4XJJA

Extracellular domain of type ii transforming growth factor beta receptor in complex with 2-(2-hydroxyethyl)ndsb-201
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
105
structure length
105
Chain Sequence
ALCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPTCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201
rcsb
molecule tags Cytokine receptor
source organism Homo sapiens
molecule keywords TGF-beta receptor type-2
total genus 24
structure length 105
sequence length 105
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2015-01-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4xjjA00
2FD6U 1CREA 1VB0A 3NH7A 1CCQA 2CDXA 1H0JA 4LFTA 1ONJA 1QM7A 6EBXA 2VLWA 1ABTA 4UY2C 1FF4A 1KFHA 1CDTA 1LXGA 2MJ0A 1HAJA 1HC9A 2QJAC 2BTXA 1ZADA 2QC1A 2X8BB 3KFDI 1IJCA 1IQ9A 2L03A 2J8BA 1PLOA 1NTXA 1CVOA 2UX2A 4ZQYA 4P7UA 3U73U 3NDSA 1KBSA 1B41B 2MUOA 1CHVS 2H62C 1JGKA 1IDLA 2H8UA 3VTSA 1IDHA 1G6MA 2MHYA 1JE9A 1COEA 1DRSA 1QKEA 2MJYA 1LXHA 1BTEA 1KC4A 2OFSA 1LX5B 1CDQA 4EY8B 5IMYC 2MFAA 4DO8A 2GOOB 2H62D 2MUPA 1KBAA 3EVSC 1IK8A 1IDIA 1CTXA 2CRSA 2I9BE 3ERAA 1CDSA 1REWC 2UWRA 1XT3A 1IDGA 2CRTA 2L5SA 1CXOA 1I02A 1W6BA 4IYEA 1FSSB 2QJBC 3HH7A 5DZ5A 1FSCA 2BHIA 1L4WA 1NYSA 3QB4B 4FAOE 3FEVA 2JVEA 2LA1A 2CTXA 2ERAA 1TXAA 4OM4A 1HC9B 1UG4A 5EBXA 1NTNA 2N99A 1KU6B 1BXPA 1F94A 2LCRA 2QJ9C 3BT1U 1MAHF 1ERGA 1JBDA 1CDRA 1QKDA 1KXIA 1CXNA 2PJYC 1RL5A 2H7ZA 1RGJA 2H64C 2H5FA 2MJ4A 3BT2U 1CRFA 1HOYA 5DO6A 1FFJA 4BDTB 3KFDE 4OM5A 1HAAA 5DU1A 3LAQU 4HQPF 3EBXA 1KTZB 1CB9A 1V6PA 2HLQA 2CCXA 2NBTA 1KBTA 4RUDA 1NYUA 1M9ZA 4BIKB 4QTIU 1LJZA 2ABXA 2PJYB 1TFSA 3NEQA 1ERAA 1S4YA 2GOOC 3U74U 1F8UB 1MR6A 2H64B 3PLCA 4XJJA 4AEAA 4FAOC 5IMTD 1LSIA 1NXBA 1CODA 1TXBA 1ES7B 2K3GA 2JQPA 2HLRA 1NEAA 1TGXA 1IKCA 1FRAA 1KL8A 1NORA 1KS6A 2H7ZB 1YWHA 1FASA
chains in the Genus database with same CATH superfamily
