2PJYB

Structural basis for cooperative assembly of the tgf-beta signaling complex
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
108
structure length
108
Chain Sequence
AGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
pubmed doi rcsb
molecule keywords Transforming growth factor beta-3
molecule tags Cytokine/cytokine receptor
source organism Homo sapiens
total genus 20
structure length 108
sequence length 108
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2007-04-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2pjyB00
4UY2C 2H7ZA 1TXBA 2H7ZB 3BT1U 1CDTA 1COEA 3KFDI 5EBXA 1V6PA 3NEQA 1IDGA 1BTEA 2CRSA 5IMTD 4XJJA 1UG4A 1FF4A 2BTXA 1NYSA 2QJBC 2MHYA 1IJCA 1HC9A 1QKDA 1MR6A 2X8BB 1HC9B 1S4YA 3FEVA 4IYEA 4FAOE 5DZ5A 1TXAA 1KFHA 3QB4B 1ERAA 2K3GA 1M9ZA 1MAHF 2HLQA 1CVOA 4BDTB 1ES7B 1VB0A 2MJ4A 1NEAA 1CRFA 1CDSA 1CB9A 1HAJA 4RUDA 1LJZA 1RGJA 1YWHA 1W6BA 2VLWA 3U74U 1NORA 1FSSB 2FD6U 2I9BE 5DO6A 1CODA 3KFDE 1TFSA 1HOYA 3VTSA 2H64B 1RL5A 2CRTA 2OFSA 4P7UA 4HQPF 2L03A 4ZQYA 4LFTA 1KU6B 1QKEA 1IK8A 2MJ0A 3LAQU 4QTIU 1CCQA 3ERAA 1IDLA 2LCRA 1H0JA 2H64C 2J8BA 3U73U 1CDQA 1KS6A 1JE9A 4FAOC 5IMYC 4BIKB 1CREA 1IDHA 2GOOB 1CTXA 3BT2U 1G6MA 2JQPA 1LXHA 5DU1A 1DRSA 1NYUA 1I02A 1ERGA 2H62D 2MUPA 1CXNA 1KBAA 3EVSC 1FRAA 2GOOC 1PLOA 3NDSA 2LA1A 2H62C 3PLCA 3EBXA 2JVEA 1CXOA 1TGXA 1NTXA 2MJYA 2HLRA 1F8UB 2N99A 1BXPA 1ABTA 3HH7A 4OM5A 3NH7A 1HAAA 2H8UA 2PJYB 1LSIA 1F94A 1LX5B 2MUOA 1KL8A 1ONJA 4AEAA 1L4WA 1KTZB 2L5SA 2NBTA 2QJ9C 1JGKA 2QC1A 6EBXA 1CDRA 2PJYC 4EY8B 1FFJA 2ABXA 2ERAA 2H5FA 2QJAC 2UX2A 1QM7A 1CHVS 1IDIA 2CTXA 1IKCA 1FSCA 1XT3A 1B41B 1NXBA 2UWRA 4DO8A 1REWC 1ZADA 4OM4A 2CDXA 1FASA 1JBDA 2BHIA 1KC4A 1KXIA 1KBSA 2CCXA 1KBTA 1IQ9A 1NTNA 2MFAA 1LXGA
chains in the Genus database with same CATH superfamily
