3QB4B

Crystal structure of a tgf-beta ligand-receptor complex
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
88
structure length
88
Chain Sequence
DTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Cytokine/transferase receptor
source organism Homo sapiens
publication title GDF-5 can act as a context-dependent BMP-2 antagonist.
pubmed doi rcsb
molecule keywords Growth/differentiation factor 5
total genus 12
structure length 88
sequence length 88
chains with identical sequence D
ec nomenclature ec 2.7.11.30: Receptor protein serine/threonine kinase.
pdb deposition date 2011-01-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01064 Activin_recp Activin types I and II receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 3qb4B00
1QM7A 2H62C 1CRFA 1HAJA 3NH7A 2H5FA 1FFJA 1CODA 1CXOA 2BTXA 1I02A 2NBTA 4UY2C 3ERAA 1F94A 2MUPA 4OM4A 2ABXA 1KL8A 1REWC 1LXGA 2HLQA 3VTSA 2QJ9C 1CTXA 1JBDA 2CRTA 2UWRA 3LAQU 1FSCA 1TFSA 1CDQA 1TGXA 1MR6A 3EBXA 1NXBA 2H64C 1CVOA 3KFDE 3NDSA 3NEQA 1MAHF 2JVEA 1NTXA 2HLRA 2MHYA 1CXNA 2PJYB 2CCXA 2BHIA 2H7ZB 1KBTA 1KS6A 1CHVS 1IDGA 3BT2U 1ONJA 1ERGA 1HC9A 4OM5A 1CDRA 1JGKA 2CRSA 1LXHA 5EBXA 1IJCA 2CTXA 5DO6A 1HOYA 1VB0A 4BIKB 1S4YA 1IK8A 4FAOC 2GOOC 1NYSA 3HH7A 4P7UA 1KBSA 5IMYC 5IMTD 1ERAA 1B41B 2JQPA 1CDTA 1V6PA 2X8BB 3QB4B 2MJ4A 2QC1A 1H0JA 1QKDA 1W6BA 1ABTA 2N99A 1CCQA 2MJ0A 2ERAA 3KFDI 2K3GA 2L5SA 1M9ZA 3EVSC 2H8UA 1CREA 1F8UB 1NTNA 2LA1A 2I9BE 2OFSA 1KBAA 4RUDA 1FF4A 1RL5A 2QJBC 4QTIU 1PLOA 2UX2A 6EBXA 4IYEA 2LCRA 1FSSB 1LSIA 1ZADA 1RGJA 4XJJA 3PLCA 1DRSA 1QKEA 2L03A 4HQPF 1XT3A 1HAAA 1HC9B 1NORA 4AEAA 4EY8B 4BDTB 2CDXA 2PJYC 1CB9A 1COEA 2MFAA 2H64B 1JE9A 5DU1A 5DZ5A 1KFHA 2QJAC 1KXIA 1BXPA 2FD6U 1LX5B 1KU6B 4ZQYA 1L4WA 2MJYA 1G6MA 1NEAA 2H62D 1IQ9A 4LFTA 1KTZB 1KC4A 1ES7B 1IDIA 1FRAA 1TXBA 1NYUA 2H7ZA 1CDSA 1LJZA 2MUOA 1IDLA 2VLWA 4FAOE 1UG4A 3BT1U 2GOOB 3U74U 1YWHA 4DO8A 1IKCA 1IDHA 2J8BA 3FEVA 1FASA 3U73U 1BTEA 1TXAA
chains in the Genus database with same CATH superfamily
