4EY8B

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2
Total Genus 10
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Acetylcholinesterase
publication title Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2012-05-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4ey8B00
1JBDA 2MHYA 1H0JA 2MJ4A 1ZADA 4QTIU 4DO8A 1TGXA 3FEVA 1BTEA 1MR6A 2H62D 2MUPA 2L03A 1PLOA 1NTNA 1ERGA 1BXPA 2NBTA 2J8BA 1FRAA 1XT3A 1W6BA 3PLCA 1LX5B 1MAHF 2QC1A 1ERAA 2H64B 1RL5A 1CDRA 2LCRA 1G6MA 2VLWA 4FAOC 2BTXA 1F94A 2N99A 1CCQA 1CDTA 1QM7A 2JVEA 2H7ZB 2QJAC 4UY2C 2MJYA 3U74U 1CTXA 2K3GA 1REWC 2L5SA 3KFDI 3LAQU 4ZQYA 2HLQA 1CHVS 2GOOB 1RGJA 4XJJA 1COEA 2QJBC 1DRSA 6EBXA 1CRFA 1QKEA 1ES7B 4EY8B 1NTXA 1TFSA 2OFSA 1HC9A 2QJ9C 5IMYC 4BDTB 2HLRA 1HAJA 2UWRA 1FSCA 1S4YA 2UX2A 1IDGA 1KC4A 1KXIA 5DZ5A 2CCXA 1L4WA 3BT2U 1CDQA 1ONJA 1IJCA 2JQPA 1IQ9A 1TXAA 1LXHA 4P7UA 2CTXA 4IYEA 1TXBA 4HQPF 1JE9A 1CDSA 2I9BE 1KU6B 2H62C 3HH7A 1FASA 1ABTA 1KL8A 1QKDA 5IMTD 1HOYA 1NYSA 1CREA 1VB0A 5EBXA 2ABXA 2H8UA 2MFAA 1NXBA 2PJYB 1CXNA 1F8UB 1FSSB 3QB4B 3BT1U 4OM5A 1NYUA 3NEQA 1NORA 3VTSA 2CRSA 1CXOA 4LFTA 1LXGA 2MUOA 3KFDE 1KS6A 1IKCA 5DU1A 3U73U 1KBAA 1FFJA 1LSIA 1B41B 2ERAA 2H64C 1KFHA 1HAAA 1M9ZA 1IK8A 1JGKA 2LA1A 3NDSA 1CVOA 2H5FA 1KBSA 5DO6A 1IDHA 4AEAA 4BIKB 1LJZA 2H7ZA 4OM4A 1CB9A 1HC9B 4RUDA 3EVSC 1CODA 2CRTA 2CDXA 1IDIA 2MJ0A 1YWHA 2FD6U 4FAOE 3EBXA 1NEAA 1KBTA 1FF4A 1UG4A 2X8BB 2BHIA 2GOOC 3NH7A 1IDLA 1KTZB 1V6PA 2PJYC 3ERAA 1I02A
chains in the Genus database with same CATH superfamily
4KSNA 1JBDA 2MHYA 1H0JA 2MJ4A 1ZADA 4QTIU 4DO8A 1TGXA 3FEVA 1BTEA 1MR6A 2H62D 2MUPA 2L03A 1PLOA 1NTNA 1ERGA 1BXPA 2NBTA 2J8BA 1FRAA 1XT3A 1W6BA 3PLCA 1LX5B 1MAHF 2QC1A 1ERAA 2H64B 1RL5A 1CDRA 2LCRA 1G6MA 2VLWA 4FAOC 2BTXA 1F94A 2N99A 1CCQA 1CDTA 1QM7A 2JVEA 2H7ZB 2QJAC 4UY2C 2MJYA 3U74U 1CTXA 2K3GA 1REWC 2L5SA 3KFDI 3LAQU 4ZQYA 2HLQA 1CHVS 2GOOB 1RGJA 