4UY2C 2H7ZA 1TXBA 2H7ZB 3BT1U 1CDTA 1COEA 3KFDI 5EBXA 1V6PA 3NEQA 1IDGA 1BTEA 2CRSA 5IMTD 4XJJA 1UG4A 1FF4A 2BTXA 1NYSA 2QJBC 2MHYA 1IJCA 1HC9A 1QKDA 1MR6A 2X8BB 1HC9B 1S4YA 3FEVA 4IYEA 4FAOE 5DZ5A 1TXAA 1KFHA 3QB4B 1ERAA 2K3GA 1M9ZA 1MAHF 2HLQA 1CVOA 4BDTB 1ES7B 1VB0A 2MJ4A 1NEAA 1CRFA 1CDSA 1CB9A 1HAJA 4RUDA 1LJZA 1RGJA 1YWHA 1W6BA 2VLWA 3U74U 1NORA 1FSSB 2FD6U 2I9BE 5DO6A 1CODA 3KFDE 1TFSA 1HOYA 3VTSA 2H64B 1RL5A 2CRTA 2OFSA 4P7UA 4HQPF 2L03A 4ZQYA 4LFTA 1KU6B 1QKEA 1IK8A 2MJ0A 3LAQU 4QTIU 1CCQA 3ERAA 1IDLA 2LCRA 1H0JA 2H64C 2J8BA 3U73U 1CDQA 1KS6A 1JE9A 4FAOC 5IMYC 4BIKB 1CREA 1IDHA 2GOOB 1CTXA 3BT2U 1G6MA 2JQPA 1LXHA 5DU1A 1DRSA 1NYUA 1I02A 1ERGA 2H62D 2MUPA 1CXNA 1KBAA 3EVSC 1FRAA 2GOOC 1PLOA 3NDSA 2LA1A 2H62C 3PLCA 3EBXA 2JVEA 1CXOA 1TGXA 1NTXA 2MJYA 2HLRA 1F8UB 2N99A 1BXPA 1ABTA 3HH7A 4OM5A 3NH7A 1HAAA 2H8UA 2PJYB 1LSIA 1F94A 1LX5B 2MUOA 1KL8A 1ONJA 4AEAA 1L4WA 1KTZB 2L5SA 2NBTA 2QJ9C 1JGKA 2QC1A 6EBXA 1CDRA 2PJYC 4EY8B 1FFJA 2ABXA 2ERAA 2H5FA 2QJAC 2UX2A 1QM7A 1CHVS 1IDIA 2CTXA 1IKCA 1FSCA 1XT3A 1B41B 1NXBA 2UWRA 4DO8A 1REWC 1ZADA 4OM4A 2CDXA 1FASA 1JBDA 4KSNA 2BHIA 1KC4A 1KXIA 1KBSA 2CCXA 1KBTA 1IQ9A 1NTNA 2MFAA 1LXGA
chains in the Genus database with same CATH topology
4UY2C 2H7ZA 1TXBA 2H7ZB 3BT1U 1CDTA 1COEA 3KFDI 5EBXA 1V6PA 3NEQA 1IDGA 1BTEA 2CRSA 5IMTD 4XJJA 1UG4A 1FF4A 2BTXA 1NYSA 2QJBC 2MHYA 1IJCA 1HC9A 1QKDA 1MR6A 2X8BB 1HC9B 1S4YA 3FEVA 4IYEA 4FAOE 5DZ5A 1TXAA 1KFHA 3QB4B 1ERAA 2K3GA 1M9ZA 1MAHF 2HLQA 1CVOA 4BDTB 1ES7B 1VB0A 2MJ4A 1NEAA 1CRFA 1CDSA 1CB9A 1HAJA 4RUDA 1LJZA 1RGJA 1YWHA 1W6BA 2VLWA 3U74U 1NORA 1FSSB 2FD6U 2I9BE 5DO6A 1CODA 3KFDE 1TFSA 1HOYA 3VTSA 2H64B 1RL5A 2CRTA 2OFSA 4P7UA 4HQPF 2L03A 4ZQYA 4LFTA 1KU6B 1QKEA 1IK8A 2MJ0A 3LAQU 4QTIU 1CCQA 3ERAA 1IDLA 2LCRA 1H0JA 2H64C 2J8BA 3U73U 1CDQA 1KS6A 1JE9A 4FAOC 5IMYC 4BIKB 1CREA 1IDHA 2GOOB 1CTXA 3BT2U 1G6MA 2JQPA 1LXHA 5DU1A 1DRSA 1NYUA 1I02A 1ERGA 2H62D 2MUPA 1CXNA 1KBAA 3EVSC 1FRAA 2GOOC 1PLOA 3NDSA 2LA1A 2H62C 3PLCA 3EBXA 2JVEA 1CXOA 1TGXA 1NTXA 2MJYA 2HLRA 1F8UB 2N99A 1BXPA 1ABTA 3HH7A 4OM5A 3NH7A 1HAAA 2H8UA 2PJYB 1LSIA 1F94A 1LX5B 2MUOA 