4DO8A

Crystal structure of the muscarinic toxin mt1
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
66
structure length
66
Chain Sequence
LTCVTSKSIFGITTENCPDGQNLCFKKWYYIVPRYSDITWGCAATCPKPTNVRETIRCCETDKCNE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
pubmed doi rcsb
molecule keywords Muscarinic toxin 1
molecule tags Toxin
total genus 11
structure length 66
sequence length 66
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00087 Toxin_TOLIP Snake toxin and toxin-like protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 4do8A00
2HLQA 4FAOE 2MJ4A 1MR6A 5EBXA 2CRSA 1V6PA 2L03A 1VB0A 2GOOB 2MFAA 2JQPA 2QC1A 2QJAC 1CB9A 3KFDE 1ERAA 1QM7A 1BXPA 1REWC 3NEQA 4FAOC 1KXIA 2NBTA 2VLWA 1MAHF 1HAAA 2H62D 2HLRA 1KS6A 2QJBC 2CRTA 1JGKA 1LX5B 4XJJA 4P7UA 1M9ZA 1FASA 4LFTA 2PJYC 4IYEA 1LSIA 2BTXA 2PJYB 1RGJA 1ES7B 2X8BB 1CXOA 1IDHA 3LAQU 2UX2A 1HOYA 1H0JA 1I02A 3EBXA 1UG4A 1KU6B 1QKEA 2H7ZA 4RUDA 4UY2C 2H8UA 2H7ZB 1NYUA 1B41B 1CDTA 2MUPA 1L4WA 1ERGA 1XT3A 2UWRA 1IK8A 4EY8B 1LXHA 3HH7A 1ABTA 4ZQYA 3BT1U 4HQPF 5DZ5A 1COEA 2MJ0A 3VTSA 2QJ9C 1CCQA 3U73U 2K3GA 1NTXA 4OM4A 2LCRA 2L5SA 5DO6A 1NYSA 1PLOA 3PLCA 1IJCA 2H64C 1TFSA 2I9BE 1KFHA 1QKDA 2JVEA 1FRAA 1KL8A 1KTZB 1HC9A 2H64B 2MHYA 1JE9A 1HC9B 1IDIA 1NXBA 2BHIA 3ERAA 2FD6U 1RL5A 1G6MA 4BIKB 1CVOA 1LJZA 2CTXA 1CDSA 1DRSA 2ABXA 1KBAA 2GOOC 2LA1A 3FEVA 1TXBA 1FF4A 2J8BA 1NEAA 1IQ9A 1W6BA 2H5FA 2OFSA 3NH7A 1YWHA 1NTNA 1TGXA 2MJYA 1JBDA 1FSSB 2N99A 1KBSA 3EVSC 1NORA 1IKCA 3NDSA 1IDGA 1CDRA 5IMYC 1CHVS 6EBXA 1IDLA 3QB4B 2ERAA 1BTEA 2MUOA 3U74U 1CRFA 1KBTA 4BDTB 3KFDI 4OM5A 1LXGA 1CDQA 1F8UB 5IMTD 1ZADA 1CTXA 1KC4A 1ONJA 2H62C 2CDXA 3BT2U 1S4YA 1CREA 4QTIU 4DO8A 1CODA 1CXNA 1FFJA 1FSCA 1HAJA 2CCXA 5DU1A 1F94A 4AEAA 1TXAA
chains in the Genus database with same CATH superfamily