1QM7A 2H62C 1CRFA 1HAJA 3NH7A 2H5FA 1FFJA 1CODA 1CXOA 2BTXA 1I02A 2NBTA 4UY2C 3ERAA 1F94A 2MUPA 4OM4A 2ABXA 1KL8A 1REWC 1LXGA 2HLQA 3VTSA 2QJ9C 1CTXA 1JBDA 2CRTA 2UWRA 3LAQU 1FSCA 1TFSA 1CDQA 1TGXA 1MR6A 3EBXA 1NXBA 2H64C 1CVOA 3KFDE 3NDSA 3NEQA 1MAHF 2JVEA 1NTXA 2HLRA 2MHYA 1CXNA 2PJYB 2CCXA 2BHIA 2H7ZB 1KBTA 1KS6A 1CHVS 1IDGA 3BT2U 1ONJA 1ERGA 1HC9A 4OM5A 1CDRA 1JGKA 2CRSA 1LXHA 5EBXA 1IJCA 2CTXA 5DO6A 1HOYA 1VB0A 4BIKB 1S4YA 1IK8A 4FAOC 2GOOC 1NYSA 3HH7A 4P7UA 1KBSA 5IMYC 5IMTD 1ERAA 1B41B 2JQPA 1CDTA 1V6PA 2X8BB 3QB4B 2MJ4A 2QC1A 1H0JA 1QKDA 1W6BA 1ABTA 2N99A 1CCQA 2MJ0A 2ERAA 3KFDI 2K3GA 2L5SA 1M9ZA 3EVSC 2H8UA 1CREA 1F8UB 1NTNA 2LA1A 2I9BE 2OFSA 1KBAA 4RUDA 1FF4A 1RL5A 2QJBC 4QTIU 1PLOA 2UX2A 6EBXA 4IYEA 2LCRA 1FSSB 1LSIA 1ZADA 1RGJA 4KSNA 3PLCA 4XJJA 1QKEA 2L03A 4HQPF 1XT3A 1HAAA 1HC9B 1NORA 4AEAA 4EY8B 4BDTB 2CDXA 2PJYC 1CB9A 1COEA 2MFAA 2H64B 1JE9A 5DU1A 5DZ5A 1KFHA 2QJAC 1KXIA 1BXPA 2FD6U 1LX5B 1KU6B 4ZQYA 1L4WA 2MJYA 1G6MA 1NEAA 2H62D 1DRSA 1IQ9A 4LFTA 1KTZB 1KC4A 1ES7B 1IDIA 1FRAA 1TXBA 1NYUA 2H7ZA 1CDSA 1LJZA 2MUOA 1IDLA 2VLWA 4FAOE 1UG4A 3BT1U 2GOOB 3U74U 1YWHA 4DO8A 1IKCA 1IDHA 2J8BA 3FEVA 1FASA 3U73U 1BTEA 1TXAA
chains in the Genus database with same CATH topology
1QM7A 2H62C 1CRFA 1HAJA 3NH7A 2H5FA 1FFJA 1CODA 1CXOA 2BTXA 1I02A 2NBTA 4UY2C 3ERAA 1F94A 2MUPA 4OM4A 2ABXA 1KL8A 1REWC 1LXGA 2HLQA 3VTSA 2QJ9C 1CTXA 1JBDA 2CRTA 2UWRA 3LAQU 1FSCA 1TFSA 1CDQA 1TGXA 1MR6A 3EBXA 1NXBA 2H64C 1CVOA 3KFDE 3NDSA 3NEQA 1MAHF 2JVEA 1NTXA 2HLRA 2MHYA 1CXNA 2PJYB 2CCXA 2BHIA 2H7ZB 1KBTA 1KS6A 1CHVS 1IDGA 3BT2U 1ONJA 1ERGA 1HC9A 4OM5A 1CDRA 1JGKA 2CRSA 1LXHA 5EBXA 1IJCA 2CTXA 5DO6A 1HOYA 1VB0A 4BIKB 1S4YA 1IK8A 4FAOC 2GOOC 1NYSA 3HH7A 4P7UA 1KBSA 5IMYC 5IMTD 1ERAA 1B41B 2JQPA 1CDTA 1V6PA 2X8BB 3QB4B 2MJ4A 2QC1A 1H0JA 1QKDA 1W6BA 1ABTA 2N99A 1CCQA 2MJ0A 2ERAA 3KFDI 2K3GA 2L5SA 1M9ZA 3EVSC 2H8UA 1CREA 1F8UB 1NTNA 2LA1A 2I9BE 2OFSA 1KBAA 4RUDA 1FF4A 1RL5A 2QJBC 4QTIU 1PLOA 2UX2A 6EBXA 4IYEA 2LCRA 1FSSB 