2X8BB

Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-ii
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/toxin
molecule keywords ACETHYLCHOLINESTERASE
publication title Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.
pubmed doi rcsb
source organism Homo sapiens
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2010-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2x8bB00
2BTXA 1V6PA 4BDTB 1IDIA 1ERAA 1FASA 1MAHF 1TGXA 3KFDI 4OM5A 1JBDA 4BIKB 1LXGA 3HH7A 1KS6A 3VTSA 1F8UB 2ERAA 2J8BA 1QKEA 1COEA 1HAAA 1IKCA 1CDTA 1FFJA 5EBXA 2N99A 2QC1A 1CREA 1CDSA 1QKDA 1I02A 2JVEA 1CXOA 3NH7A 1IDLA 3BT1U 1KXIA 1FSCA 2CRSA 3EBXA 2PJYB 1F94A 1IK8A 4DO8A 1REWC 2MUPA 2MFAA 4ZQYA 1CRFA 1HC9A 1HAJA 2GOOB 1HOYA 1MR6A 2PJYC 1DRSA 1BTEA 1KC4A 1RGJA 2GOOC 4AEAA 1IJCA 1KU6B 1CDRA 4QTIU 4HQPF 1ERGA 2NBTA 1NYSA 2LA1A 2QJBC 1BXPA 2OFSA 3U74U 1KFHA 2MJ0A 2UX2A 5IMTD 2FD6U 1ZADA 2HLQA 1LJZA 2BHIA 2QJ9C 4LFTA 1H0JA 3ERAA 3QB4B 2L03A 2MJ4A 4OM4A 2H7ZA 2CDXA 1ES7B 1CTXA 3FEVA 1NXBA 1LSIA 1NTNA 2HLRA 1NTXA 1TXBA 1W6BA 1IDGA 2H62D 3PLCA 1L4WA 1TXAA 1KBSA 2ABXA 1KL8A 2CRTA 4P7UA 1CVOA 1IDHA 1RL5A 1TFSA 2H5FA 1HC9B 2MUOA 2JQPA 1B41B 3LAQU 3NEQA 1XT3A 4FAOC 4RUDA 1JGKA 1CHVS 1KTZB 4XJJA 3U73U 4IYEA 2L5SA 1IQ9A 3BT2U 6EBXA 5IMYC 1G6MA 1KBTA 3KFDE 1UG4A 2VLWA 2H64B 1LX5B 1FF4A 1CDQA 1FRAA 1FSSB 2LCRA 1ONJA 3NDSA 1YWHA 2MJYA 1JE9A 2H62C 2UWRA 3EVSC 1PLOA 5DU1A 1NYUA 1CODA 2H64C 1NORA 2X8BB 1ABTA 4UY2C 2CTXA 5DO6A 1CXNA 2H7ZB 2CCXA 4EY8B 2H8UA 4FAOE 1QM7A 2MHYA 1KBAA 1VB0A 1M9ZA 1S4YA 2QJAC 1NEAA 2K3GA 1CCQA 5DZ5A 2I9BE 1LXHA 1CB9A
chains in the Genus database with same CATH superfamily