2HLQA 4FAOE 2MJ4A 1MR6A 5EBXA 2CRSA 1V6PA 2L03A 1VB0A 2GOOB 2MFAA 2JQPA 2QC1A 2QJAC 1CB9A 3KFDE 1ERAA 1QM7A 1BXPA 1REWC 3NEQA 4FAOC 1KXIA 2NBTA 2VLWA 1MAHF 1HAAA 2H62D 2HLRA 1KS6A 2QJBC 2CRTA 1JGKA 1LX5B 4XJJA 4P7UA 1M9ZA 1FASA 4LFTA 2PJYC 4IYEA 1LSIA 2BTXA 2PJYB 1RGJA 1ES7B 2X8BB 1CXOA 1IDHA 3LAQU 2UX2A 4KSNA 1H0JA 1HOYA 1I02A 3EBXA 1UG4A 1KU6B 1QKEA 2H7ZA 4RUDA 4UY2C 2H8UA 2H7ZB 1NYUA 1B41B 1CDTA 2MUPA 1L4WA 1ERGA 1XT3A 2UWRA 1IK8A 4EY8B 1LXHA 3HH7A 1ABTA 4ZQYA 3BT1U 4HQPF 5DZ5A 1COEA 2MJ0A 3VTSA 2QJ9C 1CCQA 3U73U 2K3GA 1NTXA 4OM4A 2LCRA 2L5SA 5DO6A 1NYSA 1PLOA 3PLCA 1IJCA 2H64C 1TFSA 2I9BE 1KFHA 1QKDA 2JVEA 1FRAA 1KL8A 1KTZB 1HC9A 2H64B 2MHYA 1JE9A 1HC9B 1IDIA 1NXBA 2BHIA 3ERAA 2FD6U 1RL5A 1G6MA 4BIKB 1CVOA 1LJZA 2CTXA 1CDSA 1DRSA 2ABXA 1KBAA 2GOOC 2LA1A 3FEVA 1TXBA 1FF4A 2J8BA 1NEAA 1IQ9A 1W6BA 2H5FA 2OFSA 3NH7A 1YWHA 1NTNA 1TGXA 2MJYA 1JBDA 1FSSB 2N99A 1KBSA 3EVSC 1NORA 1IKCA 3NDSA 1IDGA 1CDRA 5IMYC 1CHVS 6EBXA 1IDLA 3QB4B 2ERAA 1BTEA 2MUOA 3U74U 1CRFA 1KBTA 4BDTB 3KFDI 4OM5A 1LXGA 1CDQA 1F8UB 5IMTD 1ZADA 1CTXA 1KC4A 1ONJA 2H62C 2CDXA 3BT2U 1S4YA 1CREA 4QTIU 4DO8A 1CODA 1CXNA 1FFJA 1FSCA 1HAJA 2CCXA 5DU1A 1F94A 4AEAA 1TXAA
chains in the Genus database with same CATH topology
2HLQA 4FAOE 2MJ4A 1MR6A 5EBXA 2CRSA 1V6PA 2L03A 1VB0A 2GOOB 2MFAA 2JQPA 2QC1A 2QJAC 1CB9A 3KFDE 1ERAA 1QM7A 1BXPA 1REWC 3NEQA 4FAOC 1KXIA 2NBTA 2VLWA 1MAHF 1HAAA 2H62D 2HLRA 1KS6A 2QJBC 2CRTA 1JGKA 1LX5B 4XJJA 4P7UA 1M9ZA 1FASA 4LFTA 2PJYC 4IYEA 1LSIA 2BTXA 2PJYB 1RGJA 1ES7B 2X8BB 1CXOA 1IDHA 3LAQU 2UX2A 4KSNA 1H0JA 1HOYA 1I02A 3EBXA 1UG4A 1KU6B 1QKEA 2H7ZA 4RUDA 4UY2C 2H8UA 2H7ZB 1NYUA 1B41B 1CDTA 2MUPA 1L4WA 1ERGA 1XT3A 2UWRA 1IK8A 4EY8B 1LXHA 3HH7A 1ABTA 4ZQYA 3BT1U 4HQPF 5DZ5A 1COEA 2MJ0A 3VTSA 2QJ9C 1CCQA 3U73U 2K3GA 1NTXA 4OM4A 2LCRA 2L5SA 5DO6A 1NYSA 1PLOA 3PLCA 1IJCA 2H64C 1TFSA 2I9BE 1KFHA 1QKDA 2JVEA 1FRAA 1KL8A 1KTZB 1HC9A 2H64B 2MHYA 1JE9A 1HC9B 1IDIA 1NXBA 2BHIA 3ERAA 2FD6U 1RL5A 1G6MA 4BIKB 1CVOA 1LJZA 2CTXA 1CDSA 1DRSA 2ABXA 1KBAA 2GOOC 2LA1A 3FEVA 1TXBA 1FF4A 2J8BA 1NEAA 1IQ9A 1W6BA 2H5FA 2OFSA 3NH7A 1YWHA 1NTNA 1TGXA 2MJYA 