2X8BB

Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-ii
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
61
structure length
61
Chain Sequence
TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.
pubmed doi rcsb
molecule tags Hydrolase/toxin
source organism Homo sapiens
molecule keywords ACETHYLCHOLINESTERASE
total genus 10
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2010-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2x8bB00
1FSSB 1CRFA 1JBDA 2PJYC 1LSIA 4FAOE 1MAHF 1IK8A 4BIKB 4DO8A 6EBXA 1ERGA 3EVSC 4BDTB 1NXBA 2MFAA 2UX2A 1NTNA 4ZQYA 3QB4B 1CDRA 2H7ZA 3PLCA 1HC9B 1CHVS 1UG4A 1RL5A 1H0JA 1TXBA 4IYEA 1ZADA 1CVOA 1QKEA 1NYSA 1VB0A 2MJ0A 2H7ZB 1ONJA 3NH7A 2OFSA 4XJJA 1KBTA 1CXOA 1KL8A 4P7UA 3EBXA 1IJCA 1FF4A 1TGXA 2H8UA 1S4YA 1G6MA 2FD6U 2BTXA 1IDGA 4UY2C 4OM5A 2QJAC 5IMTD 1IDLA 3NDSA 1NEAA 1L4WA 2ABXA 1KXIA 2HLRA 2LA1A 3BT2U 1W6BA 1CODA 3VTSA 3ERAA 1I02A 1BXPA 1PLOA 2CTXA 1CTXA 2MHYA 1F8UB 1KTZB 2MJYA 2CDXA 2JQPA 2JVEA 1MR6A 1RGJA 2H64C 2L03A 2QJ9C 4RUDA 2J8BA 1XT3A 2NBTA 1TFSA 1HAJA 1REWC 2I9BE 1CDQA 1CCQA 1CXNA 2CRTA 2QJBC 1DRSA 1KU6B 1IKCA 1NYUA 2PJYB 1KFHA 1CB9A 2CRSA 3KFDE 1KS6A 2H62D 4EY8B 1HOYA 1CDTA 2K3GA 2QC1A 1IDIA 1LXGA 4OM4A 5EBXA 3HH7A 1KBAA 1FRAA 5DZ5A 1ES7B 3KFDI 2GOOB 4LFTA 1IDHA 1FFJA 2BHIA 2MUOA 5DU1A 1HAAA 3FEVA 1KC4A 1IQ9A 1FASA 1QKDA 1BTEA 2H5FA 1LXHA 2X8BB 1HC9A 1NTXA 2MUPA 1M9ZA 1QM7A 2VLWA 1ABTA 1ERAA 1YWHA 2LCRA 3U74U 2L5SA 1V6PA 2ERAA 2GOOC 1KBSA 1F94A 3BT1U 2HLQA 4AEAA 1JE9A 4HQPF 5DO6A 1TXAA 4FAOC 1B41B 4QTIU 2H62C 2N99A 3U73U 2CCXA 3NEQA 1LX5B 1COEA 2H64B 1NORA 1CREA 2MJ4A 2UWRA 1CDSA 5IMYC 1LJZA 1FSCA 3LAQU 1JGKA
chains in the Genus database with same CATH superfamily