2FD6U 1CREA 1VB0A 3NH7A 1CCQA 2CDXA 1H0JA 4LFTA 1ONJA 1QM7A 6EBXA 2VLWA 1ABTA 4UY2C 1FF4A 1KFHA 1CDTA 1LXGA 2MJ0A 1HAJA 1HC9A 2QJAC 2BTXA 1ZADA 2QC1A 2X8BB 3KFDI 1IJCA 1IQ9A 2L03A 2J8BA 1PLOA 1NTXA 1CVOA 2UX2A 4ZQYA 4P7UA 3U73U 3NDSA 1KBSA 1B41B 2MUOA 1CHVS 2H62C 1JGKA 1IDLA 2H8UA 3VTSA 1IDHA 1G6MA 2MHYA 1JE9A 1COEA 1DRSA 1QKEA 2MJYA 1LXHA 1BTEA 1KC4A 2OFSA 1LX5B 1CDQA 4EY8B 5IMYC 2MFAA 4DO8A 2GOOB 2H62D 2MUPA 1KBAA 3EVSC 1IK8A 1IDIA 1CTXA 2CRSA 2I9BE 3ERAA 1CDSA 1REWC 2UWRA 1XT3A 1IDGA 2CRTA 2L5SA 1CXOA 1I02A 1W6BA 4IYEA 1FSSB 2QJBC 3HH7A 5DZ5A 1FSCA 2BHIA 1L4WA 1NYSA 3QB4B 4FAOE 3FEVA 2JVEA 2LA1A 2CTXA 2ERAA 1TXAA 4OM4A 1HC9B 1UG4A 5EBXA 1NTNA 2N99A 1KU6B 1BXPA 1F94A 2LCRA 2QJ9C 3BT1U 1MAHF 1ERGA 1JBDA 1CDRA 1QKDA 1KXIA 1CXNA 2PJYC 1RL5A 2H7ZA 1RGJA 2H64C 2H5FA 2MJ4A 3BT2U 1CRFA 1HOYA 5DO6A 1FFJA 4BDTB 3KFDE 4OM5A 1HAAA 5DU1A 3LAQU 4HQPF 3EBXA 1KTZB 1CB9A 1V6PA 2HLQA 2CCXA 2NBTA 1KBTA 4RUDA 1NYUA 1M9ZA 4BIKB 4QTIU 1LJZA 2ABXA 2PJYB 1TFSA 3NEQA 1ERAA 1S4YA 2GOOC 3U74U 1F8UB 1MR6A 2H64B 3PLCA 4XJJA 4AEAA 4FAOC 5IMTD 4KSNA 1LSIA 1NXBA 1CODA 1TXBA 1ES7B 2K3GA 2JQPA 2HLRA 1NEAA 1TGXA 1IKCA 1FRAA 1KL8A 1NORA 1KS6A 2H7ZB 1YWHA 1FASA
chains in the Genus database with same CATH topology
2FD6U 1CREA 1VB0A 3NH7A 1CCQA 2CDXA 1H0JA 4LFTA 1ONJA 1QM7A 6EBXA 2VLWA 1ABTA 4UY2C 1FF4A 1KFHA 1CDTA 1LXGA 2MJ0A 1HAJA 1HC9A 2QJAC 2BTXA 1ZADA 2QC1A 2X8BB 3KFDI 1IJCA 1IQ9A 2L03A 2J8BA 1PLOA 1NTXA 1CVOA 2UX2A 4ZQYA 4P7UA 3U73U 3NDSA 1KBSA 1B41B 2MUOA 1CHVS 2H62C 1JGKA 1IDLA 2H8UA 3VTSA 1IDHA 1G6MA 2MHYA 1JE9A 1COEA 1DRSA 1QKEA 2MJYA 1LXHA 1BTEA 1KC4A 2OFSA 1LX5B 1CDQA 4EY8B 5IMYC 2MFAA 4DO8A 2GOOB 2H62D 2MUPA 1KBAA 3EVSC 1IK8A 1IDIA 1CTXA 2CRSA 2I9BE 3ERAA 1CDSA 1REWC 2UWRA 1XT3A 1IDGA 2CRTA 2L5SA 1CXOA 1I02A 1W6BA 4IYEA 1FSSB 2QJBC 3HH7A 5DZ5A 1FSCA 2BHIA 1L4WA 1NYSA 3QB4B 4FAOE 3FEVA 2JVEA 2LA1A 2CTXA 2ERAA 1TXAA 4OM4A 1HC9B 1UG4A 5EBXA 1NTNA 2N99A 1KU6B 1BXPA 1F94A 2LCRA 2QJ9C 3BT1U 1MAHF 1ERGA 1JBDA 1CDRA 1QKDA 1KXIA 1CXNA 2PJYC 1RL5A 2H7ZA 1RGJA 2H64C 2H5FA 2MJ4A 3BT2U 1CRFA 1HOYA 5DO6A 1FFJA 4BDTB 