1S4YA

Crystal structure of the activin/actriib extracellular domain
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
91
structure length
91
Chain Sequence
RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors.
pubmed doi rcsb
molecule tags Transferase
source organism Mus musculus
molecule keywords Activin receptor type IIB precursor
total genus 22
structure length 91
sequence length 91
chains with identical sequence C
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2004-01-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 1s4yA00
4OM4A 4AEAA 1CXNA 1KXIA 1KBTA 1B41B 1IDGA 1NTNA 2PJYC 1KC4A 1F94A 3NEQA 2MJYA 1JGKA 1ONJA 2GOOB 1LXHA 2H8UA 1CDRA 1HC9A 2H64B 2UWRA 1QKEA 3FEVA 1IDLA 1REWC 1G6MA 1I02A 2ERAA 1CTXA 1TFSA 2I9BE 2QC1A 2MJ0A 2N99A 2VLWA 1CRFA 1FRAA 4OM5A 2JQPA 4BIKB 2QJAC 2NBTA 4LFTA 4RUDA 1KFHA 1M9ZA 2H7ZA 2K3GA 1CDSA 2H62D 1TGXA 2CRSA 1COEA 4FAOC 2CRTA 3QB4B 2L03A 2X8BB 1NEAA 1UG4A 1FFJA 2CCXA 1HAJA 2OFSA 1TXAA 3HH7A 4DO8A 1IK8A 1IDIA 1BXPA 1PLOA 2H62C 4P7UA 2GOOC 1ERGA 3U74U 4EY8B 1V6PA 1ERAA 2H64C 2MHYA 2CDXA 2LCRA 1NYUA 1NYSA 1QKDA 1FASA 1HOYA 2L5SA 1XT3A 2ABXA 5DU1A 4HQPF 2HLRA 1JE9A 4QTIU 2HLQA 5IMTD 1CCQA 1CVOA 3PLCA 3NDSA 3BT1U 1FSCA 3EVSC 1H0JA 4BDTB 1JBDA 3KFDE 1L4WA 2CTXA 1LSIA 5DO6A 2J8BA 2BHIA 1TXBA 1MR6A 5DZ5A 1ZADA 1CODA 2FD6U 1FF4A 1FSSB 1MAHF 2BTXA 3VTSA 2MJ4A 5EBXA 1KBSA 1BTEA 1KU6B 2UX2A 1HC9B 3ERAA 1CREA 4XJJA 1IJCA 1ABTA 4IYEA 2QJ9C 2H5FA 1KBAA 1HAAA 3BT2U 1DRSA 1CDTA 2PJYB 1S4YA 2JVEA 4FAOE 6EBXA 2QJBC 3KFDI 2H7ZB 4UY2C 1RGJA 1VB0A 1CXOA 2MFAA 2MUPA 1F8UB 1KTZB 4ZQYA 5IMYC 1NTXA 1QM7A 1W6BA 1LJZA 1IKCA 1YWHA 1KS6A 2LA1A 1IDHA 1CDQA 1CB9A 1LXGA 1CHVS 1KL8A 1NORA 1RL5A 1ES7B 1IQ9A 3EBXA 3NH7A 1NXBA 1LX5B 3U73U 2MUOA 3LAQU
chains in the Genus database with same CATH superfamily
