2H62D

Crystal structure of a ternary ligand-receptor complex of bmp-2
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
93
structure length
93
Chain Sequence
AETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords Bone morphogenetic protein 2
total genus 21
structure length 93
sequence length 93
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2006-05-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2h62D00
1RGJA 1W6BA 1QKDA 2CCXA 3NEQA 4DO8A 2N99A 4BDTB 1NYSA 2H64C 1LSIA 2L03A 5DO6A 1I02A 2H8UA 4FAOE 1HOYA 5IMYC 2PJYB 2CRTA 2LA1A 1KC4A 1CDRA 3EVSC 2MJ0A 1IDHA 3EBXA 1REWC 2HLQA 6EBXA 2QJBC 1NYUA 1L4WA 1CXNA 1NEAA 4LFTA 5IMTD 1ERAA 1CTXA 2MJYA 3PLCA 3BT1U 2JQPA 2QJAC 3ERAA 1CREA 1LJZA 3LAQU 1ABTA 1B41B 2VLWA 2MFAA 2MUPA 2J8BA 1FFJA 1JBDA 1COEA 1TFSA 1HAJA 2MHYA 2CRSA 2QC1A 1KL8A 2GOOC 1F8UB 2QJ9C 1IKCA 1UG4A 2H7ZA 1QKEA 1IDLA 1ONJA 1MR6A 1RL5A 1TXBA 3U74U 2H5FA 2HLRA 4HQPF 1CODA 5EBXA 3HH7A 1KBTA 2L5SA 1YWHA 2LCRA 1NTNA 1FASA 2CTXA 2H7ZB 1DRSA 4AEAA 1CVOA 5DZ5A 2UX2A 2GOOB 3NDSA 2H64B 1IQ9A 1M9ZA 2MUOA 1BTEA 1NORA 2BTXA 4XJJA 2H62C 1TGXA 1TXAA 3KFDE 4RUDA 2OFSA 4OM4A 1ZADA 1CDQA 1FRAA 3NH7A 1KBSA 2UWRA 4FAOC 1LXGA 1KFHA 1ES7B 2H62D 1BXPA 1CHVS 1IK8A 1KU6B 1NTXA 1S4YA 1IDIA 3QB4B 2I9BE 2JVEA 4QTIU 4OM5A 3U73U 1KBAA 4UY2C 2ABXA 1CXOA 1JGKA 1QM7A 2BHIA 2FD6U 3BT2U 1NXBA 1CRFA 1KS6A 1CCQA 2PJYC 4BIKB 1CB9A 1LX5B 1HC9A 1CDSA 4ZQYA 2NBTA 4IYEA 1IJCA 1PLOA 1CDTA 2K3GA 1H0JA 4EY8B 5DU1A 1HAAA 1IDGA 2ERAA 1FF4A 1G6MA 1HC9B 1V6PA 3VTSA 1VB0A 3KFDI 1FSSB 2CDXA 2MJ4A 1ERGA 3FEVA 1F94A 1JE9A 2X8BB 1KTZB 1KXIA 1LXHA 1FSCA 4P7UA 1XT3A 1MAHF
chains in the Genus database with same CATH superfamily