1KL8A 1ONJA 4AEAA 1L4WA 1KTZB 2L5SA 2NBTA 2QJ9C 1JGKA 2QC1A 6EBXA 1CDRA 2PJYC 4EY8B 1FFJA 2ABXA 2ERAA 2H5FA 2QJAC 2UX2A 1QM7A 1CHVS 1IDIA 2CTXA 1IKCA 1FSCA 1XT3A 1B41B 1NXBA 2UWRA 4DO8A 1REWC 1ZADA 4OM4A 2CDXA 1FASA 1JBDA 4KSNA 2BHIA 1KC4A 1KXIA 1KBSA 2CCXA 1KBTA 1IQ9A 1NTNA 2MFAA 1LXGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UY2 C;  2H7Z A;  1TXB A;  2H7Z B;  3BT1 U;  1CDT A;  1COE A;  3KFD I;  5EBX A;  1V6P A;  3NEQ A;  1IDG A;  1BTE A;  2CRS A;  5IMT D;  4XJJ A;  1UG4 A;  1FF4 A;  2BTX A;  1NYS A;  2QJB C;  2MHY A;  1IJC A;  1HC9 A;  1QKD A;  1MR6 A;  2X8B B;  1HC9 B;  1S4Y A;  3FEV A;  4IYE A;  4FAO E;  5DZ5 A;  1TXA A;  1KFH A;  3QB4 B;  1ERA A;  2K3G A;  1M9Z A;  1MAH F;  2HLQ A;  1CVO A;  4BDT B;  1ES7 B;  1VB0 A;  2MJ4 A;  1NEA A;  1CRF A;  1CDS A;  1CB9 A;  1HAJ A;  4RUD A;  1LJZ A;  1RGJ A;  1YWH A;  1W6B A;  2VLW A;  3U74 U;  1NOR A;  1FSS B;  2FD6 U;  2I9B E;  5DO6 A;  1COD A;  3KFD E;  1TFS A;  1HOY A;  3VTS A;  2H64 B;  1RL5 A;  2CRT A;  2OFS A;  4P7U A;  4HQP F;  2L03 A;  4ZQY A;  4LFT A;  1KU6 B;  1QKE A;  1IK8 A;  2MJ0 A;  3LAQ U;  4QTI U;  1CCQ A;  3ERA A;  1IDL A;  2LCR A;  1H0J A;  2H64 C;  2J8B A;  3U73 U;  1CDQ A;  1KS6 A;  1JE9 A;  4FAO C;  5IMY C;  4BIK B;  1CRE A;  1IDH A;  2GOO B;  1CTX A;  3BT2 U;  1G6M A;  2JQP A;  1LXH A;  5DU1 A;  1DRS A;  1NYU A;  1I02 A;  1ERG A;  2H62 D;  2MUP A;  1CXN A;  1KBA A;  3EVS C;  1FRA A;  2GOO C;  1PLO A;  3NDS A;  2LA1 A;  2H62 C;  3PLC A;  3EBX A;  2JVE A;  1CXO A;  1TGX A;  1NTX A;  2MJY A;  2HLR A;  1F8U B;  2N99 A;  1BXP A;  1ABT A;  3HH7 A;  4OM5 A;  3NH7 A;  1HAA A;  2H8U A;  2PJY B;  1LSI A;  1F94 A;  1LX5 B;  2MUO A;  1KL8 A;  1ONJ A;  4AEA A;  1L4W A;  1KTZ B;  2L5S A;  2NBT A;  2QJ9 C;  1JGK A;  2QC1 A;  6EBX A;  1CDR A;  2PJY C;  4EY8 B;  1FFJ A;  2ABX A;  2ERA A;  2H5F A;  2QJA C;  2UX2 A;  1QM7 A;  1CHV S;  1IDI A;  2CTX A;  1IKC A;  1FSC A;  1XT3 A;  1B41 B;  1NXB A;  2UWR A;  4DO8 A;  1REW C;  1ZAD A;  4OM4 A;  2CDX A;  1FAS A;  1JBD A;  2BHI A;  1KC4 A;  1KXI A;  1KBS A;  2CCX A;  1KBT A;  1IQ9 A;  1NTN A;  2MFA A;  1LXG A; 