4XJJA 1COEA 2QJBC 1DRSA 6EBXA 1CRFA 1QKEA 1ES7B 4EY8B 1NTXA 1TFSA 2OFSA 1HC9A 2QJ9C 5IMYC 4BDTB 2HLRA 1HAJA 2UWRA 1FSCA 1S4YA 2UX2A 1IDGA 1KC4A 1KXIA 5DZ5A 2CCXA 1L4WA 3BT2U 1CDQA 1ONJA 1IJCA 2JQPA 1IQ9A 1TXAA 1LXHA 4P7UA 2CTXA 4IYEA 1TXBA 4HQPF 1JE9A 1CDSA 2I9BE 1KU6B 2H62C 3HH7A 1FASA 1ABTA 1KL8A 1QKDA 5IMTD 1HOYA 1NYSA 1CREA 1VB0A 5EBXA 2ABXA 2H8UA 2MFAA 1NXBA 2PJYB 1CXNA 1F8UB 1FSSB 3QB4B 3BT1U 4OM5A 1NYUA 3NEQA 1NORA 3VTSA 2CRSA 1CXOA 4LFTA 1LXGA 2MUOA 3KFDE 1KS6A 1IKCA 5DU1A 3U73U 1KBAA 1FFJA 1LSIA 1B41B 2ERAA 2H64C 1KFHA 1HAAA 1M9ZA 1IK8A 1JGKA 2LA1A 3NDSA 1CVOA 2H5FA 1KBSA 5DO6A 1IDHA 4AEAA 4BIKB 1LJZA 2H7ZA 4OM4A 1CB9A 1HC9B 4RUDA 3EVSC 1CODA 2CRTA 2CDXA 1IDIA 2MJ0A 1YWHA 2FD6U 4FAOE 3EBXA 1NEAA 1KBTA 1FF4A 1UG4A 2X8BB 2BHIA 2GOOC 3NH7A 1IDLA 1KTZB 1V6PA 2PJYC 3ERAA 1I02A
chains in the Genus database with same CATH topology
4KSNA 1JBDA 2MHYA 1H0JA 2MJ4A 1ZADA 4QTIU 4DO8A 1TGXA 3FEVA 1BTEA 1MR6A 2H62D 2MUPA 2L03A 1PLOA 1NTNA 1ERGA 1BXPA 2NBTA 2J8BA 1FRAA 1XT3A 1W6BA 3PLCA 1LX5B 1MAHF 2QC1A 1ERAA 2H64B 1RL5A 1CDRA 2LCRA 1G6MA 2VLWA 4FAOC 2BTXA 1F94A 2N99A 1CCQA 1CDTA 1QM7A 2JVEA 2H7ZB 2QJAC 4UY2C 2MJYA 3U74U 1CTXA 2K3GA 1REWC 2L5SA 3KFDI 3LAQU 4ZQYA 2HLQA 1CHVS 2GOOB 1RGJA 4XJJA 1COEA 2QJBC 1DRSA 6EBXA 1CRFA 1QKEA 1ES7B 4EY8B 1NTXA 1TFSA 2OFSA 1HC9A 2QJ9C 5IMYC 4BDTB 2HLRA 1HAJA 2UWRA 1FSCA 1S4YA 2UX2A 1IDGA 1KC4A 1KXIA 5DZ5A 2CCXA 1L4WA 3BT2U 1CDQA 1ONJA 1IJCA 2JQPA 1IQ9A 1TXAA 1LXHA 4P7UA 2CTXA 4IYEA 1TXBA 4HQPF 1JE9A 1CDSA 2I9BE 1KU6B 2H62C 3HH7A 1FASA 1ABTA 1KL8A 1QKDA 5IMTD 1HOYA 1NYSA 1CREA 1VB0A 5EBXA 2ABXA 2H8UA 2MFAA 1NXBA 2PJYB 1CXNA 1F8UB 1FSSB 3QB4B 3BT1U 4OM5A 1NYUA 3NEQA 1NORA 3VTSA 2CRSA 1CXOA 4LFTA 1LXGA 2MUOA 3KFDE 1KS6A 1IKCA 5DU1A 3U73U 1KBAA 1FFJA 1LSIA 1B41B 2ERAA 2H64C 1KFHA 1HAAA 1M9ZA 1IK8A 1JGKA 2LA1A 3NDSA 1CVOA 2H5FA 1KBSA 5DO6A 1IDHA 4AEAA 4BIKB 1LJZA 2H7ZA 4OM4A 1CB9A 