1RGJA 1W6BA 1QKDA 2CCXA 3NEQA 4DO8A 2N99A 4BDTB 1NYSA 2H64C 1LSIA 2L03A 5DO6A 1I02A 2H8UA 4FAOE 1HOYA 5IMYC 2PJYB 2CRTA 2LA1A 1KC4A 1CDRA 3EVSC 2MJ0A 1IDHA 3EBXA 1REWC 2HLQA 6EBXA 2QJBC 1NYUA 1L4WA 1CXNA 1NEAA 4LFTA 5IMTD 1ERAA 1CTXA 2MJYA 3PLCA 3BT1U 2JQPA 2QJAC 3ERAA 1CREA 1LJZA 3LAQU 1ABTA 1B41B 2VLWA 2MFAA 2MUPA 2J8BA 1FFJA 1JBDA 1COEA 1TFSA 1HAJA 2MHYA 2CRSA 2QC1A 1KL8A 2GOOC 1F8UB 2QJ9C 1IKCA 1UG4A 2H7ZA 1QKEA 1IDLA 1ONJA 1MR6A 1RL5A 1TXBA 3U74U 2H5FA 2HLRA 4HQPF 1CODA 5EBXA 3HH7A 1KBTA 2L5SA 1YWHA 2LCRA 1NTNA 1FASA 2CTXA 2H7ZB 1DRSA 4AEAA 1CVOA 5DZ5A 2UX2A 2GOOB 3NDSA 2H64B 1IQ9A 1M9ZA 2MUOA 1BTEA 1NORA 2BTXA 4XJJA 2H62C 1TGXA 1TXAA 3KFDE 4RUDA 2OFSA 4OM4A 1ZADA 1CDQA 1FRAA 3NH7A 1KBSA 2UWRA 4FAOC 1LXGA 1KFHA 1ES7B 2H62D 1BXPA 1CHVS 1IK8A 1KU6B 1NTXA 1S4YA 1IDIA 3QB4B 2I9BE 2JVEA 4QTIU 4OM5A 3U73U 1KBAA 4UY2C 2ABXA 1CXOA 1JGKA 1QM7A 2BHIA 2FD6U 3BT2U 1NXBA 1CRFA 1KS6A 1CCQA 2PJYC 4BIKB 1CB9A 1LX5B 1HC9A 1CDSA 4ZQYA 2NBTA 4IYEA 1IJCA 1PLOA 1CDTA 2K3GA 1H0JA 4EY8B 5DU1A 1HAAA 1IDGA 2ERAA 1FF4A 1G6MA 1HC9B 1V6PA 3VTSA 1VB0A 3KFDI 1FSSB 2CDXA 2MJ4A 1ERGA 4KSNA 3FEVA 1F94A 1JE9A 2X8BB 1KTZB 1KXIA 1LXHA 1FSCA 4P7UA 1XT3A 1MAHF
chains in the Genus database with same CATH topology
1RGJA 1W6BA 1QKDA 2CCXA 3NEQA 4DO8A 2N99A 4BDTB 1NYSA 2H64C 1LSIA 2L03A 5DO6A 1I02A 2H8UA 4FAOE 1HOYA 5IMYC 2PJYB 2CRTA 2LA1A 1KC4A 1CDRA 3EVSC 2MJ0A 1IDHA 3EBXA 1REWC 2HLQA 6EBXA 2QJBC 1NYUA 1L4WA 1CXNA 1NEAA 4LFTA 5IMTD 1ERAA 1CTXA 2MJYA 3PLCA 3BT1U 2JQPA 2QJAC 3ERAA 1CREA 1LJZA 3LAQU 1ABTA 1B41B 2VLWA 2MFAA 2MUPA 2J8BA 1FFJA 1JBDA 1COEA 1TFSA 1HAJA 2MHYA 2CRSA 2QC1A 1KL8A 2GOOC 1F8UB 2QJ9C 1IKCA 1UG4A 2H7ZA 1QKEA 1IDLA 1ONJA 1MR6A 1RL5A 1TXBA 3U74U 2H5FA 2HLRA 4HQPF 1CODA 5EBXA 3HH7A 1KBTA 2L5SA 1YWHA 2LCRA 1NTNA 1FASA 2CTXA 2H7ZB 1DRSA 4AEAA 1CVOA 5DZ5A 2UX2A 2GOOB 3NDSA 2H64B 1IQ9A 1M9ZA 2MUOA 1BTEA 1NORA 2BTXA 4XJJA 2H62C 1TGXA 1TXAA 3KFDE 4RUDA 2OFSA 4OM4A 1ZADA 1CDQA 1FRAA 3NH7A 1KBSA 2UWRA 4FAOC 1LXGA 1KFHA 1ES7B 2H62D 1BXPA 1CHVS 1IK8A 1KU6B 1NTXA 1S4YA 1IDIA 3QB4B 2I9BE 2JVEA 4QTIU 4OM5A 3U73U 1KBAA 4UY2C 2ABXA 1CXOA 1JGKA 1QM7A 2BHIA 2FD6U 3BT2U 1NXBA 1CRFA 1KS6A 1CCQA 2PJYC 4BIKB 1CB9A 1LX5B 1HC9A 1CDSA 