1FSSB 1CRFA 1JBDA 2PJYC 1LSIA 4FAOE 1MAHF 1IK8A 4BIKB 4DO8A 6EBXA 1ERGA 3EVSC 4BDTB 1NXBA 2MFAA 2UX2A 1NTNA 4ZQYA 3QB4B 1CDRA 2H7ZA 3PLCA 1HC9B 1CHVS 1UG4A 1RL5A 1H0JA 1TXBA 4IYEA 1ZADA 1CVOA 1QKEA 1NYSA 1VB0A 2MJ0A 2H7ZB 1ONJA 3NH7A 2OFSA 4XJJA 1KBTA 1CXOA 1KL8A 4P7UA 3EBXA 1IJCA 1FF4A 1TGXA 2H8UA 1S4YA 1G6MA 2FD6U 2BTXA 1IDGA 4UY2C 4OM5A 2QJAC 5IMTD 1IDLA 3NDSA 1NEAA 1L4WA 2ABXA 1KXIA 2HLRA 2LA1A 3BT2U 1W6BA 1CODA 3VTSA 3ERAA 1I02A 1BXPA 1PLOA 2CTXA 1CTXA 2MHYA 1F8UB 1KTZB 2MJYA 2CDXA 2JQPA 2JVEA 1MR6A 1RGJA 2H64C 2L03A 2QJ9C 4RUDA 2J8BA 1XT3A 2NBTA 1TFSA 1HAJA 1REWC 2I9BE 1CDQA 1CCQA 1CXNA 2CRTA 2QJBC 1DRSA 1KU6B 1IKCA 1NYUA 2PJYB 1KFHA 1CB9A 2CRSA 3KFDE 1KS6A 2H62D 4EY8B 1HOYA 1CDTA 2K3GA 2QC1A 1IDIA 1LXGA 4OM4A 5EBXA 3HH7A 1KBAA 1FRAA 5DZ5A 1ES7B 3KFDI 2GOOB 4LFTA 1IDHA 1FFJA 2BHIA 2MUOA 5DU1A 1HAAA 3FEVA 1KC4A 1IQ9A 1FASA 1QKDA 1BTEA 2H5FA 1LXHA 2X8BB 1HC9A 1NTXA 2MUPA 1M9ZA 1QM7A 2VLWA 1ABTA 1ERAA 4KSNA 1YWHA 2LCRA 3U74U 2L5SA 1V6PA 2ERAA 2GOOC 1KBSA 1F94A 3BT1U 2HLQA 4AEAA 1JE9A 4HQPF 5DO6A 1TXAA 4FAOC 1B41B 4QTIU 2H62C 2N99A 3U73U 2CCXA 3NEQA 1LX5B 1COEA 2H64B 1NORA 1CREA 2MJ4A 2UWRA 1CDSA 5IMYC 1LJZA 1FSCA 3LAQU 1JGKA
chains in the Genus database with same CATH topology
1FSSB 1CRFA 1JBDA 2PJYC 1LSIA 4FAOE 1MAHF 1IK8A 4BIKB 4DO8A 6EBXA 1ERGA 3EVSC 4BDTB 1NXBA 2MFAA 2UX2A 1NTNA 4ZQYA 3QB4B 1CDRA 2H7ZA 3PLCA 1HC9B 1CHVS 1UG4A 1RL5A 1H0JA 1TXBA 4IYEA 1ZADA 1CVOA 1QKEA 1NYSA 1VB0A 2MJ0A 2H7ZB 1ONJA 3NH7A 2OFSA 4XJJA 1KBTA 1CXOA 1KL8A 4P7UA 3EBXA 1IJCA 1FF4A 1TGXA 2H8UA 1S4YA 1G6MA 2FD6U 2BTXA 1IDGA 4UY2C 4OM5A 2QJAC 5IMTD 1IDLA 3NDSA 1NEAA 1L4WA 2ABXA 1KXIA 2HLRA 2LA1A 3BT2U 1W6BA 1CODA 3VTSA 3ERAA 1I02A 1BXPA 1PLOA 2CTXA 1CTXA 2MHYA 1F8UB 1KTZB 2MJYA 2CDXA 2JQPA 2JVEA 1MR6A 1RGJA 2H64C 2L03A 2QJ9C 4RUDA 2J8BA 1XT3A 2NBTA 1TFSA 1HAJA 1REWC 2I9BE 1CDQA 1CCQA 1CXNA 2CRTA 2QJBC 1DRSA 1KU6B 1IKCA 1NYUA 2PJYB 1KFHA 1CB9A 2CRSA 3KFDE 1KS6A 2H62D 4EY8B 1HOYA 1CDTA 2K3GA 2QC1A 1IDIA 1LXGA 4OM4A 5EBXA 3HH7A 1KBAA 1FRAA 5DZ5A 1ES7B 3KFDI 2GOOB 4LFTA 1IDHA 1FFJA 2BHIA 2MUOA 5DU1A 1HAAA 3FEVA 1KC4A 1IQ9A 1FASA 1QKDA 1BTEA 2H5FA 1LXHA 2X8BB 1HC9A 1NTXA 2MUPA 1M9ZA 1QM7A 2VLWA 