4EY8B

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Acetylcholinesterase
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-05-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4ey8B00
1REWC 1KL8A 1QKDA 1QM7A 3QB4B 1LXGA 1TXBA 4EY8B 1F94A 2MJYA 2I9BE 1LJZA 1NTNA 2GOOB 2K3GA 3U73U 1CDTA 4ZQYA 1TGXA 2HLRA 2LA1A 1W6BA 1LX5B 4BIKB 1KTZB 1QKEA 2UWRA 1JBDA 1KBTA 2HLQA 1YWHA 2CCXA 1CXNA 2UX2A 1CCQA 1LXHA 1CDSA 4BDTB 1S4YA 1FRAA 1KC4A 1KFHA 1NORA 3NDSA 2QJAC 2H64C 3HH7A 1NYSA 2H7ZA 4XJJA 1MAHF 1KU6B 1NEAA 2J8BA 2MUPA 4AEAA 2JVEA 1HAJA 2QJBC 4QTIU 1IK8A 1HC9B 1FFJA 2X8BB 4UY2C 1RGJA 1CVOA 1IDGA 3ERAA 1ERAA 1CB9A 1IJCA 1CTXA 1FSSB 6EBXA 3NEQA 1KXIA 5DU1A 1PLOA 2MHYA 5IMYC 2ERAA 5IMTD 2PJYB 1BTEA 2CDXA 4LFTA 2VLWA 3BT1U 1COEA 2NBTA 2L5SA 1H0JA 5DO6A 1TXAA 2MJ4A 1IDLA 2H8UA 1CHVS 3EVSC 1IKCA 4P7UA 1I02A 1CODA 1JE9A 2N99A 2GOOC 1IDHA 3LAQU 2LCRA 3U74U 3VTSA 1HOYA 1XT3A 1FSCA 3KFDE 1ES7B 2OFSA 4FAOC 1G6MA 2CRTA 1CREA 1MR6A 2BHIA 1DRSA 1CDQA 1ABTA 1M9ZA 2L03A 1V6PA 4HQPF 1NTXA 1VB0A 1CXOA 1IQ9A 1B41B 1LSIA 1RL5A 2JQPA 2MFAA 2H5FA 1TFSA 4RUDA 4FAOE 4OM4A 2QC1A 1L4WA 1HC9A 2H64B 1NYUA 1ERGA 1IDIA 2MJ0A 2H7ZB 2FD6U 3NH7A 1JGKA 2MUOA 1CRFA 1KS6A 4OM5A 1BXPA 1UG4A 1ZADA 3KFDI 1HAAA 3BT2U 3PLCA 4IYEA 2H62D 2BTXA 3EBXA 4DO8A 2QJ9C 1FF4A 1KBAA 2PJYC 1ONJA 2CTXA 2ABXA 3FEVA 1NXBA 1F8UB 1CDRA 1FASA 2H62C 1KBSA 5DZ5A 5EBXA 2CRSA
chains in the Genus database with same CATH superfamily
1REWC 1KL8A 1QKDA 1QM7A 3QB4B 1LXGA 1TXBA 4EY8B 1F94A 2MJYA 2I9BE 1LJZA 1NTNA 2GOOB 2K3GA 3U73U 1CDTA 4ZQYA 1TGXA 2HLRA 2LA1A 1W6BA 1LX5B 4BIKB 1KTZB 1QKEA 2UWRA 1JBDA 1KBTA 2HLQA 1YWHA 2CCXA 1CXNA 2UX2A 1CCQA 1LXHA 1CDSA 4BDTB 1S4YA 1FRAA 1KC4A 1KFHA 1NORA 3NDSA 2QJAC 2H64C 3HH7A 1NYSA 2H7ZA 4XJJA 1MAHF 1KU6B 1NEAA 2J8BA 2MUPA 4AEAA 2JVEA 1HAJA 2QJBC 4QTIU 1IK8A 1HC9B 1FFJA 2X8BB 4UY2C 1RGJA 1CVOA 1IDGA 3ERAA 1ERAA 1CB9A 1IJCA 