1S4YA

Crystal structure of the activin/actriib extracellular domain
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
91
structure length
91
Chain Sequence
RECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors.
pubmed doi rcsb
molecule tags Transferase
source organism Mus musculus
molecule keywords Activin receptor type IIB precursor
total genus 22
structure length 91
sequence length 91
chains with identical sequence C
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2004-01-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 1s4yA00
2GOOC 2MHYA 1LXHA 2BTXA 1FSCA 1G6MA 3U73U 2J8BA 1CREA 1FSSB 2CRSA 3PLCA 1KFHA 1KBAA 1CDTA 2CRTA 1FF4A 1ONJA 4LFTA 3NH7A 1ES7B 1COEA 3BT2U 1TGXA 1TFSA 1CTXA 1JGKA 4XJJA 1IDIA 1QM7A 2CDXA 2QJ9C 2MJ4A 4IYEA 1HOYA 3EBXA 1CXNA 1LJZA 2H64C 5IMTD 1NYUA 3QB4B 3NDSA 4BIKB 3FEVA 2QJAC 1IQ9A 1KU6B 1HAAA 1QKDA 2GOOB 4DO8A 2UWRA 2HLQA 4QTIU 1PLOA 1IDLA 3KFDI 1IDHA 1KXIA 1NTXA 2H7ZB 1F94A 3LAQU 2X8BB 1KL8A 1HC9B 1IK8A 1CXOA 3NEQA 2I9BE 5DO6A 5DZ5A 1JBDA 5IMYC 2K3GA 2NBTA 2MJ0A 1REWC 1IDGA 2H64B 1CDQA 1B41B 4ZQYA 4OM5A 1XT3A 1IKCA 3U74U 2UX2A 1LXGA 4FAOE 1NTNA 4P7UA 1ABTA 2CTXA 6EBXA 1CODA 1RL5A 1FFJA 2PJYC 1KBTA 1JE9A 2L03A 2H8UA 1CDRA 4EY8B 1KTZB 2BHIA 2H62C 2QC1A 3HH7A 1DRSA 1KBSA 1NYSA 4HQPF 2H7ZA 1CRFA 1F8UB 1FASA 4OM4A 1CB9A 1NXBA 2MJYA 1W6BA 1HC9A 2ERAA 2OFSA 1S4YA 1CDSA 4FAOC 1HAJA 2JQPA 3ERAA 2HLRA 1TXBA 2CCXA 1LX5B 2H5FA 1ERGA 1MAHF 1YWHA 2PJYB 1TXAA 1MR6A 1M9ZA 2N99A 4BDTB 1ZADA 1ERAA 1IJCA 1FRAA 3EVSC 1H0JA 1NEAA 2MFAA 2LA1A 4UY2C 2FD6U 5EBXA 1BXPA 1RGJA 2LCRA 2VLWA 1LSIA 1KS6A 1NORA 2JVEA 1VB0A 1L4WA 2MUOA 1BTEA 1CHVS 2QJBC 1CVOA 2L5SA 1CCQA 2MUPA 5DU1A 3BT1U 2H62D 3KFDE 1I02A 1V6PA 2ABXA 3VTSA 4RUDA 4AEAA 1KC4A 1QKEA 1UG4A
chains in the Genus database with same CATH superfamily
