2H64B

Crystal structure of a ternary ligand-receptor complex of bmp-2
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
92
structure length
92
Chain Sequence
TLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor
source organism Homo sapiens
publication title A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
pubmed doi rcsb
molecule keywords Bone morphogenetic protein 2
total genus 16
structure length 92
sequence length 92
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2006-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01064 Activin_recp Activin types I and II receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 2h64B00
1ZADA 5DU1A 3NH7A 2PJYC 1PLOA 3HH7A 3PLCA 2CCXA 5DZ5A 1IDLA 1CODA 2H8UA 4P7UA 1CRFA 3EVSC 1LXHA 4DO8A 4OM5A 1JE9A 2GOOC 3U74U 4AEAA 2JVEA 1CREA 1RL5A 2MJ0A 3BT1U 4ZQYA 1NYUA 2J8BA 2QJBC 4BDTB 1REWC 1F94A 1YWHA 2ERAA 1IDHA 1ABTA 1IKCA 2H64C 1TXAA 2PJYB 2UWRA 4RUDA 1KBAA 6EBXA 1COEA 5EBXA 1HOYA 2MFAA 1NTNA 2GOOB 1ONJA 1CHVS 5IMTD 2H7ZA 1F8UB 2H62D 4LFTA 5IMYC 1ERGA 2LCRA 3BT2U 2I9BE 3ERAA 2VLWA 1KBSA 1CVOA 1NEAA 2JQPA 1HAJA 1TGXA 1HC9A 2H64B 2L03A 4QTIU 1IK8A 1S4YA 3KFDE 1BXPA 3FEVA 2H5FA 2MJYA 1LX5B 4BIKB 1CDQA 2CRSA 1KS6A 2QC1A 1FASA 2UX2A 5DO6A 2N99A 3VTSA 1CDRA 3LAQU 4FAOC 1FRAA 3KFDI 4OM4A 4UY2C 1JBDA 2CRTA 2CDXA 1M9ZA 1RGJA 1IDIA 3NDSA 2H7ZB 1TFSA 2OFSA 1NTXA 2MUPA 1ERAA 2FD6U 1LXGA 2QJ9C 1CXOA 1QKDA 4EY8B 1HC9B 2X8BB 1G6MA 1CTXA 1KBTA 1DRSA 1FFJA 1KXIA 1TXBA 4HQPF 1I02A 1MR6A 1H0JA 4XJJA 2L5SA 1CDTA 1KTZB 4FAOE 2LA1A 2HLRA 1IQ9A 1BTEA 1NORA 1LJZA 2NBTA 1FSCA 1KFHA 1QM7A 1W6BA 2ABXA 1FF4A 2MUOA 2MHYA 3U73U 1UG4A 1KL8A 4IYEA 2K3GA 1KC4A 1QKEA 3EBXA 1XT3A 1LSIA 1FSSB 1B41B 2H62C 1KU6B 1NXBA 1CCQA 1VB0A 2BHIA 3QB4B 1MAHF 1IDGA 3NEQA 1CB9A 1CXNA 2CTXA 1HAAA 2QJAC 2MJ4A 1NYSA 2BTXA 1V6PA 1L4WA 2HLQA 1JGKA 1IJCA 1CDSA 1ES7B
chains in the Genus database with same CATH superfamily