#chains in the Genus database with same CATH topology
 4UY2 C;  2H7Z A;  1TXB A;  2H7Z B;  3BT1 U;  1CDT A;  1COE A;  3KFD I;  5EBX A;  1V6P A;  3NEQ A;  1IDG A;  1BTE A;  2CRS A;  5IMT D;  4XJJ A;  1UG4 A;  1FF4 A;  2BTX A;  1NYS A;  2QJB C;  2MHY A;  1IJC A;  1HC9 A;  1QKD A;  1MR6 A;  2X8B B;  1HC9 B;  1S4Y A;  3FEV A;  4IYE A;  4FAO E;  5DZ5 A;  1TXA A;  1KFH A;  3QB4 B;  1ERA A;  2K3G A;  1M9Z A;  1MAH F;  2HLQ A;  1CVO A;  4BDT B;  1ES7 B;  1VB0 A;  2MJ4 A;  1NEA A;  1CRF A;  1CDS A;  1CB9 A;  1HAJ A;  4RUD A;  1LJZ A;  1RGJ A;  1YWH A;  1W6B A;  2VLW A;  3U74 U;  1NOR A;  1FSS B;  2FD6 U;  2I9B E;  5DO6 A;  1COD A;  3KFD E;  1TFS A;  1HOY A;  3VTS A;  2H64 B;  1RL5 A;  2CRT A;  2OFS A;  4P7U A;  4HQP F;  2L03 A;  4ZQY A;  4LFT A;  1KU6 B;  1QKE A;  1IK8 A;  2MJ0 A;  3LAQ U;  4QTI U;  1CCQ A;  3ERA A;  1IDL A;  2LCR A;  1H0J A;  2H64 C;  2J8B A;  3U73 U;  1CDQ A;  1KS6 A;  1JE9 A;  4FAO C;  5IMY C;  4BIK B;  1CRE A;  1IDH A;  2GOO B;  1CTX A;  3BT2 U;  1G6M A;  2JQP A;  1LXH A;  5DU1 A;  1DRS A;  1NYU A;  1I02 A;  1ERG A;  2H62 D;  2MUP A;  1CXN A;  1KBA A;  3EVS C;  1FRA A;  2GOO C;  1PLO A;  3NDS A;  2LA1 A;  2H62 C;  3PLC A;  3EBX A;  2JVE A;  1CXO A;  1TGX A;  1NTX A;  2MJY A;  2HLR A;  1F8U B;  2N99 A;  1BXP A;  1ABT A;  3HH7 A;  4OM5 A;  3NH7 A;  1HAA A;  2H8U A;  2PJY B;  1LSI A;  1F94 A;  1LX5 B;  2MUO A;  1KL8 A;  1ONJ A;  4AEA A;  1L4W A;  1KTZ B;  2L5S A;  2NBT A;  2QJ9 C;  1JGK A;  2QC1 A;  6EBX A;  1CDR A;  2PJY C;  4EY8 B;  1FFJ A;  2ABX A;  2ERA A;  2H5F A;  2QJA C;  2UX2 A;  1QM7 A;  1CHV S;  1IDI A;  2CTX A;  1IKC A;  1FSC A;  1XT3 A;  1B41 B;  1NXB A;  2UWR A;  4DO8 A;  1REW C;  1ZAD A;  4OM4 A;  2CDX A;  1FAS A;  1JBD A;  4KSN A;  2BHI A;  1KC4 A;  1KXI A;  1KBS A;  2CCX A;  1KBT A;  1IQ9 A;  1NTN A;  2MFA A;  1LXG A; 
