4HQPF

Alpha7 nicotinic receptor chimera and its complex with alpha bungarotoxin
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
73
structure length
73
Chain Sequence
IVCHTTATSPISAVTCPPGENLCYRKMWCDVFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural principles for Alpha-neurotoxin binding to and selectivity among nicotinic receptors
rcsb
molecule keywords Alpha7 nicotinic receptor chimera
molecule tags Protein binding
source organism Homo sapiens, lymnaea stagnalis
total genus 8
structure length 73
sequence length 73
chains with identical sequence G, H, I, J
ec nomenclature
pdb deposition date 2012-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00087 Toxin_TOLIP Snake toxin and toxin-like protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4hqpF00
4LFTA 2PJYB 1FSCA 3U74U 3KFDI 1CXOA 2H7ZA 1CDSA 4IYEA 1CDQA 2N99A 3PLCA 3ERAA 3EBXA 1DRSA 1XT3A 1HAAA 2JVEA 2LA1A 1NXBA 3HH7A 4XJJA 1TXBA 5DZ5A 2MJ0A 2H62C 1KBSA 2H64C 2UWRA 2MFAA 1F94A 2BHIA 5DO6A 1KBAA 1LJZA 2I9BE 1KBTA 2L03A 2H5FA 4BIKB 4EY8B 3VTSA 1IKCA 1HC9A 2MJ4A 1B41B 1NYUA 1FSSB 1KTZB 1V6PA 2H7ZB 2L5SA 1CHVS 1JBDA 2QJAC 6EBXA 1ES7B 1QM7A 1PLOA 1BTEA 1ONJA 2H62D 1IDIA 1TGXA 1FF4A 1IDLA 1ABTA 1IJCA 2K3GA 1FRAA 5EBXA 1TFSA 4RUDA 1KXIA 1MR6A 2H64B 3EVSC 1W6BA 1TXAA 2CRSA 4FAOC 5DU1A 1LXGA 1CODA 1HOYA 1NEAA 2ERAA 1HC9B 3BT2U 3BT1U 4OM4A 1UG4A 2CTXA 2HLQA 5IMTD 1RGJA 2BTXA 2VLWA 2MJYA 3U73U 1CDRA 1CVOA 1KFHA 4FAOE 1MAHF 1CREA 2JQPA 1CXNA 1H0JA 1LSIA 1QKEA 4OM5A 4UY2C 3NEQA 2MUPA 2HLRA 4P7UA 1IDHA 2MHYA 1FASA 3NDSA 1I02A 1KS6A 2LCRA 1BXPA 1COEA 3FEVA 1IDGA 1YWHA 1KL8A 3QB4B 2PJYC 1F8UB 2CCXA 2GOOC 1CB9A 4DO8A 2GOOB 1RL5A 1HAJA 1LX5B 1NYSA 1NORA 1ZADA 2QJBC 1IQ9A 1IK8A 2CRTA 2NBTA 1CDTA 1KC4A 1NTNA 1ERAA 3NH7A 1CCQA 1G6MA 2QC1A 1NTXA 1VB0A 1JGKA 2FD6U 2UX2A 1QKDA 2J8BA 1S4YA 3LAQU 2ABXA 1LXHA 1KU6B 4ZQYA 2MUOA 4AEAA 4BDTB 1CRFA 5IMYC 1FFJA 1M9ZA 1REWC 2CDXA 1ERGA 2QJ9C 1CTXA 2OFSA 4QTIU 1JE9A 4HQPF 1L4WA 3KFDE 2H8UA 2X8BB