3KFDE 4OM5A 1HAAA 5DU1A 3LAQU 4HQPF 3EBXA 1KTZB 1CB9A 1V6PA 2HLQA 2CCXA 2NBTA 1KBTA 4RUDA 1NYUA 1M9ZA 4BIKB 4QTIU 1LJZA 2ABXA 2PJYB 1TFSA 3NEQA 1ERAA 1S4YA 2GOOC 3U74U 1F8UB 1MR6A 2H64B 3PLCA 4XJJA 4AEAA 4FAOC 5IMTD 4KSNA 1LSIA 1NXBA 1CODA 1TXBA 1ES7B 2K3GA 2JQPA 2HLRA 1NEAA 1TGXA 1IKCA 1FRAA 1KL8A 1NORA 1KS6A 2H7ZB 1YWHA 1FASA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FD6 U;  1CRE A;  1VB0 A;  3NH7 A;  1CCQ A;  2CDX A;  1H0J A;  4LFT A;  1ONJ A;  1QM7 A;  6EBX A;  2VLW A;  1ABT A;  4UY2 C;  1FF4 A;  1KFH A;  1CDT A;  1LXG A;  2MJ0 A;  1HAJ A;  1HC9 A;  2QJA C;  2BTX A;  1ZAD A;  2QC1 A;  2X8B B;  3KFD I;  1IJC A;  1IQ9 A;  2L03 A;  2J8B A;  1PLO A;  1NTX A;  1CVO A;  2UX2 A;  4ZQY A;  4P7U A;  3U73 U;  3NDS A;  1KBS A;  1B41 B;  2MUO A;  1CHV S;  2H62 C;  1JGK A;  1IDL A;  2H8U A;  3VTS A;  1IDH A;  1G6M A;  2MHY A;  1JE9 A;  1COE A;  1DRS A;  1QKE A;  2MJY A;  1LXH A;  1BTE A;  1KC4 A;  2OFS A;  1LX5 B;  1CDQ A;  4EY8 B;  5IMY C;  2MFA A;  4DO8 A;  2GOO B;  2H62 D;  2MUP A;  1KBA A;  3EVS C;  1IK8 A;  1IDI A;  1CTX A;  2CRS A;  2I9B E;  3ERA A;  1CDS A;  1REW C;  2UWR A;  1XT3 A;  1IDG A;  2CRT A;  2L5S A;  1CXO A;  1I02 A;  1W6B A;  4IYE A;  1FSS B;  2QJB C;  3HH7 A;  5DZ5 A;  1FSC A;  2BHI A;  1L4W A;  1NYS A;  3QB4 B;  4FAO E;  3FEV A;  2JVE A;  2LA1 A;  2CTX A;  2ERA A;  1TXA A;  4OM4 A;  1HC9 B;  1UG4 A;  5EBX A;  1NTN A;  2N99 A;  1KU6 B;  1BXP A;  1F94 A;  2LCR A;  2QJ9 C;  3BT1 U;  1MAH F;  1ERG A;  1JBD A;  1CDR A;  1QKD A;  1KXI A;  1CXN A;  2PJY C;  1RL5 A;  2H7Z A;  1RGJ A;  2H64 C;  2H5F A;  2MJ4 A;  3BT2 U;  1CRF A;  1HOY A;  5DO6 A;  1FFJ A;  4BDT B;  3KFD E;  4OM5 A;  1HAA A;  5DU1 A;  3LAQ U;  4HQP F;  3EBX A;  1KTZ B;  1CB9 A;  1V6P A;  2HLQ A;  2CCX A;  2NBT A;  1KBT A;  4RUD A;  1NYU A;  1M9Z A;  4BIK B;  4QTI U;  1LJZ A;  2ABX A;  2PJY B;  1TFS A;  3NEQ A;  1ERA A;  1S4Y A;  2GOO C;  3U74 U;  1F8U B;  1MR6 A;  2H64 B;  3PLC A;  4XJJ A;  4AEA A;  4FAO C;  5IMT D;  1LSI A;  1NXB A;  1COD A;  1TXB A;  1ES7 B;  2K3G A;  2JQP A;  2HLR A;  1NEA A;  1TGX A;  1IKC A;  1FRA A;  1KL8 A;  1NOR A;  1KS6 A;  2H7Z B;  1YWH A;  1FAS A; 