1CTXA 1FSSB 6EBXA 3NEQA 1KXIA 5DU1A 1PLOA 2MHYA 5IMYC 2ERAA 5IMTD 2PJYB 1BTEA 2CDXA 4LFTA 2VLWA 3BT1U 1COEA 2NBTA 2L5SA 1H0JA 5DO6A 1TXAA 2MJ4A 1IDLA 2H8UA 1CHVS 3EVSC 1IKCA 4P7UA 1I02A 1CODA 1JE9A 2N99A 2GOOC 1IDHA 3LAQU 2LCRA 3U74U 3VTSA 1HOYA 1XT3A 1FSCA 3KFDE 1ES7B 2OFSA 4FAOC 1G6MA 2CRTA 1CREA 1MR6A 2BHIA 1DRSA 1CDQA 1ABTA 4KSNA 1M9ZA 2L03A 1V6PA 4HQPF 1NTXA 1VB0A 1CXOA 1IQ9A 1B41B 1LSIA 1RL5A 2JQPA 2MFAA 2H5FA 1TFSA 4RUDA 4FAOE 4OM4A 2QC1A 1L4WA 1HC9A 2H64B 1NYUA 1ERGA 1IDIA 2MJ0A 2H7ZB 2FD6U 3NH7A 1JGKA 2MUOA 1CRFA 1KS6A 4OM5A 1BXPA 1UG4A 1ZADA 3KFDI 1HAAA 3BT2U 3PLCA 4IYEA 2H62D 2BTXA 3EBXA 4DO8A 2QJ9C 1FF4A 1KBAA 2PJYC 1ONJA 2CTXA 2ABXA 3FEVA 1NXBA 1F8UB 1CDRA 1FASA 2H62C 1KBSA 5DZ5A 5EBXA 2CRSA
chains in the Genus database with same CATH topology
1REWC 1KL8A 1QKDA 1QM7A 3QB4B 1LXGA 1TXBA 4EY8B 1F94A 2MJYA 2I9BE 1LJZA 1NTNA 2GOOB 2K3GA 3U73U 1CDTA 4ZQYA 1TGXA 2HLRA 2LA1A 1W6BA 1LX5B 4BIKB 1KTZB 1QKEA 2UWRA 1JBDA 1KBTA 2HLQA 1YWHA 2CCXA 1CXNA 2UX2A 1CCQA 1LXHA 1CDSA 4BDTB 1S4YA 1FRAA 1KC4A 1KFHA 1NORA 3NDSA 2QJAC 2H64C 3HH7A 1NYSA 2H7ZA 4XJJA 1MAHF 1KU6B 1NEAA 2J8BA 2MUPA 4AEAA 2JVEA 1HAJA 2QJBC 4QTIU 1IK8A 1HC9B 1FFJA 2X8BB 4UY2C 1RGJA 1CVOA 1IDGA 3ERAA 1ERAA 1CB9A 1IJCA 1CTXA 1FSSB 6EBXA 3NEQA 1KXIA 5DU1A 1PLOA 2MHYA 5IMYC 2ERAA 5IMTD 2PJYB 1BTEA 2CDXA 4LFTA 2VLWA 3BT1U 1COEA 2NBTA 2L5SA 1H0JA 5DO6A 1TXAA 2MJ4A 1IDLA 2H8UA 1CHVS 3EVSC 1IKCA 4P7UA 1I02A 1CODA 1JE9A 2N99A 2GOOC 1IDHA 3LAQU 2LCRA 3U74U 3VTSA 1HOYA 1XT3A 1FSCA 3KFDE 1ES7B 2OFSA 4FAOC 1G6MA 2CRTA 1CREA 1MR6A 2BHIA 1DRSA 1CDQA 1ABTA 4KSNA 1M9ZA 2L03A 1V6PA 4HQPF 1NTXA 1VB0A 1CXOA 1IQ9A 1B41B 1LSIA 1RL5A 2JQPA 2MFAA 2H5FA 1TFSA 4RUDA 4FAOE 4OM4A 2QC1A 1L4WA 1HC9A 2H64B 1NYUA 1ERGA 1IDIA 2MJ0A 2H7ZB 2FD6U 3NH7A 1JGKA 2MUOA 1CRFA 1KS6A 4OM5A 1BXPA 1UG4A 1ZADA 3KFDI 1HAAA 3BT2U 3PLCA 4IYEA 2H62D 2BTXA 3EBXA 4DO8A 2QJ9C 1FF4A 1KBAA 2PJYC 