chains in the Genus database with same CATH superfamily
4LFTA 4KSNA 2PJYB 1FSCA 3U74U 3KFDI 1CXOA 2H7ZA 1CDSA 4IYEA 1CDQA 2N99A 3PLCA 3ERAA 3EBXA 1DRSA 1XT3A 1HAAA 2JVEA 2LA1A 1NXBA 3HH7A 4XJJA 1TXBA 5DZ5A 2MJ0A 2H62C 1KBSA 2H64C 2UWRA 2MFAA 1F94A 2BHIA 5DO6A 1KBAA 1LJZA 2I9BE 1KBTA 2L03A 2H5FA 4BIKB 4EY8B 3VTSA 1IKCA 1HC9A 2MJ4A 1B41B 1NYUA 1FSSB 1KTZB 1V6PA 2H7ZB 2L5SA 1CHVS 1JBDA 2QJAC 6EBXA 1ES7B 1QM7A 1PLOA 1BTEA 1ONJA 2H62D 1IDIA 1TGXA 1FF4A 1IDLA 1ABTA 1IJCA 2K3GA 1FRAA 5EBXA 1TFSA 4RUDA 1KXIA 1MR6A 2H64B 3EVSC 1W6BA 1TXAA 2CRSA 4FAOC 5DU1A 1LXGA 1CODA 1HOYA 1NEAA 2ERAA 1HC9B 3BT2U 3BT1U 4OM4A 1UG4A 2CTXA 2HLQA 5IMTD 1RGJA 2BTXA 2VLWA 2MJYA 3U73U 1CDRA 1CVOA 1KFHA 4FAOE 1MAHF 1CREA 2JQPA 1CXNA 1H0JA 1LSIA 1QKEA 4OM5A 4UY2C 3NEQA 2MUPA 2HLRA 4P7UA 1IDHA 2MHYA 1FASA 3NDSA 1I02A 1KS6A 2LCRA 1BXPA 1COEA 3FEVA 1IDGA 1YWHA 1KL8A 3QB4B 2PJYC 1F8UB 2CCXA 2GOOC 1CB9A 4DO8A 2GOOB 1RL5A 1HAJA 1LX5B 1NYSA 1NORA 1ZADA 2QJBC 1IQ9A 1IK8A 2CRTA 2NBTA 1CDTA 1KC4A 1NTNA 1ERAA 3NH7A 1CCQA 1G6MA 2QC1A 1NTXA 1VB0A 1JGKA 2FD6U 2UX2A 1QKDA 2J8BA 1S4YA 3LAQU 2ABXA 1LXHA 1KU6B 4ZQYA 2MUOA 4AEAA 4BDTB 1CRFA 5IMYC 1FFJA 1M9ZA 1REWC 2CDXA 1ERGA 2QJ9C 1CTXA 2OFSA 4QTIU 1JE9A 4HQPF 1L4WA 3KFDE 2H8UA 2X8BB
chains in the Genus database with same CATH topology
4LFTA 4KSNA 2PJYB 1FSCA 3U74U 3KFDI 1CXOA 2H7ZA 1CDSA 4IYEA 1CDQA 2N99A 3PLCA 3ERAA 3EBXA 1DRSA 1XT3A 1HAAA 2JVEA 2LA1A 1NXBA 3HH7A 4XJJA 1TXBA 5DZ5A 2MJ0A 2H62C 1KBSA 2H64C 2UWRA 2MFAA 1F94A 2BHIA 5DO6A 1KBAA 1LJZA 2I9BE 1KBTA 2L03A 2H5FA 4BIKB 4EY8B 3VTSA 1IKCA 1HC9A 2MJ4A 1B41B 1NYUA 1FSSB 1KTZB 1V6PA 2H7ZB 2L5SA 1CHVS 1JBDA 2QJAC 6EBXA 1ES7B 1QM7A 1PLOA 1BTEA 1ONJA 2H62D 1IDIA 1TGXA 1FF4A 1IDLA 1ABTA 1IJCA 2K3GA 1FRAA 5EBXA 1TFSA 4RUDA 1KXIA 1MR6A 2H64B 3EVSC 1W6BA 1TXAA 2CRSA 4FAOC 5DU1A 1LXGA 1CODA 1HOYA 1NEAA 2ERAA 1HC9B 3BT2U 3BT1U 4OM4A 1UG4A 2CTXA 2HLQA 5IMTD 1RGJA 2BTXA 2VLWA 2MJYA 3U73U 1CDRA 1CVOA 1KFHA 4FAOE 1MAHF 1CREA 2JQPA 1CXNA 1H0JA 1LSIA 1QKEA 4OM5A 4UY2C 3NEQA 2MUPA 2HLRA 4P7UA 1IDHA 