1ZADA 5DU1A 3NH7A 2PJYC 1PLOA 3HH7A 3PLCA 2CCXA 5DZ5A 1IDLA 1CODA 2H8UA 4P7UA 1CRFA 3EVSC 1LXHA 4DO8A 4OM5A 1JE9A 2GOOC 3U74U 4AEAA 2JVEA 1CREA 1RL5A 2MJ0A 3BT1U 4ZQYA 1NYUA 2J8BA 2QJBC 4BDTB 1REWC 1F94A 1YWHA 2ERAA 1IDHA 1ABTA 1IKCA 2H64C 1TXAA 2PJYB 2UWRA 4RUDA 1KBAA 6EBXA 1COEA 5EBXA 1HOYA 2MFAA 1NTNA 2GOOB 1ONJA 1CHVS 5IMTD 2H7ZA 1F8UB 2H62D 4LFTA 5IMYC 1ERGA 2LCRA 3BT2U 2I9BE 3ERAA 2VLWA 1KBSA 1CVOA 1NEAA 2JQPA 1HAJA 1TGXA 1HC9A 2H64B 2L03A 4QTIU 1IK8A 1S4YA 3KFDE 1BXPA 3FEVA 2H5FA 2MJYA 1LX5B 4BIKB 1CDQA 2CRSA 1KS6A 2QC1A 1FASA 2UX2A 5DO6A 2N99A 3VTSA 1CDRA 3LAQU 4FAOC 1FRAA 4KSNA 3KFDI 4OM4A 4UY2C 1JBDA 2CRTA 2CDXA 1M9ZA 1RGJA 1IDIA 3NDSA 2H7ZB 1TFSA 2OFSA 1NTXA 2MUPA 1ERAA 2FD6U 1LXGA 2QJ9C 1CXOA 1QKDA 4EY8B 1HC9B 2X8BB 1G6MA 1CTXA 1KBTA 1DRSA 1FFJA 1KXIA 1TXBA 4HQPF 1I02A 1MR6A 1H0JA 4XJJA 2L5SA 1CDTA 1KTZB 4FAOE 2LA1A 2HLRA 1IQ9A 1BTEA 1NORA 1LJZA 2NBTA 1FSCA 1KFHA 1QM7A 1W6BA 2ABXA 1FF4A 2MUOA 2MHYA 3U73U 1UG4A 1KL8A 4IYEA 2K3GA 1KC4A 1QKEA 3EBXA 1XT3A 1LSIA 1FSSB 1B41B 2H62C 1KU6B 1NXBA 1CCQA 1VB0A 2BHIA 3QB4B 1MAHF 1IDGA 3NEQA 1CB9A 1CXNA 2CTXA 1HAAA 2QJAC 2MJ4A 1NYSA 2BTXA 1V6PA 1L4WA 2HLQA 1JGKA 1IJCA 1CDSA 1ES7B
chains in the Genus database with same CATH topology
1ZADA 5DU1A 3NH7A 2PJYC 1PLOA 3HH7A 3PLCA 2CCXA 5DZ5A 1IDLA 1CODA 2H8UA 4P7UA 1CRFA 3EVSC 1LXHA 4DO8A 4OM5A 1JE9A 2GOOC 3U74U 4AEAA 2JVEA 1CREA 1RL5A 2MJ0A 3BT1U 4ZQYA 1NYUA 2J8BA 2QJBC 4BDTB 1REWC 1F94A 1YWHA 2ERAA 1IDHA 1ABTA 1IKCA 2H64C 1TXAA 2PJYB 2UWRA 4RUDA 1KBAA 6EBXA 1COEA 5EBXA 1HOYA 2MFAA 1NTNA 2GOOB 1ONJA 1CHVS 5IMTD 2H7ZA 1F8UB 2H62D 4LFTA 5IMYC 1ERGA 2LCRA 3BT2U 2I9BE 3ERAA 2VLWA 1KBSA 1CVOA 1NEAA 2JQPA 1HAJA 1TGXA 1HC9A 2H64B 2L03A 4QTIU 1IK8A 1S4YA 3KFDE 1BXPA 3FEVA 2H5FA 2MJYA 1LX5B 4BIKB 1CDQA 2CRSA 1KS6A 2QC1A 1FASA 2UX2A 5DO6A 2N99A 3VTSA 1CDRA 3LAQU 4FAOC 1FRAA 4KSNA 3KFDI 4OM4A 4UY2C 1JBDA 2CRTA 2CDXA 1M9ZA 1RGJA 1IDIA 3NDSA 2H7ZB 1TFSA 2OFSA 1NTXA 2MUPA 1ERAA 2FD6U 1LXGA 2QJ9C 1CXOA 1QKDA 4EY8B 1HC9B 2X8BB 1G6MA 1CTXA 1KBTA 1DRSA 1FFJA 1KXIA 1TXBA 4HQPF 1I02A 