1LSIA 1ZADA 1RGJA 4KSNA 3PLCA 4XJJA 1QKEA 2L03A 4HQPF 1XT3A 1HAAA 1HC9B 1NORA 4AEAA 4EY8B 4BDTB 2CDXA 2PJYC 1CB9A 1COEA 2MFAA 2H64B 1JE9A 5DU1A 5DZ5A 1KFHA 2QJAC 1KXIA 1BXPA 2FD6U 1LX5B 1KU6B 4ZQYA 1L4WA 2MJYA 1G6MA 1NEAA 2H62D 1DRSA 1IQ9A 4LFTA 1KTZB 1KC4A 1ES7B 1IDIA 1FRAA 1TXBA 1NYUA 2H7ZA 1CDSA 1LJZA 2MUOA 1IDLA 2VLWA 4FAOE 1UG4A 3BT1U 2GOOB 3U74U 1YWHA 4DO8A 1IKCA 1IDHA 2J8BA 3FEVA 1FASA 3U73U 1BTEA 1TXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QM7 A;  2H62 C;  1CRF A;  1HAJ A;  3NH7 A;  2H5F A;  1FFJ A;  1COD A;  1CXO A;  2BTX A;  1I02 A;  2NBT A;  4UY2 C;  3ERA A;  1F94 A;  2MUP A;  4OM4 A;  2ABX A;  1KL8 A;  1REW C;  1LXG A;  2HLQ A;  3VTS A;  2QJ9 C;  1CTX A;  1JBD A;  2CRT A;  2UWR A;  3LAQ U;  1FSC A;  1TFS A;  1CDQ A;  1TGX A;  1MR6 A;  3EBX A;  1NXB A;  2H64 C;  1CVO A;  3KFD E;  3NDS A;  3NEQ A;  1MAH F;  2JVE A;  1NTX A;  2HLR A;  2MHY A;  1CXN A;  2PJY B;  2CCX A;  2BHI A;  2H7Z B;  1KBT A;  1KS6 A;  1CHV S;  1IDG A;  3BT2 U;  1ONJ A;  1ERG A;  1HC9 A;  4OM5 A;  1CDR A;  1JGK A;  2CRS A;  1LXH A;  5EBX A;  1IJC A;  2CTX A;  5DO6 A;  1HOY A;  1VB0 A;  4BIK B;  1S4Y A;  1IK8 A;  4FAO C;  2GOO C;  1NYS A;  3HH7 A;  4P7U A;  1KBS A;  5IMY C;  5IMT D;  1ERA A;  1B41 B;  2JQP A;  1CDT A;  1V6P A;  2X8B B;  3QB4 B;  2MJ4 A;  2QC1 A;  1H0J A;  1QKD A;  1W6B A;  1ABT A;  2N99 A;  1CCQ A;  2MJ0 A;  2ERA A;  3KFD I;  2K3G A;  2L5S A;  1M9Z A;  3EVS C;  2H8U A;  1CRE A;  1F8U B;  1NTN A;  2LA1 A;  2I9B E;  2OFS A;  1KBA A;  4RUD A;  1FF4 A;  1RL5 A;  2QJB C;  4QTI U;  1PLO A;  2UX2 A;  6EBX A;  4IYE A;  2LCR A;  1FSS B;  1LSI A;  1ZAD A;  1RGJ A;  4XJJ A;  3PLC A;  1DRS A;  1QKE A;  2L03 A;  4HQP F;  1XT3 A;  1HAA A;  1HC9 B;  1NOR A;  4AEA A;  4EY8 B;  4BDT B;  2CDX A;  2PJY C;  1CB9 A;  1COE A;  2MFA A;  2H64 B;  1JE9 A;  5DU1 A;  5DZ5 A;  1KFH A;  2QJA C;  1KXI A;  1BXP A;  2FD6 U;  1LX5 B;  1KU6 B;  4ZQY A;  1L4W A;  2MJY A;  1G6M A;  1NEA A;  2H62 D;  1IQ9 A;  4LFT A;  1KTZ B;  1KC4 A;  1ES7 B;  1IDI A;  1FRA A;  1TXB A;  1NYU A;  2H7Z A;  1CDS A;  1LJZ A;  2MUO A;  1IDL A;  2VLW A;  4FAO E;  1UG4 A;  3BT1 U;  2GOO B;  3U74 U;  1YWH A;  4DO8 A;  1IKC A;  1IDH A;  2J8B A;  3FEV A;  1FAS A;  3U73 U;  1BTE A;  1TXA A; 