1JBDA 1FSSB 2N99A 1KBSA 3EVSC 1NORA 1IKCA 3NDSA 1IDGA 1CDRA 5IMYC 1CHVS 6EBXA 1IDLA 3QB4B 2ERAA 1BTEA 2MUOA 3U74U 1CRFA 1KBTA 4BDTB 3KFDI 4OM5A 1LXGA 1CDQA 1F8UB 5IMTD 1ZADA 1CTXA 1KC4A 1ONJA 2H62C 2CDXA 3BT2U 1S4YA 1CREA 4QTIU 4DO8A 1CODA 1CXNA 1FFJA 1FSCA 1HAJA 2CCXA 5DU1A 1F94A 4AEAA 1TXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HLQ A;  4FAO E;  2MJ4 A;  1MR6 A;  5EBX A;  2CRS A;  1V6P A;  2L03 A;  1VB0 A;  2GOO B;  2MFA A;  2JQP A;  2QC1 A;  2QJA C;  1CB9 A;  3KFD E;  1ERA A;  1QM7 A;  1BXP A;  1REW C;  3NEQ A;  4FAO C;  1KXI A;  2NBT A;  2VLW A;  1MAH F;  1HAA A;  2H62 D;  2HLR A;  1KS6 A;  2QJB C;  2CRT A;  1JGK A;  1LX5 B;  4XJJ A;  4P7U A;  1M9Z A;  1FAS A;  4LFT A;  2PJY C;  4IYE A;  1LSI A;  2BTX A;  2PJY B;  1RGJ A;  1ES7 B;  2X8B B;  1CXO A;  1IDH A;  3LAQ U;  2UX2 A;  1HOY A;  1H0J A;  1I02 A;  3EBX A;  1UG4 A;  1KU6 B;  1QKE A;  2H7Z A;  4RUD A;  4UY2 C;  2H8U A;  2H7Z B;  1NYU A;  1B41 B;  1CDT A;  2MUP A;  1L4W A;  1ERG A;  1XT3 A;  2UWR A;  1IK8 A;  4EY8 B;  1LXH A;  3HH7 A;  1ABT A;  4ZQY A;  3BT1 U;  4HQP F;  5DZ5 A;  1COE A;  2MJ0 A;  3VTS A;  2QJ9 C;  1CCQ A;  3U73 U;  2K3G A;  1NTX A;  4OM4 A;  2LCR A;  2L5S A;  5DO6 A;  1NYS A;  1PLO A;  3PLC A;  1IJC A;  2H64 C;  1TFS A;  2I9B E;  1KFH A;  1QKD A;  2JVE A;  1FRA A;  1KL8 A;  1KTZ B;  1HC9 A;  2H64 B;  2MHY A;  1JE9 A;  1HC9 B;  1IDI A;  1NXB A;  2BHI A;  3ERA A;  2FD6 U;  1RL5 A;  1G6M A;  4BIK B;  1CVO A;  1LJZ A;  2CTX A;  1CDS A;  1DRS A;  2ABX A;  1KBA A;  2GOO C;  2LA1 A;  3FEV A;  1TXB A;  1FF4 A;  2J8B A;  1NEA A;  1IQ9 A;  1W6B A;  2H5F A;  2OFS A;  3NH7 A;  1YWH A;  1NTN A;  1TGX A;  2MJY A;  1JBD A;  1FSS B;  2N99 A;  1KBS A;  3EVS C;  1NOR A;  1IKC A;  3NDS A;  1IDG A;  1CDR A;  5IMY C;  1CHV S;  6EBX A;  1IDL A;  3QB4 B;  2ERA A;  1BTE A;  2MUO A;  3U74 U;  1CRF A;  1KBT A;  4BDT B;  3KFD I;  4OM5 A;  1LXG A;  1CDQ A;  1F8U B;  5IMT D;  1ZAD A;  1CTX A;  1KC4 A;  1ONJ A;  2H62 C;  2CDX A;  3BT2 U;  1S4Y A;  1CRE A;  4QTI U;  4DO8 A;  1COD A;  1CXN A;  1FFJ A;  1FSC A;  1HAJ A;  2CCX A;  5DU1 A;  1F94 A;  4AEA A;  1TXA A; 