4OM4A 4AEAA 1CXNA 1KXIA 1KBTA 1B41B 1IDGA 1NTNA 2PJYC 1KC4A 1F94A 3NEQA 2MJYA 1JGKA 1ONJA 2GOOB 1LXHA 2H8UA 1CDRA 1HC9A 2H64B 2UWRA 1QKEA 3FEVA 1IDLA 1REWC 1G6MA 1I02A 4KSNA 2ERAA 1CTXA 1TFSA 2I9BE 2QC1A 2MJ0A 2N99A 2VLWA 1CRFA 1FRAA 4OM5A 2JQPA 4BIKB 2QJAC 2NBTA 4LFTA 4RUDA 1KFHA 1M9ZA 2H7ZA 2K3GA 1CDSA 2H62D 1TGXA 2CRSA 1COEA 4FAOC 2CRTA 3QB4B 2L03A 2X8BB 1NEAA 1UG4A 1FFJA 2CCXA 1HAJA 2OFSA 1TXAA 3HH7A 4DO8A 1IK8A 1IDIA 1BXPA 1PLOA 2H62C 4P7UA 2GOOC 1ERGA 3U74U 4EY8B 1V6PA 1ERAA 2H64C 2MHYA 2CDXA 2LCRA 1NYUA 1NYSA 1QKDA 1FASA 1HOYA 2L5SA 1XT3A 2ABXA 5DU1A 4HQPF 2HLRA 1JE9A 4QTIU 2HLQA 5IMTD 1CCQA 1CVOA 3PLCA 3NDSA 3BT1U 1FSCA 3EVSC 1H0JA 4BDTB 1JBDA 3KFDE 1L4WA 2CTXA 1LSIA 5DO6A 2J8BA 2BHIA 1TXBA 1MR6A 5DZ5A 1ZADA 1CODA 2FD6U 1FF4A 1FSSB 1MAHF 2BTXA 3VTSA 2MJ4A 5EBXA 1KBSA 1BTEA 1KU6B 2UX2A 1HC9B 3ERAA 1CREA 4XJJA 1IJCA 1ABTA 4IYEA 2QJ9C 2H5FA 1KBAA 1HAAA 3BT2U 1DRSA 1CDTA 2PJYB 1S4YA 2JVEA 4FAOE 6EBXA 2QJBC 3KFDI 2H7ZB 4UY2C 1RGJA 1VB0A 1CXOA 2MFAA 2MUPA 1F8UB 1KTZB 4ZQYA 5IMYC 1NTXA 1QM7A 1W6BA 1LJZA 1IKCA 1YWHA 1KS6A 2LA1A 1IDHA 1CDQA 1CB9A 1LXGA 1CHVS 1KL8A 1NORA 1RL5A 1ES7B 1IQ9A 3EBXA 3NH7A 1NXBA 1LX5B 3U73U 2MUOA 3LAQU
chains in the Genus database with same CATH topology
4OM4A 4AEAA 1CXNA 1KXIA 1KBTA 1B41B 1IDGA 1NTNA 2PJYC 1KC4A 1F94A 3NEQA 2MJYA 1JGKA 1ONJA 2GOOB 1LXHA 2H8UA 1CDRA 1HC9A 2H64B 2UWRA 1QKEA 3FEVA 1IDLA 1REWC 1G6MA 1I02A 4KSNA 2ERAA 1CTXA 1TFSA 2I9BE 2QC1A 2MJ0A 2N99A 2VLWA 1CRFA 1FRAA 4OM5A 2JQPA 4BIKB 2QJAC 2NBTA 4LFTA 4RUDA 1KFHA 1M9ZA 2H7ZA 2K3GA 1CDSA 2H62D 1TGXA 2CRSA 1COEA 4FAOC 2CRTA 3QB4B 2L03A 2X8BB 1NEAA 1UG4A 1FFJA 2CCXA 1HAJA 2OFSA 1TXAA 3HH7A 4DO8A 1IK8A 1IDIA 1BXPA 1PLOA 2H62C 4P7UA 2GOOC 1ERGA 3U74U 4EY8B 1V6PA 1ERAA 2H64C 2MHYA 2CDXA 2LCRA 1NYUA 1NYSA 1QKDA 1FASA 1HOYA 2L5SA 1XT3A 2ABXA 5DU1A 4HQPF 2HLRA 1JE9A 4QTIU 2HLQA 5IMTD 1CCQA 1CVOA 3PLCA 3NDSA 3BT1U 1FSCA 3EVSC 1H0JA 4BDTB 1JBDA 3KFDE 1L4WA 2CTXA 1LSIA 5DO6A 2J8BA 2BHIA 1TXBA 1MR6A 5DZ5A 1ZADA 1CODA 2FD6U 1FF4A 1FSSB 1MAHF 2BTXA 3VTSA 2MJ4A 5EBXA 1KBSA 1BTEA 1KU6B 2UX2A 1HC9B 3ERAA 1CREA 4XJJA 1IJCA 1ABTA 4IYEA 2QJ9C 