1ABTA 1ERAA 4KSNA 1YWHA 2LCRA 3U74U 2L5SA 1V6PA 2ERAA 2GOOC 1KBSA 1F94A 3BT1U 2HLQA 4AEAA 1JE9A 4HQPF 5DO6A 1TXAA 4FAOC 1B41B 4QTIU 2H62C 2N99A 3U73U 2CCXA 3NEQA 1LX5B 1COEA 2H64B 1NORA 1CREA 2MJ4A 2UWRA 1CDSA 5IMYC 1LJZA 1FSCA 3LAQU 1JGKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FSS B;  1CRF A;  1JBD A;  2PJY C;  1LSI A;  4FAO E;  1MAH F;  1IK8 A;  4BIK B;  4DO8 A;  6EBX A;  1ERG A;  3EVS C;  4BDT B;  1NXB A;  2MFA A;  2UX2 A;  1NTN A;  4ZQY A;  3QB4 B;  1CDR A;  2H7Z A;  3PLC A;  1HC9 B;  1CHV S;  1UG4 A;  1RL5 A;  1H0J A;  1TXB A;  4IYE A;  1ZAD A;  1CVO A;  1QKE A;  1NYS A;  1VB0 A;  2MJ0 A;  2H7Z B;  1ONJ A;  3NH7 A;  2OFS A;  4XJJ A;  1KBT A;  1CXO A;  1KL8 A;  4P7U A;  3EBX A;  1IJC A;  1FF4 A;  1TGX A;  2H8U A;  1S4Y A;  1G6M A;  2FD6 U;  2BTX A;  1IDG A;  4UY2 C;  4OM5 A;  2QJA C;  5IMT D;  1IDL A;  3NDS A;  1NEA A;  1L4W A;  2ABX A;  1KXI A;  2HLR A;  2LA1 A;  3BT2 U;  1W6B A;  1COD A;  3VTS A;  3ERA A;  1I02 A;  1BXP A;  1PLO A;  2CTX A;  1CTX A;  2MHY A;  1F8U B;  1KTZ B;  2MJY A;  2CDX A;  2JQP A;  2JVE A;  1MR6 A;  1RGJ A;  2H64 C;  2L03 A;  2QJ9 C;  4RUD A;  2J8B A;  1XT3 A;  2NBT A;  1TFS A;  1HAJ A;  1REW C;  2I9B E;  1CDQ A;  1CCQ A;  1CXN A;  2CRT A;  2QJB C;  1DRS A;  1KU6 B;  1IKC A;  1NYU A;  2PJY B;  1KFH A;  1CB9 A;  2CRS A;  3KFD E;  1KS6 A;  2H62 D;  4EY8 B;  1HOY A;  1CDT A;  2K3G A;  2QC1 A;  1IDI A;  1LXG A;  4OM4 A;  5EBX A;  3HH7 A;  1KBA A;  1FRA A;  5DZ5 A;  1ES7 B;  3KFD I;  2GOO B;  4LFT A;  1IDH A;  1FFJ A;  2BHI A;  2MUO A;  5DU1 A;  1HAA A;  3FEV A;  1KC4 A;  1IQ9 A;  1FAS A;  1QKD A;  1BTE A;  2H5F A;  1LXH A;  2X8B B;  1HC9 A;  1NTX A;  2MUP A;  1M9Z A;  1QM7 A;  2VLW A;  1ABT A;  1ERA A;  1YWH A;  2LCR A;  3U74 U;  2L5S A;  1V6P A;  2ERA A;  2GOO C;  1KBS A;  1F94 A;  3BT1 U;  2HLQ A;  4AEA A;  1JE9 A;  4HQP F;  5DO6 A;  1TXA A;  4FAO C;  1B41 B;  4QTI U;  2H62 C;  2N99 A;  3U73 U;  2CCX A;  3NEQ A;  1LX5 B;  1COE A;  2H64 B;  1NOR A;  1CRE A;  2MJ4 A;  2UWR A;  1CDS A;  5IMY C;  1LJZ A;  1FSC A;  3LAQ U;  1JGK A; 