#chains in the Genus database with same CATH topology
 2HLQ A;  4FAO E;  2MJ4 A;  1MR6 A;  5EBX A;  2CRS A;  1V6P A;  2L03 A;  1VB0 A;  2GOO B;  2MFA A;  2JQP A;  2QC1 A;  2QJA C;  1CB9 A;  3KFD E;  1ERA A;  1QM7 A;  1BXP A;  1REW C;  3NEQ A;  4FAO C;  1KXI A;  2NBT A;  2VLW A;  1MAH F;  1HAA A;  2H62 D;  2HLR A;  1KS6 A;  2QJB C;  2CRT A;  1JGK A;  1LX5 B;  4XJJ A;  4P7U A;  1M9Z A;  1FAS A;  4LFT A;  2PJY C;  4IYE A;  1LSI A;  2BTX A;  2PJY B;  1RGJ A;  1ES7 B;  2X8B B;  1CXO A;  1IDH A;  3LAQ U;  2UX2 A;  4KSN A;  1H0J A;  1HOY A;  1I02 A;  3EBX A;  1UG4 A;  1KU6 B;  1QKE A;  2H7Z A;  4RUD A;  4UY2 C;  2H8U A;  2H7Z B;  1NYU A;  1B41 B;  1CDT A;  2MUP A;  1L4W A;  1ERG A;  1XT3 A;  2UWR A;  1IK8 A;  4EY8 B;  1LXH A;  3HH7 A;  1ABT A;  4ZQY A;  3BT1 U;  4HQP F;  5DZ5 A;  1COE A;  2MJ0 A;  3VTS A;  2QJ9 C;  1CCQ A;  3U73 U;  2K3G A;  1NTX A;  4OM4 A;  2LCR A;  2L5S A;  5DO6 A;  1NYS A;  1PLO A;  3PLC A;  1IJC A;  2H64 C;  1TFS A;  2I9B E;  1KFH A;  1QKD A;  2JVE A;  1FRA A;  1KL8 A;  1KTZ B;  1HC9 A;  2H64 B;  2MHY A;  1JE9 A;  1HC9 B;  1IDI A;  1NXB A;  2BHI A;  3ERA A;  2FD6 U;  1RL5 A;  1G6M A;  4BIK B;  1CVO A;  1LJZ A;  2CTX A;  1CDS A;  1DRS A;  2ABX A;  1KBA A;  2GOO C;  2LA1 A;  3FEV A;  1TXB A;  1FF4 A;  2J8B A;  1NEA A;  1IQ9 A;  1W6B A;  2H5F A;  2OFS A;  3NH7 A;  1YWH A;  1NTN A;  1TGX A;  2MJY A;  1JBD A;  1FSS B;  2N99 A;  1KBS A;  3EVS C;  1NOR A;  1IKC A;  3NDS A;  1IDG A;  1CDR A;  5IMY C;  1CHV S;  6EBX A;  1IDL A;  3QB4 B;  2ERA A;  1BTE A;  2MUO A;  3U74 U;  1CRF A;  1KBT A;  4BDT B;  3KFD I;  4OM5 A;  1LXG A;  1CDQ A;  1F8U B;  5IMT D;  1ZAD A;  1CTX A;  1KC4 A;  1ONJ A;  2H62 C;  2CDX A;  3BT2 U;  1S4Y A;  1CRE A;  4QTI U;  4DO8 A;  1COD A;  1CXN A;  1FFJ A;  1FSC A;  1HAJ A;  2CCX A;  5DU1 A;  1F94 A;  4AEA A;  1TXA A; 