#chains in the Genus database with same CATH topology
 2FD6 U;  1CRE A;  1VB0 A;  3NH7 A;  1CCQ A;  2CDX A;  1H0J A;  4LFT A;  1ONJ A;  1QM7 A;  6EBX A;  2VLW A;  1ABT A;  4UY2 C;  1FF4 A;  1KFH A;  1CDT A;  1LXG A;  2MJ0 A;  1HAJ A;  1HC9 A;  2QJA C;  2BTX A;  1ZAD A;  2QC1 A;  2X8B B;  3KFD I;  1IJC A;  1IQ9 A;  2L03 A;  2J8B A;  1PLO A;  1NTX A;  1CVO A;  2UX2 A;  4ZQY A;  4P7U A;  3U73 U;  3NDS A;  1KBS A;  1B41 B;  2MUO A;  1CHV S;  2H62 C;  1JGK A;  1IDL A;  2H8U A;  3VTS A;  1IDH A;  1G6M A;  2MHY A;  1JE9 A;  1COE A;  1DRS A;  1QKE A;  2MJY A;  1LXH A;  1BTE A;  1KC4 A;  2OFS A;  1LX5 B;  1CDQ A;  4EY8 B;  5IMY C;  2MFA A;  4DO8 A;  2GOO B;  2H62 D;  2MUP A;  1KBA A;  3EVS C;  1IK8 A;  1IDI A;  1CTX A;  2CRS A;  2I9B E;  3ERA A;  1CDS A;  1REW C;  2UWR A;  1XT3 A;  1IDG A;  2CRT A;  2L5S A;  1CXO A;  1I02 A;  1W6B A;  4IYE A;  1FSS B;  2QJB C;  3HH7 A;  5DZ5 A;  1FSC A;  2BHI A;  1L4W A;  1NYS A;  3QB4 B;  4FAO E;  3FEV A;  2JVE A;  2LA1 A;  2CTX A;  2ERA A;  1TXA A;  4OM4 A;  1HC9 B;  1UG4 A;  5EBX A;  1NTN A;  2N99 A;  1KU6 B;  1BXP A;  1F94 A;  2LCR A;  2QJ9 C;  3BT1 U;  1MAH F;  1ERG A;  1JBD A;  1CDR A;  1QKD A;  1KXI A;  1CXN A;  2PJY C;  1RL5 A;  2H7Z A;  1RGJ A;  2H64 C;  2H5F A;  2MJ4 A;  3BT2 U;  1CRF A;  1HOY A;  5DO6 A;  1FFJ A;  4BDT B;  3KFD E;  4OM5 A;  1HAA A;  5DU1 A;  3LAQ U;  4HQP F;  3EBX A;  1KTZ B;  1CB9 A;  1V6P A;  2HLQ A;  2CCX A;  2NBT A;  1KBT A;  4RUD A;  1NYU A;  1M9Z A;  4BIK B;  4QTI U;  1LJZ A;  2ABX A;  2PJY B;  1TFS A;  3NEQ A;  1ERA A;  1S4Y A;  2GOO C;  3U74 U;  1F8U B;  1MR6 A;  2H64 B;  3PLC A;  4XJJ A;  4AEA A;  4FAO C;  5IMT D;  4KSN A;  1LSI A;  1NXB A;  1COD A;  1TXB A;  1ES7 B;  2K3G A;  2JQP A;  2HLR A;  1NEA A;  1TGX A;  1IKC A;  1FRA A;  1KL8 A;  1NOR A;  1KS6 A;  2H7Z B;  1YWH A;  1FAS A; 