2BTXA 1V6PA 4BDTB 1IDIA 1ERAA 1FASA 1MAHF 1TGXA 3KFDI 4OM5A 1JBDA 4BIKB 1LXGA 3HH7A 1KS6A 3VTSA 1F8UB 2ERAA 2J8BA 1QKEA 1COEA 1HAAA 1IKCA 1CDTA 1FFJA 5EBXA 2N99A 2QC1A 1CREA 1CDSA 1QKDA 1I02A 2JVEA 1CXOA 3NH7A 1IDLA 3BT1U 1KXIA 1FSCA 2CRSA 3EBXA 2PJYB 1F94A 1IK8A 4DO8A 1REWC 2MUPA 2MFAA 4ZQYA 1CRFA 1HC9A 4KSNA 2GOOB 1HAJA 1HOYA 1MR6A 2PJYC 1DRSA 1BTEA 1KC4A 1RGJA 2GOOC 4AEAA 1IJCA 1KU6B 1CDRA 4QTIU 4HQPF 1ERGA 2NBTA 1NYSA 2LA1A 2QJBC 1BXPA 2OFSA 3U74U 1KFHA 2MJ0A 2UX2A 5IMTD 2FD6U 1ZADA 2HLQA 1LJZA 2BHIA 2QJ9C 4LFTA 1H0JA 3ERAA 3QB4B 2L03A 2MJ4A 4OM4A 2H7ZA 2CDXA 1ES7B 1CTXA 3FEVA 1NXBA 1LSIA 1NTNA 2HLRA 1NTXA 1TXBA 1W6BA 1IDGA 2H62D 3PLCA 1L4WA 1TXAA 1KBSA 2ABXA 1KL8A 2CRTA 4P7UA 1CVOA 1IDHA 1RL5A 1TFSA 2H5FA 1HC9B 2MUOA 2JQPA 1B41B 3LAQU 3NEQA 1XT3A 4FAOC 4RUDA 1JGKA 1CHVS 1KTZB 4XJJA 3U73U 4IYEA 2L5SA 1IQ9A 3BT2U 6EBXA 5IMYC 1G6MA 1KBTA 3KFDE 1UG4A 2VLWA 2H64B 1LX5B 1FF4A 1CDQA 1FRAA 1FSSB 2LCRA 1ONJA 3NDSA 1YWHA 2MJYA 1JE9A 2H62C 2UWRA 3EVSC 1PLOA 5DU1A 1NYUA 1CODA 2H64C 1NORA 2X8BB 1ABTA 4UY2C 2CTXA 5DO6A 1CXNA 2H7ZB 2CCXA 4EY8B 2H8UA 4FAOE 1QM7A 2MHYA 1KBAA 1VB0A 1M9ZA 1S4YA 2QJAC 1NEAA 2K3GA 1CCQA 5DZ5A 2I9BE 1LXHA 1CB9A
chains in the Genus database with same CATH topology
2BTXA 1V6PA 4BDTB 1IDIA 1ERAA 1FASA 1MAHF 1TGXA 3KFDI 4OM5A 1JBDA 4BIKB 1LXGA 3HH7A 1KS6A 3VTSA 1F8UB 2ERAA 2J8BA 1QKEA 1COEA 1HAAA 1IKCA 1CDTA 1FFJA 5EBXA 2N99A 2QC1A 1CREA 1CDSA 1QKDA 1I02A 2JVEA 1CXOA 3NH7A 1IDLA 3BT1U 1KXIA 1FSCA 2CRSA 3EBXA 2PJYB 1F94A 1IK8A 4DO8A 1REWC 2MUPA 2MFAA 4ZQYA 1CRFA 1HC9A 4KSNA 2GOOB 1HAJA 1HOYA 1MR6A 2PJYC 1DRSA 1BTEA 1KC4A 1RGJA 2GOOC 4AEAA 1IJCA 1KU6B 1CDRA 4QTIU 4HQPF 1ERGA 2NBTA 1NYSA 2LA1A 2QJBC 1BXPA 2OFSA 3U74U 1KFHA 2MJ0A 2UX2A 5IMTD 2FD6U 1ZADA 2HLQA 1LJZA 2BHIA 2QJ9C 4LFTA 1H0JA 3ERAA 3QB4B 2L03A 2MJ4A 4OM4A 2H7ZA 2CDXA 1ES7B 1CTXA 3FEVA 1NXBA 1LSIA 1NTNA 2HLRA 1NTXA 1TXBA 1W6BA 1IDGA 2H62D 3PLCA 1L4WA 1TXAA 1KBSA 2ABXA 1KL8A 2CRTA 4P7UA 1CVOA 1IDHA 1RL5A 1TFSA 2H5FA 1HC9B 2MUOA 2JQPA 1B41B 3LAQU 3NEQA 1XT3A 4FAOC 4RUDA 1JGKA 1CHVS 1KTZB 4XJJA 3U73U 4IYEA 2L5SA 1IQ9A 3BT2U 6EBXA 5IMYC 1G6MA 1KBTA 3KFDE 1UG4A 2VLWA 2H64B 1LX5B 1FF4A 1CDQA 1FRAA 1FSSB 2LCRA 1ONJA 3NDSA 1YWHA 2MJYA 1JE9A 