#chains in the Genus database with same CATH topology
 1QM7 A;  2H62 C;  1CRF A;  1HAJ A;  3NH7 A;  2H5F A;  1FFJ A;  1COD A;  1CXO A;  2BTX A;  1I02 A;  2NBT A;  4UY2 C;  3ERA A;  1F94 A;  2MUP A;  4OM4 A;  2ABX A;  1KL8 A;  1REW C;  1LXG A;  2HLQ A;  3VTS A;  2QJ9 C;  1CTX A;  1JBD A;  2CRT A;  2UWR A;  3LAQ U;  1FSC A;  1TFS A;  1CDQ A;  1TGX A;  1MR6 A;  3EBX A;  1NXB A;  2H64 C;  1CVO A;  3KFD E;  3NDS A;  3NEQ A;  1MAH F;  2JVE A;  1NTX A;  2HLR A;  2MHY A;  1CXN A;  2PJY B;  2CCX A;  2BHI A;  2H7Z B;  1KBT A;  1KS6 A;  1CHV S;  1IDG A;  3BT2 U;  1ONJ A;  1ERG A;  1HC9 A;  4OM5 A;  1CDR A;  1JGK A;  2CRS A;  1LXH A;  5EBX A;  1IJC A;  2CTX A;  5DO6 A;  1HOY A;  1VB0 A;  4BIK B;  1S4Y A;  1IK8 A;  4FAO C;  2GOO C;  1NYS A;  3HH7 A;  4P7U A;  1KBS A;  5IMY C;  5IMT D;  1ERA A;  1B41 B;  2JQP A;  1CDT A;  1V6P A;  2X8B B;  3QB4 B;  2MJ4 A;  2QC1 A;  1H0J A;  1QKD A;  1W6B A;  1ABT A;  2N99 A;  1CCQ A;  2MJ0 A;  2ERA A;  3KFD I;  2K3G A;  2L5S A;  1M9Z A;  3EVS C;  2H8U A;  1CRE A;  1F8U B;  1NTN A;  2LA1 A;  2I9B E;  2OFS A;  1KBA A;  4RUD A;  1FF4 A;  1RL5 A;  2QJB C;  4QTI U;  1PLO A;  2UX2 A;  6EBX A;  4IYE A;  2LCR A;  1FSS B;  1LSI A;  1ZAD A;  1RGJ A;  4KSN A;  3PLC A;  4XJJ A;  1QKE A;  2L03 A;  4HQP F;  1XT3 A;  1HAA A;  1HC9 B;  1NOR A;  4AEA A;  4EY8 B;  4BDT B;  2CDX A;  2PJY C;  1CB9 A;  1COE A;  2MFA A;  2H64 B;  1JE9 A;  5DU1 A;  5DZ5 A;  1KFH A;  2QJA C;  1KXI A;  1BXP A;  2FD6 U;  1LX5 B;  1KU6 B;  4ZQY A;  1L4W A;  2MJY A;  1G6M A;  1NEA A;  2H62 D;  1DRS A;  1IQ9 A;  4LFT A;  1KTZ B;  1KC4 A;  1ES7 B;  1IDI A;  1FRA A;  1TXB A;  1NYU A;  2H7Z A;  1CDS A;  1LJZ A;  2MUO A;  1IDL A;  2VLW A;  4FAO E;  1UG4 A;  3BT1 U;  2GOO B;  3U74 U;  1YWH A;  4DO8 A;  1IKC A;  1IDH A;  2J8B A;  3FEV A;  1FAS A;  3U73 U;  1BTE A;  1TXA A; 