#chains in the Genus database with same CATH topology
 1FSS B;  1CRF A;  1JBD A;  2PJY C;  1LSI A;  4FAO E;  1MAH F;  1IK8 A;  4BIK B;  4DO8 A;  6EBX A;  1ERG A;  3EVS C;  4BDT B;  1NXB A;  2MFA A;  2UX2 A;  1NTN A;  4ZQY A;  3QB4 B;  1CDR A;  2H7Z A;  3PLC A;  1HC9 B;  1CHV S;  1UG4 A;  1RL5 A;  1H0J A;  1TXB A;  4IYE A;  1ZAD A;  1CVO A;  1QKE A;  1NYS A;  1VB0 A;  2MJ0 A;  2H7Z B;  1ONJ A;  3NH7 A;  2OFS A;  4XJJ A;  1KBT A;  1CXO A;  1KL8 A;  4P7U A;  3EBX A;  1IJC A;  1FF4 A;  1TGX A;  2H8U A;  1S4Y A;  1G6M A;  2FD6 U;  2BTX A;  1IDG A;  4UY2 C;  4OM5 A;  2QJA C;  5IMT D;  1IDL A;  3NDS A;  1NEA A;  1L4W A;  2ABX A;  1KXI A;  2HLR A;  2LA1 A;  3BT2 U;  1W6B A;  1COD A;  3VTS A;  3ERA A;  1I02 A;  1BXP A;  1PLO A;  2CTX A;  1CTX A;  2MHY A;  1F8U B;  1KTZ B;  2MJY A;  2CDX A;  2JQP A;  2JVE A;  1MR6 A;  1RGJ A;  2H64 C;  2L03 A;  2QJ9 C;  4RUD A;  2J8B A;  1XT3 A;  2NBT A;  1TFS A;  1HAJ A;  1REW C;  2I9B E;  1CDQ A;  1CCQ A;  1CXN A;  2CRT A;  2QJB C;  1DRS A;  1KU6 B;  1IKC A;  1NYU A;  2PJY B;  1KFH A;  1CB9 A;  2CRS A;  3KFD E;  1KS6 A;  2H62 D;  4EY8 B;  1HOY A;  1CDT A;  2K3G A;  2QC1 A;  1IDI A;  1LXG A;  4OM4 A;  5EBX A;  3HH7 A;  1KBA A;  1FRA A;  5DZ5 A;  1ES7 B;  3KFD I;  2GOO B;  4LFT A;  1IDH A;  1FFJ A;  2BHI A;  2MUO A;  5DU1 A;  1HAA A;  3FEV A;  1KC4 A;  1IQ9 A;  1FAS A;  1QKD A;  1BTE A;  2H5F A;  1LXH A;  2X8B B;  1HC9 A;  1NTX A;  2MUP A;  1M9Z A;  1QM7 A;  2VLW A;  1ABT A;  1ERA A;  4KSN A;  1YWH A;  2LCR A;  3U74 U;  2L5S A;  1V6P A;  2ERA A;  2GOO C;  1KBS A;  1F94 A;  3BT1 U;  2HLQ A;  4AEA A;  1JE9 A;  4HQP F;  5DO6 A;  1TXA A;  4FAO C;  1B41 B;  4QTI U;  2H62 C;  2N99 A;  3U73 U;  2CCX A;  3NEQ A;  1LX5 B;  1COE A;  2H64 B;  1NOR A;  1CRE A;  2MJ4 A;  2UWR A;  1CDS A;  5IMY C;  1LJZ A;  1FSC A;  3LAQ U;  1JGK A; 