#chains in the Genus database with same CATH homology
 2HLQ A;  4FAO E;  2MJ4 A;  1MR6 A;  5EBX A;  2CRS A;  1V6P A;  2L03 A;  1VB0 A;  2GOO B;  2MFA A;  2JQP A;  2QC1 A;  2QJA C;  1CB9 A;  3KFD E;  1ERA A;  1QM7 A;  1BXP A;  1REW C;  3NEQ A;  4FAO C;  1KXI A;  2NBT A;  2VLW A;  1MAH F;  1HAA A;  2H62 D;  2HLR A;  1KS6 A;  2QJB C;  2CRT A;  1JGK A;  1LX5 B;  4XJJ A;  4P7U A;  1M9Z A;  1FAS A;  4LFT A;  2PJY C;  4IYE A;  1LSI A;  2BTX A;  2PJY B;  1RGJ A;  1ES7 B;  2X8B B;  1CXO A;  1IDH A;  3LAQ U;  2UX2 A;  4KSN A;  1H0J A;  1HOY A;  1I02 A;  3EBX A;  1UG4 A;  1KU6 B;  1QKE A;  2H7Z A;  4RUD A;  4UY2 C;  2H8U A;  2H7Z B;  1NYU A;  1B41 B;  1CDT A;  2MUP A;  1L4W A;  1ERG A;  1XT3 A;  2UWR A;  1IK8 A;  4EY8 B;  1LXH A;  3HH7 A;  1ABT A;  4ZQY A;  3BT1 U;  4HQP F;  5DZ5 A;  1COE A;  2MJ0 A;  3VTS A;  2QJ9 C;  1CCQ A;  3U73 U;  2K3G A;  1NTX A;  4OM4 A;  2LCR A;  2L5S A;  5DO6 A;  1NYS A;  1PLO A;  3PLC A;  1IJC A;  2H64 C;  1TFS A;  2I9B E;  1KFH A;  1QKD A;  2JVE A;  1FRA A;  1KL8 A;  1KTZ B;  1HC9 A;  2H64 B;  2MHY A;  1JE9 A;  1HC9 B;  1IDI A;  1NXB A;  2BHI A;  3ERA A;  2FD6 U;  1RL5 A;  1G6M A;  4BIK B;  1CVO A;  1LJZ A;  2CTX A;  1CDS A;  1DRS A;  2ABX A;  1KBA A;  2GOO C;  2LA1 A;  3FEV A;  1TXB A;  1FF4 A;  2J8B A;  1NEA A;  1IQ9 A;  1W6B A;  2H5F A;  2OFS A;  3NH7 A;  1YWH A;  1NTN A;  1TGX A;  2MJY A;  1JBD A;  1FSS B;  2N99 A;  1KBS A;  3EVS C;  1NOR A;  1IKC A;  3NDS A;  1IDG A;  1CDR A;  5IMY C;  1CHV S;  6EBX A;  1IDL A;  3QB4 B;  2ERA A;  1BTE A;  2MUO A;  3U74 U;  1CRF A;  1KBT A;  4BDT B;  3KFD I;  4OM5 A;  1LXG A;  1CDQ A;  1F8U B;  5IMT D;  1ZAD A;  1CTX A;  1KC4 A;  1ONJ A;  2H62 C;  2CDX A;  3BT2 U;  1S4Y A;  1CRE A;  4QTI U;  4DO8 A;  1COD A;  1CXN A;  1FFJ A;  1FSC A;  1HAJ A;  2CCX A;  5DU1 A;  1F94 A;  4AEA A;  1TXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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