#chains in the Genus database with same CATH homology
 1QM7 A;  2H62 C;  1CRF A;  1HAJ A;  3NH7 A;  2H5F A;  1FFJ A;  1COD A;  1CXO A;  2BTX A;  1I02 A;  2NBT A;  4UY2 C;  3ERA A;  1F94 A;  2MUP A;  4OM4 A;  2ABX A;  1KL8 A;  1REW C;  1LXG A;  2HLQ A;  3VTS A;  2QJ9 C;  1CTX A;  1JBD A;  2CRT A;  2UWR A;  3LAQ U;  1FSC A;  1TFS A;  1CDQ A;  1TGX A;  1MR6 A;  3EBX A;  1NXB A;  2H64 C;  1CVO A;  3KFD E;  3NDS A;  3NEQ A;  1MAH F;  2JVE A;  1NTX A;  2HLR A;  2MHY A;  1CXN A;  2PJY B;  2CCX A;  2BHI A;  2H7Z B;  1KBT A;  1KS6 A;  1CHV S;  1IDG A;  3BT2 U;  1ONJ A;  1ERG A;  1HC9 A;  4OM5 A;  1CDR A;  1JGK A;  2CRS A;  1LXH A;  5EBX A;  1IJC A;  2CTX A;  5DO6 A;  1HOY A;  1VB0 A;  4BIK B;  1S4Y A;  1IK8 A;  4FAO C;  2GOO C;  1NYS A;  3HH7 A;  4P7U A;  1KBS A;  5IMY C;  5IMT D;  1ERA A;  1B41 B;  2JQP A;  1CDT A;  1V6P A;  2X8B B;  3QB4 B;  2MJ4 A;  2QC1 A;  1H0J A;  1QKD A;  1W6B A;  1ABT A;  2N99 A;  1CCQ A;  2MJ0 A;  2ERA A;  3KFD I;  2K3G A;  2L5S A;  1M9Z A;  3EVS C;  2H8U A;  1CRE A;  1F8U B;  1NTN A;  2LA1 A;  2I9B E;  2OFS A;  1KBA A;  4RUD A;  1FF4 A;  1RL5 A;  2QJB C;  4QTI U;  1PLO A;  2UX2 A;  6EBX A;  4IYE A;  2LCR A;  1FSS B;  1LSI A;  1ZAD A;  1RGJ A;  4KSN A;  3PLC A;  4XJJ A;  1QKE A;  2L03 A;  4HQP F;  1XT3 A;  1HAA A;  1HC9 B;  1NOR A;  4AEA A;  4EY8 B;  4BDT B;  2CDX A;  2PJY C;  1CB9 A;  1COE A;  2MFA A;  2H64 B;  1JE9 A;  5DU1 A;  5DZ5 A;  1KFH A;  2QJA C;  1KXI A;  1BXP A;  2FD6 U;  1LX5 B;  1KU6 B;  4ZQY A;  1L4W A;  2MJY A;  1G6M A;  1NEA A;  2H62 D;  1DRS A;  1IQ9 A;  4LFT A;  1KTZ B;  1KC4 A;  1ES7 B;  1IDI A;  1FRA A;  1TXB A;  1NYU A;  2H7Z A;  1CDS A;  1LJZ A;  2MUO A;  1IDL A;  2VLW A;  4FAO E;  1UG4 A;  3BT1 U;  2GOO B;  3U74 U;  1YWH A;  4DO8 A;  1IKC A;  1IDH A;  2J8B A;  3FEV A;  1FAS A;  3U73 U;  1BTE A;  1TXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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