1ONJA 2CTXA 2ABXA 3FEVA 1NXBA 1F8UB 1CDRA 1FASA 2H62C 1KBSA 5DZ5A 5EBXA 2CRSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1REW C;  1KL8 A;  1QKD A;  1QM7 A;  3QB4 B;  1LXG A;  1TXB A;  4EY8 B;  1F94 A;  2MJY A;  2I9B E;  1LJZ A;  1NTN A;  2GOO B;  2K3G A;  3U73 U;  1CDT A;  4ZQY A;  1TGX A;  2HLR A;  2LA1 A;  1W6B A;  1LX5 B;  4BIK B;  1KTZ B;  1QKE A;  2UWR A;  1JBD A;  1KBT A;  2HLQ A;  1YWH A;  2CCX A;  1CXN A;  2UX2 A;  1CCQ A;  1LXH A;  1CDS A;  4BDT B;  1S4Y A;  1FRA A;  1KC4 A;  1KFH A;  1NOR A;  3NDS A;  2QJA C;  2H64 C;  3HH7 A;  1NYS A;  2H7Z A;  4XJJ A;  1MAH F;  1KU6 B;  1NEA A;  2J8B A;  2MUP A;  4AEA A;  2JVE A;  1HAJ A;  2QJB C;  4QTI U;  1IK8 A;  1HC9 B;  1FFJ A;  2X8B B;  4UY2 C;  1RGJ A;  1CVO A;  1IDG A;  3ERA A;  1ERA A;  1CB9 A;  1IJC A;  1CTX A;  1FSS B;  6EBX A;  3NEQ A;  1KXI A;  5DU1 A;  1PLO A;  2MHY A;  5IMY C;  2ERA A;  5IMT D;  2PJY B;  1BTE A;  2CDX A;  4LFT A;  2VLW A;  3BT1 U;  1COE A;  2NBT A;  2L5S A;  1H0J A;  5DO6 A;  1TXA A;  2MJ4 A;  1IDL A;  2H8U A;  1CHV S;  3EVS C;  1IKC A;  4P7U A;  1I02 A;  1COD A;  1JE9 A;  2N99 A;  2GOO C;  1IDH A;  3LAQ U;  2LCR A;  3U74 U;  3VTS A;  1HOY A;  1XT3 A;  1FSC A;  3KFD E;  1ES7 B;  2OFS A;  4FAO C;  1G6M A;  2CRT A;  1CRE A;  1MR6 A;  2BHI A;  1DRS A;  1CDQ A;  1ABT A;  1M9Z A;  2L03 A;  1V6P A;  4HQP F;  1NTX A;  1VB0 A;  1CXO A;  1IQ9 A;  1B41 B;  1LSI A;  1RL5 A;  2JQP A;  2MFA A;  2H5F A;  1TFS A;  4RUD A;  4FAO E;  4OM4 A;  2QC1 A;  1L4W A;  1HC9 A;  2H64 B;  1NYU A;  1ERG A;  1IDI A;  2MJ0 A;  2H7Z B;  2FD6 U;  3NH7 A;  1JGK A;  2MUO A;  1CRF A;  1KS6 A;  4OM5 A;  1BXP A;  1UG4 A;  1ZAD A;  3KFD I;  1HAA A;  3BT2 U;  3PLC A;  4IYE A;  2H62 D;  2BTX A;  3EBX A;  4DO8 A;  2QJ9 C;  1FF4 A;  1KBA A;  2PJY C;  1ONJ A;  2CTX A;  2ABX A;  3FEV A;  1NXB A;  1F8U B;  1CDR A;  1FAS A;  2H62 C;  1KBS A;  5DZ5 A;  5EBX A;  2CRS A; 