2GOOC 2MHYA 1LXHA 2BTXA 1FSCA 1G6MA 3U73U 2J8BA 1CREA 1FSSB 2CRSA 3PLCA 1KFHA 1KBAA 1CDTA 2CRTA 1FF4A 1ONJA 4LFTA 3NH7A 1ES7B 1COEA 3BT2U 1TGXA 1TFSA 1CTXA 1JGKA 4XJJA 1IDIA 1QM7A 2CDXA 2QJ9C 2MJ4A 4IYEA 1HOYA 3EBXA 1CXNA 1LJZA 2H64C 5IMTD 1NYUA 3QB4B 3NDSA 4BIKB 3FEVA 2QJAC 1IQ9A 1KU6B 1HAAA 1QKDA 2GOOB 4DO8A 2UWRA 2HLQA 4QTIU 1PLOA 1IDLA 3KFDI 1IDHA 1KXIA 1NTXA 2H7ZB 1F94A 3LAQU 2X8BB 1KL8A 1HC9B 1IK8A 1CXOA 3NEQA 2I9BE 5DO6A 5DZ5A 1JBDA 5IMYC 2K3GA 2NBTA 2MJ0A 1REWC 1IDGA 2H64B 1CDQA 1B41B 4ZQYA 4OM5A 1XT3A 1IKCA 3U74U 2UX2A 1LXGA 4FAOE 1NTNA 4P7UA 1ABTA 2CTXA 6EBXA 1CODA 1RL5A 1FFJA 2PJYC 1KBTA 1JE9A 2L03A 4KSNA 2H8UA 1CDRA 4EY8B 1KTZB 2BHIA 2H62C 2QC1A 3HH7A 1DRSA 1KBSA 1NYSA 4HQPF 2H7ZA 1CRFA 1F8UB 1FASA 4OM4A 1CB9A 1NXBA 2MJYA 1W6BA 1HC9A 2ERAA 2OFSA 1S4YA 1CDSA 4FAOC 1HAJA 2JQPA 3ERAA 2HLRA 1TXBA 2CCXA 1LX5B 2H5FA 1ERGA 1MAHF 1YWHA 2PJYB 1TXAA 1MR6A 1M9ZA 2N99A 4BDTB 1ZADA 1ERAA 1IJCA 1FRAA 3EVSC 1H0JA 1NEAA 2MFAA 2LA1A 4UY2C 2FD6U 5EBXA 1BXPA 1RGJA 2LCRA 2VLWA 1LSIA 1KS6A 1NORA 2JVEA 1VB0A 1L4WA 2MUOA 1BTEA 1CHVS 2QJBC 1CVOA 2L5SA 1CCQA 2MUPA 5DU1A 3BT1U 2H62D 3KFDE 1I02A 1V6PA 2ABXA 3VTSA 4RUDA 4AEAA 1KC4A 1QKEA 1UG4A
chains in the Genus database with same CATH topology
2GOOC 2MHYA 1LXHA 2BTXA 1FSCA 1G6MA 3U73U 2J8BA 1CREA 1FSSB 2CRSA 3PLCA 1KFHA 1KBAA 1CDTA 2CRTA 1FF4A 1ONJA 4LFTA 3NH7A 1ES7B 1COEA 3BT2U 1TGXA 1TFSA 1CTXA 1JGKA 4XJJA 1IDIA 1QM7A 2CDXA 2QJ9C 2MJ4A 4IYEA 1HOYA 3EBXA 1CXNA 1LJZA 2H64C 5IMTD 1NYUA 3QB4B 3NDSA 4BIKB 3FEVA 2QJAC 1IQ9A 1KU6B 1HAAA 1QKDA 2GOOB 4DO8A 2UWRA 2HLQA 4QTIU 1PLOA 1IDLA 3KFDI 1IDHA 1KXIA 1NTXA 2H7ZB 1F94A 3LAQU 2X8BB 1KL8A 1HC9B 1IK8A 1CXOA 3NEQA 2I9BE 5DO6A 5DZ5A 1JBDA 5IMYC 2K3GA 2NBTA 2MJ0A 1REWC 1IDGA 2H64B 1CDQA 1B41B 4ZQYA 4OM5A 1XT3A 1IKCA 3U74U 2UX2A 1LXGA 4FAOE 1NTNA 4P7UA 1ABTA 2CTXA 6EBXA 1CODA 1RL5A 1FFJA 2PJYC 1KBTA 1JE9A 2L03A 4KSNA 2H8UA 1CDRA 4EY8B 1KTZB 2BHIA 2H62C 2QC1A 3HH7A 1DRSA 1KBSA 1NYSA 4HQPF 2H7ZA 1CRFA 1F8UB 1FASA 4OM4A 1CB9A 1NXBA 2MJYA 1W6BA 1HC9A 2ERAA 2OFSA 1S4YA 1CDSA 4FAOC 1HAJA 2JQPA 3ERAA 2HLRA 1TXBA 2CCXA 1LX5B 2H5FA 1ERGA 1MAHF 1YWHA 