1HC9B 4RUDA 3EVSC 1CODA 2CRTA 2CDXA 1IDIA 2MJ0A 1YWHA 2FD6U 4FAOE 3EBXA 1NEAA 1KBTA 1FF4A 1UG4A 2X8BB 2BHIA 2GOOC 3NH7A 1IDLA 1KTZB 1V6PA 2PJYC 3ERAA 1I02A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JBD A;  2MHY A;  1H0J A;  2MJ4 A;  1ZAD A;  4QTI U;  4DO8 A;  1TGX A;  3FEV A;  1BTE A;  1MR6 A;  2H62 D;  2MUP A;  2L03 A;  1PLO A;  1NTN A;  1ERG A;  1BXP A;  2NBT A;  2J8B A;  1FRA A;  1XT3 A;  1W6B A;  3PLC A;  1LX5 B;  1MAH F;  2QC1 A;  1ERA A;  2H64 B;  1RL5 A;  1CDR A;  2LCR A;  1G6M A;  2VLW A;  4FAO C;  2BTX A;  1F94 A;  2N99 A;  1CCQ A;  1CDT A;  1QM7 A;  2JVE A;  2H7Z B;  2QJA C;  4UY2 C;  2MJY A;  3U74 U;  1CTX A;  2K3G A;  1REW C;  2L5S A;  3KFD I;  3LAQ U;  4ZQY A;  2HLQ A;  1CHV S;  2GOO B;  1RGJ A;  4XJJ A;  1COE A;  2QJB C;  1DRS A;  6EBX A;  1CRF A;  1QKE A;  1ES7 B;  4EY8 B;  1NTX A;  1TFS A;  2OFS A;  1HC9 A;  2QJ9 C;  5IMY C;  4BDT B;  2HLR A;  1HAJ A;  2UWR A;  1FSC A;  1S4Y A;  2UX2 A;  1IDG A;  1KC4 A;  1KXI A;  5DZ5 A;  2CCX A;  1L4W A;  3BT2 U;  1CDQ A;  1ONJ A;  1IJC A;  2JQP A;  1IQ9 A;  1TXA A;  1LXH A;  4P7U A;  2CTX A;  4IYE A;  1TXB A;  4HQP F;  1JE9 A;  1CDS A;  2I9B E;  1KU6 B;  2H62 C;  3HH7 A;  1FAS A;  1ABT A;  1KL8 A;  1QKD A;  5IMT D;  1HOY A;  1NYS A;  1CRE A;  1VB0 A;  5EBX A;  2ABX A;  2H8U A;  2MFA A;  1NXB A;  2PJY B;  1CXN A;  1F8U B;  1FSS B;  3QB4 B;  3BT1 U;  4OM5 A;  1NYU A;  3NEQ A;  1NOR A;  3VTS A;  2CRS A;  1CXO A;  4LFT A;  1LXG A;  2MUO A;  3KFD E;  1KS6 A;  1IKC A;  5DU1 A;  3U73 U;  1KBA A;  1FFJ A;  1LSI A;  1B41 B;  2ERA A;  2H64 C;  1KFH A;  1HAA A;  1M9Z A;  1IK8 A;  1JGK A;  2LA1 A;  3NDS A;  1CVO A;  2H5F A;  1KBS A;  5DO6 A;  1IDH A;  4AEA A;  4BIK B;  1LJZ A;  2H7Z A;  4OM4 A;  1CB9 A;  1HC9 B;  4RUD A;  3EVS C;  1COD A;  2CRT A;  2CDX A;  1IDI A;  2MJ0 A;  1YWH A;  2FD6 U;  4FAO E;  3EBX A;  1NEA A;  1KBT A;  1FF4 A;  1UG4 A;  2X8B B;  2BHI A;  2GOO C;  3NH7 A;  1IDL A;  1KTZ B;  1V6P A;  2PJY C;  3ERA A;  1I02 A; 