2H62C 2UWRA 3EVSC 1PLOA 5DU1A 1NYUA 1CODA 2H64C 1NORA 2X8BB 1ABTA 4UY2C 2CTXA 5DO6A 1CXNA 2H7ZB 2CCXA 4EY8B 2H8UA 4FAOE 1QM7A 2MHYA 1KBAA 1VB0A 1M9ZA 1S4YA 2QJAC 1NEAA 2K3GA 1CCQA 5DZ5A 2I9BE 1LXHA 1CB9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BTX A;  1V6P A;  4BDT B;  1IDI A;  1ERA A;  1FAS A;  1MAH F;  1TGX A;  3KFD I;  4OM5 A;  1JBD A;  4BIK B;  1LXG A;  3HH7 A;  1KS6 A;  3VTS A;  1F8U B;  2ERA A;  2J8B A;  1QKE A;  1COE A;  1HAA A;  1IKC A;  1CDT A;  1FFJ A;  5EBX A;  2N99 A;  2QC1 A;  1CRE A;  1CDS A;  1QKD A;  1I02 A;  2JVE A;  1CXO A;  3NH7 A;  1IDL A;  3BT1 U;  1KXI A;  1FSC A;  2CRS A;  3EBX A;  2PJY B;  1F94 A;  1IK8 A;  4DO8 A;  1REW C;  2MUP A;  2MFA A;  4ZQY A;  1CRF A;  1HC9 A;  1HAJ A;  2GOO B;  1HOY A;  1MR6 A;  2PJY C;  1DRS A;  1BTE A;  1KC4 A;  1RGJ A;  2GOO C;  4AEA A;  1IJC A;  1KU6 B;  1CDR A;  4QTI U;  4HQP F;  1ERG A;  2NBT A;  1NYS A;  2LA1 A;  2QJB C;  1BXP A;  2OFS A;  3U74 U;  1KFH A;  2MJ0 A;  2UX2 A;  5IMT D;  2FD6 U;  1ZAD A;  2HLQ A;  1LJZ A;  2BHI A;  2QJ9 C;  4LFT A;  1H0J A;  3ERA A;  3QB4 B;  2L03 A;  2MJ4 A;  4OM4 A;  2H7Z A;  2CDX A;  1ES7 B;  1CTX A;  3FEV A;  1NXB A;  1LSI A;  1NTN A;  2HLR A;  1NTX A;  1TXB A;  1W6B A;  1IDG A;  2H62 D;  3PLC A;  1L4W A;  1TXA A;  1KBS A;  2ABX A;  1KL8 A;  2CRT A;  4P7U A;  1CVO A;  1IDH A;  1RL5 A;  1TFS A;  2H5F A;  1HC9 B;  2MUO A;  2JQP A;  1B41 B;  3LAQ U;  3NEQ A;  1XT3 A;  4FAO C;  4RUD A;  1JGK A;  1CHV S;  1KTZ B;  4XJJ A;  3U73 U;  4IYE A;  2L5S A;  1IQ9 A;  3BT2 U;  6EBX A;  5IMY C;  1G6M A;  1KBT A;  3KFD E;  1UG4 A;  2VLW A;  2H64 B;  1LX5 B;  1FF4 A;  1CDQ A;  1FRA A;  1FSS B;  2LCR A;  1ONJ A;  3NDS A;  1YWH A;  2MJY A;  1JE9 A;  2H62 C;  2UWR A;  3EVS C;  1PLO A;  5DU1 A;  1NYU A;  1COD A;  2H64 C;  1NOR A;  2X8B B;  1ABT A;  4UY2 C;  2CTX A;  5DO6 A;  1CXN A;  2H7Z B;  2CCX A;  4EY8 B;  2H8U A;  4FAO E;  1QM7 A;  2MHY A;  1KBA A;  1VB0 A;  1M9Z A;  1S4Y A;  2QJA C;  1NEA A;  2K3G A;  1CCQ A;  5DZ5 A;  2I9B E;  1LXH A;  1CB9 A; 