2PJYB 1TXAA 1MR6A 1M9ZA 2N99A 4BDTB 1ZADA 1ERAA 1IJCA 1FRAA 3EVSC 1H0JA 1NEAA 2MFAA 2LA1A 4UY2C 2FD6U 5EBXA 1BXPA 1RGJA 2LCRA 2VLWA 1LSIA 1KS6A 1NORA 2JVEA 1VB0A 1L4WA 2MUOA 1BTEA 1CHVS 2QJBC 1CVOA 2L5SA 1CCQA 2MUPA 5DU1A 3BT1U 2H62D 3KFDE 1I02A 1V6PA 2ABXA 3VTSA 4RUDA 4AEAA 1KC4A 1QKEA 1UG4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GOO C;  2MHY A;  1LXH A;  2BTX A;  1FSC A;  1G6M A;  3U73 U;  2J8B A;  1CRE A;  1FSS B;  2CRS A;  3PLC A;  1KFH A;  1KBA A;  1CDT A;  2CRT A;  1FF4 A;  1ONJ A;  4LFT A;  3NH7 A;  1ES7 B;  1COE A;  3BT2 U;  1TGX A;  1TFS A;  1CTX A;  1JGK A;  4XJJ A;  1IDI A;  1QM7 A;  2CDX A;  2QJ9 C;  2MJ4 A;  4IYE A;  1HOY A;  3EBX A;  1CXN A;  1LJZ A;  2H64 C;  5IMT D;  1NYU A;  3QB4 B;  3NDS A;  4BIK B;  3FEV A;  2QJA C;  1IQ9 A;  1KU6 B;  1HAA A;  1QKD A;  2GOO B;  4DO8 A;  2UWR A;  2HLQ A;  4QTI U;  1PLO A;  1IDL A;  3KFD I;  1IDH A;  1KXI A;  1NTX A;  2H7Z B;  1F94 A;  3LAQ U;  2X8B B;  1KL8 A;  1HC9 B;  1IK8 A;  1CXO A;  3NEQ A;  2I9B E;  5DO6 A;  5DZ5 A;  1JBD A;  5IMY C;  2K3G A;  2NBT A;  2MJ0 A;  1REW C;  1IDG A;  2H64 B;  1CDQ A;  1B41 B;  4ZQY A;  4OM5 A;  1XT3 A;  1IKC A;  3U74 U;  2UX2 A;  1LXG A;  4FAO E;  1NTN A;  4P7U A;  1ABT A;  2CTX A;  6EBX A;  1COD A;  1RL5 A;  1FFJ A;  2PJY C;  1KBT A;  1JE9 A;  2L03 A;  2H8U A;  1CDR A;  4EY8 B;  1KTZ B;  2BHI A;  2H62 C;  2QC1 A;  3HH7 A;  1DRS A;  1KBS A;  1NYS A;  4HQP F;  2H7Z A;  1CRF A;  1F8U B;  1FAS A;  4OM4 A;  1CB9 A;  1NXB A;  2MJY A;  1W6B A;  1HC9 A;  2ERA A;  2OFS A;  1S4Y A;  1CDS A;  4FAO C;  1HAJ A;  2JQP A;  3ERA A;  2HLR A;  1TXB A;  2CCX A;  1LX5 B;  2H5F A;  1ERG A;  1MAH F;  1YWH A;  2PJY B;  1TXA A;  1MR6 A;  1M9Z A;  2N99 A;  4BDT B;  1ZAD A;  1ERA A;  1IJC A;  1FRA A;  3EVS C;  1H0J A;  1NEA A;  2MFA A;  2LA1 A;  4UY2 C;  2FD6 U;  5EBX A;  1BXP A;  1RGJ A;  2LCR A;  2VLW A;  1LSI A;  1KS6 A;  1NOR A;  2JVE A;  1VB0 A;  1L4W A;  2MUO A;  1BTE A;  1CHV S;  2QJB C;  1CVO A;  2L5S A;  1CCQ A;  2MUP A;  5DU1 A;  3BT1 U;  2H62 D;  3KFD E;  1I02 A;  1V6P A;  2ABX A;  3VTS A;  4RUD A;  4AEA A;  1KC4 A;  1QKE A;  1UG4 A; 