#chains in the Genus database with same CATH topology
 4KSN A;  1JBD A;  2MHY A;  1H0J A;  2MJ4 A;  1ZAD A;  4QTI U;  4DO8 A;  1TGX A;  3FEV A;  1BTE A;  1MR6 A;  2H62 D;  2MUP A;  2L03 A;  1PLO A;  1NTN A;  1ERG A;  1BXP A;  2NBT A;  2J8B A;  1FRA A;  1XT3 A;  1W6B A;  3PLC A;  1LX5 B;  1MAH F;  2QC1 A;  1ERA A;  2H64 B;  1RL5 A;  1CDR A;  2LCR A;  1G6M A;  2VLW A;  4FAO C;  2BTX A;  1F94 A;  2N99 A;  1CCQ A;  1CDT A;  1QM7 A;  2JVE A;  2H7Z B;  2QJA C;  4UY2 C;  2MJY A;  3U74 U;  1CTX A;  2K3G A;  1REW C;  2L5S A;  3KFD I;  3LAQ U;  4ZQY A;  2HLQ A;  1CHV S;  2GOO B;  1RGJ A;  4XJJ A;  1COE A;  2QJB C;  1DRS A;  6EBX A;  1CRF A;  1QKE A;  1ES7 B;  4EY8 B;  1NTX A;  1TFS A;  2OFS A;  1HC9 A;  2QJ9 C;  5IMY C;  4BDT B;  2HLR A;  1HAJ A;  2UWR A;  1FSC A;  1S4Y A;  2UX2 A;  1IDG A;  1KC4 A;  1KXI A;  5DZ5 A;  2CCX A;  1L4W A;  3BT2 U;  1CDQ A;  1ONJ A;  1IJC A;  2JQP A;  1IQ9 A;  1TXA A;  1LXH A;  4P7U A;  2CTX A;  4IYE A;  1TXB A;  4HQP F;  1JE9 A;  1CDS A;  2I9B E;  1KU6 B;  2H62 C;  3HH7 A;  1FAS A;  1ABT A;  1KL8 A;  1QKD A;  5IMT D;  1HOY A;  1NYS A;  1CRE A;  1VB0 A;  5EBX A;  2ABX A;  2H8U A;  2MFA A;  1NXB A;  2PJY B;  1CXN A;  1F8U B;  1FSS B;  3QB4 B;  3BT1 U;  4OM5 A;  1NYU A;  3NEQ A;  1NOR A;  3VTS A;  2CRS A;  1CXO A;  4LFT A;  1LXG A;  2MUO A;  3KFD E;  1KS6 A;  1IKC A;  5DU1 A;  3U73 U;  1KBA A;  1FFJ A;  1LSI A;  1B41 B;  2ERA A;  2H64 C;  1KFH A;  1HAA A;  1M9Z A;  1IK8 A;  1JGK A;  2LA1 A;  3NDS A;  1CVO A;  2H5F A;  1KBS A;  5DO6 A;  1IDH A;  4AEA A;  4BIK B;  1LJZ A;  2H7Z A;  4OM4 A;  1CB9 A;  1HC9 B;  4RUD A;  3EVS C;  1COD A;  2CRT A;  2CDX A;  1IDI A;  2MJ0 A;  1YWH A;  2FD6 U;  4FAO E;  3EBX A;  1NEA A;  1KBT A;  1FF4 A;  1UG4 A;  2X8B B;  2BHI A;  2GOO C;  3NH7 A;  1IDL A;  1KTZ B;  1V6P A;  2PJY C;  3ERA A;  1I02 A; 