2MHYA 1FASA 3NDSA 1I02A 1KS6A 2LCRA 1BXPA 1COEA 3FEVA 1IDGA 1YWHA 1KL8A 3QB4B 2PJYC 1F8UB 2CCXA 2GOOC 1CB9A 4DO8A 2GOOB 1RL5A 1HAJA 1LX5B 1NYSA 1NORA 1ZADA 2QJBC 1IQ9A 1IK8A 2CRTA 2NBTA 1CDTA 1KC4A 1NTNA 1ERAA 3NH7A 1CCQA 1G6MA 2QC1A 1NTXA 1VB0A 1JGKA 2FD6U 2UX2A 1QKDA 2J8BA 1S4YA 3LAQU 2ABXA 1LXHA 1KU6B 4ZQYA 2MUOA 4AEAA 4BDTB 1CRFA 5IMYC 1FFJA 1M9ZA 1REWC 2CDXA 1ERGA 2QJ9C 1CTXA 2OFSA 4QTIU 1JE9A 4HQPF 1L4WA 3KFDE 2H8UA 2X8BB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LFT A;  2PJY B;  1FSC A;  3U74 U;  3KFD I;  1CXO A;  2H7Z A;  1CDS A;  4IYE A;  1CDQ A;  2N99 A;  3PLC A;  3ERA A;  3EBX A;  1DRS A;  1XT3 A;  1HAA A;  2JVE A;  2LA1 A;  1NXB A;  3HH7 A;  4XJJ A;  1TXB A;  5DZ5 A;  2MJ0 A;  2H62 C;  1KBS A;  2H64 C;  2UWR A;  2MFA A;  1F94 A;  2BHI A;  5DO6 A;  1KBA A;  1LJZ A;  2I9B E;  1KBT A;  2L03 A;  2H5F A;  4BIK B;  4EY8 B;  3VTS A;  1IKC A;  1HC9 A;  2MJ4 A;  1B41 B;  1NYU A;  1FSS B;  1KTZ B;  1V6P A;  2H7Z B;  2L5S A;  1CHV S;  1JBD A;  2QJA C;  6EBX A;  1ES7 B;  1QM7 A;  1PLO A;  1BTE A;  1ONJ A;  2H62 D;  1IDI A;  1TGX A;  1FF4 A;  1IDL A;  1ABT A;  1IJC A;  2K3G A;  1FRA A;  5EBX A;  1TFS A;  4RUD A;  1KXI A;  1MR6 A;  2H64 B;  3EVS C;  1W6B A;  1TXA A;  2CRS A;  4FAO C;  5DU1 A;  1LXG A;  1COD A;  1HOY A;  1NEA A;  2ERA A;  1HC9 B;  3BT2 U;  3BT1 U;  4OM4 A;  1UG4 A;  2CTX A;  2HLQ A;  5IMT D;  1RGJ A;  2BTX A;  2VLW A;  2MJY A;  3U73 U;  1CDR A;  1CVO A;  1KFH A;  4FAO E;  1MAH F;  1CRE A;  2JQP A;  1CXN A;  1H0J A;  1LSI A;  1QKE A;  4OM5 A;  4UY2 C;  3NEQ A;  2MUP A;  2HLR A;  4P7U A;  1IDH A;  2MHY A;  1FAS A;  3NDS A;  1I02 A;  1KS6 A;  2LCR A;  1BXP A;  1COE A;  3FEV A;  1IDG A;  1YWH A;  1KL8 A;  3QB4 B;  2PJY C;  1F8U B;  2CCX A;  2GOO C;  1CB9 A;  4DO8 A;  2GOO B;  1RL5 A;  1HAJ A;  1LX5 B;  1NYS A;  1NOR A;  1ZAD A;  2QJB C;  1IQ9 A;  1IK8 A;  2CRT A;  2NBT A;  1CDT A;  1KC4 A;  1NTN A;  1ERA A;  3NH7 A;  1CCQ A;  1G6M A;  2QC1 A;  1NTX A;  1VB0 A;  1JGK A;  2FD6 U;  2UX2 A;  1QKD A;  2J8B A;  1S4Y A;  3LAQ U;  2ABX A;  1LXH A;  1KU6 B;  4ZQY A;  2MUO A;  4AEA A;  4BDT B;  1CRF A;  5IMY C;  1FFJ A;  1M9Z A;  1REW C;  2CDX A;  1ERG A;  2QJ9 C;  1CTX A;  2OFS A;  4QTI U;  1JE9 A;  4HQP F;  1L4W A;  3KFD E;  2H8U A;  2X8B B; 
