1CDR A;  1KFH A;  3EBX A;  1G6M A;  1NTX A;  1LXH A;  3BT1 U;  2CRS A; 
#chains in the Genus database with same CATH homology
 1XT3 A;  1KU6 B;  1JGK A;  4DO8 A;  1TGX A;  2HLR A;  3NEQ A;  2MJ4 A;  1CCQ A;  1TXB A;  1REW C;  1M9Z A;  1HC9 B;  5IMT D;  1IDG A;  2LA1 A;  1W6B A;  3KFD I;  3NDS A;  1NYU A;  4IYE A;  4OM4 A;  1IDH A;  2QJB C;  1ES7 B;  2H7Z A;  4EY8 B;  1JBD A;  2H7Z B;  1LSI A;  2UWR A;  1IJC A;  4QTI U;  1JE9 A;  4ZQY A;  1COE A;  1CDS A;  1ERG A;  2I9B E;  2H64 C;  2ERA A;  1NEA A;  1NXB A;  1B41 B;  1IQ9 A;  3NH7 A;  5DO6 A;  4BDT B;  2N99 A;  1KC4 A;  1MAH F;  4UY2 C;  1KL8 A;  2CTX A;  1ZAD A;  3ERA A;  3VTS A;  2QC1 A;  4AEA A;  2H8U A;  2MJY A;  4XJJ A;  1CHV S;  1RGJ A;  1TXA A;  1CXO A;  1ONJ A;  2LCR A;  1KTZ B;  2HLQ A;  3EVS C;  1COD A;  5EBX A;  4RUD A;  1VB0 A;  1FFJ A;  1F8U B;  1KXI A;  1QKD A;  1CB9 A;  2L03 A;  1DRS A;  1IDL A;  2GOO B;  2CRT A;  2JQP A;  1CXN A;  1QM7 A;  4BIK B;  1FSC A;  1IK8 A;  2H62 C;  1HAA A;  4FAO E;  2MUO A;  2BTX A;  3QB4 B;  1PLO A;  2K3G A;  2PJY B;  1LXG A;  2BHI A;  2QJ9 C;  1QKE A;  1F94 A;  1UG4 A;  1YWH A;  5IMY C;  1I02 A;  1MR6 A;  1CDQ A;  1V6P A;  1NTN A;  1S4Y A;  2OFS A;  3FEV A;  2MUP A;  1HOY A;  2UX2 A;  2MHY A;  1ERA A;  4FAO C;  4OM5 A;  1FAS A;  1CRE A;  3HH7 A;  1BXP A;  1TFS A;  2FD6 U;  1LX5 B;  1CVO A;  2X8B B;  3U73 U;  2GOO C;  1HAJ A;  3BT2 U;  1L4W A;  2MJ0 A;  5DZ5 A;  2VLW A;  2NBT A;  3U74 U;  2H62 D;  3KFD E;  1RL5 A;  1FF4 A;  2CCX A;  4P7U A;  1NOR A;  2ABX A;  2CDX A;  1CRF A;  1BTE A;  1CTX A;  3PLC A;  1HC9 A;  1NYS A;  6EBX A;  1H0J A;  1IDI A;  4KSN A;  2PJY C;  3LAQ U;  2MFA A;  1ABT A;  2QJA C;  1FSS B;  1KS6 A;  1LJZ A;  5DU1 A;  1IKC A;  4HQP F;  2JVE A;  2L5S A;  1KBT A;  2H64 B;  1CDT A;  2H5F A;  1FRA A;  1KBA A;  1KBS A;  4LFT A;  2J8B A;  1CDR A;  1KFH A;  3EBX A;  1G6M A;  1NTX A;  1LXH A;  3BT1 U;  2CRS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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