#chains in the Genus database with same CATH topology
 2GOO C;  2MHY A;  1LXH A;  2BTX A;  1FSC A;  1G6M A;  3U73 U;  2J8B A;  1CRE A;  1FSS B;  2CRS A;  3PLC A;  1KFH A;  1KBA A;  1CDT A;  2CRT A;  1FF4 A;  1ONJ A;  4LFT A;  3NH7 A;  1ES7 B;  1COE A;  3BT2 U;  1TGX A;  1TFS A;  1CTX A;  1JGK A;  4XJJ A;  1IDI A;  1QM7 A;  2CDX A;  2QJ9 C;  2MJ4 A;  4IYE A;  1HOY A;  3EBX A;  1CXN A;  1LJZ A;  2H64 C;  5IMT D;  1NYU A;  3QB4 B;  3NDS A;  4BIK B;  3FEV A;  2QJA C;  1IQ9 A;  1KU6 B;  1HAA A;  1QKD A;  2GOO B;  4DO8 A;  2UWR A;  2HLQ A;  4QTI U;  1PLO A;  1IDL A;  3KFD I;  1IDH A;  1KXI A;  1NTX A;  2H7Z B;  1F94 A;  3LAQ U;  2X8B B;  1KL8 A;  1HC9 B;  1IK8 A;  1CXO A;  3NEQ A;  2I9B E;  5DO6 A;  5DZ5 A;  1JBD A;  5IMY C;  2K3G A;  2NBT A;  2MJ0 A;  1REW C;  1IDG A;  2H64 B;  1CDQ A;  1B41 B;  4ZQY A;  4OM5 A;  1XT3 A;  1IKC A;  3U74 U;  2UX2 A;  1LXG A;  4FAO E;  1NTN A;  4P7U A;  1ABT A;  2CTX A;  6EBX A;  1COD A;  1RL5 A;  1FFJ A;  2PJY C;  1KBT A;  1JE9 A;  2L03 A;  4KSN A;  2H8U A;  1CDR A;  4EY8 B;  1KTZ B;  2BHI A;  2H62 C;  2QC1 A;  3HH7 A;  1DRS A;  1KBS A;  1NYS A;  4HQP F;  2H7Z A;  1CRF A;  1F8U B;  1FAS A;  4OM4 A;  1CB9 A;  1NXB A;  2MJY A;  1W6B A;  1HC9 A;  2ERA A;  2OFS A;  1S4Y A;  1CDS A;  4FAO C;  1HAJ A;  2JQP A;  3ERA A;  2HLR A;  1TXB A;  2CCX A;  1LX5 B;  2H5F A;  1ERG A;  1MAH F;  1YWH A;  2PJY B;  1TXA A;  1MR6 A;  1M9Z A;  2N99 A;  4BDT B;  1ZAD A;  1ERA A;  1IJC A;  1FRA A;  3EVS C;  1H0J A;  1NEA A;  2MFA A;  2LA1 A;  4UY2 C;  2FD6 U;  5EBX A;  1BXP A;  1RGJ A;  2LCR A;  2VLW A;  1LSI A;  1KS6 A;  1NOR A;  2JVE A;  1VB0 A;  1L4W A;  2MUO A;  1BTE A;  1CHV S;  2QJB C;  1CVO A;  2L5S A;  1CCQ A;  2MUP A;  5DU1 A;  3BT1 U;  2H62 D;  3KFD E;  1I02 A;  1V6P A;  2ABX A;  3VTS A;  4RUD A;  4AEA A;  1KC4 A;  1QKE A;  1UG4 A; 