#chains in the Genus database with same CATH topology
 1REW C;  1KL8 A;  1QKD A;  1QM7 A;  3QB4 B;  1LXG A;  1TXB A;  4EY8 B;  1F94 A;  2MJY A;  2I9B E;  1LJZ A;  1NTN A;  2GOO B;  2K3G A;  3U73 U;  1CDT A;  4ZQY A;  1TGX A;  2HLR A;  2LA1 A;  1W6B A;  1LX5 B;  4BIK B;  1KTZ B;  1QKE A;  2UWR A;  1JBD A;  1KBT A;  2HLQ A;  1YWH A;  2CCX A;  1CXN A;  2UX2 A;  1CCQ A;  1LXH A;  1CDS A;  4BDT B;  1S4Y A;  1FRA A;  1KC4 A;  1KFH A;  1NOR A;  3NDS A;  2QJA C;  2H64 C;  3HH7 A;  1NYS A;  2H7Z A;  4XJJ A;  1MAH F;  1KU6 B;  1NEA A;  2J8B A;  2MUP A;  4AEA A;  2JVE A;  1HAJ A;  2QJB C;  4QTI U;  1IK8 A;  1HC9 B;  1FFJ A;  2X8B B;  4UY2 C;  1RGJ A;  1CVO A;  1IDG A;  3ERA A;  1ERA A;  1CB9 A;  1IJC A;  1CTX A;  1FSS B;  6EBX A;  3NEQ A;  1KXI A;  5DU1 A;  1PLO A;  2MHY A;  5IMY C;  2ERA A;  5IMT D;  2PJY B;  1BTE A;  2CDX A;  4LFT A;  2VLW A;  3BT1 U;  1COE A;  2NBT A;  2L5S A;  1H0J A;  5DO6 A;  1TXA A;  2MJ4 A;  1IDL A;  2H8U A;  1CHV S;  3EVS C;  1IKC A;  4P7U A;  1I02 A;  1COD A;  1JE9 A;  2N99 A;  2GOO C;  1IDH A;  3LAQ U;  2LCR A;  3U74 U;  3VTS A;  1HOY A;  1XT3 A;  1FSC A;  3KFD E;  1ES7 B;  2OFS A;  4FAO C;  1G6M A;  2CRT A;  1CRE A;  1MR6 A;  2BHI A;  1DRS A;  1CDQ A;  1ABT A;  4KSN A;  1M9Z A;  2L03 A;  1V6P A;  4HQP F;  1NTX A;  1VB0 A;  1CXO A;  1IQ9 A;  1B41 B;  1LSI A;  1RL5 A;  2JQP A;  2MFA A;  2H5F A;  1TFS A;  4RUD A;  4FAO E;  4OM4 A;  2QC1 A;  1L4W A;  1HC9 A;  2H64 B;  1NYU A;  1ERG A;  1IDI A;  2MJ0 A;  2H7Z B;  2FD6 U;  3NH7 A;  1JGK A;  2MUO A;  1CRF A;  1KS6 A;  4OM5 A;  1BXP A;  1UG4 A;  1ZAD A;  3KFD I;  1HAA A;  3BT2 U;  3PLC A;  4IYE A;  2H62 D;  2BTX A;  3EBX A;  4DO8 A;  2QJ9 C;  1FF4 A;  1KBA A;  2PJY C;  1ONJ A;  2CTX A;  2ABX A;  3FEV A;  1NXB A;  1F8U B;  1CDR A;  1FAS A;  2H62 C;  1KBS A;  5DZ5 A;  5EBX A;  2CRS A; 
#chains in the Genus database with same CATH homology