4ZQYA 2NBTA 4IYEA 1IJCA 1PLOA 1CDTA 2K3GA 1H0JA 4EY8B 5DU1A 1HAAA 1IDGA 2ERAA 1FF4A 1G6MA 1HC9B 1V6PA 3VTSA 1VB0A 3KFDI 1FSSB 2CDXA 2MJ4A 1ERGA 4KSNA 3FEVA 1F94A 1JE9A 2X8BB 1KTZB 1KXIA 1LXHA 1FSCA 4P7UA 1XT3A 1MAHF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RGJ A;  1W6B A;  1QKD A;  2CCX A;  3NEQ A;  4DO8 A;  2N99 A;  4BDT B;  1NYS A;  2H64 C;  1LSI A;  2L03 A;  5DO6 A;  1I02 A;  2H8U A;  4FAO E;  1HOY A;  5IMY C;  2PJY B;  2CRT A;  2LA1 A;  1KC4 A;  1CDR A;  3EVS C;  2MJ0 A;  1IDH A;  3EBX A;  1REW C;  2HLQ A;  6EBX A;  2QJB C;  1NYU A;  1L4W A;  1CXN A;  1NEA A;  4LFT A;  5IMT D;  1ERA A;  1CTX A;  2MJY A;  3PLC A;  3BT1 U;  2JQP A;  2QJA C;  3ERA A;  1CRE A;  1LJZ A;  3LAQ U;  1ABT A;  1B41 B;  2VLW A;  2MFA A;  2MUP A;  2J8B A;  1FFJ A;  1JBD A;  1COE A;  1TFS A;  1HAJ A;  2MHY A;  2CRS A;  2QC1 A;  1KL8 A;  2GOO C;  1F8U B;  2QJ9 C;  1IKC A;  1UG4 A;  2H7Z A;  1QKE A;  1IDL A;  1ONJ A;  1MR6 A;  1RL5 A;  1TXB A;  3U74 U;  2H5F A;  2HLR A;  4HQP F;  1COD A;  5EBX A;  3HH7 A;  1KBT A;  2L5S A;  1YWH A;  2LCR A;  1NTN A;  1FAS A;  2CTX A;  2H7Z B;  1DRS A;  4AEA A;  1CVO A;  5DZ5 A;  2UX2 A;  2GOO B;  3NDS A;  2H64 B;  1IQ9 A;  1M9Z A;  2MUO A;  1BTE A;  1NOR A;  2BTX A;  4XJJ A;  2H62 C;  1TGX A;  1TXA A;  3KFD E;  4RUD A;  2OFS A;  4OM4 A;  1ZAD A;  1CDQ A;  1FRA A;  3NH7 A;  1KBS A;  2UWR A;  4FAO C;  1LXG A;  1KFH A;  1ES7 B;  2H62 D;  1BXP A;  1CHV S;  1IK8 A;  1KU6 B;  1NTX A;  1S4Y A;  1IDI A;  3QB4 B;  2I9B E;  2JVE A;  4QTI U;  4OM5 A;  3U73 U;  1KBA A;  4UY2 C;  2ABX A;  1CXO A;  1JGK A;  1QM7 A;  2BHI A;  2FD6 U;  3BT2 U;  1NXB A;  1CRF A;  1KS6 A;  1CCQ A;  2PJY C;  4BIK B;  1CB9 A;  1LX5 B;  1HC9 A;  1CDS A;  4ZQY A;  2NBT A;  4IYE A;  1IJC A;  1PLO A;  1CDT A;  2K3G A;  1H0J A;  4EY8 B;  5DU1 A;  1HAA A;  1IDG A;  2ERA A;  1FF4 A;  1G6M A;  1HC9 B;  1V6P A;  3VTS A;  1VB0 A;  3KFD I;  1FSS B;  2CDX A;  2MJ4 A;  1ERG A;  3FEV A;  1F94 A;  1JE9 A;  2X8B B;  1KTZ B;  1KXI A;  1LXH A;  1FSC A;  4P7U A;  1XT3 A;  1MAH F; 