#chains in the Genus database with same CATH topology
 2BTX A;  1V6P A;  4BDT B;  1IDI A;  1ERA A;  1FAS A;  1MAH F;  1TGX A;  3KFD I;  4OM5 A;  1JBD A;  4BIK B;  1LXG A;  3HH7 A;  1KS6 A;  3VTS A;  1F8U B;  2ERA A;  2J8B A;  1QKE A;  1COE A;  1HAA A;  1IKC A;  1CDT A;  1FFJ A;  5EBX A;  2N99 A;  2QC1 A;  1CRE A;  1CDS A;  1QKD A;  1I02 A;  2JVE A;  1CXO A;  3NH7 A;  1IDL A;  3BT1 U;  1KXI A;  1FSC A;  2CRS A;  3EBX A;  2PJY B;  1F94 A;  1IK8 A;  4DO8 A;  1REW C;  2MUP A;  2MFA A;  4ZQY A;  1CRF A;  1HC9 A;  4KSN A;  2GOO B;  1HAJ A;  1HOY A;  1MR6 A;  2PJY C;  1DRS A;  1BTE A;  1KC4 A;  1RGJ A;  2GOO C;  4AEA A;  1IJC A;  1KU6 B;  1CDR A;  4QTI U;  4HQP F;  1ERG A;  2NBT A;  1NYS A;  2LA1 A;  2QJB C;  1BXP A;  2OFS A;  3U74 U;  1KFH A;  2MJ0 A;  2UX2 A;  5IMT D;  2FD6 U;  1ZAD A;  2HLQ A;  1LJZ A;  2BHI A;  2QJ9 C;  4LFT A;  1H0J A;  3ERA A;  3QB4 B;  2L03 A;  2MJ4 A;  4OM4 A;  2H7Z A;  2CDX A;  1ES7 B;  1CTX A;  3FEV A;  1NXB A;  1LSI A;  1NTN A;  2HLR A;  1NTX A;  1TXB A;  1W6B A;  1IDG A;  2H62 D;  3PLC A;  1L4W A;  1TXA A;  1KBS A;  2ABX A;  1KL8 A;  2CRT A;  4P7U A;  1CVO A;  1IDH A;  1RL5 A;  1TFS A;  2H5F A;  1HC9 B;  2MUO A;  2JQP A;  1B41 B;  3LAQ U;  3NEQ A;  1XT3 A;  4FAO C;  4RUD A;  1JGK A;  1CHV S;  1KTZ B;  4XJJ A;  3U73 U;  4IYE A;  2L5S A;  1IQ9 A;  3BT2 U;  6EBX A;  5IMY C;  1G6M A;  1KBT A;  3KFD E;  1UG4 A;  2VLW A;  2H64 B;  1LX5 B;  1FF4 A;  1CDQ A;  1FRA A;  1FSS B;  2LCR A;  1ONJ A;  3NDS A;  1YWH A;  2MJY A;  1JE9 A;  2H62 C;  2UWR A;  3EVS C;  1PLO A;  5DU1 A;  1NYU A;  1COD A;  2H64 C;  1NOR A;  2X8B B;  1ABT A;  4UY2 C;  2CTX A;  5DO6 A;  1CXN A;  2H7Z B;  2CCX A;  4EY8 B;  2H8U A;  4FAO E;  1QM7 A;  2MHY A;  1KBA A;  1VB0 A;  1M9Z A;  1S4Y A;  2QJA C;  1NEA A;  2K3G A;  1CCQ A;  5DZ5 A;  2I9B E;  1LXH A;  1CB9 A; 