 1REW C;  1KL8 A;  1QKD A;  1QM7 A;  3QB4 B;  1LXG A;  1TXB A;  4EY8 B;  1F94 A;  2MJY A;  2I9B E;  1LJZ A;  1NTN A;  2GOO B;  2K3G A;  3U73 U;  1CDT A;  4ZQY A;  1TGX A;  2HLR A;  2LA1 A;  1W6B A;  1LX5 B;  4BIK B;  1KTZ B;  1QKE A;  2UWR A;  1JBD A;  1KBT A;  2HLQ A;  1YWH A;  2CCX A;  1CXN A;  2UX2 A;  1CCQ A;  1LXH A;  1CDS A;  4BDT B;  1S4Y A;  1FRA A;  1KC4 A;  1KFH A;  1NOR A;  3NDS A;  2QJA C;  2H64 C;  3HH7 A;  1NYS A;  2H7Z A;  4XJJ A;  1MAH F;  1KU6 B;  1NEA A;  2J8B A;  2MUP A;  4AEA A;  2JVE A;  1HAJ A;  2QJB C;  4QTI U;  1IK8 A;  1HC9 B;  1FFJ A;  2X8B B;  4UY2 C;  1RGJ A;  1CVO A;  1IDG A;  3ERA A;  1ERA A;  1CB9 A;  1IJC A;  1CTX A;  1FSS B;  6EBX A;  3NEQ A;  1KXI A;  5DU1 A;  1PLO A;  2MHY A;  5IMY C;  2ERA A;  5IMT D;  2PJY B;  1BTE A;  2CDX A;  4LFT A;  2VLW A;  3BT1 U;  1COE A;  2NBT A;  2L5S A;  1H0J A;  5DO6 A;  1TXA A;  2MJ4 A;  1IDL A;  2H8U A;  1CHV S;  3EVS C;  1IKC A;  4P7U A;  1I02 A;  1COD A;  1JE9 A;  2N99 A;  2GOO C;  1IDH A;  3LAQ U;  2LCR A;  3U74 U;  3VTS A;  1HOY A;  1XT3 A;  1FSC A;  3KFD E;  1ES7 B;  2OFS A;  4FAO C;  1G6M A;  2CRT A;  1CRE A;  1MR6 A;  2BHI A;  1DRS A;  1CDQ A;  1ABT A;  4KSN A;  1M9Z A;  2L03 A;  1V6P A;  4HQP F;  1NTX A;  1VB0 A;  1CXO A;  1IQ9 A;  1B41 B;  1LSI A;  1RL5 A;  2JQP A;  2MFA A;  2H5F A;  1TFS A;  4RUD A;  4FAO E;  4OM4 A;  2QC1 A;  1L4W A;  1HC9 A;  2H64 B;  1NYU A;  1ERG A;  1IDI A;  2MJ0 A;  2H7Z B;  2FD6 U;  3NH7 A;  1JGK A;  2MUO A;  1CRF A;  1KS6 A;  4OM5 A;  1BXP A;  1UG4 A;  1ZAD A;  3KFD I;  1HAA A;  3BT2 U;  3PLC A;  4IYE A;  2H62 D;  2BTX A;  3EBX A;  4DO8 A;  2QJ9 C;  1FF4 A;  1KBA A;  2PJY C;  1ONJ A;  2CTX A;  2ABX A;  3FEV A;  1NXB A;  1F8U B;  1CDR A;  1FAS A;  2H62 C;  1KBS A;  5DZ5 A;  5EBX A;  2CRS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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