2H5FA 1KBAA 1HAAA 3BT2U 1DRSA 1CDTA 2PJYB 1S4YA 2JVEA 4FAOE 6EBXA 2QJBC 3KFDI 2H7ZB 4UY2C 1RGJA 1VB0A 1CXOA 2MFAA 2MUPA 1F8UB 1KTZB 4ZQYA 5IMYC 1NTXA 1QM7A 1W6BA 1LJZA 1IKCA 1YWHA 1KS6A 2LA1A 1IDHA 1CDQA 1CB9A 1LXGA 1CHVS 1KL8A 1NORA 1RL5A 1ES7B 1IQ9A 3EBXA 3NH7A 1NXBA 1LX5B 3U73U 2MUOA 3LAQU
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OM4 A;  4AEA A;  1CXN A;  1KXI A;  1KBT A;  1B41 B;  1IDG A;  1NTN A;  2PJY C;  1KC4 A;  1F94 A;  3NEQ A;  2MJY A;  1JGK A;  1ONJ A;  2GOO B;  1LXH A;  2H8U A;  1CDR A;  1HC9 A;  2H64 B;  2UWR A;  1QKE A;  3FEV A;  1IDL A;  1REW C;  1G6M A;  1I02 A;  2ERA A;  1CTX A;  1TFS A;  2I9B E;  2QC1 A;  2MJ0 A;  2N99 A;  2VLW A;  1CRF A;  1FRA A;  4OM5 A;  2JQP A;  4BIK B;  2QJA C;  2NBT A;  4LFT A;  4RUD A;  1KFH A;  1M9Z A;  2H7Z A;  2K3G A;  1CDS A;  2H62 D;  1TGX A;  2CRS A;  1COE A;  4FAO C;  2CRT A;  3QB4 B;  2L03 A;  2X8B B;  1NEA A;  1UG4 A;  1FFJ A;  2CCX A;  1HAJ A;  2OFS A;  1TXA A;  3HH7 A;  4DO8 A;  1IK8 A;  1IDI A;  1BXP A;  1PLO A;  2H62 C;  4P7U A;  2GOO C;  1ERG A;  3U74 U;  4EY8 B;  1V6P A;  1ERA A;  2H64 C;  2MHY A;  2CDX A;  2LCR A;  1NYU A;  1NYS A;  1QKD A;  1FAS A;  1HOY A;  2L5S A;  1XT3 A;  2ABX A;  5DU1 A;  4HQP F;  2HLR A;  1JE9 A;  4QTI U;  2HLQ A;  5IMT D;  1CCQ A;  1CVO A;  3PLC A;  3NDS A;  3BT1 U;  1FSC A;  3EVS C;  1H0J A;  4BDT B;  1JBD A;  3KFD E;  1L4W A;  2CTX A;  1LSI A;  5DO6 A;  2J8B A;  2BHI A;  1TXB A;  1MR6 A;  5DZ5 A;  1ZAD A;  1COD A;  2FD6 U;  1FF4 A;  1FSS B;  1MAH F;  2BTX A;  3VTS A;  2MJ4 A;  5EBX A;  1KBS A;  1BTE A;  1KU6 B;  2UX2 A;  1HC9 B;  3ERA A;  1CRE A;  4XJJ A;  1IJC A;  1ABT A;  4IYE A;  2QJ9 C;  2H5F A;  1KBA A;  1HAA A;  3BT2 U;  1DRS A;  1CDT A;  2PJY B;  1S4Y A;  2JVE A;  4FAO E;  6EBX A;  2QJB C;  3KFD I;  2H7Z B;  4UY2 C;  1RGJ A;  1VB0 A;  1CXO A;  2MFA A;  2MUP A;  1F8U B;  1KTZ B;  4ZQY A;  5IMY C;  1NTX A;  1QM7 A;  1W6B A;  1LJZ A;  1IKC A;  1YWH A;  1KS6 A;  2LA1 A;  1IDH A;  1CDQ A;  1CB9 A;  1LXG A;  1CHV S;  1KL8 A;  1NOR A;  1RL5 A;  1ES7 B;  1IQ9 A;  3EBX A;  3NH7 A;  1NXB A;  1LX5 B;  3U73 U;  2MUO A;  3LAQ U; 