#chains in the Genus database with same CATH homology
 2BTX A;  1V6P A;  4BDT B;  1IDI A;  1ERA A;  1FAS A;  1MAH F;  1TGX A;  3KFD I;  4OM5 A;  1JBD A;  4BIK B;  1LXG A;  3HH7 A;  1KS6 A;  3VTS A;  1F8U B;  2ERA A;  2J8B A;  1QKE A;  1COE A;  1HAA A;  1IKC A;  1CDT A;  1FFJ A;  5EBX A;  2N99 A;  2QC1 A;  1CRE A;  1CDS A;  1QKD A;  1I02 A;  2JVE A;  1CXO A;  3NH7 A;  1IDL A;  3BT1 U;  1KXI A;  1FSC A;  2CRS A;  3EBX A;  2PJY B;  1F94 A;  1IK8 A;  4DO8 A;  1REW C;  2MUP A;  2MFA A;  4ZQY A;  1CRF A;  1HC9 A;  4KSN A;  2GOO B;  1HAJ A;  1HOY A;  1MR6 A;  2PJY C;  1DRS A;  1BTE A;  1KC4 A;  1RGJ A;  2GOO C;  4AEA A;  1IJC A;  1KU6 B;  1CDR A;  4QTI U;  4HQP F;  1ERG A;  2NBT A;  1NYS A;  2LA1 A;  2QJB C;  1BXP A;  2OFS A;  3U74 U;  1KFH A;  2MJ0 A;  2UX2 A;  5IMT D;  2FD6 U;  1ZAD A;  2HLQ A;  1LJZ A;  2BHI A;  2QJ9 C;  4LFT A;  1H0J A;  3ERA A;  3QB4 B;  2L03 A;  2MJ4 A;  4OM4 A;  2H7Z A;  2CDX A;  1ES7 B;  1CTX A;  3FEV A;  1NXB A;  1LSI A;  1NTN A;  2HLR A;  1NTX A;  1TXB A;  1W6B A;  1IDG A;  2H62 D;  3PLC A;  1L4W A;  1TXA A;  1KBS A;  2ABX A;  1KL8 A;  2CRT A;  4P7U A;  1CVO A;  1IDH A;  1RL5 A;  1TFS A;  2H5F A;  1HC9 B;  2MUO A;  2JQP A;  1B41 B;  3LAQ U;  3NEQ A;  1XT3 A;  4FAO C;  4RUD A;  1JGK A;  1CHV S;  1KTZ B;  4XJJ A;  3U73 U;  4IYE A;  2L5S A;  1IQ9 A;  3BT2 U;  6EBX A;  5IMY C;  1G6M A;  1KBT A;  3KFD E;  1UG4 A;  2VLW A;  2H64 B;  1LX5 B;  1FF4 A;  1CDQ A;  1FRA A;  1FSS B;  2LCR A;  1ONJ A;  3NDS A;  1YWH A;  2MJY A;  1JE9 A;  2H62 C;  2UWR A;  3EVS C;  1PLO A;  5DU1 A;  1NYU A;  1COD A;  2H64 C;  1NOR A;  2X8B B;  1ABT A;  4UY2 C;  2CTX A;  5DO6 A;  1CXN A;  2H7Z B;  2CCX A;  4EY8 B;  2H8U A;  4FAO E;  1QM7 A;  2MHY A;  1KBA A;  1VB0 A;  1M9Z A;  1S4Y A;  2QJA C;  1NEA A;  2K3G A;  1CCQ A;  5DZ5 A;  2I9B E;  1LXH A;  1CB9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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