#chains in the Genus database with same CATH topology
 1RGJ A;  1W6B A;  1QKD A;  2CCX A;  3NEQ A;  4DO8 A;  2N99 A;  4BDT B;  1NYS A;  2H64 C;  1LSI A;  2L03 A;  5DO6 A;  1I02 A;  2H8U A;  4FAO E;  1HOY A;  5IMY C;  2PJY B;  2CRT A;  2LA1 A;  1KC4 A;  1CDR A;  3EVS C;  2MJ0 A;  1IDH A;  3EBX A;  1REW C;  2HLQ A;  6EBX A;  2QJB C;  1NYU A;  1L4W A;  1CXN A;  1NEA A;  4LFT A;  5IMT D;  1ERA A;  1CTX A;  2MJY A;  3PLC A;  3BT1 U;  2JQP A;  2QJA C;  3ERA A;  1CRE A;  1LJZ A;  3LAQ U;  1ABT A;  1B41 B;  2VLW A;  2MFA A;  2MUP A;  2J8B A;  1FFJ A;  1JBD A;  1COE A;  1TFS A;  1HAJ A;  2MHY A;  2CRS A;  2QC1 A;  1KL8 A;  2GOO C;  1F8U B;  2QJ9 C;  1IKC A;  1UG4 A;  2H7Z A;  1QKE A;  1IDL A;  1ONJ A;  1MR6 A;  1RL5 A;  1TXB A;  3U74 U;  2H5F A;  2HLR A;  4HQP F;  1COD A;  5EBX A;  3HH7 A;  1KBT A;  2L5S A;  1YWH A;  2LCR A;  1NTN A;  1FAS A;  2CTX A;  2H7Z B;  1DRS A;  4AEA A;  1CVO A;  5DZ5 A;  2UX2 A;  2GOO B;  3NDS A;  2H64 B;  1IQ9 A;  1M9Z A;  2MUO A;  1BTE A;  1NOR A;  2BTX A;  4XJJ A;  2H62 C;  1TGX A;  1TXA A;  3KFD E;  4RUD A;  2OFS A;  4OM4 A;  1ZAD A;  1CDQ A;  1FRA A;  3NH7 A;  1KBS A;  2UWR A;  4FAO C;  1LXG A;  1KFH A;  1ES7 B;  2H62 D;  1BXP A;  1CHV S;  1IK8 A;  1KU6 B;  1NTX A;  1S4Y A;  1IDI A;  3QB4 B;  2I9B E;  2JVE A;  4QTI U;  4OM5 A;  3U73 U;  1KBA A;  4UY2 C;  2ABX A;  1CXO A;  1JGK A;  1QM7 A;  2BHI A;  2FD6 U;  3BT2 U;  1NXB A;  1CRF A;  1KS6 A;  1CCQ A;  2PJY C;  4BIK B;  1CB9 A;  1LX5 B;  1HC9 A;  1CDS A;  4ZQY A;  2NBT A;  4IYE A;  1IJC A;  1PLO A;  1CDT A;  2K3G A;  1H0J A;  4EY8 B;  5DU1 A;  1HAA A;  1IDG A;  2ERA A;  1FF4 A;  1G6M A;  1HC9 B;  1V6P A;  3VTS A;  1VB0 A;  3KFD I;  1FSS B;  2CDX A;  2MJ4 A;  1ERG A;  4KSN A;  3FEV A;  1F94 A;  1JE9 A;  2X8B B;  1KTZ B;  1KXI A;  1LXH A;  1FSC A;  4P7U A;  1XT3 A;  1MAH F; 