#chains in the Genus database with same CATH homology
 2GOO C;  2MHY A;  1LXH A;  2BTX A;  1FSC A;  1G6M A;  3U73 U;  2J8B A;  1CRE A;  1FSS B;  2CRS A;  3PLC A;  1KFH A;  1KBA A;  1CDT A;  2CRT A;  1FF4 A;  1ONJ A;  4LFT A;  3NH7 A;  1ES7 B;  1COE A;  3BT2 U;  1TGX A;  1TFS A;  1CTX A;  1JGK A;  4XJJ A;  1IDI A;  1QM7 A;  2CDX A;  2QJ9 C;  2MJ4 A;  4IYE A;  1HOY A;  3EBX A;  1CXN A;  1LJZ A;  2H64 C;  5IMT D;  1NYU A;  3QB4 B;  3NDS A;  4BIK B;  3FEV A;  2QJA C;  1IQ9 A;  1KU6 B;  1HAA A;  1QKD A;  2GOO B;  4DO8 A;  2UWR A;  2HLQ A;  4QTI U;  1PLO A;  1IDL A;  3KFD I;  1IDH A;  1KXI A;  1NTX A;  2H7Z B;  1F94 A;  3LAQ U;  2X8B B;  1KL8 A;  1HC9 B;  1IK8 A;  1CXO A;  3NEQ A;  2I9B E;  5DO6 A;  5DZ5 A;  1JBD A;  5IMY C;  2K3G A;  2NBT A;  2MJ0 A;  1REW C;  1IDG A;  2H64 B;  1CDQ A;  1B41 B;  4ZQY A;  4OM5 A;  1XT3 A;  1IKC A;  3U74 U;  2UX2 A;  1LXG A;  4FAO E;  1NTN A;  4P7U A;  1ABT A;  2CTX A;  6EBX A;  1COD A;  1RL5 A;  1FFJ A;  2PJY C;  1KBT A;  1JE9 A;  2L03 A;  4KSN A;  2H8U A;  1CDR A;  4EY8 B;  1KTZ B;  2BHI A;  2H62 C;  2QC1 A;  3HH7 A;  1DRS A;  1KBS A;  1NYS A;  4HQP F;  2H7Z A;  1CRF A;  1F8U B;  1FAS A;  4OM4 A;  1CB9 A;  1NXB A;  2MJY A;  1W6B A;  1HC9 A;  2ERA A;  2OFS A;  1S4Y A;  1CDS A;  4FAO C;  1HAJ A;  2JQP A;  3ERA A;  2HLR A;  1TXB A;  2CCX A;  1LX5 B;  2H5F A;  1ERG A;  1MAH F;  1YWH A;  2PJY B;  1TXA A;  1MR6 A;  1M9Z A;  2N99 A;  4BDT B;  1ZAD A;  1ERA A;  1IJC A;  1FRA A;  3EVS C;  1H0J A;  1NEA A;  2MFA A;  2LA1 A;  4UY2 C;  2FD6 U;  5EBX A;  1BXP A;  1RGJ A;  2LCR A;  2VLW A;  1LSI A;  1KS6 A;  1NOR A;  2JVE A;  1VB0 A;  1L4W A;  2MUO A;  1BTE A;  1CHV S;  2QJB C;  1CVO A;  2L5S A;  1CCQ A;  2MUP A;  5DU1 A;  3BT1 U;  2H62 D;  3KFD E;  1I02 A;  1V6P A;  2ABX A;  3VTS A;  4RUD A;  4AEA A;  1KC4 A;  1QKE A;  1UG4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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