1MR6A 1H0JA 4XJJA 2L5SA 1CDTA 1KTZB 4FAOE 2LA1A 2HLRA 1IQ9A 1BTEA 1NORA 1LJZA 2NBTA 1FSCA 1KFHA 1QM7A 1W6BA 2ABXA 1FF4A 2MUOA 2MHYA 3U73U 1UG4A 1KL8A 4IYEA 2K3GA 1KC4A 1QKEA 3EBXA 1XT3A 1LSIA 1FSSB 1B41B 2H62C 1KU6B 1NXBA 1CCQA 1VB0A 2BHIA 3QB4B 1MAHF 1IDGA 3NEQA 1CB9A 1CXNA 2CTXA 1HAAA 2QJAC 2MJ4A 1NYSA 2BTXA 1V6PA 1L4WA 2HLQA 1JGKA 1IJCA 1CDSA 1ES7B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZAD A;  5DU1 A;  3NH7 A;  2PJY C;  1PLO A;  3HH7 A;  3PLC A;  2CCX A;  5DZ5 A;  1IDL A;  1COD A;  2H8U A;  4P7U A;  1CRF A;  3EVS C;  1LXH A;  4DO8 A;  4OM5 A;  1JE9 A;  2GOO C;  3U74 U;  4AEA A;  2JVE A;  1CRE A;  1RL5 A;  2MJ0 A;  3BT1 U;  4ZQY A;  1NYU A;  2J8B A;  2QJB C;  4BDT B;  1REW C;  1F94 A;  1YWH A;  2ERA A;  1IDH A;  1ABT A;  1IKC A;  2H64 C;  1TXA A;  2PJY B;  2UWR A;  4RUD A;  1KBA A;  6EBX A;  1COE A;  5EBX A;  1HOY A;  2MFA A;  1NTN A;  2GOO B;  1ONJ A;  1CHV S;  5IMT D;  2H7Z A;  1F8U B;  2H62 D;  4LFT A;  5IMY C;  1ERG A;  2LCR A;  3BT2 U;  2I9B E;  3ERA A;  2VLW A;  1KBS A;  1CVO A;  1NEA A;  2JQP A;  1HAJ A;  1TGX A;  1HC9 A;  2H64 B;  2L03 A;  4QTI U;  1IK8 A;  1S4Y A;  3KFD E;  1BXP A;  3FEV A;  2H5F A;  2MJY A;  1LX5 B;  4BIK B;  1CDQ A;  2CRS A;  1KS6 A;  2QC1 A;  1FAS A;  2UX2 A;  5DO6 A;  2N99 A;  3VTS A;  1CDR A;  3LAQ U;  4FAO C;  1FRA A;  3KFD I;  4OM4 A;  4UY2 C;  1JBD A;  2CRT A;  2CDX A;  1M9Z A;  1RGJ A;  1IDI A;  3NDS A;  2H7Z B;  1TFS A;  2OFS A;  1NTX A;  2MUP A;  1ERA A;  2FD6 U;  1LXG A;  2QJ9 C;  1CXO A;  1QKD A;  4EY8 B;  1HC9 B;  2X8B B;  1G6M A;  1CTX A;  1KBT A;  1DRS A;  1FFJ A;  1KXI A;  1TXB A;  4HQP F;  1I02 A;  1MR6 A;  1H0J A;  4XJJ A;  2L5S A;  1CDT A;  1KTZ B;  4FAO E;  2LA1 A;  2HLR A;  1IQ9 A;  1BTE A;  1NOR A;  1LJZ A;  2NBT A;  1FSC A;  1KFH A;  1QM7 A;  1W6B A;  2ABX A;  1FF4 A;  2MUO A;  2MHY A;  3U73 U;  1UG4 A;  1KL8 A;  4IYE A;  2K3G A;  1KC4 A;  1QKE A;  3EBX A;  1XT3 A;  1LSI A;  1FSS B;  1B41 B;  2H62 C;  1KU6 B;  1NXB A;  1CCQ A;  1VB0 A;  2BHI A;  3QB4 B;  1MAH F;  1IDG A;  3NEQ A;  1CB9 A;  1CXN A;  2CTX A;  1HAA A;  2QJA C;  2MJ4 A;  1NYS A;  2BTX A;  1V6P A;  1L4W A;  2HLQ A;  1JGK A;  1IJC A;  1CDS A;  1ES7 B; 