#chains in the Genus database with same CATH topology
 4LFT A;  4KSN A;  2PJY B;  1FSC A;  3U74 U;  3KFD I;  1CXO A;  2H7Z A;  1CDS A;  4IYE A;  1CDQ A;  2N99 A;  3PLC A;  3ERA A;  3EBX A;  1DRS A;  1XT3 A;  1HAA A;  2JVE A;  2LA1 A;  1NXB A;  3HH7 A;  4XJJ A;  1TXB A;  5DZ5 A;  2MJ0 A;  2H62 C;  1KBS A;  2H64 C;  2UWR A;  2MFA A;  1F94 A;  2BHI A;  5DO6 A;  1KBA A;  1LJZ A;  2I9B E;  1KBT A;  2L03 A;  2H5F A;  4BIK B;  4EY8 B;  3VTS A;  1IKC A;  1HC9 A;  2MJ4 A;  1B41 B;  1NYU A;  1FSS B;  1KTZ B;  1V6P A;  2H7Z B;  2L5S A;  1CHV S;  1JBD A;  2QJA C;  6EBX A;  1ES7 B;  1QM7 A;  1PLO A;  1BTE A;  1ONJ A;  2H62 D;  1IDI A;  1TGX A;  1FF4 A;  1IDL A;  1ABT A;  1IJC A;  2K3G A;  1FRA A;  5EBX A;  1TFS A;  4RUD A;  1KXI A;  1MR6 A;  2H64 B;  3EVS C;  1W6B A;  1TXA A;  2CRS A;  4FAO C;  5DU1 A;  1LXG A;  1COD A;  1HOY A;  1NEA A;  2ERA A;  1HC9 B;  3BT2 U;  3BT1 U;  4OM4 A;  1UG4 A;  2CTX A;  2HLQ A;  5IMT D;  1RGJ A;  2BTX A;  2VLW A;  2MJY A;  3U73 U;  1CDR A;  1CVO A;  1KFH A;  4FAO E;  1MAH F;  1CRE A;  2JQP A;  1CXN A;  1H0J A;  1LSI A;  1QKE A;  4OM5 A;  4UY2 C;  3NEQ A;  2MUP A;  2HLR A;  4P7U A;  1IDH A;  2MHY A;  1FAS A;  3NDS A;  1I02 A;  1KS6 A;  2LCR A;  1BXP A;  1COE A;  3FEV A;  1IDG A;  1YWH A;  1KL8 A;  3QB4 B;  2PJY C;  1F8U B;  2CCX A;  2GOO C;  1CB9 A;  4DO8 A;  2GOO B;  1RL5 A;  1HAJ A;  1LX5 B;  1NYS A;  1NOR A;  1ZAD A;  2QJB C;  1IQ9 A;  1IK8 A;  2CRT A;  2NBT A;  1CDT A;  1KC4 A;  1NTN A;  1ERA A;  3NH7 A;  1CCQ A;  1G6M A;  2QC1 A;  1NTX A;  1VB0 A;  1JGK A;  2FD6 U;  2UX2 A;  1QKD A;  2J8B A;  1S4Y A;  3LAQ U;  2ABX A;  1LXH A;  1KU6 B;  4ZQY A;  2MUO A;  4AEA A;  4BDT B;  1CRF A;  5IMY C;  1FFJ A;  1M9Z A;  1REW C;  2CDX A;  1ERG A;  2QJ9 C;  1CTX A;  2OFS A;  4QTI U;  1JE9 A;  4HQP F;  1L4W A;  3KFD E;  2H8U A;  2X8B B; 