#chains in the Genus database with same CATH topology
 4OM4 A;  4AEA A;  1CXN A;  1KXI A;  1KBT A;  1B41 B;  1IDG A;  1NTN A;  2PJY C;  1KC4 A;  1F94 A;  3NEQ A;  2MJY A;  1JGK A;  1ONJ A;  2GOO B;  1LXH A;  2H8U A;  1CDR A;  1HC9 A;  2H64 B;  2UWR A;  1QKE A;  3FEV A;  1IDL A;  1REW C;  1G6M A;  1I02 A;  4KSN A;  2ERA A;  1CTX A;  1TFS A;  2I9B E;  2QC1 A;  2MJ0 A;  2N99 A;  2VLW A;  1CRF A;  1FRA A;  4OM5 A;  2JQP A;  4BIK B;  2QJA C;  2NBT A;  4LFT A;  4RUD A;  1KFH A;  1M9Z A;  2H7Z A;  2K3G A;  1CDS A;  2H62 D;  1TGX A;  2CRS A;  1COE A;  4FAO C;  2CRT A;  3QB4 B;  2L03 A;  2X8B B;  1NEA A;  1UG4 A;  1FFJ A;  2CCX A;  1HAJ A;  2OFS A;  1TXA A;  3HH7 A;  4DO8 A;  1IK8 A;  1IDI A;  1BXP A;  1PLO A;  2H62 C;  4P7U A;  2GOO C;  1ERG A;  3U74 U;  4EY8 B;  1V6P A;  1ERA A;  2H64 C;  2MHY A;  2CDX A;  2LCR A;  1NYU A;  1NYS A;  1QKD A;  1FAS A;  1HOY A;  2L5S A;  1XT3 A;  2ABX A;  5DU1 A;  4HQP F;  2HLR A;  1JE9 A;  4QTI U;  2HLQ A;  5IMT D;  1CCQ A;  1CVO A;  3PLC A;  3NDS A;  3BT1 U;  1FSC A;  3EVS C;  1H0J A;  4BDT B;  1JBD A;  3KFD E;  1L4W A;  2CTX A;  1LSI A;  5DO6 A;  2J8B A;  2BHI A;  1TXB A;  1MR6 A;  5DZ5 A;  1ZAD A;  1COD A;  2FD6 U;  1FF4 A;  1FSS B;  1MAH F;  2BTX A;  3VTS A;  2MJ4 A;  5EBX A;  1KBS A;  1BTE A;  1KU6 B;  2UX2 A;  1HC9 B;  3ERA A;  1CRE A;  4XJJ A;  1IJC A;  1ABT A;  4IYE A;  2QJ9 C;  2H5F A;  1KBA A;  1HAA A;  3BT2 U;  1DRS A;  1CDT A;  2PJY B;  1S4Y A;  2JVE A;  4FAO E;  6EBX A;  2QJB C;  3KFD I;  2H7Z B;  4UY2 C;  1RGJ A;  1VB0 A;  1CXO A;  2MFA A;  2MUP A;  1F8U B;  1KTZ B;  4ZQY A;  5IMY C;  1NTX A;  1QM7 A;  1W6B A;  1LJZ A;  1IKC A;  1YWH A;  1KS6 A;  2LA1 A;  1IDH A;  1CDQ A;  1CB9 A;  1LXG A;  1CHV S;  1KL8 A;  1NOR A;  1RL5 A;  1ES7 B;  1IQ9 A;  3EBX A;  3NH7 A;  1NXB A;  1LX5 B;  3U73 U;  2MUO A;  3LAQ U; 