#chains in the Genus database with same CATH topology
 1ZAD A;  5DU1 A;  3NH7 A;  2PJY C;  1PLO A;  3HH7 A;  3PLC A;  2CCX A;  5DZ5 A;  1IDL A;  1COD A;  2H8U A;  4P7U A;  1CRF A;  3EVS C;  1LXH A;  4DO8 A;  4OM5 A;  1JE9 A;  2GOO C;  3U74 U;  4AEA A;  2JVE A;  1CRE A;  1RL5 A;  2MJ0 A;  3BT1 U;  4ZQY A;  1NYU A;  2J8B A;  2QJB C;  4BDT B;  1REW C;  1F94 A;  1YWH A;  2ERA A;  1IDH A;  1ABT A;  1IKC A;  2H64 C;  1TXA A;  2PJY B;  2UWR A;  4RUD A;  1KBA A;  6EBX A;  1COE A;  5EBX A;  1HOY A;  2MFA A;  1NTN A;  2GOO B;  1ONJ A;  1CHV S;  5IMT D;  2H7Z A;  1F8U B;  2H62 D;  4LFT A;  5IMY C;  1ERG A;  2LCR A;  3BT2 U;  2I9B E;  3ERA A;  2VLW A;  1KBS A;  1CVO A;  1NEA A;  2JQP A;  1HAJ A;  1TGX A;  1HC9 A;  2H64 B;  2L03 A;  4QTI U;  1IK8 A;  1S4Y A;  3KFD E;  1BXP A;  3FEV A;  2H5F A;  2MJY A;  1LX5 B;  4BIK B;  1CDQ A;  2CRS A;  1KS6 A;  2QC1 A;  1FAS A;  2UX2 A;  5DO6 A;  2N99 A;  3VTS A;  1CDR A;  3LAQ U;  4FAO C;  1FRA A;  4KSN A;  3KFD I;  4OM4 A;  4UY2 C;  1JBD A;  2CRT A;  2CDX A;  1M9Z A;  1RGJ A;  1IDI A;  3NDS A;  2H7Z B;  1TFS A;  2OFS A;  1NTX A;  2MUP A;  1ERA A;  2FD6 U;  1LXG A;  2QJ9 C;  1CXO A;  1QKD A;  4EY8 B;  1HC9 B;  2X8B B;  1G6M A;  1CTX A;  1KBT A;  1DRS A;  1FFJ A;  1KXI A;  1TXB A;  4HQP F;  1I02 A;  1MR6 A;  1H0J A;  4XJJ A;  2L5S A;  1CDT A;  1KTZ B;  4FAO E;  2LA1 A;  2HLR A;  1IQ9 A;  1BTE A;  1NOR A;  1LJZ A;  2NBT A;  1FSC A;  1KFH A;  1QM7 A;  1W6B A;  2ABX A;  1FF4 A;  2MUO A;  2MHY A;  3U73 U;  1UG4 A;  1KL8 A;  4IYE A;  2K3G A;  1KC4 A;  1QKE A;  3EBX A;  1XT3 A;  1LSI A;  1FSS B;  1B41 B;  2H62 C;  1KU6 B;  1NXB A;  1CCQ A;  1VB0 A;  2BHI A;  3QB4 B;  1MAH F;  1IDG A;  3NEQ A;  1CB9 A;  1CXN A;  2CTX A;  1HAA A;  2QJA C;  2MJ4 A;  1NYS A;  2BTX A;  1V6P A;  1L4W A;  2HLQ A;  1JGK A;  1IJC A;  1CDS A;  1ES7 B; 