#chains in the Genus database with same CATH homology
 4KSN A;  1JBD A;  2MHY A;  1H0J A;  2MJ4 A;  1ZAD A;  4QTI U;  4DO8 A;  1TGX A;  3FEV A;  1BTE A;  1MR6 A;  2H62 D;  2MUP A;  2L03 A;  1PLO A;  1NTN A;  1ERG A;  1BXP A;  2NBT A;  2J8B A;  1FRA A;  1XT3 A;  1W6B A;  3PLC A;  1LX5 B;  1MAH F;  2QC1 A;  1ERA A;  2H64 B;  1RL5 A;  1CDR A;  2LCR A;  1G6M A;  2VLW A;  4FAO C;  2BTX A;  1F94 A;  2N99 A;  1CCQ A;  1CDT A;  1QM7 A;  2JVE A;  2H7Z B;  2QJA C;  4UY2 C;  2MJY A;  3U74 U;  1CTX A;  2K3G A;  1REW C;  2L5S A;  3KFD I;  3LAQ U;  4ZQY A;  2HLQ A;  1CHV S;  2GOO B;  1RGJ A;  4XJJ A;  1COE A;  2QJB C;  1DRS A;  6EBX A;  1CRF A;  1QKE A;  1ES7 B;  4EY8 B;  1NTX A;  1TFS A;  2OFS A;  1HC9 A;  2QJ9 C;  5IMY C;  4BDT B;  2HLR A;  1HAJ A;  2UWR A;  1FSC A;  1S4Y A;  2UX2 A;  1IDG A;  1KC4 A;  1KXI A;  5DZ5 A;  2CCX A;  1L4W A;  3BT2 U;  1CDQ A;  1ONJ A;  1IJC A;  2JQP A;  1IQ9 A;  1TXA A;  1LXH A;  4P7U A;  2CTX A;  4IYE A;  1TXB A;  4HQP F;  1JE9 A;  1CDS A;  2I9B E;  1KU6 B;  2H62 C;  3HH7 A;  1FAS A;  1ABT A;  1KL8 A;  1QKD A;  5IMT D;  1HOY A;  1NYS A;  1CRE A;  1VB0 A;  5EBX A;  2ABX A;  2H8U A;  2MFA A;  1NXB A;  2PJY B;  1CXN A;  1F8U B;  1FSS B;  3QB4 B;  3BT1 U;  4OM5 A;  1NYU A;  3NEQ A;  1NOR A;  3VTS A;  2CRS A;  1CXO A;  4LFT A;  1LXG A;  2MUO A;  3KFD E;  1KS6 A;  1IKC A;  5DU1 A;  3U73 U;  1KBA A;  1FFJ A;  1LSI A;  1B41 B;  2ERA A;  2H64 C;  1KFH A;  1HAA A;  1M9Z A;  1IK8 A;  1JGK A;  2LA1 A;  3NDS A;  1CVO A;  2H5F A;  1KBS A;  5DO6 A;  1IDH A;  4AEA A;  4BIK B;  1LJZ A;  2H7Z A;  4OM4 A;  1CB9 A;  1HC9 B;  4RUD A;  3EVS C;  1COD A;  2CRT A;  2CDX A;  1IDI A;  2MJ0 A;  1YWH A;  2FD6 U;  4FAO E;  3EBX A;  1NEA A;  1KBT A;  1FF4 A;  1UG4 A;  2X8B B;  2BHI A;  2GOO C;  3NH7 A;  1IDL A;  1KTZ B;  1V6P A;  2PJY C;  3ERA A;  1I02 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...