#chains in the Genus database with same CATH homology
 2FD6 U;  1CRE A;  1VB0 A;  3NH7 A;  1CCQ A;  2CDX A;  1H0J A;  4LFT A;  1ONJ A;  1QM7 A;  6EBX A;  2VLW A;  1ABT A;  4UY2 C;  1FF4 A;  1KFH A;  1CDT A;  1LXG A;  2MJ0 A;  1HAJ A;  1HC9 A;  2QJA C;  2BTX A;  1ZAD A;  2QC1 A;  2X8B B;  3KFD I;  1IJC A;  1IQ9 A;  2L03 A;  2J8B A;  1PLO A;  1NTX A;  1CVO A;  2UX2 A;  4ZQY A;  4P7U A;  3U73 U;  3NDS A;  1KBS A;  1B41 B;  2MUO A;  1CHV S;  2H62 C;  1JGK A;  1IDL A;  2H8U A;  3VTS A;  1IDH A;  1G6M A;  2MHY A;  1JE9 A;  1COE A;  1DRS A;  1QKE A;  2MJY A;  1LXH A;  1BTE A;  1KC4 A;  2OFS A;  1LX5 B;  1CDQ A;  4EY8 B;  5IMY C;  2MFA A;  4DO8 A;  2GOO B;  2H62 D;  2MUP A;  1KBA A;  3EVS C;  1IK8 A;  1IDI A;  1CTX A;  2CRS A;  2I9B E;  3ERA A;  1CDS A;  1REW C;  2UWR A;  1XT3 A;  1IDG A;  2CRT A;  2L5S A;  1CXO A;  1I02 A;  1W6B A;  4IYE A;  1FSS B;  2QJB C;  3HH7 A;  5DZ5 A;  1FSC A;  2BHI A;  1L4W A;  1NYS A;  3QB4 B;  4FAO E;  3FEV A;  2JVE A;  2LA1 A;  2CTX A;  2ERA A;  1TXA A;  4OM4 A;  1HC9 B;  1UG4 A;  5EBX A;  1NTN A;  2N99 A;  1KU6 B;  1BXP A;  1F94 A;  2LCR A;  2QJ9 C;  3BT1 U;  1MAH F;  1ERG A;  1JBD A;  1CDR A;  1QKD A;  1KXI A;  1CXN A;  2PJY C;  1RL5 A;  2H7Z A;  1RGJ A;  2H64 C;  2H5F A;  2MJ4 A;  3BT2 U;  1CRF A;  1HOY A;  5DO6 A;  1FFJ A;  4BDT B;  3KFD E;  4OM5 A;  1HAA A;  5DU1 A;  3LAQ U;  4HQP F;  3EBX A;  1KTZ B;  1CB9 A;  1V6P A;  2HLQ A;  2CCX A;  2NBT A;  1KBT A;  4RUD A;  1NYU A;  1M9Z A;  4BIK B;  4QTI U;  1LJZ A;  2ABX A;  2PJY B;  1TFS A;  3NEQ A;  1ERA A;  1S4Y A;  2GOO C;  3U74 U;  1F8U B;  1MR6 A;  2H64 B;  3PLC A;  4XJJ A;  4AEA A;  4FAO C;  5IMT D;  4KSN A;  1LSI A;  1NXB A;  1COD A;  1TXB A;  1ES7 B;  2K3G A;  2JQP A;  2HLR A;  1NEA A;  1TGX A;  1IKC A;  1FRA A;  1KL8 A;  1NOR A;  1KS6 A;  2H7Z B;  1YWH A;  1FAS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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