#chains in the Genus database with same CATH homology
 1ZAD A;  5DU1 A;  3NH7 A;  2PJY C;  1PLO A;  3HH7 A;  3PLC A;  2CCX A;  5DZ5 A;  1IDL A;  1COD A;  2H8U A;  4P7U A;  1CRF A;  3EVS C;  1LXH A;  4DO8 A;  4OM5 A;  1JE9 A;  2GOO C;  3U74 U;  4AEA A;  2JVE A;  1CRE A;  1RL5 A;  2MJ0 A;  3BT1 U;  4ZQY A;  1NYU A;  2J8B A;  2QJB C;  4BDT B;  1REW C;  1F94 A;  1YWH A;  2ERA A;  1IDH A;  1ABT A;  1IKC A;  2H64 C;  1TXA A;  2PJY B;  2UWR A;  4RUD A;  1KBA A;  6EBX A;  1COE A;  5EBX A;  1HOY A;  2MFA A;  1NTN A;  2GOO B;  1ONJ A;  1CHV S;  5IMT D;  2H7Z A;  1F8U B;  2H62 D;  4LFT A;  5IMY C;  1ERG A;  2LCR A;  3BT2 U;  2I9B E;  3ERA A;  2VLW A;  1KBS A;  1CVO A;  1NEA A;  2JQP A;  1HAJ A;  1TGX A;  1HC9 A;  2H64 B;  2L03 A;  4QTI U;  1IK8 A;  1S4Y A;  3KFD E;  1BXP A;  3FEV A;  2H5F A;  2MJY A;  1LX5 B;  4BIK B;  1CDQ A;  2CRS A;  1KS6 A;  2QC1 A;  1FAS A;  2UX2 A;  5DO6 A;  2N99 A;  3VTS A;  1CDR A;  3LAQ U;  4FAO C;  1FRA A;  4KSN A;  3KFD I;  4OM4 A;  4UY2 C;  1JBD A;  2CRT A;  2CDX A;  1M9Z A;  1RGJ A;  1IDI A;  3NDS A;  2H7Z B;  1TFS A;  2OFS A;  1NTX A;  2MUP A;  1ERA A;  2FD6 U;  1LXG A;  2QJ9 C;  1CXO A;  1QKD A;  4EY8 B;  1HC9 B;  2X8B B;  1G6M A;  1CTX A;  1KBT A;  1DRS A;  1FFJ A;  1KXI A;  1TXB A;  4HQP F;  1I02 A;  1MR6 A;  1H0J A;  4XJJ A;  2L5S A;  1CDT A;  1KTZ B;  4FAO E;  2LA1 A;  2HLR A;  1IQ9 A;  1BTE A;  1NOR A;  1LJZ A;  2NBT A;  1FSC A;  1KFH A;  1QM7 A;  1W6B A;  2ABX A;  1FF4 A;  2MUO A;  2MHY A;  3U73 U;  1UG4 A;  1KL8 A;  4IYE A;  2K3G A;  1KC4 A;  1QKE A;  3EBX A;  1XT3 A;  1LSI A;  1FSS B;  1B41 B;  2H62 C;  1KU6 B;  1NXB A;  1CCQ A;  1VB0 A;  2BHI A;  3QB4 B;  1MAH F;  1IDG A;  3NEQ A;  1CB9 A;  1CXN A;  2CTX A;  1HAA A;  2QJA C;  2MJ4 A;  1NYS A;  2BTX A;  1V6P A;  1L4W A;  2HLQ A;  1JGK A;  1IJC A;  1CDS A;  1ES7 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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