#chains in the Genus database with same CATH homology
 1FSS B;  1CRF A;  1JBD A;  2PJY C;  1LSI A;  4FAO E;  1MAH F;  1IK8 A;  4BIK B;  4DO8 A;  6EBX A;  1ERG A;  3EVS C;  4BDT B;  1NXB A;  2MFA A;  2UX2 A;  1NTN A;  4ZQY A;  3QB4 B;  1CDR A;  2H7Z A;  3PLC A;  1HC9 B;  1CHV S;  1UG4 A;  1RL5 A;  1H0J A;  1TXB A;  4IYE A;  1ZAD A;  1CVO A;  1QKE A;  1NYS A;  1VB0 A;  2MJ0 A;  2H7Z B;  1ONJ A;  3NH7 A;  2OFS A;  4XJJ A;  1KBT A;  1CXO A;  1KL8 A;  4P7U A;  3EBX A;  1IJC A;  1FF4 A;  1TGX A;  2H8U A;  1S4Y A;  1G6M A;  2FD6 U;  2BTX A;  1IDG A;  4UY2 C;  4OM5 A;  2QJA C;  5IMT D;  1IDL A;  3NDS A;  1NEA A;  1L4W A;  2ABX A;  1KXI A;  2HLR A;  2LA1 A;  3BT2 U;  1W6B A;  1COD A;  3VTS A;  3ERA A;  1I02 A;  1BXP A;  1PLO A;  2CTX A;  1CTX A;  2MHY A;  1F8U B;  1KTZ B;  2MJY A;  2CDX A;  2JQP A;  2JVE A;  1MR6 A;  1RGJ A;  2H64 C;  2L03 A;  2QJ9 C;  4RUD A;  2J8B A;  1XT3 A;  2NBT A;  1TFS A;  1HAJ A;  1REW C;  2I9B E;  1CDQ A;  1CCQ A;  1CXN A;  2CRT A;  2QJB C;  1DRS A;  1KU6 B;  1IKC A;  1NYU A;  2PJY B;  1KFH A;  1CB9 A;  2CRS A;  3KFD E;  1KS6 A;  2H62 D;  4EY8 B;  1HOY A;  1CDT A;  2K3G A;  2QC1 A;  1IDI A;  1LXG A;  4OM4 A;  5EBX A;  3HH7 A;  1KBA A;  1FRA A;  5DZ5 A;  1ES7 B;  3KFD I;  2GOO B;  4LFT A;  1IDH A;  1FFJ A;  2BHI A;  2MUO A;  5DU1 A;  1HAA A;  3FEV A;  1KC4 A;  1IQ9 A;  1FAS A;  1QKD A;  1BTE A;  2H5F A;  1LXH A;  2X8B B;  1HC9 A;  1NTX A;  2MUP A;  1M9Z A;  1QM7 A;  2VLW A;  1ABT A;  1ERA A;  4KSN A;  1YWH A;  2LCR A;  3U74 U;  2L5S A;  1V6P A;  2ERA A;  2GOO C;  1KBS A;  1F94 A;  3BT1 U;  2HLQ A;  4AEA A;  1JE9 A;  4HQP F;  5DO6 A;  1TXA A;  4FAO C;  1B41 B;  4QTI U;  2H62 C;  2N99 A;  3U73 U;  2CCX A;  3NEQ A;  1LX5 B;  1COE A;  2H64 B;  1NOR A;  1CRE A;  2MJ4 A;  2UWR A;  1CDS A;  5IMY C;  1LJZ A;  1FSC A;  3LAQ U;  1JGK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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