#chains in the Genus database with same CATH homology
 4UY2 C;  2H7Z A;  1TXB A;  2H7Z B;  3BT1 U;  1CDT A;  1COE A;  3KFD I;  5EBX A;  1V6P A;  3NEQ A;  1IDG A;  1BTE A;  2CRS A;  5IMT D;  4XJJ A;  1UG4 A;  1FF4 A;  2BTX A;  1NYS A;  2QJB C;  2MHY A;  1IJC A;  1HC9 A;  1QKD A;  1MR6 A;  2X8B B;  1HC9 B;  1S4Y A;  3FEV A;  4IYE A;  4FAO E;  5DZ5 A;  1TXA A;  1KFH A;  3QB4 B;  1ERA A;  2K3G A;  1M9Z A;  1MAH F;  2HLQ A;  1CVO A;  4BDT B;  1ES7 B;  1VB0 A;  2MJ4 A;  1NEA A;  1CRF A;  1CDS A;  1CB9 A;  1HAJ A;  4RUD A;  1LJZ A;  1RGJ A;  1YWH A;  1W6B A;  2VLW A;  3U74 U;  1NOR A;  1FSS B;  2FD6 U;  2I9B E;  5DO6 A;  1COD A;  3KFD E;  1TFS A;  1HOY A;  3VTS A;  2H64 B;  1RL5 A;  2CRT A;  2OFS A;  4P7U A;  4HQP F;  2L03 A;  4ZQY A;  4LFT A;  1KU6 B;  1QKE A;  1IK8 A;  2MJ0 A;  3LAQ U;  4QTI U;  1CCQ A;  3ERA A;  1IDL A;  2LCR A;  1H0J A;  2H64 C;  2J8B A;  3U73 U;  1CDQ A;  1KS6 A;  1JE9 A;  4FAO C;  5IMY C;  4BIK B;  1CRE A;  1IDH A;  2GOO B;  1CTX A;  3BT2 U;  1G6M A;  2JQP A;  1LXH A;  5DU1 A;  1DRS A;  1NYU A;  1I02 A;  1ERG A;  2H62 D;  2MUP A;  1CXN A;  1KBA A;  3EVS C;  1FRA A;  2GOO C;  1PLO A;  3NDS A;  2LA1 A;  2H62 C;  3PLC A;  3EBX A;  2JVE A;  1CXO A;  1TGX A;  1NTX A;  2MJY A;  2HLR A;  1F8U B;  2N99 A;  1BXP A;  1ABT A;  3HH7 A;  4OM5 A;  3NH7 A;  1HAA A;  2H8U A;  2PJY B;  1LSI A;  1F94 A;  1LX5 B;  2MUO A;  1KL8 A;  1ONJ A;  4AEA A;  1L4W A;  1KTZ B;  2L5S A;  2NBT A;  2QJ9 C;  1JGK A;  2QC1 A;  6EBX A;  1CDR A;  2PJY C;  4EY8 B;  1FFJ A;  2ABX A;  2ERA A;  2H5F A;  2QJA C;  2UX2 A;  1QM7 A;  1CHV S;  1IDI A;  2CTX A;  1IKC A;  1FSC A;  1XT3 A;  1B41 B;  1NXB A;  2UWR A;  4DO8 A;  1REW C;  1ZAD A;  4OM4 A;  2CDX A;  1FAS A;  1JBD A;  4KSN A;  2BHI A;  1KC4 A;  1KXI A;  1KBS A;  2CCX A;  1KBT A;  1IQ9 A;  1NTN A;  2MFA A;  1LXG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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