#chains in the Genus database with same CATH homology
 1RGJ A;  1W6B A;  1QKD A;  2CCX A;  3NEQ A;  4DO8 A;  2N99 A;  4BDT B;  1NYS A;  2H64 C;  1LSI A;  2L03 A;  5DO6 A;  1I02 A;  2H8U A;  4FAO E;  1HOY A;  5IMY C;  2PJY B;  2CRT A;  2LA1 A;  1KC4 A;  1CDR A;  3EVS C;  2MJ0 A;  1IDH A;  3EBX A;  1REW C;  2HLQ A;  6EBX A;  2QJB C;  1NYU A;  1L4W A;  1CXN A;  1NEA A;  4LFT A;  5IMT D;  1ERA A;  1CTX A;  2MJY A;  3PLC A;  3BT1 U;  2JQP A;  2QJA C;  3ERA A;  1CRE A;  1LJZ A;  3LAQ U;  1ABT A;  1B41 B;  2VLW A;  2MFA A;  2MUP A;  2J8B A;  1FFJ A;  1JBD A;  1COE A;  1TFS A;  1HAJ A;  2MHY A;  2CRS A;  2QC1 A;  1KL8 A;  2GOO C;  1F8U B;  2QJ9 C;  1IKC A;  1UG4 A;  2H7Z A;  1QKE A;  1IDL A;  1ONJ A;  1MR6 A;  1RL5 A;  1TXB A;  3U74 U;  2H5F A;  2HLR A;  4HQP F;  1COD A;  5EBX A;  3HH7 A;  1KBT A;  2L5S A;  1YWH A;  2LCR A;  1NTN A;  1FAS A;  2CTX A;  2H7Z B;  1DRS A;  4AEA A;  1CVO A;  5DZ5 A;  2UX2 A;  2GOO B;  3NDS A;  2H64 B;  1IQ9 A;  1M9Z A;  2MUO A;  1BTE A;  1NOR A;  2BTX A;  4XJJ A;  2H62 C;  1TGX A;  1TXA A;  3KFD E;  4RUD A;  2OFS A;  4OM4 A;  1ZAD A;  1CDQ A;  1FRA A;  3NH7 A;  1KBS A;  2UWR A;  4FAO C;  1LXG A;  1KFH A;  1ES7 B;  2H62 D;  1BXP A;  1CHV S;  1IK8 A;  1KU6 B;  1NTX A;  1S4Y A;  1IDI A;  3QB4 B;  2I9B E;  2JVE A;  4QTI U;  4OM5 A;  3U73 U;  1KBA A;  4UY2 C;  2ABX A;  1CXO A;  1JGK A;  1QM7 A;  2BHI A;  2FD6 U;  3BT2 U;  1NXB A;  1CRF A;  1KS6 A;  1CCQ A;  2PJY C;  4BIK B;  1CB9 A;  1LX5 B;  1HC9 A;  1CDS A;  4ZQY A;  2NBT A;  4IYE A;  1IJC A;  1PLO A;  1CDT A;  2K3G A;  1H0J A;  4EY8 B;  5DU1 A;  1HAA A;  1IDG A;  2ERA A;  1FF4 A;  1G6M A;  1HC9 B;  1V6P A;  3VTS A;  1VB0 A;  3KFD I;  1FSS B;  2CDX A;  2MJ4 A;  1ERG A;  4KSN A;  3FEV A;  1F94 A;  1JE9 A;  2X8B B;  1KTZ B;  1KXI A;  1LXH A;  1FSC A;  4P7U A;  1XT3 A;  1MAH F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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