#chains in the Genus database with same CATH homology
 4OM4 A;  4AEA A;  1CXN A;  1KXI A;  1KBT A;  1B41 B;  1IDG A;  1NTN A;  2PJY C;  1KC4 A;  1F94 A;  3NEQ A;  2MJY A;  1JGK A;  1ONJ A;  2GOO B;  1LXH A;  2H8U A;  1CDR A;  1HC9 A;  2H64 B;  2UWR A;  1QKE A;  3FEV A;  1IDL A;  1REW C;  1G6M A;  1I02 A;  4KSN A;  2ERA A;  1CTX A;  1TFS A;  2I9B E;  2QC1 A;  2MJ0 A;  2N99 A;  2VLW A;  1CRF A;  1FRA A;  4OM5 A;  2JQP A;  4BIK B;  2QJA C;  2NBT A;  4LFT A;  4RUD A;  1KFH A;  1M9Z A;  2H7Z A;  2K3G A;  1CDS A;  2H62 D;  1TGX A;  2CRS A;  1COE A;  4FAO C;  2CRT A;  3QB4 B;  2L03 A;  2X8B B;  1NEA A;  1UG4 A;  1FFJ A;  2CCX A;  1HAJ A;  2OFS A;  1TXA A;  3HH7 A;  4DO8 A;  1IK8 A;  1IDI A;  1BXP A;  1PLO A;  2H62 C;  4P7U A;  2GOO C;  1ERG A;  3U74 U;  4EY8 B;  1V6P A;  1ERA A;  2H64 C;  2MHY A;  2CDX A;  2LCR A;  1NYU A;  1NYS A;  1QKD A;  1FAS A;  1HOY A;  2L5S A;  1XT3 A;  2ABX A;  5DU1 A;  4HQP F;  2HLR A;  1JE9 A;  4QTI U;  2HLQ A;  5IMT D;  1CCQ A;  1CVO A;  3PLC A;  3NDS A;  3BT1 U;  1FSC A;  3EVS C;  1H0J A;  4BDT B;  1JBD A;  3KFD E;  1L4W A;  2CTX A;  1LSI A;  5DO6 A;  2J8B A;  2BHI A;  1TXB A;  1MR6 A;  5DZ5 A;  1ZAD A;  1COD A;  2FD6 U;  1FF4 A;  1FSS B;  1MAH F;  2BTX A;  3VTS A;  2MJ4 A;  5EBX A;  1KBS A;  1BTE A;  1KU6 B;  2UX2 A;  1HC9 B;  3ERA A;  1CRE A;  4XJJ A;  1IJC A;  1ABT A;  4IYE A;  2QJ9 C;  2H5F A;  1KBA A;  1HAA A;  3BT2 U;  1DRS A;  1CDT A;  2PJY B;  1S4Y A;  2JVE A;  4FAO E;  6EBX A;  2QJB C;  3KFD I;  2H7Z B;  4UY2 C;  1RGJ A;  1VB0 A;  1CXO A;  2MFA A;  2MUP A;  1F8U B;  1KTZ B;  4ZQY A;  5IMY C;  1NTX A;  1QM7 A;  1W6B A;  1LJZ A;  1IKC A;  1YWH A;  1KS6 A;  2LA1 A;  1IDH A;  1CDQ A;  1CB9 A;  1LXG A;  1CHV S;  1KL8 A;  1NOR A;  1RL5 A;  1ES7 B;  1IQ9 A;  3EBX A;  3NH7 A;  1NXB A;  1LX5 B;  3U73 U;  2MUO A;  3LAQ U; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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