#chains in the Genus database with same CATH homology
 4LFT A;  4KSN A;  2PJY B;  1FSC A;  3U74 U;  3KFD I;  1CXO A;  2H7Z A;  1CDS A;  4IYE A;  1CDQ A;  2N99 A;  3PLC A;  3ERA A;  3EBX A;  1DRS A;  1XT3 A;  1HAA A;  2JVE A;  2LA1 A;  1NXB A;  3HH7 A;  4XJJ A;  1TXB A;  5DZ5 A;  2MJ0 A;  2H62 C;  1KBS A;  2H64 C;  2UWR A;  2MFA A;  1F94 A;  2BHI A;  5DO6 A;  1KBA A;  1LJZ A;  2I9B E;  1KBT A;  2L03 A;  2H5F A;  4BIK B;  4EY8 B;  3VTS A;  1IKC A;  1HC9 A;  2MJ4 A;  1B41 B;  1NYU A;  1FSS B;  1KTZ B;  1V6P A;  2H7Z B;  2L5S A;  1CHV S;  1JBD A;  2QJA C;  6EBX A;  1ES7 B;  1QM7 A;  1PLO A;  1BTE A;  1ONJ A;  2H62 D;  1IDI A;  1TGX A;  1FF4 A;  1IDL A;  1ABT A;  1IJC A;  2K3G A;  1FRA A;  5EBX A;  1TFS A;  4RUD A;  1KXI A;  1MR6 A;  2H64 B;  3EVS C;  1W6B A;  1TXA A;  2CRS A;  4FAO C;  5DU1 A;  1LXG A;  1COD A;  1HOY A;  1NEA A;  2ERA A;  1HC9 B;  3BT2 U;  3BT1 U;  4OM4 A;  1UG4 A;  2CTX A;  2HLQ A;  5IMT D;  1RGJ A;  2BTX A;  2VLW A;  2MJY A;  3U73 U;  1CDR A;  1CVO A;  1KFH A;  4FAO E;  1MAH F;  1CRE A;  2JQP A;  1CXN A;  1H0J A;  1LSI A;  1QKE A;  4OM5 A;  4UY2 C;  3NEQ A;  2MUP A;  2HLR A;  4P7U A;  1IDH A;  2MHY A;  1FAS A;  3NDS A;  1I02 A;  1KS6 A;  2LCR A;  1BXP A;  1COE A;  3FEV A;  1IDG A;  1YWH A;  1KL8 A;  3QB4 B;  2PJY C;  1F8U B;  2CCX A;  2GOO C;  1CB9 A;  4DO8 A;  2GOO B;  1RL5 A;  1HAJ A;  1LX5 B;  1NYS A;  1NOR A;  1ZAD A;  2QJB C;  1IQ9 A;  1IK8 A;  2CRT A;  2NBT A;  1CDT A;  1KC4 A;  1NTN A;  1ERA A;  3NH7 A;  1CCQ A;  1G6M A;  2QC1 A;  1NTX A;  1VB0 A;  1JGK A;  2FD6 U;  2UX2 A;  1QKD A;  2J8B A;  1S4Y A;  3LAQ U;  2ABX A;  1LXH A;  1KU6 B;  4ZQY A;  2MUO A;  4AEA A;  4BDT B;  1CRF A;  5IMY C;  1FFJ A;  1M9Z A;  1REW C;  2CDX A;  1ERG A;  2QJ9 C;  1CTX A;  2OFS A;  4QTI U;  1JE9 A;  4HQP F;  1L4W A;  3KFD E;  2H8U A;  2X8B B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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